Network meta-analysis

HbA1c change

Type 2 diabetes (adults); background therapy: one or more non insulin glucose lowering drugs

weeks 20 to 36 (target week 26)Not stated by the trialsEach dose separatelyMean difference

Randomized trials

Treatments

20,514

Participants

140

Trial arms

In plain language

Across 58 trials with 20,514 participants, 38 of 43 treatments had a clearly better result than placebo on HbA1c change, 1 a clearly worse one, and for 4 the evidence could not tell them apart from placebo. The most favorable estimate was for Semaglutide 1.0 mg subcutaneous once weekly: mean difference -1.64 percentage points (95% credible interval -1.90 to -1.39).

Lower values favor the treatment. "Clearly" means the 95% credible interval excludes no difference. These are averages across trials; they do not say how any one person will respond. Not medical advice.

Network of trials

Each circle is a treatment; each line joins treatments that were randomized against each other in at least one trial.

Node area shows participants; line width shows trials comparing two treatments directly. Blue: GLP-1 receptor agonist containing treatments; grey: comparators. Hover over or tab to a node or line for details.

Effects compared with Placebo

Mean difference in percentage points. Lower values favor the treatment.

Versus Placebo. Blue: Bayesian random effects posterior median with 95% credible interval (thick) and 95% prediction interval (dashed). Amber diamond: frequentist estimate with 95% confidence interval. Hover over or tab to a row for its values.

