Network meta-analysis

Systolic blood pressure change

Type 2 diabetes (adults)

weeks 20 to 36 (target week 26)Not stated by the trialsEach dose separatelyMean difference

Randomized trials

Treatments

33,062

Participants

172

Trial arms

In plain language

Across 67 trials with 33,062 participants, 22 of 43 treatments had a clearly better result than placebo on systolic blood pressure change, and for 21 the evidence could not tell them apart from placebo. The most favorable estimate was for Liraglutide and metformin 1.2 to 1500 mg injection once daily: mean difference -7.68 mmHg (95% credible interval -11.47 to -3.80).

Lower values favor the treatment. "Clearly" means the 95% credible interval excludes no difference. These are averages across trials; they do not say how any one person will respond. Not medical advice.

Network of trials

Each circle is a treatment; each line joins treatments that were randomized against each other in at least one trial.

Node area shows participants; line width shows trials comparing two treatments directly. Blue: GLP-1 receptor agonist containing treatments; grey: comparators. Hover over or tab to a node or line for details.

Effects compared with Placebo

Mean difference in mmHg. Lower values favor the treatment.

Versus Placebo. Blue: Bayesian random effects posterior median with 95% credible interval (thick) and 95% prediction interval (dashed). Amber diamond: frequentist estimate with 95% confidence interval. Hover over or tab to a row for its values.

Effects of each treatment versus Placebo
Treatment	Bayesian MD (95% CrI)	95% prediction interval	Frequentist MD (95% CI)	Verdict
Liraglutide and metformin 1.2 to 1500 mg injection once daily LIRAMETF_SC_1p2-1500MG_QD	-7.68 (-11.47 to -3.80)	-11.79 to -3.65	-7.84 (-11.71 to -3.97)	Better
Liraglutide after insulin degludec 0.9 mg injection once daily LIRAGL_SC_0p9MG_QD	-7.44 (-13.08 to -1.81)	-13.31 to -1.55	-7.68 (-13.41 to -1.95)	Better
Polyethylene glycol loxenatide 0.2 mg subcutaneous once weekly PEGLOX_SC_0p2MG_QW	-5.95 (-9.99 to -1.85)	-10.26 to -1.54	-6.08 (-10.29 to -1.87)	Better
Exenatide extended release and dapagliflozin 2 to 10 mg injection once weekly DAPAEXEN_SC_2-10MG_QW	-5.77 (-8.75 to -2.85)	-9.04 to -2.51	-5.93 (-8.95 to -2.92)	Better
Liraglutide flexible dose injection once daily LIRA_SC_FLEX_0p6-1p2-1p8_QD	-5.66 (-9.24 to -2.10)	-9.49 to -1.83	-5.84 (-9.46 to -2.22)	Better
Liraglutide flexible dose injection once daily LIRA_SC_FLEX_1p2-1p8_QD	-4.85 (-7.65 to -2.06)	-8.05 to -1.68	-4.94 (-7.86 to -2.02)	Better
Semaglutide 14 mg oral once daily (original tablet) SEMA_PO_14MG_QD	-4.17 (-5.89 to -2.41)	-6.41 to -1.86	-4.16 (-5.94 to -2.38)	Better
Tirzepatide 5 mg subcutaneous once weekly TIRZ_SC_5MG_QW	-3.87 (-8.50 to 0.89)	-8.65 to 1.19	-3.94 (-8.72 to 0.83)	Unclear
Semaglutide 1.0 mg subcutaneous once weekly SEMA_SC_1p0MG_QW	-3.52 (-5.01 to -2.04)	-5.72 to -1.38	-3.59 (-5.14 to -2.04)	Better
Liraglutide 1.8 mg subcutaneous once daily LIRA_SC_1p8MG_QD	-3.41 (-4.57 to -2.18)	-5.32 to -1.41	-3.50 (-4.73 to -2.26)	Better
Dapagliflozin DAPAGLIFLOZIN	-3.35 (-6.02 to -0.62)	-6.44 to -0.26	-3.48 (-6.32 to -0.65)	Better
Ebenatide 2 mg injection once weekly EBENAT_SC_2MG_QW	-3.33 (-8.97 to 2.38)	-9.09 to 2.49	-3.56 (-9.33 to 2.21)	Unclear
Taspoglutide 10 mg subcutaneous once weekly TASP_SC_10MG_QW	-3.19 (-5.97 to -0.33)	-6.38 to 0.04	-3.25 (-6.12 to -0.38)	Better
Semaglutide 7 mg oral once daily (original tablet) SEMA_PO_7MG_QD	-3.11 (-5.08 to -1.11)	-5.60 to -0.54	-3.16 (-5.20 to -1.12)	Better
Exenatide 10 ug subcutaneous twice daily EXEN_SC_10UG_BID	-2.78 (-4.28 to -1.32)	-4.96 to -0.70	-2.93 (-4.49 to -1.38)	Better
Insulin degludec and liraglutide (IDegLira) subcutaneous once daily titrated IDEGLIRA_SC_TIT_QD	-2.68 (-4.62 to -0.84)	-5.19 to -0.29	-2.82 (-4.73 to -0.91)	Better
Exenatide extended release 2 mg subcutaneous once weekly EXENER_SC_2MG_QW	-2.67 (-3.99 to -1.33)	-4.70 to -0.64	-2.78 (-4.18 to -1.37)	Better
Liraglutide 1.2 mg subcutaneous once daily LIRA_SC_1p2MG_QD	-2.63 (-4.66 to -0.61)	-5.16 to -0.04	-2.70 (-4.79 to -0.61)	Better
Tirzepatide 10 mg subcutaneous once weekly TIRZ_SC_10MG_QW	-2.57 (-7.30 to 2.15)	-7.47 to 2.47	-2.64 (-7.51 to 2.22)	Unclear
Taspoglutide 20 mg subcutaneous once weekly TASP_SC_20MG_QW	-2.48 (-5.32 to 0.32)	-5.69 to 0.67	-2.55 (-5.41 to 0.31)	Unclear
Dulaglutide 1.5 mg subcutaneous once weekly DULA_SC_1p5MG_QW	-2.45 (-3.53 to -1.37)	-4.28 to -0.55	-2.52 (-3.62 to -1.41)	Better
Semaglutide 0.5 mg subcutaneous once weekly SEMA_SC_0p5MG_QW	-2.38 (-4.10 to -0.56)	-4.68 to 0.05	-2.40 (-4.22 to -0.58)	Better
Pioglitazone PIOGLITAZONE	-2.31 (-4.40 to -0.16)	-4.84 to 0.36	-2.41 (-4.63 to -0.20)	Better
Liraglutide 0.9 mg injection once daily LIRA_SC_0p9MG_QD	-2.27 (-4.05 to -0.45)	-4.57 to 0.13	-2.35 (-4.21 to -0.49)	Better
Tirzepatide 15 mg subcutaneous once weekly TIRZ_SC_15MG_QW	-2.22 (-7.06 to 2.49)	-7.32 to 2.74	-2.34 (-7.33 to 2.64)	Unclear
Sitagliptin SITAGLIPTIN	-2.07 (-3.41 to -0.60)	-4.10 to 0.02	-2.14 (-3.58 to -0.70)	Better
Dulaglutide 0.75 mg subcutaneous once weekly DULA_SC_0p75MG_QW	-1.68 (-2.82 to -0.59)	-3.53 to 0.22	-1.75 (-2.91 to -0.59)	Better
Tirzepatide 1 mg subcutaneous once weekly TIRZ_SC_1MG_QW	-1.27 (-6.12 to 3.58)	-6.28 to 3.81	-1.34 (-6.27 to 3.58)	Unclear
Dpp4 inhibitor OTHER_ACTIVE_dpp4_inhibitor	-1.23 (-11.77 to 9.38)	-11.82 to 9.48	-2.06 (-12.92 to 8.81)	Unclear
Premixed insulin INS_PREMIX	-0.79 (-6.58 to 4.94)	-6.70 to 5.12	-1.07 (-6.87 to 4.73)	Unclear
Glimepiride GLIMEPIRIDE	-0.75 (-3.21 to 1.71)	-3.67 to 2.14	-0.82 (-3.42 to 1.79)	Unclear
Semaglutide 3 mg oral once daily (original tablet) SEMA_PO_3MG_QD	-0.61 (-2.27 to 1.08)	-2.86 to 1.64	-0.62 (-2.35 to 1.11)	Unclear
Albiglutide flexible dose injection once weekly ALBI_SC_FLEX_30-50_QW	-0.49 (-2.20 to 1.28)	-2.77 to 1.80	-0.50 (-2.28 to 1.28)	Unclear
Insulin degludec INS_DEGLUDEC	-0.43 (-2.91 to 1.89)	-3.37 to 2.37	-0.57 (-3.03 to 1.88)	Unclear
Metformin METFORMIN	-0.10 (-1.80 to 1.72)	-2.29 to 2.23	-0.18 (-1.99 to 1.62)	Unclear
Polyethylene glycol loxenatide 400 µg injection once weekly PEGLOX_SC_400UG_QW	0.06 (-9.89 to 9.59)	-10.00 to 9.67	0.05 (-9.81 to 9.91)	Unclear
Insulin glargine INS_GLARGINE	0.07 (-1.15 to 1.31)	-1.90 to 2.07	-0.01 (-1.27 to 1.24)	Unclear
Polyethylene glycol loxenatide 300 µg injection once weekly PEGLOX_SC_300UG_QW	1.34 (-8.59 to 10.82)	-8.65 to 10.87	1.27 (-8.56 to 11.10)	Unclear
Insulin lispro (prandial) INS_LISPRO	1.69 (-1.39 to 4.72)	-1.76 to 5.04	1.45 (-1.62 to 4.53)	Unclear
Insulin detemir INS_DETEMIR	1.73 (-2.43 to 6.00)	-2.72 to 6.25	1.62 (-2.67 to 5.91)	Unclear
Gliclazide GLICLAZIDE	2.14 (-4.70 to 9.03)	-4.76 to 9.19	1.97 (-5.01 to 8.95)	Unclear
Standard care or no added treatment STANDARD_CARE	2.51 (-1.70 to 6.78)	-1.99 to 6.96	2.26 (-2.03 to 6.55)	Unclear
Lixisenatide 20 ug subcutaneous once daily LIXI_SC_20UG_QD	3.17 (-3.09 to 9.47)	-3.31 to 9.67	3.10 (-3.33 to 9.53)	Unclear

Ranking

How likely each treatment is to be among the best. Rankings ignore the size of differences and their certainty, so read them with the effects above.

League table

Every treatment against every other: mean difference of the row treatment versus the column treatment, posterior median and 95% credible interval. Green: row clearly better; red: row clearly worse.

