Discontinuation due to adverse events
Overweight or obesity without diabetes (adults)
In plain language
Across 24 trials with 7,544 participants, 0 of 58 treatments had a clearly better result than placebo on discontinuation due to adverse events, 13 a clearly worse one, and for 45 the evidence could not tell them apart from placebo. The most favorable estimate was for HRS-7535 120 mg tablet once daily: hazard ratio (from event counts) 0.25 (95% credible interval 0.00 to 6.22).
Lower values favor the treatment. "Clearly" means the 95% credible interval excludes no difference. These are averages across trials; they do not say how any one person will respond. Not medical advice.
Network of trials
Effects compared with Placebo
| Treatment | Bayesian HR (95% CrI) | 95% prediction interval | Frequentist HR (95% CI) | Verdict |
|---|---|---|---|---|
| HRS-7535 120 mg tablet once daily HRS7535_PO_120MG_QD | 0.25 (0.00 to 6.22) | 0.00 to 6.21 | Unclear | |
| Standard care or no added treatment STANDARD_CARE | 0.37 (0.02 to 7.15) | 0.02 to 7.32 | Unclear | |
| Mazdutide 3 mg subcutaneous once weekly MAZD_SC_3MG_QW | 0.41 (0.01 to 16.58) | 0.00 to 17.23 | Unclear | |
| Mazdutide 6 mg subcutaneous once weekly MAZD_SC_6MG_QW | 0.42 (0.01 to 16.02) | 0.01 to 17.30 | Unclear | |
| Tirzepatide maximum tolerated dose injection once weekly TIRZ_SC_MTD_5-10-15_QW | 0.49 (0.02 to 9.38) | 0.02 to 9.67 | Unclear | |
| Exenatide 5 ug subcutaneous twice daily EXEN_SC_5UG_BID | 0.57 (0.01 to 43.47) | 0.01 to 43.35 | Unclear | |
| Ct388 sc 12mg qw CT388_SC_12MG_QW | 0.61 (0.01 to 42.01) | 0.01 to 42.30 | Unclear | |
| Semaglutide 1.0 mg subcutaneous once weekly SEMA_SC_1p0MG_QW | 0.65 (0.10 to 2.77) | 0.09 to 2.99 | Unclear | |
| Maridebart cafraglutide 420 mg injection every 4 weeks MARI_SC_420MG_Q4W | 0.66 (0.01 to 49.25) | 0.01 to 51.87 | Unclear | |
| Maridebart cafraglutide 140 mg injection every 4 weeks MARI_SC_140MG_Q4W | 0.66 (0.01 to 50.87) | 0.01 to 50.56 | Unclear | |
| Exenatide extended release and dapagliflozin 2 to 10 mg injection once weekly EXENER_SC_2-10MG_QW | 0.66 (0.09 to 4.01) | 0.09 to 4.21 | Unclear | |
| Efpeglenatide 4 mg subcutaneous once weekly EFPE_SC_4MG_QW | 0.68 (0.15 to 2.88) | 0.13 to 3.07 | Unclear | |
| TG103 15 mg injection once weekly TG103_SC_15MG_QW | 0.68 (0.01 to 56.64) | 0.01 to 54.65 | Unclear | |
| TG103 22.5 mg injection once weekly TG103_SC_22p5MG_QW | 0.69 (0.01 to 56.45) | 0.01 to 58.45 | Unclear | |
| TG103 30 mg injection once weekly TG103_SC_30MG_QW | 0.69 (0.01 to 53.74) | 0.01 to 55.42 | Unclear | |
| CT-388 7.5 mg injection once weekly CT388_SC_7p5MG_QW | 0.70 (0.01 to 57.03) | 0.01 to 57.20 | Unclear | |
| Maridebart cafraglutide 280 mg injection every 4 weeks MARI_SC_280MG_Q4W | 0.71 (0.01 to 57.12) | 0.01 to 61.91 | Unclear | |
| Lotiglipron 20 mg tablet once daily LOTI_PO_20MG_QD | 0.79 (0.16 to 2.92) | 0.15 to 3.12 | Unclear | |
| VCT220 80 mg tablet once daily VCT220_PO_80MG_QD | 0.85 (0.06 to 9.39) | 0.06 to 9.87 | Unclear | |
| VCT220 120 mg tablet once daily VCT220_PO_120MG_QD | 0.88 (0.06 to 9.69) | 0.06 to 10.19 | Unclear | |
| Vct220 po 160mg qd VCT220_PO_160MG_QD | 0.89 (0.06 to 9.57) | 0.05 to 10.25 | Unclear | |
| VK2735 2.5 mg injection once weekly VK2735_SC_2p5MG_QW | 0.96 (0.06 to 9.48) | 0.06 to 9.86 | Unclear | |
| Semaglutide and bimagrumab 2.4 to 30 mg injection once weekly BIMASEMA_SC_2p4-30MG_QW | 1.07 (0.23 to 3.89) | 0.21 to 4.22 | Unclear | |
| Semaglutide and bimagrumab 2.4 to 10 mg injection once weekly BIMASEMA_SC_2p4-10MG_QW | 1.09 (0.23 to 4.03) | 0.21 to 4.31 | Unclear | |
| Aleniglipron 90 mg tablet once daily ALENIG_PO_90MG_QD | 1.31 (0.32 to 5.85) | 0.29 to 6.26 | Unclear | |
| Lotiglipron 160 mg tablet once daily LOTI_PO_160MG_QD | 1.37 (0.38 to 4.26) | 0.33 to 4.74 | Unclear | |
| Semaglutide 14 mg oral once daily (original tablet) SEMA_PO_14MG_QD | 1.37 (0.38 to 4.31) | 0.34 to 4.78 | Unclear | |
| Cagrilintide OTHER_ACTIVE_cagrilintide | 1.62 (0.52 to 6.10) | 0.46 to 6.99 | Unclear | |
| Efpeglenatide 6 mg injection every 2 weeks EFPE_SC_6MG_Q2W | 1.67 (0.50 to 5.89) | 0.46 to 6.30 | Unclear | |
| HRS-7535 30 mg tablet once daily HRS7535_PO_30MG_QD | 1.82 (0.10 to 24.68) | 0.09 to 27.11 | Unclear | |
| HRS-7535 60 mg tablet once daily HRS7535_PO_60MG_QD | 1.83 (0.10 to 25.86) | 0.09 to 26.99 | Unclear | |
| TERN-601 250 mg tablet once daily TERN60_PO_250MG_QD | 1.88 (0.31 to 13.14) | 0.29 to 13.72 | Unclear | |
| Aleniglipron 120 mg tablet once daily ALENIG_PO_120MG_QD | 1.91 (0.53 to 7.87) | 0.48 to 8.48 | Unclear | |
| Semaglutide 2.4 mg subcutaneous once weekly SEMA_SC_2p4MG_QW | 2.01 (1.15 to 3.41) | 0.92 to 4.17 | Worse | |
| Semaglutide and bimagrumab 1.0 to 10 mg injection once weekly BIMASEMA_SC_1p0-10MG_QW | 2.28 (0.65 to 7.36) | 0.59 to 8.09 | Unclear | |
| Aleniglipron 45 mg tablet once daily ALENIG_PO_45MG_QD | 2.32 (0.60 to 9.36) | 0.53 to 10.40 | Unclear | |
| Efpeglenatide 8 mg injection every 2 weeks EFPE_SC_8MG_Q2W | 2.41 (0.78 to 8.18) | 0.71 to 8.93 | Unclear | |
| Tern60 po 500mg qd TERN60_PO_500MG_QD | 2.43 (0.52 to 13.87) | 0.49 to 14.72 | Unclear | |
| Semaglutide and bimagrumab 1.0 to 30 mg injection once weekly BIMASEMA_SC_1p0-30MG_QW | 2.73 (0.85 to 8.26) | 0.78 to 9.29 | Unclear | |
| Efpeglenatide 6 mg subcutaneous once weekly EFPE_SC_6MG_QW | 2.75 (0.88 to 9.51) | 0.80 to 9.93 | Unclear | |
| Lotiglipron 40 mg tablet once daily LOTI_PO_40MG_QD | 3.33 (1.15 to 9.16) | 1.02 to 10.12 | Worse | |
| Liraglutide 3.0 mg subcutaneous once daily LIRA_SC_3p0MG_QD | 3.39 (1.08 to 13.07) | 0.97 to 13.86 | Worse | |
| Lotiglipron 80 mg tablet once daily LOTI_PO_80MG_QD | 3.47 (1.37 to 8.99) | 1.18 to 10.06 | Worse | |
| Bimagrumab OTHER_ACTIVE_bimagrumab | 4.18 (1.60 to 11.20) | 1.38 to 12.40 | Worse | |
| Mazdutide 16 mg injection once weekly MAZD_SC_16MG_QW | 4.29 (0.34 to 137) | 0.32 to 136 | Unclear | |
| TERN-601 750 mg tablet once daily TERN60_PO_750MG_QD | 4.30 (0.90 to 25.30) | 0.80 to 27.29 | Unclear | |
| VK2735 10 mg injection once weekly VK2735_SC_10MG_QW | 4.43 (0.71 to 31.52) | 0.67 to 33.12 | Unclear | |
| VK2735 5.0 mg injection once weekly VK2735_SC_5p0MG_QW | 4.62 (0.79 to 34.07) | 0.74 to 35.32 | Unclear | |
| Mazdutide 4.5 mg subcutaneous once weekly MAZD_SC_4p5MG_QW | 4.90 (0.18 to 151) | 0.18 to 162 | Unclear | |
| Danuglipron 80 mg oral twice daily DANU_PO_80MG_BID | 4.98 (1.02 to 36.09) | 0.97 to 37.94 | Worse | |
| Tirzepatide subcutaneous once weekly, maximum tolerated dose: 10 or 15 mg TIRZ_SC_MTD_QW | 5.13 (2.10 to 13.78) | 1.80 to 15.50 | Worse | |
| Lotiglipron 260 mg tablet once daily LOTI_PO_260MG_QD | 6.83 (2.72 to 17.00) | 2.39 to 19.45 | Worse | |
| Lotiglipron 140 mg tablet once daily LOTI_PO_140MG_QD | 7.09 (2.72 to 18.55) | 2.31 to 21.02 | Worse | |
| HRS-7535 180 mg tablet once daily HRS7535_PO_180MG_QD | 7.24 (0.76 to 82.67) | 0.72 to 88.95 | Unclear | |
| Loti po 200mg qd LOTI_PO_200MG_QD | 7.29 (2.86 to 18.04) | 2.53 to 20.64 | Worse | |
| VK2735 15 mg injection once weekly VK2735_SC_15MG_QW | 9.02 (1.68 to 61.86) | 1.60 to 65.39 | Worse | |
| Danuglipron 140 mg tablet twice daily DANU_PO_140MG_BID | 10.38 (2.34 to 69.66) | 2.14 to 74.91 | Worse | |
| Danuglipron 200 mg oral twice daily DANU_PO_200MG_BID | 12.84 (2.86 to 87.69) | 2.63 to 94.21 | Worse |
Ranking
League table
| Row versus column | PLACEBO | HRS7535_PO_120MG_QD | STANDARD_CARE | MAZD_SC_3MG_QW | MAZD_SC_6MG_QW | TIRZ_SC_MTD_5-10-15_QW | EXEN_SC_5UG_BID | CT388_SC_12MG_QW | SEMA_SC_1p0MG_QW | MARI_SC_420MG_Q4W | MARI_SC_140MG_Q4W | EXENER_SC_2-10MG_QW | EFPE_SC_4MG_QW | TG103_SC_15MG_QW | TG103_SC_22p5MG_QW | TG103_SC_30MG_QW | CT388_SC_7p5MG_QW | MARI_SC_280MG_Q4W | LOTI_PO_20MG_QD | VCT220_PO_80MG_QD | VCT220_PO_120MG_QD | VCT220_PO_160MG_QD | VK2735_SC_2p5MG_QW | BIMASEMA_SC_2p4-30MG_QW | BIMASEMA_SC_2p4-10MG_QW | ALENIG_PO_90MG_QD | LOTI_PO_160MG_QD | SEMA_PO_14MG_QD | OTHER_ACTIVE_cagrilintide | EFPE_SC_6MG_Q2W | HRS7535_PO_30MG_QD | HRS7535_PO_60MG_QD | TERN60_PO_250MG_QD | ALENIG_PO_120MG_QD | SEMA_SC_2p4MG_QW | BIMASEMA_SC_1p0-10MG_QW | ALENIG_PO_45MG_QD | EFPE_SC_8MG_Q2W | TERN60_PO_500MG_QD | BIMASEMA_SC_1p0-30MG_QW | EFPE_SC_6MG_QW | LOTI_PO_40MG_QD | LIRA_SC_3p0MG_QD | LOTI_PO_80MG_QD | OTHER_ACTIVE_bimagrumab | MAZD_SC_16MG_QW | TERN60_PO_750MG_QD | VK2735_SC_10MG_QW | VK2735_SC_5p0MG_QW | MAZD_SC_4p5MG_QW | DANU_PO_80MG_BID | TIRZ_SC_MTD_QW | LOTI_PO_260MG_QD | LOTI_PO_140MG_QD | HRS7535_PO_180MG_QD | LOTI_PO_200MG_QD | VK2735_SC_15MG_QW | DANU_PO_140MG_BID | DANU_PO_200MG_BID |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PLACEBO | PLACEBO | 4.01 0.16 to 230 | 2.67 0.14 to 53.90 | 2.46 0.06 to 200 | 2.38 0.06 to 174 | 2.02 0.11 to 40.47 | 1.75 0.02 to 173 | 1.64 0.02 to 153 | 1.53 0.36 to 10.17 | 1.52 0.02 to 183 | 1.51 0.02 to 169 | 1.50 0.25 to 10.53 | 1.47 0.35 to 6.82 | 1.47 0.02 to 156 | 1.45 0.02 to 177 | 1.44 0.02 to 157 | 1.42 0.02 to 155 | 1.40 0.02 to 173 | 1.26 0.34 to 6.07 | 1.17 0.11 to 16.68 | 1.14 0.10 to 16.31 | 1.13 0.10 to 17.05 | 1.04 0.11 to 15.62 | 0.94 0.26 to 4.39 | 0.92 0.25 to 4.40 | 0.76 0.17 to 3.16 | 0.73 0.23 to 2.66 | 0.73 0.23 to 2.64 | 0.62 0.16 to 1.91 | 0.60 0.17 to 2.00 | 0.55 0.04 to 9.97 | 0.55 0.04 to 10.39 | 0.53 0.08 to 3.20 | 0.52 0.13 to 1.90 | 0.50 0.29 to 0.87 | 0.44 0.14 to 1.55 | 0.43 0.11 to 1.66 | 0.41 0.12 to 1.29 | 0.41 0.07 to 1.91 | 0.37 0.12 to 1.18 | 0.36 0.11 to 1.13 | 0.30 0.11 to 0.87 | 0.30 0.08 to 0.93 | 0.29 0.11 to 0.73 | 0.24 0.09 to 0.63 | 0.23 0.01 to 2.94 | 0.23 0.04 to 1.11 | 0.23 0.03 to 1.40 | 0.22 0.03 to 1.27 | 0.20 0.01 to 5.42 | 0.20 0.03 to 0.98 | 0.19 0.07 to 0.48 | 0.15 0.06 to 0.37 | 0.14 0.05 to 0.37 | 0.14 0.01 to 1.32 | 0.14 0.06 to 0.35 | 0.11 0.02 to 0.60 | 0.10 0.01 to 0.43 | 0.08 0.01 to 0.35 |
| HRS7535_PO_120MG_QD | 0.25 0.00 to 6.22 | HRS7535_PO_120MG_QD | 0.62 0.01 to 52.36 | 0.61 0.00 to 143 | 0.59 0.00 to 140 | 0.47 0.00 to 39.09 | 0.40 0.00 to 146 | 0.40 0.00 to 113 | 0.40 0.01 to 15.75 | 0.37 0.00 to 108 | 0.36 0.00 to 117 | 0.37 0.00 to 16.14 | 0.37 0.01 to 12.85 | 0.36 0.00 to 111 | 0.35 0.00 to 125 | 0.33 0.00 to 116 | 0.34 0.00 to 98.99 | 0.33 0.00 to 118 | 0.32 0.00 to 11.11 | 0.29 0.00 to 20.17 | 0.28 0.00 to 18.72 | 0.29 0.00 to 17.97 | 0.27 0.00 to 17.11 | 0.24 0.00 to 7.71 | 0.23 0.00 to 8.19 | 0.19 0.00 to 6.23 | 0.19 0.00 to 5.47 | 0.18 0.00 to 5.91 | 0.15 0.00 to 4.69 | 0.15 0.00 to 4.55 | 0.14 0.00 to 6.07 | 0.14 0.00 to 6.04 | 0.13 0.00 to 5.08 | 0.13 0.00 to 3.98 | 0.13 0.00 to 3.24 | 0.11 0.00 to 3.43 | 0.10 0.00 to 3.53 | 0.10 0.00 to 3.06 | 0.10 0.00 to 3.43 | 0.09 0.00 to 2.68 | 0.09 0.00 to 2.63 | 0.08 0.00 to 2.05 | 0.07 0.00 to 2.25 | 0.07 0.00 to 2.01 | 0.06 0.00 to 1.72 | 0.05 0.00 to 3.55 | 0.06 0.00 to 1.97 | 0.05 0.00 to 2.12 | 0.05 0.00 to 2.17 | 0.05 0.00 to 5.44 | 0.05 0.00 to 1.74 | 0.05 0.00 to 1.39 | 0.04 0.00 to 0.99 | 0.04 0.00 to 0.98 | 0.04 0.00 to 0.89 | 0.03 0.00 to 0.96 | 0.03 0.00 to 0.98 | 0.02 0.00 to 0.79 | 0.02 0.00 to 0.67 |
