LivingGLP1
Network meta-analysis

Level 2 or 3 hypoglycemia (participants)

Type 2 diabetes (adults)

longest follow-upRecorded harmsEach dose separatelyHazard ratio (from event counts)
69
Randomized trials
70
Treatments
36,318
Participants
6,104
Events

In plain language

Across 69 trials with 36,318 participants, 1 of 69 treatments had a clearly better result than placebo on level 2 or 3 hypoglycemia (participants), 7 a clearly worse one, and for 61 the evidence could not tell them apart from placebo. The most favorable estimate was for Dulaglutide 0.25 mg injection once weekly: hazard ratio (from event counts) 0.18 (95% credible interval 0.00 to 3.43).

Lower values favor the treatment. "Clearly" means the 95% credible interval excludes no difference. These are averages across trials; they do not say how any one person will respond. Not medical advice.

Network of trials

Each circle is a treatment; each line joins treatments that were randomized against each other in at least one trial.
ALBI_SC_30MG_QWALBI_SC_50MG_QWBEIN_SC_0p2MG_TIDCANAGLIFLOZINCANALIRA_SC_1p8-300MG_QDDANU_PO_10MG_BIDDANU_PO_120MG_BIDDANU_PO_2p5MG_BIDDANU_PO_40MG_BIDDANU_PO_80MG_BIDDULA_SC_0p25MG_QWDULA_SC_0p5MG_QWDULA_SC_0p75MG_QWDULA_SC_1p5MG_QWEFPE_SC_2MG_QWEFPE_SC_4MG_QWEFPE_SC_6MG_QWEMPAGLIFLOZINEXENER_SC_2MG_QWEXENROSI_SC_10-4UG_BIDEXEN_SC_10UG_BIDEXEN_SC_2p5UG_BIDEXEN_SC_5UG_BIDGLIMEPIRIDEHRS7535_PO_30MG_QDHRS7535_PO_90MG_QDIGLARLIXI2_SC_TIT_QDINS_GLARGINEINS_LISPROINS_PREMIXLIRAMETF_SC_1p2-1500MG_QDLIRA_SC_0p9MG_QDLIRA_SC_1p2MG_OTHERLIRA_SC_1p8MG_QDLIRA_SC_FLEX_0p6-1p2-1p8_QDLIRA_SC_FLEX_1p2-1p8_QDLIXI_SC_10UG_BIDLIXI_SC_10UG_QDLIXI_SC_20UG_BIDLIXI_SC_20UG_QDLIXI_SC_30UG_BIDLIXI_SC_30UG_QDLIXI_SC_5UG_BIDLIXI_SC_5UG_QDMAZD_SC_3MG_QWMAZD_SC_4p5MG_QWMAZD_SC_6MG_QWMETFORMINORFO_PO_12MG_QDORFO_PO_24MG_QDORFO_PO_45MG_QDPIOGLITAZONEPLACEBOROSIGLITAZONESEMA_PO_14MG_QDSEMA_PO_3MG_QDSEMA_PO_7MG_QDSEMA_SC_0p5MG_QWSEMA_SC_1p0MG_QWSEMA_SC_2p0MG_QWSEMA_SC_2p4MG_QWSITAGLIPTINSTANDARD_CARETASP_SC_10MG_QWTASP_SC_20MG_QWTASP_SC_30MG_QWTASP_SC_40MG_QWTIRZ_SC_5MG_QWVILDAGLIPTINVISEPE_SC_150UG_QW
Node area shows participants; line width shows trials comparing two treatments directly. Blue: GLP-1 receptor agonist containing treatments; grey: comparators. Hover over or tab to a node or line for details.

Effects compared with Placebo

Hazard ratio (from event counts). Lower values favor the treatment.
0.010.020.050.10.20.250.51245102050100← favors treatmentfavors reference →Dulaglutide 0.25 mg injection on…CanagliflozinSemaglutide 1.0 mg subcutaneous …Liraglutide flexible dose inject…Liraglutide flexible dose inject…Efpeglenatide 2 mg subcutaneous …Mazdutide 4.5 mg subcutaneous on…Orforglipron 45 mg oral once dailySemaglutide 0.5 mg subcutaneous …Orforglipron 12 mg oral once dailyVildagliptinSemaglutide 3 mg oral once daily…Liraglutide 1.2 mg injectionMetforminHRS-7535 90 mg tablet once dailyPioglitazoneTirzepatide 5 mg subcutaneous on…Danuglipron 2.5 mg tablet twice …Danuglipron 10 mg tablet twice d…SitagliptinDulaglutide 0.5 mg injection onc…Exenatide 2.5 µg injection twice…Liraglutide and metformin 1.2 to…Taspoglutide 20 mg subcutaneous …Dulaglutide 1.5 mg subcutaneous …Liraglutide 0.9 mg injection onc…Semaglutide 7 mg oral once daily…Dulaglutide 0.75 mg subcutaneous…Liraglutide 1.8 mg subcutaneous …Beinaglutide 0.2 mg subcutaneous…Lixisenatide 10 µg injection twi…Semaglutide 14 mg oral once dail…Exenatide extended release 2 mg …RosiglitazoneIGlarLixi 2:1 pen subcutaneous o…Lixisenatide 5 µg injection once…Albiglutide 30 mg subcutaneous o…Visepegenatide 150 µg injection …Taspoglutide 10 mg subcutaneous …Semaglutide 2.4 mg subcutaneous …Liraglutide plus canagliflozin 1…Lixisenatide 20 ug subcutaneous …Albiglutide 50 mg subcutaneous o…Semaglutide 2.0 mg subcutaneous …Taspoglutide 40 mg injection onc…Exenatide 5 ug subcutaneous twic…Exenatide 10 ug subcutaneous twi…Exenatide and rosiglitazone 10 t…Lixisenatide 30 µg injection onc…Premixed insulinEmpagliflozinLixisenatide 30 µg injection twi…Efpeglenatide 6 mg subcutaneous …Efpeglenatide 4 mg subcutaneous …Insulin glargineTaspoglutide 30 mg injection onc…Danuglipron 120 mg oral twice da…Lixisenatide 10 µg injection onc…Insulin lispro (prandial)Standard care or no added treatm…GlimepirideHRS-7535 30 mg tablet once dailyMazdutide 6 mg subcutaneous once…Mazdutide 3 mg subcutaneous once…Lixisenatide 20 µg injection twi…Lixisenatide 5 µg injection twic…Danuglipron 40 mg oral twice dailyOrforglipron 24 mg oral once dailyDanuglipron 80 mg oral twice daily
Versus Placebo, log scale. Blue: Bayesian random effects posterior median with 95% credible interval (thick) and 95% prediction interval (dashed). Amber diamond: frequentist estimate with 95% confidence interval. Hover over or tab to a row for its values.
Effects of each treatment versus Placebo
TreatmentBayesian HR (95% CrI)95% prediction intervalFrequentist HR (95% CI)Verdict
Dulaglutide 0.25 mg injection once weekly
DULA_SC_0p25MG_QW
0.18 (0.00 to 3.43)0.00 to 3.71Unclear
Canagliflozin
CANAGLIFLOZIN
0.19 (0.02 to 1.15)0.02 to 1.32Unclear
Semaglutide 1.0 mg subcutaneous once weekly
SEMA_SC_1p0MG_QW
0.26 (0.03 to 1.59)0.03 to 1.85Unclear
Liraglutide flexible dose injection once daily
LIRA_SC_FLEX_1p2-1p8_QD
0.30 (0.10 to 0.87)0.07 to 1.06Better
Liraglutide flexible dose injection once daily
LIRA_SC_FLEX_0p6-1p2-1p8_QD
0.31 (0.04 to 1.65)0.04 to 1.95Unclear
Efpeglenatide 2 mg subcutaneous once weekly
EFPE_SC_2MG_QW
0.32 (0.00 to 8.90)0.00 to 9.44Unclear
Mazdutide 4.5 mg subcutaneous once weekly
MAZD_SC_4p5MG_QW
0.39 (0.00 to 13.34)0.00 to 14.58Unclear
Orforglipron 45 mg oral once daily
ORFO_PO_45MG_QD
0.40 (0.01 to 17.61)0.01 to 18.80Unclear
Semaglutide 0.5 mg subcutaneous once weekly
SEMA_SC_0p5MG_QW
0.41 (0.01 to 10.73)0.01 to 11.36Unclear
Orforglipron 12 mg oral once daily
ORFO_PO_12MG_QD
0.46 (0.01 to 20.33)0.00 to 21.84Unclear
Vildagliptin
VILDAGLIPTIN
0.51 (0.01 to 33.34)0.01 to 34.19Unclear
Semaglutide 3 mg oral once daily (original tablet)
SEMA_PO_3MG_QD
0.61 (0.19 to 1.93)0.15 to 2.34Unclear
Liraglutide 1.2 mg injection
LIRA_SC_1p2MG_OTHER
0.75 (0.01 to 64.91)0.01 to 73.14Unclear
Metformin
METFORMIN
0.79 (0.24 to 2.39)0.19 to 2.94Unclear
HRS-7535 90 mg tablet once daily
HRS7535_PO_90MG_QD
0.84 (0.11 to 5.89)0.10 to 6.51Unclear
Pioglitazone
PIOGLITAZONE
0.85 (0.21 to 2.93)0.17 to 3.65Unclear
Tirzepatide 5 mg subcutaneous once weekly
TIRZ_SC_5MG_QW
0.90 (0.03 to 25.38)0.03 to 27.22Unclear
Danuglipron 2.5 mg tablet twice daily
DANU_PO_2p5MG_BID
0.91 (0.06 to 8.80)0.06 to 10.07Unclear
Danuglipron 10 mg tablet twice daily
DANU_PO_10MG_BID
0.93 (0.06 to 8.60)0.05 to 9.86Unclear
Sitagliptin
SITAGLIPTIN
0.94 (0.51 to 1.62)0.34 to 2.23Unclear
Dulaglutide 0.5 mg injection once weekly
DULA_SC_0p5MG_QW
1.04 (0.08 to 10.47)0.07 to 11.95Unclear
Exenatide 2.5 µg injection twice daily
EXEN_SC_2p5UG_BID
1.07 (0.41 to 2.72)0.32 to 3.42Unclear
Liraglutide and metformin 1.2 to 1500 mg injection once daily
LIRAMETF_SC_1p2-1500MG_QD
1.15 (0.21 to 5.88)0.19 to 7.00Unclear
Taspoglutide 20 mg subcutaneous once weekly
TASP_SC_20MG_QW
1.16 (0.60 to 2.17)0.42 to 3.00Unclear
Dulaglutide 1.5 mg subcutaneous once weekly
DULA_SC_1p5MG_QW
1.18 (0.66 to 1.89)0.44 to 2.81Unclear
Liraglutide 0.9 mg injection once daily
LIRA_SC_0p9MG_QD
1.18 (0.46 to 2.83)0.35 to 3.64Unclear
Semaglutide 7 mg oral once daily (original tablet)
SEMA_PO_7MG_QD
1.19 (0.39 to 3.52)0.31 to 4.44Unclear
Dulaglutide 0.75 mg subcutaneous once weekly
DULA_SC_0p75MG_QW
1.21 (0.65 to 2.15)0.44 to 3.01Unclear
Liraglutide 1.8 mg subcutaneous once daily
LIRA_SC_1p8MG_QD
1.22 (0.61 to 2.29)0.43 to 3.17Unclear
Beinaglutide 0.2 mg subcutaneous three times daily
BEIN_SC_0p2MG_TID
1.22 (0.28 to 4.69)0.23 to 5.51Unclear
Lixisenatide 10 µg injection twice daily
LIXI_SC_10UG_BID
1.24 (0.09 to 8.51)0.08 to 10.19Unclear
Semaglutide 14 mg oral once daily (original tablet)
SEMA_PO_14MG_QD
1.25 (0.42 to 3.74)0.34 to 4.54Unclear
Exenatide extended release 2 mg subcutaneous once weekly
EXENER_SC_2MG_QW
1.25 (0.36 to 4.10)0.29 to 5.13Unclear
Rosiglitazone
ROSIGLITAZONE
1.27 (0.32 to 4.51)0.26 to 5.48Unclear
IGlarLixi 2:1 pen subcutaneous once daily titrated
IGLARLIXI2_SC_TIT_QD
1.29 (0.46 to 3.80)0.37 to 4.98Unclear
Lixisenatide 5 µg injection once daily
LIXI_SC_5UG_QD
1.29 (0.09 to 8.62)0.08 to 9.63Unclear
Albiglutide 30 mg subcutaneous once weekly
ALBI_SC_30MG_QW
1.31 (0.51 to 3.22)0.39 to 4.17Unclear
Visepegenatide 150 µg injection once weekly
VISEPE_SC_150UG_QW
1.36 (0.52 to 3.62)0.42 to 4.72Unclear
Taspoglutide 10 mg subcutaneous once weekly
TASP_SC_10MG_QW
1.38 (0.71 to 2.62)0.50 to 3.56Unclear
Semaglutide 2.4 mg subcutaneous once weekly
SEMA_SC_2p4MG_QW
1.42 (0.59 to 3.58)0.43 to 4.77Unclear
Liraglutide plus canagliflozin 1.8 to 300 mg injection once daily
CANALIRA_SC_1p8-300MG_QD
1.43 (0.23 to 8.90)0.19 to 10.24Unclear
Lixisenatide 20 ug subcutaneous once daily
LIXI_SC_20UG_QD
1.50 (1.09 to 2.10)0.65 to 3.40Worse
Albiglutide 50 mg subcutaneous once weekly
ALBI_SC_50MG_QW
1.61 (0.74 to 3.41)0.53 to 4.46Unclear
Semaglutide 2.0 mg subcutaneous once weekly
SEMA_SC_2p0MG_QW
1.65 (0.54 to 4.84)0.42 to 6.07Unclear
Taspoglutide 40 mg injection once weekly
TASP_SC_40MG_QW
1.69 (0.23 to 11.90)0.19 to 14.17Unclear
Exenatide 5 ug subcutaneous twice daily
EXEN_SC_5UG_BID
1.73 (0.99 to 2.97)0.68 to 4.39Unclear
Exenatide 10 ug subcutaneous twice daily
EXEN_SC_10UG_BID
1.84 (1.24 to 2.68)0.79 to 4.21Worse
Exenatide and rosiglitazone 10 to 4 µg injection twice daily
EXENROSI_SC_10-4UG_BID
1.90 (0.55 to 6.45)0.42 to 7.86Unclear
Lixisenatide 30 µg injection once daily
LIXI_SC_30UG_QD
2.05 (0.63 to 6.44)0.51 to 7.69Unclear
Premixed insulin
INS_PREMIX
2.10 (0.98 to 4.75)0.75 to 6.34Unclear
Empagliflozin
EMPAGLIFLOZIN
2.20 (0.23 to 26.89)0.20 to 29.95Unclear
Lixisenatide 30 µg injection twice daily
LIXI_SC_30UG_BID
2.20 (0.70 to 7.07)0.54 to 8.63Unclear
Efpeglenatide 6 mg subcutaneous once weekly
EFPE_SC_6MG_QW
2.58 (0.11 to 47.21)0.10 to 55.46Unclear
Efpeglenatide 4 mg subcutaneous once weekly
EFPE_SC_4MG_QW
2.62 (0.13 to 55.59)0.11 to 59.58Unclear
Insulin glargine
INS_GLARGINE
2.63 (1.55 to 4.41)1.05 to 6.31Worse
Taspoglutide 30 mg injection once weekly
TASP_SC_30MG_QW
2.67 (0.42 to 17.07)0.38 to 19.80Unclear
Danuglipron 120 mg oral twice daily
DANU_PO_120MG_BID
2.77 (0.40 to 19.34)0.34 to 22.63Unclear
Lixisenatide 10 µg injection once daily
LIXI_SC_10UG_QD
2.87 (0.37 to 15.26)0.31 to 17.68Unclear
Insulin lispro (prandial)
INS_LISPRO
3.06 (1.49 to 6.20)1.05 to 8.38Worse
Standard care or no added treatment
STANDARD_CARE
3.69 (1.40 to 9.15)1.07 to 11.97Worse
Glimepiride
GLIMEPIRIDE
3.73 (1.89 to 6.86)1.35 to 9.39Worse
HRS-7535 30 mg tablet once daily
HRS7535_PO_30MG_QD
3.77 (0.85 to 20.93)0.70 to 23.51Unclear
Mazdutide 6 mg subcutaneous once weekly
MAZD_SC_6MG_QW
4.27 (0.17 to 83.25)0.15 to 88.99Unclear
Mazdutide 3 mg subcutaneous once weekly
MAZD_SC_3MG_QW
4.32 (0.20 to 82.18)0.19 to 90.27Unclear
Lixisenatide 20 µg injection twice daily
LIXI_SC_20UG_BID
4.50 (0.76 to 20.65)0.69 to 25.14Unclear
Lixisenatide 5 µg injection twice daily
LIXI_SC_5UG_BID
4.54 (0.82 to 21.32)0.72 to 24.93Unclear
Danuglipron 40 mg oral twice daily
DANU_PO_40MG_BID
5.23 (0.93 to 33.73)0.79 to 38.06Unclear
Orforglipron 24 mg oral once daily
ORFO_PO_24MG_QD
5.57 (0.18 to 191)0.16 to 210Unclear
Danuglipron 80 mg oral twice daily
DANU_PO_80MG_BID
6.41 (1.23 to 39.86)1.01 to 43.94Worse

Ranking

How likely each treatment is to be among the best. Rankings ignore the size of differences and their certainty, so read them with the effects above.