Every treatment in a row compared with every treatment in a column
Row versus column	PLACEBO	LIRAMETF_SC_1p2-1500MG_QD	LIRAGL_SC_0p9MG_QD	PEGLOX_SC_0p2MG_QW	DAPAEXEN_SC_2-10MG_QW	LIRA_SC_FLEX_0p6-1p2-1p8_QD	LIRA_SC_FLEX_1p2-1p8_QD	SEMA_PO_14MG_QD	TIRZ_SC_5MG_QW	SEMA_SC_1p0MG_QW	LIRA_SC_1p8MG_QD	DAPAGLIFLOZIN	EBENAT_SC_2MG_QW	TASP_SC_10MG_QW	SEMA_PO_7MG_QD	EXEN_SC_10UG_BID	IDEGLIRA_SC_TIT_QD	EXENER_SC_2MG_QW	LIRA_SC_1p2MG_QD	TIRZ_SC_10MG_QW	TASP_SC_20MG_QW	DULA_SC_1p5MG_QW	SEMA_SC_0p5MG_QW	PIOGLITAZONE	LIRA_SC_0p9MG_QD	TIRZ_SC_15MG_QW	SITAGLIPTIN	DULA_SC_0p75MG_QW	TIRZ_SC_1MG_QW	OTHER_ACTIVE_dpp4_inhibitor	INS_PREMIX	GLIMEPIRIDE	SEMA_PO_3MG_QD	ALBI_SC_FLEX_30-50_QW	INS_DEGLUDEC	METFORMIN	PEGLOX_SC_400UG_QW	INS_GLARGINE	PEGLOX_SC_300UG_QW	INS_LISPRO	INS_DETEMIR	GLICLAZIDE	STANDARD_CARE	LIXI_SC_20UG_QD
PLACEBO	PLACEBO	7.68 3.80 to 11.47	7.44 1.81 to 13.08	5.95 1.85 to 9.99	5.77 2.85 to 8.75	5.66 2.10 to 9.24	4.85 2.06 to 7.65	4.17 2.41 to 5.89	3.87 -0.89 to 8.50	3.52 2.04 to 5.01	3.41 2.18 to 4.57	3.35 0.62 to 6.02	3.33 -2.38 to 8.97	3.19 0.33 to 5.97	3.11 1.11 to 5.08	2.78 1.32 to 4.28	2.68 0.84 to 4.62	2.67 1.33 to 3.99	2.63 0.61 to 4.66	2.57 -2.15 to 7.30	2.48 -0.32 to 5.32	2.45 1.37 to 3.53	2.38 0.56 to 4.10	2.31 0.16 to 4.40	2.27 0.45 to 4.05	2.22 -2.49 to 7.06	2.07 0.60 to 3.41	1.68 0.59 to 2.82	1.27 -3.58 to 6.12	1.23 -9.38 to 11.77	0.79 -4.94 to 6.58	0.75 -1.71 to 3.21	0.61 -1.08 to 2.27	0.49 -1.28 to 2.20	0.43 -1.89 to 2.91	0.10 -1.72 to 1.80	-0.06 -9.59 to 9.89	-0.07 -1.31 to 1.15	-1.34 -10.82 to 8.59	-1.69 -4.72 to 1.39	-1.73 -6.00 to 2.43	-2.14 -9.03 to 4.70	-2.51 -6.78 to 1.70	-3.17 -9.47 to 3.09
LIRAMETF_SC_1p2-1500MG_QD	-7.68 -11.47 to -3.80	LIRAMETF_SC_1p2-1500MG_QD	-0.23 -6.99 to 6.62	-1.72 -7.06 to 3.74	-1.86 -6.63 to 2.69	-2.00 -6.10 to 2.09	-2.81 -7.43 to 1.70	-3.47 -7.80 to 0.75	-3.83 -9.92 to 2.27	-4.13 -8.12 to -0.10	-4.27 -7.99 to -0.61	-4.27 -8.74 to 0.12	-4.36 -11.02 to 2.46	-4.49 -9.11 to 0.19	-4.55 -8.94 to -0.30	-4.87 -8.88 to -0.86	-4.98 -9.02 to -0.84	-5.00 -8.93 to -1.19	-5.05 -9.25 to -0.86	-5.10 -11.13 to 0.90	-5.18 -9.82 to -0.56	-5.22 -9.00 to -1.46	-5.29 -9.39 to -1.21	-5.35 -9.54 to -1.28	-5.38 -9.44 to -1.34	-5.36 -11.59 to 0.78	-5.61 -9.45 to -1.81	-5.97 -9.83 to -2.16	-6.37 -12.51 to -0.21	-6.39 -17.87 to 4.79	-6.93 -13.70 to 0.06	-6.91 -11.38 to -2.48	-7.03 -11.33 to -2.85	-7.20 -11.35 to -3.10	-7.20 -11.56 to -2.80	-7.57 -11.30 to -3.92	-7.74 -17.98 to 2.78	-7.73 -11.57 to -3.84	-8.99 -19.20 to 1.69	-9.33 -14.09 to -4.58	-9.40 -14.99 to -4.00	-9.82 -17.46 to -2.32	-10.16 -15.79 to -4.61	-10.87 -18.16 to -3.60
LIRAGL_SC_0p9MG_QD	-7.44 -13.08 to -1.81	0.23 -6.62 to 6.99	LIRAGL_SC_0p9MG_QD	-1.53 -8.32 to 5.48	-1.68 -7.89 to 4.70	-1.81 -8.30 to 4.85	-2.59 -8.77 to 3.66	-3.24 -9.19 to 2.69	-3.63 -10.79 to 3.62	-3.91 -9.72 to 1.91	-4.03 -9.70 to 1.65	-4.09 -10.23 to 2.15	-4.11 -12.24 to 4.12	-4.26 -10.47 to 1.97	-4.34 -10.27 to 1.63	-4.67 -10.48 to 1.08	-4.74 -10.63 to 1.10	-4.76 -10.48 to 0.99	-4.80 -10.66 to 1.11	-4.91 -12.06 to 2.21	-4.96 -11.15 to 1.44	-4.96 -10.68 to 0.67	-5.09 -10.90 to 0.85	-5.14 -11.15 to 0.84	-5.16 -10.57 to 0.28	-5.24 -12.51 to 2.13	-5.38 -11.10 to 0.45	-5.74 -11.33 to -0.02	-6.18 -13.73 to 1.07	-6.20 -18.43 to 5.88	-6.65 -14.61 to 1.61	-6.73 -12.72 to -0.55	-6.83 -12.75 to -0.91	-6.94 -12.89 to -1.11	-6.99 -12.95 to -0.95	-7.34 -13.23 to -1.59	-7.51 -18.72 to 4.04	-7.47 -13.15 to -1.78	-8.79 -19.69 to 2.62	-9.09 -15.42 to -2.85	-9.24 -16.03 to -2.21	-9.59 -18.49 to -0.67	-9.95 -16.89 to -3.05	-10.69 -19.20 to -2.08
PEGLOX_SC_0p2MG_QW	-5.95 -9.99 to -1.85	1.72 -3.74 to 7.06	1.53 -5.48 to 8.32	PEGLOX_SC_0p2MG_QW	-0.16 -4.15 to 3.86	-0.29 -5.42 to 4.86	-1.12 -5.83 to 3.63	-1.82 -6.17 to 2.63	-2.05 -8.39 to 4.03	-2.44 -6.54 to 1.76	-2.54 -6.57 to 1.44	-2.62 -5.56 to 0.44	-2.64 -9.60 to 4.42	-2.81 -7.59 to 2.07	-2.85 -7.25 to 1.66	-3.19 -7.23 to 0.96	-3.25 -7.41 to 1.01	-3.28 -7.19 to 0.61	-3.30 -7.52 to 0.95	-3.38 -9.72 to 2.78	-3.50 -8.19 to 1.52	-3.48 -7.54 to 0.56	-3.58 -7.83 to 0.76	-3.64 -7.98 to 0.61	-3.68 -8.01 to 0.67	-3.74 -10.04 to 2.56	-3.92 -7.94 to 0.20	-4.27 -8.34 to -0.21	-4.66 -10.99 to 1.49	-4.70 -16.15 to 6.91	-5.20 -11.98 to 1.65	-5.17 -9.86 to -0.54	-5.33 -9.58 to -1.01	-5.48 -9.81 to -1.10	-5.51 -10.05 to -0.93	-5.86 -10.11 to -1.63	-6.06 -16.24 to 4.49	-6.02 -10.02 to -1.99	-7.27 -17.47 to 3.30	-7.65 -12.46 to -2.68	-7.69 -13.45 to -2.14	-8.14 -16.01 to -0.20	-8.43 -14.08 to -2.70	-9.18 -16.64 to -1.59
DAPAEXEN_SC_2-10MG_QW	-5.77 -8.75 to -2.85	1.86 -2.69 to 6.63	1.68 -4.70 to 7.89	0.16 -3.86 to 4.15	DAPAEXEN_SC_2-10MG_QW	-0.16 -4.42 to 4.37	-0.92 -4.71 to 2.89	-1.58 -5.01 to 1.70	-1.93 -7.41 to 3.45	-2.24 -5.32 to 0.88	-2.39 -5.28 to 0.50	-2.44 -5.06 to 0.21	-2.42 -8.84 to 3.99	-2.58 -6.55 to 1.31	-2.67 -6.29 to 0.77	-2.99 -5.94 to 0.04	-3.07 -6.27 to 0.14	-3.11 -5.74 to -0.52	-3.13 -6.42 to 0.09	-3.23 -8.73 to 2.25	-3.30 -7.14 to 0.63	-3.31 -6.27 to -0.40	-3.38 -6.74 to -0.12	-3.45 -6.79 to -0.27	-3.49 -6.88 to -0.33	-3.52 -9.19 to 2.09	-3.73 -6.67 to -0.85	-4.07 -7.03 to -1.14	-4.50 -10.23 to 1.21	-4.55 -15.76 to 6.40	-5.01 -11.21 to 1.33	-5.02 -8.78 to -1.36	-5.14 -8.53 to -1.73	-5.32 -8.64 to -1.96	-5.31 -8.85 to -1.76	-5.67 -8.86 to -2.64	-5.83 -15.85 to 4.44	-5.84 -8.78 to -2.87	-7.10 -17.10 to 3.28	-7.47 -11.38 to -3.37	-7.54 -12.27 to -2.78	-7.93 -15.07 to -0.72	-8.28 -13.25 to -3.32	-8.96 -15.97 to -1.96
LIRA_SC_FLEX_0p6-1p2-1p8_QD	-5.66 -9.24 to -2.10	2.00 -2.09 to 6.10	1.81 -4.85 to 8.30	0.29 -4.86 to 5.42	0.16 -4.37 to 4.42	LIRA_SC_FLEX_0p6-1p2-1p8_QD	-0.79 -5.13 to 3.46	-1.47 -5.47 to 2.46	-1.79 -7.63 to 3.99	-2.10 -5.90 to 1.60	-2.24 -5.68 to 1.13	-2.29 -6.53 to 1.97	-2.30 -8.95 to 4.41	-2.49 -6.88 to 1.91	-2.54 -6.64 to 1.48	-2.86 -6.61 to 0.80	-2.94 -6.79 to 0.85	-2.97 -6.62 to 0.52	-2.98 -7.08 to 0.83	-3.07 -9.00 to 2.75	-3.16 -7.51 to 1.26	-3.17 -6.83 to 0.32	-3.25 -7.13 to 0.55	-3.34 -7.29 to 0.47	-3.37 -7.28 to 0.37	-3.41 -9.20 to 2.50	-3.60 -7.17 to -0.09	-3.95 -7.61 to -0.44	-4.39 -10.29 to 1.62	-4.40 -15.75 to 6.90	-4.92 -11.50 to 1.68	-4.85 -9.16 to -0.74	-5.02 -9.00 to -1.17	-5.17 -9.11 to -1.32	-5.18 -9.28 to -1.05	-5.55 -8.98 to -2.28	-5.72 -15.72 to 4.72	-5.67 -9.34 to -2.16	-6.93 -17.14 to 3.38	-7.31 -11.85 to -2.77	-7.42 -12.81 to -2.11	-7.79 -15.37 to -0.35	-8.16 -13.56 to -2.79	-8.89 -16.07 to -1.60
LIRA_SC_FLEX_1p2-1p8_QD	-4.85 -7.65 to -2.06	2.81 -1.70 to 7.43	2.59 -3.66 to 8.77	1.12 -3.63 to 5.83	0.92 -2.89 to 4.71	0.79 -3.46 to 5.13	LIRA_SC_FLEX_1p2-1p8_QD	-0.69 -3.96 to 2.60	-0.99 -6.44 to 4.20	-1.37 -4.31 to 1.74	-1.46 -4.12 to 1.25	-1.50 -5.18 to 2.17	-1.50 -7.83 to 4.67	-1.70 -5.26 to 1.99	-1.75 -5.18 to 1.59	-2.07 -4.97 to 0.93	-2.18 -5.29 to 0.94	-2.19 -4.95 to 0.58	-2.22 -5.28 to 1.03	-2.28 -7.74 to 3.06	-2.37 -6.05 to 1.31	-2.39 -5.15 to 0.42	-2.49 -5.67 to 0.71	-2.54 -5.75 to 0.56	-2.57 -5.74 to 0.47	-2.65 -8.05 to 2.86	-2.79 -5.21 to -0.35	-3.17 -5.91 to -0.32	-3.57 -9.14 to 1.95	-3.58 -14.56 to 7.27	-4.12 -10.21 to 2.26	-4.11 -7.75 to -0.52	-4.25 -7.49 to -1.02	-4.37 -7.63 to -1.18	-4.42 -7.86 to -0.92	-4.77 -7.77 to -1.82	-4.88 -14.71 to 5.34	-4.92 -7.75 to -2.12	-6.16 -15.84 to 3.95	-6.52 -10.42 to -2.51	-6.60 -11.51 to -1.66	-7.02 -14.31 to 0.21	-7.37 -12.26 to -2.34	-8.08 -14.83 to -1.00
SEMA_PO_14MG_QD	-4.17 -5.89 to -2.41	3.47 -0.75 to 7.80	3.24 -2.69 to 9.19	1.82 -2.63 to 6.17	1.58 -1.70 to 5.01	1.47 -2.46 to 5.47	0.69 -2.60 to 3.96	SEMA_PO_14MG_QD	-0.33 -5.33 to 4.66	-0.64 -2.89 to 1.69	-0.77 -2.83 to 1.24	-0.82 -4.05 to 2.38	-0.82 -6.78 to 5.01	-0.99 -4.33 to 2.25	-1.05 -3.13 to 1.06	-1.39 -3.64 to 0.89	-1.49 -3.96 to 1.10	-1.50 -3.65 to 0.63	-1.54 -4.20 to 1.11	-1.61 -6.68 to 3.44	-1.70 -4.92 to 1.65	-1.70 -3.73 to 0.30	-1.79 -4.26 to 0.66	-1.87 -4.59 to 0.86	-1.88 -4.32 to 0.48	-1.92 -6.92 to 3.15	-2.11 -4.29 to 0.08	-2.49 -4.51 to -0.44	-2.88 -8.08 to 2.28	-2.86 -13.63 to 7.64	-3.42 -9.37 to 2.57	-3.41 -6.45 to -0.38	-3.56 -5.47 to -1.65	-3.68 -6.12 to -1.23	-3.75 -6.65 to -0.70	-4.09 -6.50 to -1.63	-4.24 -13.97 to 5.94	-4.22 -6.35 to -2.10	-5.52 -15.06 to 4.57	-5.86 -9.25 to -2.26	-5.90 -10.38 to -1.39	-6.33 -13.47 to 0.73	-6.69 -11.27 to -2.14	-7.34 -13.86 to -0.77
TIRZ_SC_5MG_QW	-3.87 -8.50 to 0.89	3.83 -2.27 to 9.92	3.63 -3.62 to 10.79	2.05 -4.03 to 8.39	1.93 -3.45 to 7.41	1.79 -3.99 to 7.63	0.99 -4.20 to 6.44	0.33 -4.66 to 5.33	TIRZ_SC_5MG_QW	-0.30 -5.19 to 4.52	-0.47 -5.20 to 4.33	-0.50 -5.76 to 4.96	-0.53 -7.77 to 6.81	-0.68 -6.04 to 4.65	-0.76 -5.64 to 4.36	-1.07 -5.90 to 3.71	-1.19 -6.12 to 3.89	-1.20 -6.00 to 3.60	-1.24 -6.24 to 3.80	-1.29 -6.80 to 4.12	-1.33 -6.65 to 3.97	-1.36 -6.02 to 3.30	-1.46 -6.32 to 3.47	-1.52 -6.52 to 3.47	-1.56 -6.51 to 3.37	-1.62 -6.93 to 3.94	-1.77 -6.55 to 3.01	-2.15 -6.85 to 2.54	-2.56 -8.04 to 2.86	-2.58 -14.17 to 9.04	-3.10 -10.34 to 4.28	-3.09 -8.29 to 2.09	-3.24 -8.33 to 1.71	-3.34 -8.33 to 1.72	-3.42 -8.55 to 1.76	-3.77 -8.61 to 1.16	-3.92 -14.44 to 6.92	-3.92 -8.63 to 0.88	-5.10 -15.73 to 5.86	-5.52 -11.08 to 0.02	-5.54 -11.92 to 0.57	-5.96 -14.41 to 2.03	-6.38 -12.66 to 0.06	-7.12 -14.89 to 0.98
SEMA_SC_1p0MG_QW	-3.52 -5.01 to -2.04	4.13 0.10 to 8.12	3.91 -1.91 to 9.72	2.44 -1.76 to 6.54	2.24 -0.88 to 5.32	2.10 -1.60 to 5.90	1.37 -1.74 to 4.31	0.64 -1.69 to 2.89	0.30 -4.52 to 5.19	SEMA_SC_1p0MG_QW	-0.12 -1.81 to 1.53	-0.16 -3.18 to 2.67	-0.21 -6.21 to 5.60	-0.34 -3.42 to 2.77	-0.42 -2.95 to 2.00	-0.75 -2.71 to 1.18	-0.84 -2.93 to 1.35	-0.86 -2.65 to 0.85	-0.89 -2.91 to 1.05	-0.98 -5.81 to 3.94	-1.05 -4.11 to 2.06	-1.06 -2.77 to 0.57	-1.16 -2.86 to 0.53	-1.21 -3.75 to 1.22	-1.25 -3.48 to 0.95	-1.30 -6.24 to 3.79	-1.46 -3.29 to 0.31	-1.83 -3.56 to -0.18	-2.25 -7.31 to 2.76	-2.30 -13.05 to 8.27	-2.76 -8.58 to 3.18	-2.78 -5.64 to 0.00	-2.92 -5.14 to -0.71	-3.05 -5.34 to -0.79	-3.09 -5.67 to -0.44	-3.44 -5.58 to -1.36	-3.60 -13.22 to 6.46	-3.59 -5.17 to -2.00	-4.85 -14.55 to 5.19	-5.21 -8.51 to -1.90	-5.27 -9.69 to -0.91	-5.65 -12.69 to 1.23	-6.06 -10.39 to -1.65	-6.71 -13.14 to -0.16