| STANDARD_CARE | 0.37 0.02 to 7.15 | 1.62 0.02 to 193 | STANDARD_CARE | 0.94 0.01 to 180 | 0.93 0.01 to 154 | 0.75 0.29 to 1.95 | 0.67 0.00 to 137 | 0.65 0.00 to 138 | 0.61 0.02 to 16.28 | 0.60 0.00 to 159 | 0.58 0.00 to 144 | 0.57 0.02 to 19.27 | 0.58 0.02 to 15.74 | 0.57 0.00 to 145 | 0.57 0.00 to 136 | 0.54 0.00 to 141 | 0.55 0.00 to 131 | 0.54 0.00 to 156 | 0.49 0.02 to 12.52 | 0.45 0.01 to 23.36 | 0.44 0.01 to 21.01 | 0.44 0.01 to 19.84 | 0.42 0.01 to 19.59 | 0.37 0.01 to 9.71 | 0.36 0.01 to 9.56 | 0.29 0.01 to 7.44 | 0.28 0.01 to 6.80 | 0.28 0.01 to 6.88 | 0.23 0.01 to 5.48 | 0.23 0.01 to 5.44 | 0.21 0.00 to 12.26 | 0.22 0.00 to 12.12 | 0.20 0.01 to 6.24 | 0.19 0.01 to 4.74 | 0.19 0.01 to 3.73 | 0.17 0.01 to 3.97 | 0.16 0.01 to 4.15 | 0.15 0.01 to 3.57 | 0.15 0.00 to 4.33 | 0.14 0.01 to 3.33 | 0.14 0.01 to 2.99 | 0.12 0.00 to 2.60 | 0.11 0.00 to 2.70 | 0.11 0.00 to 2.23 | 0.09 0.00 to 1.96 | 0.08 0.00 to 4.62 | 0.08 0.00 to 2.32 | 0.09 0.00 to 2.65 | 0.08 0.00 to 2.46 | 0.08 0.00 to 6.70 | 0.07 0.00 to 2.21 | 0.07 0.00 to 1.63 | 0.05 0.00 to 1.17 | 0.05 0.00 to 1.17 | 0.05 0.00 to 2.17 | 0.05 0.00 to 1.09 | 0.04 0.00 to 1.19 | 0.03 0.00 to 0.99 | 0.03 0.00 to 0.79 |
| MAZD_SC_3MG_QW | 0.41 0.01 to 16.58 | 1.64 0.01 to 405 | 1.07 0.01 to 135 | MAZD_SC_3MG_QW | 0.95 0.00 to 230 | 0.78 0.00 to 105 | 0.67 0.00 to 262 | 0.65 0.00 to 245 | 0.65 0.01 to 39.19 | 0.58 0.00 to 230 | 0.60 0.00 to 217 | 0.62 0.01 to 40.19 | 0.62 0.01 to 33.57 | 0.58 0.00 to 247 | 0.56 0.00 to 259 | 0.60 0.00 to 235 | 0.57 0.00 to 236 | 0.55 0.00 to 301 | 0.53 0.01 to 30.03 | 0.47 0.00 to 49.99 | 0.46 0.00 to 48.50 | 0.45 0.00 to 53.14 | 0.43 0.00 to 46.56 | 0.39 0.00 to 20.69 | 0.38 0.00 to 18.96 | 0.30 0.00 to 19.02 | 0.30 0.00 to 15.47 | 0.31 0.00 to 16.54 | 0.24 0.00 to 12.26 | 0.24 0.00 to 12.29 | 0.21 0.00 to 23.95 | 0.21 0.00 to 27.75 | 0.20 0.00 to 14.62 | 0.21 0.00 to 11.56 | 0.20 0.00 to 9.00 | 0.17 0.00 to 9.77 | 0.17 0.00 to 9.71 | 0.16 0.00 to 7.99 | 0.16 0.00 to 10.06 | 0.15 0.00 to 7.29 | 0.14 0.00 to 7.24 | 0.13 0.00 to 5.72 | 0.12 0.00 to 6.03 | 0.12 0.00 to 5.35 | 0.10 0.00 to 4.59 | 0.08 0.00 to 8.45 | 0.09 0.00 to 5.61 | 0.09 0.00 to 6.24 | 0.08 0.00 to 5.58 | 0.08 0.00 to 6.55 | 0.08 0.00 to 5.18 | 0.08 0.00 to 3.53 | 0.06 0.00 to 2.92 | 0.06 0.00 to 2.75 | 0.05 0.00 to 4.25 | 0.06 0.00 to 2.79 | 0.04 0.00 to 2.75 | 0.04 0.00 to 2.26 | 0.03 0.00 to 1.95 |
| MAZD_SC_6MG_QW | 0.42 0.01 to 16.02 | 1.71 0.01 to 420 | 1.08 0.01 to 127 | 1.06 0.00 to 220 | MAZD_SC_6MG_QW | 0.81 0.00 to 94.43 | 0.68 0.00 to 257 | 0.64 0.00 to 233 | 0.68 0.01 to 38.93 | 0.59 0.00 to 269 | 0.63 0.00 to 238 | 0.64 0.01 to 46.20 | 0.65 0.01 to 30.82 | 0.61 0.00 to 227 | 0.61 0.00 to 266 | 0.59 0.00 to 229 | 0.57 0.00 to 207 | 0.60 0.00 to 233 | 0.56 0.01 to 27.54 | 0.50 0.00 to 43.87 | 0.48 0.00 to 41.90 | 0.48 0.00 to 45.83 | 0.45 0.00 to 41.23 | 0.41 0.00 to 20.97 | 0.41 0.00 to 20.47 | 0.33 0.00 to 15.76 | 0.31 0.00 to 14.79 | 0.31 0.00 to 14.71 | 0.25 0.00 to 11.96 | 0.26 0.00 to 11.70 | 0.23 0.00 to 23.09 | 0.23 0.00 to 23.19 | 0.22 0.00 to 13.68 | 0.22 0.00 to 10.11 | 0.21 0.00 to 8.20 | 0.19 0.00 to 8.62 | 0.18 0.00 to 8.53 | 0.17 0.00 to 8.13 | 0.17 0.00 to 9.78 | 0.16 0.00 to 6.35 | 0.15 0.00 to 6.85 | 0.13 0.00 to 5.77 | 0.12 0.00 to 5.61 | 0.12 0.00 to 4.95 | 0.10 0.00 to 4.24 | 0.09 0.00 to 8.95 | 0.10 0.00 to 5.67 | 0.09 0.00 to 5.68 | 0.09 0.00 to 5.43 | 0.09 0.00 to 6.44 | 0.08 0.00 to 4.61 | 0.08 0.00 to 3.42 | 0.06 0.00 to 2.60 | 0.06 0.00 to 2.44 | 0.06 0.00 to 4.34 | 0.06 0.00 to 2.52 | 0.04 0.00 to 2.66 | 0.04 0.00 to 2.14 | 0.03 0.00 to 1.69 |
| TIRZ_SC_MTD_5-10-15_QW | 0.49 0.02 to 9.38 | 2.12 0.03 to 262 | 1.33 0.51 to 3.44 | 1.28 0.01 to 262 | 1.23 0.01 to 217 | TIRZ_SC_MTD_5-10-15_QW | 0.88 0.00 to 173 | 0.86 0.00 to 199 | 0.80 0.03 to 22.45 | 0.78 0.00 to 229 | 0.76 0.00 to 189 | 0.76 0.02 to 27.36 | 0.76 0.03 to 20.15 | 0.75 0.00 to 184 | 0.75 0.00 to 200 | 0.72 0.00 to 191 | 0.70 0.00 to 178 | 0.71 0.00 to 213 | 0.64 0.02 to 16.80 | 0.61 0.01 to 32.56 | 0.58 0.01 to 28.68 | 0.60 0.01 to 28.71 | 0.57 0.01 to 25.46 | 0.50 0.02 to 12.41 | 0.48 0.02 to 13.36 | 0.38 0.01 to 9.85 | 0.37 0.01 to 9.22 | 0.37 0.01 to 9.22 | 0.30 0.01 to 7.53 | 0.30 0.01 to 7.23 | 0.28 0.01 to 16.95 | 0.28 0.00 to 15.94 | 0.26 0.01 to 8.28 | 0.26 0.01 to 6.38 | 0.25 0.01 to 4.99 | 0.22 0.01 to 5.45 | 0.21 0.01 to 5.17 | 0.21 0.01 to 4.93 | 0.20 0.01 to 5.77 | 0.18 0.01 to 4.11 | 0.18 0.01 to 4.24 | 0.15 0.01 to 3.48 | 0.15 0.01 to 3.75 | 0.14 0.01 to 3.14 | 0.12 0.00 to 2.61 | 0.11 0.00 to 6.23 | 0.11 0.00 to 3.24 | 0.12 0.00 to 3.52 | 0.11 0.00 to 3.19 | 0.10 0.00 to 9.08 | 0.09 0.00 to 2.80 | 0.10 0.00 to 2.11 | 0.07 0.00 to 1.56 | 0.07 0.00 to 1.54 | 0.07 0.00 to 2.84 | 0.07 0.00 to 1.47 | 0.06 0.00 to 1.55 | 0.05 0.00 to 1.30 | 0.04 0.00 to 1.03 |
| EXEN_SC_5UG_BID | 0.57 0.01 to 43.47 | 2.47 0.01 to 987 | 1.50 0.01 to 294 | 1.50 0.00 to 623 | 1.46 0.00 to 565 | 1.14 0.01 to 227 | EXEN_SC_5UG_BID | 0.98 0.00 to 503 | 0.92 0.01 to 96.24 | 0.90 0.00 to 518 | 0.89 0.00 to 511 | 0.88 0.01 to 110 | 0.88 0.01 to 85.64 | 0.89 0.00 to 567 | 0.89 0.00 to 531 | 0.87 0.00 to 436 | 0.86 0.00 to 459 | 0.84 0.00 to 428 | 0.77 0.01 to 73.77 | 0.71 0.00 to 93.63 | 0.67 0.00 to 96.44 | 0.66 0.00 to 100 | 0.62 0.00 to 91.99 | 0.56 0.01 to 50.79 | 0.54 0.00 to 53.09 | 0.42 0.00 to 41.73 | 0.43 0.00 to 38.29 | 0.43 0.00 to 38.37 | 0.35 0.00 to 31.19 | 0.34 0.00 to 28.21 | 0.32 0.00 to 63.00 | 0.32 0.00 to 58.19 | 0.30 0.00 to 29.19 | 0.30 0.00 to 29.05 | 0.29 0.00 to 22.31 | 0.25 0.00 to 21.89 | 0.24 0.00 to 22.72 | 0.23 0.00 to 21.12 | 0.24 0.00 to 19.81 | 0.21 0.00 to 17.94 | 0.21 0.00 to 18.35 | 0.18 0.00 to 14.08 | 0.17 0.00 to 14.87 | 0.16 0.00 to 13.81 | 0.14 0.00 to 10.84 | 0.13 0.00 to 21.94 | 0.13 0.00 to 12.71 | 0.13 0.00 to 13.68 | 0.13 0.00 to 12.16 | 0.12 0.00 to 23.18 | 0.11 0.00 to 11.47 | 0.11 0.00 to 8.72 | 0.08 0.00 to 6.69 | 0.08 0.00 to 6.78 | 0.08 0.00 to 10.54 | 0.08 0.00 to 6.37 | 0.06 0.00 to 6.66 | 0.05 0.00 to 5.51 | 0.04 0.00 to 4.24 |
| CT388_SC_12MG_QW | 0.61 0.01 to 42.01 | 2.49 0.01 to 794 | 1.53 0.01 to 336 | 1.53 0.00 to 570 | 1.56 0.00 to 532 | 1.16 0.01 to 245 | 1.02 0.00 to 574 | CT388_SC_12MG_QW | 0.97 0.01 to 96.98 | 0.94 0.00 to 545 | 0.93 0.00 to 503 | 0.91 0.01 to 95.55 | 0.90 0.01 to 82.73 | 0.86 0.00 to 480 | 0.87 0.00 to 504 | 0.90 0.00 to 486 | 0.86 0.00 to 451 | 0.85 0.00 to 480 | 0.76 0.01 to 71.39 | 0.74 0.00 to 95.46 | 0.70 0.00 to 108 | 0.70 0.00 to 107 | 0.65 0.00 to 90.69 | 0.58 0.01 to 53.39 | 0.57 0.01 to 49.12 | 0.45 0.00 to 40.08 | 0.45 0.00 to 36.78 | 0.44 0.00 to 37.89 | 0.36 0.00 to 31.16 | 0.37 0.00 to 28.26 | 0.34 0.00 to 57.28 | 0.32 0.00 to 57.50 | 0.32 0.00 to 30.83 | 0.31 0.00 to 25.10 | 0.30 0.00 to 21.01 | 0.26 0.00 to 21.03 | 0.26 0.00 to 21.60 | 0.25 0.00 to 20.30 | 0.25 0.00 to 21.36 | 0.22 0.00 to 17.82 | 0.22 0.00 to 17.77 | 0.18 0.00 to 15.17 | 0.17 0.00 to 14.62 | 0.17 0.00 to 12.66 | 0.14 0.00 to 10.84 | 0.13 0.00 to 21.70 | 0.13 0.00 to 13.43 | 0.14 0.00 to 14.34 | 0.13 0.00 to 13.23 | 0.12 0.00 to 28.31 | 0.11 0.00 to 9.95 | 0.11 0.00 to 9.33 | 0.09 0.00 to 6.41 | 0.09 0.00 to 6.33 | 0.08 0.00 to 9.63 | 0.08 0.00 to 6.23 | 0.07 0.00 to 6.52 | 0.06 0.00 to 4.86 | 0.04 0.00 to 3.77 |
| SEMA_SC_1p0MG_QW | 0.65 0.10 to 2.77 | 2.50 0.06 to 183 | 1.63 0.06 to 46.71 | 1.53 0.03 to 157 | 1.47 0.03 to 156 | 1.25 0.04 to 36.26 | 1.08 0.01 to 131 | 1.03 0.01 to 124 | SEMA_SC_1p0MG_QW | 0.93 0.01 to 140 | 0.93 0.01 to 132 | 0.95 0.07 to 11.40 | 0.94 0.09 to 8.17 | 0.91 0.01 to 121 | 0.89 0.01 to 143 | 0.91 0.01 to 122 | 0.90 0.01 to 116 | 0.86 0.01 to 139 | 0.82 0.08 to 6.61 | 0.74 0.04 to 17.66 | 0.72 0.04 to 14.77 | 0.73 0.03 to 15.91 | 0.66 0.04 to 14.44 | 0.61 0.08 to 3.85 | 0.59 0.08 to 3.92 | 0.48 0.05 to 3.78 | 0.47 0.05 to 3.31 | 0.47 0.05 to 3.42 | 0.39 0.04 to 2.64 | 0.38 0.04 to 2.58 | 0.35 0.01 to 8.75 | 0.33 0.01 to 8.74 | 0.32 0.02 to 3.53 | 0.33 0.03 to 2.35 | 0.33 0.05 to 1.41 | 0.28 0.04 to 1.41 | 0.27 0.03 to 2.09 | 0.26 0.03 to 1.76 | 0.26 0.02 to 2.23 | 0.24 0.03 to 1.10 | 0.23 0.03 to 1.49 | 0.19 0.02 to 1.17 | 0.19 0.02 to 1.24 | 0.18 0.02 to 1.05 | 0.15 0.02 to 0.62 | 0.14 0.00 to 2.82 | 0.15 0.01 to 1.34 | 0.14 0.01 to 1.51 | 0.14 0.01 to 1.37 | 0.13 0.00 to 4.57 | 0.12 0.01 to 1.12 | 0.12 0.02 to 0.72 | 0.09 0.01 to 0.54 | 0.09 0.01 to 0.52 | 0.09 0.00 to 1.26 | 0.09 0.01 to 0.50 | 0.07 0.01 to 0.67 | 0.06 0.00 to 0.50 | 0.05 0.00 to 0.40 |
| MARI_SC_420MG_Q4W | 0.66 0.01 to 49.25 | 2.72 0.01 to 1007 | 1.68 0.01 to 351 | 1.72 0.00 to 659 | 1.69 0.00 to 648 | 1.28 0.00 to 279 | 1.12 0.00 to 595 | 1.06 0.00 to 577 | 1.07 0.01 to 123 | MARI_SC_420MG_Q4W | 0.99 0.00 to 490 | 1.00 0.01 to 114 | 0.97 0.01 to 102 | 0.95 0.00 to 538 | 0.96 0.00 to 543 | 0.99 0.00 to 503 | 0.98 0.00 to 476 | 0.91 0.00 to 506 | 0.87 0.01 to 88.94 | 0.78 0.00 to 109 | 0.74 0.00 to 134 | 0.73 0.00 to 123 | 0.69 0.00 to 117 | 0.63 0.00 to 60.00 | 0.62 0.00 to 66.03 | 0.49 0.00 to 47.30 | 0.49 0.00 to 44.93 | 0.50 0.00 to 45.26 | 0.40 0.00 to 36.40 | 0.37 0.00 to 37.72 | 0.37 0.00 to 64.62 | 0.36 0.00 to 68.14 | 0.35 0.00 to 38.47 | 0.33 0.00 to 29.04 | 0.33 0.00 to 27.44 | 0.29 0.00 to 27.70 | 0.28 0.00 to 24.77 | 0.26 0.00 to 23.97 | 0.26 0.00 to 27.16 | 0.23 0.00 to 20.54 | 0.23 0.00 to 22.08 | 0.20 0.00 to 18.20 | 0.19 0.00 to 17.00 | 0.18 0.00 to 17.22 | 0.15 0.00 to 13.06 | 0.14 0.00 to 25.87 | 0.15 0.00 to 15.37 | 0.14 0.00 to 17.75 | 0.14 0.00 to 16.18 | 0.13 0.00 to 33.11 | 0.12 0.00 to 12.68 | 0.13 0.00 to 10.18 | 0.09 0.00 to 8.43 | 0.09 0.00 to 8.60 | 0.09 0.00 to 12.27 | 0.09 0.00 to 8.01 | 0.07 0.00 to 8.61 | 0.06 0.00 to 5.91 | 0.05 0.00 to 4.74 |
| MARI_SC_140MG_Q4W | 0.66 0.01 to 50.87 | 2.76 0.01 to 939 | 1.72 0.01 to 337 | 1.66 0.00 to 679 | 1.59 0.00 to 711 | 1.31 0.01 to 259 | 1.12 0.00 to 675 | 1.08 0.00 to 558 | 1.07 0.01 to 115 | 1.01 0.00 to 552 | MARI_SC_140MG_Q4W | 1.06 0.01 to 112 | 0.99 0.01 to 105 | 0.99 0.00 to 615 | 1.02 0.00 to 650 | 0.95 0.00 to 600 | 1.00 0.00 to 530 | 0.94 0.00 to 432 | 0.88 0.01 to 76.92 | 0.82 0.00 to 140 | 0.75 0.00 to 136 | 0.78 0.00 to 130 | 0.72 0.00 to 114 | 0.65 0.00 to 61.88 | 0.62 0.00 to 62.63 | 0.49 0.00 to 46.89 | 0.49 0.00 to 45.47 | 0.49 0.00 to 46.17 | 0.40 0.00 to 37.10 | 0.39 0.00 to 37.51 | 0.36 0.00 to 57.73 | 0.35 0.00 to 62.85 | 0.35 0.00 to 38.16 | 0.34 0.00 to 31.00 | 0.34 0.00 to 25.78 | 0.29 0.00 to 26.93 | 0.28 0.00 to 25.01 | 0.27 0.00 to 23.58 | 0.27 0.00 to 26.56 | 0.25 0.00 to 22.81 | 0.24 0.00 to 21.54 | 0.21 0.00 to 17.28 | 0.19 0.00 to 17.41 | 0.19 0.00 to 16.07 | 0.16 0.00 to 13.43 | 0.14 0.00 to 27.30 | 0.15 0.00 to 15.66 | 0.15 0.00 to 16.61 | 0.14 0.00 to 16.47 | 0.13 0.00 to 28.94 | 0.12 0.00 to 14.68 | 0.13 0.00 to 11.07 | 0.10 0.00 to 8.14 | 0.09 0.00 to 7.51 | 0.09 0.00 to 11.57 | 0.09 0.00 to 7.55 | 0.07 0.00 to 8.38 | 0.06 0.00 to 6.63 | 0.05 0.00 to 5.22 |
| EXENER_SC_2-10MG_QW | 0.66 0.09 to 4.01 | 2.69 0.06 to 229 | 1.74 0.05 to 55.66 | 1.62 0.02 to 182 | 1.57 0.02 to 178 | 1.32 0.04 to 43.16 | 1.14 0.01 to 157 | 1.10 0.01 to 143 | 1.05 0.09 to 13.43 | 1.00 0.01 to 159 | 0.95 0.01 to 150 | EXENER_SC_2-10MG_QW | 0.98 0.09 to 10.06 | 0.96 0.01 to 150 | 0.97 0.01 to 147 | 0.93 0.01 to 148 | 0.93 0.01 to 154 | 0.94 0.01 to 155 | 0.84 0.08 to 9.34 | 0.78 0.04 to 17.57 | 0.76 0.04 to 17.98 | 0.75 0.04 to 17.97 | 0.71 0.03 to 16.58 | 0.63 0.06 to 6.68 | 0.62 0.06 to 6.33 | 0.50 0.05 to 4.96 | 0.49 0.05 to 4.20 | 0.48 0.05 to 4.33 | 0.40 0.04 to 3.39 | 0.39 0.04 to 3.56 | 0.36 0.01 to 10.48 | 0.35 0.01 to 11.25 | 0.34 0.02 to 4.44 | 0.34 0.03 to 3.15 | 0.33 0.04 to 2.15 | 0.29 0.03 to 2.46 | 0.28 0.03 to 2.62 | 0.27 0.03 to 2.28 | 0.27 0.02 to 2.77 | 0.24 0.03 to 1.99 | 0.24 0.03 to 2.07 | 0.20 0.02 to 1.63 | 0.19 0.02 to 1.65 | 0.19 0.02 to 1.45 | 0.16 0.02 to 1.20 | 0.15 0.00 to 3.27 | 0.15 0.01 to 1.57 | 0.15 0.01 to 1.95 | 0.14 0.01 to 1.75 | 0.13 0.00 to 5.43 | 0.13 0.01 to 1.47 | 0.13 0.01 to 0.95 | 0.09 0.01 to 0.75 | 0.09 0.01 to 0.74 | 0.09 0.00 to 1.54 | 0.09 0.01 to 0.72 | 0.07 0.00 to 0.85 | 0.06 0.00 to 0.69 | 0.05 0.00 to 0.54 |