League table

Every treatment against every other: hazard ratio (from event counts) of the row treatment versus the column treatment, posterior median and 95% credible interval. Green: row clearly better; red: row clearly worse.
Every treatment in a row compared with every treatment in a column
Row versus columnPLACEBODULA_SC_0p25MG_QWCANAGLIFLOZINSEMA_SC_1p0MG_QWLIRA_SC_FLEX_1p2-1p8_QDLIRA_SC_FLEX_0p6-1p2-1p8_QDEFPE_SC_2MG_QWMAZD_SC_4p5MG_QWORFO_PO_45MG_QDSEMA_SC_0p5MG_QWORFO_PO_12MG_QDVILDAGLIPTINSEMA_PO_3MG_QDLIRA_SC_1p2MG_OTHERMETFORMINHRS7535_PO_90MG_QDPIOGLITAZONETIRZ_SC_5MG_QWDANU_PO_2p5MG_BIDDANU_PO_10MG_BIDSITAGLIPTINDULA_SC_0p5MG_QWEXEN_SC_2p5UG_BIDLIRAMETF_SC_1p2-1500MG_QDTASP_SC_20MG_QWDULA_SC_1p5MG_QWLIRA_SC_0p9MG_QDSEMA_PO_7MG_QDDULA_SC_0p75MG_QWLIRA_SC_1p8MG_QDBEIN_SC_0p2MG_TIDLIXI_SC_10UG_BIDSEMA_PO_14MG_QDEXENER_SC_2MG_QWROSIGLITAZONEIGLARLIXI2_SC_TIT_QDLIXI_SC_5UG_QDALBI_SC_30MG_QWVISEPE_SC_150UG_QWTASP_SC_10MG_QWSEMA_SC_2p4MG_QWCANALIRA_SC_1p8-300MG_QDLIXI_SC_20UG_QDALBI_SC_50MG_QWSEMA_SC_2p0MG_QWTASP_SC_40MG_QWEXEN_SC_5UG_BIDEXEN_SC_10UG_BIDEXENROSI_SC_10-4UG_BIDLIXI_SC_30UG_QDINS_PREMIXEMPAGLIFLOZINLIXI_SC_30UG_BIDEFPE_SC_6MG_QWEFPE_SC_4MG_QWINS_GLARGINETASP_SC_30MG_QWDANU_PO_120MG_BIDLIXI_SC_10UG_QDINS_LISPROSTANDARD_CAREGLIMEPIRIDEHRS7535_PO_30MG_QDMAZD_SC_6MG_QWMAZD_SC_3MG_QWLIXI_SC_20UG_BIDLIXI_SC_5UG_BIDDANU_PO_40MG_BIDORFO_PO_24MG_QDDANU_PO_80MG_BID
PLACEBOPLACEBO5.69
0.29 to 323		5.40
0.87 to 46.41		3.84
0.63 to 29.04		3.29
1.15 to 10.35		3.22
0.61 to 24.56		3.16
0.11 to 211		2.55
0.07 to 235		2.51
0.06 to 188		2.43
0.09 to 77.23		2.18
0.05 to 188		1.97
0.03 to 177		1.63
0.52 to 5.33		1.34
0.02 to 174		1.26
0.42 to 4.20		1.19
0.17 to 8.92		1.17
0.34 to 4.70		1.11
0.04 to 33.61		1.10
0.11 to 15.83		1.07
0.12 to 16.49		1.06
0.62 to 1.97		0.97
0.10 to 12.89		0.94
0.37 to 2.46		0.87
0.17 to 4.74		0.86
0.46 to 1.67		0.85
0.53 to 1.52		0.85
0.35 to 2.16		0.84
0.28 to 2.59		0.83
0.46 to 1.53		0.82
0.44 to 1.65		0.82
0.21 to 3.55		0.80
0.12 to 11.45		0.80
0.27 to 2.41		0.80
0.24 to 2.78		0.79
0.22 to 3.08		0.78
0.26 to 2.19		0.77
0.12 to 11.22		0.76
0.31 to 1.97		0.73
0.28 to 1.91		0.73
0.38 to 1.40		0.70
0.28 to 1.70		0.70
0.11 to 4.42		0.67
0.48 to 0.92		0.62
0.29 to 1.36		0.61
0.21 to 1.86		0.59
0.08 to 4.41		0.58
0.34 to 1.01		0.54
0.37 to 0.80		0.53
0.16 to 1.83		0.49
0.16 to 1.59		0.48
0.21 to 1.02		0.45
0.04 to 4.42		0.45
0.14 to 1.43		0.39
0.02 to 8.71		0.38
0.02 to 7.97		0.38
0.23 to 0.65		0.37
0.06 to 2.36		0.36
0.05 to 2.52		0.35
0.07 to 2.73		0.33
0.16 to 0.67		0.27
0.11 to 0.71		0.27
0.15 to 0.53		0.27
0.05 to 1.18		0.23
0.01 to 5.74		0.23
0.01 to 4.91		0.22
0.05 to 1.31		0.22
0.05 to 1.22		0.19
0.03 to 1.08		0.18
0.01 to 5.65		0.16
0.03 to 0.81
DULA_SC_0p25MG_QW0.18
0.00 to 3.43		DULA_SC_0p25MG_QW0.94
0.01 to 37.02		0.65
0.01 to 23.31		0.57
0.01 to 13.52		0.55
0.01 to 19.92		0.57
0.00 to 94.82		0.42
0.00 to 99.90		0.41
0.00 to 77.13		0.39
0.00 to 45.63		0.38
0.00 to 75.91		0.34
0.00 to 80.25		0.28
0.00 to 6.48		0.21
0.00 to 69.11		0.22
0.00 to 5.26		0.21
0.00 to 7.20		0.21
0.00 to 5.60		0.18
0.00 to 20.73		0.19
0.00 to 10.41		0.18
0.00 to 9.39		0.19
0.00 to 3.77		0.17
0.00 to 6.75		0.17
0.00 to 3.72		0.15
0.00 to 4.43		0.15
0.00 to 3.18		0.15
0.00 to 2.99		0.15
0.00 to 3.31		0.15
0.00 to 3.40		0.15
0.00 to 2.86		0.14
0.00 to 2.89		0.14
0.00 to 3.80		0.14
0.00 to 7.25		0.14
0.00 to 3.24		0.14
0.00 to 3.65		0.13
0.00 to 3.54		0.13
0.00 to 3.04		0.14
0.00 to 7.20		0.13
0.00 to 3.00		0.13
0.00 to 2.77		0.13
0.00 to 2.63		0.12
0.00 to 2.63		0.12
0.00 to 4.19		0.12
0.00 to 2.34		0.11
0.00 to 2.33		0.11
0.00 to 2.50		0.10
0.00 to 3.58		0.10
0.00 to 2.06		0.09
0.00 to 1.88		0.09
0.00 to 2.41		0.08
0.00 to 2.08		0.08
0.00 to 1.81		0.07
0.00 to 3.63		0.08
0.00 to 1.91		0.06
0.00 to 4.65		0.06
0.00 to 4.31		0.07
0.00 to 1.32		0.06
0.00 to 2.00		0.06
0.00 to 2.29		0.06
0.00 to 2.20		0.06
0.00 to 1.17		0.05
0.00 to 1.09		0.05
0.00 to 0.98		0.04
0.00 to 1.24		0.04
0.00 to 2.97		0.04
0.00 to 2.89		0.04
0.00 to 1.24		0.04
0.00 to 1.22		0.03
0.00 to 1.08		0.03
0.00 to 2.99		0.03
0.00 to 0.81
CANAGLIFLOZIN0.19
0.02 to 1.15		1.06
0.03 to 93.88		CANAGLIFLOZIN0.71
0.19 to 2.55		0.60
0.06 to 5.05		0.59
0.09 to 4.16		0.60
0.01 to 57.33		0.48
0.01 to 60.44		0.44
0.01 to 49.41		0.45
0.01 to 21.68		0.40
0.01 to 41.41		0.37
0.00 to 46.00		0.30
0.03 to 2.63		0.25
0.00 to 45.74		0.23
0.02 to 1.83		0.22
0.01 to 3.23		0.22
0.02 to 2.04		0.20
0.00 to 9.70		0.20
0.01 to 5.35		0.20
0.01 to 5.38		0.20
0.02 to 1.30		0.18
0.01 to 4.19		0.17
0.02 to 1.36		0.16
0.01 to 1.72		0.16
0.02 to 1.11		0.16
0.02 to 1.06		0.16
0.02 to 1.19		0.15
0.02 to 1.31		0.16
0.02 to 1.01		0.15
0.02 to 0.94		0.16
0.01 to 1.48		0.15
0.01 to 3.73		0.15
0.01 to 1.29		0.15
0.01 to 1.27		0.15
0.01 to 1.38		0.14
0.01 to 1.18		0.15
0.01 to 3.59		0.14
0.01 to 1.11		0.14
0.01 to 1.05		0.14
0.02 to 0.92		0.13
0.01 to 1.03		0.13
0.01 to 1.31		0.12
0.01 to 0.79		0.11
0.01 to 0.80		0.11
0.01 to 0.91		0.11
0.01 to 1.66		0.11
0.01 to 0.73		0.10
0.01 to 0.64		0.10
0.01 to 0.86		0.09
0.01 to 0.78		0.09
0.01 to 0.63		0.08
0.00 to 1.61		0.08
0.01 to 0.74		0.07
0.00 to 2.55		0.07
0.00 to 2.48		0.07
0.01 to 0.45		0.07
0.00 to 0.93		0.07
0.00 to 1.01		0.06
0.00 to 1.07		0.06
0.01 to 0.41		0.05
0.01 to 0.39		0.05
0.01 to 0.33		0.05
0.00 to 0.50		0.04
0.00 to 1.72		0.04
0.00 to 1.59		0.04
0.00 to 0.51		0.04
0.00 to 0.51		0.03
0.00 to 0.47		0.03
0.00 to 1.68		0.03
0.00 to 0.35
SEMA_SC_1p0MG_QW0.26
0.03 to 1.59		1.53
0.04 to 126		1.40
0.39 to 5.40		SEMA_SC_1p0MG_QW0.86
0.09 to 7.29		0.85
0.18 to 4.11		0.84
0.02 to 80.49		0.66
0.01 to 87.21		0.66
0.01 to 67.30		0.63
0.01 to 30.04		0.57
0.01 to 60.44		0.53
0.00 to 63.18		0.42
0.04 to 3.56		0.34
0.00 to 60.07		0.33
0.04 to 2.47		0.31
0.02 to 4.59		0.31
0.03 to 2.73		0.29
0.01 to 13.64		0.29
0.01 to 7.00		0.28
0.01 to 7.14		0.28
0.03 to 1.80		0.26
0.01 to 6.10		0.24
0.03 to 1.88		0.22
0.02 to 2.28		0.23
0.03 to 1.47		0.22
0.03 to 1.42		0.22
0.03 to 1.60		0.22
0.02 to 1.78		0.22
0.03 to 1.40		0.22
0.03 to 1.35		0.21
0.02 to 2.09		0.22
0.01 to 5.03		0.21
0.02 to 1.71		0.21
0.02 to 1.76		0.21
0.02 to 1.91		0.20
0.02 to 1.59		0.21
0.01 to 4.80		0.20
0.02 to 1.50		0.19
0.02 to 1.52		0.19
0.02 to 1.27		0.18
0.02 to 1.37		0.18
0.02 to 1.95		0.17
0.02 to 1.08		0.16
0.02 to 1.12		0.16
0.02 to 1.26		0.15
0.01 to 2.45		0.15
0.02 to 0.98		0.14
0.02 to 0.89		0.14
0.01 to 1.22		0.13
0.01 to 1.06		0.12
0.01 to 0.85		0.12
0.00 to 2.23		0.12
0.01 to 0.99		0.10
0.00 to 3.86		0.10
0.00 to 3.29		0.10
0.01 to 0.61		0.10
0.01 to 1.33		0.09
0.01 to 1.43		0.09
0.01 to 1.50		0.08
0.01 to 0.59		0.07
0.01 to 0.54		0.07
0.01 to 0.46		0.07
0.01 to 0.73		0.06
0.00 to 2.37		0.06
0.00 to 2.18		0.06
0.00 to 0.74		0.06
0.00 to 0.75		0.05
0.00 to 0.64		0.05
0.00 to 2.21		0.04
0.00 to 0.47
LIRA_SC_FLEX_1p2-1p8_QD0.30
0.10 to 0.87		1.75
0.07 to 108		1.66
0.20 to 16.48		1.17
0.14 to 10.97		LIRA_SC_FLEX_1p2-1p8_QD0.97
0.13 to 8.83		0.97
0.03 to 68.03		0.77
0.02 to 80.26		0.73
0.01 to 65.29		0.72
0.02 to 27.55		0.65
0.01 to 63.64		0.60
0.01 to 56.43		0.50
0.11 to 2.22		0.42
0.00 to 55.86		0.38
0.10 to 1.53		0.37
0.04 to 3.47		0.36
0.08 to 1.72		0.34
0.01 to 11.77		0.33
0.02 to 6.05		0.32
0.03 to 6.06		0.32
0.12 to 0.82		0.29
0.02 to 4.63		0.28
0.06 to 1.22		0.26
0.04 to 1.83		0.26
0.08 to 0.82		0.26
0.08 to 0.78		0.26
0.07 to 0.92		0.25
0.06 to 1.12		0.25
0.08 to 0.77		0.25
0.08 to 0.76		0.24
0.04 to 1.42		0.25
0.02 to 4.10		0.24
0.05 to 0.99		0.24
0.06 to 0.99		0.24
0.04 to 1.29		0.24
0.05 to 1.00		0.24
0.03 to 4.06		0.23
0.06 to 0.94		0.22
0.05 to 0.90		0.22
0.06 to 0.67		0.21
0.05 to 0.84		0.21
0.03 to 1.70		0.20
0.06 to 0.59		0.19
0.05 to 0.69		0.18
0.04 to 0.79		0.18
0.02 to 1.70		0.18
0.05 to 0.58		0.16
0.05 to 0.47		0.16
0.03 to 0.80		0.15
0.03 to 0.70		0.14
0.04 to 0.50		0.14
0.01 to 1.63		0.14
0.03 to 0.66		0.12
0.01 to 3.15		0.12
0.00 to 2.79		0.11
0.04 to 0.33		0.11
0.01 to 0.91		0.11
0.01 to 0.99		0.11
0.01 to 1.07		0.10
0.03 to 0.34		0.08
0.02 to 0.32		0.08
0.03 to 0.24		0.08
0.01 to 0.52		0.07
0.00 to 2.01		0.07
0.00 to 1.71		0.07
0.01 to 0.51		0.07
0.01 to 0.48		0.06
0.01 to 0.45		0.05
0.00 to 2.00		0.05
0.01 to 0.34
LIRA_SC_FLEX_0p6-1p2-1p8_QD0.31
0.04 to 1.65		1.81
0.05 to 134		1.69
0.24 to 11.48		1.18
0.24 to 5.71		1.03
0.11 to 7.73		LIRA_SC_FLEX_0p6-1p2-1p8_QD0.98
0.02 to 88.63		0.77
0.01 to 92.44		0.76
0.01 to 76.33		0.73
0.02 to 34.04		0.67
0.01 to 73.59		0.62
0.01 to 77.68		0.50
0.05 to 3.71		0.41
0.00 to 67.93		0.39
0.05 to 2.44		0.36
0.02 to 5.13		0.36
0.04 to 2.76		0.34
0.01 to 15.53		0.34
0.02 to 8.61		0.33
0.02 to 8.17		0.33
0.04 to 1.81		0.30
0.01 to 6.79		0.29
0.03 to 1.97		0.27
0.03 to 2.13		0.27
0.03 to 1.60		0.27
0.03 to 1.51		0.26
0.03 to 1.74		0.26
0.03 to 1.88		0.26
0.03 to 1.46		0.26
0.03 to 1.34		0.25
0.02 to 2.26		0.26
0.02 to 5.83		0.24
0.03 to 1.78		0.25
0.03 to 1.76		0.25
0.02 to 2.10		0.24
0.03 to 1.76		0.25
0.01 to 5.21		0.24
0.03 to 1.53		0.23
0.02 to 1.59		0.23
0.03 to 1.33		0.22
0.02 to 1.49		0.21
0.02 to 2.24		0.21
0.03 to 1.09		0.19
0.02 to 1.16		0.19
0.02 to 1.32		0.18
0.01 to 2.61		0.18
0.02 to 1.02		0.17
0.02 to 0.93		0.16
0.02 to 1.33		0.15
0.02 to 1.16		0.15
0.02 to 0.91		0.14
0.01 to 2.36		0.14
0.01 to 1.05		0.11
0.00 to 4.14		0.11
0.00 to 3.74		0.12
0.01 to 0.66		0.11
0.01 to 1.33		0.11
0.01 to 1.49		0.11
0.01 to 1.54		0.10
0.01 to 0.60		0.08
0.01 to 0.59		0.08
0.01 to 0.47		0.08
0.01 to 0.77		0.07
0.00 to 2.71		0.07
0.00 to 2.40		0.07
0.01 to 0.84		0.07
0.01 to 0.74		0.06
0.00 to 0.67		0.05
0.00 to 2.35		0.05
0.00 to 0.52
EFPE_SC_2MG_QW0.32
0.00 to 8.90		1.77
0.01 to 358		1.66
0.02 to 85.75		1.19
0.01 to 59.34		1.03
0.01 to 35.32		1.03
0.01 to 49.39		EFPE_SC_2MG_QW0.76
0.00 to 238		0.75
0.00 to 202		0.73
0.00 to 110		0.70
0.00 to 165		0.58
0.00 to 184		0.50
0.01 to 17.29		0.40
0.00 to 160		0.41
0.01 to 13.40		0.37
0.00 to 18.44		0.37
0.00 to 13.49		0.33
0.00 to 43.77		0.34
0.00 to 25.31		0.34
0.00 to 25.30		0.33
0.01 to 9.83		0.31
0.00 to 20.68		0.30
0.00 to 9.77		0.27
0.00 to 11.01		0.27
0.00 to 8.12		0.27
0.00 to 8.17		0.27
0.00 to 8.22		0.26
0.00 to 8.19		0.26
0.00 to 7.70		0.26
0.00 to 7.72		0.25
0.00 to 9.68		0.26
0.00 to 19.26		0.24
0.00 to 8.28		0.25
0.00 to 8.41		0.24
0.00 to 9.03		0.24
0.00 to 7.82		0.26
0.00 to 16.39		0.24
0.00 to 8.01		0.22
0.00 to 7.38		0.23
0.00 to 6.70		0.21
0.00 to 7.29		0.21
0.00 to 10.14		0.21
0.00 to 5.93		0.19
0.00 to 6.16		0.19
0.00 to 6.64		0.18
0.00 to 9.95		0.18
0.00 to 5.39		0.17
0.00 to 4.90		0.16
0.00 to 5.47		0.15
0.00 to 5.31		0.15
0.00 to 4.50		0.13
0.00 to 8.72		0.14
0.00 to 4.90		0.12
0.00 to 7.25		0.12
0.00 to 6.82		0.12
0.00 to 3.49		0.11
0.00 to 6.02		0.11
0.00 to 5.56		0.11
0.00 to 4.85		0.10
0.00 to 3.09		0.08
0.00 to 2.76		0.08
0.00 to 2.46		0.08
0.00 to 3.26		0.07
0.00 to 7.57		0.07
0.00 to 7.41		0.07
0.00 to 3.19		0.07
0.00 to 2.97		0.06
0.00 to 2.72		0.05
0.00 to 6.11		0.05
0.00 to 2.12
MAZD_SC_4p5MG_QW0.39
0.00 to 13.34		2.37
0.01 to 431		2.08
0.02 to 137		1.51
0.01 to 97.80		1.30
0.01 to 54.37		1.29
0.01 to 76.96		1.31
0.00 to 348		MAZD_SC_4p5MG_QW0.93
0.00 to 264		0.93
0.00 to 155		0.83
0.00 to 248		0.74
0.00 to 233		0.65
0.01 to 25.03		0.51
0.00 to 240		0.49
0.00 to 20.41		0.47
0.00 to 27.81		0.46
0.00 to 20.15		0.43
0.00 to 68.44		0.44
0.00 to 36.13		0.42
0.00 to 34.24		0.43
0.00 to 15.43		0.39
0.00 to 31.37		0.37
0.00 to 13.98		0.34
0.00 to 17.77		0.34
0.00 to 12.09		0.34
0.00 to 12.04		0.34
0.00 to 13.06		0.33
0.00 to 12.13		0.33
0.00 to 11.66		0.33
0.00 to 11.32		0.32
0.00 to 14.71		0.33
0.00 to 27.61		0.31
0.00 to 11.73		0.32
0.00 to 13.30		0.31
0.00 to 13.94		0.30
0.00 to 12.15		0.32
0.00 to 24.72		0.30
0.00 to 10.72		0.28
0.00 to 11.59		0.28
0.00 to 10.33		0.27
0.00 to 10.76		0.27
0.00 to 15.69		0.26
0.00 to 9.20		0.25
0.00 to 9.01		0.24
0.00 to 8.93		0.24
0.00 to 14.57		0.23
0.00 to 7.99		0.22
0.00 to 7.49		0.20
0.00 to 8.55		0.19
0.00 to 8.21		0.19
0.00 to 6.79		0.17
0.00 to 12.41		0.17
0.00 to 7.77		0.15
0.00 to 15.41		0.15
0.00 to 15.52		0.15
0.00 to 5.05		0.14
0.00 to 7.98		0.14
0.00 to 8.18		0.14
0.00 to 8.38		0.13
0.00 to 4.52		0.11
0.00 to 4.08		0.11
0.00 to 3.86		0.10
0.00 to 5.24		0.10
0.00 to 7.40		0.09
0.00 to 6.67		0.09
0.00 to 5.06		0.09
0.00 to 4.49		0.07
0.00 to 4.12		0.07
0.00 to 11.28		0.06
0.00 to 3.11
ORFO_PO_45MG_QD0.40
0.01 to 17.61		2.42
0.01 to 533		2.26
0.02 to 158		1.52
0.01 to 115		1.37
0.02 to 71.13		1.31
0.01 to 96.96		1.34
0.00 to 390		1.08
0.00 to 376		ORFO_PO_45MG_QD0.97
0.00 to 177		0.87
0.00 to 273		0.78
0.00 to 353		0.66
0.01 to 36.60		0.52
0.00 to 272		0.52
0.01 to 26.47		0.47
0.00 to 33.95		0.49
0.01 to 24.99		0.44
0.00 to 79.24		0.47
0.00 to 50.17		0.44
0.00 to 48.04		0.44
0.01 to 19.53		0.39
0.00 to 44.88		0.38
0.00 to 19.37		0.34
0.00 to 21.23		0.35
0.00 to 15.93		0.34
0.00 to 16.25		0.34
0.00 to 16.65		0.34
0.00 to 17.82		0.33
0.00 to 15.85		0.34
0.00 to 15.07		0.34
0.00 to 19.39		0.34
0.00 to 32.42		0.32
0.00 to 17.18		0.33
0.00 to 16.39		0.32
0.00 to 17.31		0.31
0.00 to 16.40		0.33
0.00 to 32.81		0.31
0.00 to 14.95		0.29
0.00 to 16.03		0.29
0.00 to 13.39		0.29
0.00 to 14.73		0.28
0.00 to 18.24		0.26
0.00 to 11.82		0.25
0.00 to 11.88		0.24
0.00 to 13.30		0.24
0.00 to 18.61		0.23
0.00 to 10.89		0.22
0.00 to 9.79		0.21
0.00 to 10.93		0.20
0.00 to 10.59		0.19
0.00 to 9.26		0.18
0.00 to 15.13		0.18
0.00 to 9.94		0.15
0.00 to 20.49		0.15
0.00 to 21.29		0.15
0.00 to 7.03		0.15
0.00 to 10.88		0.14
0.00 to 9.72		0.14
0.00 to 12.28		0.13
0.00 to 6.13		0.11
0.00 to 5.27		0.11
0.00 to 5.40		0.10
0.00 to 5.94		0.09
0.00 to 14.83		0.09
0.00 to 12.47		0.09
0.00 to 6.03		0.09
0.00 to 5.89		0.08
0.00 to 4.87		0.08
0.00 to 5.84		0.06
0.00 to 4.26
SEMA_SC_0p5MG_QW0.41
0.01 to 10.73		2.55
0.02 to 400		2.24
0.05 to 113		1.60
0.03 to 67.55		1.38
0.04 to 40.56		1.37
0.03 to 58.35		1.38
0.01 to 268		1.08
0.01 to 260		1.03
0.01 to 231		SEMA_SC_0p5MG_QW0.92
0.01 to 207		0.83
0.00 to 210		0.67
0.02 to 21.19		0.56
0.00 to 208		0.51
0.01 to 16.29		0.50
0.01 to 21.15		0.49
0.01 to 16.24		0.48
0.03 to 5.83		0.46
0.01 to 30.81		0.45
0.01 to 31.38		0.44
0.01 to 12.76		0.40
0.01 to 27.14		0.39
0.01 to 11.08		0.36
0.01 to 14.03		0.36
0.01 to 10.11		0.35
0.01 to 10.02		0.35
0.01 to 10.44		0.34
0.01 to 10.47		0.34
0.01 to 9.27		0.34
0.01 to 9.15		0.34
0.01 to 11.87		0.36
0.01 to 21.94		0.33
0.01 to 9.80		0.33
0.01 to 10.97		0.32
0.01 to 11.16		0.32
0.01 to 9.16		0.35
0.01 to 20.89		0.31
0.01 to 9.44		0.30
0.01 to 9.35		0.30
0.01 to 8.26		0.29
0.01 to 8.76		0.28
0.01 to 12.92		0.27
0.01 to 7.23		0.25
0.01 to 7.02		0.25
0.01 to 7.60		0.24
0.00 to 11.80		0.24
0.01 to 6.54		0.22
0.01 to 5.99		0.22
0.01 to 7.46		0.20
0.01 to 6.11		0.19
0.01 to 5.46		0.18
0.00 to 9.63		0.19
0.01 to 5.98		0.16
0.00 to 14.27		0.15
0.00 to 13.91		0.15
0.00 to 4.15		0.15
0.00 to 6.26		0.15
0.00 to 6.25		0.15
0.00 to 6.26		0.14
0.00 to 3.66		0.11
0.00 to 3.20		0.11
0.00 to 3.07		0.11
0.00 to 3.87		0.09
0.00 to 8.86		0.10
0.00 to 7.72		0.10
0.00 to 3.38		0.09
0.00 to 3.64		0.08
0.00 to 3.14		0.07
0.00 to 8.73		0.06
0.00 to 2.51
ORFO_PO_12MG_QD0.46
0.01 to 20.33		2.65
0.01 to 584		2.48
0.02 to 170		1.74
0.02 to 128		1.53
0.02 to 77.03		1.50
0.01 to 98.70		1.43
0.01 to 410		1.20
0.00 to 379		1.15
0.00 to 248		1.09
0.00 to 176		ORFO_PO_12MG_QD0.88
0.00 to 301		0.76
0.01 to 37.77		0.60
0.00 to 326		0.57
0.01 to 29.23		0.53
0.00 to 34.61		0.55
0.01 to 30.27		0.47
0.00 to 89.53		0.51
0.00 to 49.22		0.50
0.00 to 55.50		0.50
0.01 to 22.10		0.46
0.00 to 41.60		0.43
0.00 to 21.91		0.40
0.00 to 24.72		0.40
0.00 to 18.81		0.40
0.00 to 18.03		0.39
0.00 to 18.88		0.39
0.00 to 20.24		0.38
0.00 to 16.88		0.38
0.00 to 17.17		0.38
0.00 to 21.94		0.39
0.00 to 41.21		0.37
0.00 to 18.35		0.37
0.00 to 19.67		0.37
0.00 to 19.09		0.36
0.00 to 18.10		0.38
0.00 to 32.48		0.36
0.00 to 17.81		0.33
0.00 to 16.75		0.34
0.00 to 15.19		0.32
0.00 to 15.25		0.31
0.00 to 20.21		0.30
0.00 to 13.78		0.28
0.00 to 13.33		0.28
0.00 to 15.41		0.27
0.00 to 20.53		0.27
0.00 to 12.50		0.25
0.00 to 11.36		0.24
0.00 to 13.28		0.23
0.00 to 12.24		0.22
0.00 to 10.27		0.20
0.00 to 16.91		0.21
0.00 to 10.62		0.17
0.00 to 23.35		0.17
0.00 to 20.25		0.17
0.00 to 8.06		0.17
0.00 to 11.33		0.16
0.00 to 11.97		0.16
0.00 to 10.96		0.15
0.00 to 7.07		0.12
0.00 to 5.87		0.13
0.00 to 5.75		0.12
0.00 to 6.81		0.10
0.00 to 14.51		0.10
0.00 to 14.97		0.10
0.00 to 5.91		0.10
0.00 to 6.02		0.08
0.00 to 5.78		0.09
0.00 to 6.45		0.07
0.00 to 4.86
VILDAGLIPTIN0.51
0.01 to 33.34		2.98
0.01 to 866		2.68
0.02 to 288		1.89
0.02 to 206		1.66
0.02 to 131		1.62
0.01 to 177		1.73
0.01 to 662		1.36
0.00 to 608		1.28
0.00 to 521		1.21
0.00 to 302		1.14
0.00 to 482		VILDAGLIPTIN0.81
0.01 to 65.23		0.69
0.00 to 468		0.63
0.01 to 49.33		0.59
0.00 to 69.60		0.60
0.01 to 49.85		0.54
0.00 to 143		0.58
0.00 to 79.32		0.56
0.00 to 85.52		0.54
0.01 to 38.11		0.51
0.00 to 75.16		0.47
0.01 to 34.76		0.45
0.00 to 39.99		0.44
0.00 to 30.95		0.43
0.00 to 30.51		0.42
0.00 to 31.40		0.42
0.00 to 32.05		0.42
0.00 to 29.11		0.41
0.00 to 30.13		0.42
0.00 to 37.05		0.44
0.00 to 56.51		0.40
0.00 to 31.56		0.40
0.00 to 32.99		0.40
0.00 to 31.42		0.39
0.00 to 30.52		0.42
0.00 to 58.87		0.39
0.00 to 27.43		0.37
0.00 to 28.25		0.37
0.00 to 26.31		0.35
0.00 to 26.95		0.34
0.00 to 39.43		0.33
0.00 to 22.68		0.31
0.00 to 21.96		0.30
0.00 to 24.76		0.30
0.00 to 35.42		0.29
0.00 to 19.62		0.28
0.00 to 18.86		0.26
0.00 to 22.31		0.24
0.00 to 19.41		0.24
0.00 to 17.90		0.22
0.00 to 26.59		0.22
0.00 to 18.32		0.19
0.00 to 35.69		0.19
0.00 to 32.38		0.19
0.00 to 13.22		0.18
0.00 to 17.89		0.18
0.00 to 17.55		0.18
0.00 to 20.55		0.17
0.00 to 11.41		0.14
0.00 to 10.29		0.13
0.00 to 9.86		0.13
0.00 to 12.10		0.11
0.00 to 21.88		0.11
0.00 to 21.06		0.11
0.00 to 10.95		0.11
0.00 to 10.58		0.09
0.00 to 8.87		0.09
0.00 to 19.13		0.08
0.00 to 6.93
SEMA_PO_3MG_QD0.61
0.19 to 1.93		3.57
0.15 to 226		3.33
0.38 to 36.50		2.36
0.28 to 23.14		2.01
0.45 to 9.31		1.99
0.27 to 18.74		2.01
0.06 to 143		1.54
0.04 to 162		1.52
0.03 to 133		1.49
0.05 to 58.41		1.32
0.03 to 132		1.23
0.02 to 125		SEMA_PO_3MG_QD0.84
0.01 to 118		0.77
0.16 to 3.72		0.73
0.07 to 7.35		0.73
0.14 to 4.04		0.69
0.02 to 23.82		0.69
0.05 to 11.95		0.65
0.05 to 12.00		0.65
0.20 to 2.21		0.59
0.05 to 10.16		0.58
0.13 to 2.57		0.53
0.07 to 3.98		0.53
0.15 to 1.92		0.53
0.16 to 1.66		0.52
0.14 to 2.06		0.52
0.19 to 1.39		0.51
0.18 to 1.42		0.50
0.15 to 1.75		0.51
0.09 to 3.02		0.50
0.05 to 8.42		0.49
0.19 to 1.27		0.50
0.10 to 2.44		0.48
0.09 to 2.73		0.47
0.10 to 2.21		0.50
0.05 to 8.06		0.46
0.11 to 2.01		0.45
0.09 to 2.03		0.44
0.12 to 1.57		0.43
0.10 to 1.87		0.44
0.05 to 3.57		0.41
0.12 to 1.32		0.38
0.10 to 1.50		0.37
0.08 to 1.72		0.36
0.04 to 3.77		0.36
0.10 to 1.26		0.33
0.10 to 1.08		0.32
0.06 to 1.75		0.30
0.06 to 1.59		0.29
0.07 to 1.11		0.28
0.02 to 3.34		0.28
0.05 to 1.48		0.23
0.01 to 6.72		0.23
0.01 to 6.23		0.23
0.07 to 0.72		0.23
0.03 to 1.94		0.22
0.02 to 2.12		0.22
0.03 to 2.26		0.20
0.05 to 0.75		0.17
0.04 to 0.71		0.16
0.05 to 0.55		0.16
0.02 to 1.12		0.14
0.01 to 4.15		0.14
0.01 to 3.57		0.14
0.02 to 1.11		0.13
0.02 to 1.04		0.12
0.01 to 0.94		0.11
0.00 to 4.10		0.09
0.01 to 0.69
LIRA_SC_1p2MG_OTHER0.75
0.01 to 64.91		4.67
0.01 to 1578		4.07
0.02 to 561		2.90
0.02 to 360		2.40
0.02 to 252		2.42
0.01 to 309		2.49
0.01 to 1105		1.97
0.00 to 1017		1.93
0.00 to 830		1.80
0.00 to 572		1.67
0.00 to 855		1.46
0.00 to 834		1.20
