parallel randomized trial

S003090

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

Type 2 diabetes (adults)S003090

Design

Randomized
Start year
Treatment: 1 weeks, follow-up 1 weeks
Countries: Japan (1 sites)
Sponsor: (not reported)
Eligibility: age over 18; type 2 diabetes over 3 months; noncritical inpatients; prior insulin under 10 units/day

Conduct and analysis

Blinding: open label
Sequence generation: not reported
Allocation concealment: not reported
Outcome adjudication: not reported
Primary estimand: not stated
Analysis population: modified itt
Missing data

Arms

Arm	Treatment	Background	Randomized	Analyzed	Completed treatment
A1	Standard care or no added treatment Basal plus (glargine)	insulin glargine once daily titrated to fasting glucose 100 to 140 mg/dL plus correction regular insulin before meals; oral agents stopped; lifestyle: not reported		27
A2	Dulaglutide 0.75 mg subcutaneous once weekly Basal plus with dulaglutide	insulin glargine plus correction regular insulin before meals; oral agents stopped; lifestyle: not reported		27

Baseline characteristics

As printed in the trial reports or registry, per arm or for the whole trial.

Characteristic	Statistic	Standard care or no added treatment A1	Dulaglutide 0.75 mg subcutaneous once weekly A2
age	mean (years)	70.1	70.9
age	sd (years)	14	13
bmi	mean (kg/m2)	24.6	25.1
bmi	sd (kg/m2)	5.7	6.7
diabetes duration	mean (years)	10.1	8.7
diabetes duration	sd (years)	8.8	9.4
hba1c	mean (percent)	8.0	8.2
hba1c	sd (percent)	1.9	1.7
other male	n	18	15
other male	percent	67	56

Analyses this trial contributes to

Results

6 adjudicated result lines, grouped by outcome. Open an outcome to see its values.

Level 2 or 3 hypoglycemia (participants) (6 lines; O04)

Arm	Statistic	Events / N	Detail
A1	events	9 / 27	not stated; modified itt; R0025350:Table 3
A1	events	1 / 27	not stated; modified itt; R0025350:Table 3
A1	events	6 / 27	not stated; modified itt; R0025350:Table 3
A2	events	3 / 27	not stated; modified itt; R0025350:Table 3
A2	events	0 / 27	not stated; modified itt; R0025350:Table 3
A2	events	1 / 27	not stated; modified itt; R0025350:Table 3