| EFPE_SC_4MG_QW | 0.68 0.15 to 2.88 | 2.74 0.08 to 192 | 1.74 0.06 to 49.12 | 1.62 0.03 to 167 | 1.55 0.03 to 154 | 1.32 0.05 to 36.55 | 1.14 0.01 to 135 | 1.11 0.01 to 126 | 1.07 0.12 to 10.87 | 1.03 0.01 to 148 | 1.01 0.01 to 139 | 1.02 0.10 to 10.88 | EFPE_SC_4MG_QW | 0.97 0.01 to 124 | 0.99 0.01 to 148 | 0.99 0.01 to 121 | 0.96 0.01 to 131 | 0.95 0.01 to 140 | 0.85 0.11 to 6.91 | 0.78 0.05 to 15.08 | 0.76 0.05 to 15.54 | 0.76 0.05 to 15.58 | 0.71 0.05 to 14.22 | 0.64 0.09 to 5.27 | 0.63 0.08 to 4.92 | 0.51 0.06 to 3.95 | 0.49 0.07 to 3.34 | 0.49 0.07 to 3.34 | 0.40 0.05 to 2.73 | 0.41 0.08 to 1.58 | 0.37 0.02 to 9.38 | 0.36 0.02 to 8.92 | 0.35 0.03 to 3.41 | 0.34 0.04 to 2.34 | 0.34 0.07 to 1.59 | 0.29 0.04 to 1.97 | 0.29 0.04 to 2.03 | 0.28 0.06 to 0.97 | 0.27 0.03 to 2.33 | 0.25 0.04 to 1.61 | 0.25 0.06 to 0.86 | 0.20 0.03 to 1.23 | 0.20 0.03 to 1.23 | 0.19 0.03 to 1.04 | 0.16 0.03 to 0.89 | 0.15 0.00 to 2.69 | 0.15 0.02 to 1.33 | 0.15 0.01 to 1.49 | 0.15 0.01 to 1.45 | 0.14 0.00 to 4.75 | 0.13 0.01 to 1.21 | 0.13 0.02 to 0.71 | 0.10 0.02 to 0.54 | 0.09 0.02 to 0.53 | 0.09 0.01 to 1.35 | 0.09 0.02 to 0.50 | 0.07 0.01 to 0.68 | 0.06 0.01 to 0.53 | 0.05 0.00 to 0.44 |
| TG103_SC_15MG_QW | 0.68 0.01 to 56.64 | 2.80 0.01 to 1208 | 1.76 0.01 to 377 | 1.73 0.00 to 845 | 1.65 0.00 to 763 | 1.34 0.01 to 307 | 1.13 0.00 to 749 | 1.16 0.00 to 612 | 1.10 0.01 to 126 | 1.05 0.00 to 633 | 1.01 0.00 to 591 | 1.04 0.01 to 127 | 1.03 0.01 to 108 | TG103_SC_15MG_QW | 0.98 0.00 to 585 | 0.95 0.00 to 664 | 0.96 0.00 to 543 | 0.94 0.00 to 540 | 0.87 0.01 to 95.93 | 0.80 0.00 to 144 | 0.79 0.00 to 132 | 0.79 0.00 to 132 | 0.75 0.00 to 126 | 0.64 0.01 to 66.71 | 0.64 0.01 to 64.37 | 0.52 0.00 to 51.81 | 0.51 0.00 to 50.75 | 0.50 0.00 to 47.06 | 0.41 0.00 to 39.81 | 0.40 0.00 to 34.94 | 0.36 0.00 to 71.39 | 0.37 0.00 to 71.07 | 0.35 0.00 to 38.21 | 0.34 0.00 to 34.09 | 0.34 0.00 to 27.08 | 0.30 0.00 to 27.98 | 0.29 0.00 to 30.12 | 0.28 0.00 to 26.27 | 0.28 0.00 to 28.29 | 0.25 0.00 to 21.74 | 0.24 0.00 to 23.03 | 0.21 0.00 to 17.89 | 0.20 0.00 to 17.51 | 0.20 0.00 to 16.52 | 0.16 0.00 to 13.50 | 0.14 0.00 to 24.60 | 0.15 0.00 to 16.30 | 0.16 0.00 to 18.36 | 0.14 0.00 to 17.43 | 0.13 0.00 to 33.19 | 0.13 0.00 to 13.99 | 0.13 0.00 to 11.23 | 0.10 0.00 to 8.78 | 0.10 0.00 to 8.12 | 0.09 0.00 to 13.83 | 0.09 0.00 to 8.41 | 0.08 0.00 to 8.62 | 0.06 0.00 to 6.83 | 0.05 0.00 to 5.26 |
| TG103_SC_22p5MG_QW | 0.69 0.01 to 56.45 | 2.86 0.01 to 983 | 1.75 0.01 to 406 | 1.78 0.00 to 746 | 1.64 0.00 to 864 | 1.34 0.01 to 320 | 1.12 0.00 to 706 | 1.15 0.00 to 613 | 1.12 0.01 to 130 | 1.04 0.00 to 753 | 0.98 0.00 to 662 | 1.03 0.01 to 117 | 1.01 0.01 to 104 | 1.02 0.00 to 592 | TG103_SC_22p5MG_QW | 0.99 0.00 to 534 | 1.05 0.00 to 675 | 0.93 0.00 to 688 | 0.89 0.01 to 89.47 | 0.82 0.00 to 142 | 0.76 0.00 to 136 | 0.80 0.00 to 138 | 0.75 0.00 to 126 | 0.65 0.00 to 66.99 | 0.64 0.00 to 70.94 | 0.52 0.00 to 52.66 | 0.52 0.00 to 49.95 | 0.50 0.00 to 48.18 | 0.41 0.00 to 41.64 | 0.41 0.00 to 40.83 | 0.38 0.00 to 71.79 | 0.37 0.00 to 81.20 | 0.35 0.00 to 43.62 | 0.35 0.00 to 33.81 | 0.35 0.00 to 27.72 | 0.30 0.00 to 30.30 | 0.30 0.00 to 27.84 | 0.28 0.00 to 28.03 | 0.27 0.00 to 30.82 | 0.25 0.00 to 24.30 | 0.25 0.00 to 24.17 | 0.21 0.00 to 20.94 | 0.20 0.00 to 21.39 | 0.20 0.00 to 17.78 | 0.16 0.00 to 14.90 | 0.15 0.00 to 25.36 | 0.15 0.00 to 18.19 | 0.16 0.00 to 18.53 | 0.15 0.00 to 16.83 | 0.13 0.00 to 33.48 | 0.13 0.00 to 13.44 | 0.13 0.00 to 13.06 | 0.10 0.00 to 9.23 | 0.10 0.00 to 8.85 | 0.09 0.00 to 13.32 | 0.10 0.00 to 8.60 | 0.07 0.00 to 8.28 | 0.06 0.00 to 6.74 | 0.05 0.00 to 5.17 |
| TG103_SC_30MG_QW | 0.69 0.01 to 53.74 | 3.02 0.01 to 1050 | 1.84 0.01 to 362 | 1.67 0.00 to 926 | 1.69 0.00 to 652 | 1.38 0.01 to 261 | 1.16 0.00 to 587 | 1.11 0.00 to 637 | 1.10 0.01 to 122 | 1.01 0.00 to 586 | 1.05 0.00 to 623 | 1.07 0.01 to 134 | 1.01 0.01 to 95.03 | 1.05 0.00 to 641 | 1.01 0.00 to 536 | TG103_SC_30MG_QW | 0.96 0.00 to 617 | 0.99 0.00 to 622 | 0.86 0.01 to 87.87 | 0.79 0.00 to 133 | 0.79 0.00 to 104 | 0.80 0.00 to 136 | 0.75 0.00 to 124 | 0.67 0.01 to 62.69 | 0.66 0.01 to 58.69 | 0.52 0.00 to 49.03 | 0.51 0.00 to 47.27 | 0.50 0.00 to 44.34 | 0.41 0.00 to 38.17 | 0.41 0.00 to 37.55 | 0.39 0.00 to 66.45 | 0.37 0.00 to 65.03 | 0.35 0.00 to 43.34 | 0.35 0.00 to 32.94 | 0.35 0.00 to 27.67 | 0.31 0.00 to 24.23 | 0.29 0.00 to 27.43 | 0.28 0.00 to 26.44 | 0.27 0.00 to 28.88 | 0.25 0.00 to 22.73 | 0.24 0.00 to 23.26 | 0.20 0.00 to 17.86 | 0.19 0.00 to 18.67 | 0.19 0.00 to 16.31 | 0.16 0.00 to 14.24 | 0.15 0.00 to 24.54 | 0.16 0.00 to 16.92 | 0.15 0.00 to 18.13 | 0.15 0.00 to 17.86 | 0.13 0.00 to 30.70 | 0.13 0.00 to 13.99 | 0.13 0.00 to 11.62 | 0.10 0.00 to 8.41 | 0.10 0.00 to 8.25 | 0.09 0.00 to 12.65 | 0.09 0.00 to 7.74 | 0.07 0.00 to 8.06 | 0.06 0.00 to 6.61 | 0.05 0.00 to 5.38 |
| CT388_SC_7p5MG_QW | 0.70 0.01 to 57.03 | 2.97 0.01 to 1161 | 1.82 0.01 to 382 | 1.74 0.00 to 885 | 1.76 0.00 to 797 | 1.42 0.01 to 256 | 1.16 0.00 to 688 | 1.17 0.00 to 511 | 1.11 0.01 to 124 | 1.02 0.00 to 633 | 1.00 0.00 to 598 | 1.08 0.01 to 141 | 1.04 0.01 to 105 | 1.05 0.00 to 608 | 0.96 0.00 to 614 | 1.05 0.00 to 670 | CT388_SC_7p5MG_QW | 0.99 0.00 to 570 | 0.89 0.01 to 97.88 | 0.81 0.00 to 127 | 0.81 0.00 to 131 | 0.78 0.00 to 126 | 0.77 0.00 to 130 | 0.67 0.01 to 69.86 | 0.62 0.01 to 64.73 | 0.53 0.00 to 53.22 | 0.53 0.00 to 49.84 | 0.52 0.00 to 50.37 | 0.41 0.00 to 40.76 | 0.41 0.00 to 39.40 | 0.37 0.00 to 60.42 | 0.38 0.00 to 78.41 | 0.35 0.00 to 42.57 | 0.36 0.00 to 36.89 | 0.35 0.00 to 29.16 | 0.30 0.00 to 29.42 | 0.30 0.00 to 30.49 | 0.28 0.00 to 27.36 | 0.28 0.00 to 31.00 | 0.26 0.00 to 24.90 | 0.25 0.00 to 22.51 | 0.22 0.00 to 17.97 | 0.21 0.00 to 18.52 | 0.20 0.00 to 18.51 | 0.16 0.00 to 14.58 | 0.15 0.00 to 24.14 | 0.16 0.00 to 17.26 | 0.15 0.00 to 17.87 | 0.15 0.00 to 17.42 | 0.14 0.00 to 34.15 | 0.13 0.00 to 14.81 | 0.14 0.00 to 11.46 | 0.10 0.00 to 8.96 | 0.10 0.00 to 8.63 | 0.10 0.00 to 12.88 | 0.10 0.00 to 8.35 | 0.07 0.00 to 8.34 | 0.06 0.00 to 6.94 | 0.05 0.00 to 5.54 |
| MARI_SC_280MG_Q4W | 0.71 0.01 to 57.12 | 3.04 0.01 to 1024 | 1.86 0.01 to 404 | 1.83 0.00 to 851 | 1.67 0.00 to 832 | 1.40 0.00 to 299 | 1.19 0.00 to 706 | 1.17 0.00 to 546 | 1.17 0.01 to 130 | 1.09 0.00 to 656 | 1.06 0.00 to 600 | 1.07 0.01 to 125 | 1.05 0.01 to 123 | 1.06 0.00 to 552 | 1.07 0.00 to 758 | 1.01 0.00 to 672 | 1.01 0.00 to 584 | MARI_SC_280MG_Q4W | 0.92 0.01 to 91.37 | 0.87 0.00 to 138 | 0.81 0.00 to 117 | 0.80 0.00 to 130 | 0.77 0.00 to 129 | 0.69 0.00 to 61.84 | 0.67 0.00 to 74.11 | 0.55 0.00 to 53.68 | 0.54 0.00 to 48.47 | 0.53 0.00 to 44.53 | 0.43 0.00 to 39.49 | 0.42 0.00 to 40.27 | 0.39 0.00 to 73.56 | 0.38 0.00 to 77.18 | 0.37 0.00 to 46.18 | 0.37 0.00 to 34.49 | 0.35 0.00 to 27.60 | 0.31 0.00 to 30.56 | 0.30 0.00 to 31.57 | 0.29 0.00 to 27.94 | 0.29 0.00 to 30.02 | 0.26 0.00 to 24.58 | 0.25 0.00 to 24.10 | 0.21 0.00 to 18.94 | 0.20 0.00 to 19.03 | 0.20 0.00 to 17.56 | 0.17 0.00 to 15.16 | 0.15 0.00 to 27.40 | 0.16 0.00 to 16.90 | 0.16 0.00 to 17.72 | 0.15 0.00 to 17.41 | 0.14 0.00 to 34.03 | 0.13 0.00 to 14.91 | 0.14 0.00 to 11.88 | 0.10 0.00 to 8.71 | 0.10 0.00 to 8.58 | 0.09 0.00 to 12.36 | 0.10 0.00 to 8.28 | 0.08 0.00 to 7.98 | 0.07 0.00 to 7.09 | 0.05 0.00 to 5.23 |
| LOTI_PO_20MG_QD | 0.79 0.16 to 2.92 | 3.10 0.09 to 210 | 2.06 0.08 to 58.92 | 1.89 0.03 to 176 | 1.79 0.04 to 157 | 1.56 0.06 to 46.38 | 1.31 0.01 to 170 | 1.31 0.01 to 140 | 1.23 0.15 to 12.16 | 1.15 0.01 to 170 | 1.14 0.01 to 157 | 1.19 0.11 to 12.45 | 1.18 0.14 to 8.74 | 1.15 0.01 to 151 | 1.12 0.01 to 161 | 1.16 0.01 to 159 | 1.12 0.01 to 141 | 1.09 0.01 to 161 | LOTI_PO_20MG_QD | 0.92 0.05 to 17.94 | 0.88 0.05 to 16.24 | 0.88 0.05 to 17.79 | 0.83 0.05 to 16.47 | 0.74 0.10 to 5.53 | 0.73 0.10 to 5.24 | 0.59 0.07 to 4.15 | 0.58 0.11 to 2.65 | 0.59 0.11 to 2.57 | 0.48 0.06 to 2.79 | 0.46 0.07 to 2.87 | 0.42 0.02 to 10.13 | 0.42 0.02 to 10.55 | 0.41 0.04 to 3.90 | 0.40 0.05 to 2.56 | 0.39 0.08 to 1.65 | 0.34 0.05 to 2.07 | 0.34 0.04 to 2.11 | 0.32 0.05 to 1.79 | 0.32 0.03 to 2.44 | 0.28 0.04 to 1.64 | 0.28 0.04 to 1.64 | 0.24 0.05 to 0.87 | 0.23 0.03 to 1.34 | 0.23 0.05 to 0.73 | 0.18 0.03 to 0.94 | 0.17 0.00 to 3.28 | 0.18 0.02 to 1.40 | 0.17 0.01 to 1.68 | 0.17 0.01 to 1.56 | 0.16 0.00 to 5.37 | 0.15 0.01 to 1.18 | 0.15 0.03 to 0.75 | 0.12 0.03 to 0.38 | 0.11 0.03 to 0.37 | 0.11 0.01 to 1.39 | 0.11 0.03 to 0.35 | 0.09 0.01 to 0.73 | 0.07 0.01 to 0.56 | 0.06 0.01 to 0.46 |
| VCT220_PO_80MG_QD | 0.85 0.06 to 9.39 | 3.44 0.05 to 390 | 2.21 0.04 to 104 | 2.12 0.02 to 301 | 1.99 0.02 to 280 | 1.63 0.03 to 79.05 | 1.41 0.01 to 245 | 1.35 0.01 to 243 | 1.35 0.06 to 28.37 | 1.29 0.01 to 234 | 1.22 0.01 to 265 | 1.28 0.06 to 26.29 | 1.28 0.07 to 21.32 | 1.25 0.01 to 226 | 1.21 0.01 to 269 | 1.27 0.01 to 246 | 1.23 0.01 to 221 | 1.15 0.01 to 253 | 1.09 0.06 to 18.27 | VCT220_PO_80MG_QD | 0.96 0.05 to 18.30 | 0.95 0.05 to 19.71 | 0.90 0.03 to 31.63 | 0.83 0.04 to 13.54 | 0.80 0.04 to 13.71 | 0.65 0.03 to 10.84 | 0.63 0.03 to 9.78 | 0.63 0.03 to 9.90 | 0.51 0.03 to 7.81 | 0.51 0.03 to 7.45 | 0.46 0.01 to 17.61 | 0.45 0.01 to 22.04 | 0.43 0.02 to 9.23 | 0.43 0.02 to 6.72 | 0.43 0.03 to 5.08 | 0.37 0.02 to 5.35 | 0.36 0.02 to 5.63 | 0.34 0.02 to 5.17 | 0.34 0.01 to 6.33 | 0.32 0.02 to 4.34 | 0.30 0.02 to 4.27 | 0.26 0.01 to 3.47 | 0.24 0.01 to 3.72 | 0.24 0.01 to 3.15 | 0.20 0.01 to 2.55 | 0.19 0.00 to 6.50 | 0.19 0.01 to 3.54 | 0.18 0.01 to 3.66 | 0.18 0.01 to 3.71 | 0.17 0.00 to 9.86 | 0.16 0.01 to 2.96 | 0.16 0.01 to 2.15 | 0.12 0.01 to 1.61 | 0.12 0.01 to 1.57 | 0.12 0.00 to 3.10 | 0.12 0.01 to 1.50 | 0.09 0.00 to 1.79 | 0.08 0.00 to 1.39 | 0.06 0.00 to 1.14 |
| VCT220_PO_120MG_QD | 0.88 0.06 to 9.69 | 3.59 0.05 to 386 | 2.26 0.05 to 118 | 2.18 0.02 to 314 | 2.08 0.02 to 288 | 1.74 0.03 to 86.51 | 1.49 0.01 to 272 | 1.43 0.01 to 237 | 1.39 0.07 to 28.26 | 1.35 0.01 to 267 | 1.34 0.01 to 292 | 1.32 0.06 to 28.32 | 1.32 0.06 to 21.89 | 1.27 0.01 to 251 | 1.31 0.01 to 253 | 1.27 0.01 to 237 | 1.24 0.01 to 221 | 1.23 0.01 to 270 | 1.13 0.06 to 18.69 | 1.04 0.05 to 19.28 | VCT220_PO_120MG_QD | 1.00 0.05 to 20.78 | 0.96 0.03 to 33.58 | 0.83 0.04 to 14.97 | 0.82 0.04 to 13.79 | 0.66 0.03 to 10.92 | 0.66 0.04 to 10.09 | 0.65 0.04 to 9.83 | 0.53 0.03 to 7.63 | 0.53 0.03 to 7.28 | 0.48 0.01 to 17.85 | 0.47 0.01 to 20.94 | 0.47 0.02 to 8.99 | 0.44 0.02 to 6.97 | 0.44 0.03 to 5.06 | 0.39 0.02 to 5.94 | 0.37 0.02 to 5.99 | 0.37 0.02 to 5.11 | 0.36 0.02 to 6.30 | 0.32 0.02 to 4.54 | 0.32 0.02 to 4.39 | 0.27 0.02 to 3.72 | 0.25 0.01 to 3.87 | 0.25 0.02 to 3.29 | 0.21 0.01 to 2.73 | 0.19 0.00 to 7.03 | 0.20 0.01 to 3.56 | 0.19 0.01 to 3.89 | 0.19 0.01 to 3.55 | 0.17 0.00 to 9.78 | 0.17 0.01 to 3.24 | 0.17 0.01 to 2.26 | 0.13 0.01 to 1.66 | 0.13 0.01 to 1.68 | 0.12 0.00 to 3.01 | 0.12 0.01 to 1.57 | 0.09 0.00 to 1.75 | 0.08 0.00 to 1.55 | 0.07 0.00 to 1.25 |