Effects of each treatment versus Placebo
Treatment	Bayesian MD (95% CrI)	95% prediction interval	Frequentist MD (95% CI)	Verdict
Semaglutide 1.0 mg subcutaneous once weekly SEMA_SC_1p0MG_QW	-1.64 (-1.90 to -1.39)	-2.18 to -1.13	-1.65 (-1.90 to -1.40)	Better
Liraglutide and empagliflozin 1.8 to 25 mg injection once daily EMPALIRA_SC_1p8-25MG_QD	-1.62 (-2.18 to -1.04)	-2.34 to -0.86	-1.69 (-2.27 to -1.12)	Better
Exenatide extended release and dapagliflozin 2 to 10 mg injection once weekly DAPAEXEN_SC_2-10MG_QW	-1.45 (-1.99 to -0.89)	-2.15 to -0.75	-1.50 (-2.04 to -0.95)	Better
Exenatide and rosiglitazone 10 to 4 µg injection twice daily EXENROSI_SC_10-4UG_BID	-1.21 (-1.77 to -0.64)	-1.92 to -0.51	-1.26 (-1.81 to -0.71)	Better
Insulin degludec and liraglutide (IDegLira) subcutaneous once daily titrated IDEGLIRA_SC_TIT_QD	-1.20 (-1.46 to -0.94)	-1.73 to -0.67	-1.23 (-1.48 to -0.97)	Better
Semaglutide 0.5 mg subcutaneous once weekly SEMA_SC_0p5MG_QW	-1.19 (-1.62 to -0.75)	-1.82 to -0.56	-1.21 (-1.64 to -0.78)	Better
Dulaglutide 1.5 mg subcutaneous once weekly DULA_SC_1p5MG_QW	-1.15 (-1.44 to -0.85)	-1.67 to -0.62	-1.18 (-1.46 to -0.89)	Better
Basal insulin OTHER_ACTIVE_basal_insulin	-1.12 (-1.71 to -0.50)	-1.85 to -0.34	-1.19 (-1.79 to -0.59)	Better
Taspoglutide 20 mg subcutaneous once weekly TASP_SC_20MG_QW	-1.11 (-1.45 to -0.78)	-1.66 to -0.57	-1.14 (-1.47 to -0.81)	Better
IGlarLixi 2:1 pen subcutaneous once daily titrated IGLARLIXI2_SC_TIT_QD	-1.10 (-1.55 to -0.64)	-1.72 to -0.46	-1.13 (-1.57 to -0.69)	Better
Exenatide extended release 2 mg subcutaneous once weekly EXENER_SC_2MG_QW	-1.09 (-1.31 to -0.86)	-1.59 to -0.58	-1.12 (-1.34 to -0.89)	Better
Glimepiride GLIMEPIRIDE	-1.07 (-1.49 to -0.63)	-1.68 to -0.45	-1.09 (-1.52 to -0.67)	Better
Liraglutide 1.8 mg subcutaneous once daily LIRA_SC_1p8MG_QD	-1.06 (-1.25 to -0.86)	-1.54 to -0.58	-1.09 (-1.28 to -0.90)	Better
Liraglutide 1.2 mg subcutaneous once daily LIRA_SC_1p2MG_QD	-1.06 (-1.31 to -0.80)	-1.56 to -0.54	-1.07 (-1.31 to -0.83)	Better
Taspoglutide 10 mg subcutaneous once weekly TASP_SC_10MG_QW	-1.04 (-1.37 to -0.71)	-1.60 to -0.49	-1.07 (-1.40 to -0.74)	Better
Polyethylene glycol loxenatide 0.2 mg subcutaneous once weekly PEGLOX_SC_0p2MG_QW	-0.98 (-1.61 to -0.35)	-1.74 to -0.20	-1.02 (-1.65 to -0.39)	Better
Beinaglutide flexible dose injection three times daily BEIN_SC_FLEX_0p1-0p2_TID	-0.98 (-2.08 to 0.17)	-2.14 to 0.28	-1.13 (-2.28 to 0.03)	Unclear
Empagliflozin EMPAGLIFLOZIN	-0.93 (-1.52 to -0.30)	-1.66 to -0.17	-0.99 (-1.59 to -0.39)	Better
Rosiglitazone ROSIGLITAZONE	-0.92 (-1.48 to -0.35)	-1.62 to -0.18	-0.96 (-1.51 to -0.41)	Better
Dulaglutide 0.75 mg subcutaneous once weekly DULA_SC_0p75MG_QW	-0.90 (-1.23 to -0.56)	-1.44 to -0.35	-0.92 (-1.25 to -0.59)	Better
Liraglutide 0.9 mg injection once daily LIRA_SC_0p9MG_QD	-0.89 (-1.29 to -0.49)	-1.48 to -0.27	-0.91 (-1.30 to -0.53)	Better
Insulin degludec INS_DEGLUDEC	-0.89 (-1.33 to -0.41)	-1.52 to -0.24	-0.91 (-1.36 to -0.46)	Better
Standard care or no added treatment STANDARD_CARE	-0.84 (-1.59 to -0.08)	-1.72 to 0.03	-0.88 (-1.63 to -0.12)	Better
Polyethylene glycol loxenatide 400 µg injection once weekly PEGLOX_SC_400UG_QW	-0.83 (-1.32 to -0.34)	-1.49 to -0.16	-0.84 (-1.31 to -0.37)	Better
Exenatide 10 ug subcutaneous twice daily EXEN_SC_10UG_BID	-0.83 (-1.04 to -0.62)	-1.32 to -0.34	-0.86 (-1.07 to -0.66)	Better
Pioglitazone PIOGLITAZONE	-0.83 (-1.32 to -0.33)	-1.49 to -0.16	-0.86 (-1.34 to -0.38)	Better
Cotadutide 200 ug subcutaneous once daily COTA_SC_200UG_QD	-0.80 (-1.30 to -0.30)	-1.46 to -0.13	-0.82 (-1.30 to -0.34)	Better
Insulin glargine INS_GLARGINE	-0.79 (-0.98 to -0.59)	-1.29 to -0.30	-0.82 (-1.01 to -0.63)	Better
Liraglutide 0.6 mg subcutaneous once daily LIRA_SC_0p6MG_QD	-0.79 (-1.12 to -0.46)	-1.33 to -0.23	-0.81 (-1.13 to -0.48)	Better
Semaglutide 7 mg oral once daily (original tablet) SEMA_PO_7MG_QD	-0.78 (-1.27 to -0.27)	-1.43 to -0.09	-0.82 (-1.32 to -0.31)	Better
Exenatide 5 ug subcutaneous twice daily EXEN_SC_5UG_BID	-0.77 (-1.26 to -0.28)	-1.44 to -0.14	-0.80 (-1.28 to -0.31)	Better
Premixed insulin INS_PREMIX	-0.76 (-1.17 to -0.32)	-1.36 to -0.15	-0.82 (-1.23 to -0.40)	Better
Cotadutide 300 ug subcutaneous once daily COTA_SC_300UG_QD	-0.70 (-1.18 to -0.19)	-1.37 to -0.02	-0.72 (-1.20 to -0.24)	Better
Liraglutide flexible dose injection once daily LIRA_SC_FLEX_1p2-1p8_QD	-0.69 (-1.21 to -0.17)	-1.37 to 0.00	-0.72 (-1.22 to -0.21)	Better
Insulin detemir INS_DETEMIR	-0.67 (-1.19 to -0.10)	-1.35 to 0.05	-0.70 (-1.23 to -0.17)	Better
Cotadutide 100 ug subcutaneous once daily COTA_SC_100UG_QD	-0.64 (-1.17 to -0.12)	-1.32 to 0.05	-0.66 (-1.16 to -0.16)	Better
Sitagliptin SITAGLIPTIN	-0.59 (-0.81 to -0.37)	-1.08 to -0.08	-0.62 (-0.84 to -0.39)	Better
Polyethylene glycol loxenatide 300 µg injection once weekly PEGLOX_SC_300UG_QW	-0.51 (-1.00 to -0.01)	-1.17 to 0.18	-0.52 (-0.99 to -0.05)	Better
Sulfonylurea OTHER_ACTIVE_sulfonylurea	-0.46 (-0.99 to 0.07)	-1.13 to 0.24	-0.49 (-1.01 to 0.03)	Unclear
Lixisenatide 20 ug subcutaneous once daily LIXI_SC_20UG_QD	-0.42 (-0.75 to -0.07)	-0.97 to 0.16	-0.44 (-0.77 to -0.10)	Better
Testosterone OTHER_ACTIVE_testosterone	-0.34 (-1.10 to 0.41)	-1.22 to 0.51	-0.35 (-1.12 to 0.42)	Unclear
Dpp4 inhibitor OTHER_ACTIVE_dpp4_inhibitor	-0.28 (-0.99 to 0.45)	-1.13 to 0.57	-0.32 (-1.03 to 0.40)	Unclear
Dapagliflozin DAPAGLIFLOZIN	5.70 (3.91 to 7.44)	3.89 to 7.51	6.55 (4.64 to 8.47)	Worse

Ranking

How likely each treatment is to be among the best. Rankings ignore the size of differences and their certainty, so read them with the effects above.