0.01 to 119		LIRA_SC_1p2MG_OTHER0.95
0.01 to 93.31		0.90
0.00 to 121		0.91
0.01 to 90.08		0.81
0.00 to 236		0.82
0.00 to 141		0.84
0.00 to 161		0.80
0.01 to 73.48		0.71
0.00 to 121		0.70
0.00 to 68.66		0.65
0.00 to 72.31		0.65
0.00 to 58.73		0.63
0.00 to 57.05		0.64
0.00 to 57.03		0.62
0.00 to 65.73		0.61
0.00 to 54.01		0.62
0.00 to 59.22		0.61
0.00 to 69.67		0.63
0.00 to 104		0.58
0.00 to 56.84		0.59
0.00 to 56.99		0.58
0.00 to 62.42		0.58
0.00 to 59.88		0.62
0.00 to 113		0.57
0.00 to 53.93		0.54
0.00 to 54.51		0.54
0.00 to 50.68		0.51
0.00 to 51.29		0.52
0.00 to 63.46		0.49
0.00 to 43.01		0.47
0.00 to 40.70		0.46
0.00 to 44.43		0.43
0.00 to 60.06		0.43
0.00 to 38.62		0.40
0.00 to 34.93		0.38
0.00 to 39.62		0.35
0.00 to 38.48		0.35
0.00 to 34.40		0.33
0.00 to 55.92		0.33
0.00 to 33.86		0.28
0.00 to 70.81		0.27
0.00 to 63.71		0.28
0.00 to 25.10		0.27
0.00 to 34.14		0.27
0.00 to 32.55		0.26
0.00 to 35.99		0.24
0.00 to 23.73		0.21
0.00 to 19.05		0.20
0.00 to 17.73		0.19
0.00 to 23.49		0.17
0.00 to 42.32		0.17
0.00 to 38.75		0.16
0.00 to 21.01		0.16
0.00 to 21.47		0.14
0.00 to 16.45		0.13
0.00 to 38.25		0.11
0.00 to 13.82
METFORMIN0.79
0.24 to 2.39		4.54
0.19 to 310		4.34
0.55 to 41.13		3.05
0.40 to 26.39		2.63
0.65 to 10.46		2.55
0.41 to 21.11		2.46
0.07 to 183		2.05
0.05 to 218		1.93
0.04 to 164		1.94
0.06 to 70.96		1.75
0.03 to 162		1.58
0.02 to 165		1.29
0.27 to 6.17		1.06
0.01 to 153		METFORMIN0.94
0.10 to 9.46		0.94
0.28 to 3.26		0.89
0.03 to 33.56		0.88
0.07 to 14.90		0.84
0.07 to 15.24		0.85
0.29 to 2.41		0.77
0.06 to 12.60		0.75
0.17 to 3.18		0.70
0.13 to 3.86		0.68
0.20 to 2.32		0.68
0.21 to 2.19		0.68
0.18 to 2.48		0.67
0.14 to 2.95		0.66
0.19 to 2.11		0.66
0.20 to 1.96		0.66
0.11 to 3.61		0.65
0.06 to 10.86		0.63
0.13 to 2.81		0.64
0.21 to 1.85		0.63
0.11 to 3.41		0.62
0.12 to 2.64		0.64
0.07 to 10.96		0.61
0.15 to 2.51		0.58
0.12 to 2.43		0.58
0.16 to 1.92		0.56
0.12 to 2.29		0.55
0.07 to 4.43		0.53
0.15 to 1.63		0.49
0.13 to 1.80		0.49
0.10 to 2.07		0.47
0.05 to 4.87		0.47
0.12 to 1.51		0.43
0.13 to 1.33		0.42
0.08 to 2.07		0.39
0.08 to 1.88		0.38
0.09 to 1.33		0.36
0.02 to 4.48		0.36
0.07 to 1.74		0.31
0.01 to 8.07		0.30
0.01 to 7.71		0.30
0.09 to 0.93		0.29
0.03 to 2.52		0.28
0.03 to 2.61		0.28
0.03 to 2.92		0.26
0.07 to 0.92		0.21
0.05 to 0.90		0.21
0.06 to 0.69		0.21
0.03 to 1.33		0.18
0.01 to 5.36		0.18
0.01 to 4.56		0.18
0.02 to 1.43		0.18
0.02 to 1.34		0.15
0.02 to 1.21		0.14
0.00 to 5.06		0.12
0.01 to 0.91
HRS7535_PO_90MG_QD0.84
0.11 to 5.89		4.84
0.14 to 388		4.60
0.31 to 75.62		3.24
0.22 to 50.14		2.73
0.29 to 26.50		2.76
0.19 to 42.10		2.73
0.05 to 264		2.15
0.04 to 283		2.15
0.03 to 215		1.98
0.05 to 103		1.87
0.03 to 228		1.70
0.01 to 241		1.37
0.14 to 13.43		1.11
0.01 to 213		1.07
0.11 to 10.25		HRS7535_PO_90MG_QD1.01
0.10 to 10.64		0.94
0.02 to 44.15		0.94
0.04 to 24.59		0.92
0.05 to 25.00		0.89
0.11 to 6.88		0.83
0.04 to 20.33		0.78
0.09 to 6.98		0.74
0.06 to 9.86		0.73
0.09 to 5.60		0.72
0.09 to 5.33		0.72
0.08 to 6.40		0.71
0.07 to 6.70		0.69
0.09 to 5.45		0.69
0.08 to 5.54		0.69
0.06 to 8.11		0.72
0.04 to 16.93		0.67
0.07 to 6.33		0.68
0.06 to 6.54		0.67
0.06 to 7.35		0.64
0.07 to 5.96		0.68
0.04 to 17.29		0.64
0.07 to 5.59		0.62
0.06 to 5.40		0.61
0.07 to 4.68		0.59
0.07 to 5.00		0.59
0.04 to 8.19		0.56
0.07 to 4.01		0.52
0.06 to 4.23		0.51
0.05 to 4.85		0.50
0.03 to 8.20		0.48
0.06 to 3.66		0.45
0.06 to 3.25		0.44
0.04 to 4.39		0.41
0.04 to 3.89		0.39
0.05 to 3.24		0.37
0.02 to 7.71		0.38
0.04 to 3.51		0.32
0.01 to 11.29		0.32
0.01 to 11.23		0.32
0.04 to 2.39		0.31
0.02 to 4.39		0.30
0.02 to 4.59		0.30
0.02 to 4.68		0.28
0.03 to 2.07		0.23
0.03 to 1.88		0.23
0.03 to 1.78		0.22
0.03 to 1.09		0.19
0.01 to 8.23		0.19
0.01 to 7.11		0.19
0.01 to 2.47		0.18
0.02 to 2.49		0.16
0.01 to 2.26		0.15
0.00 to 7.13		0.12
0.01 to 1.72
PIOGLITAZONE0.85
0.21 to 2.93		4.83
0.18 to 323		4.59
0.49 to 51.50		3.20
0.37 to 32.25		2.78
0.58 to 12.74		2.76
0.36 to 25.65		2.73
0.07 to 207		2.16
0.05 to 222		2.06
0.04 to 196		2.05
0.06 to 85.21		1.83
0.03 to 183		1.68
0.02 to 182		1.37
0.25 to 7.41		1.10
0.01 to 173		1.07
0.31 to 3.53		0.99
0.09 to 10.46		PIOGLITAZONE0.95
0.02 to 39.22		0.93
0.06 to 17.81		0.90
0.06 to 18.25		0.91
0.26 to 3.02		0.82
0.06 to 15.05		0.80
0.14 to 3.96		0.74
0.11 to 5.09		0.73
0.18 to 2.74		0.72
0.18 to 2.75		0.72
0.15 to 3.16		0.72
0.13 to 3.63		0.71
0.17 to 2.67		0.70
0.17 to 2.56		0.70
0.10 to 4.39		0.69
0.06 to 13.46		0.68
0.12 to 3.47		0.68
0.20 to 2.25		0.66
0.11 to 3.93		0.66
0.11 to 3.27		0.67
0.06 to 12.34		0.65
0.13 to 3.04		0.63
0.11 to 2.91		0.61
0.15 to 2.36		0.59
0.11 to 2.86		0.58
0.06 to 5.25		0.57
0.13 to 2.05		0.53
0.11 to 2.25		0.51
0.09 to 2.55		0.50
0.05 to 5.44		0.49
0.11 to 1.88		0.46
0.12 to 1.64		0.44
0.07 to 2.47		0.41
0.07 to 2.27		0.40
0.08 to 1.66		0.37
0.02 to 5.06		0.38
0.07 to 2.02		0.33
0.01 to 8.80		0.32
0.01 to 8.44		0.32
0.08 to 1.14		0.31
0.03 to 2.90		0.30
0.03 to 2.97		0.30
0.03 to 3.23		0.28
0.06 to 1.18		0.23
0.05 to 1.06		0.23
0.06 to 0.86		0.22
0.02 to 1.65		0.19
0.01 to 6.01		0.19
0.01 to 5.14		0.19
0.02 to 1.60		0.19
0.02 to 1.56		0.16
0.02 to 1.36		0.15
0.00 to 5.83		0.13
0.01 to 1.08
TIRZ_SC_5MG_QW0.90
0.03 to 25.38		5.56
0.05 to 879		5.02
0.10 to 245		3.47
0.07 to 168		2.98
0.08 to 103		2.94
0.06 to 151		2.99
0.02 to 575		2.32
0.01 to 617		2.25
0.01 to 541		2.06
0.17 to 35.46		2.11
0.01 to 478		1.85
0.01 to 510		1.44
0.04 to 49.33		1.23
0.00 to 413		1.13
0.03 to 39.61		1.07
0.02 to 49.92		1.05
0.03 to 40.22		TIRZ_SC_5MG_QW0.99
0.01 to 70.49		0.99
0.02 to 70.87		0.95
0.03 to 28.82		0.87
0.01 to 66.59		0.84
0.03 to 27.95		0.78
0.02 to 31.60		0.77
0.02 to 22.43		0.76
0.02 to 22.46		0.75
0.02 to 24.64		0.74
0.02 to 24.82		0.74
0.02 to 23.02		0.73
0.02 to 22.17		0.73
0.02 to 26.84		0.76
0.01 to 46.91		0.70
0.02 to 23.75		0.71
0.02 to 26.03		0.71
0.02 to 26.58		0.69
0.02 to 22.18		0.75
0.01 to 47.16		0.69
0.02 to 21.99		0.66
0.02 to 21.54		0.64
0.02 to 19.28		0.64
0.02 to 19.30		0.60
0.01 to 30.35		0.59
0.02 to 17.09		0.56
0.02 to 16.86		0.54
0.02 to 19.45		0.52
0.01 to 27.47		0.51
0.02 to 15.41		0.49
0.02 to 13.98		0.47
0.01 to 15.80		0.44
0.01 to 14.58		0.43
0.01 to 12.72		0.41
0.01 to 23.43		0.41
0.01 to 13.34		0.35
0.00 to 34.04		0.34
0.00 to 29.51		0.34
0.01 to 10.04		0.33
0.01 to 15.69		0.32
0.01 to 15.22		0.33
0.01 to 16.03		0.29
0.01 to 8.84		0.24
0.01 to 7.98		0.24
0.01 to 7.59		0.23
0.01 to 9.44		0.21
0.00 to 20.82		0.20
0.00 to 18.63		0.20
0.00 to 8.55		0.20
0.00 to 8.84		0.17
0.00 to 7.51		0.15
0.00 to 18.68		0.14
0.00 to 6.05
DANU_PO_2p5MG_BID0.91
0.06 to 8.80		5.28
0.10 to 480		4.89
0.19 to 115		3.44
0.14 to 75.11		2.99
0.17 to 40.52		2.95
0.12 to 62.67		2.97
0.04 to 350		2.26
0.03 to 367		2.14
0.02 to 286		2.18
0.03 to 154		1.97
0.02 to 291		1.73
0.01 to 276		1.45
0.08 to 18.84		1.21
0.01 to 272		1.14
0.07 to 15.08		1.06
0.04 to 23.30		1.07
0.06 to 16.31		1.01
0.01 to 66.73		DANU_PO_2p5MG_BID0.98
0.05 to 20.97		0.98
0.06 to 10.40		0.88
0.03 to 27.90		0.85
0.05 to 9.75		0.80
0.04 to 13.70		0.79
0.05 to 8.26		0.78
0.05 to 8.13		0.78
0.05 to 9.09		0.75
0.04 to 9.70		0.75
0.05 to 7.94		0.75
0.05 to 8.12		0.75
0.04 to 10.96		0.75
0.03 to 26.06		0.71
0.04 to 9.24		0.72
0.04 to 9.71		0.71
0.04 to 10.72		0.69
0.04 to 8.96		0.73
0.03 to 24.75		0.69
0.04 to 8.16		0.66
0.04 to 7.72		0.66
0.04 to 6.94		0.63
0.04 to 6.94		0.63
0.02 to 13.80		0.61
0.04 to 6.00		0.56
0.04 to 6.23		0.55
0.03 to 7.29		0.53
0.02 to 12.55		0.53
0.03 to 5.55		0.50
0.03 to 4.89		0.47
0.03 to 6.72		0.44
0.02 to 5.55		0.43
0.03 to 4.71		0.40
0.01 to 10.59		0.41
0.02 to 5.21		0.35
0.01 to 17.98		0.33
0.01 to 16.37		0.34
0.02 to 3.58		0.33
0.01 to 6.46		0.34
0.02 to 3.28		0.33
0.01 to 6.83		0.30
0.02 to 3.36		0.25
0.01 to 2.98		0.24
0.02 to 2.73		0.23
0.01 to 3.91		0.21
0.00 to 11.27		0.21
0.00 to 9.20		0.20
0.01 to 3.65		0.20
0.01 to 3.62		0.18
0.01 to 1.40		0.16
0.00 to 9.02		0.15
0.01 to 1.11
DANU_PO_10MG_BID0.93
0.06 to 8.60		5.43
0.11 to 489		5.01
0.19 to 113		3.56
0.14 to 76.92		3.11
0.16 to 39.69		3.02
0.12 to 63.44		2.98
0.04 to 346		2.37
0.03 to 346		2.27
0.02 to 304		2.24
0.03 to 134		2.00
0.02 to 314		1.79
0.01 to 286		1.53
0.08 to 19.20		1.19
0.01 to 288		1.20
0.07 to 14.85		1.08
0.04 to 22.15		1.11
0.05 to 16.01		1.01
0.01 to 66.41		1.02
0.05 to 21.27		DANU_PO_10MG_BID1.01
0.06 to 10.13		0.92
0.02 to 27.39		0.88
0.05 to 10.08		0.81
0.03 to 13.30		0.81
0.05 to 8.65		0.82
0.05 to 7.98		0.79
0.05 to 8.92		0.79
0.05 to 9.57		0.78
0.05 to 7.89		0.77
0.05 to 8.14		0.78
0.04 to 10.79		0.79
0.02 to 24.48		0.75
0.04 to 9.46		0.77
0.04 to 9.95		0.74
0.04 to 9.99		0.73
0.04 to 8.80		0.77
0.03 to 21.92		0.72
0.04 to 8.31		0.68
0.04 to 7.77		0.68
0.04 to 7.36		0.65
0.04 to 7.30		0.65
0.02 to 12.19		0.63
0.04 to 5.87		0.59
0.04 to 6.00		0.57
0.03 to 6.87		0.55
0.02 to 10.89		0.54
0.03 to 5.62		0.51
0.03 to 4.98		0.49
0.02 to 6.35		0.47
0.02 to 5.43		0.44
0.02 to 4.88		0.41
0.01 to 9.66		0.42
0.02 to 5.23		0.35
0.01 to 16.42		0.35
0.01 to 15.95		0.36
0.02 to 3.54		0.34
0.01 to 5.92		0.34
0.02 to 3.45		0.33
0.01 to 6.88		0.31
0.02 to 3.24		0.25
0.01 to 3.00		0.26
0.02 to 2.65		0.24
0.01 to 3.67		0.21
0.00 to 10.99		0.21
0.00 to 9.52		0.21
0.01 to 3.47		0.21
0.01 to 3.41		0.18
0.01 to 1.39		0.16
0.00 to 10.63		0.15
0.01 to 1.06
SITAGLIPTIN0.94
0.51 to 1.62		5.35
0.27 to 324		5.07
0.77 to 42.87		3.59
0.56 to 28.69		3.09
1.21 to 8.26		3.00
0.55 to 23.81		3.01
0.10 to 198		2.35
0.06 to 242		2.28
0.05 to 168		2.27
0.08 to 74.17		2.02
0.05 to 180		1.87
0.03 to 172		1.53
0.45 to 5.10		1.25
0.01 to 165		1.18
0.42 to 3.44		1.12
0.15 to 9.05		1.10
0.33 to 3.90		1.05
0.03 to 33.23		1.02
0.10 to 15.78		0.99
0.10 to 16.17		SITAGLIPTIN0.89
0.08 to 12.85		0.89
0.29 to 2.64		0.82
0.16 to 4.41		0.82
0.40 to 1.57		0.81
0.42 to 1.47		0.80
0.33 to 1.93		0.79
0.25 to 2.50		0.79
0.38 to 1.43		0.78
0.40 to 1.39		0.77
0.19 to 3.32		0.75
0.10 to 11.33		0.75
0.23 to 2.23		0.75
0.24 to 2.29		0.74
0.19 to 3.03		0.73
0.21 to 2.23		0.73
0.10 to 10.96		0.72
0.26 to 2.01		0.69
0.21 to 2.04		0.69
0.33 to 1.32		0.66
0.22 to 1.85		0.65
0.10 to 4.19		0.63
0.32 to 1.12		0.58
0.24 to 1.38		0.57
0.17 to 1.74		0.56
0.07 to 4.48		0.55
0.24 to 1.13		0.51
0.27 to 0.89		0.49
0.13 to 1.80		0.45
0.13 to 1.65		0.45
0.17 to 1.03		0.42
0.03 to 4.41		0.42
0.12 to 1.49		0.36
0.02 to 8.57		0.36
0.02 to 8.04		0.36
0.20 to 0.60		0.35
0.05 to 2.33		0.33
0.04 to 2.50		0.33
0.05 to 2.80		0.31
0.13 to 0.69		0.25
0.09 to 0.70		0.26
0.13 to 0.46		0.25
0.04 to 1.22		0.22
0.01 to 5.54		0.21
0.01 to 4.91		0.20
0.04 to 1.34		0.20
0.04 to 1.21		0.18
0.02 to 1.12		0.17
0.00 to 5.46		0.15
0.02 to 0.87
DULA_SC_0p5MG_QW1.04
0.08 to 10.47		5.82
0.15 to 507		5.61
0.24 to 115		3.91
0.16 to 85.16		3.44
0.22 to 43.45		3.34
0.15 to 68.94		3.27
0.05 to 383		2.57
0.03 to 428		2.56
0.02 to 343		2.50
0.04 to 160		2.19
0.02 to 375		1.98
0.01 to 334		1.69
0.10 to 21.98		1.41
0.01 to 317		1.30
0.08 to 17.43		1.20
0.05 to 25.60		1.22
0.07 to 17.87		1.15
0.02 to 70.60		1.14
0.04 to 38.50		1.08
0.04 to 41.69		1.12
0.08 to 11.99		DULA_SC_0p5MG_QW0.96
0.06 to 11.75		0.89
0.05 to 15.74		0.90
0.06 to 10.05		0.88
0.06 to 9.54		0.88
0.06 to 10.14		0.87
0.05 to 10.79		0.87
0.06 to 8.82		0.85
0.06 to 9.38		0.86
0.04 to 12.72		0.86
0.03 to 28.86		0.82
0.05 to 10.18		0.83
0.05 to 10.85		0.81
0.05 to 11.66		0.80
0.05 to 9.56		0.85
0.03 to 28.72		0.80
0.05 to 9.49		0.76
0.05 to 9.22		0.75
0.05 to 8.02		0.73
0.05 to 8.54		0.73
0.03 to 13.05		0.69
0.05 to 7.18		0.65
0.04 to 7.00		0.63
0.04 to 8.06		0.61
0.02 to 12.44		0.59
0.04 to 6.58		0.56
0.04 to 5.78		0.54
0.03 to 7.67		0.51
0.03 to 6.87		0.49
0.03 to 5.35		0.46
0.01 to 12.26		0.47
0.03 to 6.02		0.39
0.01 to 20.50		0.38
0.01 to 19.64		0.39
0.03 to 4.10		0.38
0.02 to 7.10		0.37
0.01 to 7.81		0.36
0.02 to 8.00		0.34
0.02 to 3.70		0.28
0.02 to 3.37		0.28
0.02 to 3.08		0.26
0.01 to 4.25		0.24
0.00 to 12.29		0.24
0.00 to 10.21		0.23
0.01 to 4.16		0.23
0.01 to 3.92		0.19
0.01 to 3.65		0.18
0.00 to 11.71		0.16
0.01 to 2.72
EXEN_SC_2p5UG_BID1.07
0.41 to 2.72		6.05
0.27 to 393		5.77
0.73 to 55.00		4.10
0.53 to 37.57		3.51
0.82 to 15.54		3.40
0.51 to 31.91		3.36
0.10 to 231		2.70
0.07 to 265		2.64
0.05 to 215		2.57
0.09 to 90.20		2.32
0.05 to 212		2.14
0.03 to 199		1.74
0.39 to 7.74		1.43
0.01 to 211		1.34
0.31 to 6.02		1.29
0.14 to 11.29		1.26
0.25 to 6.93		1.20
0.04 to 39.06		1.18
0.10 to 20.39		1.14
0.10 to 21.93		1.13
0.38 to 3.48		1.04
0.09 to 16.95		EXEN_SC_2p5UG_BID0.93
0.14 to 6.48		0.92
0.30 to 2.72		0.92
0.31 to 2.68		0.90
0.26 to 3.32		0.88
0.22 to 3.74		0.88
0.29 to 2.67		0.88
0.28 to 2.72		0.87
0.16 to 4.84		0.88
0.10 to 14.19		0.83
0.20 to 3.63		0.85
0.19 to 3.91		0.84
0.18 to 4.29		0.82
0.20 to 3.14		0.85
0.10 to 13.48		0.81
0.22 to 3.07		0.78
0.20 to 2.96		0.78
0.25 to 2.32		0.74
0.20 to 2.76		0.73
0.09 to 5.89		0.71
0.25 to 1.89		0.66
0.20 to 2.17		0.65
0.15 to 2.75		0.62
0.07 to 5.92		0.62
0.23 to 1.60		0.58
0.22 to 1.49		0.56
0.12 to 2.49		0.52
0.12 to 2.26		0.51
0.15 to 1.54		0.48
0.03 to 5.97		0.49
0.11 to 2.07		0.40
0.02 to 10.66		0.40
0.02 to 9.88		0.40
0.14 to 1.16		0.40
0.05 to 2.94		0.38
0.04 to 3.29		0.38
0.05 to 3.63		0.35
0.11 to 1.08		0.29
0.08 to 1.11		0.29
0.09 to 0.88		0.28
0.04 to 1.63		0.24
0.01 to 6.97		0.25
0.01 to 5.97		0.23
0.04 to 1.76		0.24
0.04 to 1.70		0.20
0.03 to 1.43		0.19
0.01 to 6.66		0.16
0.02 to 1.13
LIRAMETF_SC_1p2-1500MG_QD1.15
0.21 to 5.88		6.74
0.23 to 501		6.32
0.58 to 74.31		4.45
0.44 to 47.70		3.81
0.55 to 25.10		3.69
0.47 to 36.88		3.72
0.09 to 323		2.93
0.06 to 347		2.94
0.05 to 288		2.78
0.07 to 130		2.53
0.04 to 261		2.24
0.03 to 263		1.88
0.25 to 13.37		1.55
0.01 to 230		1.43
0.26 to 7.99		1.36
0.10 to 17.49		1.35
0.20 to 9.30		1.29
0.03 to 57.48		1.25
0.07 to 28.42		1.23
0.08 to 29.75		1.22
0.23 to 6.13		1.12
0.06 to 21.84		1.08
0.15 to 7.20		LIRAMETF_SC_1p2-1500MG_QD0.98
0.17 to 5.43		0.99
0.17 to 5.22		0.97
0.16 to 6.05		0.97
0.13 to 6.36		0.96
0.17 to 4.96		0.96
0.19 to 4.53		0.94
0.11 to 7.87		0.96
0.07 to 19.28		0.92
0.12 to 5.77		0.92
0.14 to 6.11		0.90
0.11 to 7.29		0.88
0.12 to 6.03		0.93
0.07 to 19.20		0.88
0.13 to 5.70		0.83
0.12 to 5.51		0.83
0.14 to 4.57		0.81
0.12 to 4.98		0.79
0.07 to 8.05		0.76
0.14 to 4.00		0.71
0.11 to 4.27		0.69
0.10 to 4.70		0.67
0.05 to 9.41		0.66
0.11 to 3.60		0.62
0.11 to 3.24		0.60
0.08 to 4.50		0.56
0.07 to 4.04		0.54
0.08 to 3.16		0.51
0.03 to 8.69		0.51
0.07 to 3.85		0.44
0.01 to 14.44		0.43
0.01 to 13.31		0.44
0.08 to 2.17		0.42
0.04 to 5.29		0.41
0.03 to 5.29		0.40
0.04 to 5.52		0.38
0.06 to 2.09		0.31
0.05 to 2.07		0.31
0.06 to 1.54		0.30
0.03 to 2.64		0.26
0.01 to 9.16		0.25
0.01 to 8.22		0.25
0.03 to 2.86		0.25
0.02 to 2.74		0.22
0.02 to 2.48		0.20
0.00 to 8.67		0.18
0.01 to 1.84
TASP_SC_20MG_QW1.16
0.60 to 2.17		6.59
0.31 to 385		6.27
0.90 to 56.79		4.41
0.68 to 36.37		3.79
1.22 to 12.94		3.71
0.62 to 30.06		3.68
0.12 to 257		2.93
0.08 to 297		2.85
0.06 to 214		2.81
0.10 to 99.51		2.52
0.05 to 232		2.27
0.03 to 220		1.90
0.52 to 6.70		1.54
0.02 to 206		1.47
0.43 to 4.99		1.37
0.18 to 11.55		1.37
0.37 to 5.69		1.30
0.04 to 40.94		1.27
0.12 to 19.75		1.24
0.12 to 20.22		1.23
0.64 to 2.50		1.11
0.10 to 16.90		1.09
0.37 to 3.38		1.02
0.18 to 5.77		TASP_SC_20MG_QW0.99
0.48 to 2.13		0.97
0.36 to 2.79		0.97
0.29 to 3.36		0.96
0.43 to 2.11		0.95
0.41 to 2.20		0.95
0.23 to 4.44		0.95
0.12 to 14.82		0.92
0.28 to 3.06		0.93
0.27 to 3.39		0.91
0.23 to 3.86		0.90
0.27 to 2.84		0.90
0.12 to 14.51		0.89
0.30 to 2.60		0.84
0.26 to 2.54		0.84
0.47 to 1.47		0.81
0.25 to 2.46		0.81
0.12 to 5.41		0.77
0.37 to 1.52		0.72
0.28 to 1.82		0.70
0.21 to 2.33		0.68
0.10 to 5.36		0.67
0.30 to 1.49		0.63
0.34 to 1.14		0.61
0.16 to 2.27		0.56
0.15 to 2.10		0.55
0.21 to 1.32		0.52
0.04 to 5.44		0.52
0.14 to 1.90		0.45
0.02 to 10.64		0.44
0.02 to 10.43		0.44
0.21 to 0.90		0.43
0.07 to 2.73		0.41
0.06 to 3.24		0.41
0.07 to 3.56		0.38
0.15 to 0.91		0.31
0.11 to 0.94		0.31
0.14 to 0.71		0.30
0.05 to 1.57		0.26
0.01 to 7.07		0.26
0.01 to 6.08		0.26
0.05 to 1.68		0.25
0.05 to 1.55		0.22
0.03 to 1.39		0.21
0.01 to 6.95		0.18
0.03 to 1.08
DULA_SC_1p5MG_QW1.18
0.66 to 1.89		6.65
0.33 to 388		6.33
0.95 to 55.10		4.46
0.70 to 36.30		3.85
1.28 to 12.07		3.73
0.66 to 29.05		3.71
0.12 to 253		2.98
0.08 to 276		2.91
0.06 to 219		2.82
0.10 to 92.28		2.52
0.06 to 234		2.32
0.03 to 212		1.90
0.60 to 6.13		1.58
0.02 to 203		1.48
0.46 to 4.87		1.39
0.19 to 10.58		1.38
0.36 to 5.55		1.31
0.04 to 40.20		1.28
0.12 to 18.77		1.23
0.13 to 19.85		1.24
0.68 to 2.39		1.13
0.10 to 15.74		1.09
0.37 to 3.20		1.01
0.19 to 5.78		1.01
0.47 to 2.09		DULA_SC_1p5MG_QW0.99
0.40 to 2.51		0.99
0.32 to 2.90		0.97
0.56 to 1.64		0.96
0.47 to 1.94		0.95
0.24 to 4.08		0.94
0.12 to 14.26		0.93
0.30 to 2.67		0.94
0.27 to 3.34		0.92
0.24 to 3.80		0.91
0.26 to 2.79		0.92
0.13 to 13.74		0.90
0.32 to 2.57		0.85
0.27 to 2.52		0.85
0.38 to 1.80		0.83
0.28 to 2.24		0.81
0.13 to 5.24		0.78
0.41 to 1.37		0.72
0.30 to 1.71		0.71
0.23 to 2.17		0.69
0.09 to 5.54		0.68
0.31 to 1.38		0.64
0.35 to 1.11		0.62
0.16 to 2.22		0.57
0.16 to 2.03		0.56
0.21 to 1.31		0.53
0.05 to 5.03		0.53
0.15 to 1.81		0.45
0.02 to 10.46		0.44
0.02 to 9.84		0.44
0.26 to 0.73		0.43
0.06 to 2.91		0.42
0.06 to 3.12		0.41
0.07 to 3.41		0.38
0.16 to 0.86		0.32
0.12 to 0.87		0.32
0.17 to 0.59		0.31
0.05 to 1.48		0.27
0.01 to 6.65		0.27
0.01 to 5.88		0.26
0.05 to 1.65		0.26
0.05 to 1.53		0.22
0.03 to 1.36		0.21
0.01 to 6.69		0.18
0.03 to 1.02
LIRA_SC_0p9MG_QD1.18
0.46 to 2.83		6.75
0.30 to 423		6.39
0.84 to 59.71		4.56
0.63 to 39.01		3.86
1.08 to 14.54		3.78
0.57 to 32.26		3.72
0.12 to 255		2.91
0.08 to 306		2.93
0.06 to 242		2.87
0.10 to 100		2.55
0.05 to 228		2.39
0.03 to 226		1.94
0.49 to 7.37		1.56
0.02 to 206		1.48
0.40 to 5.61		1.39
0.16 to 12.72		1.39
0.32 to 6.46		1.33
0.04 to 45.46		1.28
0.11 to 21.72		1.26
0.11 to 20.99		1.25
0.52 to 3.08		1.13
0.10 to 17.83		1.11
0.30 to 3.92		1.03
0.17 to 6.37		1.03
0.36 to 2.80		1.01
0.40 to 2.53		LIRA_SC_0p9MG_QD0.99
0.27 to 3.55		0.98
0.38 to 2.42		0.97
0.35 to 2.52		0.97
0.20 to 4.68		0.96
0.11 to 14.84		0.94
0.24 to 3.40		0.95
0.23 to 3.88		0.93
0.20 to 4.45		0.91
0.23 to 3.40		0.91
0.11 to 15.32		0.91
0.29 to 2.61		0.86
0.22 to 3.14		0.85
0.31 to 2.33		0.84
0.21 to 2.86		0.82
0.11 to 6.12		0.78
0.30 to 1.95		0.73
0.26 to 1.93		0.72
0.18 to 2.69		0.69
0.08 to 6.31		0.69
0.24 to 1.86		0.64
0.25 to 1.54		0.62
0.14 to 2.61		0.57
0.13 to 2.48		0.56
0.17 to 1.65		0.53
0.04 to 6.17		0.53
0.12 to 2.27		0.45
0.02 to 11.22		0.45
0.02 to 10.30		0.45
0.18 to 1.09		0.43
0.06 to 3.35		0.42
0.05 to 3.61		0.41
0.06 to 3.91		0.39
0.13 to 1.05		0.32
0.10 to 1.09		0.32
0.12 to 0.83		0.31
0.05 to 1.79		0.27
0.01 to 7.60		0.27
0.01 to 6.59		0.26
0.04 to 1.84		0.26
0.04 to 1.81		0.22
0.03 to 1.56		0.21
0.01 to 6.96		0.18
0.02 to 1.23
SEMA_PO_7MG_QD1.19
0.39 to 3.52		6.77
0.29 to 435		6.54
0.76 to 64.72		4.54
0.56 to 42.86		3.94
0.89 to 17.73		3.86
0.53 to 35.76		3.83
0.12 to 290		3.06
0.08 to 302		2.96
0.06 to 242		2.91
0.10 to 103		2.57
0.05 to 261		2.37
0.03 to 238		1.94
0.72 to 5.19		1.61
0.02 to 220		1.48
0.34 to 7.21		1.41
0.15 to 15.06		1.38
0.28 to 7.66		1.36
0.04 to 44.80		1.34
0.10 to 23.12		1.26
0.10 to 21.97		1.27
0.40 to 4.03		1.15
0.09 to 19.69		1.13
0.27 to 4.64		1.03
0.16 to 7.67		1.03
0.30 to 3.45		1.01
0.34 to 3.11		1.01
0.28 to 3.74		SEMA_PO_7MG_QD0.99
0.38 to 2.55		0.98
0.30 to 3.23		0.98