| VCT220_PO_160MG_QD | 0.89 0.06 to 9.57 | 3.50 0.06 to 372 | 2.25 0.05 to 108 | 2.24 0.02 to 301 | 2.10 0.02 to 253 | 1.66 0.03 to 80.81 | 1.51 0.01 to 295 | 1.43 0.01 to 227 | 1.37 0.06 to 29.23 | 1.37 0.01 to 262 | 1.28 0.01 to 269 | 1.34 0.06 to 28.42 | 1.32 0.06 to 20.42 | 1.27 0.01 to 257 | 1.25 0.01 to 292 | 1.25 0.01 to 235 | 1.28 0.01 to 228 | 1.25 0.01 to 239 | 1.14 0.06 to 18.87 | 1.05 0.05 to 18.78 | 1.00 0.05 to 18.97 | VCT220_PO_160MG_QD | 0.95 0.03 to 34.53 | 0.85 0.04 to 14.02 | 0.81 0.04 to 13.87 | 0.66 0.03 to 10.75 | 0.66 0.04 to 9.76 | 0.66 0.03 to 9.90 | 0.52 0.03 to 7.35 | 0.53 0.03 to 7.52 | 0.48 0.01 to 19.58 | 0.47 0.01 to 19.45 | 0.46 0.02 to 9.33 | 0.44 0.02 to 6.47 | 0.45 0.03 to 5.05 | 0.38 0.02 to 5.64 | 0.37 0.02 to 6.17 | 0.37 0.02 to 5.16 | 0.36 0.02 to 5.98 | 0.33 0.02 to 4.43 | 0.32 0.02 to 4.56 | 0.27 0.01 to 3.77 | 0.26 0.01 to 3.58 | 0.26 0.01 to 3.35 | 0.21 0.01 to 2.76 | 0.20 0.00 to 7.12 | 0.20 0.01 to 3.38 | 0.20 0.01 to 3.86 | 0.19 0.01 to 3.74 | 0.18 0.00 to 11.37 | 0.17 0.01 to 2.97 | 0.17 0.01 to 2.22 | 0.13 0.01 to 1.72 | 0.13 0.01 to 1.67 | 0.12 0.00 to 3.20 | 0.12 0.01 to 1.67 | 0.10 0.00 to 1.82 | 0.08 0.00 to 1.38 | 0.07 0.00 to 1.15 |
| VK2735_SC_2p5MG_QW | 0.96 0.06 to 9.48 | 3.75 0.06 to 369 | 2.38 0.05 to 129 | 2.33 0.02 to 309 | 2.22 0.02 to 262 | 1.75 0.04 to 101 | 1.62 0.01 to 244 | 1.54 0.01 to 234 | 1.51 0.07 to 26.10 | 1.45 0.01 to 281 | 1.39 0.01 to 271 | 1.40 0.06 to 28.72 | 1.40 0.07 to 21.00 | 1.33 0.01 to 276 | 1.33 0.01 to 273 | 1.34 0.01 to 246 | 1.29 0.01 to 238 | 1.30 0.01 to 316 | 1.20 0.06 to 18.28 | 1.11 0.03 to 35.42 | 1.04 0.03 to 33.35 | 1.05 0.03 to 37.42 | VK2735_SC_2p5MG_QW | 0.92 0.04 to 14.37 | 0.88 0.04 to 13.40 | 0.72 0.04 to 10.17 | 0.70 0.04 to 8.80 | 0.70 0.04 to 9.03 | 0.57 0.03 to 7.46 | 0.57 0.03 to 7.35 | 0.50 0.01 to 19.59 | 0.50 0.01 to 20.79 | 0.49 0.02 to 9.67 | 0.48 0.02 to 6.88 | 0.47 0.03 to 4.97 | 0.41 0.02 to 5.57 | 0.40 0.02 to 6.10 | 0.39 0.02 to 4.92 | 0.38 0.02 to 6.47 | 0.34 0.02 to 4.30 | 0.34 0.02 to 4.33 | 0.29 0.02 to 3.30 | 0.27 0.01 to 3.61 | 0.27 0.02 to 3.01 | 0.22 0.01 to 2.60 | 0.21 0.00 to 6.45 | 0.21 0.01 to 3.44 | 0.22 0.01 to 1.65 | 0.21 0.01 to 1.69 | 0.18 0.00 to 10.23 | 0.18 0.01 to 2.93 | 0.18 0.01 to 2.18 | 0.14 0.01 to 1.54 | 0.13 0.01 to 1.52 | 0.13 0.00 to 3.18 | 0.13 0.01 to 1.47 | 0.11 0.01 to 0.71 | 0.09 0.00 to 1.37 | 0.07 0.00 to 1.11 |
| BIMASEMA_SC_2p4-30MG_QW | 1.07 0.23 to 3.89 | 4.21 0.13 to 279 | 2.73 0.10 to 74.01 | 2.59 0.05 to 255 | 2.44 0.05 to 227 | 2.01 0.08 to 59.21 | 1.77 0.02 to 197 | 1.72 0.02 to 193 | 1.64 0.26 to 12.75 | 1.58 0.02 to 227 | 1.55 0.02 to 211 | 1.59 0.15 to 16.53 | 1.55 0.19 to 11.65 | 1.56 0.01 to 180 | 1.53 0.01 to 213 | 1.49 0.02 to 194 | 1.50 0.01 to 188 | 1.46 0.02 to 206 | 1.35 0.18 to 9.90 | 1.21 0.07 to 25.86 | 1.20 0.07 to 22.47 | 1.18 0.07 to 24.80 | 1.09 0.07 to 22.31 | BIMASEMA_SC_2p4-30MG_QW | 0.97 0.17 to 5.55 | 0.79 0.10 to 5.64 | 0.78 0.11 to 4.79 | 0.78 0.11 to 4.87 | 0.64 0.08 to 3.67 | 0.62 0.09 to 3.77 | 0.57 0.03 to 13.11 | 0.56 0.03 to 14.44 | 0.55 0.05 to 5.36 | 0.54 0.07 to 3.42 | 0.53 0.11 to 1.92 | 0.46 0.09 to 1.98 | 0.44 0.06 to 2.96 | 0.43 0.06 to 2.41 | 0.43 0.04 to 3.19 | 0.39 0.08 to 1.53 | 0.38 0.06 to 2.17 | 0.31 0.05 to 1.70 | 0.31 0.04 to 1.75 | 0.30 0.05 to 1.49 | 0.26 0.06 to 0.83 | 0.23 0.01 to 4.44 | 0.24 0.02 to 1.97 | 0.23 0.02 to 2.22 | 0.23 0.02 to 2.09 | 0.21 0.00 to 7.20 | 0.20 0.02 to 1.65 | 0.20 0.03 to 1.00 | 0.15 0.03 to 0.75 | 0.15 0.03 to 0.73 | 0.14 0.01 to 2.04 | 0.14 0.02 to 0.70 | 0.11 0.01 to 1.03 | 0.10 0.01 to 0.77 | 0.08 0.01 to 0.60 |
| BIMASEMA_SC_2p4-10MG_QW | 1.09 0.23 to 4.03 | 4.30 0.12 to 295 | 2.77 0.10 to 73.53 | 2.66 0.05 to 231 | 2.42 0.05 to 222 | 2.09 0.07 to 56.13 | 1.87 0.02 to 214 | 1.75 0.02 to 196 | 1.70 0.26 to 12.69 | 1.61 0.02 to 216 | 1.61 0.02 to 226 | 1.62 0.16 to 17.11 | 1.59 0.20 to 11.98 | 1.55 0.02 to 196 | 1.56 0.01 to 249 | 1.51 0.02 to 195 | 1.60 0.02 to 198 | 1.50 0.01 to 244 | 1.38 0.19 to 10.38 | 1.25 0.07 to 26.50 | 1.22 0.07 to 22.76 | 1.24 0.07 to 23.61 | 1.14 0.07 to 22.80 | 1.03 0.18 to 5.83 | BIMASEMA_SC_2p4-10MG_QW | 0.81 0.10 to 5.93 | 0.79 0.12 to 5.03 | 0.80 0.11 to 5.03 | 0.64 0.09 to 3.83 | 0.64 0.09 to 4.06 | 0.59 0.03 to 13.35 | 0.57 0.03 to 15.12 | 0.55 0.05 to 5.22 | 0.55 0.07 to 3.45 | 0.54 0.11 to 2.00 | 0.48 0.09 to 1.95 | 0.45 0.06 to 3.07 | 0.43 0.06 to 2.61 | 0.43 0.04 to 3.43 | 0.40 0.08 to 1.54 | 0.39 0.06 to 2.22 | 0.32 0.05 to 1.73 | 0.31 0.04 to 1.84 | 0.31 0.05 to 1.48 | 0.26 0.06 to 0.86 | 0.24 0.01 to 4.61 | 0.25 0.02 to 1.97 | 0.24 0.02 to 2.26 | 0.23 0.02 to 2.15 | 0.21 0.01 to 7.52 | 0.21 0.02 to 1.68 | 0.21 0.03 to 1.05 | 0.16 0.03 to 0.79 | 0.15 0.03 to 0.75 | 0.14 0.01 to 1.96 | 0.15 0.03 to 0.74 | 0.12 0.01 to 1.06 | 0.10 0.01 to 0.79 | 0.08 0.01 to 0.62 |
| ALENIG_PO_90MG_QD | 1.31 0.32 to 5.85 | 5.32 0.16 to 386 | 3.51 0.13 to 88.02 | 3.34 0.05 to 328 | 3.06 0.06 to 280 | 2.66 0.10 to 69.62 | 2.36 0.02 to 273 | 2.22 0.02 to 247 | 2.08 0.26 to 20.92 | 2.04 0.02 to 276 | 2.02 0.02 to 269 | 2.00 0.20 to 20.94 | 1.96 0.25 to 15.51 | 1.94 0.02 to 271 | 1.94 0.02 to 282 | 1.93 0.02 to 249 | 1.89 0.02 to 253 | 1.81 0.02 to 272 | 1.68 0.24 to 13.59 | 1.55 0.09 to 28.94 | 1.51 0.09 to 32.40 | 1.53 0.09 to 33.21 | 1.39 0.10 to 28.49 | 1.26 0.18 to 10.24 | 1.24 0.17 to 9.79 | ALENIG_PO_90MG_QD | 0.98 0.15 to 6.71 | 0.96 0.15 to 6.85 | 0.80 0.11 to 5.39 | 0.79 0.11 to 5.42 | 0.71 0.04 to 19.00 | 0.69 0.03 to 19.25 | 0.68 0.06 to 7.03 | 0.67 0.19 to 2.37 | 0.65 0.14 to 3.15 | 0.57 0.09 to 3.94 | 0.56 0.14 to 2.07 | 0.54 0.08 to 3.40 | 0.54 0.06 to 4.49 | 0.49 0.08 to 3.03 | 0.47 0.07 to 2.98 | 0.40 0.07 to 2.41 | 0.38 0.05 to 2.62 | 0.37 0.07 to 2.08 | 0.31 0.05 to 1.78 | 0.30 0.01 to 5.92 | 0.30 0.03 to 2.64 | 0.29 0.03 to 3.15 | 0.28 0.02 to 2.85 | 0.27 0.01 to 9.93 | 0.26 0.02 to 2.21 | 0.25 0.05 to 1.45 | 0.19 0.04 to 1.08 | 0.18 0.03 to 1.02 | 0.18 0.01 to 2.69 | 0.18 0.03 to 1.03 | 0.14 0.01 to 1.34 | 0.12 0.01 to 1.04 | 0.10 0.01 to 0.83 |
| LOTI_PO_160MG_QD | 1.37 0.38 to 4.26 | 5.33 0.18 to 341 | 3.61 0.15 to 94.25 | 3.32 0.06 to 320 | 3.18 0.07 to 274 | 2.74 0.11 to 68.08 | 2.34 0.03 to 254 | 2.21 0.03 to 228 | 2.11 0.30 to 19.06 | 2.06 0.02 to 291 | 2.05 0.02 to 276 | 2.06 0.24 to 19.76 | 2.03 0.30 to 14.01 | 1.96 0.02 to 243 | 1.93 0.02 to 293 | 1.95 0.02 to 230 | 1.90 0.02 to 243 | 1.87 0.02 to 271 | 1.72 0.38 to 8.71 | 1.59 0.10 to 29.86 | 1.53 0.10 to 28.30 | 1.51 0.10 to 28.44 | 1.43 0.11 to 26.17 | 1.28 0.21 to 8.99 | 1.27 0.20 to 8.36 | 1.02 0.15 to 6.58 | LOTI_PO_160MG_QD | 1.00 0.25 to 3.82 | 0.82 0.13 to 4.43 | 0.81 0.14 to 4.44 | 0.73 0.04 to 17.21 | 0.73 0.04 to 16.28 | 0.69 0.07 to 5.97 | 0.70 0.11 to 4.14 | 0.68 0.17 to 2.43 | 0.60 0.10 to 3.06 | 0.58 0.09 to 3.47 | 0.55 0.10 to 2.78 | 0.55 0.06 to 3.89 | 0.49 0.09 to 2.45 | 0.49 0.09 to 2.54 | 0.41 0.12 to 1.30 | 0.40 0.06 to 2.08 | 0.39 0.12 to 1.08 | 0.33 0.06 to 1.38 | 0.31 0.01 to 5.10 | 0.31 0.04 to 2.22 | 0.30 0.03 to 2.71 | 0.29 0.03 to 2.47 | 0.27 0.01 to 8.90 | 0.27 0.03 to 1.88 | 0.26 0.05 to 1.17 | 0.20 0.06 to 0.54 | 0.19 0.06 to 0.55 | 0.19 0.01 to 2.28 | 0.19 0.06 to 0.50 | 0.15 0.02 to 1.15 | 0.13 0.01 to 0.86 | 0.10 0.01 to 0.69 |
| SEMA_PO_14MG_QD | 1.37 0.38 to 4.31 | 5.41 0.17 to 330 | 3.54 0.15 to 91.54 | 3.26 0.06 to 312 | 3.22 0.07 to 261 | 2.70 0.11 to 71.61 | 2.33 0.03 to 271 | 2.26 0.03 to 239 | 2.15 0.29 to 18.80 | 2.02 0.02 to 299 | 2.04 0.02 to 287 | 2.06 0.23 to 20.85 | 2.06 0.30 to 14.24 | 2.01 0.02 to 232 | 1.99 0.02 to 282 | 1.98 0.02 to 250 | 1.93 0.02 to 225 | 1.90 0.02 to 282 | 1.71 0.39 to 9.21 | 1.59 0.10 to 29.10 | 1.55 0.10 to 28.04 | 1.52 0.10 to 29.67 | 1.43 0.11 to 27.42 | 1.29 0.21 to 8.85 | 1.25 0.20 to 8.87 | 1.04 0.15 to 6.78 | 1.00 0.26 to 3.95 | SEMA_PO_14MG_QD | 0.83 0.13 to 4.41 | 0.82 0.14 to 4.38 | 0.73 0.04 to 16.92 | 0.73 0.04 to 16.85 | 0.71 0.07 to 6.34 | 0.70 0.11 to 4.12 | 0.68 0.17 to 2.48 | 0.60 0.11 to 3.07 | 0.59 0.09 to 3.42 | 0.56 0.10 to 2.92 | 0.56 0.07 to 3.94 | 0.49 0.09 to 2.53 | 0.49 0.09 to 2.52 | 0.42 0.12 to 1.28 | 0.40 0.06 to 2.07 | 0.39 0.12 to 1.10 | 0.32 0.07 to 1.47 | 0.31 0.01 to 5.54 | 0.31 0.04 to 2.24 | 0.31 0.03 to 2.69 | 0.29 0.03 to 2.50 | 0.28 0.01 to 8.96 | 0.27 0.03 to 1.92 | 0.26 0.05 to 1.16 | 0.20 0.06 to 0.54 | 0.19 0.06 to 0.56 | 0.19 0.01 to 2.33 | 0.19 0.06 to 0.51 | 0.15 0.02 to 1.18 | 0.13 0.01 to 0.91 | 0.11 0.01 to 0.72 |
| OTHER_ACTIVE_cagrilintide | 1.62 0.52 to 6.10 | 6.80 0.21 to 440 | 4.43 0.18 to 123 | 4.21 0.08 to 358 | 3.95 0.08 to 364 | 3.35 0.13 to 92.65 | 2.88 0.03 to 349 | 2.76 0.03 to 293 | 2.59 0.38 to 24.50 | 2.53 0.03 to 349 | 2.50 0.03 to 331 | 2.52 0.30 to 25.97 | 2.48 0.37 to 18.34 | 2.44 0.03 to 329 | 2.44 0.02 to 331 | 2.46 0.03 to 293 | 2.42 0.02 to 306 | 2.33 0.03 to 355 | 2.10 0.36 to 16.19 | 1.96 0.13 to 37.36 | 1.89 0.13 to 33.90 | 1.91 0.14 to 35.53 | 1.74 0.13 to 36.18 | 1.55 0.27 to 12.01 | 1.55 0.26 to 11.30 | 1.25 0.19 to 9.23 | 1.21 0.23 to 7.81 | 1.21 0.23 to 7.80 | OTHER_ACTIVE_cagrilintide | 0.98 0.17 to 6.19 | 0.92 0.05 to 20.83 | 0.89 0.05 to 21.53 | 0.87 0.09 to 8.10 | 0.85 0.14 to 5.50 | 0.81 0.23 to 3.53 | 0.73 0.14 to 4.31 | 0.69 0.11 to 4.78 | 0.68 0.12 to 3.98 | 0.67 0.08 to 4.89 | 0.60 0.12 to 3.52 | 0.59 0.11 to 3.50 | 0.50 0.10 to 2.67 | 0.48 0.19 to 1.28 | 0.46 0.11 to 2.49 | 0.39 0.09 to 1.95 | 0.38 0.01 to 6.52 | 0.38 0.05 to 3.05 | 0.36 0.04 to 3.60 | 0.36 0.03 to 3.41 | 0.33 0.01 to 10.60 | 0.33 0.03 to 2.60 | 0.32 0.07 to 1.61 | 0.24 0.05 to 1.22 | 0.23 0.05 to 1.22 | 0.23 0.02 to 3.05 | 0.22 0.05 to 1.17 | 0.18 0.02 to 1.54 | 0.16 0.02 to 1.16 | 0.13 0.01 to 0.95 |
| EFPE_SC_6MG_Q2W | 1.67 0.50 to 5.89 | 6.71 0.22 to 477 | 4.44 0.18 to 113 | 4.22 0.08 to 409 | 3.86 0.09 to 351 | 3.31 0.14 to 86.89 | 2.93 0.04 to 338 | 2.73 0.04 to 306 | 2.65 0.39 to 24.16 | 2.68 0.03 to 353 | 2.56 0.03 to 317 | 2.57 0.28 to 25.35 | 2.46 0.63 to 11.85 | 2.48 0.03 to 295 | 2.46 0.02 to 334 | 2.46 0.03 to 304 | 2.42 0.03 to 287 | 2.37 0.02 to 322 | 2.17 0.35 to 14.51 | 1.97 0.13 to 37.09 | 1.87 0.14 to 36.02 | 1.90 0.13 to 37.86 | 1.75 0.14 to 34.14 | 1.61 0.27 to 11.38 | 1.57 0.25 to 11.64 | 1.27 0.18 to 8.91 | 1.24 0.23 to 7.21 | 1.22 0.23 to 7.16 | 1.02 0.16 to 5.80 | EFPE_SC_6MG_Q2W | 0.92 0.05 to 20.28 | 0.90 0.05 to 22.93 | 0.87 0.10 to 7.92 | 0.86 0.14 to 5.51 | 0.83 0.22 to 3.31 | 0.73 0.13 to 4.29 | 0.71 0.11 to 4.63 | 0.69 0.22 to 2.10 | 0.68 0.09 to 4.99 | 0.61 0.11 to 3.42 | 0.61 0.20 to 1.76 | 0.51 0.10 to 2.55 | 0.49 0.08 to 2.63 | 0.48 0.10 to 2.22 | 0.40 0.08 to 1.92 | 0.39 0.01 to 6.65 | 0.39 0.05 to 2.87 | 0.38 0.04 to 3.25 | 0.36 0.04 to 3.26 | 0.34 0.01 to 11.11 | 0.33 0.03 to 2.47 | 0.32 0.07 to 1.52 | 0.24 0.05 to 1.14 | 0.24 0.05 to 1.11 | 0.23 0.01 to 3.05 | 0.23 0.05 to 1.06 | 0.18 0.02 to 1.49 | 0.16 0.02 to 1.17 | 0.13 0.01 to 0.91 |
| HRS7535_PO_30MG_QD | 1.82 0.10 to 24.68 | 6.96 0.16 to 695 | 4.68 0.08 to 268 | 4.70 0.04 to 693 | 4.33 0.04 to 640 | 3.57 0.06 to 193 | 3.17 0.02 to 584 | 2.98 0.02 to 586 | 2.89 0.11 to 68.43 | 2.70 0.02 to 701 | 2.81 0.02 to 555 | 2.80 0.10 to 76.70 | 2.69 0.11 to 59.59 | 2.78 0.01 to 613 | 2.63 0.01 to 616 | 2.57 0.02 to 566 | 2.67 0.02 to 583 | 2.54 0.01 to 593 | 2.39 0.10 to 45.23 | 2.17 0.06 to 82.68 | 2.10 0.06 to 84.24 | 2.08 0.05 to 86.75 | 1.98 0.05 to 75.95 | 1.74 0.08 to 38.11 | 1.69 0.07 to 37.23 | 1.40 0.05 to 27.44 | 1.37 0.06 to 26.63 | 1.36 0.06 to 25.62 | 1.09 0.05 to 20.00 | 1.08 0.05 to 21.51 | HRS7535_PO_30MG_QD | 0.98 0.04 to 24.80 | 0.94 0.03 to 22.85 | 0.93 0.04 to 17.01 | 0.91 0.05 to 13.69 | 0.78 0.04 to 15.68 | 0.78 0.03 to 14.76 | 0.73 0.03 to 13.95 | 0.74 0.03 to 15.48 | 0.67 0.03 to 12.27 | 0.66 0.03 to 12.12 | 0.55 0.03 to 9.47 | 0.53 0.02 to 9.62 | 0.51 0.03 to 8.60 | 0.43 0.02 to 7.48 | 0.40 0.01 to 17.22 | 0.42 0.02 to 8.22 | 0.40 0.01 to 9.89 | 0.39 0.01 to 9.88 | 0.37 0.00 to 24.50 | 0.35 0.01 to 8.08 | 0.35 0.02 to 5.79 | 0.26 0.01 to 4.26 | 0.26 0.01 to 4.17 | 0.26 0.01 to 2.61 | 0.25 0.01 to 4.07 | 0.19 0.01 to 4.50 | 0.17 0.01 to 4.08 | 0.14 0.00 to 3.03 |
