parallel randomized trial
S003442
Type 2 diabetes (adults)S003442
Design
Conduct and analysis
Arms
| Arm | Treatment | Background | Randomized | Analyzed | Completed treatment |
|---|---|---|---|---|---|
| A1 | Dulaglutide flexible dose injection once weekly Dulaglutide (observation group) | none; lifestyle: standard | 48 | ||
| A2 | Liraglutide 1.2 mg subcutaneous once daily Liraglutide (control group) | none; lifestyle: standard | 48 |
Baseline characteristics
As printed in the trial reports or registry, per arm or for the whole trial.
| Characteristic | Statistic | Dulaglutide flexible dose injection once weekly A1 | Liraglutide 1.2 mg subcutaneous once daily A2 | Whole trial ALL |
|---|---|---|---|---|
| age | max (years) | 69 | ||
| age | mean (years) | 46.14 | ||
| age | min (years) | 23 | ||
| age | sd (years) | 5.78 | ||
| bmi | max (kg/m2) | 29.34 | ||
| bmi | mean (kg/m2) | 22.62 | ||
| bmi | min (kg/m2) | 18.31 | ||
| bmi | sd (kg/m2) | 3.71 | ||
| diabetes duration | max (years) | 12 | ||
| diabetes duration | mean (years) | 5.73 | ||
| diabetes duration | min (years) | 1 | ||
| diabetes duration | sd (years) | 0.92 | ||
| female | n | 96 | ||
| hba1c | mean (percent) | 7.89 | 7.92 | |
| hba1c | sd (percent) | 0.93 | 0.96 |
Analyses this trial contributes to
- HbA1c changeType 2 diabetes (adults); weeks 20 to 36 (target week 26); network meta-analysis
- HbA1c changeType 2 diabetes (adults); weeks 20 to 36 (target week 26); descriptive only
- Level 2 or 3 hypoglycemia (participants)Type 2 diabetes (adults); longest follow-up; network meta-analysis
- Level 2 or 3 hypoglycemia (participants)Type 2 diabetes (adults); longest follow-up; network meta-analysis
- Discontinuation due to adverse eventsType 2 diabetes (adults); longest follow-up; descriptive only
- Discontinuation due to adverse eventsType 2 diabetes (adults); longest follow-up; network meta-analysis
- Discontinuation due to gastrointestinal adverse eventsType 2 diabetes (adults); longest follow-up; network meta-analysis
- Discontinuation due to gastrointestinal adverse eventsType 2 diabetes (adults); longest follow-up; descriptive only
Results
12 adjudicated result lines, grouped by outcome. Open an outcome to see its values.
HbA1c change (2 lines; O01)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| 24 | A1 | final | 5.67 percent | 0.71 | 48 | not stated; other; R0016372:Table 1 | |
| 24 | A2 | final | 6.74 percent | 0.82 | 48 | not stated; other; R0016372:Table 1 |
Level 2 or 3 hypoglycemia (participants) (2 lines; O04)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 1 / 48 | not stated; other; R0016372:Table 4 | ||||
| A2 | events | 2 / 48 | not stated; other; R0016372:Table 4 |
Discontinuation due to adverse events (2 lines; O26)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 0 / 48 | not stated; other; R0016372:Results | ||||
| A2 | events | 0 / 48 | not stated; other; R0016372:Results |
Nausea (2 lines; O27A)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 0 / 48 | not stated; other; nausea and vomiting; R0016372:Table 4 | ||||
| A2 | events | 2 / 48 | not stated; other; nausea and vomiting; R0016372:Table 4 |
Discontinuation due to gastrointestinal adverse events (2 lines; O27E)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 0 / 48 | not stated; other; R0016372:Results | ||||
| A2 | events | 0 / 48 | not stated; other; R0016372:Results |
Gallbladder and biliary disease (2 lines; O28)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 0 / 48 | not stated; other; cholecystitis; R0016372:Table 4 | ||||
| A2 | events | 2 / 48 | not stated; other; cholecystitis; R0016372:Table 4 |