League table

Every treatment against every other: mean difference of the row treatment versus the column treatment, posterior median and 95% credible interval. Green: row clearly better; red: row clearly worse.

Every treatment in a row compared with every treatment in a column
Row versus column	PLACEBO	SEMA_SC_1p0MG_QW	EMPALIRA_SC_1p8-25MG_QD	DAPAEXEN_SC_2-10MG_QW	EXENROSI_SC_10-4UG_BID	IDEGLIRA_SC_TIT_QD	SEMA_SC_0p5MG_QW	DULA_SC_1p5MG_QW	OTHER_ACTIVE_basal_insulin	TASP_SC_20MG_QW	IGLARLIXI2_SC_TIT_QD	EXENER_SC_2MG_QW	GLIMEPIRIDE	LIRA_SC_1p8MG_QD	LIRA_SC_1p2MG_QD	TASP_SC_10MG_QW	PEGLOX_SC_0p2MG_QW	BEIN_SC_FLEX_0p1-0p2_TID	EMPAGLIFLOZIN	ROSIGLITAZONE	DULA_SC_0p75MG_QW	LIRA_SC_0p9MG_QD	INS_DEGLUDEC	STANDARD_CARE	PEGLOX_SC_400UG_QW	EXEN_SC_10UG_BID	PIOGLITAZONE	COTA_SC_200UG_QD	INS_GLARGINE	LIRA_SC_0p6MG_QD	SEMA_PO_7MG_QD	EXEN_SC_5UG_BID	INS_PREMIX	COTA_SC_300UG_QD	LIRA_SC_FLEX_1p2-1p8_QD	INS_DETEMIR	COTA_SC_100UG_QD	SITAGLIPTIN	PEGLOX_SC_300UG_QW	OTHER_ACTIVE_sulfonylurea	LIXI_SC_20UG_QD	OTHER_ACTIVE_testosterone	OTHER_ACTIVE_dpp4_inhibitor	DAPAGLIFLOZIN
PLACEBO	PLACEBO	1.64 1.39 to 1.90	1.62 1.04 to 2.18	1.45 0.89 to 1.99	1.21 0.64 to 1.77	1.20 0.94 to 1.46	1.19 0.75 to 1.62	1.15 0.85 to 1.44	1.12 0.50 to 1.71	1.11 0.78 to 1.45	1.10 0.64 to 1.55	1.09 0.86 to 1.31	1.07 0.63 to 1.49	1.06 0.86 to 1.25	1.06 0.80 to 1.31	1.04 0.71 to 1.37	0.98 0.35 to 1.61	0.98 -0.17 to 2.08	0.93 0.30 to 1.52	0.92 0.35 to 1.48	0.90 0.56 to 1.23	0.89 0.49 to 1.29	0.89 0.41 to 1.33	0.84 0.08 to 1.59	0.83 0.34 to 1.32	0.83 0.62 to 1.04	0.83 0.33 to 1.32	0.80 0.30 to 1.30	0.79 0.59 to 0.98	0.79 0.46 to 1.12	0.78 0.27 to 1.27	0.77 0.28 to 1.26	0.76 0.32 to 1.17	0.70 0.19 to 1.18	0.69 0.17 to 1.21	0.67 0.10 to 1.19	0.64 0.12 to 1.17	0.59 0.37 to 0.81	0.51 0.01 to 1.00	0.46 -0.07 to 0.99	0.42 0.07 to 0.75	0.34 -0.41 to 1.10	0.28 -0.45 to 0.99	-5.70 -7.44 to -3.91
SEMA_SC_1p0MG_QW	-1.64 -1.90 to -1.39	SEMA_SC_1p0MG_QW	-0.03 -0.67 to 0.58	-0.19 -0.79 to 0.40	-0.43 -1.04 to 0.18	-0.44 -0.79 to -0.10	-0.46 -0.88 to -0.04	-0.49 -0.88 to -0.12	-0.52 -1.19 to 0.11	-0.53 -0.95 to -0.12	-0.54 -1.05 to -0.05	-0.56 -0.88 to -0.25	-0.57 -1.07 to -0.10	-0.58 -0.88 to -0.29	-0.59 -0.90 to -0.29	-0.60 -1.01 to -0.20	-0.66 -1.35 to -0.02	-0.67 -1.84 to 0.45	-0.72 -1.38 to -0.09	-0.73 -1.34 to -0.12	-0.75 -1.15 to -0.34	-0.75 -1.22 to -0.30	-0.76 -1.27 to -0.26	-0.80 -1.60 to -0.01	-0.82 -1.36 to -0.27	-0.82 -1.12 to -0.50	-0.82 -1.36 to -0.29	-0.84 -1.43 to -0.28	-0.85 -1.15 to -0.58	-0.86 -1.26 to -0.46	-0.87 -1.43 to -0.32	-0.87 -1.41 to -0.34	-0.88 -1.39 to -0.41	-0.94 -1.52 to -0.38	-0.96 -1.53 to -0.39	-0.98 -1.58 to -0.42	-1.00 -1.60 to -0.42	-1.06 -1.37 to -0.74	-1.13 -1.69 to -0.58	-1.18 -1.76 to -0.63	-1.23 -1.65 to -0.82	-1.30 -2.02 to -0.58	-1.37 -2.12 to -0.62	-7.34 -9.07 to -5.58