| HRS7535_PO_60MG_QD | 1.83 0.10 to 25.86 | 7.08 0.17 to 682 | 4.61 0.08 to 284 | 4.67 0.04 to 740 | 4.43 0.04 to 688 | 3.57 0.06 to 211 | 3.14 0.02 to 646 | 3.12 0.02 to 554 | 3.00 0.11 to 67.07 | 2.79 0.01 to 605 | 2.87 0.02 to 607 | 2.85 0.09 to 78.51 | 2.77 0.11 to 59.53 | 2.72 0.01 to 656 | 2.72 0.01 to 628 | 2.68 0.02 to 625 | 2.64 0.01 to 616 | 2.66 0.01 to 551 | 2.36 0.09 to 52.25 | 2.21 0.05 to 81.30 | 2.11 0.05 to 84.95 | 2.13 0.05 to 84.16 | 2.01 0.05 to 82.45 | 1.78 0.07 to 37.05 | 1.77 0.07 to 34.22 | 1.45 0.05 to 29.43 | 1.37 0.06 to 25.11 | 1.37 0.06 to 25.40 | 1.12 0.05 to 19.79 | 1.11 0.04 to 21.36 | 1.02 0.04 to 24.31 | HRS7535_PO_60MG_QD | 0.95 0.03 to 23.51 | 0.93 0.04 to 18.35 | 0.92 0.05 to 14.34 | 0.81 0.04 to 15.27 | 0.78 0.03 to 15.68 | 0.74 0.03 to 13.69 | 0.75 0.03 to 17.23 | 0.68 0.03 to 11.89 | 0.66 0.03 to 11.70 | 0.56 0.02 to 9.86 | 0.53 0.02 to 9.76 | 0.53 0.02 to 8.70 | 0.44 0.02 to 7.64 | 0.41 0.00 to 17.99 | 0.43 0.01 to 9.13 | 0.41 0.01 to 10.01 | 0.40 0.01 to 9.58 | 0.37 0.00 to 25.49 | 0.36 0.01 to 8.56 | 0.36 0.02 to 6.06 | 0.27 0.01 to 4.39 | 0.26 0.01 to 4.24 | 0.26 0.01 to 2.54 | 0.25 0.01 to 4.23 | 0.20 0.01 to 4.66 | 0.17 0.01 to 4.00 | 0.14 0.00 to 3.25 |
| TERN60_PO_250MG_QD | 1.88 0.31 to 13.14 | 7.72 0.20 to 645 | 5.08 0.16 to 177 | 4.99 0.07 to 504 | 4.57 0.07 to 553 | 3.90 0.12 to 140 | 3.32 0.03 to 442 | 3.17 0.03 to 392 | 3.09 0.28 to 43.11 | 2.88 0.03 to 525 | 2.90 0.03 to 455 | 2.90 0.23 to 45.62 | 2.88 0.29 to 31.20 | 2.89 0.03 to 427 | 2.88 0.02 to 515 | 2.82 0.02 to 502 | 2.86 0.02 to 429 | 2.67 0.02 to 494 | 2.46 0.26 to 27.80 | 2.31 0.11 to 57.70 | 2.12 0.11 to 58.99 | 2.18 0.11 to 53.82 | 2.03 0.10 to 54.16 | 1.83 0.19 to 20.64 | 1.81 0.19 to 20.42 | 1.48 0.14 to 15.60 | 1.45 0.17 to 13.48 | 1.41 0.16 to 13.98 | 1.14 0.12 to 10.59 | 1.15 0.13 to 10.49 | 1.06 0.04 to 33.20 | 1.05 0.04 to 33.58 | TERN60_PO_250MG_QD | 0.98 0.11 to 10.16 | 0.96 0.14 to 6.69 | 0.85 0.10 to 7.84 | 0.81 0.09 to 8.46 | 0.79 0.09 to 7.06 | 0.80 0.15 to 3.20 | 0.69 0.08 to 6.83 | 0.69 0.08 to 6.02 | 0.59 0.07 to 4.79 | 0.56 0.06 to 5.24 | 0.54 0.07 to 4.36 | 0.45 0.06 to 3.77 | 0.43 0.01 to 10.10 | 0.45 0.09 to 1.92 | 0.42 0.03 to 6.09 | 0.41 0.03 to 5.71 | 0.37 0.01 to 18.96 | 0.37 0.03 to 4.56 | 0.37 0.05 to 2.81 | 0.28 0.04 to 2.25 | 0.27 0.03 to 2.21 | 0.26 0.01 to 4.71 | 0.26 0.03 to 2.14 | 0.21 0.01 to 2.63 | 0.18 0.01 to 2.08 | 0.15 0.01 to 1.67 |
| ALENIG_PO_120MG_QD | 1.91 0.53 to 7.87 | 7.91 0.25 to 515 | 5.17 0.21 to 134 | 4.86 0.09 to 466 | 4.59 0.10 to 413 | 3.85 0.16 to 107 | 3.36 0.03 to 400 | 3.20 0.04 to 329 | 3.06 0.42 to 29.68 | 3.03 0.03 to 432 | 2.94 0.03 to 380 | 2.96 0.32 to 30.98 | 2.91 0.43 to 22.45 | 2.91 0.03 to 363 | 2.83 0.03 to 397 | 2.87 0.03 to 358 | 2.74 0.03 to 336 | 2.74 0.03 to 399 | 2.48 0.39 to 19.18 | 2.33 0.15 to 42.28 | 2.25 0.14 to 44.52 | 2.27 0.15 to 41.36 | 2.10 0.15 to 40.01 | 1.86 0.29 to 14.08 | 1.82 0.29 to 13.83 | 1.49 0.42 to 5.40 | 1.43 0.24 to 9.40 | 1.42 0.24 to 9.43 | 1.17 0.18 to 7.22 | 1.16 0.18 to 7.29 | 1.07 0.06 to 26.05 | 1.08 0.05 to 28.30 | 1.02 0.10 to 9.25 | ALENIG_PO_120MG_QD | 0.96 0.24 to 4.33 | 0.84 0.15 to 5.32 | 0.83 0.24 to 2.79 | 0.80 0.14 to 4.67 | 0.79 0.09 to 6.28 | 0.70 0.12 to 4.17 | 0.70 0.12 to 4.22 | 0.59 0.11 to 3.19 | 0.56 0.09 to 3.56 | 0.55 0.11 to 2.82 | 0.46 0.09 to 2.48 | 0.45 0.01 to 8.12 | 0.44 0.05 to 3.77 | 0.43 0.04 to 4.36 | 0.42 0.04 to 3.99 | 0.40 0.01 to 13.84 | 0.38 0.04 to 3.21 | 0.37 0.08 to 1.93 | 0.28 0.06 to 1.46 | 0.27 0.05 to 1.44 | 0.26 0.02 to 3.66 | 0.27 0.05 to 1.39 | 0.21 0.02 to 1.87 | 0.18 0.02 to 1.46 | 0.15 0.02 to 1.15 |
| SEMA_SC_2p4MG_QW | 2.01 1.15 to 3.41 | 7.99 0.31 to 449 | 5.32 0.27 to 115 | 4.96 0.11 to 405 | 4.71 0.12 to 369 | 3.97 0.20 to 89.01 | 3.45 0.04 to 348 | 3.34 0.05 to 299 | 3.07 0.71 to 20.41 | 3.05 0.04 to 382 | 2.96 0.04 to 355 | 3.02 0.47 to 23.10 | 2.97 0.63 to 15.09 | 2.93 0.04 to 313 | 2.88 0.04 to 379 | 2.85 0.04 to 322 | 2.88 0.03 to 311 | 2.85 0.04 to 365 | 2.57 0.61 to 12.67 | 2.35 0.20 to 33.91 | 2.30 0.20 to 34.70 | 2.24 0.20 to 34.91 | 2.12 0.20 to 33.06 | 1.88 0.52 to 8.96 | 1.84 0.50 to 8.74 | 1.53 0.32 to 7.02 | 1.46 0.41 to 5.87 | 1.47 0.40 to 5.97 | 1.24 0.28 to 4.26 | 1.20 0.30 to 4.62 | 1.10 0.07 to 21.60 | 1.08 0.07 to 22.09 | 1.05 0.15 to 6.94 | 1.04 0.23 to 4.25 | SEMA_SC_2p4MG_QW | 0.87 0.28 to 3.04 | 0.86 0.19 to 3.77 | 0.83 0.21 to 2.95 | 0.82 0.14 to 4.16 | 0.73 0.24 to 2.28 | 0.72 0.19 to 2.61 | 0.60 0.19 to 1.95 | 0.59 0.14 to 2.06 | 0.57 0.19 to 1.66 | 0.48 0.18 to 1.19 | 0.48 0.01 to 6.31 | 0.46 0.07 to 2.39 | 0.45 0.06 to 3.06 | 0.43 0.06 to 2.85 | 0.41 0.01 to 11.12 | 0.39 0.05 to 2.10 | 0.39 0.12 to 1.10 | 0.29 0.10 to 0.84 | 0.28 0.09 to 0.85 | 0.28 0.02 to 2.86 | 0.28 0.09 to 0.78 | 0.22 0.03 to 1.31 | 0.19 0.03 to 0.94 | 0.16 0.02 to 0.77 |
| BIMASEMA_SC_1p0-10MG_QW | 2.28 0.65 to 7.36 | 9.14 0.29 to 649 | 5.87 0.25 to 158 | 5.76 0.10 to 514 | 5.29 0.12 to 492 | 4.52 0.18 to 118 | 4.03 0.05 to 409 | 3.83 0.05 to 400 | 3.54 0.71 to 23.92 | 3.49 0.04 to 463 | 3.47 0.04 to 498 | 3.49 0.41 to 33.03 | 3.41 0.51 to 22.81 | 3.31 0.04 to 366 | 3.29 0.03 to 471 | 3.26 0.04 to 401 | 3.33 0.03 to 405 | 3.24 0.03 to 455 | 2.93 0.48 to 19.44 | 2.68 0.19 to 47.82 | 2.55 0.17 to 47.44 | 2.60 0.18 to 49.71 | 2.42 0.18 to 42.83 | 2.16 0.50 to 11.38 | 2.09 0.51 to 10.64 | 1.74 0.25 to 11.06 | 1.66 0.33 to 9.60 | 1.68 0.33 to 9.33 | 1.38 0.23 to 7.37 | 1.36 0.23 to 7.81 | 1.28 0.06 to 27.07 | 1.23 0.07 to 26.33 | 1.18 0.13 to 10.13 | 1.19 0.19 to 6.79 | 1.15 0.33 to 3.52 | BIMASEMA_SC_1p0-10MG_QW | 0.97 0.15 to 5.87 | 0.92 0.17 to 4.97 | 0.93 0.11 to 6.72 | 0.83 0.24 to 2.80 | 0.82 0.14 to 4.36 | 0.69 0.15 to 3.22 | 0.67 0.11 to 3.47 | 0.66 0.14 to 2.84 | 0.55 0.17 to 1.50 | 0.52 0.01 to 8.94 | 0.53 0.06 to 3.88 | 0.51 0.05 to 4.69 | 0.49 0.05 to 4.16 | 0.47 0.01 to 15.64 | 0.45 0.05 to 3.21 | 0.44 0.09 to 1.96 | 0.33 0.07 to 1.48 | 0.32 0.07 to 1.43 | 0.31 0.02 to 3.96 | 0.32 0.07 to 1.40 | 0.25 0.03 to 2.09 | 0.22 0.02 to 1.49 | 0.18 0.02 to 1.22 |
| ALENIG_PO_45MG_QD | 2.32 0.60 to 9.36 | 9.60 0.28 to 631 | 6.24 0.24 to 162 | 5.84 0.10 to 586 | 5.64 0.12 to 499 | 4.69 0.19 to 123 | 4.14 0.04 to 481 | 3.86 0.05 to 426 | 3.67 0.48 to 35.83 | 3.56 0.04 to 513 | 3.52 0.04 to 450 | 3.57 0.38 to 38.43 | 3.50 0.49 to 28.02 | 3.46 0.03 to 439 | 3.34 0.04 to 504 | 3.49 0.04 to 457 | 3.31 0.03 to 410 | 3.36 0.03 to 503 | 2.98 0.47 to 22.27 | 2.77 0.18 to 52.04 | 2.67 0.17 to 54.97 | 2.70 0.16 to 53.18 | 2.47 0.16 to 50.70 | 2.27 0.34 to 16.96 | 2.21 0.33 to 16.48 | 1.78 0.48 to 6.90 | 1.72 0.29 to 11.62 | 1.70 0.29 to 11.52 | 1.44 0.21 to 8.82 | 1.40 0.22 to 9.25 | 1.28 0.07 to 29.76 | 1.28 0.06 to 32.97 | 1.23 0.12 to 11.70 | 1.20 0.36 to 4.14 | 1.17 0.26 to 5.31 | 1.04 0.17 to 6.53 | ALENIG_PO_45MG_QD | 0.95 0.15 to 6.02 | 0.95 0.11 to 7.82 | 0.86 0.14 to 5.00 | 0.84 0.14 to 5.19 | 0.71 0.13 to 4.08 | 0.69 0.11 to 4.28 | 0.67 0.13 to 3.59 | 0.56 0.10 to 3.02 | 0.54 0.01 to 10.64 | 0.54 0.06 to 4.66 | 0.52 0.04 to 5.28 | 0.50 0.04 to 5.02 | 0.48 0.01 to 15.50 | 0.46 0.04 to 3.85 | 0.45 0.09 to 2.37 | 0.34 0.07 to 1.78 | 0.33 0.06 to 1.81 | 0.32 0.02 to 4.41 | 0.32 0.06 to 1.75 | 0.25 0.03 to 2.38 | 0.22 0.02 to 1.79 | 0.18 0.02 to 1.41 |
| EFPE_SC_8MG_Q2W | 2.41 0.78 to 8.18 | 9.95 0.33 to 671 | 6.53 0.28 to 173 | 6.11 0.13 to 559 | 5.75 0.12 to 562 | 4.87 0.20 to 130 | 4.28 0.05 to 486 | 3.99 0.05 to 438 | 3.82 0.57 to 33.56 | 3.88 0.04 to 499 | 3.75 0.04 to 452 | 3.66 0.44 to 36.56 | 3.57 1.03 to 15.87 | 3.59 0.04 to 395 | 3.57 0.04 to 477 | 3.61 0.04 to 430 | 3.55 0.04 to 408 | 3.43 0.04 to 473 | 3.13 0.56 to 22.06 | 2.91 0.19 to 55.02 | 2.73 0.20 to 48.70 | 2.74 0.19 to 51.01 | 2.59 0.20 to 48.38 | 2.33 0.41 to 16.48 | 2.31 0.38 to 16.01 | 1.84 0.29 to 12.59 | 1.83 0.36 to 10.36 | 1.78 0.34 to 10.36 | 1.48 0.25 to 8.26 | 1.46 0.48 to 4.49 | 1.37 0.07 to 30.42 | 1.35 0.07 to 32.00 | 1.27 0.14 to 11.07 | 1.25 0.21 to 7.31 | 1.21 0.34 to 4.68 | 1.08 0.20 to 5.82 | 1.06 0.17 to 6.46 | EFPE_SC_8MG_Q2W | 1.02 0.13 to 6.74 | 0.88 0.17 to 4.88 | 0.88 0.33 to 2.37 | 0.73 0.16 to 3.57 | 0.71 0.12 to 3.93 | 0.69 0.16 to 3.18 | 0.58 0.13 to 2.73 | 0.56 0.01 to 9.58 | 0.57 0.07 to 3.93 | 0.55 0.05 to 4.90 | 0.53 0.05 to 4.52 | 0.49 0.01 to 16.46 | 0.48 0.05 to 3.61 | 0.47 0.11 to 2.19 | 0.36 0.08 to 1.57 | 0.35 0.08 to 1.60 | 0.34 0.02 to 4.24 | 0.34 0.08 to 1.56 | 0.27 0.03 to 2.11 | 0.23 0.02 to 1.61 | 0.19 0.02 to 1.28 |
| TERN60_PO_500MG_QD | 2.43 0.52 to 13.87 | 9.85 0.29 to 806 | 6.63 0.23 to 208 | 6.29 0.10 to 663 | 5.98 0.10 to 579 | 5.00 0.17 to 159 | 4.17 0.05 to 552 | 4.07 0.05 to 510 | 3.84 0.45 to 49.56 | 3.90 0.04 to 556 | 3.66 0.04 to 576 | 3.72 0.36 to 51.27 | 3.72 0.43 to 35.35 | 3.63 0.04 to 526 | 3.64 0.03 to 671 | 3.71 0.03 to 530 | 3.59 0.03 to 546 | 3.42 0.03 to 630 | 3.10 0.41 to 30.60 | 2.94 0.16 to 67.99 | 2.81 0.16 to 64.55 | 2.80 0.17 to 65.20 | 2.64 0.15 to 62.27 | 2.33 0.31 to 24.40 | 2.32 0.29 to 22.70 | 1.85 0.22 to 17.51 | 1.82 0.26 to 15.87 | 1.78 0.25 to 15.06 | 1.48 0.20 to 11.87 | 1.47 0.20 to 11.08 | 1.36 0.06 to 37.46 | 1.34 0.06 to 37.20 | 1.25 0.31 to 6.55 | 1.27 0.16 to 10.62 | 1.21 0.24 to 7.40 | 1.07 0.15 to 9.06 | 1.05 0.13 to 9.25 | 0.98 0.15 to 7.41 | TERN60_PO_500MG_QD | 0.89 0.14 to 7.20 | 0.88 0.13 to 6.50 | 0.75 0.12 to 5.53 | 0.71 0.10 to 5.70 | 0.70 0.12 to 4.73 | 0.58 0.09 to 4.11 | 0.56 0.01 to 12.51 | 0.56 0.16 to 1.99 | 0.55 0.04 to 6.88 | 0.53 0.04 to 6.34 | 0.49 0.01 to 22.36 | 0.49 0.04 to 5.12 | 0.47 0.08 to 3.25 | 0.35 0.06 to 2.45 | 0.35 0.06 to 2.47 | 0.34 0.02 to 5.58 | 0.34 0.06 to 2.35 | 0.27 0.02 to 2.97 | 0.23 0.02 to 2.33 | 0.19 0.02 to 1.86 |
| BIMASEMA_SC_1p0-30MG_QW | 2.73 0.85 to 8.26 | 11.12 0.37 to 702 | 7.16 0.30 to 179 | 6.80 0.14 to 589 | 6.36 0.16 to 558 | 5.48 0.24 to 135 | 4.66 0.06 to 526 | 4.55 0.06 to 444 | 4.21 0.91 to 29.08 | 4.29 0.05 to 545 | 4.07 0.04 to 546 | 4.15 0.50 to 38.24 | 4.07 0.62 to 27.51 | 4.04 0.05 to 464 | 3.96 0.04 to 540 | 4.07 0.04 to 486 | 3.88 0.04 to 510 | 3.87 0.04 to 525 | 3.54 0.61 to 22.63 | 3.16 0.23 to 56.68 | 3.10 0.22 to 57.19 | 3.06 0.23 to 58.05 | 2.95 0.23 to 50.72 | 2.58 0.65 to 12.74 | 2.52 0.65 to 12.55 | 2.05 0.33 to 12.86 | 2.02 0.41 to 10.84 | 2.02 0.39 to 10.61 | 1.67 0.28 to 8.50 | 1.64 0.29 to 8.83 | 1.50 0.08 to 32.61 | 1.47 0.08 to 33.47 | 1.45 0.15 to 11.82 | 1.42 0.24 to 8.03 | 1.37 0.44 to 4.11 | 1.21 0.36 to 4.12 | 1.16 0.20 to 6.96 | 1.13 0.20 to 5.78 | 1.13 0.14 to 7.39 | BIMASEMA_SC_1p0-30MG_QW | 0.99 0.18 to 4.96 | 0.83 0.18 to 3.85 | 0.81 0.14 to 3.94 | 0.78 0.18 to 3.28 | 0.65 0.22 to 1.74 | 0.63 0.02 to 9.87 | 0.63 0.07 to 4.46 | 0.61 0.06 to 5.15 | 0.58 0.06 to 4.96 | 0.55 0.01 to 16.81 | 0.54 0.06 to 3.80 | 0.53 0.11 to 2.28 | 0.40 0.09 to 1.64 | 0.39 0.09 to 1.68 | 0.37 0.02 to 4.66 | 0.38 0.09 to 1.55 | 0.30 0.03 to 2.30 | 0.26 0.03 to 1.74 | 0.21 0.02 to 1.37 |