0.19 to 5.42		0.98
0.10 to 15.79		0.95
0.37 to 2.30		0.95
0.20 to 4.59		0.94
0.18 to 4.98		0.93
0.20 to 3.95		0.95
0.10 to 15.70		0.92
0.22 to 3.61		0.87
0.20 to 3.72		0.87
0.25 to 2.86		0.85
0.19 to 3.40		0.83
0.10 to 6.70		0.79
0.24 to 2.42		0.73
0.20 to 2.74		0.72
0.17 to 3.10		0.70
0.07 to 7.02		0.69
0.20 to 2.24		0.65
0.20 to 1.90		0.63
0.12 to 3.15		0.58
0.12 to 2.87		0.57
0.14 to 2.02		0.54
0.04 to 6.33		0.54
0.10 to 2.74		0.46
0.02 to 12.37		0.46
0.02 to 11.67		0.45
0.15 to 1.30		0.44
0.05 to 3.58		0.43
0.05 to 3.97		0.42
0.05 to 4.55		0.39
0.11 to 1.39		0.32
0.08 to 1.32		0.32
0.10 to 1.00		0.31
0.04 to 2.18		0.27
0.01 to 8.39		0.28
0.01 to 7.06		0.27
0.04 to 2.09		0.26
0.04 to 1.98		0.22
0.03 to 1.73		0.21
0.01 to 7.61		0.18
0.02 to 1.32
DULA_SC_0p75MG_QW1.21
0.65 to 2.15		6.70
0.35 to 411		6.41
0.99 to 58.51		4.55
0.72 to 35.96		3.95
1.30 to 13.29		3.85
0.69 to 30.35		3.86
0.13 to 255		3.08
0.09 to 292		3.02
0.06 to 224		2.94
0.11 to 95.95		2.60
0.06 to 236		2.41
0.03 to 221		1.98
0.71 to 5.57		1.65
0.02 to 213		1.51
0.47 to 5.19		1.45
0.18 to 11.72		1.42
0.37 to 5.85		1.35
0.04 to 41.30		1.33
0.13 to 20.23		1.28
0.13 to 20.74		1.26
0.70 to 2.60		1.15
0.11 to 16.42		1.14
0.37 to 3.46		1.05
0.20 to 6.03		1.04
0.47 to 2.31		1.03
0.61 to 1.80		1.02
0.41 to 2.60		1.01
0.39 to 2.65		DULA_SC_0p75MG_QW0.99
0.47 to 2.14		0.99
0.25 to 4.34		0.98
0.12 to 14.83		0.96
0.37 to 2.48		0.97
0.28 to 3.47		0.95
0.24 to 3.98		0.93
0.28 to 3.04		0.95
0.13 to 13.79		0.92
0.32 to 2.69		0.88
0.28 to 2.65		0.88
0.40 to 1.92		0.85
0.28 to 2.45		0.84
0.13 to 5.57		0.80
0.40 to 1.53		0.74
0.30 to 1.88		0.73
0.24 to 2.29		0.71
0.09 to 5.73		0.70
0.31 to 1.50		0.65
0.34 to 1.23		0.63
0.17 to 2.41		0.59
0.16 to 2.19		0.57
0.21 to 1.41		0.55
0.05 to 5.41		0.55
0.15 to 2.00		0.46
0.02 to 11.40		0.46
0.02 to 10.45		0.45
0.27 to 0.78		0.44
0.07 to 3.08		0.43
0.06 to 3.28		0.43
0.07 to 3.69		0.39
0.17 to 0.94		0.33
0.12 to 0.95		0.32
0.17 to 0.63		0.32
0.05 to 1.58		0.28
0.01 to 7.26		0.28
0.01 to 6.28		0.27
0.05 to 1.81		0.26
0.05 to 1.63		0.23
0.03 to 1.48		0.21
0.01 to 7.07		0.19
0.03 to 1.09
LIRA_SC_1p8MG_QD1.22
0.61 to 2.29		6.94
0.35 to 399		6.55
1.06 to 55.25		4.61
0.74 to 34.87		3.99
1.32 to 13.21		3.87
0.74 to 30.74		3.88
0.13 to 267		3.06
0.09 to 315		2.95
0.07 to 224		2.95
0.11 to 99.63		2.61
0.06 to 237		2.41
0.03 to 226		1.98
0.57 to 6.84		1.62
0.02 to 215		1.52
0.51 to 4.92		1.44
0.18 to 11.87		1.43
0.39 to 5.78		1.36
0.05 to 42.79		1.33
0.12 to 20.87		1.30
0.12 to 21.75		1.28
0.72 to 2.48		1.18
0.11 to 16.66		1.14
0.37 to 3.57		1.04
0.22 to 5.39		1.05
0.45 to 2.41		1.04
0.52 to 2.13		1.03
0.40 to 2.83		1.02
0.31 to 3.36		1.01
0.47 to 2.13		LIRA_SC_1p8MG_QD0.99
0.25 to 4.40		1.00
0.12 to 15.30		0.97
0.28 to 3.12		0.97
0.29 to 3.37		0.96
0.23 to 4.05		0.94
0.27 to 3.16		0.95
0.13 to 13.94		0.93
0.32 to 2.75		0.88
0.27 to 2.81		0.89
0.38 to 1.98		0.86
0.27 to 2.58		0.85
0.14 to 5.05		0.82
0.38 to 1.60		0.75
0.29 to 1.94		0.74
0.23 to 2.36		0.72
0.09 to 6.31		0.71
0.30 to 1.59		0.66
0.32 to 1.28		0.64
0.16 to 2.47		0.59
0.16 to 2.23		0.58
0.20 to 1.43		0.55
0.04 to 5.75		0.55
0.14 to 2.01		0.47
0.02 to 11.41		0.47
0.02 to 10.42		0.46
0.24 to 0.85		0.45
0.06 to 3.04		0.44
0.06 to 3.51		0.43
0.07 to 3.69		0.40
0.16 to 0.97		0.33
0.12 to 0.97		0.33
0.17 to 0.66		0.32
0.05 to 1.66		0.28
0.01 to 7.35		0.28
0.01 to 6.40		0.27
0.05 to 1.79		0.27
0.05 to 1.64		0.23
0.03 to 1.50		0.22
0.01 to 7.20		0.19
0.03 to 1.13
BEIN_SC_0p2MG_TID1.22
0.28 to 4.69		6.98
0.26 to 472		6.45
0.67 to 78.28		4.68
0.48 to 50.34		4.08
0.70 to 22.25		3.93
0.44 to 43.16		3.97
0.10 to 296		3.17
0.07 to 345		2.97
0.05 to 271		2.96
0.08 to 125		2.65
0.05 to 283		2.39
0.03 to 252		1.97
0.33 to 10.85		1.63
0.01 to 230		1.52
0.28 to 8.84		1.46
0.12 to 15.95		1.42
0.23 to 9.68		1.37
0.04 to 53.52		1.33
0.09 to 27.51		1.29
0.09 to 27.39		1.29
0.30 to 5.25		1.16
0.08 to 22.30		1.14
0.21 to 6.19		1.06
0.13 to 9.02		1.05
0.23 to 4.44		1.05
0.25 to 4.25		1.03
0.21 to 5.00		1.02
0.18 to 5.25		1.01
0.23 to 4.00		1.01
0.23 to 4.04		BEIN_SC_0p2MG_TID1.02
0.08 to 18.22		0.96
0.17 to 5.12		0.97
0.17 to 5.75		0.95
0.14 to 6.62		0.95
0.16 to 4.96		0.97
0.09 to 17.68		0.93
0.18 to 4.77		0.88
0.16 to 4.53		0.87
0.19 to 3.72		0.85
0.15 to 4.29		0.85
0.09 to 8.22		0.81
0.19 to 3.18		0.75
0.15 to 3.47		0.74
0.15 to 3.65		0.71
0.07 to 8.31		0.70
0.16 to 3.02		0.66
0.15 to 2.61		0.64
0.10 to 3.92		0.59
0.10 to 3.50		0.58
0.11 to 2.57		0.54
0.03 to 7.83		0.55
0.09 to 3.14		0.46
0.02 to 13.33		0.46
0.02 to 13.42		0.46
0.12 to 1.67		0.45
0.05 to 4.42		0.43
0.04 to 4.75		0.43
0.04 to 5.07		0.40
0.08 to 1.79		0.33
0.06 to 1.69		0.33
0.07 to 1.29		0.32
0.03 to 2.40		0.28
0.01 to 8.16		0.28
0.01 to 8.20		0.27
0.03 to 2.38		0.27
0.03 to 2.41		0.23
0.02 to 1.99		0.22
0.00 to 8.57		0.18
0.02 to 1.59
LIXI_SC_10UG_BID1.24
0.09 to 8.51		6.97
0.14 to 635		6.56
0.27 to 117		4.65
0.20 to 77.75		4.05
0.24 to 41.43		3.89
0.17 to 63.15		3.80
0.05 to 407		3.04
0.04 to 392		2.94
0.03 to 367		2.81
0.05 to 166		2.57
0.02 to 344		2.29
0.02 to 353		1.99
0.12 to 19.51		1.59
0.01 to 297		1.54
0.09 to 15.39		1.39
0.06 to 24.10		1.44
0.07 to 16.30		1.31
0.02 to 70.53		1.33
0.04 to 37.38		1.27
0.04 to 41.18		1.33
0.09 to 10.34		1.17
0.03 to 33.65		1.14
0.07 to 10.38		1.04
0.05 to 14.76		1.05
0.07 to 8.47		1.07
0.07 to 8.02		1.04
0.07 to 9.36		1.02
0.06 to 9.66		1.02
0.07 to 8.12		1.00
0.07 to 8.17		0.98
0.05 to 11.89		LIXI_SC_10UG_BID0.97
0.06 to 9.40		0.99
0.05 to 10.16		0.94
0.05 to 10.79		0.95
0.05 to 8.70		0.98
0.05 to 19.80		0.93
0.06 to 8.16		0.89
0.05 to 7.94		0.89
0.06 to 7.21		0.86
0.05 to 7.43		0.84
0.03 to 12.39		0.82
0.06 to 5.98		0.76
0.05 to 6.35		0.73
0.04 to 7.31		0.71
0.03 to 12.72		0.72
0.05 to 5.56		0.67
0.05 to 4.82		0.63
0.03 to 6.53		0.60
0.04 to 4.57		0.57
0.04 to 4.78		0.52
0.01 to 12.05		0.55
0.04 to 4.44		0.46
0.01 to 17.27		0.45
0.01 to 18.97		0.47
0.03 to 3.47		0.44
0.02 to 6.58		0.43
0.02 to 6.87		0.43
0.02 to 5.46		0.40
0.03 to 3.18		0.33
0.02 to 3.03		0.33
0.02 to 2.60		0.31
0.01 to 3.87		0.28
0.01 to 11.72		0.26
0.01 to 11.05		0.28
0.02 to 2.70		0.27
0.02 to 2.51		0.23
0.01 to 3.26		0.21
0.00 to 11.70		0.19
0.01 to 2.52
SEMA_PO_14MG_QD1.25
0.42 to 3.74		7.23
0.31 to 455		6.83
0.78 to 73.23		4.83
0.59 to 46.24		4.14
1.01 to 19.10		4.12
0.56 to 37.03		4.12
0.12 to 298		3.23
0.09 to 303		3.15
0.06 to 250		3.05
0.10 to 115		2.72
0.05 to 265		2.49
0.03 to 243		2.06
0.79 to 5.39		1.72
0.02 to 220		1.60
0.36 to 7.57		1.50
0.16 to 14.92		1.47
0.29 to 8.34		1.42
0.04 to 48.51		1.40
0.11 to 24.51		1.34
0.11 to 23.51		1.33
0.45 to 4.39		1.21
0.10 to 20.35		1.20
0.28 to 4.93		1.09
0.17 to 8.27		1.09
0.33 to 3.61		1.08
0.38 to 3.32		1.06
0.29 to 4.14		1.05
0.43 to 2.68		1.04
0.40 to 2.72		1.03
0.32 to 3.51		1.04
0.20 to 6.01		1.03
0.11 to 17.48		SEMA_PO_14MG_QD1.01
0.22 to 4.88		1.00
0.19 to 5.49		0.98
0.20 to 4.30		1.00
0.11 to 16.85		0.97
0.24 to 3.94		0.91
0.21 to 3.82		0.91
0.27 to 3.10		0.89
0.21 to 3.61		0.88
0.11 to 6.91		0.83
0.26 to 2.58		0.78
0.22 to 2.93		0.76
0.19 to 3.19		0.74
0.08 to 7.80		0.72
0.22 to 2.39		0.68
0.23 to 2.05		0.66
0.13 to 3.32		0.62
0.12 to 3.08		0.59
0.15 to 2.14		0.57
0.04 to 6.97		0.57
0.12 to 2.89		0.48
0.02 to 13.50		0.48
0.02 to 12.52		0.47
0.17 to 1.37		0.47
0.06 to 3.96		0.46
0.05 to 4.14		0.45
0.06 to 4.62		0.41
0.12 to 1.45		0.34
0.09 to 1.38		0.34
0.11 to 1.09		0.33
0.04 to 2.18		0.29
0.01 to 8.16		0.29
0.01 to 7.54		0.28
0.04 to 2.21		0.28
0.04 to 2.12		0.24
0.03 to 1.81		0.23
0.01 to 7.94		0.20
0.02 to 1.39
EXENER_SC_2MG_QW1.25
0.36 to 4.10		7.22
0.27 to 511		6.79
0.79 to 70.12		4.81
0.57 to 47.73		4.09
1.01 to 18.11		4.01
0.57 to 38.23		4.01
0.12 to 284		3.17
0.08 to 326		3.04
0.06 to 270		3.06
0.09 to 120		2.74
0.05 to 264		2.51
0.03 to 240		2.01
0.41 to 10.31		1.70
0.02 to 256		1.56
0.54 to 4.69		1.48
0.15 to 16.43		1.48
0.44 to 5.08		1.42
0.04 to 54.49		1.38
0.10 to 24.92		1.31
0.10 to 25.82		1.33
0.44 to 4.17		1.20
0.09 to 20.21		1.18
0.26 to 5.23		1.09
0.16 to 7.31		1.07
0.30 to 3.76		1.06
0.30 to 3.75		1.06
0.26 to 4.40		1.05
0.22 to 5.02		1.03
0.29 to 3.54		1.03
0.30 to 3.49		1.03
0.17 to 6.02		1.01
0.10 to 18.62		0.99
0.20 to 4.63		EXENER_SC_2MG_QW0.99
0.18 to 5.56		0.97
0.19 to 4.43		0.99
0.10 to 17.20		0.95
0.22 to 4.09		0.92
0.18 to 4.08		0.91
0.24 to 3.18		0.88
0.18 to 3.95		0.86
0.10 to 7.75		0.83
0.24 to 2.76		0.78
0.19 to 3.01		0.75
0.15 to 3.63		0.74
0.07 to 7.71		0.73
0.19 to 2.59		0.68
0.19 to 2.24		0.65
0.12 to 3.49		0.61
0.11 to 3.18		0.59
0.14 to 2.28		0.56
0.04 to 7.51		0.56
0.11 to 2.92		0.48
0.02 to 12.84		0.48
0.02 to 11.95		0.47
0.14 to 1.56		0.46
0.05 to 4.05		0.44
0.05 to 4.26		0.44
0.05 to 4.71		0.41
0.10 to 1.53		0.34
0.08 to 1.45		0.33
0.10 to 1.15		0.33
0.04 to 2.29		0.28
0.01 to 8.45		0.28
0.01 to 7.58		0.28
0.04 to 2.20		0.27
0.04 to 2.19		0.24
0.03 to 1.93		0.22
0.01 to 8.31		0.19
0.02 to 1.53
ROSIGLITAZONE1.27
0.32 to 4.51		7.48
0.28 to 469		6.74
0.73 to 79.99		4.85
0.52 to 51.78		4.16
0.77 to 22.50		4.04
0.48 to 42.00		4.09
0.11 to 323		3.26
0.07 to 313		3.15
0.06 to 269		3.08
0.09 to 123		2.68
0.05 to 290		2.49
0.03 to 263		2.08
0.37 to 11.59		1.71
0.02 to 248		1.58
0.29 to 8.94		1.50
0.14 to 16.15		1.51
0.25 to 9.29		1.42
0.04 to 51.37		1.41
0.09 to 25.70		1.35
0.10 to 27.32		1.34
0.33 to 5.22		1.23
0.09 to 21.73		1.19
0.23 to 5.66		1.11
0.14 to 9.08		1.10
0.26 to 4.30		1.09
0.26 to 4.18		1.07
0.22 to 4.93		1.06
0.20 to 5.65		1.05
0.25 to 4.24		1.05
0.25 to 4.27		1.05
0.15 to 7.18		1.07
0.09 to 20.84		1.00
0.18 to 5.18		1.01
0.18 to 5.62		ROSIGLITAZONE0.98
0.19 to 4.79		1.01
0.10 to 18.30		0.97
0.20 to 4.60		0.92
0.17 to 4.51		0.92
0.22 to 3.62		0.89
0.18 to 4.17		0.87
0.09 to 8.36		0.84
0.21 to 3.05		0.78
0.18 to 3.29		0.76
0.14 to 3.89		0.76
0.07 to 8.63		0.74
0.18 to 2.76		0.69
0.18 to 2.36		0.67
0.18 to 2.37		0.61
0.11 to 3.47		0.60
0.13 to 2.51		0.57
0.04 to 7.71		0.57
0.10 to 3.26		0.48
0.02 to 14.51		0.49
0.02 to 12.90		0.47
0.12 to 1.84		0.46
0.05 to 4.54		0.46
0.04 to 4.85		0.45
0.05 to 5.16		0.42
0.10 to 1.65		0.34
0.07 to 1.58		0.34
0.08 to 1.39		0.32
0.04 to 2.47		0.29
0.01 to 8.94		0.28
0.01 to 7.75		0.28
0.04 to 2.42		0.28
0.04 to 2.37		0.24
0.02 to 2.19		0.22
0.01 to 8.60		0.20
0.02 to 1.68
IGLARLIXI2_SC_TIT_QD1.29
0.46 to 3.80		7.41
0.33 to 510		6.92
0.85 to 70.78		4.96
0.63 to 47.11		4.21
1.00 to 20.48		4.18
0.57 to 39.45		4.20
0.13 to 303		3.33
0.08 to 323		3.22
0.06 to 270		3.16
0.11 to 113		2.80
0.06 to 292		2.56
0.03 to 273		2.11
0.45 to 10.23		1.74
0.02 to 258		1.61
0.38 to 8.19		1.56
0.17 to 15.20		1.50
0.31 to 9.25		1.45
0.05 to 53.57		1.44
0.11 to 25.82		1.38
0.11 to 27.15		1.37
0.45 to 4.82		1.25
0.10 to 20.29		1.23
0.32 to 5.01		1.13
0.17 to 8.39		1.11
0.35 to 3.76		1.10
0.36 to 3.78		1.10
0.29 to 4.33		1.07
0.25 to 5.05		1.08
0.33 to 3.55		1.07
0.32 to 3.74		1.05
0.20 to 6.33		1.06
0.11 to 19.14		1.02
0.23 to 4.95		1.03
0.23 to 5.33		1.02
0.21 to 5.22		IGLARLIXI2_SC_TIT_QD1.02
0.11 to 18.15		0.98
0.26 to 4.01		0.94
0.23 to 3.94		0.93
0.29 to 3.14		0.90
0.24 to 3.73		0.91
0.11 to 7.62		0.86
0.30 to 2.56		0.80
0.24 to 2.84		0.78
0.18 to 3.67		0.77
0.08 to 7.58		0.75
0.23 to 2.37		0.69
0.26 to 1.94		0.68
0.15 to 3.25		0.63
0.14 to 3.15		0.61
0.29 to 1.31		0.58
0.04 to 7.41		0.58
0.13 to 2.83		0.50
0.02 to 14.33		0.50
0.02 to 12.65		0.48
0.16 to 1.62		0.48
0.06 to 4.04		0.46
0.05 to 4.38		0.45
0.06 to 4.67		0.42
0.14 to 1.43		0.35
0.09 to 1.40		0.34
0.11 to 1.25		0.34
0.05 to 2.29		0.30
0.01 to 8.61		0.30
0.01 to 7.64		0.29
0.04 to 2.31		0.28
0.04 to 2.17		0.25
0.03 to 1.85		0.23
0.01 to 7.98		0.20
0.02 to 1.45
LIXI_SC_5UG_QD1.29
0.09 to 8.62		6.96
0.14 to 655		6.56
0.28 to 123		4.66
0.21 to 82.94		4.11
0.25 to 38.41		4.01
0.19 to 68.95		3.90
0.06 to 377		3.11
0.04 to 390		3.04
0.03 to 343		2.88
0.05 to 158		2.61
0.03 to 351		2.39
0.02 to 355		2.01
0.12 to 19.38		1.63
0.01 to 308		1.56
0.09 to 15.00		1.48
0.06 to 25.16		1.50
0.08 to 16.30		1.33
0.02 to 73.05		1.38
0.04 to 38.84		1.30
0.05 to 39.83		1.37
0.09 to 9.86		1.18
0.03 to 29.07		1.18
0.07 to 10.18		1.07
0.05 to 14.44		1.11
0.07 to 8.40		1.09
0.07 to 7.88		1.10
0.07 to 9.06		1.05
0.06 to 9.64		1.06
0.07 to 7.75		1.05
0.07 to 7.73		1.03
0.06 to 11.12		1.02
0.05 to 20.82		1.00
0.06 to 9.27		1.01
0.06 to 9.87		0.99
0.05 to 10.46		0.98
0.06 to 8.91		LIXI_SC_5UG_QD0.96
0.06 to 8.11		0.92
0.05 to 8.16		0.92
0.06 to 7.00		0.88
0.05 to 7.13		0.85
0.04 to 12.74		0.86
0.06 to 5.94		0.78
0.05 to 6.14		0.76
0.05 to 6.92		0.73
0.03 to 12.63		0.73
0.05 to 5.35		0.69
0.05 to 4.81		0.66
0.04 to 6.29		0.61
0.04 to 4.81		0.60
0.04 to 4.51		0.54
0.02 to 11.76		0.57
0.04 to 4.77		0.47
0.01 to 18.84		0.45
0.01 to 18.98		0.48
0.03 to 3.49		0.45
0.02 to 6.89		0.44
0.02 to 6.95		0.43
0.03 to 5.42		0.42
0.03 to 3.19		0.34
0.02 to 2.88		0.34
0.02 to 2.62		0.32
0.01 to 4.17		0.28
0.01 to 13.24		0.27
0.01 to 10.78		0.28
0.02 to 2.70		0.28
0.02 to 2.66		0.24
0.01 to 3.26		0.21
0.00 to 12.14		0.19
0.01 to 2.54
ALBI_SC_30MG_QW1.31
0.51 to 3.22		7.53
0.33 to 458		7.08
0.90 to 68.04		4.99
0.67 to 45.64		4.34
1.06 to 17.75		4.20
0.65 to 38.07		4.23
0.12 to 282		3.35
0.09 to 320		3.26
0.07 to 252		3.18
0.11 to 112		2.78
0.06 to 269		2.59
0.04 to 249		2.16
0.50 to 9.17		1.75
0.02 to 262		1.65
0.40 to 6.84		1.55
0.18 to 14.22		1.55
0.33 to 7.75		1.45
0.05 to 49.55		1.44
0.12 to 23.71		1.38
0.12 to 23.56		1.39
0.50 to 3.82		1.25
0.11 to 19.50		1.23
0.33 to 4.48		1.14
0.18 to 7.43		1.12
0.39 to 3.31		1.12
0.39 to 3.16		1.10
0.38 to 3.43		1.09
0.28 to 4.49		1.09
0.37 to 3.08		1.08
0.36 to 3.12		1.07
0.21 to 5.58		1.08
0.12 to 17.96		1.04
0.25 to 4.19		1.06
0.24 to 4.60		1.03
0.22 to 5.00		1.02
0.25 to 3.80		1.04
0.12 to 16.41		ALBI_SC_30MG_QW0.96
0.24 to 3.47		0.95
0.32 to 2.77		0.92
0.24 to 3.34		0.92
0.12 to 7.45		0.87
0.32 to 2.23		0.81
0.34 to 1.89		0.80
0.20 to 3.22		0.77
0.09 to 6.81		0.76
0.26 to 2.07		0.71
0.27 to 1.79		0.69
0.15 to 3.10		0.64
0.15 to 2.89		0.62
0.18 to 1.95		0.60
0.04 to 6.75		0.59
0.14 to 2.47		0.50
0.02 to 13.23		0.50
0.02 to 11.79		0.50
0.18 to 1.35		0.48
0.06 to 3.67		0.47
0.05 to 3.93		0.46
0.07 to 4.52		0.43
0.16 to 1.14		0.35
0.11 to 1.25		0.35
0.12 to 1.04		0.34
0.05 to 1.97		0.30
0.01 to 8.61		0.30
0.01 to 7.10		0.29
0.05 to 2.18		0.29
0.05 to 2.03		0.25
0.03 to 1.76		0.24
0.01 to 8.03		0.20
0.03 to 1.35
VISEPE_SC_150UG_QW1.36
0.52 to 3.62		7.94
0.36 to 521		7.40
0.95 to 75.53		5.20
0.66 to 47.17		4.49
1.11 to 20.17		4.40
0.63 to 40.83		4.47
0.14 to 294		3.52
0.09 to 344		3.44
0.06 to 262		3.34
0.11 to 123		3.05
0.06 to 292		2.69
0.04 to 274		2.22
0.49 to 10.87		1.86
0.02 to 276		1.72
0.41 to 8.12		1.62
0.19 to 15.44		1.60
0.34 to 8.98		1.52
0.05 to 51.68		1.53
0.13 to 24.88		1.46
0.13 to 27.32		1.45
0.49 to 4.71		1.31
0.11 to 20.30		1.28
0.34 to 5.08		1.20
0.18 to 8.62		1.18
0.39 to 3.81		1.18
0.40 to 3.64		1.16
0.32 to 4.48		1.14
0.27 to 5.09		1.14
0.38 to 3.56		1.13
0.36 to 3.68		1.14
0.22 to 6.25		1.13
0.13 to 19.08		1.10
0.26 to 4.81		1.09
0.25 to 5.42		1.08
0.22 to 5.85		1.06
0.25 to 4.38		1.09
0.12 to 18.41		1.05
0.29 to 4.14		VISEPE_SC_150UG_QW0.99
0.32 to 3.20		0.97
0.25 to 3.67		0.95
0.12 to 7.86		0.91
0.33 to 2.51		0.84
0.25 to 2.95		0.82
0.20 to 3.68		0.80
0.09 to 7.93		0.79
0.26 to 2.40		0.75
0.27 to 2.12		0.71
0.16 to 3.60		0.67
0.15 to 3.01		0.65
0.19 to 2.24		0.61
0.04 to 7.48		0.62
0.14 to 2.84		0.53
0.02 to 12.95		0.52
0.02 to 12.67		0.52
0.18 to 1.57		0.50
0.06 to 4.11		0.49
0.06 to 4.22		0.48
0.07 to 4.81		0.45
0.14 to 1.53		0.37
0.10 to 1.52		0.37
0.12 to 1.22		0.36
0.05 to 2.17		0.32
0.01 to 9.34		0.32
0.01 to 7.36		0.30
0.05 to 2.30		0.30
0.05 to 2.14		0.26
0.03 to 1.91		0.25
0.01 to 9.27		0.21
0.03 to 1.46
TASP_SC_10MG_QW1.38
0.71 to 2.62		7.92
0.38 to 468		7.41
1.09 to 65.67		5.26
0.79 to 42.78		4.53
1.48 to 15.62		4.42
0.75 to 36.15		4.43
0.15 to 308		3.51
0.10 to 332		3.45
0.07 to 258		3.34
0.12 to 111		2.96
0.07 to 280		2.74
0.04 to 258		2.25
0.64 to 8.16		1.85
0.02 to 249		1.73
0.52 to 6.10		1.63
0.21 to 13.47		1.64
0.42 to 6.82		1.55
0.05 to 46.07		1.52
0.14 to 24.02		1.47
0.14 to 24.88		1.46
0.76 to 3.03		1.33
0.12 to 19.38		1.28
0.43 to 4.05		1.20
0.22 to 7.11		1.19
0.68 to 2.14		1.17
0.56 to 2.66		1.17
0.43 to 3.27		1.15
0.35 to 4.03		1.14
0.52 to 2.52		1.13
0.50 to 2.62		1.14
0.27 to 5.30		1.12
0.14 to 17.36		1.10
0.32 to 3.69		1.10
0.31 to 4.10		1.09
0.28 to 4.56		1.08
0.32 to 3.44		1.09
0.14 to 16.14		1.05
0.36 to 3.15		1.01
0.31 to 3.14		TASP_SC_10MG_QW0.97
0.32 to 2.90		0.98
0.14 to 6.50		0.92
0.44 to 1.83		0.85
0.34 to 2.18		0.83
0.26 to 2.79		0.81
0.11 to 6.45		0.80
0.35 to 1.77		0.75
0.41 to 1.38		0.73
0.19 to 2.77		0.67
0.19 to 2.48		0.66
0.25 to 1.63		0.61
0.05 to 6.42		0.62
0.17 to 2.35		0.53
0.03 to 12.43		0.52
0.02 to 12.19		0.52
0.26 to 1.06		0.51
0.08 to 3.39		0.50
0.07 to 3.84		0.48
0.08 to 4.19		0.45
0.19 to 1.10		0.37
0.13 to 1.11		0.37
0.17 to 0.86		0.36
0.06 to 1.98		0.32
0.02 to 8.41		0.32
0.02 to 7.25		0.31
0.06 to 1.94		0.31
0.06 to 1.89		0.26
0.04 to 1.67		0.25
0.01 to 8.21		0.21
0.03 to 1.29
SEMA_SC_2p4MG_QW1.42
0.59 to 3.58		8.10
0.38 to 511		7.81
0.98 to 75.73		5.55
0.73 to 49.67		4.68
1.19 to 21.23		4.61
0.67 to 40.71		4.66
0.14 to 311		3.67
0.09 to 343		3.50
0.07 to 288		3.49
0.11 to 124		3.11
0.07 to 297		2.83
0.04 to 272		2.32
0.53 to 10.26		1.95
0.02 to 274		1.77
0.44 to 8.01		1.69
0.20 to 14.88		1.70
0.35 to 8.78		1.57
0.05 to 55.30		1.58
0.14 to 27.54		1.54
0.14 to 27.95		1.50
0.54 to 4.65		1.37
0.12 to 22.04		1.35
0.36 to 5.07		1.24
0.20 to 8.12		1.23
0.41 to 3.97		1.21
0.45 to 3.52		1.20
0.35 to 4.65		1.18
0.29 to 5.18		1.18
0.41 to 3.60		1.17
0.39 to 3.65		1.18
0.23 to 6.45		1.16
0.13 to 18.71		1.13
0.28 to 4.77		1.13
0.25 to 5.45		1.13
0.24 to 5.71		1.11
0.27 to 4.15		1.14
0.14 to 18.38		1.09
0.30 to 4.09		1.04
0.27 to 3.95		1.03
0.35 to 3.16		SEMA_SC_2p4MG_QW0.98
0.13 to 8.08		0.94
0.36 to 2.55		0.88
0.27 to 3.04		0.86
0.21 to 3.66		0.84
0.09 to 7.84		0.82
0.28 to 2.41		0.77
0.30 to 2.08		0.74
0.17 to 3.43		0.69
0.16 to 3.06		0.67
0.20 to 2.17		0.65
0.04 to 7.85		0.64
0.15 to 2.88		0.55
0.02 to 13.59		0.54
0.02 to 13.76		0.54
0.19 to 1.55		0.52
0.07 to 3.95		0.52
0.06 to 4.29		0.50
0.08 to 4.73		0.46
0.15 to 1.51		0.39
0.11 to 1.48		0.39
0.13 to 1.21		0.38
0.05 to 2.19		0.33
0.02 to 9.76		0.32
0.01 to 7.72		0.31
0.05 to 2.33		0.31
0.05 to 2.23		0.27
0.03 to 1.94		0.25
0.01 to 8.44		0.22
0.03 to 1.46
CANALIRA_SC_1p8-300MG_QD1.43
0.23 to 8.90		8.46
0.24 to 646		7.74
0.76 to 97.13		5.50
0.51 to 66.57		4.73
0.59 to 39.00		4.67
0.45 to 56.59		4.69
0.10 to 418		3.72
0.06 to 482		3.60
0.05 to 364		3.63
0.08 to 167		3.18
0.05 to 383		2.93
0.03 to 375		2.30
0.28 to 19.72		1.92
0.02 to 332		1.80
0.23 to 14.67		1.70
0.12 to 25.87		1.72
0.19 to 15.44		1.66
0.03 to 77.48		1.58
0.07 to 45.18		1.55
0.08 to 45.55		1.53
0.24 to 9.99		1.37
0.08 to 32.91		1.36
0.17 to 10.61		1.26
0.12 to 13.92		1.24
0.18 to 8.45		1.23
0.19 to 7.87		1.21
0.16 to 9.25		1.21
0.15 to 10.11		1.19
0.18 to 7.94		1.17
0.20 to 7.12		1.18
0.12 to 11.51		1.19
0.08 to 29.66		1.13
0.14 to 9.52		1.17
0.13 to 9.72		1.15
0.12 to 11.01		1.10
0.13 to 9.12		1.18
0.08 to 26.32		1.09
0.13 to 8.57		1.05
0.13 to 8.18		1.02
0.15 to 7.13		1.02
0.12 to 7.79		CANALIRA_SC_1p8-300MG_QD0.95
0.15 to 6.12		0.88
0.13 to 6.57		0.86
0.11 to 7.29		0.84
0.06 to 13.35		0.82
0.12 to 5.45		0.78
0.12 to 4.99		0.76
0.08 to 6.80		0.69
0.08 to 6.11		0.68
