LivingGLP1
parallel randomized trial

S003442

Design

Randomized
96
Start year
2019
Treatment
24 weeks, follow-up 24 weeks
Countries
Sponsor
(non industry)
Eligibility
Women with T2D by ADA criteria; no weight loss drugs within 24 weeks

Conduct and analysis

Blinding
not reported
Sequence generation
computer
Allocation concealment
central
Outcome adjudication
not reported
Primary estimand
not stated
Analysis population
Missing data

Arms

ArmTreatmentBackgroundRandomizedAnalyzedCompleted treatment
A1Dulaglutide flexible dose injection once weekly
Dulaglutide (observation group)
none; lifestyle: standard48
A2Liraglutide 1.2 mg subcutaneous once daily
Liraglutide (control group)
none; lifestyle: standard48

Baseline characteristics

As printed in the trial reports or registry, per arm or for the whole trial.
CharacteristicStatisticDulaglutide flexible dose injection once weekly
A1
Liraglutide 1.2 mg subcutaneous once daily
A2
Whole trial
ALL
agemax (years)69
agemean (years)46.14
agemin (years)23
agesd (years)5.78
bmimax (kg/m2)29.34
bmimean (kg/m2)22.62
bmimin (kg/m2)18.31
bmisd (kg/m2)3.71
diabetes durationmax (years)12
diabetes durationmean (years)5.73
diabetes durationmin (years)1
diabetes durationsd (years)0.92
femalen96
hba1cmean (percent)7.897.92
hba1csd (percent)0.930.96

Analyses this trial contributes to

Results

12 adjudicated result lines, grouped by outcome. Open an outcome to see its values.
HbA1c change (2 lines; O01)
WeekArmStatisticEstimateSE or SD95% CIEvents / NDetail
24A1final5.67 percent0.7148not stated; other; R0016372:Table 1
24A2final6.74 percent0.8248not stated; other; R0016372:Table 1
Level 2 or 3 hypoglycemia (participants) (2 lines; O04)
WeekArmStatisticEstimateSE or SD95% CIEvents / NDetail
A1events1 / 48not stated; other; R0016372:Table 4
A2events2 / 48not stated; other; R0016372:Table 4
Discontinuation due to adverse events (2 lines; O26)
WeekArmStatisticEstimateSE or SD95% CIEvents / NDetail
A1events0 / 48not stated; other; R0016372:Results
A2events0 / 48not stated; other; R0016372:Results
Nausea (2 lines; O27A)
WeekArmStatisticEstimateSE or SD95% CIEvents / NDetail
A1events0 / 48not stated; other; nausea and vomiting; R0016372:Table 4
A2events2 / 48not stated; other; nausea and vomiting; R0016372:Table 4
Discontinuation due to gastrointestinal adverse events (2 lines; O27E)
WeekArmStatisticEstimateSE or SD95% CIEvents / NDetail
A1events0 / 48not stated; other; R0016372:Results
A2events0 / 48not stated; other; R0016372:Results
Gallbladder and biliary disease (2 lines; O28)
WeekArmStatisticEstimateSE or SD95% CIEvents / NDetail
A1events0 / 48not stated; other; cholecystitis; R0016372:Table 4
A2events2 / 48not stated; other; cholecystitis; R0016372:Table 4