LIRA_SC_1p8MG_QD	-3.41 -4.57 to -2.18	4.27 0.61 to 7.99	4.03 -1.65 to 9.70	2.54 -1.44 to 6.57	2.39 -0.50 to 5.28	2.24 -1.13 to 5.68	1.46 -1.25 to 4.12	0.77 -1.24 to 2.83	0.47 -4.33 to 5.20	0.12 -1.53 to 1.81	LIRA_SC_1p8MG_QD	-0.05 -2.79 to 2.55	-0.06 -5.85 to 5.65	-0.21 -3.04 to 2.64	-0.29 -2.59 to 1.95	-0.62 -2.18 to 0.96	-0.70 -2.42 to 1.00	-0.74 -1.90 to 0.45	-0.77 -2.73 to 1.23	-0.84 -5.64 to 3.93	-0.92 -3.77 to 2.06	-0.93 -2.14 to 0.24	-1.02 -2.94 to 0.90	-1.10 -3.12 to 0.95	-1.14 -2.96 to 0.66	-1.19 -5.92 to 3.73	-1.34 -2.56 to -0.16	-1.71 -2.97 to -0.44	-2.13 -7.02 to 2.73	-2.13 -12.83 to 8.45	-2.61 -8.42 to 3.13	-2.64 -5.17 to -0.09	-2.79 -4.84 to -0.74	-2.93 -4.98 to -0.86	-2.96 -5.14 to -0.66	-3.31 -4.97 to -1.66	-3.45 -12.96 to 6.49	-3.46 -4.66 to -2.27	-4.75 -14.26 to 5.32	-5.09 -8.12 to -1.97	-5.12 -9.34 to -1.04	-5.53 -12.34 to 1.27	-5.90 -10.15 to -1.73	-6.59 -12.97 to -0.01
DAPAGLIFLOZIN	-3.35 -6.02 to -0.62	4.27 -0.12 to 8.74	4.09 -2.15 to 10.23	2.62 -0.44 to 5.56	2.44 -0.21 to 5.06	2.29 -1.97 to 6.53	1.50 -2.17 to 5.18	0.82 -2.38 to 4.05	0.50 -4.96 to 5.76	0.16 -2.67 to 3.18	0.05 -2.55 to 2.79	DAPAGLIFLOZIN	-0.01 -6.39 to 6.38	-0.16 -3.99 to 3.57	-0.25 -3.56 to 3.08	-0.57 -3.37 to 2.32	-0.66 -3.66 to 2.39	-0.68 -3.12 to 1.78	-0.72 -3.65 to 2.26	-0.78 -6.22 to 4.60	-0.87 -4.51 to 2.87	-0.88 -3.61 to 1.88	-0.97 -4.01 to 2.13	-1.01 -4.25 to 1.99	-1.07 -4.16 to 1.99	-1.09 -6.65 to 4.35	-1.31 -4.04 to 1.38	-1.67 -4.38 to 1.07	-2.09 -7.64 to 3.39	-2.09 -12.97 to 8.72	-2.57 -8.75 to 3.66	-2.59 -6.14 to 0.94	-2.75 -5.91 to 0.48	-2.89 -6.05 to 0.38	-2.93 -6.18 to 0.52	-3.27 -6.26 to -0.31	-3.45 -13.16 to 6.79	-3.41 -6.10 to -0.62	-4.75 -14.52 to 5.64	-5.04 -8.80 to -1.08	-5.09 -9.90 to -0.48	-5.53 -12.78 to 1.59	-5.87 -10.74 to -1.01	-6.54 -13.31 to 0.38
EBENAT_SC_2MG_QW	-3.33 -8.97 to 2.38	4.36 -2.46 to 11.02	4.11 -4.12 to 12.24	2.64 -4.42 to 9.60	2.42 -3.99 to 8.84	2.30 -4.41 to 8.95	1.50 -4.67 to 7.83	0.82 -5.01 to 6.78	0.53 -6.81 to 7.77	0.21 -5.60 to 6.21	0.06 -5.65 to 5.85	0.01 -6.38 to 6.39	EBENAT_SC_2MG_QW	-0.15 -6.45 to 6.08	-0.19 -6.37 to 5.91	-0.52 -6.34 to 5.40	-0.60 -6.51 to 5.37	-0.66 -6.45 to 5.09	-0.68 -6.68 to 5.38	-0.76 -8.11 to 6.57	-0.83 -7.11 to 5.53	-0.87 -6.64 to 5.03	-0.96 -6.87 to 4.99	-1.02 -7.04 to 4.97	-1.06 -7.05 to 4.95	-1.04 -8.35 to 6.23	-1.27 -7.05 to 4.55	-1.63 -7.36 to 4.23	-2.03 -9.40 to 5.43	-2.09 -14.04 to 9.94	-2.55 -10.64 to 5.56	-2.59 -8.59 to 3.61	-2.73 -8.57 to 3.17	-2.84 -8.71 to 3.07	-2.90 -8.94 to 3.34	-3.27 -9.23 to 2.74	-3.31 -14.55 to 7.92	-3.39 -9.17 to 2.42	-4.59 -15.78 to 6.71	-5.03 -11.28 to 1.37	-5.07 -12.06 to 1.96	-5.41 -14.64 to 3.09	-5.80 -12.80 to 1.28	-6.51 -15.13 to 2.11
TASP_SC_10MG_QW	-3.19 -5.97 to -0.33	4.49 -0.19 to 9.11	4.26 -1.97 to 10.47	2.81 -2.07 to 7.59	2.58 -1.31 to 6.55	2.49 -1.91 to 6.88	1.70 -1.99 to 5.26	0.99 -2.25 to 4.33	0.68 -4.65 to 6.04	0.34 -2.77 to 3.42	0.21 -2.64 to 3.04	0.16 -3.57 to 3.99	0.15 -6.08 to 6.45	TASP_SC_10MG_QW	-0.08 -3.50 to 3.32	-0.39 -3.43 to 2.67	-0.50 -3.63 to 2.70	-0.53 -3.38 to 2.38	-0.55 -3.84 to 2.71	-0.61 -5.98 to 4.78	-0.70 -3.62 to 2.28	-0.73 -3.63 to 2.16	-0.80 -3.99 to 2.37	-0.87 -4.12 to 2.40	-0.93 -4.14 to 2.33	-0.97 -6.41 to 4.57	-1.12 -3.84 to 1.56	-1.51 -4.38 to 1.45	-1.92 -7.51 to 3.58	-1.91 -12.80 to 9.05	-2.42 -8.72 to 4.02	-2.40 -6.16 to 1.23	-2.57 -5.87 to 0.70	-2.72 -5.88 to 0.60	-2.74 -6.30 to 0.81	-3.09 -6.29 to -0.01	-3.28 -13.05 to 6.98	-3.25 -6.13 to -0.33	-4.48 -14.38 to 5.71	-4.87 -8.90 to -0.79	-4.93 -9.88 to 0.00	-5.33 -12.67 to 2.07	-5.71 -10.72 to -0.71	-6.38 -13.45 to 0.57
SEMA_PO_7MG_QD	-3.11 -5.08 to -1.11	4.55 0.30 to 8.94	4.34 -1.63 to 10.27	2.85 -1.66 to 7.25	2.67 -0.77 to 6.29	2.54 -1.48 to 6.64	1.75 -1.59 to 5.18	1.05 -1.06 to 3.13	0.76 -4.36 to 5.64	0.42 -2.00 to 2.95	0.29 -1.95 to 2.59	0.25 -3.08 to 3.56	0.19 -5.91 to 6.37	0.08 -3.32 to 3.50	SEMA_PO_7MG_QD	-0.31 -2.75 to 2.18	-0.42 -3.10 to 2.39	-0.45 -2.74 to 1.94	-0.49 -3.29 to 2.33	-0.53 -5.58 to 4.61	-0.62 -3.93 to 2.85	-0.65 -2.85 to 1.62	-0.71 -3.42 to 1.97	-0.80 -3.68 to 2.15	-0.84 -3.39 to 1.78	-0.85 -6.07 to 4.32	-1.06 -3.43 to 1.35	-1.41 -3.66 to 0.84	-1.80 -7.22 to 3.40	-1.83 -12.37 to 8.50	-2.30 -8.37 to 3.73	-2.36 -5.46 to 0.73	-2.49 -4.62 to -0.42	-2.62 -5.24 to -0.04	-2.68 -5.78 to 0.53	-3.02 -5.60 to -0.37	-3.16 -13.05 to 7.06	-3.17 -5.46 to -0.84	-4.48 -14.12 to 5.65	-4.78 -8.41 to -1.09	-4.82 -9.39 to -0.26	-5.22 -12.47 to 1.92	-5.63 -10.32 to -0.96	-6.26 -12.78 to 0.29
EXEN_SC_10UG_BID	-2.78 -4.28 to -1.32	4.87 0.86 to 8.88	4.67 -1.08 to 10.48	3.19 -0.96 to 7.23	2.99 -0.04 to 5.94	2.86 -0.80 to 6.61	2.07 -0.93 to 4.97	1.39 -0.89 to 3.64	1.07 -3.71 to 5.90	0.75 -1.18 to 2.71	0.62 -0.96 to 2.18	0.57 -2.32 to 3.37	0.52 -5.40 to 6.34	0.39 -2.67 to 3.43	0.31 -2.18 to 2.75	EXEN_SC_10UG_BID	-0.09 -2.12 to 1.92	-0.13 -1.63 to 1.38	-0.16 -2.50 to 2.15	-0.20 -5.14 to 4.66	-0.29 -3.34 to 2.85	-0.31 -1.91 to 1.18	-0.41 -2.54 to 1.77	-0.48 -2.84 to 1.85	-0.51 -2.67 to 1.59	-0.57 -5.47 to 4.34	-0.72 -2.52 to 0.99	-1.10 -2.68 to 0.44	-1.50 -6.53 to 3.50	-1.54 -12.26 to 9.05	-2.03 -7.60 to 3.54	-2.04 -4.76 to 0.69	-2.17 -4.39 to 0.04	-2.30 -4.63 to -0.14	-2.34 -4.78 to 0.19	-2.71 -4.74 to -0.67	-2.91 -12.42 to 7.04	-2.85 -4.41 to -1.30	-4.10 -13.71 to 6.01	-4.44 -7.11 to -1.75	-4.52 -8.89 to -0.30	-4.94 -11.89 to 1.94	-5.29 -9.50 to -1.18	-6.01 -12.44 to 0.61
IDEGLIRA_SC_TIT_QD	-2.68 -4.62 to -0.84	4.98 0.84 to 9.02	4.74 -1.10 to 10.63	3.25 -1.01 to 7.41	3.07 -0.14 to 6.27	2.94 -0.85 to 6.79	2.18 -0.94 to 5.29	1.49 -1.10 to 3.96	1.19 -3.89 to 6.12	0.84 -1.35 to 2.93	0.70 -1.00 to 2.42	0.66 -2.39 to 3.66	0.60 -5.37 to 6.51	0.50 -2.70 to 3.63	0.42 -2.39 to 3.10	0.09 -1.92 to 2.12	IDEGLIRA_SC_TIT_QD	-0.04 -1.91 to 1.83	-0.07 -2.49 to 2.38	-0.15 -5.08 to 4.88	-0.19 -3.49 to 2.97	-0.24 -2.09 to 1.55	-0.32 -2.64 to 2.01	-0.39 -2.93 to 2.16	-0.41 -2.76 to 1.88	-0.48 -5.52 to 4.64	-0.62 -2.63 to 1.31	-1.01 -2.85 to 0.82	-1.41 -6.57 to 3.67	-1.49 -12.12 to 9.32	-1.90 -7.80 to 4.10	-1.93 -4.78 to 0.83	-2.09 -4.60 to 0.40	-2.18 -4.81 to 0.23	-2.24 -3.96 to -0.56	-2.61 -4.87 to -0.41	-2.79 -12.22 to 7.30	-2.75 -4.30 to -1.30	-4.02 -13.68 to 6.16	-4.37 -7.72 to -0.92	-4.42 -8.86 to -0.12	-4.83 -11.81 to 2.18	-5.21 -9.75 to -0.77	-5.88 -12.41 to 0.74
EXENER_SC_2MG_QW	-2.67 -3.99 to -1.33	5.00 1.19 to 8.93	4.76 -0.99 to 10.48	3.28 -0.61 to 7.19	3.11 0.52 to 5.74	2.97 -0.52 to 6.62	2.19 -0.58 to 4.95	1.50 -0.63 to 3.65	1.20 -3.60 to 6.00	0.86 -0.85 to 2.65	0.74 -0.45 to 1.90	0.68 -1.78 to 3.12	0.66 -5.09 to 6.45	0.53 -2.38 to 3.38	0.45 -1.94 to 2.74	0.13 -1.38 to 1.63	0.04 -1.83 to 1.91	EXENER_SC_2MG_QW	-0.04 -2.08 to 2.04	-0.10 -4.89 to 4.73	-0.17 -3.08 to 2.69	-0.20 -1.61 to 1.17	-0.29 -2.31 to 1.69	-0.34 -2.31 to 1.53	-0.37 -2.41 to 1.56	-0.43 -5.25 to 4.49	-0.61 -1.92 to 0.67	-0.99 -2.37 to 0.46	-1.39 -6.39 to 3.54	-1.41 -12.07 to 9.24	-1.89 -7.71 to 3.82	-1.92 -4.53 to 0.76	-2.06 -4.16 to 0.06	-2.19 -4.35 to 0.01	-2.21 -4.57 to 0.19	-2.57 -4.28 to -0.90	-2.75 -12.39 to 7.27	-2.73 -4.01 to -1.43	-4.01 -13.69 to 6.07	-4.35 -7.39 to -1.23	-4.41 -8.48 to -0.42	-4.82 -11.59 to 2.04	-5.15 -9.50 to -1.01	-5.87 -12.20 to 0.64
LIRA_SC_1p2MG_QD	-2.63 -4.66 to -0.61	5.05 0.86 to 9.25	4.80 -1.11 to 10.66	3.30 -0.95 to 7.52	3.13 -0.09 to 6.42	2.98 -0.83 to 7.08	2.22 -1.03 to 5.28	1.54 -1.11 to 4.20	1.24 -3.80 to 6.24	0.89 -1.05 to 2.91	0.77 -1.23 to 2.73	0.72 -2.26 to 3.65	0.68 -5.38 to 6.68	0.55 -2.71 to 3.84	0.49 -2.33 to 3.29	0.16 -2.15 to 2.50	0.07 -2.38 to 2.49	0.04 -2.04 to 2.08	LIRA_SC_1p2MG_QD	-0.05 -5.10 to 5.00	-0.14 -3.40 to 3.14	-0.17 -2.30 to 1.93	-0.26 -2.63 to 2.12	-0.33 -3.05 to 2.43	-0.34 -2.92 to 2.14	-0.39 -5.45 to 4.84	-0.57 -2.64 to 1.42	-0.94 -3.08 to 1.18	-1.35 -6.55 to 3.74	-1.41 -12.17 to 9.49	-1.86 -7.89 to 4.15	-1.89 -4.98 to 1.20	-2.02 -4.65 to 0.59	-2.16 -4.77 to 0.54	-2.19 -4.98 to 0.72	-2.54 -5.03 to -0.16	-2.71 -12.35 to 7.41	-2.70 -4.75 to -0.64	-4.00 -13.68 to 6.19	-4.30 -7.88 to -0.72	-4.36 -8.82 to 0.13	-4.74 -11.85 to 2.23	-5.15 -9.76 to -0.54	-5.84 -12.49 to 0.98
TIRZ_SC_10MG_QW	-2.57 -7.30 to 2.15	5.10 -0.90 to 11.13	4.91 -2.21 to 12.06	3.38 -2.78 to 9.72	3.23 -2.25 to 8.73	3.07 -2.75 to 9.00	2.28 -3.06 to 7.74	1.61 -3.44 to 6.68	1.29 -4.12 to 6.80	0.98 -3.94 to 5.81	0.84 -3.93 to 5.64	0.78 -4.60 to 6.22	0.76 -6.57 to 8.11	0.61 -4.78 to 5.98	0.53 -4.61 to 5.58	0.20 -4.66 to 5.14	0.15 -4.88 to 5.08	0.10 -4.73 to 4.89	0.05 -5.00 to 5.10	TIRZ_SC_10MG_QW	-0.06 -5.49 to 5.36	-0.12 -4.80 to 4.60	-0.22 -5.19 to 4.81	-0.26 -5.35 to 4.83	-0.28 -5.33 to 4.64	-0.33 -5.80 to 5.30	-0.52 -5.40 to 4.35	-0.90 -5.60 to 3.81	-1.31 -6.84 to 4.29	-1.33 -13.03 to 10.46	-1.80 -9.11 to 5.76	-1.79 -7.15 to 3.39	-1.96 -7.01 to 3.03	-2.08 -7.06 to 2.90	-2.13 -7.36 to 3.11	-2.50 -7.39 to 2.38	-2.58 -12.88 to 8.15	-2.63 -7.43 to 2.16	-3.87 -14.73 to 7.32	-4.23 -9.84 to 1.34	-4.32 -10.57 to 2.01	-4.66 -13.13 to 3.63	-5.02 -11.54 to 1.17	-5.79 -13.60 to 2.19
TASP_SC_20MG_QW	-2.48 -5.32 to 0.32	5.18 0.56 to 9.82	4.96 -1.44 to 11.15	3.50 -1.52 to 8.19	3.30 -0.63 to 7.14	3.16 -1.26 to 7.51	2.37 -1.31 to 6.05	1.70 -1.65 to 4.92	1.33 -3.97 to 6.65	1.05 -2.06 to 4.11	0.92 -2.06 to 3.77	0.87 -2.87 to 4.51	0.83 -5.53 to 7.11	0.70 -2.28 to 3.62	0.62 -2.85 to 3.93	0.29 -2.85 to 3.34	0.19 -2.97 to 3.49	0.17 -2.69 to 3.08	0.14 -3.14 to 3.40	0.06 -5.36 to 5.49	TASP_SC_20MG_QW	-0.03 -2.97 to 2.83	-0.13 -3.38 to 3.17	-0.16 -3.54 to 3.08	-0.22 -3.52 to 2.99	-0.25 -5.70 to 5.16	-0.43 -3.23 to 2.24	-0.82 -3.70 to 2.12	-1.20 -6.69 to 4.20	-1.29 -12.29 to 9.84	-1.69 -8.19 to 4.56	-1.75 -5.36 to 1.95	-1.86 -5.17 to 1.37	-2.02 -5.28 to 1.27	-2.06 -5.51 to 1.50	-2.39 -5.69 to 0.70	-2.51 -12.55 to 7.74	-2.55 -5.47 to 0.32	-3.81 -13.73 to 6.45	-4.18 -8.19 to -0.10	-4.22 -9.11 to 0.64	-4.58 -12.13 to 2.68	-5.03 -10.07 to 0.02	-5.68 -12.59 to 1.18