| EFPE_SC_6MG_QW | 2.75 0.88 to 9.51 | 11.24 0.38 to 756 | 7.34 0.33 to 178 | 7.05 0.14 to 661 | 6.48 0.15 to 599 | 5.63 0.24 to 143 | 4.82 0.05 to 560 | 4.61 0.06 to 478 | 4.40 0.67 to 39.80 | 4.41 0.05 to 583 | 4.23 0.05 to 517 | 4.24 0.48 to 39.52 | 4.05 1.16 to 18.08 | 4.20 0.04 to 461 | 4.00 0.04 to 574 | 4.08 0.04 to 475 | 4.03 0.04 to 479 | 3.94 0.04 to 510 | 3.61 0.61 to 23.57 | 3.29 0.23 to 55.90 | 3.10 0.23 to 59.70 | 3.15 0.22 to 58.43 | 2.91 0.23 to 57.83 | 2.66 0.46 to 18.08 | 2.58 0.45 to 17.90 | 2.11 0.34 to 13.69 | 2.06 0.39 to 11.70 | 2.05 0.40 to 11.35 | 1.70 0.29 to 9.04 | 1.65 0.57 to 5.03 | 1.51 0.08 to 35.55 | 1.51 0.09 to 34.27 | 1.44 0.17 to 12.70 | 1.44 0.24 to 8.64 | 1.38 0.38 to 5.21 | 1.22 0.23 to 6.99 | 1.18 0.19 to 6.99 | 1.13 0.42 to 3.07 | 1.13 0.15 to 7.96 | 1.01 0.20 to 5.56 | EFPE_SC_6MG_QW | 0.84 0.18 to 4.00 | 0.82 0.14 to 4.36 | 0.80 0.18 to 3.49 | 0.66 0.14 to 3.08 | 0.64 0.02 to 10.30 | 0.64 0.08 to 4.62 | 0.63 0.06 to 5.17 | 0.60 0.06 to 4.98 | 0.56 0.02 to 18.69 | 0.55 0.06 to 4.18 | 0.53 0.12 to 2.39 | 0.41 0.09 to 1.81 | 0.39 0.09 to 1.73 | 0.38 0.03 to 4.84 | 0.38 0.09 to 1.68 | 0.30 0.03 to 2.45 | 0.26 0.03 to 1.90 | 0.21 0.02 to 1.50 |
| LOTI_PO_40MG_QD | 3.33 1.15 to 9.16 | 13.20 0.49 to 876 | 8.62 0.38 to 214 | 7.92 0.17 to 714 | 7.66 0.17 to 641 | 6.62 0.29 to 164 | 5.61 0.07 to 605 | 5.42 0.07 to 530 | 5.15 0.85 to 42.20 | 5.07 0.05 to 655 | 4.87 0.06 to 618 | 4.96 0.61 to 46.50 | 4.90 0.81 to 31.47 | 4.88 0.06 to 574 | 4.82 0.05 to 696 | 4.91 0.06 to 579 | 4.58 0.06 to 544 | 4.66 0.05 to 677 | 4.14 1.15 to 19.76 | 3.89 0.29 to 67.69 | 3.75 0.27 to 65.30 | 3.72 0.26 to 67.84 | 3.43 0.30 to 61.93 | 3.19 0.59 to 19.25 | 3.10 0.58 to 18.39 | 2.51 0.42 to 14.89 | 2.42 0.77 to 8.51 | 2.40 0.78 to 8.25 | 2.00 0.37 to 9.54 | 1.97 0.39 to 9.83 | 1.82 0.11 to 38.94 | 1.78 0.10 to 40.32 | 1.71 0.21 to 13.49 | 1.70 0.31 to 9.00 | 1.65 0.51 to 5.15 | 1.46 0.31 to 6.80 | 1.40 0.25 to 7.59 | 1.37 0.28 to 6.26 | 1.34 0.18 to 8.22 | 1.21 0.26 to 5.41 | 1.19 0.25 to 5.64 | LOTI_PO_40MG_QD | 0.97 0.18 to 4.58 | 0.94 0.39 to 2.26 | 0.79 0.19 to 3.12 | 0.76 0.02 to 12.18 | 0.76 0.10 to 5.07 | 0.74 0.08 to 5.83 | 0.70 0.08 to 5.49 | 0.67 0.02 to 21.00 | 0.65 0.07 to 4.26 | 0.65 0.15 to 2.48 | 0.48 0.20 to 1.06 | 0.47 0.19 to 1.16 | 0.46 0.03 to 5.36 | 0.45 0.19 to 1.04 | 0.36 0.04 to 2.65 | 0.31 0.04 to 1.95 | 0.25 0.03 to 1.56 |
| LIRA_SC_3p0MG_QD | 3.39 1.08 to 13.07 | 14.14 0.44 to 938 | 9.17 0.37 to 244 | 8.69 0.17 to 772 | 8.17 0.18 to 724 | 6.88 0.27 to 186 | 5.93 0.07 to 752 | 5.77 0.07 to 590 | 5.40 0.80 to 49.11 | 5.30 0.06 to 742 | 5.17 0.06 to 720 | 5.22 0.61 to 54.50 | 5.08 0.81 to 39.62 | 5.08 0.06 to 694 | 5.06 0.05 to 676 | 5.24 0.05 to 648 | 4.80 0.05 to 686 | 4.90 0.05 to 686 | 4.36 0.75 to 32.81 | 4.09 0.27 to 75.41 | 3.98 0.26 to 72.88 | 3.88 0.28 to 78.94 | 3.64 0.28 to 69.76 | 3.24 0.57 to 25.09 | 3.21 0.54 to 23.53 | 2.63 0.38 to 18.82 | 2.50 0.48 to 15.96 | 2.49 0.48 to 15.52 | 2.10 0.78 to 5.19 | 2.03 0.38 to 12.98 | 1.89 0.10 to 40.70 | 1.87 0.10 to 47.65 | 1.79 0.19 to 17.09 | 1.78 0.28 to 11.23 | 1.69 0.49 to 7.17 | 1.49 0.29 to 8.85 | 1.46 0.23 to 9.51 | 1.41 0.25 to 8.35 | 1.41 0.18 to 10.33 | 1.24 0.25 to 7.34 | 1.22 0.23 to 7.20 | 1.03 0.22 to 5.49 | LIRA_SC_3p0MG_QD | 0.97 0.21 to 4.96 | 0.81 0.18 to 4.09 | 0.79 0.02 to 14.00 | 0.78 0.10 to 6.25 | 0.77 0.08 to 7.80 | 0.75 0.07 to 7.40 | 0.71 0.02 to 23.64 | 0.68 0.07 to 5.45 | 0.65 0.15 to 3.36 | 0.49 0.11 to 2.59 | 0.48 0.11 to 2.45 | 0.47 0.03 to 6.36 | 0.46 0.10 to 2.47 | 0.38 0.04 to 3.26 | 0.32 0.04 to 2.41 | 0.26 0.03 to 1.98 |
| LOTI_PO_80MG_QD | 3.47 1.37 to 8.99 | 13.89 0.50 to 870 | 9.28 0.45 to 231 | 8.59 0.19 to 774 | 8.29 0.20 to 693 | 7.12 0.32 to 175 | 6.11 0.07 to 651 | 5.85 0.08 to 575 | 5.53 0.95 to 44.52 | 5.49 0.06 to 680 | 5.32 0.06 to 671 | 5.38 0.69 to 48.75 | 5.25 0.96 to 32.93 | 5.10 0.06 to 576 | 5.11 0.06 to 732 | 5.15 0.06 to 614 | 4.95 0.05 to 582 | 4.95 0.06 to 681 | 4.39 1.37 to 19.48 | 4.18 0.32 to 69.12 | 3.93 0.30 to 65.11 | 3.91 0.30 to 67.88 | 3.71 0.33 to 64.58 | 3.34 0.67 to 19.85 | 3.26 0.67 to 19.41 | 2.69 0.48 to 14.71 | 2.56 0.93 to 8.51 | 2.55 0.91 to 8.32 | 2.15 0.40 to 9.34 | 2.09 0.45 to 9.76 | 1.94 0.12 to 39.54 | 1.89 0.11 to 40.73 | 1.84 0.23 to 14.10 | 1.80 0.35 to 8.89 | 1.74 0.60 to 5.34 | 1.52 0.35 to 7.05 | 1.50 0.28 to 7.67 | 1.45 0.31 to 6.17 | 1.43 0.21 to 8.63 | 1.29 0.30 to 5.48 | 1.26 0.29 to 5.57 | 1.06 0.44 to 2.58 | 1.03 0.20 to 4.73 | LOTI_PO_80MG_QD | 0.84 0.22 to 3.11 | 0.81 0.02 to 12.46 | 0.81 0.11 to 5.04 | 0.78 0.09 to 6.30 | 0.76 0.08 to 5.44 | 0.72 0.02 to 21.28 | 0.69 0.08 to 4.32 | 0.69 0.18 to 2.53 | 0.51 0.25 to 1.03 | 0.49 0.23 to 1.10 | 0.48 0.04 to 5.19 | 0.48 0.23 to 0.99 | 0.39 0.04 to 2.70 | 0.33 0.04 to 2.02 | 0.27 0.03 to 1.58 |
| OTHER_ACTIVE_bimagrumab | 4.18 1.60 to 11.20 | 17.06 0.58 to 1055 | 11.01 0.51 to 267 | 10.50 0.22 to 928 | 9.70 0.24 to 782 | 8.33 0.38 to 206 | 7.19 0.09 to 750 | 7.07 0.09 to 682 | 6.46 1.61 to 41.36 | 6.48 0.08 to 832 | 6.24 0.07 to 805 | 6.35 0.84 to 55.27 | 6.31 1.12 to 37.85 | 6.37 0.07 to 684 | 6.26 0.07 to 830 | 6.08 0.07 to 719 | 6.17 0.07 to 688 | 5.98 0.07 to 844 | 5.41 1.07 to 30.93 | 4.88 0.39 to 82.60 | 4.71 0.37 to 78.81 | 4.79 0.36 to 86.02 | 4.51 0.38 to 73.00 | 3.92 1.20 to 17.64 | 3.84 1.17 to 17.94 | 3.22 0.56 to 18.92 | 3.05 0.73 to 15.49 | 3.08 0.68 to 15.24 | 2.58 0.51 to 11.57 | 2.49 0.52 to 12.20 | 2.32 0.13 to 46.51 | 2.28 0.13 to 48.12 | 2.21 0.27 to 16.66 | 2.18 0.40 to 11.20 | 2.10 0.84 to 5.50 | 1.82 0.67 to 5.83 | 1.78 0.33 to 9.65 | 1.73 0.37 to 7.93 | 1.72 0.24 to 10.99 | 1.53 0.58 to 4.47 | 1.52 0.32 to 6.91 | 1.27 0.32 to 5.29 | 1.23 0.24 to 5.60 | 1.19 0.32 to 4.63 | OTHER_ACTIVE_bimagrumab | 0.97 0.03 to 14.26 | 0.97 0.13 to 6.38 | 0.95 0.11 to 7.49 | 0.91 0.10 to 6.97 | 0.86 0.02 to 25.85 | 0.84 0.10 to 5.00 | 0.82 0.20 to 3.12 | 0.61 0.17 to 2.37 | 0.59 0.16 to 2.28 | 0.58 0.04 to 6.83 | 0.58 0.16 to 2.17 | 0.47 0.06 to 3.23 | 0.40 0.05 to 2.29 | 0.33 0.04 to 1.87 |
| MAZD_SC_16MG_QW | 4.29 0.34 to 137 | 18.70 0.28 to 3507 | 12.02 0.22 to 1085 | 12.11 0.12 to 2660 | 11.42 0.11 to 2584 | 9.14 0.16 to 912 | 7.89 0.05 to 2249 | 7.95 0.05 to 2119 | 7.06 0.35 to 313 | 7.13 0.04 to 2359 | 7.16 0.04 to 2289 | 6.68 0.31 to 326 | 6.57 0.37 to 280 | 6.93 0.04 to 2192 | 6.89 0.04 to 2195 | 6.87 0.04 to 1890 | 6.65 0.04 to 1746 | 6.68 0.04 to 1966 | 5.74 0.30 to 235 | 5.27 0.15 to 376 | 5.18 0.14 to 377 | 5.12 0.14 to 389 | 4.87 0.15 to 386 | 4.36 0.23 to 170 | 4.19 0.22 to 153 | 3.39 0.17 to 139 | 3.23 0.20 to 136 | 3.26 0.18 to 124 | 2.61 0.15 to 94.60 | 2.59 0.15 to 99.65 | 2.48 0.06 to 198 | 2.45 0.06 to 209 | 2.32 0.10 to 109 | 2.22 0.12 to 85.12 | 2.09 0.16 to 72.78 | 1.92 0.11 to 68.65 | 1.85 0.09 to 72.47 | 1.77 0.10 to 70.39 | 1.79 0.08 to 69.50 | 1.59 0.10 to 60.57 | 1.57 0.10 to 60.19 | 1.32 0.08 to 48.67 | 1.26 0.07 to 44.80 | 1.24 0.08 to 46.05 | 1.03 0.07 to 35.81 | MAZD_SC_16MG_QW | 1.01 0.05 to 43.19 | 0.98 0.04 to 47.31 | 0.93 0.04 to 45.13 | 0.92 0.01 to 95.93 | 0.85 0.03 to 37.08 | 0.82 0.05 to 30.53 | 0.64 0.04 to 23.29 | 0.62 0.04 to 22.04 | 0.60 0.02 to 37.69 | 0.59 0.04 to 21.54 | 0.48 0.02 to 22.33 | 0.41 0.02 to 16.83 | 0.33 0.01 to 14.07 |
| TERN60_PO_750MG_QD | 4.30 0.90 to 25.30 | 17.31 0.51 to 1404 | 11.81 0.43 to 366 | 11.00 0.18 to 1146 | 10.38 0.18 to 1029 | 8.92 0.31 to 285 | 7.44 0.08 to 931 | 7.44 0.07 to 899 | 6.84 0.75 to 89.74 | 6.77 0.07 to 1025 | 6.85 0.06 to 962 | 6.64 0.64 to 90.74 | 6.50 0.75 to 63.76 | 6.51 0.06 to 978 | 6.46 0.05 to 1103 | 6.35 0.06 to 950 | 6.26 0.06 to 872 | 6.25 0.06 to 1014 | 5.54 0.71 to 55.99 | 5.20 0.28 to 123 | 4.99 0.28 to 116 | 4.98 0.30 to 115 | 4.68 0.29 to 117 | 4.16 0.51 to 44.09 | 4.08 0.51 to 41.43 | 3.30 0.38 to 32.74 | 3.25 0.45 to 27.18 | 3.19 0.45 to 27.13 | 2.62 0.33 to 21.55 | 2.57 0.35 to 21.09 | 2.38 0.12 to 65.67 | 2.33 0.11 to 72.09 | 2.22 0.52 to 11.47 | 2.26 0.27 to 19.39 | 2.16 0.42 to 13.36 | 1.89 0.26 to 16.56 | 1.85 0.21 to 17.01 | 1.76 0.25 to 14.15 | 1.78 0.50 to 6.07 | 1.58 0.22 to 13.45 | 1.55 0.22 to 12.01 | 1.32 0.20 to 10.21 | 1.28 0.16 to 10.40 | 1.23 0.20 to 9.10 | 1.03 0.16 to 7.82 | 0.99 0.02 to 21.43 | TERN60_PO_750MG_QD | 0.98 0.08 to 12.05 | 0.94 0.08 to 11.22 | 0.85 0.02 to 41.06 | 0.84 0.07 to 9.43 | 0.85 0.12 to 5.97 | 0.63 0.10 to 4.65 | 0.61 0.09 to 4.62 | 0.61 0.03 to 10.07 | 0.59 0.10 to 4.39 | 0.48 0.04 to 5.15 | 0.41 0.03 to 4.28 | 0.33 0.03 to 3.49 |
| VK2735_SC_10MG_QW | 4.43 0.71 to 31.52 | 19.28 0.47 to 1563 | 11.65 0.38 to 474 | 11.15 0.16 to 1278 | 11.08 0.18 to 1092 | 8.69 0.28 to 380 | 7.62 0.07 to 1065 | 7.38 0.07 to 1073 | 7.12 0.66 to 100 | 7.23 0.06 to 1155 | 6.82 0.06 to 1090 | 6.85 0.51 to 108 | 6.65 0.67 to 86.75 | 6.44 0.05 to 1115 | 6.39 0.05 to 1130 | 6.64 0.06 to 934 | 6.52 0.06 to 1002 | 6.43 0.06 to 1105 | 5.82 0.60 to 73.50 | 5.42 0.27 to 132 | 5.23 0.26 to 131 | 5.09 0.26 to 142 | 4.57 0.60 to 73.75 | 4.29 0.45 to 51.00 | 4.21 0.44 to 48.13 | 3.46 0.32 to 38.95 | 3.30 0.37 to 34.77 | 3.27 0.37 to 34.87 | 2.74 0.28 to 27.61 | 2.66 0.31 to 27.27 | 2.47 0.10 to 77.42 | 2.43 0.10 to 76.45 | 2.36 0.16 to 34.27 | 2.35 0.23 to 25.23 | 2.23 0.33 to 17.40 | 1.98 0.21 to 20.06 | 1.92 0.19 to 22.52 | 1.82 0.20 to 18.48 | 1.80 0.15 to 23.32 | 1.63 0.19 to 15.72 | 1.59 0.19 to 15.98 | 1.36 0.17 to 12.77 | 1.30 0.13 to 13.31 | 1.28 0.16 to 11.57 | 1.05 0.13 to 9.41 | 1.02 0.02 to 26.48 | 1.02 0.08 to 12.55 | VK2735_SC_10MG_QW | 0.96 0.20 to 4.50 | 0.91 0.02 to 39.74 | 0.87 0.06 to 11.40 | 0.86 0.11 to 7.62 | 0.65 0.08 to 5.75 | 0.62 0.08 to 5.76 | 0.62 0.03 to 12.20 | 0.61 0.08 to 5.49 | 0.49 0.11 to 1.91 | 0.42 0.03 to 5.29 | 0.34 0.03 to 4.22 |
| VK2735_SC_5p0MG_QW | 4.62 0.79 to 34.07 | 19.55 0.46 to 1632 | 12.11 0.41 to 489 | 11.81 0.18 to 1323 | 11.55 0.18 to 1096 | 9.02 0.31 to 358 | 7.95 0.08 to 1137 | 7.72 0.08 to 974 | 7.31 0.73 to 105 | 7.19 0.06 to 1200 | 7.02 0.06 to 1104 | 7.11 0.57 to 110 | 6.85 0.69 to 84.43 | 6.97 0.06 to 1191 | 6.60 0.06 to 1199 | 6.82 0.06 to 1069 | 6.77 0.06 to 939 | 6.66 0.06 to 1148 | 6.00 0.64 to 72.49 | 5.53 0.27 to 140 | 5.37 0.28 to 141 | 5.35 0.27 to 143 | 4.82 0.59 to 77.79 | 4.42 0.48 to 53.91 | 4.34 0.46 to 51.46 | 3.58 0.35 to 40.39 | 3.48 0.41 to 34.35 | 3.40 0.40 to 36.47 | 2.77 0.29 to 28.86 | 2.78 0.31 to 27.63 | 2.57 0.10 to 82.40 | 2.50 0.10 to 78.90 | 2.44 0.18 to 38.12 | 2.38 0.25 to 24.56 | 2.31 0.35 to 18.09 | 2.03 0.24 to 20.37 | 2.01 0.20 to 22.24 | 1.89 0.22 to 18.62 | 1.88 0.16 to 23.86 | 1.71 0.20 to 16.48 | 1.66 0.20 to 16.84 | 1.42 0.18 to 12.79 | 1.33 0.14 to 13.91 | 1.32 0.18 to 11.78 | 1.09 0.14 to 9.81 | 1.07 0.02 to 26.66 | 1.06 0.09 to 12.87 | 1.05 0.22 to 4.98 | VK2735_SC_5p0MG_QW | 0.96 0.02 to 45.78 | 0.89 0.07 to 11.27 | 0.89 0.12 to 7.76 | 0.67 0.09 to 5.89 | 0.66 0.09 to 5.95 | 0.63 0.03 to 11.97 | 0.64 0.09 to 5.62 | 0.52 0.12 to 1.98 | 0.43 0.03 to 5.37 | 0.35 0.03 to 4.41 |
| MAZD_SC_4p5MG_QW | 4.90 0.18 to 151 | 21.12 0.18 to 3992 | 13.10 0.15 to 1181 | 11.84 0.15 to 2207 | 11.23 0.16 to 2333 | 9.91 0.11 to 941 | 8.58 0.04 to 2547 | 8.30 0.04 to 2355 | 7.88 0.22 to 376 | 7.62 0.03 to 2950 | 7.48 0.03 to 2265 | 7.63 0.18 to 371 | 7.31 0.21 to 310 | 7.42 0.03 to 2536 | 7.50 0.03 to 2720 | 7.45 0.03 to 2546 | 7.30 0.03 to 2378 | 7.07 0.03 to 2434 | 6.32 0.19 to 267 | 6.03 0.10 to 466 | 5.76 0.10 to 430 | 5.65 0.09 to 460 | 5.54 0.10 to 373 | 4.77 0.14 to 205 | 4.67 0.13 to 190 | 3.72 0.10 to 154 | 3.72 0.11 to 133 | 3.60 0.11 to 131 | 3.02 0.09 to 107 | 2.98 0.09 to 114 | 2.73 0.04 to 245 | 2.72 0.04 to 228 | 2.67 0.05 to 126 | 2.49 0.07 to 99.69 | 2.44 0.09 to 80.22 | 2.12 0.06 to 82.99 | 2.07 0.06 to 86.71 | 2.03 0.06 to 72.66 | 2.02 0.04 to 93.40 | 1.81 0.06 to 67.75 | 1.77 0.05 to 62.79 | 1.49 0.05 to 51.03 | 1.41 0.04 to 51.42 | 1.39 0.05 to 46.77 | 1.16 0.04 to 41.85 | 1.09 0.01 to 81.45 | 1.18 0.02 to 49.51 | 1.10 0.03 to 54.97 | 1.04 0.02 to 50.89 | MAZD_SC_4p5MG_QW | 0.94 0.02 to 43.08 | 0.94 0.03 to 34.56 | 0.71 0.02 to 24.25 | 0.68 0.02 to 24.22 | 0.66 0.01 to 41.91 | 0.68 0.02 to 24.05 | 0.53 0.01 to 22.49 | 0.45 0.01 to 19.76 | 0.37 0.01 to 16.55 |
