parallel randomized trial

S002970

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

Overweight or obesity without diabetes (adults)S002970

Design

Randomized: 39
Start year: 2019
Treatment: 26.07 weeks, follow-up 26.07 weeks
Countries: China (1 sites)
Sponsor: (non industry)
Eligibility: age 20 to 75; BMI 27 to 40; impaired glucose tolerance by OGTT; no diabetes

Conduct and analysis

Blinding: double blind
Sequence generation: not reported
Allocation concealment: not reported
Outcome adjudication: not reported
Primary estimand: not stated
Analysis population
Missing data

Arms

Arm	Treatment	Background	Randomized	Analyzed	Completed treatment
A1	Lifestyle intervention (randomized arm) Lifestyle intervention	lifestyle: standard	22	22
A2	Liraglutide 1.2 mg subcutaneous once daily Liraglutide	lifestyle: not reported	17	17

Baseline characteristics

As printed in the trial reports or registry, per arm or for the whole trial.

Characteristic	Statistic	Lifestyle intervention (randomized arm) A1	Liraglutide 1.2 mg subcutaneous once daily A2
age	mean (years)	48.91	44.92
age	sd (years)	10.12	14.69
bmi	mean (kg/m2)	26.21	26.84
bmi	sd (kg/m2)	4.33	2.47
female	n	15	11
female	percent	68.18	64.71
hba1c	mean (percent)	5.91	5.98
hba1c	sd (percent)	0.33	0.42
sbp	mean (mmHg)	69.47	67.33
sbp	sd (mmHg)	11.13	10.57
waist	mean (cm)	87.12	86.52
waist	sd (cm)	5.74	4.98

Analyses this trial contributes to

Results

12 adjudicated result lines, grouped by outcome. Open an outcome to see its values.

Systolic blood pressure change (4 lines; O05)

Week	Arm	Statistic	Estimate	SE or SD	Events / N	Detail
26.07	A1	change	-0.25 mmHg		22	not stated; other; R0008860:Table I
26.07	A1	final	69.22 mmHg	11.64	22	not stated; other; R0008860:Table I
26.07	A2	change	-0.31 mmHg		17	not stated; other; R0008860:Table I
26.07	A2	final	67.02 mmHg	11.16	17	not stated; other; R0008860:Table I

Nausea (2 lines; O27A)

Week	Arm	Statistic	Estimate	SE or SD	95% CI	Events / N	Detail
	A1	events				1 / 22	not stated; randomized; R0008860:Supplementary Table SI
	A2	events				4 / 17	not stated; randomized; R0008860:Supplementary Table SI

Vomiting (2 lines; O27B)

Week	Arm	Statistic	Estimate	SE or SD	95% CI	Events / N	Detail
	A1	events				0 / 22	not stated; randomized; R0008860:Supplementary Table SI
	A2	events				0 / 17	not stated; randomized; R0008860:Supplementary Table SI

Diarrhea (2 lines; O27C)

Week	Arm	Statistic	Estimate	SE or SD	95% CI	Events / N	Detail
	A1	events				1 / 22	not stated; randomized; R0008860:Supplementary Table SI
	A2	events				2 / 17	not stated; randomized; R0008860:Supplementary Table SI

Constipation (2 lines; O27D)

Week	Arm	Statistic	Estimate	SE or SD	95% CI	Events / N	Detail
	A1	events				0 / 22	not stated; randomized; R0008860:Supplementary Table SI
	A2	events				0 / 17	not stated; randomized; R0008860:Supplementary Table SI