DULA_SC_1p5MG_QW	-2.45 -3.53 to -1.37	5.22 1.46 to 9.00	4.96 -0.67 to 10.68	3.48 -0.56 to 7.54	3.31 0.40 to 6.27	3.17 -0.32 to 6.83	2.39 -0.42 to 5.15	1.70 -0.30 to 3.73	1.36 -3.30 to 6.02	1.06 -0.57 to 2.77	0.93 -0.24 to 2.14	0.88 -1.88 to 3.61	0.87 -5.03 to 6.64	0.73 -2.16 to 3.63	0.65 -1.62 to 2.85	0.31 -1.18 to 1.91	0.24 -1.55 to 2.09	0.20 -1.17 to 1.61	0.17 -1.93 to 2.30	0.12 -4.60 to 4.80	0.03 -2.83 to 2.97	DULA_SC_1p5MG_QW	-0.08 -1.98 to 1.82	-0.15 -2.32 to 1.97	-0.19 -2.05 to 1.65	-0.21 -4.98 to 4.59	-0.40 -1.88 to 1.03	-0.78 -1.72 to 0.20	-1.19 -6.05 to 3.64	-1.25 -11.87 to 9.33	-1.69 -7.44 to 4.07	-1.72 -4.05 to 0.61	-1.87 -3.79 to 0.15	-1.98 -4.02 to -0.02	-2.01 -4.34 to 0.36	-2.36 -4.08 to -0.67	-2.54 -11.97 to 7.50	-2.52 -3.64 to -1.37	-3.84 -13.28 to 6.19	-4.13 -7.12 to -1.05	-4.20 -8.45 to 0.02	-4.60 -11.43 to 2.21	-4.99 -9.27 to -0.74	-5.65 -12.04 to 0.79
SEMA_SC_0p5MG_QW	-2.38 -4.10 to -0.56	5.29 1.21 to 9.39	5.09 -0.85 to 10.90	3.58 -0.76 to 7.83	3.38 0.12 to 6.74	3.25 -0.55 to 7.13	2.49 -0.71 to 5.67	1.79 -0.66 to 4.26	1.46 -3.47 to 6.32	1.16 -0.53 to 2.86	1.02 -0.90 to 2.94	0.97 -2.13 to 4.01	0.96 -4.99 to 6.87	0.80 -2.37 to 3.99	0.71 -1.97 to 3.42	0.41 -1.77 to 2.54	0.32 -2.01 to 2.64	0.29 -1.69 to 2.31	0.26 -2.12 to 2.63	0.22 -4.81 to 5.19	0.13 -3.17 to 3.38	0.08 -1.82 to 1.98	SEMA_SC_0p5MG_QW	-0.06 -2.72 to 2.57	-0.10 -2.50 to 2.29	-0.13 -5.17 to 5.00	-0.30 -2.41 to 1.74	-0.71 -2.60 to 1.26	-1.09 -6.19 to 4.01	-1.11 -11.95 to 9.70	-1.61 -7.50 to 4.40	-1.64 -4.55 to 1.29	-1.79 -4.16 to 0.65	-1.90 -4.33 to 0.55	-1.93 -4.66 to 0.82	-2.29 -4.66 to -0.01	-2.46 -12.06 to 7.64	-2.44 -4.25 to -0.65	-3.70 -13.37 to 6.41	-4.04 -7.47 to -0.65	-4.12 -8.66 to 0.33	-4.48 -11.53 to 2.49	-4.91 -9.33 to -0.39	-5.54 -11.99 to 1.08
PIOGLITAZONE	-2.31 -4.40 to -0.16	5.35 1.28 to 9.54	5.14 -0.84 to 11.15	3.64 -0.61 to 7.98	3.45 0.27 to 6.79	3.34 -0.47 to 7.29	2.54 -0.56 to 5.75	1.87 -0.86 to 4.59	1.52 -3.47 to 6.52	1.21 -1.22 to 3.75	1.10 -0.95 to 3.12	1.01 -1.99 to 4.25	1.02 -4.97 to 7.04	0.87 -2.40 to 4.12	0.80 -2.15 to 3.68	0.48 -1.85 to 2.84	0.39 -2.16 to 2.93	0.34 -1.53 to 2.31	0.33 -2.43 to 3.05	0.26 -4.83 to 5.35	0.16 -3.08 to 3.54	0.15 -1.97 to 2.32	0.06 -2.57 to 2.72	PIOGLITAZONE	-0.03 -2.60 to 2.52	-0.06 -5.17 to 5.31	-0.26 -2.23 to 1.74	-0.63 -2.78 to 1.57	-1.04 -6.25 to 4.19	-1.08 -12.03 to 9.79	-1.54 -7.51 to 4.45	-1.56 -4.61 to 1.62	-1.68 -4.39 to 1.00	-1.83 -4.59 to 0.91	-1.85 -4.81 to 1.11	-2.21 -4.46 to -0.05	-2.42 -12.15 to 7.78	-2.36 -4.49 to -0.26	-3.60 -13.49 to 6.55	-3.99 -7.45 to -0.38	-4.06 -8.44 to 0.37	-4.45 -11.30 to 2.57	-4.83 -9.44 to -0.29	-5.49 -12.05 to 1.16
LIRA_SC_0p9MG_QD	-2.27 -4.05 to -0.45	5.38 1.34 to 9.44	5.16 -0.28 to 10.57	3.68 -0.67 to 8.01	3.49 0.33 to 6.88	3.37 -0.37 to 7.28	2.57 -0.47 to 5.74	1.88 -0.48 to 4.32	1.56 -3.37 to 6.51	1.25 -0.95 to 3.48	1.14 -0.66 to 2.96	1.07 -1.99 to 4.16	1.06 -4.95 to 7.05	0.93 -2.33 to 4.14	0.84 -1.78 to 3.39	0.51 -1.59 to 2.67	0.41 -1.88 to 2.76	0.37 -1.56 to 2.41	0.34 -2.14 to 2.92	0.28 -4.64 to 5.33	0.22 -2.99 to 3.52	0.19 -1.65 to 2.05	0.10 -2.29 to 2.50	0.03 -2.52 to 2.60	LIRA_SC_0p9MG_QD	-0.07 -4.91 to 5.01	-0.21 -2.21 to 1.83	-0.60 -2.37 to 1.24	-1.02 -6.09 to 4.19	-1.02 -11.76 to 9.64	-1.49 -7.32 to 4.44	-1.54 -4.32 to 1.36	-1.67 -4.07 to 0.79	-1.80 -4.18 to 0.75	-1.83 -4.55 to 1.01	-2.20 -4.45 to 0.04	-2.36 -11.91 to 7.90	-2.34 -4.21 to -0.40	-3.63 -13.22 to 6.43	-3.95 -7.27 to -0.43	-3.98 -8.49 to 0.48	-4.44 -11.45 to 2.54	-4.79 -9.31 to -0.31	-5.46 -12.01 to 1.21
TIRZ_SC_15MG_QW	-2.22 -7.06 to 2.49	5.36 -0.78 to 11.59	5.24 -2.13 to 12.51	3.74 -2.56 to 10.04	3.52 -2.09 to 9.19	3.41 -2.50 to 9.20	2.65 -2.86 to 8.05	1.92 -3.15 to 6.92	1.62 -3.94 to 6.93	1.30 -3.79 to 6.24	1.19 -3.73 to 5.92	1.09 -4.35 to 6.65	1.04 -6.23 to 8.35	0.97 -4.57 to 6.41	0.85 -4.32 to 6.07	0.57 -4.34 to 5.47	0.48 -4.64 to 5.52	0.43 -4.49 to 5.25	0.39 -4.84 to 5.45	0.33 -5.30 to 5.80	0.25 -5.16 to 5.70	0.21 -4.59 to 4.98	0.13 -5.00 to 5.17	0.06 -5.31 to 5.17	0.07 -5.01 to 4.91	TIRZ_SC_15MG_QW	-0.14 -5.18 to 4.62	-0.54 -5.38 to 4.22	-0.98 -6.60 to 4.80	-1.04 -12.75 to 11.01	-1.50 -8.88 to 6.02	-1.48 -6.86 to 3.70	-1.64 -6.75 to 3.45	-1.78 -6.82 to 3.34	-1.78 -7.09 to 3.47	-2.16 -7.25 to 2.75	-2.27 -12.86 to 8.71	-2.28 -7.19 to 2.52	-3.64 -14.09 to 7.50	-3.87 -9.51 to 1.72	-4.01 -10.44 to 2.47	-4.40 -12.92 to 4.02	-4.76 -11.32 to 1.55	-5.47 -13.11 to 2.54
SITAGLIPTIN	-2.07 -3.41 to -0.60	5.61 1.81 to 9.45	5.38 -0.45 to 11.10	3.92 -0.20 to 7.94	3.73 0.85 to 6.67	3.60 0.09 to 7.17	2.79 0.35 to 5.21	2.11 -0.08 to 4.29	1.77 -3.01 to 6.55	1.46 -0.31 to 3.29	1.34 0.16 to 2.56	1.31 -1.38 to 4.04	1.27 -4.55 to 7.05	1.12 -1.56 to 3.84	1.06 -1.35 to 3.43	0.72 -0.99 to 2.52	0.62 -1.31 to 2.63	0.61 -0.67 to 1.92	0.57 -1.42 to 2.64	0.52 -4.35 to 5.40	0.43 -2.24 to 3.23	0.40 -1.03 to 1.88	0.30 -1.74 to 2.41	0.26 -1.74 to 2.23	0.21 -1.83 to 2.21	0.14 -4.62 to 5.18	SITAGLIPTIN	-0.38 -1.81 to 1.14	-0.78 -5.75 to 4.13	-0.82 -11.51 to 9.88	-1.27 -7.08 to 4.63	-1.32 -3.90 to 1.40	-1.46 -3.59 to 0.71	-1.58 -3.77 to 0.60	-1.61 -3.96 to 0.86	-1.97 -3.72 to -0.25	-2.12 -11.75 to 7.87	-2.12 -3.54 to -0.66	-3.39 -12.89 to 6.57	-3.73 -6.81 to -0.49	-3.78 -8.01 to 0.43	-4.20 -11.03 to 2.65	-4.55 -8.92 to -0.27	-5.21 -11.73 to 1.20
DULA_SC_0p75MG_QW	-1.68 -2.82 to -0.59	5.97 2.16 to 9.83	5.74 0.02 to 11.33	4.27 0.21 to 8.34	4.07 1.14 to 7.03	3.95 0.44 to 7.61	3.17 0.32 to 5.91	2.49 0.44 to 4.51	2.15 -2.54 to 6.85	1.83 0.18 to 3.56	1.71 0.44 to 2.97	1.67 -1.07 to 4.38	1.63 -4.23 to 7.36	1.51 -1.45 to 4.38	1.41 -0.84 to 3.66	1.10 -0.44 to 2.68	1.01 -0.82 to 2.85	0.99 -0.46 to 2.37	0.94 -1.18 to 3.08	0.90 -3.81 to 5.60	0.82 -2.12 to 3.70	0.78 -0.20 to 1.72	0.71 -1.26 to 2.60	0.63 -1.57 to 2.78	0.60 -1.24 to 2.37	0.54 -4.22 to 5.38	0.38 -1.14 to 1.81	DULA_SC_0p75MG_QW	-0.42 -5.34 to 4.44	-0.41 -11.03 to 10.16	-0.91 -6.57 to 4.86	-0.94 -3.26 to 1.40	-1.09 -3.07 to 0.90	-1.20 -3.29 to 0.80	-1.24 -3.58 to 1.19	-1.59 -3.34 to 0.07	-1.80 -11.25 to 8.22	-1.75 -2.89 to -0.56	-3.04 -12.50 to 6.90	-3.37 -6.37 to -0.29	-3.44 -7.69 to 0.83	-3.81 -10.82 to 3.05	-4.19 -8.46 to 0.00	-4.92 -11.30 to 1.59
TIRZ_SC_1MG_QW	-1.27 -6.12 to 3.58	6.37 0.21 to 12.51	6.18 -1.07 to 13.73	4.66 -1.49 to 10.99	4.50 -1.21 to 10.23	4.39 -1.62 to 10.29	3.57 -1.95 to 9.14	2.88 -2.28 to 8.08	2.56 -2.86 to 8.04	2.25 -2.76 to 7.31	2.13 -2.73 to 7.02	2.09 -3.39 to 7.64	2.03 -5.43 to 9.40	1.92 -3.58 to 7.51	1.80 -3.40 to 7.22	1.50 -3.50 to 6.53	1.41 -3.67 to 6.57	1.39 -3.54 to 6.39	1.35 -3.74 to 6.55	1.31 -4.29 to 6.84	1.20 -4.20 to 6.69	1.19 -3.64 to 6.05	1.09 -4.01 to 6.19	1.04 -4.19 to 6.25	1.02 -4.19 to 6.09	0.98 -4.80 to 6.60	0.78 -4.13 to 5.75	0.42 -4.44 to 5.34	TIRZ_SC_1MG_QW	-0.00 -11.91 to 11.67	-0.51 -7.99 to 6.98	-0.54 -5.83 to 4.94	-0.70 -5.78 to 4.48	-0.78 -5.92 to 4.34	-0.86 -6.14 to 4.49	-1.22 -6.27 to 3.95	-1.40 -11.80 to 9.46	-1.33 -6.18 to 3.60	-2.58 -13.08 to 8.41	-2.94 -8.61 to 2.77	-3.02 -9.37 to 3.53	-3.43 -11.81 to 4.73	-3.75 -10.17 to 2.61	-4.47 -12.27 to 3.43
OTHER_ACTIVE_dpp4_inhibitor	-1.23 -11.77 to 9.38	6.39 -4.79 to 17.87	6.20 -5.88 to 18.43	4.70 -6.91 to 16.15	4.55 -6.40 to 15.76	4.40 -6.90 to 15.75	3.58 -7.27 to 14.56	2.86 -7.64 to 13.63	2.58 -9.04 to 14.17	2.30 -8.27 to 13.05	2.13 -8.45 to 12.83	2.09 -8.72 to 12.97	2.09 -9.94 to 14.04	1.91 -9.05 to 12.80	1.83 -8.50 to 12.37	1.54 -9.05 to 12.26	1.49 -9.32 to 12.12	1.41 -9.24 to 12.07	1.41 -9.49 to 12.17	1.33 -10.46 to 13.03	1.29 -9.84 to 12.29	1.25 -9.33 to 11.87	1.11 -9.70 to 11.95	1.08 -9.79 to 12.03	1.02 -9.64 to 11.76	1.04 -11.01 to 12.75	0.82 -9.88 to 11.51	0.41 -10.16 to 11.03	0.00 -11.67 to 11.91	OTHER_ACTIVE_dpp4_inhibitor	-0.48 -12.61 to 11.69	-0.55 -11.36 to 10.41	-0.62 -11.24 to 10.06	-0.70 -11.54 to 10.09	-0.74 -11.72 to 10.11	-1.21 -11.92 to 9.61	-1.25 -15.48 to 13.39	-1.29 -11.96 to 9.41	-2.56 -16.83 to 12.25	-2.92 -13.87 to 8.10	-3.02 -14.19 to 8.62	-3.45 -15.94 to 9.29	-3.86 -15.23 to 7.75	-4.46 -17.37 to 8.02
INS_PREMIX	-0.79 -6.58 to 4.94	6.93 -0.06 to 13.70	6.65 -1.61 to 14.61	5.20 -1.65 to 11.98	5.01 -1.33 to 11.21	4.92 -1.68 to 11.50	4.12 -2.26 to 10.21	3.42 -2.57 to 9.37	3.10 -4.28 to 10.34	2.76 -3.18 to 8.58	2.61 -3.13 to 8.42	2.57 -3.66 to 8.75	2.55 -5.56 to 10.64	2.42 -4.02 to 8.72	2.30 -3.73 to 8.37	2.03 -3.54 to 7.60	1.90 -4.10 to 7.80	1.89 -3.82 to 7.71	1.86 -4.15 to 7.89	1.80 -5.76 to 9.11	1.69 -4.56 to 8.19	1.69 -4.07 to 7.44	1.61 -4.40 to 7.50	1.54 -4.45 to 7.51	1.49 -4.44 to 7.32	1.50 -6.02 to 8.88	1.27 -4.63 to 7.08	0.91 -4.86 to 6.57	0.51 -6.98 to 7.99	0.48 -11.69 to 12.61	INS_PREMIX	0.00 -6.15 to 6.08	-0.17 -6.08 to 5.88	-0.29 -6.29 to 5.61	-0.31 -6.44 to 5.79	-0.67 -6.64 to 5.10	-0.89 -12.04 to 10.52	-0.84 -6.63 to 4.88	-2.06 -13.14 to 9.55	-2.43 -8.63 to 3.78	-2.54 -9.47 to 4.44	-2.92 -11.74 to 5.70	-3.30 -10.11 to 3.56	-4.02 -12.54 to 4.66
GLIMEPIRIDE	-0.75 -3.21 to 1.71	6.91 2.48 to 11.38	6.73 0.55 to 12.72	5.17 0.54 to 9.86	5.02 1.36 to 8.78	4.85 0.74 to 9.16	4.11 0.52 to 7.75	3.41 0.38 to 6.45	3.09 -2.09 to 8.29	2.78 -0.00 to 5.64	2.64 0.09 to 5.17	2.59 -0.94 to 6.14	2.59 -3.61 to 8.59	2.40 -1.23 to 6.16	2.36 -0.73 to 5.46	2.04 -0.69 to 4.76	1.93 -0.83 to 4.78	1.92 -0.76 to 4.53	1.89 -1.20 to 4.98	1.79 -3.39 to 7.15	1.75 -1.95 to 5.36	1.72 -0.61 to 4.05	1.64 -1.29 to 4.55	1.56 -1.62 to 4.61	1.54 -1.36 to 4.32	1.48 -3.70 to 6.86	1.32 -1.40 to 3.90	0.94 -1.40 to 3.26	0.54 -4.94 to 5.83	0.55 -10.41 to 11.36	-0.00 -6.08 to 6.15	GLIMEPIRIDE	-0.14 -3.01 to 2.82	-0.24 -3.31 to 2.65	-0.33 -3.44 to 2.95	-0.65 -3.54 to 2.11	-0.85 -10.59 to 9.36	-0.83 -3.28 to 1.61	-2.03 -11.99 to 8.05	-2.43 -6.26 to 1.41	-2.49 -7.31 to 2.22	-2.89 -10.08 to 4.32	-3.23 -8.12 to 1.48	-3.92 -10.60 to 2.86