0.09 to 4.88		0.64
0.03 to 12.07		0.65
0.07 to 5.82		0.55
0.02 to 21.86		0.54
0.02 to 18.84		0.54
0.08 to 3.48		0.53
0.04 to 7.16		0.52
0.04 to 7.64		0.52
0.04 to 8.68		0.47
0.07 to 3.36		0.39
0.05 to 2.91		0.39
0.06 to 2.55		0.37
0.03 to 4.13		0.32
0.01 to 14.33		0.33
0.01 to 12.34		0.32
0.03 to 4.27		0.31
0.03 to 4.18		0.27
0.02 to 3.53		0.26
0.01 to 11.54		0.22
0.02 to 2.74
LIXI_SC_20UG_QD1.50
1.09 to 2.10		8.60
0.43 to 500		8.14
1.26 to 71.14		5.75
0.92 to 44.30		4.91
1.69 to 15.93		4.82
0.92 to 38.00		4.87
0.17 to 321		3.84
0.11 to 361		3.80
0.08 to 282		3.68
0.14 to 113		3.28
0.07 to 277		3.00
0.04 to 278		2.47
0.76 to 8.34		2.04
0.02 to 276		1.89
0.61 to 6.58		1.79
0.25 to 13.59		1.77
0.49 to 7.47		1.68
0.06 to 51.20		1.65
0.17 to 24.68		1.59
0.17 to 26.18		1.58
0.89 to 3.14		1.46
0.14 to 19.63		1.40
0.53 to 3.96		1.32
0.25 to 7.35		1.29
0.66 to 2.68		1.27
0.73 to 2.46		1.28
0.51 to 3.38		1.26
0.41 to 4.10		1.24
0.65 to 2.51		1.23
0.62 to 2.63		1.24
0.31 to 5.39		1.22
0.17 to 17.26		1.20
0.39 to 3.82		1.21
0.36 to 4.25		1.19
0.33 to 4.82		1.17
0.39 to 3.39		1.17
0.17 to 17.02		1.15
0.45 to 3.09		1.10
0.40 to 2.99		1.09
0.55 to 2.28		1.07
0.39 to 2.74		1.05
0.16 to 6.87		LIXI_SC_20UG_QD0.93
0.42 to 2.15		0.91
0.29 to 2.94		0.90
0.12 to 6.90		0.87
0.47 to 1.63		0.82
0.53 to 1.30		0.79
0.23 to 2.89		0.73
0.22 to 2.50		0.71
0.31 to 1.55		0.69
0.05 to 6.87		0.68
0.21 to 2.24		0.58
0.03 to 12.98		0.57
0.03 to 12.02		0.57
0.32 to 1.06		0.56
0.09 to 3.60		0.54
0.07 to 3.89		0.52
0.09 to 4.20		0.49
0.23 to 1.08		0.41
0.16 to 1.13		0.40
0.21 to 0.85		0.39
0.07 to 1.93		0.35
0.02 to 8.65		0.34
0.02 to 7.41		0.33
0.07 to 1.95		0.33
0.07 to 1.89		0.29
0.04 to 1.63		0.27
0.01 to 8.68		0.23
0.04 to 1.28
ALBI_SC_50MG_QW1.61
0.74 to 3.41		9.17
0.43 to 527		8.70
1.25 to 80.19		6.17
0.89 to 51.78		5.33
1.44 to 19.18		5.22
0.86 to 44.11		5.15
0.16 to 338		4.04
0.11 to 407		3.99
0.08 to 322		3.93
0.14 to 131		3.53
0.08 to 314		3.20
0.05 to 300		2.63
0.67 to 10.04		2.13
0.02 to 312		2.03
0.56 to 7.77		1.93
0.24 to 16.13		1.90
0.44 to 8.70		1.79
0.06 to 57.27		1.77
0.16 to 28.12		1.70
0.17 to 28.56		1.71
0.73 to 4.20		1.55
0.14 to 23.85		1.52
0.46 to 5.01		1.41
0.23 to 8.81		1.40
0.55 to 3.53		1.38
0.58 to 3.35		1.36
0.52 to 3.81		1.36
0.37 to 5.03		1.35
0.53 to 3.28		1.33
0.52 to 3.48		1.33
0.29 to 6.57		1.31
0.16 to 20.79		1.28
0.34 to 4.64		1.27
0.33 to 5.35		1.28
0.30 to 5.63		1.25
0.35 to 4.25		1.28
0.16 to 18.95		1.23
0.53 to 2.91		1.19
0.34 to 4.01		1.18
0.46 to 2.91		1.14
0.33 to 3.66		1.13
0.15 to 7.98		1.07
0.47 to 2.38		ALBI_SC_50MG_QW0.97
0.27 to 3.50		0.96
0.12 to 8.07		0.94
0.37 to 2.23		0.87
0.41 to 1.86		0.85
0.21 to 3.40		0.77
0.20 to 3.14		0.77
0.26 to 2.05		0.73
0.05 to 7.87		0.72
0.18 to 2.86		0.63
0.03 to 15.16		0.62
0.03 to 13.06		0.61
0.26 to 1.44		0.59
0.08 to 4.30		0.58
0.07 to 4.59		0.56
0.09 to 5.18		0.53
0.27 to 1.01		0.44
0.15 to 1.27		0.43
0.17 to 1.09		0.42
0.07 to 2.27		0.37
0.02 to 10.28		0.37
0.02 to 8.65		0.36
0.06 to 2.54		0.35
0.06 to 2.24		0.31
0.04 to 2.03		0.29
0.01 to 9.54		0.25
0.04 to 1.60
SEMA_SC_2p0MG_QW1.65
0.54 to 4.84		9.34
0.40 to 632		8.98
1.10 to 95.27		6.33
0.80 to 62.68		5.45
1.27 to 24.86		5.23
0.76 to 50.53		5.26
0.15 to 375		4.12
0.11 to 428		4.11
0.08 to 361		4.00
0.13 to 146		3.57
0.06 to 349		3.30
0.04 to 331		2.71
0.58 to 12.24		2.19
0.02 to 322		2.05
0.48 to 9.81		1.95
0.21 to 18.61		1.95
0.39 to 11.02		1.86
0.05 to 66.33		1.82
0.14 to 33.35		1.75
0.15 to 32.55		1.75
0.57 to 5.77		1.59
0.12 to 26.57		1.55
0.36 to 6.69		1.44
0.21 to 10.32		1.43
0.43 to 4.73		1.41
0.46 to 4.30		1.40
0.37 to 5.63		1.39
0.32 to 5.85		1.37
0.44 to 4.11		1.36
0.42 to 4.36		1.36
0.27 to 6.82		1.37
0.14 to 22.38		1.32
0.31 to 5.38		1.33
0.28 to 6.59		1.31
0.26 to 7.33		1.29
0.27 to 5.52		1.31
0.14 to 22.14		1.25
0.31 to 5.03		1.22
0.27 to 4.92		1.20
0.36 to 3.91		1.16
0.27 to 4.78		1.16
0.14 to 9.15		1.10
0.34 to 3.41		1.03
0.29 to 3.69		SEMA_SC_2p0MG_QW0.97
0.11 to 9.35		0.95
0.28 to 3.18		0.90
0.29 to 2.68		0.87
0.18 to 4.37		0.81
0.16 to 4.09		0.79
0.20 to 2.71		0.76
0.05 to 8.71		0.75
0.15 to 3.65		0.63
0.03 to 16.85		0.62
0.02 to 15.66		0.63
0.23 to 1.71		0.61
0.08 to 5.01		0.59
0.06 to 5.62		0.58
0.07 to 6.07		0.54
0.15 to 1.87		0.44
0.11 to 1.88		0.45
0.14 to 1.39		0.43
0.06 to 2.72		0.38
0.02 to 10.88		0.38
0.02 to 9.69		0.37
0.05 to 2.89		0.36
0.05 to 2.84		0.32
0.04 to 2.37		0.29
0.01 to 10.43		0.25
0.03 to 1.83
TASP_SC_40MG_QW1.69
0.23 to 11.90		9.92
0.28 to 807		9.29
0.60 to 170		6.58
0.41 to 105		5.55
0.59 to 54.24		5.61
0.38 to 90.64		5.50
0.10 to 533		4.24
0.07 to 550		4.16
0.05 to 477		4.15
0.08 to 224		3.73
0.05 to 472		3.32
0.03 to 453		2.75
0.27 to 27.83		2.32
0.02 to 389		2.14
0.21 to 21.15		2.01
0.12 to 31.91		2.01
0.18 to 21.65		1.92
0.04 to 95.19		1.87
0.08 to 51.12		1.82
0.09 to 50.71		1.78
0.22 to 13.40		1.64
0.08 to 41.21		1.60
0.17 to 14.08		1.49
0.11 to 19.76		1.47
0.19 to 10.28		1.45
0.18 to 11.28		1.44
0.16 to 12.44		1.42
0.14 to 13.55		1.41
0.17 to 10.60		1.39
0.16 to 11.02		1.41
0.12 to 15.13		1.41
0.08 to 34.32		1.35
0.13 to 13.20		1.35
0.13 to 13.54		1.31
0.12 to 14.87		1.29
0.13 to 12.35		1.36
0.08 to 34.82		1.29
0.15 to 10.85		1.24
0.13 to 11.12		1.23
0.15 to 9.24		1.19
0.13 to 10.70		1.18
0.07 to 17.60		1.12
0.14 to 8.09		1.04
0.12 to 8.45		1.03
0.11 to 9.14		TASP_SC_40MG_QW0.98
0.12 to 7.48		0.91
0.12 to 6.46		0.88
0.08 to 9.41		0.83
0.08 to 8.09		0.80
0.09 to 6.27		0.74
0.03 to 15.72		0.77
0.07 to 7.38		0.65
0.02 to 27.44		0.66
0.02 to 24.08		0.64
0.08 to 4.65		0.63
0.08 to 4.45		0.60
0.03 to 9.83		0.61
0.04 to 10.31		0.55
0.07 to 4.42		0.46
0.05 to 4.03		0.46
0.06 to 3.56		0.44
0.03 to 5.59		0.38
0.01 to 16.39		0.39
0.01 to 15.49		0.38
0.03 to 5.16		0.37
0.03 to 5.27		0.33
0.02 to 4.25		0.31
0.01 to 14.76		0.26
0.02 to 3.44
EXEN_SC_5UG_BID1.73
0.99 to 2.97		9.73
0.49 to 579		9.41
1.37 to 82.07		6.65
1.02 to 52.95		5.68
1.73 to 19.95		5.59
0.98 to 45.58		5.62
0.19 to 366		4.39
0.13 to 399		4.26
0.09 to 313		4.19
0.15 to 138		3.74
0.08 to 322		3.39
0.05 to 310		2.81
0.79 to 10.16		2.30
0.03 to 300		2.15
0.66 to 8.08		2.09
0.27 to 15.90		2.02
0.53 to 9.09		1.97
0.06 to 59.67		1.88
0.18 to 28.84		1.84
0.18 to 29.53		1.82
0.88 to 4.22		1.69
0.15 to 23.56		1.61
0.63 to 4.38		1.51
0.28 to 8.77		1.50
0.67 to 3.38		1.47
0.73 to 3.21		1.46
0.54 to 4.21		1.45
0.45 to 4.99		1.43
0.66 to 3.24		1.42
0.63 to 3.34		1.43
0.33 to 6.32		1.39
0.18 to 21.27		1.38
0.42 to 4.57		1.38
0.39 to 5.34		1.36
0.36 to 5.68		1.34
0.42 to 4.30		1.37
0.19 to 20.05		1.31
0.48 to 3.88		1.26
0.42 to 3.83		1.25
0.56 to 2.82		1.22
0.42 to 3.57		1.21
0.18 to 8.15		1.15
0.62 to 2.15		1.07
0.45 to 2.69		1.05
0.31 to 3.56		1.02
0.13 to 8.23		EXEN_SC_5UG_BID0.94
0.54 to 1.67		0.90
0.25 to 3.48		0.84
0.23 to 3.13		0.82
0.32 to 1.95		0.78
0.06 to 8.39		0.78
0.22 to 2.86		0.67
0.03 to 15.40		0.66
0.03 to 14.99		0.65
0.32 to 1.34		0.65
0.09 to 4.29		0.62
0.08 to 4.54		0.60
0.10 to 5.15		0.56
0.25 to 1.35		0.47
0.17 to 1.39		0.46
0.21 to 1.09		0.46
0.08 to 2.29		0.40
0.02 to 10.75		0.40
0.02 to 8.84		0.39
0.07 to 2.47		0.38
0.07 to 2.43		0.33
0.05 to 1.99		0.31
0.01 to 10.11		0.27
0.04 to 1.55
EXEN_SC_10UG_BID1.84
1.24 to 2.68		10.62
0.53 to 586		9.93
1.56 to 85.17		7.06
1.12 to 54.47		6.06
2.11 to 19.45		5.98
1.08 to 44.38		5.96
0.20 to 385		4.64
0.13 to 445		4.56
0.10 to 360		4.51
0.17 to 136		3.95
0.09 to 333		3.62
0.05 to 330		3.01
0.93 to 9.97		2.47
0.03 to 328		2.30
0.75 to 7.77		2.20
0.31 to 16.89		2.16
0.61 to 8.63		2.06
0.07 to 62.00		2.02
0.20 to 30.48		1.96
0.20 to 31.15		1.95
1.12 to 3.70		1.78
0.17 to 24.67		1.72
0.67 to 4.62		1.61
0.31 to 9.00		1.59
0.88 to 2.92		1.56
0.90 to 2.89		1.56
0.65 to 4.01		1.54
0.53 to 4.97		1.53
0.82 to 2.97		1.51
0.78 to 3.10		1.51
0.38 to 6.55		1.49
0.21 to 22.11		1.47
0.49 to 4.41		1.47
0.45 to 5.17		1.45
0.42 to 5.45		1.44
0.51 to 3.80		1.44
0.21 to 20.54		1.41
0.56 to 3.65		1.34
0.47 to 3.72		1.34
0.72 to 2.46		1.30
0.48 to 3.36		1.28
0.20 to 8.45		1.22
0.77 to 1.90		1.14
0.54 to 2.42		1.12
0.37 to 3.42		1.10
0.15 to 8.45		1.07
0.60 to 1.86		EXEN_SC_10UG_BID0.97
0.30 to 3.17		0.90
0.27 to 3.08		0.88
0.42 to 1.67		0.84
0.07 to 8.27		0.83
0.25 to 2.81		0.71
0.04 to 15.81		0.71
0.03 to 15.09		0.70
0.41 to 1.19		0.68
0.11 to 4.51		0.66
0.09 to 4.75		0.64
0.11 to 5.22		0.60
0.31 to 1.18		0.50
0.21 to 1.27		0.49
0.26 to 1.00		0.49
0.09 to 2.34		0.43
0.02 to 10.62		0.42
0.02 to 9.33		0.41
0.08 to 2.56		0.41
0.09 to 2.33		0.35
0.05 to 2.08		0.33
0.01 to 10.50		0.29
0.04 to 1.58
EXENROSI_SC_10-4UG_BID1.90
0.55 to 6.45		11.09
0.42 to 731		10.46
1.16 to 110		7.24
0.82 to 73.81		6.27
1.24 to 32.05		6.12
0.75 to 62.17		6.09
0.18 to 457		4.88
0.12 to 475		4.66
0.09 to 426		4.59
0.13 to 186		4.10
0.08 to 431		3.82
0.04 to 363		3.09
0.57 to 16.08		2.63
0.03 to 380		2.39
0.48 to 12.21		2.27
0.23 to 23.10		2.25
0.40 to 13.48		2.14
0.06 to 77.02		2.11
0.15 to 36.76		2.02
0.16 to 41.54		2.02
0.56 to 7.68		1.86
0.13 to 31.69		1.79
0.40 to 8.21		1.66
0.22 to 13.23		1.64
0.44 to 6.23		1.61
0.45 to 6.11		1.61
0.38 to 7.12		1.60
0.32 to 8.03		1.58
0.42 to 5.95		1.55
0.40 to 6.20		1.55
0.26 to 10.10		1.58
0.15 to 29.22		1.51
0.30 to 7.57		1.54
0.29 to 8.17		1.50
0.42 to 5.49		1.48
0.31 to 6.59		1.52
0.16 to 25.05		1.45
0.32 to 6.56		1.41
0.28 to 6.44		1.38
0.36 to 5.15		1.35
0.29 to 5.93		1.32
0.15 to 11.83		1.26
0.35 to 4.38		1.18
0.29 to 4.74		1.15
0.23 to 5.66		1.13
0.11 to 12.25		1.11
0.29 to 4.03		1.04
0.32 to 3.32		EXENROSI_SC_10-4UG_BID0.92
0.17 to 5.31		0.91
0.22 to 3.31		0.86
0.06 to 11.30		0.87
0.16 to 4.68		0.74
0.03 to 19.98		0.72
0.03 to 19.33		0.72
0.20 to 2.63		0.70
0.08 to 6.53		0.68
0.07 to 7.11		0.68
0.08 to 7.04		0.62
0.16 to 2.32		0.51
0.12 to 2.26		0.51
0.13 to 2.00		0.49
0.06 to 3.48		0.44
0.02 to 13.39		0.44
0.02 to 10.65		0.42
0.06 to 3.59		0.41
0.06 to 3.42		0.36
0.04 to 3.18		0.34
0.01 to 13.54		0.30
0.03 to 2.42
LIXI_SC_30UG_QD2.05
0.63 to 6.44		11.91
0.48 to 719		10.98
1.27 to 121		7.85
0.95 to 77.04		6.76
1.43 to 34.60		6.71
0.87 to 63.47		6.63
0.19 to 486		5.27
0.12 to 539		5.04
0.09 to 450		5.06
0.16 to 182		4.42
0.08 to 483		4.14
0.05 to 404		3.35
0.63 to 17.54		2.89
0.03 to 398		2.59
0.53 to 13.18		2.45
0.26 to 23.16		2.41
0.44 to 14.74		2.30
0.07 to 80.59		2.27
0.18 to 41.25		2.15
0.18 to 43.53		2.20
0.61 to 7.92		1.97
0.15 to 33.69		1.92
0.44 to 8.67		1.79
0.25 to 13.65		1.78
0.48 to 6.50		1.75
0.49 to 6.21		1.75
0.40 to 7.58		1.71
0.35 to 8.36		1.70
0.46 to 6.22		1.68
0.45 to 6.43		1.69
0.29 to 10.41		1.66
0.22 to 25.72		1.62
0.32 to 8.16		1.64
0.31 to 8.83		1.64
0.29 to 9.42		1.60
0.32 to 7.30		1.65
0.21 to 24.36		1.57
0.35 to 6.85		1.50
0.33 to 6.50		1.49
0.40 to 5.40		1.46
0.33 to 6.41		1.46
0.16 to 12.39		1.36
0.40 to 4.51		1.29
0.32 to 4.91		1.23
0.24 to 6.29		1.21
0.12 to 12.28		1.19
0.32 to 4.33		1.11
0.33 to 3.70		1.09
0.19 to 5.86		LIXI_SC_30UG_QD0.98
0.22 to 3.79		0.93
0.06 to 12.70		0.92
0.31 to 2.76		0.78
0.03 to 22.61		0.77
0.03 to 21.52		0.78
0.21 to 2.70		0.78
0.08 to 6.80		0.74
0.08 to 6.55		0.73
0.11 to 6.38		0.68
0.17 to 2.56		0.56
0.13 to 2.54		0.55
0.15 to 2.09		0.54
0.07 to 3.62		0.47
0.02 to 13.91		0.48
0.02 to 12.06		0.46
0.08 to 2.79		0.46
0.08 to 2.60		0.39
0.05 to 3.00		0.37
0.01 to 13.70		0.32
0.04 to 2.34
INS_PREMIX2.10
0.98 to 4.75		12.39
0.55 to 761		11.41
1.60 to 107		8.12
1.17 to 68.98		6.94
2.00 to 27.42		6.86
1.10 to 59.33		6.88
0.22 to 476		5.40
0.15 to 523		5.38
0.11 to 420		5.17
0.18 to 168		4.60
0.10 to 421		4.18
0.06 to 401		3.42
0.90 to 14.20		2.83
0.03 to 383		2.63
0.75 to 11.30		2.55
0.31 to 21.79		2.51
0.60 to 12.47		2.34
0.08 to 79.60		2.34
0.21 to 37.76		2.25
0.21 to 40.22		2.22
0.97 to 6.01		2.02
0.19 to 31.34		1.98
0.65 to 6.61		1.85
0.32 to 11.84		1.82
0.76 to 4.71		1.79
0.77 to 4.80		1.78
0.60 to 5.82		1.76
0.50 to 7.02		1.75
0.71 to 4.76		1.73
0.70 to 4.92		1.74
0.39 to 8.90		1.75
0.21 to 27.54		1.69
0.47 to 6.74		1.69
0.44 to 7.39		1.66
0.40 to 7.55		1.64
0.76 to 3.50		1.66
0.22 to 24.90		1.62
0.51 to 5.43		1.54
0.45 to 5.29		1.52
0.61 to 4.05		1.48
0.46 to 4.92		1.47
0.20 to 11.19		1.40
0.65 to 3.27		1.30
0.49 to 3.78		1.27
0.37 to 5.00		1.25
0.16 to 11.26		1.22
0.51 to 3.10		1.14
0.60 to 2.38		1.10
0.30 to 4.45		1.03
0.26 to 4.52		INS_PREMIX0.96
0.07 to 11.09		0.97
0.24 to 3.81		0.82
0.04 to 19.91		0.81
0.03 to 18.83		0.79
0.35 to 2.03		0.79
0.11 to 5.88		0.76
0.10 to 6.47		0.73
0.12 to 6.90		0.69
0.28 to 1.87		0.57
0.18 to 1.95		0.56
0.23 to 1.62		0.56
0.09 to 3.11		0.49
0.02 to 13.18		0.49
0.02 to 11.03		0.47
0.09 to 3.28		0.47
0.08 to 3.06		0.40
0.05 to 2.75		0.39
0.01 to 12.29		0.33
0.05 to 2.14
EMPAGLIFLOZIN2.20
0.23 to 26.89		13.61
0.28 to 1366		12.43
0.62 to 309		8.65
0.45 to 212		7.36
0.61 to 107		7.23
0.42 to 170		7.45
0.11 to 1027		5.93
0.08 to 1001		5.58
0.07 to 746		5.49
0.10 to 391		5.01
0.06 to 779		4.54
0.04 to 702		3.60
0.30 to 58.97		3.03
0.02 to 690		2.80
0.22 to 41.98		2.70
0.13 to 61.81		2.68
0.20 to 43.04		2.47
0.04 to 165		2.52
0.09 to 100		2.45
0.10 to 91.24		2.37
0.23 to 29.81		2.15
0.08 to 87.74		2.10
0.17 to 30.65		1.95
0.12 to 38.00		1.94
0.18 to 24.60		1.89
0.20 to 22.18		1.88
0.16 to 24.62		1.85
0.16 to 27.46		1.83
0.18 to 22.20		1.81
0.17 to 23.20		1.86
0.13 to 31.07		1.93
0.08 to 69.32		1.75
0.14 to 25.79		1.78
0.13 to 27.86		1.76
0.13 to 28.48		1.71
0.13 to 24.99		1.85
0.09 to 63.47		1.67
0.15 to 25.26		1.63
0.13 to 23.04		1.63
0.16 to 20.98		1.54
0.13 to 22.29		1.57
0.08 to 32.71		1.46
0.15 to 18.18		1.37
0.13 to 18.98		1.32
0.11 to 19.68		1.36
0.06 to 29.67		1.28
0.12 to 16.12		1.19
0.12 to 15.05		1.17
0.09 to 17.89		1.08
0.08 to 17.34		1.04
0.09 to 13.84		EMPAGLIFLOZIN1.02
0.07 to 16.03		0.87
0.02 to 44.57		0.86
0.02 to 40.22		0.84
0.08 to 10.16		0.82
0.04 to 18.57		0.80
0.04 to 19.38		0.82
0.04 to 19.94		0.72
0.07 to 9.96		0.60
0.05 to 8.53		0.60
0.06 to 7.34		0.58
0.03 to 10.70		0.51
0.01 to 29.57		0.52
0.01 to 26.51		0.50
0.03 to 10.40		0.50
0.03 to 10.21		0.42
0.02 to 8.83		0.41
0.01 to 27.70		0.34
0.02 to 6.97
LIXI_SC_30UG_BID2.20
0.70 to 7.07		12.92
0.52 to 823		12.07
1.36 to 125		8.40
1.01 to 81.45		7.18
1.51 to 35.80		7.08
0.95 to 71.56		7.00
0.20 to 549		5.76
0.13 to 595		5.51
0.10 to 466		5.35
0.17 to 190		4.73
0.09 to 480		4.51
0.05 to 452		3.60
0.68 to 18.46		3.05
0.03 to 397		2.78
0.58 to 13.89		2.63
0.29 to 26.03		2.61
0.50 to 15.38		2.44
0.07 to 88.32		2.46
0.19 to 44.18		2.37
0.19 to 44.96		2.35
0.67 to 8.52		2.13
0.17 to 36.10		2.05
0.48 to 9.19		1.95
0.26 to 14.29		1.91
0.53 to 6.95		1.89
0.55 to 6.57		1.87
0.44 to 8.20		1.87
0.37 to 9.64		1.81
0.50 to 6.64		1.81
0.50 to 6.97		1.81
0.32 to 10.99		1.80
0.22 to 27.97		1.76
0.35 to 8.64		1.77
0.34 to 9.22		1.76
0.31 to 10.11		1.72
0.35 to 7.91		1.76
0.21 to 27.40		1.71
0.40 to 7.17		1.61
0.35 to 7.14		1.61
0.43 to 5.79		1.55
0.35 to 6.52		1.54
0.17 to 14.11		1.46
0.45 to 4.83		1.38
0.35 to 5.48		1.33
0.27 to 6.64		1.30
0.14 to 13.78		1.28
0.35 to 4.62		1.20
0.36 to 4.01		1.15
0.21 to 6.38		1.08
0.36 to 3.28		1.03
0.26 to 4.09		0.98
0.06 to 13.72		LIXI_SC_30UG_BID0.84
0.04 to 22.83		0.83
0.03 to 23.76		0.83
0.23 to 2.92		0.82
0.09 to 7.06		0.80
0.08 to 7.21		0.78
0.12 to 7.02		0.73
0.19 to 2.71		0.60
0.14 to 2.68		0.59
0.16 to 2.28		0.57
0.08 to 3.90		0.51
0.02 to 14.39		0.51
0.02 to 13.07		0.49
0.09 to 3.00		0.49
0.09 to 2.77		0.42
0.05 to 3.36		0.40
0.01 to 15.43		0.34
0.04 to 2.57
EFPE_SC_6MG_QW2.58
0.11 to 47.21		16.02
0.22 to 1920		14.30
0.39 to 488		10.34
0.26 to 328		8.39
0.32 to 199		8.82
0.24 to 274		8.21
0.14 to 1104		6.70
0.06 to 1392		6.49
0.05 to 1157		6.45
0.07 to 566		5.95
0.04 to 1113		5.23
0.03 to 1140		4.31
0.15 to 105		3.57
0.01 to 1112		3.24
0.12 to 73.59		3.10
0.09 to 107		3.07
0.11 to 79.56		2.85
0.03 to 275		2.86
0.06 to 148		2.82
0.06 to 168		2.74
0.12 to 53.96		2.55
0.05 to 123		2.48
0.09 to 56.12		2.27
0.07 to 71.43		2.24
0.09 to 45.42		2.24
0.10 to 44.45		2.23
0.09 to 47.20		2.19
0.08 to 47.88		2.16
0.09 to 42.03		2.13
0.09 to 43.39		2.16
0.07 to 55.86		2.17
0.06 to 116		2.07
0.07 to 46.34		2.07
0.08 to 48.73		2.08
0.07 to 52.29		2.01
0.07 to 46.13		2.15
0.05 to 106		2.01
0.08 to 44.26		1.90
0.08 to 41.91		1.89
0.08 to 36.23		1.81
0.07 to 41.21		1.81
0.05 to 55.84		1.73
0.08 to 32.93		1.58
0.07 to 34.32		1.58
0.06 to 35.12		1.54
0.04 to 56.06		1.50
0.06 to 30.90		1.41
0.06 to 27.02		1.36
0.05 to 31.64		1.29
0.04 to 30.48		1.22
0.05 to 26.41		1.15
0.02 to 47.02		1.19
0.04 to 26.67		EFPE_SC_6MG_QW0.98
0.03 to 29.29		0.99
0.04 to 18.87		0.95
0.03 to 30.64		0.92
0.02 to 33.38		0.93
0.03 to 32.25		0.86
0.03 to 18.24		0.70
0.03 to 15.30		0.70
0.03 to 14.08		0.66
0.02 to 19.23		0.60
0.01 to 44.57		0.60
0.01 to 40.88		0.58
0.02 to 17.25		0.57
0.02 to 16.66		0.48
0.01 to 16.43		0.46
0.00 to 40.59		0.39
0.01 to 12.48
EFPE_SC_4MG_QW2.62
0.13 to 55.59		15.72
0.23 to 2078		14.52
0.40 to 533		10.31
0.30 to 348		8.63
0.36 to 223		8.87
0.27 to 303		8.10
0.15 to 1182		6.79
0.06 to 1433		6.61
0.05 to 1268		6.47
0.07 to 567		5.77
0.05 to 1135		5.31
0.03 to 1129		4.30
0.16 to 112		3.72
0.02 to 984		3.30
0.13 to 83.73		3.14
0.09 to 118		3.08
0.12 to 83.67		2.94
0.03 to 273		3.00
0.06 to 150		2.88
0.06 to 182		2.80
0.12 to 63.56		2.63
0.05 to 130		2.48
0.10 to 58.62		2.32
0.08 to 75.44		2.28
0.10 to 50.52		2.26
0.10 to 49.70		2.23
0.10 to 52.89		2.17
0.09 to 55.82		2.20
0.10 to 48.12		2.15
0.10 to 48.65		2.16
0.07 to 60.75		2.23
0.05 to 110		2.10
0.08 to 53.63		2.10
0.08 to 54.12		2.03
0.08 to 61.35		2.00
0.08 to 53.41		2.24
0.05 to 105		2.00
0.08 to 48.60		1.91
0.08 to 45.44		1.91
0.08 to 42.06		1.85
0.07 to 45.78		1.87
0.05 to 63.27		1.76
0.08 to 36.21		1.60
0.08 to 37.23		1.61
0.06 to 41.73		1.51
0.04 to 61.72		1.52
0.07 to 34.87		1.41
0.07 to 31.13		1.39
0.05 to 38.25		1.30
0.05 to 32.72		1.23
0.05 to 29.70		1.16
0.02 to 49.33		1.20
0.04 to 31.76		1.02
0.03 to 29.77		EFPE_SC_4MG_QW1.00
0.04 to 21.73		0.97
0.03 to 34.13		0.95
0.02 to 36.40		0.98
0.03 to 36.46		0.85
0.04 to 19.34		0.71
0.03 to 17.76		0.71
0.03 to 15.93		0.68
0.02 to 20.77		0.61
0.01 to 47.61		0.60
0.01 to 45.79		0.58
0.02 to 18.54		0.59
0.02 to 18.27		0.49
0.01 to 16.76		0.46
0.00 to 39.57		0.39
0.01 to 13.99
INS_GLARGINE2.63
1.55 to 4.41		15.15
0.76 to 915		14.15
2.21 to 123		10.06
1.64 to 76.89		8.71
3.04 to 27.47		8.51
1.52 to 66.96		8.56
0.29 to 577		6.62
0.20 to 644		6.61
0.14 to 481		6.48
0.24 to 208		5.77
0.12 to 525		5.32
0.08 to 490		4.31
1.38 to 13.46		3.56
0.04 to 463		3.32
1.08 to 10.94		3.17
0.42 to 24.63		3.10
0.88 to 12.24		2.95
0.10 to 89.82		2.91
0.28 to 44.82		2.81
0.28 to 44.85		2.78
1.67 to 5.12		2.56
0.24 to 35.48		2.48
0.86 to 7.25		2.29
0.46 to 12.66		2.29
1.11 to 4.79		2.25
1.38 to 3.90		2.24
0.92 to 5.69		2.23
0.77 to 6.50		2.20
1.29 to 3.74		2.17
1.18 to 4.11		2.16
0.60 to 8.61		2.14
0.29 to 31.63		2.11
0.73 to 6.04		2.11
0.64 to 7.34		2.11
0.54 to 8.61		2.07
0.62 to 6.11		2.07
0.29 to 30.00		2.02
0.74 to 5.62		1.94
0.64 to 5.62		1.92
0.94 to 3.88		1.86
0.65 to 5.13		1.85
0.29 to 11.90		1.77
0.94 to 3.13		1.65
0.69 to 3.90		1.60
0.58 to 4.38		1.56
0.22 to 12.32		1.53
0.75 to 3.09		1.44
0.84 to 2.44		1.39
0.38 to 5.01		1.29
0.37 to 4.72		1.26
0.49 to 2.85		1.19
0.10 to 12.05		1.20
0.34 to 4.28		1.01
0.05 to 23.53		1.00
0.05 to 22.38		INS_GLARGINE0.98
0.15 to 6.57		0.95
0.13 to 7.20		0.93
0.16 to 7.72		0.86
0.39 to 1.94		0.72
0.27 to 2.01		0.71
0.40 to 1.29		0.70
0.12 to 3.33		0.62
0.03 to 15.29		0.61
0.03 to 13.46		0.58
