LivingGLP1
Oral small molecule GLP-1 receptor agonist

Vct220 po

VCT220_PO

Mechanism
Nonpeptide GLP-1 receptor agonist (orforglipron; danuglipron; lotiglipron; aleniglipron and others)
Trials
1
Participants in these arms
127

Effects across outcomes

Bayesian random effects estimate against the comparator of each analysis (usually placebo), posterior median and 95% credible interval. Green: clearly better; red: clearly worse.
ConditionOutcomeWindowVersusEffect (95% CrI)SUCRA
Overweight or obesity without diabetes (adults)Serious adverse eventslongest follow-upPlaceboHR 3.61 (0.29 to 114)0.30
Overweight or obesity without diabetes (adults)Discontinuation due to adverse eventslongest follow-upPlaceboHR 0.99 (0.14 to 11.88)0.68
Overweight or obesity without diabetes (adults)Nausealongest follow-upPlaceboHR 6.80 (2.96 to 19.15)0.23
Overweight or obesity without diabetes (adults)Vomitinglongest follow-upPlaceboHR 3.79 (1.35 to 11.85)0.57
Overweight or obesity without diabetes (adults)Diarrhealongest follow-upPlaceboHR 2.55 (0.95 to 8.59)0.38

Trials