SEMA_PO_3MG_QD	-0.61 -2.27 to 1.08	7.03 2.85 to 11.33	6.83 0.91 to 12.75	5.33 1.01 to 9.58	5.14 1.73 to 8.53	5.02 1.17 to 9.00	4.25 1.02 to 7.49	3.56 1.65 to 5.47	3.24 -1.71 to 8.33	2.92 0.71 to 5.14	2.79 0.74 to 4.84	2.75 -0.48 to 5.91	2.73 -3.17 to 8.57	2.57 -0.70 to 5.87	2.49 0.42 to 4.62	2.17 -0.04 to 4.39	2.09 -0.40 to 4.60	2.06 -0.06 to 4.16	2.02 -0.59 to 4.65	1.96 -3.03 to 7.01	1.86 -1.37 to 5.17	1.87 -0.15 to 3.79	1.79 -0.65 to 4.16	1.68 -1.00 to 4.39	1.67 -0.79 to 4.07	1.64 -3.45 to 6.75	1.46 -0.71 to 3.59	1.09 -0.90 to 3.07	0.70 -4.48 to 5.78	0.62 -10.06 to 11.24	0.17 -5.88 to 6.08	0.14 -2.82 to 3.01	SEMA_PO_3MG_QD	-0.15 -2.51 to 2.22	-0.17 -3.08 to 2.81	-0.52 -2.97 to 1.84	-0.68 -10.37 to 9.52	-0.66 -2.74 to 1.34	-1.98 -11.61 to 8.14	-2.28 -5.70 to 1.23	-2.36 -6.83 to 2.10	-2.76 -9.87 to 4.33	-3.12 -7.81 to 1.32	-3.83 -10.22 to 2.68
ALBI_SC_FLEX_30-50_QW	-0.49 -2.20 to 1.28	7.20 3.10 to 11.35	6.94 1.11 to 12.89	5.48 1.10 to 9.81	5.32 1.96 to 8.64	5.17 1.32 to 9.11	4.37 1.18 to 7.63	3.68 1.23 to 6.12	3.34 -1.72 to 8.33	3.05 0.79 to 5.34	2.93 0.86 to 4.98	2.89 -0.38 to 6.05	2.84 -3.07 to 8.71	2.72 -0.60 to 5.88	2.62 0.04 to 5.24	2.30 0.14 to 4.63	2.18 -0.23 to 4.81	2.19 -0.01 to 4.35	2.16 -0.54 to 4.77	2.08 -2.90 to 7.06	2.02 -1.27 to 5.28	1.98 0.02 to 4.02	1.90 -0.55 to 4.33	1.83 -0.91 to 4.59	1.80 -0.75 to 4.18	1.78 -3.34 to 6.82	1.58 -0.60 to 3.77	1.20 -0.80 to 3.29	0.78 -4.34 to 5.92	0.70 -10.09 to 11.54	0.29 -5.61 to 6.29	0.24 -2.65 to 3.31	0.15 -2.22 to 2.51	ALBI_SC_FLEX_30-50_QW	-0.06 -2.87 to 2.98	-0.37 -2.84 to 1.99	-0.55 -10.14 to 9.63	-0.55 -2.63 to 1.54	-1.82 -11.41 to 8.27	-2.17 -5.49 to 1.35	-2.21 -6.67 to 2.21	-2.62 -9.74 to 4.34	-3.00 -7.48 to 1.48	-3.65 -10.11 to 2.82
INS_DEGLUDEC	-0.43 -2.91 to 1.89	7.20 2.80 to 11.56	6.99 0.95 to 12.95	5.51 0.93 to 10.05	5.31 1.76 to 8.85	5.18 1.05 to 9.28	4.42 0.92 to 7.86	3.75 0.70 to 6.65	3.42 -1.76 to 8.55	3.09 0.44 to 5.67	2.96 0.66 to 5.14	2.93 -0.52 to 6.18	2.90 -3.34 to 8.94	2.74 -0.81 to 6.30	2.68 -0.53 to 5.78	2.34 -0.19 to 4.78	2.24 0.56 to 3.96	2.21 -0.19 to 4.57	2.19 -0.72 to 4.98	2.13 -3.11 to 7.36	2.06 -1.50 to 5.51	2.01 -0.36 to 4.34	1.93 -0.82 to 4.66	1.85 -1.11 to 4.81	1.83 -1.01 to 4.55	1.78 -3.47 to 7.09	1.61 -0.86 to 3.96	1.24 -1.19 to 3.58	0.86 -4.49 to 6.14	0.74 -10.11 to 11.72	0.31 -5.79 to 6.44	0.33 -2.95 to 3.44	0.17 -2.81 to 3.08	0.06 -2.98 to 2.87	INS_DEGLUDEC	-0.35 -3.05 to 2.23	-0.57 -10.28 to 9.68	-0.50 -2.71 to 1.59	-1.73 -11.68 to 8.50	-2.12 -5.89 to 1.63	-2.18 -6.92 to 2.42	-2.59 -9.71 to 4.46	-2.99 -7.70 to 1.74	-3.66 -10.37 to 3.21
METFORMIN	-0.10 -1.80 to 1.72	7.57 3.92 to 11.30	7.34 1.59 to 13.23	5.86 1.63 to 10.11	5.67 2.64 to 8.86	5.55 2.28 to 8.98	4.77 1.82 to 7.77	4.09 1.63 to 6.50	3.77 -1.16 to 8.61	3.44 1.36 to 5.58	3.31 1.66 to 4.97	3.27 0.31 to 6.26	3.27 -2.74 to 9.23	3.09 0.01 to 6.29	3.02 0.37 to 5.60	2.71 0.67 to 4.74	2.61 0.41 to 4.87	2.57 0.90 to 4.28	2.54 0.16 to 5.03	2.50 -2.38 to 7.39	2.39 -0.70 to 5.69	2.36 0.67 to 4.08	2.29 0.01 to 4.66	2.21 0.05 to 4.46	2.20 -0.04 to 4.45	2.16 -2.75 to 7.25	1.97 0.25 to 3.72	1.59 -0.07 to 3.34	1.22 -3.95 to 6.27	1.21 -9.61 to 11.92	0.67 -5.10 to 6.64	0.65 -2.11 to 3.54	0.52 -1.84 to 2.97	0.37 -1.99 to 2.84	0.35 -2.23 to 3.05	METFORMIN	-0.15 -9.82 to 9.79	-0.15 -1.88 to 1.65	-1.42 -10.99 to 8.66	-1.77 -5.05 to 1.67	-1.82 -6.16 to 2.52	-2.21 -9.17 to 4.60	-2.61 -6.99 to 1.85	-3.25 -9.86 to 3.32
PEGLOX_SC_400UG_QW	0.06 -9.89 to 9.59	7.74 -2.78 to 17.98	7.51 -4.04 to 18.72	6.06 -4.49 to 16.24	5.83 -4.44 to 15.85	5.72 -4.72 to 15.72	4.88 -5.34 to 14.71	4.24 -5.94 to 13.97	3.92 -6.92 to 14.44	3.60 -6.46 to 13.22	3.45 -6.49 to 12.96	3.45 -6.79 to 13.16	3.31 -7.92 to 14.55	3.28 -6.98 to 13.05	3.16 -7.06 to 13.05	2.91 -7.04 to 12.42	2.79 -7.30 to 12.22	2.75 -7.27 to 12.39	2.71 -7.41 to 12.35	2.58 -8.15 to 12.88	2.51 -7.74 to 12.55	2.54 -7.50 to 11.97	2.46 -7.64 to 12.06	2.42 -7.78 to 12.15	2.36 -7.90 to 11.91	2.27 -8.71 to 12.86	2.12 -7.87 to 11.75	1.80 -8.22 to 11.25	1.40 -9.46 to 11.80	1.25 -13.39 to 15.48	0.89 -10.52 to 12.04	0.85 -9.36 to 10.59	0.68 -9.52 to 10.37	0.55 -9.63 to 10.14	0.57 -9.68 to 10.28	0.15 -9.79 to 9.82	PEGLOX_SC_400UG_QW	0.04 -9.99 to 9.50	-1.15 -11.02 to 8.65	-1.60 -11.87 to 8.50	-1.71 -12.38 to 8.69	-2.12 -14.36 to 9.64	-2.43 -13.46 to 7.88	-3.14 -14.81 to 8.54
INS_GLARGINE	0.07 -1.15 to 1.31	7.73 3.84 to 11.57	7.47 1.78 to 13.15	6.02 1.99 to 10.02	5.84 2.87 to 8.78	5.67 2.16 to 9.34	4.92 2.12 to 7.75	4.22 2.10 to 6.35	3.92 -0.88 to 8.63	3.59 2.00 to 5.17	3.46 2.27 to 4.66	3.41 0.62 to 6.10	3.39 -2.42 to 9.17	3.25 0.33 to 6.13	3.17 0.84 to 5.46	2.85 1.30 to 4.41	2.75 1.30 to 4.30	2.73 1.43 to 4.01	2.70 0.64 to 4.75	2.63 -2.16 to 7.43	2.55 -0.32 to 5.47	2.52 1.37 to 3.64	2.44 0.65 to 4.25	2.36 0.26 to 4.49	2.34 0.40 to 4.21	2.28 -2.52 to 7.19	2.12 0.66 to 3.54	1.75 0.56 to 2.89	1.33 -3.60 to 6.18	1.29 -9.41 to 11.96	0.84 -4.88 to 6.63	0.83 -1.61 to 3.28	0.66 -1.34 to 2.74	0.55 -1.54 to 2.63	0.50 -1.59 to 2.71	0.15 -1.65 to 1.88	-0.04 -9.50 to 9.99	INS_GLARGINE	-1.28 -10.92 to 8.71	-1.61 -4.64 to 1.50	-1.66 -5.87 to 2.54	-2.06 -8.97 to 4.75	-2.43 -6.82 to 1.80	-3.11 -9.52 to 3.28
PEGLOX_SC_300UG_QW	1.34 -8.59 to 10.82	8.99 -1.69 to 19.20	8.79 -2.62 to 19.69	7.27 -3.30 to 17.47	7.10 -3.28 to 17.10	6.93 -3.38 to 17.14	6.16 -3.95 to 15.84	5.52 -4.57 to 15.06	5.10 -5.86 to 15.73	4.85 -5.19 to 14.55	4.75 -5.32 to 14.26	4.75 -5.64 to 14.52	4.59 -6.71 to 15.78	4.48 -5.71 to 14.38	4.48 -5.65 to 14.12	4.10 -6.01 to 13.71	4.02 -6.16 to 13.68	4.01 -6.07 to 13.69	4.00 -6.19 to 13.68	3.87 -7.32 to 14.73	3.81 -6.45 to 13.73	3.84 -6.19 to 13.28	3.70 -6.41 to 13.37	3.60 -6.55 to 13.49	3.63 -6.43 to 13.22	3.64 -7.50 to 14.09	3.39 -6.57 to 12.89	3.04 -6.90 to 12.50	2.58 -8.41 to 13.08	2.56 -12.25 to 16.83	2.06 -9.55 to 13.14	2.03 -8.05 to 11.99	1.98 -8.14 to 11.61	1.82 -8.27 to 11.41	1.73 -8.50 to 11.68	1.42 -8.66 to 10.99	1.15 -8.65 to 11.02	1.28 -8.71 to 10.92	PEGLOX_SC_300UG_QW	-0.32 -10.90 to 9.76	-0.42 -11.34 to 9.89	-0.85 -12.97 to 10.83	-1.18 -12.11 to 9.19	-1.93 -13.66 to 9.48
INS_LISPRO	1.69 -1.39 to 4.72	9.33 4.58 to 14.09	9.09 2.85 to 15.42	7.65 2.68 to 12.46	7.47 3.37 to 11.38	7.31 2.77 to 11.85	6.52 2.51 to 10.42	5.86 2.26 to 9.25	5.52 -0.02 to 11.08	5.21 1.90 to 8.51	5.09 1.97 to 8.12	5.04 1.08 to 8.80	5.03 -1.37 to 11.28	4.87 0.79 to 8.90	4.78 1.09 to 8.41	4.44 1.75 to 7.11	4.37 0.92 to 7.72	4.35 1.23 to 7.39	4.30 0.72 to 7.88	4.23 -1.34 to 9.84	4.18 0.10 to 8.19	4.13 1.05 to 7.12	4.04 0.65 to 7.47	3.99 0.38 to 7.45	3.95 0.43 to 7.27	3.87 -1.72 to 9.51	3.73 0.49 to 6.81	3.37 0.29 to 6.37	2.94 -2.77 to 8.61	2.92 -8.10 to 13.87	2.43 -3.78 to 8.63	2.43 -1.41 to 6.26	2.28 -1.23 to 5.70	2.17 -1.35 to 5.49	2.12 -1.63 to 5.89	1.77 -1.67 to 5.05	1.60 -8.50 to 11.87	1.61 -1.50 to 4.64	0.32 -9.76 to 10.90	INS_LISPRO	-0.06 -5.04 to 4.98	-0.44 -7.96 to 6.83	-0.85 -5.50 to 3.59	-1.57 -8.56 to 5.46
INS_DETEMIR	1.73 -2.43 to 6.00	9.40 4.00 to 14.99	9.24 2.21 to 16.03	7.69 2.14 to 13.45	7.54 2.78 to 12.27	7.42 2.11 to 12.81	6.60 1.66 to 11.51	5.90 1.39 to 10.38	5.54 -0.57 to 11.92	5.27 0.91 to 9.69	5.12 1.04 to 9.34	5.09 0.48 to 9.90	5.07 -1.96 to 12.06	4.93 -0.00 to 9.88	4.82 0.26 to 9.39	4.52 0.30 to 8.89	4.42 0.12 to 8.86	4.41 0.42 to 8.48	4.36 -0.13 to 8.82	4.32 -2.01 to 10.57	4.22 -0.64 to 9.11	4.20 -0.02 to 8.45	4.12 -0.33 to 8.66	4.06 -0.37 to 8.44	3.98 -0.48 to 8.49	4.01 -2.47 to 10.44	3.78 -0.43 to 8.01	3.44 -0.83 to 7.69	3.02 -3.53 to 9.37	3.02 -8.62 to 14.19	2.54 -4.44 to 9.47	2.49 -2.22 to 7.31	2.36 -2.10 to 6.83	2.21 -2.21 to 6.67	2.18 -2.42 to 6.92	1.82 -2.52 to 6.16	1.71 -8.69 to 12.38	1.66 -2.54 to 5.87	0.42 -9.89 to 11.34	0.06 -4.98 to 5.04	INS_DETEMIR	-0.40 -8.34 to 7.56	-0.77 -6.75 to 5.16	-1.43 -9.01 to 6.19
GLICLAZIDE	2.14 -4.70 to 9.03	9.82 2.32 to 17.46	9.59 0.67 to 18.49	8.14 0.20 to 16.01	7.93 0.72 to 15.07	7.79 0.35 to 15.37	7.02 -0.21 to 14.31	6.33 -0.73 to 13.47	5.96 -2.03 to 14.41	5.65 -1.23 to 12.69	5.53 -1.27 to 12.34	5.53 -1.59 to 12.78	5.41 -3.09 to 14.64	5.33 -2.07 to 12.67	5.22 -1.92 to 12.47	4.94 -1.94 to 11.89	4.83 -2.18 to 11.81	4.82 -2.04 to 11.59	4.74 -2.23 to 11.85	4.66 -3.63 to 13.13	4.58 -2.68 to 12.13	4.60 -2.21 to 11.43	4.48 -2.49 to 11.53	4.45 -2.57 to 11.30	4.44 -2.54 to 11.45	4.40 -4.02 to 12.92	4.20 -2.65 to 11.03	3.81 -3.05 to 10.82	3.43 -4.73 to 11.81	3.45 -9.29 to 15.94	2.92 -5.70 to 11.74	2.89 -4.32 to 10.08	2.76 -4.33 to 9.87	2.62 -4.34 to 9.74	2.59 -4.46 to 9.71	2.21 -4.60 to 9.17	2.12 -9.64 to 14.36	2.06 -4.75 to 8.97	0.85 -10.83 to 12.97	0.44 -6.83 to 7.96	0.40 -7.56 to 8.34	GLICLAZIDE	-0.33 -8.28 to 7.57	-0.99 -10.49 to 8.36
STANDARD_CARE	2.51 -1.70 to 6.78	10.16 4.61 to 15.79	9.95 3.05 to 16.89	8.43 2.70 to 14.08	8.28 3.32 to 13.25	8.16 2.79 to 13.56	7.37 2.34 to 12.26	6.69 2.14 to 11.27	6.38 -0.06 to 12.66	6.06 1.65 to 10.39	5.90 1.73 to 10.15	5.87 1.01 to 10.74	5.80 -1.28 to 12.80	5.71 0.71 to 10.72	5.63 0.96 to 10.32	5.29 1.18 to 9.50	5.21 0.77 to 9.75	5.15 1.01 to 9.50	5.15 0.54 to 9.76	5.02 -1.17 to 11.54	5.03 -0.02 to 10.07	4.99 0.74 to 9.27	4.91 0.39 to 9.33	4.83 0.29 to 9.44	4.79 0.31 to 9.31	4.76 -1.55 to 11.32	4.55 0.27 to 8.92	4.19 -0.00 to 8.46	3.75 -2.61 to 10.17	3.86 -7.75 to 15.23	3.30 -3.56 to 10.11	3.23 -1.48 to 8.12	3.12 -1.32 to 7.81	3.00 -1.48 to 7.48	2.99 -1.74 to 7.70	2.61 -1.85 to 6.99	2.43 -7.88 to 13.46	2.43 -1.80 to 6.82	1.18 -9.19 to 12.11	0.85 -3.59 to 5.50	0.77 -5.16 to 6.75	0.33 -7.57 to 8.28	STANDARD_CARE	-0.70 -8.39 to 7.04
LIXI_SC_20UG_QD	3.17 -3.09 to 9.47	10.87 3.60 to 18.16	10.69 2.08 to 19.20	9.18 1.59 to 16.64	8.96 1.96 to 15.97	8.89 1.60 to 16.07	8.08 1.00 to 14.83	7.34 0.77 to 13.86	7.12 -0.98 to 14.89	6.71 0.16 to 13.14	6.59 0.01 to 12.97	6.54 -0.38 to 13.31	6.51 -2.11 to 15.13	6.38 -0.57 to 13.45	6.26 -0.29 to 12.78	6.01 -0.61 to 12.44	5.88 -0.74 to 12.41	5.87 -0.64 to 12.20	5.84 -0.98 to 12.49	5.79 -2.19 to 13.60	5.68 -1.18 to 12.59	5.65 -0.79 to 12.04	5.54 -1.08 to 11.99	5.49 -1.16 to 12.05	5.46 -1.21 to 12.01	5.47 -2.54 to 13.11	5.21 -1.20 to 11.73	4.92 -1.59 to 11.30	4.47 -3.43 to 12.27	4.46 -8.02 to 17.37	4.02 -4.66 to 12.54	3.92 -2.86 to 10.60	3.83 -2.68 to 10.22	3.65 -2.82 to 10.11	3.66 -3.21 to 10.37	3.25 -3.32 to 9.86	3.14 -8.54 to 14.81	3.11 -3.28 to 9.52	1.93 -9.48 to 13.66	1.57 -5.46 to 8.56	1.43 -6.19 to 9.01	0.99 -8.36 to 10.49	0.70 -7.04 to 8.39	LIXI_SC_20UG_QD