0.11 to 3.77		0.58
0.12 to 3.48		0.50
0.07 to 3.09		0.48
0.01 to 15.73		0.41
0.06 to 2.30
TASP_SC_30MG_QW2.67
0.42 to 17.07		15.70
0.50 to 1248		15.05
1.08 to 248		10.49
0.75 to 161		8.83
1.10 to 79.53		8.87
0.75 to 130		8.86
0.17 to 854		6.98
0.13 to 786		6.83
0.09 to 660		6.64
0.16 to 300		5.98
0.09 to 642		5.43
0.06 to 707		4.37
0.52 to 37.44		3.72
0.03 to 624		3.42
0.40 to 29.18		3.23
0.23 to 50.61		3.23
0.35 to 30.44		3.06
0.06 to 137		3.02
0.15 to 73.07		2.95
0.17 to 79.21		2.84
0.43 to 19.62		2.63
0.14 to 64.39		2.52
0.34 to 19.99		2.37
0.19 to 27.73		2.31
0.37 to 14.35		2.31
0.34 to 15.50		2.30
0.30 to 17.21		2.27
0.28 to 18.92		2.25
0.33 to 15.07		2.20
0.33 to 15.44		2.25
0.23 to 20.96		2.27
0.15 to 51.39		2.12
0.25 to 17.92		2.17
0.25 to 19.26		2.19
0.22 to 21.35		2.06
0.25 to 16.46		2.20
0.15 to 55.23		2.07
0.27 to 15.68		1.99
0.24 to 15.87		1.96
0.29 to 12.27		1.91
0.25 to 14.64		1.88
0.14 to 25.54		1.78
0.28 to 11.72		1.68
0.23 to 12.21		1.64
0.20 to 13.21		1.59
0.22 to 13.24		1.54
0.23 to 10.63		1.46
0.22 to 9.15		1.44
0.15 to 12.42		1.29
0.15 to 12.77		1.27
0.17 to 9.30		1.22
0.05 to 22.36		1.22
0.14 to 11.10		1.05
0.03 to 39.19		1.03
0.03 to 36.50		1.02
0.15 to 6.68		TASP_SC_30MG_QW0.96
0.06 to 14.58		0.97
0.08 to 15.35		0.89
0.12 to 6.36		0.74
0.09 to 5.89		0.73
0.11 to 5.05		0.71
0.06 to 7.56		0.63
0.02 to 23.28		0.60
0.02 to 22.54		0.60
0.06 to 7.66		0.59
0.05 to 7.27		0.51
0.04 to 6.13		0.48
0.01 to 23.02		0.41
0.03 to 4.96
DANU_PO_120MG_BID2.77
0.40 to 19.34		16.53
0.44 to 1408		15.08
0.99 to 268		10.74
0.70 to 185		9.09
1.01 to 84.13		9.02
0.67 to 142		9.25
0.18 to 852		7.10
0.12 to 912		7.00
0.10 to 753		6.73
0.16 to 352		6.34
0.08 to 839		5.49
0.06 to 749		4.55
0.47 to 41.70		3.74
0.03 to 662		3.51
0.38 to 34.58		3.36
0.22 to 52.12		3.29
0.34 to 36.11		3.15
0.07 to 164		2.96
0.30 to 50.96		2.92
0.29 to 51.65		2.99
0.40 to 22.48		2.71
0.13 to 67.97		2.62
0.30 to 23.02		2.46
0.19 to 31.78		2.44
0.31 to 18.10		2.39
0.32 to 17.48		2.40
0.28 to 20.98		2.34
0.25 to 21.17		2.32
0.30 to 17.40		2.28
0.29 to 17.73		2.32
0.21 to 24.68		2.34
0.15 to 58.11		2.20
0.24 to 20.39		2.25
0.23 to 22.20		2.19
0.21 to 23.33		2.15
0.23 to 19.10		2.27
0.14 to 58.16		2.11
0.25 to 18.56		2.05
0.24 to 17.53		2.00
0.26 to 15.32		1.93
0.23 to 16.49		1.93
0.13 to 27.71		1.84
0.26 to 13.45		1.74
0.22 to 14.25		1.69
0.18 to 15.59		1.67
0.10 to 28.72		1.60
0.22 to 12.42		1.51
0.21 to 11.29		1.47
0.14 to 14.50		1.35
0.15 to 13.06		1.31
0.15 to 10.18		1.25
0.05 to 24.87		1.25
0.14 to 12.01		1.08
0.03 to 40.65		1.06
0.03 to 41.94		1.05
0.14 to 7.95		1.04
0.07 to 15.70		DANU_PO_120MG_BID0.97
0.07 to 16.47		0.92
0.11 to 7.35		0.76
0.09 to 6.70		0.75
0.09 to 5.91		0.74
0.05 to 8.67		0.66
0.02 to 27.14		0.66
0.02 to 23.18		0.63
0.05 to 7.99		0.62
0.05 to 7.91		0.55
0.09 to 2.66		0.51
0.01 to 25.52		0.43
0.08 to 1.97
LIXI_SC_10UG_QD2.87
0.37 to 15.26		16.25
0.46 to 1258		15.43
0.93 to 218		10.73
0.67 to 152		9.29
0.94 to 72.15		9.19
0.65 to 123		9.00
0.21 to 828		7.16
0.12 to 868		7.00
0.08 to 735		6.68
0.16 to 313		6.09
0.09 to 757		5.61
0.05 to 749		4.62
0.44 to 36.00		3.86
0.03 to 620		3.56
0.34 to 28.72		3.29
0.21 to 47.79		3.28
0.31 to 31.21		3.07
0.06 to 145		3.06
0.15 to 73.32		3.00
0.15 to 76.89		3.03
0.36 to 18.61		2.76
0.13 to 65.02		2.66
0.28 to 19.12		2.49
0.18 to 26.54		2.47
0.28 to 15.25		2.44
0.29 to 14.80		2.44
0.26 to 17.81		2.38
0.22 to 18.24		2.35
0.27 to 14.31		2.33
0.27 to 14.50		2.31
0.20 to 22.69		2.30
0.18 to 41.38		2.25
0.22 to 16.98		2.26
0.21 to 18.43		2.22
0.19 to 19.44		2.22
0.21 to 16.31		2.33
0.18 to 36.79		2.19
0.22 to 15.07		2.10
0.21 to 14.99		2.08
0.24 to 12.57		1.99
0.21 to 13.08		1.94
0.12 to 24.86		1.91
0.24 to 10.75		1.78
0.19 to 11.62		1.73
0.16 to 13.76		1.64
0.10 to 24.28		1.66
0.19 to 9.75		1.55
0.19 to 8.94		1.48
0.14 to 12.05		1.37
0.16 to 8.99		1.37
0.15 to 8.69		1.22
0.05 to 22.53		1.29
0.14 to 8.10		1.08
0.03 to 36.81		1.02
0.03 to 38.47		1.07
0.13 to 6.41		1.03
0.07 to 13.13		1.03
0.06 to 13.86		LIXI_SC_10UG_QD0.94
0.10 to 5.92		0.78
0.08 to 5.45		0.77
0.09 to 4.83		0.72
0.05 to 7.50		0.65
0.02 to 24.27		0.62
0.02 to 23.22		0.64
0.07 to 4.84		0.64
0.07 to 4.89		0.53
0.04 to 5.88		0.50
0.01 to 24.64		0.44
0.03 to 4.60
INS_LISPRO3.06
1.49 to 6.20		17.07
0.85 to 1010		16.36
2.43 to 147		11.77
1.69 to 93.23		10.00
2.95 to 36.28		9.94
1.66 to 79.40		9.78
0.32 to 678		7.72
0.22 to 808		7.58
0.16 to 573		7.39
0.27 to 244		6.56
0.14 to 596		6.00
0.09 to 566		5.00
1.33 to 18.90		4.12
0.04 to 561		3.84
1.08 to 14.18		3.57
0.48 to 31.21		3.61
0.85 to 16.39		3.43
0.11 to 109		3.36
0.30 to 53.70		3.27
0.31 to 55.34		3.24
1.46 to 7.75		2.94
0.27 to 44.31		2.86
0.93 to 9.46		2.63
0.48 to 16.14		2.63
1.09 to 6.54		2.60
1.17 to 6.11		2.58
0.96 to 7.50		2.56
0.72 to 9.30		2.54
1.06 to 5.94		2.52
1.04 to 6.33		2.50
0.56 to 12.00		2.52
0.31 to 36.51		2.44
0.69 to 8.67		2.45
0.65 to 9.73		2.38
0.61 to 10.33		2.38
0.70 to 7.34		2.38
0.31 to 36.22		2.34
0.88 to 6.19		2.24
0.65 to 7.33		2.22
0.91 to 5.32		2.17
0.66 to 6.81		2.15
0.30 to 14.91		2.02
0.93 to 4.32		1.89
0.99 to 3.66		1.84
0.53 to 6.62		1.80
0.23 to 14.62		1.77
0.74 to 4.05		1.66
0.85 to 3.26		1.60
0.43 to 6.12		1.47
0.39 to 5.95		1.46
0.54 to 3.56		1.39
0.10 to 14.71		1.37
0.37 to 5.15		1.16
0.05 to 28.69		1.18
0.05 to 26.74		1.16
0.51 to 2.57		1.13
0.16 to 8.13		1.09
0.14 to 8.88		1.07
0.17 to 9.83		INS_LISPRO0.83
0.34 to 2.10		0.82
0.33 to 2.04		0.80
0.12 to 4.46		0.70
0.03 to 18.35		0.70
0.03 to 16.25		0.68
0.12 to 4.65		0.67
0.12 to 4.15		0.58
0.08 to 3.79		0.54
0.01 to 17.57		0.47
0.07 to 2.95
STANDARD_CARE3.69
1.40 to 9.15		20.89
0.91 to 1315		19.91
2.59 to 191		14.19
1.85 to 129		12.12
3.09 to 50.07		12.02
1.70 to 101		11.79
0.36 to 852		9.37
0.24 to 929		9.05
0.19 to 739		8.87
0.31 to 313		8.10
0.17 to 724		7.34
0.10 to 705		6.05
1.41 to 24.74		4.84
0.05 to 705		4.67
1.12 to 19.61		4.34
0.53 to 39.27		4.37
0.94 to 21.47		4.14
0.13 to 142		4.04
0.34 to 67.16		3.92
0.33 to 70.63		3.92
1.42 to 10.81		3.53
0.30 to 57.58		3.47
0.90 to 13.19		3.19
0.48 to 20.20		3.23
1.07 to 9.03		3.17
1.14 to 8.62		3.11
0.92 to 10.49		3.09
0.76 to 12.45		3.05
1.05 to 8.52		3.04
1.04 to 8.68		3.03
0.59 to 16.48		2.99
0.33 to 50.92		2.94
0.72 to 11.61		2.95
0.69 to 12.86		2.90
0.63 to 13.86		2.89
0.71 to 10.69		2.94
0.35 to 46.67		2.84
0.80 to 9.48		2.71
0.66 to 10.15		2.68
0.90 to 7.70		2.59
0.68 to 9.24		2.59
0.34 to 19.29		2.45
0.89 to 6.36		2.29
0.79 to 6.52		2.25
0.53 to 8.99		2.16
0.25 to 19.66		2.14
0.72 to 5.98		2.01
0.79 to 4.87		1.95
0.44 to 8.53		1.79
0.39 to 7.96		1.76
0.51 to 5.41		1.67
0.12 to 19.57		1.67
0.37 to 7.26		1.42
0.07 to 35.64		1.41
0.06 to 33.70		1.40
0.50 to 3.77		1.35
0.17 to 10.62		1.32
0.15 to 11.15		1.29
0.18 to 12.00		1.21
0.48 to 2.98		STANDARD_CARE0.99
0.34 to 2.88		0.96
0.14 to 5.83		0.85
0.04 to 23.51		0.85
0.04 to 21.14		0.81
0.13 to 6.09		0.80
0.13 to 5.39		0.69
0.08 to 5.15		0.65
0.02 to 21.61		0.57
0.07 to 3.84
GLIMEPIRIDE3.73
1.89 to 6.86		21.33
1.02 to 1269		19.98
3.05 to 174		14.12
2.19 to 111		12.19
4.14 to 39.36		11.90
2.14 to 98.43		12.03
0.41 to 786		9.48
0.26 to 914		9.15
0.19 to 683		9.00
0.33 to 296		7.95
0.17 to 699		7.42
0.10 to 711		6.09
1.82 to 19.78		4.99
0.06 to 662		4.67
1.45 to 15.86		4.41
0.56 to 35.03		4.40
1.17 to 18.06		4.17
0.13 to 128		4.12
0.37 to 64.34		3.92
0.38 to 64.89		3.91
2.18 to 7.63		3.57
0.32 to 50.20		3.47
1.14 to 10.86		3.24
0.65 to 18.05		3.22
1.42 to 7.33		3.16
1.70 to 5.97		3.13
1.20 to 8.51		3.11
1.00 to 9.58		3.08
1.59 to 5.80		3.05
1.53 to 6.04		3.02
0.77 to 13.54		3.00
0.39 to 48.34		2.97
0.92 to 8.92		3.00
0.87 to 10.43		2.94
0.72 to 12.25		2.92
0.80 to 9.27		2.91
0.38 to 43.46		2.85
0.97 to 8.45		2.73
0.82 to 8.29		2.70
1.16 to 5.95		2.60
0.83 to 7.84		2.59
0.39 to 16.97		2.48
1.18 to 4.79		2.30
0.92 to 5.97		2.24
0.72 to 7.15		2.19
0.28 to 18.01		2.17
0.91 to 4.76		2.03
1.00 to 3.92		1.96
0.50 to 7.55		1.82
0.48 to 6.75		1.78
0.62 to 4.43		1.66
0.14 to 17.58		1.68
0.44 to 6.38		1.43
0.07 to 32.32		1.40
0.06 to 32.60		1.41
0.77 to 2.52		1.37
0.20 to 9.48		1.34
0.17 to 10.53		1.30
0.21 to 11.24		1.22
0.49 to 3.03		1.01
0.35 to 2.90		GLIMEPIRIDE0.97
0.16 to 4.99		0.86
0.04 to 22.48		0.85
0.04 to 20.06		0.82
0.15 to 5.60		0.82
0.15 to 4.77		0.70
0.10 to 4.42		0.65
0.02 to 22.79		0.58
0.08 to 3.39
HRS7535_PO_30MG_QD3.77
0.85 to 20.93		22.36
0.81 to 1638		21.00
1.99 to 286		14.79
1.38 to 195		12.54
1.92 to 95.92		12.64
1.30 to 166		12.44
0.31 to 1078		10.03
0.19 to 1078		9.86
0.17 to 946		9.39
0.26 to 432		8.42
0.15 to 988		7.70
0.08 to 1010		6.36
0.89 to 51.13		5.25
0.04 to 954		4.84
0.75 to 37.52		4.47
0.92 to 29.37		4.52
0.60 to 41.67		4.31
0.11 to 190		4.31
0.26 to 105		4.17
0.27 to 94.29		4.06
0.82 to 24.66		3.81
0.24 to 85.08		3.58
0.61 to 26.35		3.37
0.38 to 39.09		3.29
0.64 to 20.41		3.25
0.67 to 19.57		3.23
0.56 to 22.17		3.24
0.46 to 25.47		3.12
0.63 to 19.98		3.13
0.60 to 19.58		3.13
0.42 to 29.97		3.23
0.26 to 67.36		3.01
0.46 to 25.00		3.07
0.44 to 24.19		3.09
0.41 to 26.33		2.97
0.44 to 21.62		3.15
0.24 to 67.82		2.91
0.51 to 20.08		2.80
0.46 to 18.79		2.76
0.51 to 16.82		2.66
0.46 to 18.22		2.67
0.24 to 33.48		2.54
0.52 to 14.51		2.36
0.44 to 15.31		2.33
0.37 to 18.11		2.29
0.18 to 32.71		2.19
0.44 to 13.16		2.05
0.43 to 11.71		2.03
0.29 to 16.40		1.87
0.28 to 14.32		1.79
0.32 to 11.44		1.74
0.09 to 30.42		1.75
0.26 to 12.91		1.51
0.05 to 48.22		1.48
0.05 to 49.67		1.43
0.30 to 8.62		1.42
0.13 to 16.90		1.36
0.12 to 19.23		1.38
0.13 to 18.37		1.24
0.22 to 8.16		1.04
0.17 to 7.34		1.03
0.20 to 6.43		HRS7535_PO_30MG_QD0.89
0.03 to 34.11		0.88
0.03 to 26.80		0.87
0.09 to 9.24		0.85
0.09 to 9.61		0.73
0.07 to 8.43		0.68
0.02 to 29.13		0.59
0.06 to 6.46
MAZD_SC_6MG_QW4.27
0.17 to 83.25		26.34
0.34 to 3892		24.45
0.58 to 919		16.89
0.42 to 559		14.19
0.50 to 353		14.26
0.37 to 446		14.22
0.13 to 2494		10.51
0.14 to 1998		10.93
0.07 to 2082		10.84
0.11 to 1008		9.80
0.07 to 2062		8.79
0.05 to 1843		7.22
0.24 to 165		5.88
0.02 to 1813		5.66
0.19 to 126		5.20
0.12 to 181		5.21
0.17 to 126		4.83
0.05 to 462		4.80
0.09 to 277		4.71
0.09 to 271		4.58
0.18 to 96.84		4.23
0.08 to 209		4.08
0.14 to 88.16		3.91
0.11 to 112		3.78
0.14 to 77.23		3.71
0.15 to 75.22		3.74
0.13 to 80.16		3.71
0.12 to 83.12		3.61
0.14 to 74.69		3.60
0.14 to 73.85		3.54
0.12 to 101		3.58
0.09 to 183		3.46
0.12 to 75.88		3.56
0.12 to 86.60		3.41
0.11 to 87.50		3.37
0.12 to 72.97		3.57
0.08 to 172		3.32
0.12 to 71.95		3.17
0.11 to 72.81		3.13
0.12 to 64.07		3.06
0.10 to 65.19		3.10
0.07 to 105		2.86
0.12 to 56.35		2.70
0.10 to 55.20		2.63
0.09 to 56.66		2.60
0.06 to 86.80		2.51
0.09 to 49.07		2.34
0.09 to 46.68		2.29
0.07 to 55.54		2.13
0.07 to 50.98		2.05
0.08 to 41.40		1.96
0.03 to 82.28		1.95
0.07 to 49.15		1.66
0.02 to 111		1.63
0.02 to 107		1.62
0.07 to 32.31		1.58
0.04 to 51.20		1.53
0.04 to 57.15		1.54
0.04 to 53.94		1.43
0.05 to 29.37		1.17
0.04 to 26.61		1.16
0.04 to 24.60		1.12
0.03 to 31.29		MAZD_SC_6MG_QW1.01
0.03 to 31.33		0.95
0.03 to 27.52		0.94
0.03 to 28.17		0.82
0.02 to 26.54		0.77
0.01 to 76.05		0.66
0.02 to 21.78
MAZD_SC_3MG_QW4.32
0.20 to 82.18		25.81
0.35 to 3615		24.47
0.63 to 838		16.48
0.46 to 603		14.37
0.58 to 344		14.25
0.42 to 495		14.26
0.14 to 2313		11.05
0.15 to 2248		10.56
0.08 to 1996		10.36
0.13 to 962		9.53
0.07 to 1882		8.90
0.05 to 1941		7.07
0.28 to 161		5.99
0.03 to 1681		5.52
0.22 to 124		5.21
0.14 to 178		5.30
0.19 to 123		4.98
0.05 to 450		4.83
0.11 to 262		4.79
0.11 to 256		4.68
0.20 to 94.73		4.15
0.10 to 214		4.06
0.17 to 89.76		3.92
0.12 to 107		3.78
0.16 to 78.88		3.70
0.17 to 74.06		3.66
0.15 to 83.51		3.63
0.14 to 83.69		3.55
0.16 to 72.70		3.61
0.16 to 74.18		3.55
0.12 to 90.18		3.79
0.09 to 174		3.41
0.13 to 78.15		3.58
0.13 to 81.64		3.52
0.13 to 87.19		3.37
0.13 to 79.79		3.68
0.09 to 171		3.32
0.14 to 73.46		3.16
0.14 to 74.56		3.17
0.14 to 64.76		3.12
0.13 to 67.03		3.07
0.08 to 97.82		2.90
0.13 to 57.56		2.69
0.12 to 56.65		2.62
0.10 to 60.14		2.58
0.06 to 85.11		2.48
0.11 to 51.18		2.36
0.11 to 46.25		2.27
0.09 to 54.57		2.10
0.08 to 50.19		2.03
0.09 to 42.14		1.91
0.04 to 86.17		1.97
0.08 to 45.42		1.67
0.02 to 114		1.66
0.02 to 112		1.64
0.07 to 32.10		1.65
0.04 to 48.03		1.52
0.04 to 54.52		1.60
0.04 to 53.29		1.44
0.06 to 29.04		1.17
0.05 to 28.05		1.18
0.05 to 24.03		1.14
0.04 to 32.51		0.99
0.03 to 34.88		MAZD_SC_3MG_QW0.96
0.03 to 29.46		0.95
0.03 to 30.00		0.80
0.02 to 26.70		0.75
0.01 to 66.38		0.65
0.02 to 22.15
LIXI_SC_20UG_BID4.50
0.76 to 20.65		25.73
0.81 to 1998		24.29
1.98 to 339		17.21
1.36 to 222		14.69
1.96 to 104		14.51
1.19 to 180		14.30
0.31 to 1252		11.53
0.20 to 1271		11.30
0.17 to 987		10.48
0.30 to 465		9.92
0.17 to 1002		9.25
0.09 to 1048		7.38
0.90 to 54.45		6.21
0.05 to 977		5.70
0.70 to 40.73		5.34
0.40 to 67.07		5.18
0.62 to 43.28		5.00
0.12 to 213		4.98
0.27 to 108		4.70
0.29 to 116		4.89
0.75 to 25.45		4.27
0.24 to 97.11		4.27
0.57 to 26.12		3.95
0.35 to 39.41		3.91
0.59 to 20.34		3.86
0.60 to 19.80		3.81
0.54 to 24.02		3.75
0.48 to 25.79		3.72
0.55 to 20.27		3.74
0.56 to 20.71		3.68
0.42 to 31.38		3.59
0.37 to 62.26		3.58
0.45 to 24.75		3.59
0.45 to 26.59		3.57
0.41 to 26.39		3.47
0.43 to 22.50		3.60
0.37 to 59.17		3.47
0.46 to 20.76		3.29
0.44 to 20.53		3.23
0.51 to 17.13		3.18
0.43 to 19.18		3.08
0.23 to 37.40		3.00
0.51 to 14.16		2.81
0.39 to 16.16		2.74
0.35 to 18.80		2.66
0.19 to 35.22		2.59
0.40 to 13.72		2.45
0.39 to 11.92		2.38
0.28 to 18.13		2.18
0.36 to 12.56		2.11
0.31 to 11.68		2.02
0.10 to 32.91		2.02
0.33 to 11.17		1.72
0.06 to 54.90		1.72
0.05 to 54.49		1.71
0.27 to 8.78		1.67
0.13 to 18.11		1.59
0.13 to 18.23		1.57
0.21 to 14.14		1.47
0.22 to 8.01		1.23
0.16 to 7.56		1.22
0.18 to 6.71		1.15
0.11 to 10.72		1.05
0.04 to 37.43		1.04
0.03 to 30.80		LIXI_SC_20UG_BID0.99
0.15 to 6.46		0.84
0.07 to 9.20		0.81
0.01 to 36.24		0.69
0.05 to 7.08
LIXI_SC_5UG_BID4.54
0.82 to 21.32		26.06
0.82 to 1858		24.79
1.98 to 328		17.33
1.34 to 208		14.87
2.10 to 103		14.78
1.35 to 181		14.69
0.34 to 1204		11.23
0.22 to 1284		11.45
0.17 to 1086		10.63
0.28 to 487		9.69
0.17 to 1063		8.83
0.09 to 1173		7.45
0.96 to 50.00		6.31
0.05 to 990		5.70
0.75 to 40.96		5.44
0.40 to 65.87		5.33
0.64 to 44.33		4.96
0.11 to 219		4.93
0.28 to 118		4.84
0.29 to 113		4.90
0.83 to 25.60		4.30
0.25 to 94.93		4.24
0.59 to 26.83		4.01
0.37 to 40.12		3.95
0.64 to 20.45		3.89
0.65 to 19.67		3.86
0.55 to 23.08		3.78
0.51 to 25.30		3.78
0.62 to 19.90		3.77
0.61 to 20.02		3.76
0.42 to 32.39		3.69
0.40 to 58.42		3.61
0.47 to 23.28		3.64
0.46 to 26.13		3.62
0.42 to 27.24		3.52
0.46 to 22.44		3.56
0.38 to 59.91		3.48
0.49 to 21.34		3.31
0.47 to 21.07		3.27
0.53 to 17.67		3.18
0.45 to 19.16		3.20
0.24 to 36.96		3.02
0.53 to 14.50		2.84
0.45 to 15.57		2.77
0.35 to 18.40		2.70
0.19 to 35.75		2.65
0.41 to 13.53		2.46
0.43 to 11.76		2.41
0.29 to 17.41		2.20
0.38 to 12.04		2.14
0.33 to 11.78		2.01
0.10 to 31.21		2.03
0.36 to 11.11		1.74
0.06 to 56.43		1.69
0.05 to 53.23		1.73
0.29 to 8.68		1.69
0.14 to 18.65		1.61
0.13 to 19.02		1.57
0.20 to 14.96		1.49
0.24 to 8.07		1.24
0.19 to 7.55		1.22
0.21 to 6.63		1.17
0.10 to 10.57		1.06
0.04 to 34.61		1.06
0.03 to 33.26		1.01
0.15 to 6.88		LIXI_SC_5UG_BID0.85
0.07 to 9.02		0.80
0.02 to 35.30		0.69
0.06 to 7.11
DANU_PO_40MG_BID5.23
0.93 to 33.73		30.98
0.93 to 2485		28.94
2.15 to 487		20.48
1.56 to 326		17.31
2.24 to 158		17.22
1.50 to 266		17.26
0.37 to 1542		13.65
0.24 to 1807		13.32
0.21 to 1390		12.83
0.32 to 647		11.87
0.17 to 1624		10.62
0.11 to 1320		8.68
1.07 to 77.00		7.09
0.06 to 1225		6.59
0.83 to 61.36		6.38
0.44 to 86.51		6.24
0.74 to 65.62		5.91
0.13 to 283		5.56
0.71 to 90.24		5.55
0.72 to 82.90		5.56
0.89 to 41.43		5.16
0.27 to 126		4.90
0.70 to 39.01		4.62
0.40 to 56.39		4.53
0.72 to 32.45		4.52
0.74 to 30.49		4.48
0.64 to 34.86		4.50
0.58 to 39.26		4.39
0.68 to 31.20		4.33
0.67 to 34.10		4.31
0.50 to 45.15		4.42
0.31 to 111		4.24
0.55 to 35.36		4.23
0.52 to 38.54		4.13
0.46 to 41.78		4.05
0.54 to 34.68		4.25
0.31 to 97.61		4.04
0.57 to 31.08		3.85
0.52 to 30.49		3.81
0.60 to 27.65		3.72
0.52 to 29.49		3.76
0.28 to 52.03		3.49
0.61 to 23.39		3.26
0.49 to 24.57		3.15
0.42 to 28.27		3.05
0.24 to 49.85		3.04
0.50 to 21.46		2.84
0.48 to 19.54		2.78
0.31 to 26.36		2.57
0.33 to 22.21		2.51
0.36 to 18.83		2.35
0.11 to 43.28		2.39
0.30 to 21.49		2.06
0.06 to 71.54		2.04
0.06 to 70.69		1.98
0.32 to 13.63		1.97
0.16 to 26.07		1.83
0.38 to 10.92		1.87
0.17 to 28.34		1.73
0.26 to 12.76		1.44
0.19 to 12.03		1.42
0.23 to 10.12		1.36
0.12 to 14.63		1.21
0.04 to 48.58		1.25
0.04 to 42.53		1.19
0.11 to 14.81		1.18
0.11 to 13.51		DANU_PO_40MG_BID0.97
0.02 to 45.32		0.81
0.20 to 3.50
ORFO_PO_24MG_QD5.57
0.18 to 191		34.80
0.33 to 6603		31.49
0.59 to 1709		21.79
0.45 to 1130		18.36
0.50 to 751		18.69
0.42 to 971		18.52
0.16 to 4485		14.55
0.09 to 4303		12.80
0.17 to 2488		14.01
0.11 to 1669		11.43
0.16 to 2811		11.39
0.05 to 3275		9.01
0.24 to 370		7.73
0.03 to 2808		7.09
0.20 to 289		6.71
0.14 to 361		6.59
0.17 to 310		6.63
0.05 to 725		6.28
0.11 to 499		6.17
0.09 to 504		6.00
0.18 to 220		5.50
0.09 to 410		5.20
0.15 to 198		4.90
0.12 to 231		4.79
0.14 to 176		4.72
0.15 to 171		4.76
0.14 to 177		4.75
0.13 to 186		4.67
0.14 to 169		4.61
0.14 to 159		4.63
0.12 to 215		4.85
0.09 to 372		4.44
0.13 to 166		4.48
0.12 to 190		4.45
0.12 to 181		4.26
0.13 to 167		4.75
0.08 to 353		4.24
0.12 to 157		4.08
0.11 to 162		4.05
0.12 to 144		3.94
0.12 to 147		3.87
0.09 to 198		3.67
0.12 to 137		3.39
0.10 to 128		3.41
0.10 to 130		3.26
0.07 to 172		3.19
0.10 to 117		3.01
0.10 to 108		2.91
0.07 to 123		2.71
0.07 to 113		2.55
0.08 to 97.83		2.45
0.04 to 158		2.52
0.06 to 105		2.17
0.02 to 236		2.15
0.03 to 206		2.10
0.06 to 75.66		2.07
0.04 to 108		1.97
0.04 to 120		2.01
0.04 to 115		1.84
0.06 to 66.78		1.53
0.05 to 58.74		1.54
0.04 to 53.39		1.46
0.03 to 63.83		1.30
0.01 to 146		1.34
0.02 to 128		1.23
0.03 to 67.10		1.25
0.03 to 55.09		1.03
0.02 to 59.33		ORFO_PO_24MG_QD0.83
0.02 to 44.80
DANU_PO_80MG_BID6.41
1.23 to 39.86		37.94
1.24 to 3236		35.77
2.82 to 566		24.92
2.14 to 370		21.06
2.96 to 192		21.05
1.93 to 316		21.21
0.47 to 1866		16.81
0.32 to 2086		16.57
0.23 to 1727		15.63
0.40 to 818		14.66
0.21 to 1811		12.91
0.14 to 1724		10.53
1.44 to 91.52		8.82
0.07 to 1675		8.12
1.09 to 69.43		8.05
0.58 to 103		7.65
0.93 to 77.49		7.35
0.17 to 344		6.82
0.90 to 109		6.78
0.94 to 102		6.87
1.15 to 46.95		6.32
0.37 to 142		6.07
0.89 to 46.50		5.64
0.54 to 69.56		5.61
0.93 to 38.51		5.48
0.98 to 36.47		5.54
0.81 to 42.96		5.41
0.76 to 46.31		5.33
0.92 to 37.07		5.28
0.88 to 37.72		5.43
0.63 to 53.27		5.35
0.40 to 129		5.09
0.72 to 42.58		5.22
0.65 to 46.81		5.08
0.59 to 50.22		5.00
0.69 to 40.64		5.24
0.39 to 130		4.95
0.74 to 38.57		4.77
0.68 to 36.45		4.69
0.77 to 32.68		4.52
0.69 to 34.60		4.52
0.36 to 61.79		4.27
0.78 to 27.24		4.03
0.63 to 28.50		3.94
0.55 to 32.51		3.88
0.29 to 59.46		3.69
0.65 to 25.55		3.49
0.63 to 22.24		3.37
0.41 to 31.59		3.15
0.43 to 26.59		3.06
0.47 to 21.81		2.93
0.14 to 55.00		2.97
0.39 to 25.49		2.57
0.08 to 94.18		2.55
0.07 to 83.40		2.42
0.43 to 16.13		2.42
0.20 to 32.98		2.31
0.51 to 13.21		2.28
0.22 to 37.99		2.13
0.34 to 14.56		1.76
0.26 to 13.91		1.73
0.29 to 12.13		1.70
0.15 to 17.76		1.52
0.05 to 61.00		1.53
0.05 to 48.56		1.45
0.14 to 19.14		1.44
0.14 to 17.05		1.23
0.29 to 5.11		1.21
0.02 to 56.88		DANU_PO_80MG_BID