EMPALIRA_SC_1p8-25MG_QD	-1.62 -2.18 to -1.04	0.03 -0.58 to 0.67	EMPALIRA_SC_1p8-25MG_QD	-0.16 -0.94 to 0.60	-0.41 -1.16 to 0.38	-0.42 -1.01 to 0.19	-0.43 -1.11 to 0.29	-0.47 -1.07 to 0.15	-0.50 -1.06 to 0.06	-0.51 -1.14 to 0.15	-0.52 -1.24 to 0.21	-0.53 -1.10 to 0.05	-0.56 -1.24 to 0.18	-0.56 -1.08 to -0.02	-0.57 -1.16 to 0.05	-0.58 -1.22 to 0.07	-0.64 -1.46 to 0.19	-0.64 -1.90 to 0.58	-0.70 -1.25 to -0.13	-0.70 -1.47 to 0.10	-0.72 -1.35 to -0.06	-0.73 -1.40 to -0.04	-0.74 -1.42 to -0.02	-0.77 -1.72 to 0.14	-0.79 -1.53 to -0.03	-0.79 -1.36 to -0.20	-0.79 -1.50 to -0.06	-0.82 -1.57 to -0.06	-0.83 -1.39 to -0.25	-0.83 -1.48 to -0.18	-0.84 -1.57 to -0.09	-0.85 -1.58 to -0.10	-0.86 -1.55 to -0.16	-0.91 -1.66 to -0.15	-0.94 -1.65 to -0.18	-0.95 -1.72 to -0.19	-0.98 -1.72 to -0.20	-1.03 -1.59 to -0.45	-1.10 -1.84 to -0.35	-1.16 -1.85 to -0.42	-1.20 -1.85 to -0.53	-1.28 -2.21 to -0.34	-1.35 -2.21 to -0.44	-7.31 -9.14 to -5.43
DAPAEXEN_SC_2-10MG_QW	-1.45 -1.99 to -0.89	0.19 -0.40 to 0.79	0.16 -0.60 to 0.94	DAPAEXEN_SC_2-10MG_QW	-0.24 -1.00 to 0.51	-0.25 -0.82 to 0.34	-0.27 -0.94 to 0.42	-0.30 -0.91 to 0.31	-0.33 -1.14 to 0.46	-0.34 -0.96 to 0.27	-0.35 -1.04 to 0.35	-0.37 -0.86 to 0.15	-0.39 -1.05 to 0.31	-0.39 -0.94 to 0.17	-0.40 -0.98 to 0.19	-0.41 -1.02 to 0.21	-0.48 -1.29 to 0.34	-0.47 -1.71 to 0.71	-0.53 -1.33 to 0.28	-0.54 -1.30 to 0.24	-0.55 -1.16 to 0.09	-0.56 -1.24 to 0.11	-0.57 -1.25 to 0.13	-0.61 -1.52 to 0.29	-0.63 -1.35 to 0.10	-0.62 -1.17 to -0.07	-0.62 -1.30 to 0.07	-0.65 -1.38 to 0.08	-0.66 -1.20 to -0.10	-0.66 -1.29 to -0.02	-0.67 -1.38 to 0.02	-0.68 -1.40 to 0.04	-0.69 -1.38 to -0.03	-0.76 -1.49 to -0.01	-0.77 -1.49 to -0.02	-0.79 -1.49 to -0.11	-0.82 -1.56 to -0.06	-0.86 -1.41 to -0.29	-0.94 -1.67 to -0.20	-0.99 -1.72 to -0.27	-1.04 -1.65 to -0.39	-1.11 -2.03 to -0.17	-1.18 -2.04 to -0.31	-7.15 -8.96 to -5.27
EXENROSI_SC_10-4UG_BID	-1.21 -1.77 to -0.64	0.43 -0.18 to 1.04	0.41 -0.38 to 1.16	0.24 -0.51 to 1.00	EXENROSI_SC_10-4UG_BID	-0.01 -0.61 to 0.59	-0.03 -0.72 to 0.67	-0.07 -0.67 to 0.57	-0.09 -0.89 to 0.69	-0.11 -0.71 to 0.52	-0.11 -0.82 to 0.61	-0.13 -0.70 to 0.44	-0.14 -0.84 to 0.56	-0.15 -0.72 to 0.42	-0.16 -0.76 to 0.45	-0.17 -0.78 to 0.44	-0.23 -1.08 to 0.60	-0.24 -1.46 to 0.95	-0.28 -1.10 to 0.48	-0.29 -0.82 to 0.23	-0.31 -0.94 to 0.33	-0.32 -1.01 to 0.35	-0.33 -1.03 to 0.39	-0.37 -1.28 to 0.55	-0.39 -1.11 to 0.36	-0.38 -0.89 to 0.14	-0.39 -1.10 to 0.33	-0.41 -1.15 to 0.34	-0.42 -0.99 to 0.15	-0.42 -1.06 to 0.23	-0.43 -1.17 to 0.30	-0.45 -1.14 to 0.28	-0.45 -1.09 to 0.17	-0.51 -1.26 to 0.24	-0.52 -1.24 to 0.21	-0.55 -1.31 to 0.18	-0.57 -1.33 to 0.19	-0.63 -1.21 to -0.04	-0.70 -1.44 to 0.03	-0.75 -1.49 to 0.01	-0.80 -1.42 to -0.14	-0.87 -1.81 to 0.06	-0.93 -1.84 to -0.04	-6.91 -8.76 to -5.08