Heterogeneity, fit and convergence

Bayesian random effects (primary)

Heterogeneity (tau): 0.664 (95% CrI 0.051 to 1.306)
Residual deviance: 177.2 for 167 data points
DIC: 294.1 (pD 116.9)
Largest R-hat: 1.005
Smallest ESS: bulk 712, tail 1,503
Divergent transitions: 0
Convergence: All criteria met
Priors: PR01 N(0, 60^2); PR03 N(0, 30^2); PR07 half normal(0, 6^2) on tau

Frequentist check (netmeta)

Method: inverse variance, REML, MD
Tau: 0.833
I squared: 27%
Q (total): 84.67 on 62.0000000000001 df, P = 0.029
Q (between designs): 52.53, P = 0.177

Inconsistency

Do trials comparing two treatments directly agree with the indirect evidence through other treatments?

No comparison here has both direct and indirect evidence, so inconsistency cannot be checked by node splitting; the between designs Q above is the global check.

Small study effects

A comparison adjusted funnel plot: each point is one trial comparison, centered on its own network estimate. Asymmetry can signal that small trials with unfavorable results are missing.

Fewer than ten trial comparisons, too few to judge funnel plot asymmetry.

Baseline characteristics of the trials

The baseline value of each effect modifier or prognostic factor that applies here, per trial: mean or percent over arms, weighted by the number randomized. A note under a value names a stand in (a median for a mean, 100 minus the male share, Asian subgroup rows, an all Asian site list); "not reported" means no source of the trial prints it.

Baseline effect modifiers and prognostic factors per trial
Trial	Baseline BMI or body weight (kg/m2) effect modifier, prognostic factor; 58 of 67
NCT03131687 S000010	32.57
NCT00754988 S000027	32.47
NCT03068065 S000048	27.46
NCT01296412 S000080	32.65
DUAL™ I China S000081	26.75
MAGNA VICTORIA S000142	29.44
AWARD-10 S000305	32.68
NCT00765817 S000345	33.47
NCT01029886 S000352	32.3
NCT03010683 S000389	30.3
NCT00637273 S000402	32.33
SUSTAIN 9 S000483	31.9
SUSTAIN 10 S000584	body weight 96.9 kg
NCT00960661 S000609	32.5
NCT00935532 S000632	body weight 70.5 kg
NCT02008682 S000650	27.25
PREVAIL S000693	32.3
NCT01149421 S000784	32.96
NCT02229396 S000791	32.73
NCT01558271 S000837	25.51
SUSTAIN™1 S000878	33.2
NCT01617434 S000926	32.25
AWARD-CHN1 S001064	25.9
AWARD-8 S001068	31.2
NCT02465515 S001074	32.3
LIRA-SWITCH™ S001119	31.95
AWARD-2 S001130	31.55
DUAL™ VIII S001131	not reported
DURATION-NEO-2 S001157	31.83
AWARD-6 S001184	33.56
NCT00701935 S001193	not reported
NCT01191268 S001198	32.49
SUSTAIN™ 4 S001219	33
DUALTM IX S001236	31.2
NCT00877890 S001308	body weight 95.7 kg
NCT00360334 S001323	34.15
NCT01003184 S001355	33.7
AWARD-CHN2 S001404	26.77
NCT00917267 S001437	26.55
LIGHT-ON S001525	29.8
DUAL™ II China S001556	27.33
PIONEER 1 S001741	not reported
NCT00641056 S001768	32
ELEGANT S001780	33.04
NCT01126580 S001786	33.26
PIONEER 11 S001791	28.2
SUSTAIN™ 5 S001872	32.2
PIONEER 9 S001943	25.9
NCT00676338 S001966	31.21
PIONEER 5 S002025	body weight 90.8 kg
DUAL™ II Japan S002038	27.7
LEAD-5 S002098	30.54
NCT05990374 S002108	26.55
AWARD-1 S002153	33.16
NCT02505334 S002164	27.27
NCT00700817 S002361	32.77
PIONEER 8 S002369	not reported
S002858 S002858	body weight 102.0 kg
S002904 S002904	25.65 median
S002928 S002928	53.83 median
S002969 S002969	36.76 median
S003009 S003009	26.35
S003036 S003036	25.62
S003044 S003044	23.74
S003068 S003068	27.96
S003108 S003108	29.66
S003152 S003152	29.9

Comparability of the trials

Checked across designs (the set of treatments each trial compares) for eligibility, outcome definition and assessment, and the baseline factors above. Flags point to possible intransitivity; notes describe variation that is not tied to design.

FlagBaseline, Baseline BMI or body weight: design means range from 23.7 (EXEN_SC_10UG_BID vs INS_PREMIX) to 53.8 (PEGLOX_SC_300UG_QW vs PEGLOX_SC_400UG_QW vs PLACEBO) kg/m2; threshold 3
FlagEligibility, bmi entry range: a design requires bmi 50 or more while another admits only 35 or less
NoteOutcome assessment, time point: selected time points span 20 to 34.76 weeks
NoteOutcome assessment, analysis set: mixed: completers 9, full_analysis 24, modified_itt 23, other 1, per_protocol 1, randomized 5, safety 4
NoteOutcome assessment, definition: mixed: change in HbA1c from baseline 1, end of study HbA1c, back transformed geometric least squares mean adjusted for baseline 1, HbA1c after 24 weeks 1, LS mean systolic blood pressure change baseline to week 24 1, not stated 61, Observed HbA1c at visit, mean and SD 1, seated systolic blood pressure 1
NoteOutcome assessment, intercurrent events (discontinuation): mixed: hypothetical 3, not stated 63, treatment_policy 1
NoteOutcome assessment, intercurrent events (rescue): mixed: hypothetical 6, not stated 61
NoteRisk of bias, blinding: mixed: double_blind 32, not_reported 1, open_label 31, single_blind 3
NoteRisk of bias, funding: mixed: industry 54, mixed 4, non_industry 7, not_reported 2
NoteData handling, input conversions: median_converted 5, n_randomized 10

