parallel randomized trial
NCT02160990
Effect of Exenatide in Obese Patients With Accelerated Gastric Emptying
Design
Conduct and analysis
Arms
| Arm | Treatment | Background | Randomized | Analyzed | Completed treatment |
|---|---|---|---|---|---|
| A1 | Placebo Placebo twice daily | lifestyle: none | 10 | 10 | |
| A2 | Exenatide 5 ug subcutaneous twice daily Exenatide 5 ug twice daily | lifestyle: none | 10 | 10 |
Baseline characteristics
As printed in the trial reports or registry, per arm or for the whole trial.
| Characteristic | Statistic | Placebo A1 | Exenatide 5 ug subcutaneous twice daily A2 |
|---|---|---|---|
| age | median (years) | 42.5 | 34 |
| age | q1 (years) | 25.3 | 33 |
| age | q3 (years) | 49.5 | 46.8 |
| bmi | median (kg/m2) | 34.2 | 33.5 |
| bmi | q1 (kg/m2) | 31.7 | 32.9 |
| bmi | q3 (kg/m2) | 38.5 | 36.7 |
| female | percent | 70 | 60 |
| hispanic | percent | 10 | 10 |
| waist | median (cm) | 108.5 | 107.7 |
| waist | q1 (cm) | 105 | 100 |
| waist | q3 (cm) | 118 | 121 |
| weight | median (kg) | 103.4 | 98.1 |
| weight | q1 (kg) | 87.6 | 89.4 |
| weight | q3 (kg) | 111.9 | 109.7 |
| white | percent | 90 | 90 |
Analyses this trial contributes to
- Serious adverse eventsOverweight or obesity without diabetes (adults); longest follow-up; network meta-analysis
- Serious adverse eventsOverweight or obesity without diabetes (adults); longest follow-up; network meta-analysis
- Discontinuation due to adverse eventsOverweight or obesity without diabetes (adults); longest follow-up; network meta-analysis
- Discontinuation due to adverse eventsOverweight or obesity without diabetes (adults); longest follow-up; network meta-analysis
- NauseaOverweight or obesity without diabetes (adults); longest follow-up; network meta-analysis
- NauseaOverweight or obesity without diabetes (adults); longest follow-up; network meta-analysis
- VomitingOverweight or obesity without diabetes (adults); longest follow-up; network meta-analysis
- VomitingOverweight or obesity without diabetes (adults); longest follow-up; network meta-analysis
- DiarrheaOverweight or obesity without diabetes (adults); longest follow-up; network meta-analysis
- DiarrheaOverweight or obesity without diabetes (adults); longest follow-up; network meta-analysis
- ConstipationOverweight or obesity without diabetes (adults); longest follow-up; network meta-analysis
- ConstipationOverweight or obesity without diabetes (adults); longest follow-up; network meta-analysis
Results
14 adjudicated result lines, grouped by outcome. Open an outcome to see its values.
All cause mortality (2 lines; O20)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 0 / 10 | not stated; randomized; R0020690:Results | ||||
| A2 | events | 0 / 10 | not stated; randomized; R0020690:Results |
Serious adverse events (2 lines; O25)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 0 / 10 | not stated; randomized; R0020690:Results | ||||
| A2 | events | 0 / 10 | not stated; randomized; R0020690:Results |
Discontinuation due to adverse events (2 lines; O26)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 0 / 10 | not stated; randomized; R0020690:Results | ||||
| A2 | events | 0 / 10 | not stated; randomized; R0020690:Results |
Nausea (2 lines; O27A)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 0 / 10 | not stated; randomized; R0020690:Results | ||||
| A2 | events | 0 / 10 | not stated; randomized; R0020690:Results |
Vomiting (2 lines; O27B)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 0 / 10 | not stated; randomized; R0020690:Results | ||||
| A2 | events | 0 / 10 | not stated; randomized; R0020690:Results |
Diarrhea (2 lines; O27C)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 0 / 10 | not stated; randomized; R0020690:Results | ||||
| A2 | events | 0 / 10 | not stated; randomized; R0020690:Results |
Constipation (2 lines; O27D)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 0 / 10 | not stated; randomized; R0020690:Results | ||||
| A2 | events | 0 / 10 | not stated; randomized; R0020690:Results |