IDEGLIRA_SC_TIT_QD	-1.20 -1.46 to -0.94	0.44 0.10 to 0.79	0.42 -0.19 to 1.01	0.25 -0.34 to 0.82	0.01 -0.59 to 0.61	IDEGLIRA_SC_TIT_QD	-0.01 -0.49 to 0.46	-0.05 -0.41 to 0.32	-0.09 -0.74 to 0.55	-0.09 -0.50 to 0.31	-0.10 -0.60 to 0.39	-0.12 -0.42 to 0.19	-0.13 -0.63 to 0.35	-0.14 -0.40 to 0.13	-0.14 -0.49 to 0.20	-0.16 -0.56 to 0.23	-0.22 -0.88 to 0.43	-0.22 -1.39 to 0.91	-0.28 -0.93 to 0.36	-0.29 -0.90 to 0.31	-0.30 -0.70 to 0.09	-0.31 -0.77 to 0.14	-0.32 -0.76 to 0.12	-0.36 -1.14 to 0.43	-0.37 -0.92 to 0.19	-0.37 -0.67 to -0.07	-0.37 -0.90 to 0.16	-0.40 -0.97 to 0.16	-0.41 -0.66 to -0.16	-0.41 -0.81 to -0.01	-0.42 -0.98 to 0.12	-0.43 -0.97 to 0.12	-0.44 -0.94 to 0.03	-0.50 -1.07 to 0.07	-0.52 -1.06 to 0.05	-0.54 -1.13 to 0.03	-0.56 -1.14 to 0.04	-0.61 -0.92 to -0.30	-0.70 -1.25 to -0.13	-0.74 -1.31 to -0.18	-0.79 -1.18 to -0.37	-0.86 -1.64 to -0.06	-0.92 -1.68 to -0.17	-6.90 -8.66 to -5.12
SEMA_SC_0p5MG_QW	-1.19 -1.62 to -0.75	0.46 0.04 to 0.88	0.43 -0.29 to 1.11	0.27 -0.42 to 0.94	0.03 -0.67 to 0.72	0.01 -0.46 to 0.49	SEMA_SC_0p5MG_QW	-0.04 -0.54 to 0.46	-0.07 -0.78 to 0.65	-0.07 -0.62 to 0.45	-0.08 -0.70 to 0.51	-0.10 -0.57 to 0.36	-0.11 -0.73 to 0.49	-0.12 -0.58 to 0.33	-0.13 -0.61 to 0.35	-0.15 -0.68 to 0.39	-0.21 -0.96 to 0.54	-0.21 -1.44 to 0.96	-0.26 -1.01 to 0.46	-0.27 -0.96 to 0.42	-0.28 -0.81 to 0.25	-0.29 -0.87 to 0.26	-0.30 -0.92 to 0.29	-0.35 -1.21 to 0.51	-0.36 -1.00 to 0.30	-0.36 -0.82 to 0.11	-0.36 -1.00 to 0.28	-0.38 -1.06 to 0.26	-0.39 -0.81 to 0.02	-0.40 -0.94 to 0.14	-0.41 -1.05 to 0.24	-0.42 -1.06 to 0.24	-0.42 -1.03 to 0.16	-0.49 -1.16 to 0.18	-0.50 -1.17 to 0.18	-0.52 -1.20 to 0.14	-0.54 -1.24 to 0.14	-0.60 -1.06 to -0.12	-0.68 -1.31 to -0.01	-0.72 -1.40 to -0.06	-0.77 -1.30 to -0.23	-0.84 -1.69 to -0.01	-0.91 -1.73 to -0.06	-6.87 -8.67 to -5.05
DULA_SC_1p5MG_QW	-1.15 -1.44 to -0.85	0.49 0.12 to 0.88	0.47 -0.15 to 1.07	0.30 -0.31 to 0.91	0.07 -0.57 to 0.67	0.05 -0.32 to 0.41	0.04 -0.46 to 0.54	DULA_SC_1p5MG_QW	-0.03 -0.69 to 0.61	-0.04 -0.47 to 0.39	-0.05 -0.56 to 0.47	-0.06 -0.40 to 0.27	-0.08 -0.60 to 0.43	-0.09 -0.39 to 0.20	-0.09 -0.46 to 0.27	-0.11 -0.54 to 0.32	-0.18 -0.84 to 0.50	-0.17 -1.35 to 0.97	-0.22 -0.89 to 0.41	-0.23 -0.83 to 0.37	-0.25 -0.56 to 0.07	-0.25 -0.75 to 0.21	-0.26 -0.80 to 0.26	-0.31 -1.03 to 0.39	-0.32 -0.88 to 0.25	-0.32 -0.66 to 0.02	-0.33 -0.87 to 0.22	-0.35 -0.93 to 0.23	-0.36 -0.66 to -0.06	-0.36 -0.78 to 0.07	-0.37 -0.95 to 0.19	-0.38 -0.95 to 0.20	-0.39 -0.89 to 0.10	-0.45 -1.03 to 0.14	-0.46 -1.05 to 0.12	-0.49 -1.10 to 0.11	-0.51 -1.12 to 0.11	-0.56 -0.90 to -0.22	-0.64 -1.20 to -0.07	-0.69 -1.25 to -0.12	-0.73 -1.15 to -0.30	-0.80 -1.61 to 0.01	-0.87 -1.64 to -0.11	-6.84 -8.60 to -5.06
OTHER_ACTIVE_basal_insulin	-1.12 -1.71 to -0.50	0.52 -0.11 to 1.19	0.50 -0.06 to 1.06	0.33 -0.46 to 1.14	0.09 -0.69 to 0.89	0.09 -0.55 to 0.74	0.07 -0.65 to 0.78	0.03 -0.61 to 0.69	OTHER_ACTIVE_basal_insulin	-0.01 -0.68 to 0.66	-0.02 -0.75 to 0.73	-0.03 -0.65 to 0.60	-0.05 -0.77 to 0.69	-0.06 -0.62 to 0.52	-0.07 -0.69 to 0.58	-0.08 -0.75 to 0.61	-0.15 -0.98 to 0.73	-0.13 -1.44 to 1.10	-0.19 -0.79 to 0.38	-0.21 -1.00 to 0.62	-0.22 -0.89 to 0.47	-0.22 -0.92 to 0.48	-0.24 -0.96 to 0.49	-0.28 -1.22 to 0.67	-0.29 -1.06 to 0.50	-0.29 -0.89 to 0.34	-0.29 -1.05 to 0.47	-0.32 -1.08 to 0.46	-0.32 -0.93 to 0.29	-0.33 -0.99 to 0.36	-0.34 -1.10 to 0.42	-0.36 -1.11 to 0.44	-0.36 -1.05 to 0.36	-0.42 -1.18 to 0.36	-0.44 -1.20 to 0.35	-0.46 -1.24 to 0.32	-0.48 -1.26 to 0.33	-0.53 -1.13 to 0.08	-0.61 -1.38 to 0.18	-0.66 -1.41 to 0.11	-0.71 -1.38 to 0.00	-0.77 -1.73 to 0.20	-0.85 -1.77 to 0.06	-6.81 -8.68 to -4.94
TASP_SC_20MG_QW	-1.11 -1.45 to -0.78	0.53 0.12 to 0.95	0.51 -0.15 to 1.14	0.34 -0.27 to 0.96	0.11 -0.52 to 0.71	0.09 -0.31 to 0.50	0.07 -0.45 to 0.62	0.04 -0.39 to 0.47	0.01 -0.66 to 0.68	TASP_SC_20MG_QW	-0.01 -0.55 to 0.52	-0.02 -0.39 to 0.34	-0.04 -0.58 to 0.50	-0.04 -0.41 to 0.30	-0.06 -0.45 to 0.33	-0.07 -0.41 to 0.28	-0.13 -0.85 to 0.58	-0.13 -1.33 to 1.00	-0.19 -0.87 to 0.47	-0.19 -0.82 to 0.41	-0.21 -0.67 to 0.25	-0.22 -0.73 to 0.30	-0.23 -0.78 to 0.32	-0.26 -1.10 to 0.54	-0.28 -0.88 to 0.32	-0.28 -0.62 to 0.06	-0.28 -0.85 to 0.28	-0.31 -0.92 to 0.28	-0.32 -0.69 to 0.04	-0.32 -0.78 to 0.14	-0.33 -0.91 to 0.21	-0.34 -0.91 to 0.24	-0.35 -0.87 to 0.14	-0.41 -1.01 to 0.17	-0.43 -1.00 to 0.18	-0.45 -1.08 to 0.14	-0.47 -1.09 to 0.14	-0.52 -0.87 to -0.18	-0.60 -1.20 to -0.01	-0.65 -1.27 to -0.04	-0.69 -1.16 to -0.22	-0.77 -1.58 to 0.06	-0.83 -1.60 to -0.09	-6.80 -8.58 to -4.98