Comparability items per trial
Trial	time weeks	analysis set	definition	instrument	adjudicated	proportion method	intercurrent events (discontinuation)	funding	intercurrent events (rescue)	blinding	start year	Eligibility
NCT03131687	26	safety	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2017	age 18 to 75; T2D at least 6 months; HbA1c 7.0 to 10.5%; BMI 23 to 50; diet and exercise or metformin
NCT00754988	24	modified_itt	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2008	age 18 to 75; HbA1c 7.0 to 10.0 percent; BMI 25 (23 Asian) to 45; metformin at least 1500 mg
NCT03068065	24	completers	not stated	not stated	not stated	not stated	not stated	not_reported	not stated	open_label	2014	age 18 to 70; drug naive 3 months; HbA1c 7 to 14 percent; BMI 20 to 38; NAFLD on ultrasound
NCT01296412	26	completers	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2011	age 18 to 79; HbA1c 7.0 to 11.0 percent on metformin 1500 mg or more; eGFR 60 or more
DUAL™ I China	26	full_analysis	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2017	Chinese adults 18 y or older; HbA1c 7.0 to 10.0; BMI 40 or less; metformin with or without one OAD
MAGNA VICTORIA	26	modified_itt	not stated	not stated	not stated	not stated	not stated	mixed	not stated	double_blind	2015	South Asian descent; age 18 to 74; BMI 23 or more; HbA1c 6.5 to 11.0 percent
AWARD-10	24	modified_itt	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2015	T2D; HbA1c 7.0 to 9.5 percent; BMI 45 or lower; SGLT2i with or without metformin
NCT00765817	30	full_analysis	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2008	adults 18 or older; insulin glargine 20 U/d or more alone or with metformin or pioglitazone; HbA1c 7.1 to 10.5 percent; BMI 45 or less
NCT01029886	26	modified_itt	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2010	adults 18 or older with type 2 diabetes on oral agents, HbA1c 7.1 to 11.0 percent, BMI 45 or less
NCT03010683	26.07	randomized	not stated	not stated	not stated	not stated	not stated	not_reported	not stated	single_blind	2015	newly diagnosed treatment naive type 2 diabetes; no cardiovascular, liver or kidney disease
NCT00637273	26	modified_itt	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2008	age 18 or older; HbA1c 7.1 to 11.0 percent; BMI 25 to 45; stable metformin
SUSTAIN 9	30	full_analysis	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2017	adults 18 or older (20 in Japan); HbA1c 7.0 to 10.5 percent; stable SGLT2i with or without metformin or SU
SUSTAIN 10	30	full_analysis	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2017	adults with T2D, HbA1c 7.0 to 11.0 percent on 1 to 3 oral drugs
NCT00960661	30	per_protocol	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2009	age 18 or older; T2D on insulin glargine and metformin with or without sulfonylurea; HbA1c 7.0 to 10.0; BMI 25.0 (23.0 in South Korea) to 45.0; HbA1c above 7.0 after optimization
NCT00935532	26	full_analysis	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2009	type 2 diabetes on biguanide with or without thiazolidinedione
NCT02008682	26	full_analysis	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2013	Chinese adults 18 to 80; HbA1c 7.0 to 10.0 on metformin; BMI 45 or lower
PREVAIL	20	other	not stated	not stated	not stated	not stated	not stated	non_industry	not stated	open_label	2014	age 30 to 80; T2D 7 years or less; A1c 6.0 to 9.5 percent off drugs or 5.5 to 9.0 on up to 2 oral drugs
NCT01149421	26	modified_itt	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2010	adults 18 or older; HbA1c 7 to 9.5 percent; stable oral agents
NCT02229396	28	modified_itt	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2014	age 18 or older; HbA1c 8.0 to 12.0 percent on metformin 1500 mg/d or more
NCT01558271	26	safety	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2012	Japanese; age 20 or more; BMI 18.5 to 35; HbA1c 7.0 to 10.0 percent; OAM naive or OAM stopped
SUSTAIN™1	30	full_analysis	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2014	age 18 or older (20 in Japan); HbA1c 7.0 to 10.0 percent; drug naive on diet and exercise; eGFR 30 or more
NCT01617434	26	full_analysis	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2012	age 18 to 80; HbA1c 7.0 to 10.0 percent; BMI 20 to 45; basal insulin analogue 20 U or more with or without metformin
AWARD-CHN1	26	modified_itt	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2012	age 18 or older; BMI 19 to 35 kg/m2; HbA1c 7.0 to 10.5 percent OAM naive or 6.5 to 10.0 percent on OAM monotherapy
AWARD-8	24	modified_itt	seated systolic blood pressure	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2013	age 18 or older; BMI up to 45; HbA1c 7.5 to 9.5 percent on sulfonylurea at least half maximal dose
NCT02465515	34.76	randomized	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2015	type 2 diabetes with established cardiovascular disease
LIRA-SWITCH™	26	full_analysis	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2013	age 18 or more; HbA1c 7.5 to 9.5 percent; BMI 20 or more; on sitagliptin 100 mg and metformin for 90 days or more
AWARD-2	26	modified_itt	not stated	not stated	not stated	not stated	not stated	industry	hypothetical	open_label	2010	type 2 diabetes on metformin and glimepiride
DUAL™ VIII	26	full_analysis	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2016	adults with type 2 diabetes uncontrolled on oral drugs, insulin naive
DURATION-NEO-2	28	modified_itt	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2013	age 18 or older; HbA1c 7.1 to 11.0 percent; BMI 45 or lower; metformin 1500 mg or more
AWARD-6	26	modified_itt	change in HbA1c from baseline	not stated	not stated	not stated	not stated	industry	not stated	open_label	2012	adults; HbA1c 7 to 10 percent; metformin 1500 mg/day or more
NCT00701935	26.07	modified_itt	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2008	adults with T2D on metformin
NCT01191268	26	modified_itt	not stated	not stated	not stated	not stated	not stated	industry	hypothetical	open_label	2010	adults with type 2 diabetes on conventional insulin with or without metformin
SUSTAIN™ 4	30	full_analysis	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2014	adults with T2D, insulin naive, on metformin with or without SU; HbA1c 7.0 to 10.0 percent
DUALTM IX	26	full_analysis	not stated	not stated	not stated	not stated	treatment_policy	industry	not stated	open_label	2016	adults; insulin naive type 2 diabetes on SGLT2 inhibitor with or without other oral drugs; HbA1c 7.0 to 11.0 percent; BMI 20 to 40
NCT00877890	24	modified_itt	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2009	age 18 or older; HbA1c 7.1 to 11.0 percent; BMI 25 to 45
NCT00360334	26	full_analysis	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2006	BMI above 27; HbA1c 7.5 to 10.0 percent; 2 or 3 oral drugs; at least one CV risk factor
NCT01003184	26	modified_itt	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2009	age 18 or older; HbA1c 7.1 to 10.0 percent; BMI 25 to 45; metformin with or without SU
AWARD-CHN2	26	safety	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2012	age 18 or older; BMI 19 to 35 kg/m2; HbA1c 7.0 to 11.0 percent on metformin and/or sulfonylurea
NCT00917267	26	modified_itt	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2009	Asian adults 20 or older; HbA1c 7 to 11; BMI 21 to 35; on oral drugs
LIGHT-ON	26	randomized	not stated	not stated	not stated	not stated	not stated	mixed	not stated	open_label	2014	age 30 to 75, HbA1c 6.5 to 10 percent on metformin, NAFLD with MRI-PDFF over 10 percent, BMI 20 to 35
DUAL™ II China	26	full_analysis	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2017	age 18 or older; BMI 24 or higher; HbA1c 7.5 or higher; basal insulin 20 to 50 U plus metformin
PIONEER 1	26	full_analysis	not stated	not stated	not stated	not stated	hypothetical	industry	hypothetical	double_blind	2016	adults with type 2 diabetes on diet and exercise only; HbA1c 7.0 to 9.5 percent
NCT00641056	26	modified_itt	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2008	age 18 or older; HbA1c 7.1 to 11.0 percent; BMI 25 to 45; metformin with or without sulfonylurea
ELEGANT	26	randomized	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2012	age 18 to 75; BMI 25 or more; HbA1c 6.5 to 8.5 percent; insulin 3 to 16 months with 4 percent weight gain
NCT01126580	26	modified_itt	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2010	type 2 diabetes on diet and exercise or one oral drug; registry gives no ranges
PIONEER 11	26	safety	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2019	age 18 or older; HbA1c 7.0 to 10.0 percent at screening, 7.0 to 9.5 at randomization; no glucose lowering drugs; eGFR 60 or more
SUSTAIN™ 5	30	full_analysis	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2014	age 18 or older (20 in Japan); HbA1c 7.0 to 10.0 percent; stable basal insulin with or without metformin; eGFR 30 or more
PIONEER 9	26	full_analysis	not stated	not stated	not stated	not stated	hypothetical	industry	hypothetical	double_blind	2017	Japanese adults 20 y or older; HbA1c 6.5 to 9.5 on one oral drug washed out, or 7.0 to 10.0 on diet and exercise
NCT00676338	26	full_analysis	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2008	adults, HbA1c 7.1 to 11.0 percent, BMI 23 to 45 kg/m2, drug naive
PIONEER 5	26	full_analysis	not stated	not stated	not stated	not stated	hypothetical	industry	hypothetical	double_blind	2016	type 2 diabetes; HbA1c 7.0 to 9.5 percent; moderate renal impairment
DUAL™ II Japan	26	full_analysis	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2016	Japanese adults; BMI 23 kg/m2 or more; HbA1c 7.5 to 11.0 percent; basal or premix insulin 20 to 50 U with metformin
LEAD-5	26	modified_itt	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2006	age 18 to 80; HbA1c 7.5 to 10 on monotherapy or 7 to 10 on combination; BMI 45 or lower
NCT05990374	24	completers	not stated	not stated	not stated	not stated	not stated	non_industry	not stated	double_blind	2023	age 18 to 70; BMI 20 to 40; HbA1c 7.0 to 11.0; drug naive or stable metformin
AWARD-1	26	modified_itt	not stated	not stated	not stated	not stated	not stated	industry	hypothetical	double_blind	2010	adults with type 2 diabetes on metformin and pioglitazone
NCT02505334	26	full_analysis	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2015	Japanese adults on one oral drug, HbA1c 7.5 to 10.0 percent; randomized if HbA1c 7.0 or more after run in
NCT00700817	26	full_analysis	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2008	age 18 to 80; HbA1c 7.5 to 10%; BMI 45 or less; metformin 1500 mg/day or more for 3 months
PIONEER 8	26	full_analysis	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2017	adults with type 2 diabetes on basal, premixed or basal bolus insulin with or without metformin
S002858	24	modified_itt	end of study HbA1c, back transformed geometric least squares mean adjusted for baseline	not stated	not stated	not stated	not stated	industry	not stated	double_blind		T2D age over 35; clinical CKD; eGFR above 30 mL/min; stable ACE inhibitor or ARB
S002904	24	full_analysis	not stated	not stated	not stated	not stated	not stated	mixed	not stated	open_label	2014	age 20 or older; HbA1c 8.0 percent or more; diet or oral drugs; no insulin or GLP-1 RA
S002928	24	completers	LS mean systolic blood pressure change baseline to week 24	not stated	not stated	not stated	not stated	non_industry	not stated	single_blind	2022	age 18 to 65; BMI 50 or more; type 2 diabetes
S002969	26.07	modified_itt	not stated	not stated	not stated	not stated	not stated	industry	not stated	double_blind	2018	age 18 to 70; BMI 30 to 50; HbA1c 48 to below 97 mmol/mol; T2DM under 10 years; undergoing LAGB
S003009	24	completers	not stated	not stated	not stated	not stated	not stated	industry	not stated	open_label	2023	age 18 or more; HbA1c 7.0 to 10.0 percent; eGFR 30 to 90; UACR above 30 to 5000 mg/g
S003036	24	completers	not stated	not stated	not stated	not stated	not stated	non_industry	not stated	open_label	2022	age 20 or more; HbA1c 7.0 percent or more; DPP-4 inhibitor for 12 weeks or more
S003044	24	completers	HbA1c after 24 weeks	not stated	not stated	not stated	not stated	mixed	not stated	not_reported	2015	HbA1c 7.0 to <10.0%; BMI 18.5 to <25; waist >85 cm men, >80 cm women; stable oral agents
S003068	24	completers	Observed HbA1c at visit, mean and SD	not stated	not stated	not stated	not stated	non_industry	not stated	open_label		insulin treated T2D, age over 20, BMI 25 or more, HbA1c 7 to 10%
S003108	24	randomized	not stated	not stated	not stated	not stated	not stated	non_industry	not stated	single_blind	2012	T2D with coronary artery disease; no severe heart failure; creatinine up to 150 umol/L
S003152	24	completers	not stated	not stated	not stated	not stated	not stated	non_industry	not stated	open_label	2019	age 18 or more; BMI 24 or more; HbA1c 7.0 percent or more; metformin 1500 mg/d or more alone or with premixed insulin

Trial data

What each trial contributes. Arm rows give the arm value with its standard error, or events over participants; contrast rows give the mean difference on the analysis scale against the trial's first row. Flags mark converted, combined or approximated inputs.