Heterogeneity, fit and convergence

Bayesian random effects (primary)

Heterogeneity (tau)
0.352 (95% CrI 0.179 to 0.571), log scale
Residual deviance
179.8 for 187 data points
DIC
311.7 (pD 131.8)
Largest R-hat
1.006
Smallest ESS
bulk 1,246, tail 2,781
Divergent transitions
0
Convergence
All criteria met
Priors
PR02 N(0, 5^2); PR05 N(0, 2.5^2); PR09 log normal(-2.1, 1.58^2) on tau^2 (Adverse events, pharm vs pharm)

Inconsistency

Do trials comparing two treatments directly agree with the indirect evidence through other treatments?

No comparison here has both direct and indirect evidence, so inconsistency cannot be checked by node splitting.

Small study effects

A comparison adjusted funnel plot: each point is one trial comparison, centered on its own network estimate. Asymmetry can signal that small trials with unfavorable results are missing.

Fewer than ten trial comparisons, too few to judge funnel plot asymmetry.

Baseline characteristics of the trials

The baseline value of each effect modifier or prognostic factor that applies here, per trial: mean or percent over arms, weighted by the number randomized. A note under a value names a stand in (a median for a mean, 100 minus the male share, Asian subgroup rows, an all Asian site list); "not reported" means no source of the trial prints it.
Baseline effect modifiers and prognostic factors per trial
TrialBaseline HbA1c (percent)
effect modifier, prognostic factor; 69 of 69
Background glucose lowering therapy (stratum S0 to S4)
effect modifier, prognostic factor; 65 of 69
NCT00754988
S000027
7.96S1
NCT02325960
S000058
8.18S1
NCT01296412
S000080
8.15S1
REWIND
S000147
7.35S4
STEP HFpEF DM
S000161
6.8
median
S4
PB119
S000217
8.5S0
NCT01001104
S000232
8.02S0
PIONEER 10
S000234
8.31S1
AWARD-7
S000237
8.6S3
NCT00717457
S000414
8.1S1
NCT00516074
S000435
7.31S1
NCT00082407
S000441
8.6S1
GETGOAL-L-ASIA
S000488
8.53S2
GETGOAL-S
S000491
8.26S1
NCT01175473
S000587
7.3S1
NCT03829891
S000676
9.21S1
PREVAIL
S000693
6.57S2
NCT00577824
S000752
8.22S1
GetGoal-Duo1
S000792
7.6S2
NCT01558271
S000837
8.14S0
NCT00849017
S000852
8.07S0
GRADE
S000873
7.5S1
GetGoal-O
S000904
8.04S4
NCT00135330
S000943
7.83S1
NCT02200991
S001003
8.29S2
AWARD-CHN1
S001064
7.97S0
NCT01733758
S001075
8.11S0
NCT05514535
S001161
7.9S2
NCT03985293
S001191
8.08S1
NCT00375492
S001222
7.62not reported
NCT04504396
S001230
8.47S1
NCT00360334
S001323
8.57S1
NCT04552470
S001336
8.37S0
SOLID-DKD
S001370
7.61S4
AWARD-CHN2
S001404
8.37S1
NCT02324842
S001422
8.2S1
GETGOAL-X
S001439
7.96S1
NCT00299871
S001455
7.55S1
LIGHT-ON
S001525
7.7S1
NCT00460941
S001597
7.9S1
NCT00744926
S001638
7.7S0
SUSTAIN 8
S001847
8.25S1
NCT02229227
S001887
7.7S3
NCT00382239
S001906
7.98S1
AGAC2
S001949
10.54S3
NCT01632163
S001963
7.9S2
NCT00676338
S001966
8.53S0
NCT05086445
S001999
7.88S0
AMPLITUDE-M
S002081
8.07S0
NCT02690883
S002088
9.05S2
GETGOAL-M
S002188
8.05S1
NCT01455441
S002225
8.11S1
NCT04466904
S002331
8.7S4
GETGOAL-MONO
S002333
8.03S0
S002885
S002885
9.5S1
S002946
S002946
6.45S1
S002969
S002969
6.74
median
S1
S002992
S002992
8.6S2
S003023
S003023
7.05S1
S003030
S003030
8.5S1
S003047
S003047
8.35S1
S003050
S003050
7.15S1
S003071
S003071
7.8S1
S003072
S003072
8not reported
S003090
S003090
8.1S3
S003100
S003100
6.64not reported
S003108
S003108
9.2S0
S003426
S003426
7.8S1
S003427
S003427
10.02not reported

Comparability of the trials

Checked across designs (the set of treatments each trial compares) for eligibility, outcome definition and assessment, and the baseline factors above. Flags point to possible intransitivity; notes describe variation that is not tied to design.
  • FlagBaseline, Baseline HbA1c: design means range from 6.5 (DULA_SC_0p75MG_QW vs SEMA_SC_0p5MG_QW) to 10.5 (EXEN_SC_5UG_BID vs PLACEBO) percent; threshold 0.5
  • FlagEligibility, hba1c entry range: a design requires hba1c 1000 or more while another admits only 7.5 or less
  • NoteOutcome assessment, intercurrent events (discontinuation): mixed: hypothetical 1, not stated 66, treatment_policy 1, while_on_treatment 1
  • NoteOutcome assessment, intercurrent events (rescue): mixed: hypothetical 1, not stated 66, treatment_policy 2
  • NoteRisk of bias, blinding: mixed: double_blind 35, not_reported 2, open_label 27, single_blind 5
  • NoteOutcome assessment, time point: selected time points span 0.43 to 386.13 weeks
  • NoteOutcome assessment, analysis set: mixed: completers 3, full_analysis 7, modified_itt 5, other 2, per_protocol 1, randomized 5, safety 46
  • NoteOutcome assessment, definition: mixed: adjudicated severe hypoglycemia while on assigned medication;measured glucose below 54 mg/dL in 30 days before any quarterly visit 1, adverse event term hypoglycemia, threshold not stated 1, all hypoglycemia, PG 70 mg/dL or less and/or symptoms, treatment period 1, Any hypoglycemia, including mild symptomatic 1, any hypoglycemic event, definition not given 1, any on therapy hypoglycemic event 1, Any signs or symptoms of hypoglycemia regardless of glucose 1, Hypoglycaemia reported as treatment emergent adverse event 1, Hypoglycemia adverse event of special interest 1, hypoglycemia adverse event, definition not stated 1, hypoglycemia adverse reaction, undefined 1, Hypoglycemia preferred term, mostly mild by investigator 1, hypoglycemia requiring third party assistance 1, hypoglycemia, definition not given 1, incidence of hypoglycemia, definition not given 1, investigator reported symptomatic hypoglycemia 1, level 3 severe hypoglycemia 2, Major: loss of consciousness or seizure, or glucose below 3.0 mmol/L needing assistance;Minor confirmed: symptoms with glucose below 3.0 mmol/L, self treated 1, mild hypoglycemia, undefined 1, not stated 18, participants whose worst on therapy event had glucose below 3.1 mmol/L 1, participants with capillary glucose 3.0 mmol/L or lower 1, patient reported hypoglycemia events 1, Patients declaring any hypoglycemia, definition not printed;Severe hypoglycemia, undefined, leading to discontinuation 1, patients with any glucose below 70 mg/dL 1, severe (ADA) or blood glucose confirmed below 3.1 mmol/L with symptoms 1, severe hypoglycemia 2, Severe hypoglycemia needing medical treatment 1, severe hypoglycemia needing third party assistance 1, severe hypoglycemia with severe cognitive impairment needing medical treatment 1, severe hypoglycemia, undefined 2, severe symptomatic hypoglycemia 1, severe symptomatic hypoglycemia needing assistance 1, severe symptomatic hypoglycemia needing assistance of another person, glucose below 2.0 mmol/L or prompt recovery 1, severe symptomatic needing assistance with glucose below 2.0 mmol/L or prompt recovery 1, severe symptomatic needing assistance with glucose below 2.0 mmol/L or prompt recovery;symptomatic with glucose below 3.3 mmol/L or prompt recovery after treatment 1, severe, assistance of another person required 1, severe, requiring assistance of another person 2, severe: third party assistance with glucose below 2.8 mmol/L or prompt recovery 1, symptomatic hypoglycemia with glucose below 3.3 mmol/L or prompt recovery 1, symptomatic hypoglycemia with glucose below 3.3 mmol/L or prompt recovery with carbohydrate 1, Symptomatic hypoglycemia with glucose below 60 mg/dL or symptoms without measurement 1, symptomatic hypoglycemia with plasma glucose below 3.3 mmol/L or prompt recovery with carbohydrate 1, symptomatic mild hypoglycemia, no glucose threshold printed 1, Symptoms or self monitored glucose below 3.4 mmol/L 1, TEAE preferred term hypoglycemia, not necessarily protocol defined 1, Zero implied by no hypoglycemia episodes of any kind 1, Zero implied by no hypoglycemia of any kind 1
  • NoteOutcome assessment, adjudicated: mixed: not stated 68, yes 1
  • NoteOutcome assessment, proportion method: mixed: not stated 67, observed 2
  • NoteRisk of bias, funding: mixed: industry 52, mixed 4, non_industry 11, not_reported 2
  • NoteData handling, input conversions: arms_combined 2, count_from_percent 6, nonserious_only 8, printed_denominator 21
Comparability items per trial
Trialstart yeartime weeksanalysis setdefinitioninstrumentadjudicatedproportion methodintercurrent events (discontinuation)intercurrent events (rescue)blindingfundingEligibility
NCT007549882008156safetyhypoglycemia adverse event, definition not statednot statednot statednot statednot statednot stateddouble_blindindustryage 18 to 75; HbA1c 7.0 to 10.0 percent; BMI 25 (23 Asian) to 45; metformin at least 1500 mg
NCT02325960201516safetynot statednot statednot statednot statednot statednot statedopen_labelmixedage 18 to 70; BMI 24 or more; HbA1c 7.0 to 10.0 percent; metformin 1.5 g/day or more
NCT01296412201126safetyinvestigator reported symptomatic hypoglycemianot statednot statednot statednot statednot statedopen_labelindustryage 18 to 79; HbA1c 7.0 to 11.0 percent on metformin 1500 mg or more; eGFR 60 or more
REWIND2011365.26safetynot statednot statednot statednot statednot statednot stateddouble_blindindustryage 50 or older with T2D; HbA1c 9.5 percent or less; BMI 23 or more; CV disease or risk factors
STEP HFpEF DM202157safetynot statednot statednot statednot statednot statednot stateddouble_blindindustryage 18 or older; heart failure with LVEF 45% or more; BMI 30 or more; type 2 diabetes with HbA1c 10% or less
PB119202024safetySevere hypoglycemia needing medical treatmentnot statednot statednot statednot statednot stateddouble_blindindustryage 18 to 75; HbA1c 7.5 to 11.0 at screening and 7.0 to 10.5 at randomization; BMI 18.5 to 40; eGFR 60 or more; drug naive
NCT01001104200912safetyall hypoglycemia, PG 70 mg/dL or less and/or symptoms, treatment periodnot statednot statednot statednot statednot stateddouble_blindindustryJapanese T2D age 20 to 74; BMI 18.5 to 40; HbA1c 7.0 to 9.5 percent after lead in
PIONEER 10201757safetysevere (ADA) or blood glucose confirmed below 3.1 mmol/L with symptomsnot statednot statednot statedwhile_on_treatmenttreatment_policysingle_blindindustryJapanese adults 20 or older; T2D; HbA1c 7.0 to 10.5 percent on one oral glucose lowering drug
AWARD-7201252safetyHypoglycaemia reported as treatment emergent adverse eventnot statednot statednot statedtreatment_policytreatment_policysingle_blindindustryadults with T2D and CKD stage 3 to 4 (eGFR 15 to below 60); HbA1c 7.5 to 10.5 percent on insulin; maximal ACEI or ARB; BMI 23 to 45
NCT007174572008104safetyadverse event term hypoglycemia, threshold not statednot statednot statednot statednot statednot statedopen_labelindustryage 18 to 75; HbA1c 7 to 10 percent; BMI 25 to 45 (above 23 for Asians); metformin with or without TZD
NCT00516074200712modified_ittsevere hypoglycemianot statednot statednot statednot statednot stateddouble_blindindustryage 18 to 75; HbA1c 6.5 to 9.5 percent; BMI 25 to 40; metformin and/or thiazolidinedione
NCT00082407200352modified_ittSymptoms or self monitored glucose below 3.4 mmol/Lnot statednot statedobservednot statednot statedopen_labelindustryAge 30 to 75; HbA1c 7.0 to 11.0 on metformin plus sulfonylurea; BMI 25 to 40
GETGOAL-L-ASIA200924safetysymptomatic hypoglycemia with glucose below 3.3 mmol/L or prompt recoverynot statednot statednot statednot statednot stateddouble_blindindustryage 25 to 81; type 2 diabetes at least 1 year; stable basal insulin at least 10 U/day with or without sulfonylurea; HbA1c 7 to 10 percent
GETGOAL-S2008120safetysevere symptomatic hypoglycemia needing assistancenot statednot statednot statednot statednot stateddouble_blindindustryadults on sulfonylurea with or without metformin; HbA1c 7 to 10 percent
NCT0117547320104.43safetynot statednot statednot statednot statednot statednot statedopen_labelindustryage 37 to 74; HbA1c 6.5 to 9.0 percent; BMI above 20 and below 37; metformin 1.5 g/day or more
NCT03829891201816full_analysispatient reported hypoglycemia eventsnot statednot statednot statednot statednot statedopen_labelnon_industryage 18 to 70; diabetes 6 months or more on stable oral agents; HbA1c 7.5 to 11.0 percent; BMI 21 to 35
PREVAIL201420modified_ittparticipants with capillary glucose 3.0 mmol/L or lowernot statednot statednot statednot statednot statedopen_labelnon_industryage 30 to 80; T2D 7 years or less; A1c 6.0 to 9.5 percent off drugs or 5.5 to 9.0 on up to 2 oral drugs
NCT00577824200824full_analysisAny signs or symptoms of hypoglycemia regardless of glucosenot statednot statednot statednot statednot stateddouble_blindindustryage 20 to 75; HbA1c 7.0 to 10.0 percent JDS; weight 50 kg or more; sulfonylurea based oral therapy
GetGoal-Duo1200924.43safetysevere symptomatic needing assistance with glucose below 2.0 mmol/L or prompt recovery;symptomatic with glucose below 3.3 mmol/L or prompt recovery after treatmentnot statednot statednot statednot statednot stateddouble_blindindustryT2D on metformin 1.5 g or more with or without SU, glinide or TZD, HbA1c 7 to 10, BMI over 20; HbA1c 7 to 9 after run in
NCT01558271201252safetysevere, assistance of another person requirednot statednot statednot statednot statednot stateddouble_blindindustryJapanese; age 20 or more; BMI 18.5 to 35; HbA1c 7.0 to 10.0 percent; OAM naive or OAM stopped
NCT008490172009164safetynot statednot statednot statednot statednot statednot stateddouble_blindindustryage 18 or older; HbA1c 7.0 to 10.0 percent; BMI 20 to 45; diet and exercise only
GRADE2013386.13per_protocoladjudicated severe hypoglycemia while on assigned medication;measured glucose below 54 mg/dL in 30 days before any quarterly visitnot statedyesnot statedhypotheticalhypotheticalsingle_blindmixedage at diagnosis 30 or older; T2D under 10 years; HbA1c 6.8 to 8.5 percent; metformin 1000 mg/day or more
GetGoal-O201324.43safetysevere symptomatic hypoglycemianot statednot statedobservednot statednot stateddouble_blindindustryage 70 or older; type 2 diabetes uncontrolled on basal insulin and/or oral drugs; eGFR 30 or higher
NCT00135330200520full_analysisincidence of hypoglycemia, definition not givennot statednot statednot statednot statednot statedopen_labelindustryage 18 to 75; BMI 25 to 40; HbA1c 6.8 to 10.0 percent; stable metformin only
NCT0220099120144.43safetysevere hypoglycemia needing third party assistancenot statednot statednot statednot statednot statedopen_labelindustryage 20 to 75; T2D 5 years or more; HbA1c 7.0 to 10.0; FBG 180 mg/dL or less; stable glargine
AWARD-CHN1201226safetysevere, requiring assistance of another personnot statednot statednot statednot statednot stateddouble_blindindustryage 18 or older; BMI 19 to 35 kg/m2; HbA1c 7.0 to 10.5 percent OAM naive or 6.5 to 10.0 percent on OAM monotherapy
NCT01733758201352safetyany on therapy hypoglycemic eventnot statednot statednot statednot statednot stateddouble_blindindustryJapanese adults; diet and exercise with or without one oral drug; HbA1c 7 to 10 percent after washout
NCT05514535202245safetylevel 3 severe hypoglycemianot statednot statednot statednot statednot statedopen_labelindustryadults with T2D, BMI 25 or more, HbA1c 7 to 10 percent, basal insulin up to 40 U/day plus metformin with or without SGLT2i
NCT03985293201920safetyTEAE preferred term hypoglycemia, not necessarily protocol definednot statednot statednot statednot statednot stateddouble_blindindustryage 18 to 75; HbA1c 7 to 10.5 percent; BMI 22.5 (Asia) or 24.5 to 45.4; metformin or diet and exercise
NCT00375492200624randomizedany hypoglycemic event, definition not givennot statednot statednot statednot statednot stateddouble_blindindustrytype 2 diabetes; weight loss trial
NCT04504396202024safetysevere hypoglycemia with severe cognitive impairment needing medical treatmentnot statednot statednot statednot statednot stateddouble_blindindustryage 18 to 75; HbA1c 7.0 to 10.5 percent; BMI 40 or lower; eGFR 60 or higher; metformin monotherapy at least 1000 mg
NCT00360334200626full_analysissevere: third party assistance with glucose below 2.8 mmol/L or prompt recoverynot statednot statednot statednot statednot statedopen_labelindustryBMI above 27; HbA1c 7.5 to 10.0 percent; 2 or 3 oral drugs; at least one CV risk factor
NCT04552470202012safetynot statednot statednot statednot statednot statednot stateddouble_blindindustryJapanese adults 20 to 70, diet and exercise only, HbA1c 7 to 10.5 percent, BMI 22.5 to 45.4
SOLID-DKD202418safetylevel 3 severe hypoglycemianot statednot statednot statednot statednot stateddouble_blindindustryage 18 to 75; T2D with UACR 300 to below 3000 mg/g; eGFR 30 or more; HbA1c 6.5 to 10; BMI 20 to 40
AWARD-CHN2201252safetysevere, requiring assistance of another personnot statednot statednot statednot statednot statedopen_labelindustryage 18 or older; BMI 19 to 35 kg/m2; HbA1c 7.0 to 11.0 percent on metformin and/or sulfonylurea
NCT02324842201417.38safetynot statednot statednot statednot statednot statednot statedopen_labelindustryT2DM, HbA1c 7 to 11 percent, eGFR 60 or more, drug naive or metformin with or without SU
GETGOAL-X2008116safetysevere symptomatic needing assistance with glucose below 2.0 mmol/L or prompt recoverynot statednot statednot statednot statednot statedopen_labelindustryage 21 to 84; HbA1c 7 to 10 percent; metformin at least 1.5 g/day
NCT00299871200613.43safetysymptomatic hypoglycemia with glucose below 3.3 mmol/L or prompt recovery with carbohydratenot statednot statednot statednot statednot stateddouble_blindindustryage 30 to 75; HbA1c 7.0 to below 9.0 percent on metformin at least 1000 mg/day
LIGHT-ON201426safetynot statednot statednot statednot statednot statednot statedopen_labelmixedage 30 to 75, HbA1c 6.5 to 10 percent on metformin, NAFLD with MRI-PDFF over 10 percent, BMI 20 to 35
NCT00460941200712safetysevere hypoglycemia, undefinednot statednot statednot statednot statednot stateddouble_blindindustryage 18 to 75; HbA1c 7.0 to 9.5 percent on metformin; BMI above 25 to 45
NCT00744926200824safetynot statednot statednot statednot statednot statednot stateddouble_blindindustryage 18 to 80; drug naive; HbA1c 6.5 to 10 percent; BMI 25 to 45
SUSTAIN 8201757safetynot statednot statednot statednot statednot statednot stateddouble_blindindustryage 18 or older; HbA1c 7.0 to 10.5 percent; eGFR 60 or higher; metformin 1500 mg or maximum tolerated
NCT02229227201426safetyparticipants whose worst on therapy event had glucose below 3.1 mmol/Lnot statednot statednot statednot statednot statedopen_labelindustryage 18 to 75; HbA1c 7.0 to 9.5 percent at screening; BMI 40 or less; basal plus prandial insulin
NCT00382239200612full_analysisHypoglycemia preferred term, mostly mild by investigatornot statednot statednot statednot statednot stateddouble_blindindustryage 20 to 75; HbA1c 7 to 10 percent on sulfonylurea based therapy; weight 50 kg or more
AGAC220110.43randomizedsevere hypoglycemianot statednot statednot statednot statednot statedopen_labelnon_industryage over 20, T2DM over 2 years, A1C 8 to 12 percent, premixed insulin twice daily over 0.6 U/kg/day
NCT01632163201224safetynot statednot statednot statednot statednot statednot stateddouble_blindindustryadults; T2D at least 1 year; HbA1c 7 to 10.5 at screening, 7 to 9.5 after run in; basal insulin at least 15 U
NCT00676338200826full_analysisMajor: loss of consciousness or seizure, or glucose below 3.0 mmol/L needing assistance;Minor confirmed: symptoms with glucose below 3.0 mmol/L, self treatednot statednot statednot statednot statednot stateddouble_blindindustryadults, HbA1c 7.1 to 11.0 percent, BMI 23 to 45 kg/m2, drug naive
NCT05086445202114safetyHypoglycemia adverse event of special interestnot statednot statednot statednot statednot stateddouble_blindindustryJapanese; age 20 to 70; BMI 20 to 35; HbA1c 7.0 to 10.0 diet only or 6.5 to 9.0 on one OAM, withdrawn 28 days
AMPLITUDE-M201756safetynot statednot statednot statednot statednot statednot stateddouble_blindindustrytype 2 diabetes on diet and exercise, HbA1c 7 to 10 percent, no glucose lowering drug in prior 3 months
NCT02690883201624safetyPatients declaring any hypoglycemia, definition not printed;Severe hypoglycemia, undefined, leading to discontinuationnot statednot statednot statednot statednot statedopen_labelindustryage 18 or older; eGFR 30 or more; UAER above 0.3 g/24 h
GETGOAL-M200876.43safetysevere symptomatic hypoglycemia needing assistance of another person, glucose below 2.0 mmol/L or prompt recoverynot statednot statednot statednot statednot stateddouble_blindindustrytype 2 diabetes on metformin 1.5 g/day or more for 3 months; HbA1c 7 to 10 percent; FPG 13.9 mmol/L or less
NCT01455441201116completersZero implied by no hypoglycemia episodes of any kindnot statednot statednot statednot statednot stateddouble_blindindustryage over 18; HbA1c 7 to 11 percent; BMI over 25; diet or metformin; sedentary
NCT04466904202020safetynot statednot statednot statednot statednot statednot stateddouble_blindindustryage 18 to 75; T2D on diet and exercise or stable metformin; HbA1c 7.5 to 11.0 percent; BMI 20 to 35
GETGOAL-MONO200812.43safetysymptomatic hypoglycemia with plasma glucose below 3.3 mmol/L or prompt recovery with carbohydratenot statednot statednot statednot statednot stateddouble_blindindustryage 20 to 85; HbA1c 7.0 to 10.0 percent; no glucose lowering drug for 3 months
S002885201912othersymptomatic mild hypoglycemia, no glucose threshold printednot statednot statednot statednot statednot statedopen_labelnon_industryage 20 to 75; HbA1c 7.0 or more on metformin and glimepiride; eGFR 30 or more
S002946202026randomizedZero implied by no hypoglycemia of any kindnot statednot statednot statednot statednot statedopen_labelnot_reportedage over 20; T2D on liraglutide 0.6 or 0.9 mg; no new diabetes drug for 3 months
S002969201852.14safetynot statednot statednot statednot statednot statednot stateddouble_blindindustryage 18 to 70; BMI 30 to 50; HbA1c 48 to below 97 mmol/mol; T2DM under 10 years; undergoing LAGB
S00299226safetynot statednot statednot statednot statednot statednot statedopen_labelindustryadults 18 or older; HbA1c 7.5 to 10 percent; BMI 20 to less than 40; basal insulin 20 to 50 U plus metformin with or without SGLT2i
S0030230.43modified_ittnot statednot statednot statednot statednot statednot statedsingle_blindnon_industryage 20 to 80, T2D not on insulin, elective CABG or valve surgery with cardiopulmonary bypass
S003030201552full_analysissevere hypoglycemia, undefinednot statednot statednot statednot statednot statedopen_labelindustryage 20 to 75; HbA1c 7.5 to 11 percent; two or more oral agents for 3 months
S00304720066.57safetySymptomatic hypoglycemia with glucose below 60 mg/dL or symptoms without measurementnot statednot statednot statednot statednot stateddouble_blindindustryage 20 to 75; HbA1c 7.0 to 10.0 percent; BMI 35 or less; sulfonylurea with or without metformin
S003050202012safetynot statednot statednot statednot statednot statednot statednot_reportednon_industryage 18 to 65; diabetes 2 years or less, no ASCVD; HbA1c 7.0 to 7.5 percent; BMI 18.5 to 30; metformin 1000 mg
S003071201024randomizedhypoglycemia requiring third party assistancenot statednot statednot statednot statednot statedopen_labelnon_industryage 18 to under 80; HbA1c 6.9 to 9.4 percent NGSP; BMI 35 or less; on sulfonylurea
S003072201114completersnot statednot statednot statednot statednot statednot statedopen_labelmixedage 20 to 80; HbA1c above 6.9 percent on sitagliptin 50 mg for 3 months or more
S0030901modified_ittpatients with any glucose below 70 mg/dLnot statednot statednot statednot statednot statedopen_labelnot_reportedage over 18; type 2 diabetes over 3 months; noncritical inpatients; prior insulin under 10 units/day
S003100201913.04completershypoglycemia, definition not givennot statednot statednot statednot statednot statedopen_labelnon_industryage 18 to 75; T2D; OSA with AHI above 15 on CPAP; no DPP4i or GLP-1 RA
S003108201224randomizedAny hypoglycemia, including mild symptomaticnot statednot statednot statednot statednot statedsingle_blindnon_industryT2D with coronary artery disease; no severe heart failure; creatinine up to 150 umol/L
S00342624safetymild hypoglycemia, undefinednot statednot statednot statednot statednot statedopen_labelnon_industryadults with type 2 diabetes; HbA1c 6.5 to 8.0 percent; BMI 30 to 35; stable metformin and empagliflozin
S003427201952.14otherhypoglycemia adverse reaction, undefinednot statednot statednot statednot statednot statednot_reportednon_industryadults with type 2 diabetes, stable treatment, measurable CIMT; no prior CVD events