| DANU_PO_80MG_BID | 4.98 1.02 to 36.09 | 21.52 0.57 to 1782 | 14.06 0.45 to 484 | 12.75 0.19 to 1525 | 12.19 0.22 to 1376 | 10.55 0.36 to 354 | 8.85 0.09 to 1275 | 8.75 0.10 to 1100 | 8.11 0.89 to 111 | 8.18 0.08 to 1324 | 8.16 0.07 to 1222 | 7.93 0.68 to 103 | 7.74 0.83 to 87.74 | 7.58 0.07 to 1141 | 7.72 0.07 to 1284 | 7.52 0.07 to 1203 | 7.45 0.07 to 1043 | 7.46 0.07 to 1178 | 6.54 0.85 to 76.53 | 6.29 0.34 to 143 | 5.96 0.31 to 139 | 5.81 0.34 to 144 | 5.56 0.34 to 149 | 4.92 0.61 to 57.98 | 4.76 0.60 to 50.92 | 3.83 0.45 to 42.25 | 3.74 0.53 to 36.81 | 3.75 0.52 to 37.69 | 3.05 0.38 to 30.19 | 3.05 0.41 to 29.39 | 2.87 0.12 to 90.79 | 2.80 0.12 to 84.20 | 2.67 0.22 to 36.53 | 2.64 0.31 to 26.15 | 2.53 0.48 to 18.64 | 2.22 0.31 to 21.95 | 2.18 0.26 to 22.69 | 2.07 0.28 to 19.08 | 2.06 0.20 to 23.88 | 1.84 0.26 to 17.92 | 1.83 0.24 to 17.33 | 1.54 0.23 to 13.68 | 1.48 0.18 to 14.48 | 1.44 0.23 to 12.30 | 1.19 0.20 to 10.38 | 1.18 0.03 to 29.98 | 1.18 0.11 to 14.59 | 1.15 0.09 to 15.77 | 1.13 0.09 to 14.68 | 1.06 0.02 to 45.12 | DANU_PO_80MG_BID | 0.98 0.15 to 8.25 | 0.74 0.12 to 6.35 | 0.71 0.11 to 6.01 | 0.70 0.04 to 12.88 | 0.70 0.11 to 6.01 | 0.56 0.05 to 7.25 | 0.48 0.18 to 1.24 | 0.39 0.15 to 0.99 |
| TIRZ_SC_MTD_QW | 5.13 2.10 to 13.78 | 20.91 0.72 to 1274 | 13.72 0.61 to 323 | 12.91 0.28 to 1128 | 12.27 0.29 to 1000 | 10.37 0.47 to 242 | 9.00 0.11 to 1041 | 8.93 0.11 to 824 | 8.06 1.39 to 63.84 | 7.92 0.10 to 987 | 7.86 0.09 to 901 | 7.80 1.05 to 67.38 | 7.71 1.41 to 46.12 | 7.77 0.09 to 883 | 7.63 0.08 to 1070 | 7.57 0.09 to 903 | 7.38 0.09 to 848 | 7.20 0.08 to 1061 | 6.56 1.34 to 39.23 | 6.10 0.47 to 101 | 6.01 0.44 to 97.97 | 5.88 0.45 to 99.76 | 5.52 0.46 to 99.56 | 4.92 1.00 to 31.16 | 4.73 0.95 to 30.78 | 3.96 0.69 to 21.58 | 3.78 0.85 to 18.97 | 3.80 0.86 to 19.32 | 3.15 0.62 to 14.44 | 3.09 0.66 to 14.95 | 2.87 0.17 to 57.57 | 2.81 0.16 to 63.67 | 2.71 0.36 to 20.69 | 2.72 0.52 to 13.24 | 2.56 0.91 to 8.04 | 2.26 0.51 to 11.44 | 2.20 0.42 to 11.27 | 2.11 0.46 to 9.51 | 2.13 0.31 to 13.31 | 1.87 0.44 to 8.90 | 1.87 0.42 to 8.51 | 1.53 0.40 to 6.50 | 1.53 0.30 to 6.89 | 1.46 0.40 to 5.66 | 1.22 0.32 to 5.06 | 1.22 0.03 to 18.72 | 1.17 0.17 to 8.00 | 1.16 0.13 to 9.01 | 1.13 0.13 to 8.56 | 1.06 0.03 to 32.65 | 1.02 0.12 to 6.68 | TIRZ_SC_MTD_QW | 0.75 0.21 to 2.96 | 0.73 0.20 to 2.88 | 0.73 0.05 to 8.36 | 0.70 0.20 to 2.80 | 0.57 0.07 to 4.19 | 0.49 0.06 to 3.19 | 0.40 0.05 to 2.57 |
| LOTI_PO_260MG_QD | 6.83 2.72 to 17.00 | 27.20 1.01 to 1723 | 18.20 0.86 to 452 | 16.69 0.34 to 1594 | 16.03 0.38 to 1287 | 13.82 0.64 to 333 | 12.00 0.15 to 1268 | 11.53 0.16 to 1113 | 10.56 1.87 to 86.28 | 10.68 0.12 to 1397 | 10.31 0.12 to 1253 | 10.55 1.34 to 91.48 | 10.32 1.84 to 61.31 | 9.99 0.11 to 1131 | 10.17 0.11 to 1355 | 9.89 0.12 to 1143 | 9.82 0.11 to 1108 | 9.81 0.11 to 1350 | 8.58 2.66 to 37.25 | 8.08 0.62 to 137 | 7.75 0.60 to 131 | 7.80 0.58 to 131 | 7.27 0.65 to 120 | 6.60 1.34 to 37.61 | 6.41 1.26 to 37.82 | 5.21 0.92 to 28.15 | 5.03 1.87 to 15.87 | 4.97 1.84 to 16.03 | 4.21 0.82 to 18.48 | 4.11 0.87 to 18.85 | 3.77 0.23 to 77.77 | 3.68 0.23 to 80.11 | 3.55 0.44 to 27.43 | 3.53 0.68 to 17.06 | 3.43 1.19 to 9.97 | 2.99 0.68 to 13.34 | 2.97 0.56 to 14.78 | 2.78 0.64 to 12.21 | 2.82 0.41 to 16.45 | 2.48 0.61 to 10.89 | 2.45 0.55 to 10.71 | 2.07 0.94 to 4.90 | 2.02 0.39 to 8.92 | 1.95 0.97 to 3.98 | 1.65 0.42 to 5.87 | 1.57 0.04 to 23.24 | 1.59 0.22 to 10.06 | 1.54 0.17 to 11.78 | 1.48 0.17 to 10.66 | 1.41 0.04 to 42.33 | 1.35 0.16 to 8.63 | 1.34 0.34 to 4.72 | LOTI_PO_260MG_QD | 0.96 0.46 to 2.09 | 0.94 0.07 to 10.68 | 0.94 0.49 to 1.86 | 0.76 0.09 to 5.00 | 0.65 0.08 to 3.73 | 0.53 0.06 to 3.11 |
| LOTI_PO_140MG_QD | 7.09 2.72 to 18.55 | 28.29 1.02 to 1829 | 18.76 0.86 to 468 | 17.19 0.36 to 1558 | 16.34 0.41 to 1371 | 14.43 0.65 to 346 | 12.51 0.15 to 1269 | 11.70 0.16 to 1118 | 11.13 1.92 to 87.98 | 10.86 0.12 to 1364 | 10.68 0.13 to 1338 | 10.77 1.35 to 92.88 | 10.62 1.89 to 64.96 | 10.50 0.12 to 1267 | 10.18 0.11 to 1449 | 10.22 0.12 to 1194 | 10.31 0.12 to 1286 | 9.88 0.12 to 1337 | 8.91 2.68 to 39.70 | 8.40 0.64 to 137 | 7.98 0.60 to 142 | 7.95 0.60 to 135 | 7.43 0.66 to 128 | 6.73 1.36 to 39.27 | 6.58 1.33 to 39.06 | 5.43 0.98 to 29.13 | 5.18 1.80 to 17.43 | 5.17 1.77 to 17.15 | 4.33 0.82 to 19.42 | 4.24 0.90 to 20.27 | 3.91 0.24 to 83.73 | 3.87 0.24 to 86.29 | 3.68 0.45 to 28.80 | 3.66 0.70 to 18.49 | 3.53 1.18 to 10.76 | 3.12 0.70 to 14.34 | 3.06 0.55 to 15.61 | 2.90 0.62 to 12.68 | 2.89 0.40 to 17.36 | 2.58 0.60 to 11.58 | 2.54 0.58 to 10.86 | 2.14 0.86 to 5.40 | 2.07 0.41 to 9.35 | 2.02 0.91 to 4.41 | 1.69 0.44 to 6.29 | 1.62 0.05 to 24.48 | 1.65 0.22 to 10.54 | 1.61 0.17 to 12.86 | 1.52 0.17 to 11.67 | 1.47 0.04 to 46.79 | 1.40 0.17 to 9.07 | 1.38 0.35 to 5.00 | 1.04 0.48 to 2.15 | LOTI_PO_140MG_QD | 0.96 0.07 to 11.36 | 0.97 0.45 to 2.05 | 0.78 0.09 to 5.24 | 0.68 0.08 to 4.08 | 0.55 0.07 to 3.19 |
| HRS7535_PO_180MG_QD | 7.24 0.76 to 82.67 | 27.69 1.12 to 2301 | 19.26 0.46 to 1012 | 18.97 0.24 to 2554 | 17.96 0.23 to 2212 | 14.52 0.35 to 790 | 12.69 0.09 to 2301 | 12.22 0.10 to 1960 | 11.68 0.79 to 231 | 11.28 0.08 to 2251 | 11.62 0.09 to 2283 | 10.98 0.65 to 233 | 10.98 0.74 to 187 | 10.92 0.07 to 2099 | 11.16 0.08 to 2215 | 10.78 0.08 to 2012 | 10.45 0.08 to 2092 | 10.60 0.08 to 1774 | 9.40 0.72 to 161 | 8.60 0.32 to 278 | 8.46 0.33 to 265 | 8.26 0.31 to 281 | 7.98 0.31 to 287 | 7.01 0.49 to 123 | 6.93 0.51 to 128 | 5.57 0.37 to 91.61 | 5.40 0.44 to 80.30 | 5.39 0.43 to 82.37 | 4.39 0.33 to 65.11 | 4.28 0.33 to 70.00 | 3.84 0.38 to 70.17 | 3.78 0.39 to 73.73 | 3.78 0.21 to 72.34 | 3.78 0.27 to 57.43 | 3.62 0.35 to 45.44 | 3.18 0.25 to 49.85 | 3.14 0.23 to 48.97 | 2.93 0.24 to 44.95 | 2.95 0.18 to 50.87 | 2.67 0.21 to 41.58 | 2.61 0.21 to 38.11 | 2.18 0.19 to 30.98 | 2.13 0.16 to 29.80 | 2.07 0.19 to 28.05 | 1.73 0.15 to 24.47 | 1.68 0.03 to 57.50 | 1.64 0.10 to 29.38 | 1.60 0.08 to 32.25 | 1.58 0.08 to 31.29 | 1.50 0.02 to 84.21 | 1.43 0.08 to 27.69 | 1.38 0.12 to 19.53 | 1.07 0.09 to 14.59 | 1.04 0.09 to 13.73 | HRS7535_PO_180MG_QD | 0.99 0.09 to 13.46 | 0.80 0.04 to 14.77 | 0.67 0.04 to 11.66 | 0.54 0.03 to 9.82 |
| LOTI_PO_200MG_QD | 7.29 2.86 to 18.04 | 29.02 1.04 to 1811 | 19.15 0.92 to 467 | 18.05 0.36 to 1577 | 17.00 0.40 to 1327 | 14.75 0.68 to 359 | 12.92 0.16 to 1305 | 12.30 0.16 to 1140 | 11.34 2.02 to 91.06 | 11.12 0.12 to 1506 | 10.90 0.13 to 1379 | 11.08 1.39 to 94.17 | 10.94 2.00 to 65.94 | 10.66 0.12 to 1240 | 10.49 0.12 to 1535 | 10.66 0.13 to 1264 | 10.33 0.12 to 1265 | 10.29 0.12 to 1378 | 9.05 2.88 to 38.95 | 8.60 0.67 to 142 | 8.21 0.64 to 141 | 8.23 0.60 to 140 | 7.72 0.68 to 130 | 6.96 1.43 to 40.06 | 6.80 1.35 to 39.29 | 5.54 0.97 to 29.16 | 5.30 2.01 to 17.11 | 5.29 1.95 to 17.20 | 4.49 0.86 to 19.30 | 4.36 0.94 to 20.07 | 3.93 0.25 to 83.27 | 4.00 0.24 to 84.46 | 3.81 0.47 to 28.63 | 3.74 0.72 to 18.64 | 3.63 1.28 to 10.61 | 3.17 0.72 to 14.21 | 3.11 0.57 to 16.13 | 2.98 0.64 to 12.69 | 2.98 0.43 to 17.39 | 2.66 0.64 to 11.30 | 2.61 0.59 to 11.21 | 2.20 0.97 to 5.28 | 2.16 0.40 to 9.63 | 2.07 1.01 to 4.26 | 1.74 0.46 to 6.22 | 1.70 0.05 to 25.23 | 1.71 0.23 to 10.28 | 1.64 0.18 to 12.42 | 1.57 0.18 to 11.47 | 1.48 0.04 to 45.63 | 1.43 0.17 to 9.02 | 1.42 0.36 to 5.05 | 1.07 0.54 to 2.03 | 1.03 0.49 to 2.20 | 1.01 0.07 to 10.92 | LOTI_PO_200MG_QD | 0.81 0.10 to 5.28 | 0.69 0.08 to 4.19 | 0.56 0.07 to 3.29 |
| VK2735_SC_15MG_QW | 9.02 1.68 to 61.86 | 37.93 1.02 to 3291 | 23.29 0.84 to 933 | 23.18 0.36 to 2488 | 22.43 0.38 to 2307 | 17.88 0.64 to 722 | 16.05 0.15 to 2197 | 15.22 0.15 to 1888 | 14.62 1.49 to 194 | 14.20 0.12 to 2286 | 14.09 0.12 to 2085 | 14.04 1.18 to 202 | 13.71 1.47 to 156 | 13.26 0.12 to 2085 | 13.50 0.12 to 2133 | 13.36 0.12 to 2049 | 13.41 0.12 to 2066 | 13.16 0.13 to 2167 | 11.71 1.37 to 135 | 10.93 0.56 to 250 | 10.60 0.57 to 264 | 10.47 0.55 to 262 | 9.14 1.42 to 136 | 8.77 0.97 to 97.49 | 8.49 0.95 to 95.42 | 6.97 0.74 to 76.14 | 6.78 0.87 to 63.83 | 6.70 0.85 to 65.67 | 5.48 0.65 to 53.43 | 5.53 0.67 to 50.28 | 5.16 0.22 to 156 | 4.97 0.21 to 152 | 4.75 0.38 to 67.38 | 4.68 0.54 to 46.79 | 4.52 0.76 to 32.45 | 3.99 0.48 to 39.70 | 3.95 0.42 to 39.48 | 3.66 0.47 to 36.48 | 3.76 0.34 to 41.23 | 3.34 0.43 to 29.01 | 3.30 0.41 to 30.67 | 2.77 0.38 to 23.63 | 2.64 0.31 to 25.74 | 2.59 0.37 to 22.30 | 2.13 0.31 to 17.75 | 2.10 0.04 to 49.23 | 2.09 0.19 to 24.89 | 2.03 0.52 to 8.90 | 1.94 0.50 to 8.54 | 1.89 0.04 to 75.33 | 1.78 0.14 to 20.83 | 1.76 0.24 to 14.32 | 1.32 0.20 to 11.26 | 1.28 0.19 to 10.62 | 1.25 0.07 to 24.00 | 1.23 0.19 to 10.46 | VK2735_SC_15MG_QW | 0.85 0.07 to 9.64 | 0.69 0.05 to 7.91 |
| DANU_PO_140MG_BID | 10.38 2.34 to 69.66 | 45.15 1.26 to 3433 | 28.96 1.01 to 962 | 26.96 0.44 to 3216 | 25.30 0.47 to 2848 | 22.22 0.77 to 729 | 18.21 0.18 to 2656 | 18.13 0.21 to 2375 | 17.12 2.01 to 228 | 16.96 0.17 to 2681 | 17.16 0.15 to 2620 | 16.38 1.46 to 214 | 15.75 1.88 to 178 | 16.05 0.15 to 2314 | 15.84 0.15 to 2641 | 15.69 0.15 to 2374 | 15.52 0.14 to 2165 | 15.15 0.14 to 2366 | 13.59 1.77 to 149 | 12.79 0.72 to 315 | 12.37 0.65 to 318 | 12.25 0.72 to 306 | 11.47 0.73 to 289 | 10.32 1.30 to 112 | 10.00 1.26 to 106 | 8.13 0.96 to 84.33 | 7.76 1.16 to 74.70 | 7.80 1.10 to 73.48 | 6.32 0.86 to 61.56 | 6.24 0.86 to 60.29 | 5.94 0.24 to 179 | 5.75 0.25 to 170 | 5.55 0.48 to 75.59 | 5.53 0.69 to 53.48 | 5.25 1.06 to 37.38 | 4.64 0.67 to 44.12 | 4.61 0.56 to 45.34 | 4.29 0.62 to 41.16 | 4.28 0.43 to 48.97 | 3.88 0.57 to 35.12 | 3.80 0.53 to 33.95 | 3.23 0.51 to 27.61 | 3.08 0.41 to 28.19 | 2.99 0.50 to 25.55 | 2.50 0.44 to 20.48 | 2.43 0.06 to 60.67 | 2.45 0.23 to 29.65 | 2.40 0.19 to 31.43 | 2.31 0.19 to 29.79 | 2.21 0.05 to 91.00 | 2.08 0.80 to 5.56 | 2.06 0.31 to 16.50 | 1.54 0.27 to 12.65 | 1.47 0.24 to 12.20 | 1.49 0.09 to 27.67 | 1.46 0.24 to 11.80 | 1.17 0.10 to 14.41 | DANU_PO_140MG_BID | 0.82 0.35 to 1.90 |
| DANU_PO_200MG_BID | 12.84 2.86 to 87.69 | 54.32 1.49 to 4008 | 35.25 1.26 to 1246 | 33.96 0.51 to 3718 | 31.87 0.59 to 3365 | 27.07 0.97 to 864 | 22.95 0.24 to 3319 | 22.67 0.27 to 2929 | 20.64 2.51 to 275 | 20.15 0.21 to 3205 | 20.73 0.19 to 3210 | 20.30 1.86 to 282 | 19.45 2.29 to 211 | 19.69 0.19 to 2728 | 19.45 0.19 to 3118 | 19.48 0.19 to 2812 | 18.94 0.18 to 2704 | 18.64 0.19 to 2811 | 16.98 2.18 to 185 | 15.75 0.88 to 382 | 15.12 0.80 to 354 | 15.29 0.87 to 347 | 14.15 0.90 to 355 | 12.64 1.68 to 140 | 12.35 1.60 to 134 | 9.89 1.21 to 98.24 | 9.67 1.46 to 89.25 | 9.52 1.40 to 90.53 | 7.76 1.05 to 78.34 | 7.83 1.10 to 73.45 | 7.34 0.33 to 223 | 7.12 0.31 to 215 | 6.86 0.60 to 92.11 | 6.82 0.87 to 63.83 | 6.43 1.31 to 47.05 | 5.71 0.82 to 56.10 | 5.63 0.71 to 54.85 | 5.24 0.78 to 50.40 | 5.32 0.54 to 61.17 | 4.72 0.73 to 44.30 | 4.67 0.67 to 41.81 | 3.94 0.64 to 32.80 | 3.81 0.51 to 35.45 | 3.69 0.63 to 30.34 | 3.07 0.54 to 25.93 | 3.01 0.07 to 75.47 | 3.00 0.29 to 36.14 | 2.92 0.24 to 39.89 | 2.87 0.23 to 35.70 | 2.70 0.06 to 111 | 2.55 1.01 to 6.73 | 2.53 0.39 to 19.69 | 1.88 0.32 to 15.85 | 1.81 0.31 to 15.07 | 1.84 0.10 to 32.81 | 1.78 0.30 to 14.31 | 1.45 0.13 to 18.56 | 1.23 0.53 to 2.89 | DANU_PO_200MG_BID |
Heterogeneity, fit and convergence
Bayesian random effects (primary)
Inconsistency
No comparison here has both direct and indirect evidence, so inconsistency cannot be checked by node splitting.
Small study effects
Fewer than ten trial comparisons, too few to judge funnel plot asymmetry.