Trial data entering this analysis
Trial	Arm	Treatment	Week	Data	Value	SE	Events / N	Flags	Source
NCT03131687	A1	PLACEBO	26	arm, change	1.700	1.980	51	n_randomized	R0016215:Supplement Table 2
NCT03131687	A2	TIRZ_SC_1MG_QW	26	arm, change	0.000	1.960	53	n_randomized	R0016215:Supplement Table 2
NCT03131687	A3	TIRZ_SC_5MG_QW	26	arm, change	-2.600	1.860	55	n_randomized	R0016215:Supplement Table 2
NCT03131687	A4	TIRZ_SC_10MG_QW	26	arm, change	-1.300	1.920	52	n_randomized	R0016215:Supplement Table 2
NCT03131687	A5	TIRZ_SC_15MG_QW	26	arm, change	-1.000	2.000	53	n_randomized	R0016215:Supplement Table 2
NCT03131687	A6	DULA_SC_1p5MG_QW	26	arm, change	-1.500	1.890	54	n_randomized	R0016215:Supplement Table 2
NCT00754988	A1	PLACEBO	24	arm, change	-0.900	1.278	90		R0022521:Table 5
NCT00754988	A2	TASP_SC_10MG_QW	24	arm, change	-4.000	0.916	182		R0022521:Table 5
NCT00754988	A3	TASP_SC_20MG_QW	24	arm, change	-3.300	0.906	187		R0022521:Table 5
NCT00754988	A4	SITAGLIPTIN	24	arm, change	-2.800	0.929	177		R0022521:Table 5
NCT03068065	A1	LIRA_SC_1p8MG_QD	24	arm, final	107.000	2.000	29		R0025051:Table 2
NCT03068065	A2	METFORMIN	24	arm, final	112.000	3.000	29		R0025051:Table 2
NCT03068065	A3	GLICLAZIDE	24	arm, final	113.000	3.000	27		R0025051:Table 2
NCT01296412	A1	SITAGLIPTIN	26	arm, change	0.900	0.689	285		R0026295:Table 4
NCT01296412	A2	LIRA_SC_FLEX_1p2-1p8_QD	26	arm, change	-1.900	0.714	262		R0026295:Table 4
DUAL™ I China	A1	IDEGLIRA_SC_TIT_QD	26	arm, change	-3.500	0.688	341		registry:outcomes
DUAL™ I China	A2	INS_DEGLUDEC	26	arm, change	-1.200	0.905	167		registry:outcomes
DUAL™ I China	A3	LIRA_SC_1p8MG_QD	26	arm, change	-3.300	1.123	151		registry:outcomes
MAGNA VICTORIA	A1	LIRA_SC_1p8MG_QD	26	arm, change	-14.000	3.838	22	n_randomized	R0021697:Results
MAGNA VICTORIA	A2	PLACEBO	26	arm, change	-7.000	3.000	25	n_randomized	R0021697:Results
AWARD-10	A1	DULA_SC_1p5MG_QW	24	contrast, md	-3.300	1.454			R0008191:Supplement Table S4
AWARD-10	A3	PLACEBO	24	contrast, md					R0008191:Supplement Table S4
NCT00765817	A1	EXEN_SC_10UG_BID	30	arm, change	-2.700	1.250	137		R0027069:Table 2
NCT00765817	A2	PLACEBO	30	arm, change	1.700	1.327	122		R0027069:Table 2
NCT01029886	A1	EXENER_SC_2MG_QW	26	arm, change	-2.480	0.560	404		R0016299:Table 2
NCT01029886	A2	LIRA_SC_1p8MG_QD	26	arm, change	-3.450	0.570	398		R0016299:Table 2
NCT03010683	A1	LIRA_SC_1p8MG_QD	26.07	arm, final	138.000	3.469	30		R0016601:Table 2
NCT03010683	A2	METFORMIN	26.07	arm, final	141.000	2.921	30		R0016601:Table 2
NCT00637273	A1	EXENER_SC_2MG_QW	26	arm, change	-3.600	0.970	160		registry:outcomes
NCT00637273	A2	SITAGLIPTIN	26	arm, change	0.200	0.950	163		registry:outcomes
NCT00637273	A3	PIOGLITAZONE	26	arm, change	-1.600	0.950	165		registry:outcomes
SUSTAIN 9	A1	SEMA_SC_1p0MG_QW	30	arm, change	-4.300	1.180	151		registry:outcomes
SUSTAIN 9	A2	PLACEBO	30	arm, change	1.100	1.001	151		registry:outcomes
SUSTAIN 10	A1	SEMA_SC_1p0MG_QW	30	arm, change	-4.300	0.787	290		registry:outcomes
SUSTAIN 10	A2	LIRA_SC_1p2MG_QD	30	arm, change	-3.700	0.815	287		registry:outcomes
NCT00960661	A1	EXEN_SC_10UG_BID	30	arm, change	-4.100	1.000	207		R0016788:Table 2
NCT00960661	A2	INS_LISPRO	30	arm, change	0.400	0.900	227		R0016788:Table 2
NCT00935532	A1	EXENER_SC_2MG_QW	26	arm, change	-4.500	0.960	214		registry:outcomes
NCT00935532	A2	INS_GLARGINE	26	arm, change	-2.600	0.981	212		registry:outcomes
NCT02008682	A1	LIRA_SC_1p8MG_QD	26	contrast, md	-1.550	1.171			R0025836:Supplement Table S1
NCT02008682	A2	SITAGLIPTIN	26	contrast, md					R0025836:Supplement Table S1
PREVAIL	A1	STANDARD_CARE	20	arm, final	133.000	2.100			R0009210:Table 3
PREVAIL	A2	INS_LISPRO	20	arm, final	132.000	2.000			R0009210:Table 3
PREVAIL	A3	EXEN_SC_10UG_BID	20	arm, final	128.000	1.900			R0009210:Table 3
NCT01149421	A1	DULA_SC_1p5MG_QW	26	arm, change	-2.510	0.630	247		registry:outcomes
NCT01149421	A2	DULA_SC_0p75MG_QW	26	arm, change	-1.560	0.600	251		registry:outcomes
NCT01149421	A3	PLACEBO	26	arm, change	0.150	0.620	249		registry:outcomes
NCT02229396	A1	DAPAEXEN_SC_2-10MG_QW	28	arm, change	-4.300	0.791	228		registry:outcomes
NCT02229396	A2	EXENER_SC_2MG_QW	28	arm, change	-1.200	0.816	227		registry:outcomes
NCT02229396	A3	DAPAGLIFLOZIN	28	arm, change	-1.800	0.791	230		registry:outcomes
NCT01558271	A1	DULA_SC_0p75MG_QW	26	arm, change	0.620	0.620	280		R0011901:Table 2
NCT01558271	A2	LIRA_SC_0p9MG_QD	26	arm, change	-2.100	0.890	136		R0011901:Table 2
NCT01558271	A3	PLACEBO	26	arm, change	0.530	1.250	70		R0011901:Table 2
SUSTAIN™1	A1	SEMA_SC_0p5MG_QW	30	arm, change	-2.290	1.112	128		registry:outcomes
SUSTAIN™1	A2	SEMA_SC_1p0MG_QW	30	arm, change	-2.740	1.016	130		registry:outcomes
SUSTAIN™1	A3	PLACEBO	30	arm, change	-2.010	0.989	129		registry:outcomes
NCT01617434	A1	LIRA_SC_1p8MG_QD	26	contrast, md	-5.020	1.240			R0026247:Table 2
NCT01617434	A2	PLACEBO	26	contrast, md					R0026247:Table 2
AWARD-CHN1	A1	DULA_SC_1p5MG_QW	26	arm, change	-2.070	0.815	222		registry:outcomes
AWARD-CHN1	A2	DULA_SC_0p75MG_QW	26	arm, change	-1.880	0.813	224		registry:outcomes
AWARD-CHN1	A3	GLIMEPIRIDE	26	arm, change	-0.660	0.804	231		registry:outcomes
AWARD-8	A1	DULA_SC_1p5MG_QW	24	arm, change	-0.520	0.960	240	n_randomized	R0016038:Table 2
AWARD-8	A2	PLACEBO	24	arm, change	0.000	1.540	60	n_randomized	R0016038:Table 2
NCT02465515	A1	PLACEBO	34.76	arm, change	-0.500	0.266	4,241		registry:outcomes
NCT02465515	A2	ALBI_SC_FLEX_30-50_QW	34.76	arm, change	-1.000	0.256	4,319		registry:outcomes
LIRA-SWITCH™	A1	LIRA_SC_1p8MG_QD	26	arm, change	-3.600	0.837	192		registry:outcomes
LIRA-SWITCH™	A2	SITAGLIPTIN	26	arm, change	-2.570	0.820	200		registry:outcomes
AWARD-2	A1	DULA_SC_1p5MG_QW	26	arm, change	-1.280	0.780	257		registry:outcomes
AWARD-2	A2	DULA_SC_0p75MG_QW	26	arm, change	-1.600	0.780	261		registry:outcomes
AWARD-2	A3	INS_GLARGINE	26	arm, change	-0.030	0.800	245		registry:outcomes
DUAL™ VIII	A1	IDEGLIRA_SC_TIT_QD	26	arm, change	-1.200	0.622	506		registry:outcomes
DUAL™ VIII	A2	INS_GLARGINE	26	arm, change	0.500	0.582	506		registry:outcomes
DURATION-NEO-2	A1	EXENER_SC_2MG_QW	28	arm, change	1.200	0.900	181		R0010641:Table 2
DURATION-NEO-2	A2	SITAGLIPTIN	28	arm, change	0.800	1.100	122		R0010641:Table 2
DURATION-NEO-2	A3	PLACEBO	28	arm, change	2.400	1.700	61		R0010641:Table 2
AWARD-6	A1	DULA_SC_1p5MG_QW	26	arm, change	-3.360	0.700	278		registry:outcomes
AWARD-6	A2	LIRA_SC_1p8MG_QD	26	arm, change	-2.820	0.700	281		registry:outcomes
NCT00701935	A1	EXEN_SC_10UG_BID	26.07	arm, change	-7.480	2.334	29		registry:outcomes
NCT00701935	A2	PLACEBO	26.07	arm, change	1.790	2.345	28		registry:outcomes
NCT01191268	A1	DULA_SC_1p5MG_QW	26	arm, change	-0.970	0.880	255		registry:outcomes
NCT01191268	A2	DULA_SC_0p75MG_QW	26	arm, change	-0.650	0.870	261		registry:outcomes
NCT01191268	A3	INS_GLARGINE	26	arm, change	2.230	0.880	258		registry:outcomes
SUSTAIN™ 4	A1	SEMA_SC_0p5MG_QW	30	arm, change	-4.650	0.720	362		registry:outcomes
SUSTAIN™ 4	A2	SEMA_SC_1p0MG_QW	30	arm, change	-5.170	0.730	360		registry:outcomes
SUSTAIN™ 4	A3	INS_GLARGINE	30	arm, change	-1.680	0.680	360		registry:outcomes
DUALTM IX	A1	IDEGLIRA_SC_TIT_QD	26	arm, change	-3.000	0.876	210		registry:outcomes
DUALTM IX	A2	INS_GLARGINE	26	arm, change	0.600	0.828	210		registry:outcomes
NCT00877890	A1	EXENER_SC_2MG_QW	24	arm, change	-2.900	1.130	128		registry:outcomes
NCT00877890	A2	EXEN_SC_10UG_BID	24	arm, change	-1.200	1.190	120		registry:outcomes
NCT00360334	A1	EXEN_SC_10UG_BID	26	arm, change	-2.900	1.200	117		R0024925:Table 2
NCT00360334	A2	INS_GLARGINE	26	arm, change	0.700	1.200	114		R0024925:Table 2
NCT01003184	A1	EXENER_SC_2MG_QW	26	arm, change	-6.800	1.327	111		R0027663:Table 1
NCT01003184	A2	INS_DETEMIR	26	arm, change	-2.400	1.352	105		R0027663:Table 1
AWARD-CHN2	A1	DULA_SC_1p5MG_QW	26	arm, change	-5.530	0.749	258		R0023722:Table 2
AWARD-CHN2	A2	DULA_SC_0p75MG_QW	26	arm, change	-2.770	0.744	257		R0023722:Table 2
AWARD-CHN2	A3	INS_GLARGINE	26	arm, change	-2.220	0.801	253		R0023722:Table 2
NCT00917267	A1	EXENER_SC_2MG_QW	26	arm, change	-5.410	0.820	340		R0026895:Table 1
NCT00917267	A2	EXEN_SC_10UG_BID	26	arm, change	-5.380	0.860	338		R0026895:Table 1
LIGHT-ON	A1	LIRA_SC_1p8MG_QD	26	arm, change	-3.500	1.755	24		R0024860:Table 2
LIGHT-ON	A2	SITAGLIPTIN	26	arm, change	-1.600	1.982	27		R0024860:Table 2
LIGHT-ON	A3	INS_GLARGINE	26	arm, change	0.600	2.266	24		R0024860:Table 2
DUAL™ II China	A1	IDEGLIRA_SC_TIT_QD	26	arm, change	-3.500	0.801	288		registry:outcomes
DUAL™ II China	A2	INS_DEGLUDEC	26	arm, change	-0.500	1.060	139		registry:outcomes
PIONEER 1	A1	SEMA_PO_3MG_QD	26	arm, change	-3.000	1.103	161		registry:outcomes
PIONEER 1	A2	SEMA_PO_7MG_QD	26	arm, change	-5.000	1.048	154		registry:outcomes
PIONEER 1	A3	SEMA_PO_14MG_QD	26	arm, change	-5.000	1.139	151		registry:outcomes
PIONEER 1	A4	PLACEBO	26	arm, change	-3.000	1.114	158		registry:outcomes
NCT00641056	A1	EXENER_SC_2MG_QW	26	arm, change	-3.030	1.086	233		registry:outcomes
NCT00641056	A2	INS_GLARGINE	26	arm, change	-0.630	0.999	222		registry:outcomes
ELEGANT	A1	LIRA_SC_1p8MG_QD	26	arm, change	-7.000	2.000	26		R0025175:Table 2
ELEGANT	A2	STANDARD_CARE	26	arm, change	-3.000	3.000	24		R0025175:Table 2
NCT01126580	A1	DULA_SC_1p5MG_QW	26	arm, change	-1.890	0.890	244		registry:outcomes
NCT01126580	A2	DULA_SC_0p75MG_QW	26	arm, change	-2.610	0.880	251		registry:outcomes
NCT01126580	A3	METFORMIN	26	arm, change	-0.910	0.890	239		registry:outcomes
PIONEER 11	A1	SEMA_PO_3MG_QD	26	contrast, md	2.000	1.531			R0019663:Supplement Table 7
PIONEER 11	A4	PLACEBO	26	contrast, md					R0019663:Supplement Table 7
SUSTAIN™ 5	A1	SEMA_SC_0p5MG_QW	30	arm, change	-4.290	1.260	132		registry:outcomes
SUSTAIN™ 5	A2	SEMA_SC_1p0MG_QW	30	arm, change	-7.270	1.270	131		registry:outcomes
SUSTAIN™ 5	A3	PLACEBO	30	arm, change	-0.990	1.340	133		registry:outcomes
PIONEER 9	A1	SEMA_PO_3MG_QD	26	arm, change	-3.000	1.857	49		registry:outcomes
PIONEER 9	A2	SEMA_PO_7MG_QD	26	arm, change	-5.000	1.714	49		registry:outcomes
PIONEER 9	A3	SEMA_PO_14MG_QD	26	arm, change	-2.000	1.732	48		registry:outcomes
PIONEER 9	A4	LIRA_SC_0p9MG_QD	26	arm, change	-1.000	1.876	48		registry:outcomes
PIONEER 9	A5	PLACEBO	26	arm, change	-4.000	1.571	49		registry:outcomes
NCT00676338	A1	EXENER_SC_2MG_QW	26	arm, change	-1.300	0.800	215		R0027761:Results
NCT00676338	A2	METFORMIN	26	arm, change	0.140	0.780	217		registry:outcomes
NCT00676338	A3	PIOGLITAZONE	26	arm, change	-1.700	1.000	134		R0027761:Results
NCT00676338	A4	SITAGLIPTIN	26	arm, change	-1.800	1.000	141		R0027761:Results
PIONEER 5	A1	SEMA_PO_14MG_QD	26	arm, change	-8.000	1.214	133		registry:outcomes
PIONEER 5	A2	PLACEBO	26	arm, change	0.000	1.095	141		registry:outcomes
DUAL™ II Japan	A1	IDEGLIRA_SC_TIT_QD	26	arm, change	-0.600	1.435	105		registry:outcomes
DUAL™ II Japan	A2	INS_DEGLUDEC	26	arm, change	0.900	1.327	105		registry:outcomes
LEAD-5	A1	LIRA_SC_1p8MG_QD	26	contrast, md	-4.510	1.179			R0027336:Results
LEAD-5	A3	INS_GLARGINE	26	contrast, md					R0027336:Results
NCT05990374	A1	EBENAT_SC_2MG_QW	24	arm, final	125.310	1.467	52		R0016638:Table 6
NCT05990374	A2	PLACEBO	24	arm, final	128.870	2.415	24		R0016638:Supplement Table 1
AWARD-1	A1	DULA_SC_1p5MG_QW	26	arm, change	0.110	0.830	263		registry:outcomes
AWARD-1	A2	DULA_SC_0p75MG_QW	26	arm, change	-0.360	0.820	266		registry:outcomes
AWARD-1	A3	EXEN_SC_10UG_BID	26	arm, change	0.060	0.830	259		registry:outcomes
AWARD-1	A4	PLACEBO	26	arm, change	3.400	1.130	127		registry:outcomes
NCT02505334	A1	LIRA_SC_1p8MG_QD	26	arm, change	-1.700	0.839	233		registry:outcomes
NCT02505334	A2	LIRA_SC_0p9MG_QD	26	arm, change	0.400	0.799	233		registry:outcomes
NCT00700817	A1	LIRA_SC_1p2MG_QD	26	arm, change	-0.550	0.890	213		registry:outcomes
NCT00700817	A2	LIRA_SC_1p8MG_QD	26	arm, change	-0.720	0.890	214		registry:outcomes
NCT00700817	A3	SITAGLIPTIN	26	arm, change	-0.940	0.890	213		registry:outcomes
PIONEER 8	A1	SEMA_PO_3MG_QD	26	arm, change	-1.000	0.885	184		registry:outcomes
PIONEER 8	A2	SEMA_PO_7MG_QD	26	arm, change	-3.000	1.264	181		registry:outcomes
PIONEER 8	A3	SEMA_PO_14MG_QD	26	arm, change	-5.000	1.041	181		registry:outcomes
PIONEER 8	A4	PLACEBO	26	arm, change	1.000	1.032	184		registry:outcomes
S002858	A1	LIXI_SC_20UG_QD	24	arm, final	136.600	2.194	47		R0001573:Table 2
S002858	A2	PLACEBO	24	arm, final	133.500	2.296	43		R0001573:Table 2
S002904	A1	LIRAGL_SC_0p9MG_QD	24	arm, final	126.667	2.122	59	median_converted	R0003210:Table 1
S002904	A2	LIRA_SC_0p9MG_QD	24	arm, final	132.000	1.570	57	median_converted	R0003210:Table 1
S002928	A1	PLACEBO	24	arm, change	-0.790	3.523	35		R0007034:Table 3
S002928	A2	PEGLOX_SC_300UG_QW	24	arm, change	0.480	3.472	35		R0007034:Table 3
S002928	A3	PEGLOX_SC_400UG_QW	24	arm, change	-0.740	3.490	35		R0007034:Table 3
S002969	A1	LIRA_SC_1p8MG_QD	26.07	arm, change	6.333	4.136	12	median_converted	R0010852:Supplementary Table 12
S002969	A2	PLACEBO	26.07	arm, change	-3.003	0.616	13	median_converted	R0010852:Supplementary Table 12
S003009	A1	PEGLOX_SC_0p2MG_QW	24	arm, change	-7.200	0.944	40		R0011381:Table 2
S003009	A2	DAPAGLIFLOZIN	24	arm, change	-4.600	0.969	40		R0011381:Table 2
S003036	A1	SEMA_PO_7MG_QD	24	arm, final	130.500	4.103	24		R0017250:Table 2
S003036	A2	OTHER_ACTIVE_dpp4_inhibitor	24	arm, final	131.600	3.483	27		R0017250:Table 2
S003044	A1	EXEN_SC_10UG_BID	24	arm, final	126.833	2.167	40	median_converted	R0023353:Table 2
S003044	A2	INS_PREMIX	24	arm, final	128.700	1.655	41		R0023353:Table 2
S003068	A1	LIRA_SC_0p9MG_QD	24	arm, final	131.000	3.889	8		R0025603:Table 3
S003068	A2	STANDARD_CARE	24	arm, final	144.000	7.000	9		R0025603:Table 3
S003108	A1	LIRA_SC_FLEX_0p6-1p2-1p8_QD	24	arm, final	134.000	1.278	30		R0025278:Table 2
S003108	A2	METFORMIN	24	arm, final	141.000	1.278	30		R0025278:Table 2
S003108	A3	LIRA_SC_1p8MG_QD	24	arm, final	135.000	1.278	30		R0025278:Table 2
S003108	A4	LIRAMETF_SC_1p2-1500MG_QD	24	arm, final	132.000	1.461	30		R0025278:Table 2
S003152	A1	LIRA_SC_1p2MG_QD	24	arm, change	-3.980	2.497	143		R0022648:Table 3
S003152	A2	DAPAGLIFLOZIN	24	arm, change	-5.280	1.610	166		R0022648:Table 3

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