Trial data

What each trial contributes. Arm rows give the arm value with its standard error, or events over participants; contrast rows give the hazard ratio (from event counts) on the analysis scale (log) against the trial's first row. Flags mark converted, combined or approximated inputs.
Trial data entering this analysis
TrialArmTreatmentWeekDataValueSEEvents / NFlagsSource
NCT00754988A2TASP_SC_10MG_QW156arm, events21 / 190R0022521:Table 2
NCT00754988A3TASP_SC_20MG_QW156arm, events15 / 198R0022521:Table 2
NCT00754988A4SITAGLIPTIN156arm, events18 / 185R0022521:Table 2
NCT02325960A1EXEN_SC_10UG_BID16arm, events0 / 22R0024438:Results
NCT02325960A2INS_GLARGINE16arm, events0 / 23R0024438:Results
NCT01296412A1SITAGLIPTIN26arm, events39 / 326R0026295:Table 3
NCT01296412A2LIRA_SC_FLEX_1p2-1p8_QD26arm, events13 / 327R0026295:Table 3
REWINDA1PLACEBO365.26arm, events354 / 4,952nonserious_onlyregistry:adverse_events
REWINDA2DULA_SC_1p5MG_QW365.26arm, events413 / 4,949nonserious_onlyregistry:adverse_events
STEP HFpEF DMA1SEMA_SC_2p4MG_QW57arm, events30 / 310R0018972:Table 4
STEP HFpEF DMA2PLACEBO57arm, events21 / 306R0018972:Table 4
PB119A1VISEPE_SC_150UG_QW24arm, events6 / 137R0011471:Table 4
PB119A2PLACEBO24arm, events1 / 136R0011471:Table 4
NCT01001104A1PLACEBO12arm, events0 / 37R0015000:Table 3
NCT01001104A2DULA_SC_0p25MG_QW12arm, events0 / 36R0015000:Table 3
NCT01001104A3DULA_SC_0p5MG_QW12arm, events1 / 37R0015000:Table 3
NCT01001104A4DULA_SC_0p75MG_QW12arm, events2 / 35R0015000:Table 3
PIONEER 10A1SEMA_PO_3MG_QD57arm, events14 / 131R0018421:Table 3
PIONEER 10A2SEMA_PO_7MG_QD57arm, events26 / 132R0018421:Table 3
PIONEER 10A3SEMA_PO_14MG_QD57arm, events27 / 130R0018421:Table 3
PIONEER 10A4DULA_SC_0p75MG_QW57arm, events13 / 65R0018421:Table 3
AWARD-7A1INS_GLARGINE52arm, events16 / 194R0017387:Table 2
AWARD-7A2DULA_SC_0p75MG_QW52arm, events9 / 190R0017387:Table 2
AWARD-7A3DULA_SC_1p5MG_QW52arm, events3 / 193R0017387:Table 2
NCT00717457A1TASP_SC_10MG_QW104arm, events59 / 399R0013639:Table 2
NCT00717457A2TASP_SC_20MG_QW104arm, events60 / 398R0013639:Table 2
NCT00717457A3EXEN_SC_10UG_BID104arm, events79 / 392R0013639:Table 2
NCT00516074A1EXEN_SC_10UG_BID12arm, events2 / 28count_from_percentR0019195:Results
NCT00516074A2PLACEBO12arm, events1 / 26count_from_percentR0019195:Results
NCT00082407A1EXEN_SC_10UG_BID52arm, events134 / 255count_from_percentregistry:outcomes
NCT00082407A2INS_PREMIX52arm, events128 / 250count_from_percentregistry:outcomes
GETGOAL-L-ASIAA1LIXI_SC_20UG_QD24arm, events66 / 154R0022626:Table 2
GETGOAL-L-ASIAA2PLACEBO24arm, events37 / 157R0022626:Table 2
GETGOAL-SA1PLACEBO120arm, events51 / 286registry:outcomes
GETGOAL-SA2LIXI_SC_20UG_QD120arm, events127 / 573registry:outcomes
NCT01175473A1LIXI_SC_20UG_QD4.43arm, events0 / 77R0022723:Table 3
NCT01175473A2LIRA_SC_1p8MG_QD4.43arm, events0 / 71R0022723:Table 3
NCT03829891A1BEIN_SC_0p2MG_TID16arm, events5 / 35R0007581:Results
NCT03829891A2INS_GLARGINE16arm, events9 / 33R0007581:Results
PREVAILA1STANDARD_CARE20arm, events15 / 33R0010144:Table 3
PREVAILA2INS_LISPRO20arm, events12 / 35R0010144:Table 3
PREVAILA3EXEN_SC_10UG_BID20arm, events6 / 35R0010144:Table 3
NCT00577824A1PLACEBO24arm, events8 / 36R0018881:Table 2
NCT00577824A2EXEN_SC_5UG_BID24arm, events37 / 72R0018881:Table 2
NCT00577824A3EXEN_SC_10UG_BID24arm, events42 / 73R0018881:Table 2
GetGoal-Duo1A1PLACEBO24.43arm, events30 / 223registry:outcomes
GetGoal-Duo1A2LIXI_SC_20UG_QD24.43arm, events50 / 223registry:outcomes
NCT01558271A1DULA_SC_0p75MG_QW52arm, events8 / 281R0011754:Results
NCT01558271A2LIRA_SC_0p9MG_QD52arm, events4 / 141R0011754:Results
NCT00849017A1PLACEBO164arm, events8 / 105nonserious_onlyregistry:adverse_events
NCT00849017A2ALBI_SC_30MG_QW164arm, events6 / 102nonserious_onlyregistry:adverse_events
NCT00849017A3ALBI_SC_50MG_QW164arm, events9 / 102nonserious_onlyregistry:adverse_events
GRADEA1INS_GLARGINE386.13arm, events659 / 1,263R0020895:Table 2
GRADEA2GLIMEPIRIDE386.13arm, events833 / 1,254R0020895:Table 2
GRADEA3LIRA_SC_1p8MG_QD386.13arm, events375 / 1,262R0020895:Table 2
GRADEA4SITAGLIPTIN386.13arm, events361 / 1,268R0020895:Table 2
GetGoal-OA1LIXI_SC_20UG_QD24.43arm, events13 / 176count_from_percentregistry:outcomes
GetGoal-OA2PLACEBO24.43arm, events10 / 174count_from_percentregistry:outcomes
NCT00135330A1EXEN_SC_10UG_BID20arm, events8 / 45registry:outcomes
NCT00135330A2EXENROSI_SC_10-4UG_BID20arm, events9 / 47registry:outcomes
NCT00135330A3ROSIGLITAZONE20arm, events6 / 45registry:outcomes
NCT02200991A1LIXI_SC_20UG_QD4.43arm, events11 / 69R0024589:Table 3
NCT02200991A2SITAGLIPTIN4.43arm, events1 / 67R0024589:Table 3
AWARD-CHN1A1DULA_SC_1p5MG_QW26arm, events14 / 244R0014229:Table 2
AWARD-CHN1A2DULA_SC_0p75MG_QW26arm, events9 / 248R0014229:Table 2
AWARD-CHN1A3GLIMEPIRIDE26arm, events38 / 245R0014229:Table 2
NCT01733758A2ALBI_SC_30MG_QW52arm, events8 / 160printed_denominatorR0010997:Results
NCT01733758A3ALBI_SC_50MG_QW52arm, events6 / 150printed_denominatorR0010997:Results
NCT01733758A4LIRA_SC_0p9MG_QD52arm, events3 / 103printed_denominatorR0010997:Results
NCT05514535A1SEMA_SC_2p0MG_QW45arm, events14 / 288R0015842:Table 2
NCT05514535A2INS_GLARGINE45arm, events21 / 285R0015842:Table 2
NCT03985293A1PLACEBO20arm, events0 / 66R0006095:Table 3
NCT03985293A2DANU_PO_2p5MG_BID20arm, events1 / 68R0006095:Table 3
NCT03985293A3DANU_PO_10MG_BID20arm, events1 / 68R0006095:Table 3
NCT03985293A4DANU_PO_40MG_BID20arm, events4 / 71R0006095:Table 3
NCT03985293A5DANU_PO_80MG_BID20arm, events6 / 67R0006095:Table 3
NCT03985293A6DANU_PO_120MG_BID20arm, events3 / 72R0006095:Table 3
NCT00375492A1EXEN_SC_10UG_BID24arm, events33 / 96registry:outcomes
NCT00375492A2PLACEBO24arm, events30 / 98registry:outcomes
NCT04504396A1VISEPE_SC_150UG_QW24arm, events8 / 310R0009432:Table 3
NCT04504396A2PLACEBO24arm, events10 / 310R0009432:Table 3
NCT00360334A1EXEN_SC_10UG_BID26arm, events37 / 118R0024925:Table 3
NCT00360334A2INS_GLARGINE26arm, events68 / 117R0024925:Table 3
NCT04552470A1PLACEBO12arm, events0 / 9R0004540:Results
NCT04552470A2DANU_PO_40MG_BID12arm, events1 / 10R0004540:Results
NCT04552470A3DANU_PO_80MG_BID12arm, events0 / 9R0004540:Results
NCT04552470A4DANU_PO_120MG_BID12arm, events0 / 9R0004540:Results
SOLID-DKDA1HRS7535_PO_30MG_QD18arm, events8 / 93R0004355:Table 2
SOLID-DKDA2HRS7535_PO_90MG_QD18arm, events2 / 94R0004355:Table 2
SOLID-DKDA3PLACEBO18arm, events2 / 94R0004355:Table 2
AWARD-CHN2A1DULA_SC_1p5MG_QW52arm, events58 / 258R0023722:Table 2
AWARD-CHN2A2DULA_SC_0p75MG_QW52arm, events51 / 257R0023722:Table 2
AWARD-CHN2A3INS_GLARGINE52arm, events88 / 259R0023722:Table 2
NCT02324842A1CANAGLIFLOZIN17.38arm, events0 / 15nonserious_onlyregistry:adverse_events
NCT02324842A2LIRA_SC_1p8MG_QD17.38arm, events3 / 15nonserious_onlyregistry:adverse_events
NCT02324842A3CANALIRA_SC_1p8-300MG_QD17.38arm, events3 / 15nonserious_onlyregistry:adverse_events
GETGOAL-XA1LIXI_SC_20UG_QD116arm, events16 / 320registry:outcomes
GETGOAL-XA2EXEN_SC_10UG_BID116arm, events46 / 319registry:outcomes
NCT00299871A1PLACEBO13.43arm, events1 / 109R0021613:Table 3
NCT00299871A2LIXI_SC_5UG_QD13.43arm, events1 / 55R0021613:Table 3
NCT00299871A3LIXI_SC_10UG_QD13.43arm, events2 / 52R0021613:Table 3
NCT00299871A4LIXI_SC_20UG_QD13.43arm, events1 / 55R0021613:Table 3
NCT00299871A5LIXI_SC_30UG_QD13.43arm, events1 / 54R0021613:Table 3
NCT00299871A6LIXI_SC_5UG_BID13.43arm, events3 / 53R0021613:Table 3
NCT00299871A7LIXI_SC_10UG_BID13.43arm, events1 / 56R0021613:Table 3
NCT00299871A8LIXI_SC_20UG_BID13.43arm, events3 / 54R0021613:Table 3
NCT00299871A9LIXI_SC_30UG_BID13.43arm, events1 / 54R0021613:Table 3
LIGHT-ONA1LIRA_SC_1p8MG_QD26arm, events0 / 24R0024860:Table 5
LIGHT-ONA2SITAGLIPTIN26arm, events1 / 27R0024860:Table 5
LIGHT-ONA3INS_GLARGINE26arm, events2 / 24R0024860:Table 5
NCT00460941A1PLACEBO12arm, events1 / 32printed_denominatorR0021258:Results
NCT00460941A2TASP_SC_20MG_QW12arm, events1 / 32printed_denominatorR0021258:Results
NCT00460941A3TASP_SC_30MG_QW12arm, events3 / 33printed_denominatorR0021258:Results
NCT00460941A4TASP_SC_40MG_QW12arm, events2 / 32printed_denominatorR0021258:Results
NCT00744926A1PLACEBO24arm, events1 / 123printed_denominatorR0025346:Table 1
NCT00744926A2TASP_SC_10MG_QW24arm, events6 / 116printed_denominatorR0025346:Table 1
NCT00744926A3TASP_SC_20MG_QW24arm, events5 / 129printed_denominatorR0025346:Table 1
SUSTAIN 8A1SEMA_SC_1p0MG_QW57arm, events6 / 394registry:outcomes
SUSTAIN 8A2CANAGLIFLOZIN57arm, events5 / 394registry:outcomes
NCT02229227A1ALBI_SC_50MG_QW26arm, events230 / 402R0008089:Table 3
NCT02229227A2INS_LISPRO26arm, events309 / 412R0008089:Table 3
NCT00382239A1PLACEBO12arm, events4 / 40R0027621:Table 3
NCT00382239A2EXEN_SC_2p5UG_BID12arm, events10 / 38R0027621:Table 3
NCT00382239A3EXEN_SC_5UG_BID12arm, events16 / 37R0027621:Table 3
NCT00382239A4EXEN_SC_10UG_BID12arm, events20 / 38R0027621:Table 3
AGAC2A1PLACEBO0.43arm, events9 / 21R0020827:Supplementary Table 2
AGAC2A2EXEN_SC_5UG_BID0.43arm, events12 / 30R0020827:Supplementary Table 2
NCT01632163A1LIXI_SC_20UG_QD24arm, events35 / 224R0014725:Results
NCT01632163A2PLACEBO24arm, events30 / 224R0014725:Results
NCT00676338A1EXENER_SC_2MG_QW26arm, events13 / 248R0027761:Results
NCT00676338A2METFORMIN26arm, events10 / 246R0027761:Results
NCT00676338A3PIOGLITAZONE26arm, events6 / 163R0027761:Results
NCT00676338A4SITAGLIPTIN26arm, events5 / 163R0027761:Results
NCT05086445A1PLACEBO14arm, events0 / 11R0003844:Table 2
NCT05086445A2ORFO_PO_12MG_QD14arm, events0 / 14R0003844:Table 2
NCT05086445A3ORFO_PO_24MG_QD14arm, events1 / 17R0003844:Table 2
NCT05086445A4ORFO_PO_45MG_QD14arm, events0 / 18R0003844:Table 2
AMPLITUDE-MA1EFPE_SC_2MG_QW56arm, events0 / 100R0007136:Table 2
AMPLITUDE-MA2EFPE_SC_4MG_QW56arm, events1 / 101R0007136:Table 2
AMPLITUDE-MA3EFPE_SC_6MG_QW56arm, events1 / 103R0007136:Table 2
AMPLITUDE-MA4PLACEBO56arm, events0 / 102R0007136:Table 2
NCT02690883A1INS_LISPRO24arm, events20 / 46R0011086:Results
NCT02690883A2EXEN_SC_10UG_BID24arm, events10 / 46R0011086:Results
GETGOAL-MA1+A2LIXI_SC_20UG_QD76.43arm, events40 / 510arms_combinedregistry:outcomes
GETGOAL-MA3PLACEBO76.43arm, events4 / 170printed_denominatorregistry:outcomes
NCT01455441A1LIRA_SC_1p8MG_QD16arm, events0 / 18R0010221:Results
NCT01455441A2PLACEBO16arm, events0 / 16R0010221:Results
NCT04466904A1MAZD_SC_3MG_QW20arm, events1 / 8R0009340:Table 2
NCT04466904A2MAZD_SC_4p5MG_QW20arm, events0 / 8R0009340:Table 2
NCT04466904A3MAZD_SC_6MG_QW20arm, events1 / 8R0009340:Table 2
NCT04466904A4DULA_SC_1p5MG_QW20arm, events0 / 6printed_denominatorR0009340:Table 2
NCT04466904A5PLACEBO20arm, events0 / 12printed_denominatorR0009340:Table 2
GETGOAL-MONOA1PLACEBO12.43arm, events2 / 122printed_denominatorR0022843:Table 2
GETGOAL-MONOA2+A3LIXI_SC_20UG_QD12.43arm, events4 / 239arms_combinedR0022843:Table 2
S002885A1DULA_SC_1p5MG_QW12arm, events1 / 13R0003420:Results
S002885A2EMPAGLIFLOZIN12arm, events2 / 12R0003420:Results
S002946A1SEMA_SC_0p5MG_QW26arm, events0 / 16R0006360:Supplement Table S2
S002946A2DULA_SC_0p75MG_QW26arm, events0 / 16R0006360:Supplement Table S2
S002969A1LIRA_SC_1p8MG_QD52.14arm, events0 / 13R0010852:Supplementary Clinical Sequelae 1
S002969A2PLACEBO52.14arm, events1 / 14R0010852:Supplementary Clinical Sequelae 1
S002992A1IGLARLIXI2_SC_TIT_QD26arm, events114 / 443R0019745:Figure 1
S002992A2INS_PREMIX26arm, events170 / 444R0019745:Figure 1
S003023A1LIRA_SC_1p2MG_OTHER0.43arm, events0 / 32printed_denominatorR0017408:Results
S003023A2STANDARD_CARE0.43arm, events0 / 28printed_denominatorR0017408:Results
S003030A1EXEN_SC_10UG_BID52arm, events1 / 33R0018574:Results
S003030A2INS_PREMIX52arm, events5 / 33R0018574:Results
S003047A1LIXI_SC_30UG_QD6.57arm, events8 / 39printed_denominatorR0016337:Table 3
S003047A2LIXI_SC_30UG_BID6.57arm, events9 / 41printed_denominatorR0016337:Table 3
S003047A3PLACEBO6.57arm, events3 / 40printed_denominatorR0016337:Table 3
S003050A1METFORMIN12arm, events0 / 30R0021314:Results
S003050A2DULA_SC_1p5MG_QW12arm, events0 / 30R0021314:Results
S003071A1LIRA_SC_0p9MG_QD24arm, events9 / 50R0023696:Results
S003071A2SITAGLIPTIN24arm, events5 / 49R0023696:Results
S003072A1VILDAGLIPTIN14arm, events0 / 62R0023470:Results
S003072A2LIRA_SC_0p9MG_QD14arm, events0 / 60R0023470:Results
S003090A1STANDARD_CARE1arm, events1 / 27printed_denominatorR0025350:Table 3
S003090A2DULA_SC_0p75MG_QW1arm, events0 / 27printed_denominatorR0025350:Table 3
S003100A1LIRA_SC_1p8MG_QD13.04arm, events2 / 45R0021058:Table 5
S003100A2STANDARD_CARE13.04arm, events1 / 45R0021058:Table 5
S003108A1LIRA_SC_FLEX_0p6-1p2-1p8_QD24arm, events1 / 30R0025278:Table 4
S003108A2METFORMIN24arm, events1 / 30R0025278:Table 4
S003108A3LIRA_SC_1p8MG_QD24arm, events4 / 30R0025278:Table 4
S003108A4LIRAMETF_SC_1p2-1500MG_QD24arm, events3 / 30R0025278:Table 4
S003426A1SEMA_SC_0p5MG_QW24arm, events1 / 38R0040396:Table 3
S003426A2TIRZ_SC_5MG_QW24arm, events2 / 41R0040396:Table 3
S003427A1LIRA_SC_FLEX_0p6-1p2-1p8_QD52.14arm, events3 / 74R0044046:Table IV
S003427A2SEMA_SC_1p0MG_QW52.14arm, events3 / 74R0044046:Table IV

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