Baseline characteristics of the trials
| Trial | Sex (percent female) effect modifier, prognostic factor; 24 of 24 | Asian ancestry or region (percent Asian) effect modifier, prognostic factor; 20 of 24 |
|---|---|---|
| TOGETHER-PsO S000032 | 44.9 | 3.3 |
| STEP 1 S000144 | 74.07 | 13.33 |
| STEP 5 S000214 | 77.6 | 0.65 |
| NCT04707313 S000279 | 63.4 | 10.8 |
| NCT03041792 S000418 | 67.69 | 1.81 |
| NCT05579977 S000448 | 52.05 | 13.22 |
| VENTURE S000714 | 73.86 | 2.29 |
| NCT05616013 S000715 | 57.37 | 2.97 |
| NCT02075281 S000743 | 76.35 | 8.49 |
| NCT02160990 S000865 | 65 | not reported |
| ACCESS S000899 | 54.35 | 1.74 |
| NCT04478708 S001178 | 33.33 | 1.52 |
| NCT04904913 S001183 | 52.03 | 100 |
| Dapalost S001235 | 61.25 | not reported |
| NCT03856047 S001532 | 61.75 | 13.03 |
| NCT05623839 S001559 | 50 | not reported |
| TOGETHER-PsA S001889 | 69.75 | 2.2 |
| SURMOUNT-3 S002157 | 62.9 | 0.7 |
| NCT06250946 S002275 | 48.49 | 100 region: all sites in Asia |
| NCT06569355 S002553 | 41.59 | 97.22 Asian subgroup rows |
| FALCON S002590 | 79.04 | 0.6 |
| NCT04838405 S002824 | 56.25 | 12.5 |
| S003032 S003032 | 67.5 | not reported |
| NCT04855292 S003063 | 37.5 | 100 region: all sites in Asia |
Comparability of the trials
- FlagBaseline, Sex: design means range from 33.3 (MARI_SC_140MG_Q4W vs MARI_SC_280MG_Q4W vs MARI_SC_420MG_Q4W vs PLACEBO) to 79.0 (PLACEBO vs TERN60_PO_250MG_QD vs TERN60_PO_500MG_QD vs TERN60_PO_750MG_QD) percent female; threshold 15
- FlagBaseline, Asian ancestry or region: design means range from 0.6 (PLACEBO vs TERN60_PO_250MG_QD vs TERN60_PO_500MG_QD vs TERN60_PO_750MG_QD) to 100.0 (HRS7535_PO_120MG_QD vs HRS7535_PO_180MG_QD vs HRS7535_PO_30MG_QD vs HRS7535_PO_60MG_QD vs PLACEBO) percent Asian; threshold 30
- NoteOutcome assessment, time point: selected time points span 4.29 to 111 weeks
- NoteOutcome assessment, analysis set: mixed: completers 1, randomized 2, safety 21
- NoteOutcome assessment, intercurrent events (discontinuation): mixed: not stated 23, while_on_treatment 1
- NoteOutcome assessment, intercurrent events (rescue): mixed: not stated 23, treatment_policy 1
- NoteRisk of bias, blinding: mixed: double_blind 20, open_label 3, single_blind 1
- NoteRisk of bias, funding: mixed: industry 22, non_industry 2
- NoteData handling, input conversions: arms_combined 10, printed_denominator 8
| Trial | time weeks | analysis set | definition | start year | instrument | adjudicated | proportion method | intercurrent events (discontinuation) | intercurrent events (rescue) | blinding | funding | Eligibility |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TOGETHER-PsO | 36 | safety | not stated | 2024 | not stated | not stated | not stated | not stated | not stated | open_label | industry | adults; moderate to severe plaque psoriasis; PASI 12 or more; BMI 30 or more, or 27 to 30 with comorbidity |
| STEP 1 | 68 | safety | not stated | 2018 | not stated | not stated | not stated | while_on_treatment | treatment_policy | double_blind | industry | adults; BMI 30 or more, or 27 or more with a weight related condition; no diabetes; HbA1c below 6.5 percent |
| STEP 5 | 111 | safety | not stated | 2018 | not stated | not stated | not stated | not stated | not stated | double_blind | industry | age 18 or older; BMI 30 or more, or 27 or more with comorbidity; no diabetes; HbA1c below 6.5 percent |
| NCT04707313 | 37 | safety | not stated | 2021 | not stated | not stated | not stated | not stated | not stated | double_blind | industry | age 18 to 75; BMI 30 or higher; no diabetes; stable weight |
| NCT03041792 | 10.43 | safety | not stated | 2017 | not stated | not stated | not stated | not stated | not stated | double_blind | industry | age 18 to 75; BMI 30 to 40; no diabetes; HbA1c below 6.5 percent |
| NCT05579977 | 28 | safety | not stated | 2022 | not stated | not stated | not stated | not stated | not stated | double_blind | industry | age 18 to 75; T2D cohort on metformin, HbA1c 7.0 to 10.0, BMI 23 or more; obesity cohort BMI 30 or more without diabetes |
| VENTURE | 19 | safety | not stated | 2023 | not stated | not stated | not stated | not stated | not stated | double_blind | industry | age over 18; BMI 30 or more, or 27 or more with comorbidity; BMI 50 or less; no diabetes |
| NCT05616013 | 48 | safety | not stated | 2022 | not stated | not stated | not stated | not stated | not stated | open_label | industry | adults 18 to 80; BMI 30 or more, or 27 or more with comorbidity; no diabetes (HbA1c below 6.5 percent); weight below 150 kg |
| NCT02075281 | 20 | safety | not stated | 2014 | not stated | not stated | not stated | not stated | not stated | double_blind | industry | age 18 to 64 years; BMI 30 to 42, or 27 to 30 with comorbidity; FPG below 7 mmol/L; HbA1c 6.5 percent or less; no diabetes |
| NCT02160990 | 4.29 | randomized | not stated | 2014 | not stated | not stated | not stated | not stated | not stated | double_blind | non_industry | Adults; BMI 30 to 40; accelerated gastric emptying; no diabetes |
| ACCESS | 36 | safety | not stated | 2024 | not stated | not stated | not stated | not stated | not stated | double_blind | industry | age 18 to 79; BMI 30 or more, or 27 or more with comorbidity; HbA1c below 6.5 percent; weight above 80 kg; no diabetes |
| NCT04478708 | 29.43 | safety | not stated | 2020 | not stated | not stated | not stated | not stated | not stated | double_blind | industry | age 18 to 65; BMI 30 to 40; HbA1c at most 6.5 or fasting glucose below 125 mg/dL |
| NCT04904913 | 36 | safety | not stated | 2021 | not stated | not stated | not stated | not stated | not stated | double_blind | industry | Chinese adults 18 to 75; BMI 28 or more, or 24 or more with comorbidity or hyperphagia; no diabetes, HbA1c below 6.5 |
| Dapalost | 24 | safety | not stated | 2014 | not stated | not stated | not stated | not stated | not stated | double_blind | industry | age 18 to 70; BMI 30 to 45 kg/m2; no diabetes |
| NCT03856047 | 26 | safety | not stated | 2019 | not stated | not stated | not stated | not stated | not stated | double_blind | industry | age 18 or older; BMI 30 or more, or 27 or more with hypertension or dyslipidemia; no diabetes |
| NCT05623839 | 27 | safety | not stated | 2022 | not stated | not stated | not stated | not stated | not stated | double_blind | industry | age 18 to 70; BMI 27 to 50; HbA1c below 6.5 percent; no diabetes |
| TOGETHER-PsA | 36 | safety | not stated | 2024 | not stated | not stated | not stated | not stated | not stated | single_blind | industry | age 18 to 80; active psoriatic arthritis; BMI 30 or more, or 27 to 30 with a weight related comorbidity |
| SURMOUNT-3 | 72 | safety | not stated | 2021 | not stated | not stated | not stated | not stated | not stated | double_blind | industry | age 18 or older; BMI 30 or more, or 27 or more with comorbidity; no diabetes; at least 5 percent loss in lead in |
| NCT06250946 | 36 | safety | not stated | 2024 | not stated | not stated | not stated | not stated | not stated | double_blind | industry | age 18 to 65; BMI 28 to 40; no diabetes, HbA1c below 6.5 percent |
| NCT06569355 | 18 | safety | not stated | 2023 | not stated | not stated | not stated | not stated | not stated | double_blind | industry | age 18 to 75; BMI 28 or more, or 24 to 28 with comorbidity; no diabetes |
| FALCON | 16 | safety | not stated | 2025 | not stated | not stated | not stated | not stated | not stated | double_blind | industry | age 18 to 75; BMI 27 to below 50 with comorbidity if below 30; HbA1c below 6.5 |
| NCT04838405 | 6 | randomized | not stated | 2021 | not stated | not stated | not stated | not stated | not stated | double_blind | industry | age 18 to 65, BMI 25 or more (30 or more in cohorts 7 and 8), no diabetes |
| S003032 | 52.14 | completers | not stated | not stated | not stated | not stated | not stated | not stated | open_label | non_industry | age 18 to 65; BMI 27 or higher; scheduled for intragastric balloon | |
| NCT04855292 | 14 | safety | not stated | 2021 | not stated | not stated | not stated | not stated | not stated | double_blind | industry | age 18 to 75; BMI 26 or more; weight 60 kg or more; HbA1c below 6.5; no diabetes |
Trial data
| Trial | Arm | Treatment | Week | Data | Value | SE | Events / N | Flags | Source |
|---|---|---|---|---|---|---|---|---|---|
| TOGETHER-PsO | A1 | STANDARD_CARE | 36 | arm, events | 2 / 134 | printed_denominator | R0014237:Table 3 | ||
| TOGETHER-PsO | A2 | TIRZ_SC_MTD_5-10-15_QW | 36 | arm, events | 5 / 138 | printed_denominator | R0014237:Table 3 | ||
| STEP 1 | A1 | SEMA_SC_2p4MG_QW | 68 | arm, events | 92 / 1,306 | R0023399:Table 3 | |||
| STEP 1 | A2 | PLACEBO | 68 | arm, events | 20 / 655 | R0023399:Table 3 | |||
| STEP 5 | A1 | SEMA_SC_2p4MG_QW | 111 | arm, events | 9 / 152 | R0021896:Table 3 | |||
| STEP 5 | A2 | PLACEBO | 111 | arm, events | 7 / 152 | R0021896:Table 3 | |||
| NCT04707313 | A11 | DANU_PO_80MG_BID | 37 | arm, events | 9 / 37 | R0005921:Table 2 | |||
| NCT04707313 | A12 | DANU_PO_140MG_BID | 37 | arm, events | 16 / 37 | R0005921:Table 2 | |||
| NCT04707313 | A13 | DANU_PO_200MG_BID | 37 | arm, events | 18 / 36 | R0005921:Table 2 | |||
| NCT04707313 | A2 | PLACEBO | 37 | arm, events | 0 / 19 | R0005921:Table 2 | |||
| NCT03041792 | A1 | LIRA_SC_3p0MG_QD | 10.43 | arm, events | 4 / 32 | R0023522:Table 2 | |||
| NCT03041792 | A2 | PLACEBO | 10.43 | arm, events | 0 / 29 | R0023522:Table 2 | |||
| NCT05579977 | A1+A8 | PLACEBO | 28 | arm, events | 5 / 139 | arms_combined | R0004106:Supplement Table S3 | ||
| NCT05579977 | A10 | LOTI_PO_140MG_QD | 28 | arm, events | 19 / 64 | R0004106:Supplement Table S3 | |||
| NCT05579977 | A11+A12 | LOTI_PO_200MG_QD | 28 | arm, events | 39 / 131 | arms_combined | R0004106:Supplement Table S3 | ||
| NCT05579977 | A13+A6 | LOTI_PO_260MG_QD | 28 | arm, events | 39 / 138 | arms_combined | R0004106:Supplement Table S3 | ||
| NCT05579977 | A2 | LOTI_PO_20MG_QD | 28 | arm, events | 3 / 73 | R0004106:Supplement Table S3 | |||
| NCT05579977 | A3 | LOTI_PO_40MG_QD | 28 | arm, events | 11 / 72 | R0004106:Supplement Table S3 | |||
| NCT05579977 | A4+A9 | LOTI_PO_80MG_QD | 28 | arm, events | 22 / 139 | arms_combined | R0004106:Supplement Table S3 | ||
| NCT05579977 | A5 | LOTI_PO_160MG_QD | 28 | arm, events | 5 / 73 | R0004106:Supplement Table S3 | |||
| NCT05579977 | A7 | SEMA_PO_14MG_QD | 28 | arm, events | 5 / 73 | R0004106:Supplement Table S3 | |||
| VENTURE | A1 | PLACEBO | 19 | arm, events | 0 / 35 | R0011224:Table 3 | |||
| VENTURE | A2 | VK2735_SC_2p5MG_QW | 19 | arm, events | 1 / 35 | R0011224:Table 3 | |||
| VENTURE | A3 | VK2735_SC_5p0MG_QW | 19 | arm, events | 4 / 35 | R0011224:Table 3 | |||
| VENTURE | A4 | VK2735_SC_10MG_QW | 19 | arm, events | 4 / 36 | R0011224:Table 3 | |||
| VENTURE | A5 | VK2735_SC_15MG_QW | 19 | arm, events | 7 / 35 | R0011224:Table 3 | |||
| NCT05616013 | A1 | PLACEBO | 48 | arm, events | 2 / 56 | R0015266:Table 3 | |||
| NCT05616013 | A2+A3 | OTHER_ACTIVE_bimagrumab | 48 | arm, events | 20 / 113 | arms_combined | R0015266:Table 3 | ||
| NCT05616013 | A4 | SEMA_SC_1p0MG_QW | 48 | arm, events | 2 / 56 | R0015266:Table 3 | |||
| NCT05616013 | A5 | SEMA_SC_2p4MG_QW | 48 | arm, events | 5 / 57 | R0015266:Table 3 | |||
| NCT05616013 | A6 | BIMASEMA_SC_1p0-10MG_QW | 48 | arm, events | 6 / 56 | R0015266:Table 3 | |||
| NCT05616013 | A7 | BIMASEMA_SC_2p4-10MG_QW | 48 | arm, events | 3 / 56 | R0015266:Table 3 | |||
| NCT05616013 | A8 | BIMASEMA_SC_1p0-30MG_QW | 48 | arm, events | 7 / 56 | R0015266:Table 3 | |||
| NCT05616013 | A9 | BIMASEMA_SC_2p4-30MG_QW | 48 | arm, events | 3 / 57 | R0015266:Table 3 | |||
| NCT02075281 | A1 | PLACEBO | 20 | arm, events | 4 / 60 | R0011218:Table 3 | |||
| NCT02075281 | A2 | EFPE_SC_4MG_QW | 20 | arm, events | 3 / 59 | R0011218:Table 3 | |||
| NCT02075281 | A3 | EFPE_SC_6MG_QW | 20 | arm, events | 11 / 59 | R0011218:Table 3 | |||
| NCT02075281 | A4 | EFPE_SC_6MG_Q2W | 20 | arm, events | 7 / 59 | R0011218:Table 3 | |||
| NCT02075281 | A5 | EFPE_SC_8MG_Q2W | 20 | arm, events | 10 / 60 | R0011218:Table 3 | |||
| NCT02160990 | A1 | PLACEBO | 4.29 | arm, events | 0 / 10 | R0020690:Results | |||
| NCT02160990 | A2 | EXEN_SC_5UG_BID | 4.29 | arm, events | 0 / 10 | R0020690:Results | |||
| ACCESS | A1 | ALENIG_PO_45MG_QD | 36 | arm, events | 6 / 45 | R0000892:Table 2 | |||
| ACCESS | A2 | ALENIG_PO_90MG_QD | 36 | arm, events | 5 / 65 | R0000892:Table 2 | |||
| ACCESS | A3 | ALENIG_PO_120MG_QD | 36 | arm, events | 7 / 64 | R0000892:Table 2 | |||
| ACCESS | A4 | PLACEBO | 36 | arm, events | 3 / 56 | R0000892:Table 2 | |||
| NCT04478708 | A10 | MARI_SC_280MG_Q4W | 29.43 | arm, events | 0 / 6 | printed_denominator | R0006305:Results | ||
| NCT04478708 | A11 | MARI_SC_420MG_Q4W | 29.43 | arm, events | 0 / 8 | printed_denominator | R0006305:Results | ||
| NCT04478708 | A8 | PLACEBO | 29.43 | arm, events | 0 / 6 | printed_denominator | R0006305:Results | ||
| NCT04478708 | A9 | MARI_SC_140MG_Q4W | 29.43 | arm, events | 0 / 6 | printed_denominator | R0006305:Results | ||
| NCT04904913 | A1 | MAZD_SC_3MG_QW | 36 | arm, events | 0 / 62 | R0016107:Table 4 | |||
| NCT04904913 | A2 | MAZD_SC_4p5MG_QW | 36 | arm, events | 1 / 63 | R0016107:Table 4 | |||
| NCT04904913 | A3 | MAZD_SC_6MG_QW | 36 | arm, events | 0 / 61 | R0016107:Table 4 | |||
| NCT04904913 | A4 | PLACEBO | 36 | arm, events | 0 / 62 | R0016107:Table 4 | |||
| Dapalost | A1 | EXENER_SC_2-10MG_QW | 24 | arm, events | 2 / 25 | R0025627:Table 3 | |||
| Dapalost | A2 | PLACEBO | 24 | arm, events | 3 / 25 | R0025627:Table 3 | |||
| NCT03856047 | A1+A2+A3+A4+A5 | OTHER_ACTIVE_cagrilintide | 26 | arm, events | 19 / 506 | arms_combined | R0017871:Table 3 | ||
| NCT03856047 | A6 | LIRA_SC_3p0MG_QD | 26 | arm, events | 7 / 99 | R0017871:Table 3 | |||
| NCT03856047 | A7 | PLACEBO | 26 | arm, events | 3 / 101 | R0017871:Table 3 | |||
| NCT05623839 | A1 | PLACEBO | 27 | arm, events | 0 / 8 | R0013210:Results | |||
| NCT05623839 | A2+A3 | MAZD_SC_16MG_QW | 27 | arm, events | 3 / 24 | arms_combined | R0013210:Results | ||
| TOGETHER-PsA | A1 | STANDARD_CARE | 36 | arm, events | 7 / 132 | printed_denominator | R0018951:Table 3 | ||
| TOGETHER-PsA | A2 | TIRZ_SC_MTD_5-10-15_QW | 36 | arm, events | 7 / 138 | printed_denominator | R0018951:Table 3 | ||
| SURMOUNT-3 | A1 | TIRZ_SC_MTD_QW | 72 | arm, events | 30 / 287 | R0007405:Table 3 | |||
| SURMOUNT-3 | A2 | PLACEBO | 72 | arm, events | 6 / 292 | R0007405:Table 3 | |||
| NCT06250946 | A1 | PLACEBO | 36 | arm, events | 0 / 46 | R0001289:Table 6 | |||
| NCT06250946 | A2 | HRS7535_PO_30MG_QD | 36 | arm, events | 1 / 48 | R0001289:Table 6 | |||
| NCT06250946 | A3 | HRS7535_PO_60MG_QD | 36 | arm, events | 1 / 47 | R0001289:Table 6 | |||
| NCT06250946 | A4 | HRS7535_PO_120MG_QD | 36 | arm, events | 0 / 46 | R0001289:Table 6 | |||
| NCT06250946 | A5 | HRS7535_PO_180MG_QD | 36 | arm, events | 3 / 48 | R0001289:Table 6 | |||
| NCT06569355 | A1 | VCT220_PO_80MG_QD | 18 | arm, events | 1 / 65 | R0001121:Table 3 | |||
| NCT06569355 | A2 | VCT220_PO_120MG_QD | 18 | arm, events | 1 / 62 | R0001121:Table 3 | |||
| NCT06569355 | A3+A4 | VCT220_PO_160MG_QD | 18 | arm, events | 1 / 62 | arms_combined | R0001121:Table 3 | ||
| NCT06569355 | A5 | PLACEBO | 18 | arm, events | 1 / 61 | R0001121:Table 3 | |||
| FALCON | A1 | PLACEBO | 16 | arm, events | 1 / 33 | R0004304:Supplement Table S8 | |||
| FALCON | A2 | TERN60_PO_250MG_QD | 16 | arm, events | 3 / 33 | R0004304:Supplement Table S8 | |||
| FALCON | A3+A4 | TERN60_PO_500MG_QD | 16 | arm, events | 7 / 68 | arms_combined | R0004304:Supplement Table S8 | ||
| FALCON | A5 | TERN60_PO_750MG_QD | 16 | arm, events | 6 / 33 | R0004304:Supplement Table S8 | |||
| NCT04838405 | A10+A9 | CT388_SC_12MG_QW | 6 | arm, events | 0 / 12 | arms_combined | R0007991:Table 3 | ||
| NCT04838405 | A7 | PLACEBO | 6 | arm, events | 0 / 6 | R0007991:Table 3 | |||
| NCT04838405 | A8 | CT388_SC_7p5MG_QW | 6 | arm, events | 0 / 6 | R0007991:Table 3 | |||
| S003032 | A1 | STANDARD_CARE | 52.14 | arm, events | 0 / 25 | R0015729:Table 2 | |||
| S003032 | A2 | SEMA_SC_1p0MG_QW | 52.14 | arm, events | 0 / 25 | R0015729:Table 2 | |||
| NCT04855292 | A1 | TG103_SC_15MG_QW | 14 | arm, events | 0 / 12 | R0022276:Results | |||
| NCT04855292 | A2 | TG103_SC_22p5MG_QW | 14 | arm, events | 0 / 12 | R0022276:Results | |||
| NCT04855292 | A3 | TG103_SC_30MG_QW | 14 | arm, events | 0 / 12 | R0022276:Results | |||
| NCT04855292 | A4 | PLACEBO | 14 | arm, events | 0 / 12 | R0022276:Results |
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