IGLARLIXI2_SC_TIT_QD	-1.10 -1.55 to -0.64	0.54 0.05 to 1.05	0.52 -0.21 to 1.24	0.35 -0.35 to 1.04	0.11 -0.61 to 0.82	0.10 -0.39 to 0.60	0.08 -0.51 to 0.70	0.05 -0.47 to 0.56	0.02 -0.73 to 0.75	0.01 -0.52 to 0.55	IGLARLIXI2_SC_TIT_QD	-0.01 -0.49 to 0.46	-0.03 -0.64 to 0.57	-0.03 -0.51 to 0.42	-0.05 -0.55 to 0.46	-0.06 -0.60 to 0.48	-0.12 -0.88 to 0.61	-0.12 -1.34 to 1.07	-0.17 -0.92 to 0.55	-0.19 -0.88 to 0.55	-0.20 -0.75 to 0.35	-0.20 -0.77 to 0.35	-0.22 -0.86 to 0.42	-0.26 -1.11 to 0.60	-0.27 -0.94 to 0.42	-0.27 -0.73 to 0.22	-0.28 -0.91 to 0.38	-0.31 -0.97 to 0.37	-0.31 -0.75 to 0.12	-0.31 -0.85 to 0.23	-0.32 -0.98 to 0.34	-0.33 -0.99 to 0.33	-0.34 -0.95 to 0.26	-0.40 -1.07 to 0.28	-0.42 -1.07 to 0.26	-0.44 -1.13 to 0.25	-0.46 -1.14 to 0.23	-0.51 -0.99 to -0.02	-0.59 -1.27 to 0.10	-0.64 -1.32 to 0.05	-0.68 -1.10 to -0.25	-0.76 -1.64 to 0.13	-0.82 -1.67 to 0.01	-6.80 -8.60 to -4.95
EXENER_SC_2MG_QW	-1.09 -1.31 to -0.86	0.56 0.25 to 0.88	0.53 -0.05 to 1.10	0.37 -0.15 to 0.86	0.13 -0.44 to 0.70	0.12 -0.19 to 0.42	0.10 -0.36 to 0.57	0.06 -0.27 to 0.40	0.03 -0.60 to 0.65	0.02 -0.34 to 0.39	0.01 -0.46 to 0.49	EXENER_SC_2MG_QW	-0.01 -0.49 to 0.46	-0.02 -0.25 to 0.20	-0.03 -0.33 to 0.28	-0.04 -0.41 to 0.33	-0.10 -0.75 to 0.52	-0.10 -1.26 to 1.02	-0.16 -0.77 to 0.44	-0.17 -0.73 to 0.40	-0.18 -0.56 to 0.18	-0.20 -0.63 to 0.24	-0.20 -0.68 to 0.28	-0.24 -1.02 to 0.51	-0.25 -0.78 to 0.29	-0.25 -0.48 to -0.03	-0.26 -0.73 to 0.21	-0.28 -0.83 to 0.26	-0.29 -0.51 to -0.08	-0.30 -0.68 to 0.08	-0.30 -0.83 to 0.20	-0.32 -0.82 to 0.20	-0.32 -0.76 to 0.09	-0.38 -0.94 to 0.16	-0.40 -0.92 to 0.13	-0.43 -0.93 to 0.06	-0.44 -1.01 to 0.13	-0.50 -0.74 to -0.25	-0.58 -1.11 to -0.02	-0.62 -1.16 to -0.09	-0.67 -1.05 to -0.27	-0.75 -1.52 to 0.03	-0.81 -1.53 to -0.10	-6.78 -8.52 to -4.97
GLIMEPIRIDE	-1.07 -1.49 to -0.63	0.57 0.10 to 1.07	0.56 -0.18 to 1.24	0.39 -0.31 to 1.05	0.14 -0.56 to 0.84	0.13 -0.35 to 0.63	0.11 -0.49 to 0.73	0.08 -0.43 to 0.60	0.05 -0.69 to 0.77	0.04 -0.50 to 0.58	0.03 -0.57 to 0.64	0.01 -0.46 to 0.49	GLIMEPIRIDE	-0.00 -0.45 to 0.43	-0.01 -0.46 to 0.44	-0.03 -0.56 to 0.49	-0.09 -0.85 to 0.68	-0.09 -1.30 to 1.08	-0.15 -0.86 to 0.56	-0.16 -0.86 to 0.56	-0.17 -0.69 to 0.37	-0.18 -0.75 to 0.40	-0.19 -0.81 to 0.43	-0.23 -1.10 to 0.62	-0.24 -0.89 to 0.41	-0.24 -0.70 to 0.22	-0.24 -0.87 to 0.39	-0.27 -0.93 to 0.40	-0.28 -0.73 to 0.18	-0.28 -0.76 to 0.21	-0.29 -0.95 to 0.35	-0.30 -0.94 to 0.36	-0.31 -0.91 to 0.27	-0.37 -1.03 to 0.31	-0.38 -1.03 to 0.29	-0.40 -1.09 to 0.26	-0.43 -1.11 to 0.25	-0.48 -0.94 to -0.02	-0.56 -1.20 to 0.10	-0.61 -1.29 to 0.06	-0.65 -1.18 to -0.10	-0.73 -1.59 to 0.14	-0.79 -1.62 to 0.03	-6.76 -8.56 to -4.92
