LivingGLP1
Short acting GLP-1 receptor agonist (injectable)

Exenatide 2.5 µg injection twice daily

EXEN_SC_2p5UG_BID

Mechanism
GLP-1 receptor agonist; exenatide twice daily and lixisenatide (half life about 2 to 4 hours); beinaglutide (recombinant human GLP-1; half life of minutes)
Trials
1
Participants in these arms
38

Effects across outcomes

Bayesian random effects estimate against the comparator of each analysis (usually placebo), posterior median and 95% credible interval. Green: clearly better; red: clearly worse.
ConditionOutcomeWindowVersusEffect (95% CrI)SUCRA
Type 2 diabetes (adults)Level 2 or 3 hypoglycemia (participants)longest follow-upPlaceboHR 1.07 (0.41 to 2.72)0.60
Type 2 diabetes (adults)Serious adverse eventslongest follow-upPlaceboHR 5.22 (0.20 to 142)0.18
Type 2 diabetes (adults)Nausealongest follow-upPlaceboHR 1.57 (0.41 to 4.84)0.66
Type 2 diabetes (adults)Vomitinglongest follow-upPlaceboHR 1.29 (0.20 to 5.61)0.68
Type 2 diabetes (adults)Diarrhealongest follow-upPlaceboHR 0.58 (0.05 to 3.52)0.78
Type 2 diabetes (adults)Constipationlongest follow-upPlaceboHR 1.87 (0.47 to 6.34)0.45
Type 2 diabetes (adults)Acute pancreatitislongest follow-upPlaceboHR 0.86 (0.05 to 13.28)0.47

Trials