LIRA_SC_1p8MG_QD	-1.06 -1.25 to -0.86	0.58 0.29 to 0.88	0.56 0.02 to 1.08	0.39 -0.17 to 0.94	0.15 -0.42 to 0.72	0.14 -0.13 to 0.40	0.12 -0.33 to 0.58	0.09 -0.20 to 0.39	0.06 -0.52 to 0.62	0.04 -0.30 to 0.41	0.03 -0.42 to 0.51	0.02 -0.20 to 0.25	0.00 -0.43 to 0.45	LIRA_SC_1p8MG_QD	-0.01 -0.27 to 0.26	-0.02 -0.37 to 0.34	-0.09 -0.72 to 0.55	-0.08 -1.22 to 1.01	-0.14 -0.71 to 0.43	-0.15 -0.71 to 0.42	-0.16 -0.50 to 0.19	-0.17 -0.59 to 0.24	-0.18 -0.62 to 0.27	-0.22 -0.98 to 0.53	-0.24 -0.74 to 0.29	-0.23 -0.45 to -0.00	-0.24 -0.72 to 0.27	-0.27 -0.79 to 0.28	-0.27 -0.48 to -0.06	-0.28 -0.62 to 0.07	-0.28 -0.78 to 0.20	-0.29 -0.80 to 0.23	-0.30 -0.74 to 0.12	-0.36 -0.90 to 0.19	-0.38 -0.87 to 0.15	-0.40 -0.95 to 0.13	-0.42 -0.97 to 0.14	-0.48 -0.67 to -0.26	-0.56 -1.08 to -0.02	-0.60 -1.09 to -0.11	-0.65 -1.01 to -0.26	-0.72 -1.50 to 0.06	-0.79 -1.50 to -0.07	-6.76 -8.50 to -4.97
LIRA_SC_1p2MG_QD	-1.06 -1.31 to -0.80	0.59 0.29 to 0.90	0.57 -0.05 to 1.16	0.40 -0.19 to 0.98	0.16 -0.45 to 0.76	0.14 -0.20 to 0.49	0.13 -0.35 to 0.61	0.09 -0.27 to 0.46	0.07 -0.58 to 0.69	0.06 -0.33 to 0.45	0.05 -0.46 to 0.55	0.03 -0.28 to 0.33	0.01 -0.44 to 0.46	0.01 -0.26 to 0.27	LIRA_SC_1p2MG_QD	-0.02 -0.41 to 0.38	-0.08 -0.75 to 0.58	-0.07 -1.26 to 1.05	-0.13 -0.79 to 0.49	-0.14 -0.74 to 0.47	-0.15 -0.56 to 0.25	-0.16 -0.62 to 0.29	-0.17 -0.68 to 0.32	-0.21 -1.01 to 0.56	-0.22 -0.76 to 0.33	-0.22 -0.52 to 0.07	-0.23 -0.75 to 0.29	-0.25 -0.82 to 0.30	-0.26 -0.56 to 0.02	-0.27 -0.63 to 0.10	-0.28 -0.82 to 0.25	-0.28 -0.84 to 0.27	-0.29 -0.78 to 0.17	-0.35 -0.93 to 0.19	-0.37 -0.92 to 0.19	-0.39 -0.98 to 0.17	-0.41 -0.99 to 0.16	-0.47 -0.75 to -0.18	-0.54 -1.10 to 0.00	-0.59 -1.15 to -0.04	-0.64 -1.05 to -0.22	-0.71 -1.51 to 0.06	-0.77 -1.53 to -0.05	-6.75 -8.50 to -4.93
TASP_SC_10MG_QW	-1.04 -1.37 to -0.71	0.60 0.20 to 1.01	0.58 -0.07 to 1.22	0.41 -0.21 to 1.02	0.17 -0.44 to 0.78	0.16 -0.23 to 0.56	0.15 -0.39 to 0.68	0.11 -0.32 to 0.54	0.08 -0.61 to 0.75	0.07 -0.28 to 0.41	0.06 -0.48 to 0.60	0.04 -0.33 to 0.41	0.03 -0.49 to 0.56	0.02 -0.34 to 0.37	0.02 -0.38 to 0.41	TASP_SC_10MG_QW	-0.06 -0.78 to 0.66	-0.06 -1.26 to 1.09	-0.12 -0.80 to 0.54	-0.12 -0.75 to 0.48	-0.14 -0.60 to 0.31	-0.15 -0.67 to 0.36	-0.16 -0.71 to 0.38	-0.20 -1.03 to 0.62	-0.21 -0.79 to 0.37	-0.21 -0.54 to 0.12	-0.21 -0.78 to 0.33	-0.24 -0.84 to 0.35	-0.25 -0.61 to 0.11	-0.25 -0.71 to 0.20	-0.25 -0.85 to 0.29	-0.27 -0.85 to 0.31	-0.28 -0.80 to 0.21	-0.34 -0.94 to 0.25	-0.36 -0.93 to 0.24	-0.37 -0.99 to 0.22	-0.40 -1.01 to 0.22	-0.45 -0.80 to -0.10	-0.53 -1.11 to 0.05	-0.58 -1.20 to 0.03	-0.62 -1.09 to -0.15	-0.69 -1.52 to 0.13	-0.76 -1.52 to -0.01	-6.72 -8.51 to -4.92
PEGLOX_SC_0p2MG_QW	-0.98 -1.61 to -0.35	0.66 0.02 to 1.35	0.64 -0.19 to 1.46	0.48 -0.34 to 1.29	0.23 -0.60 to 1.08	0.22 -0.43 to 0.88	0.21 -0.54 to 0.96	0.18 -0.50 to 0.84	0.15 -0.73 to 0.98	0.13 -0.58 to 0.85	0.12 -0.61 to 0.88	0.10 -0.52 to 0.75	0.09 -0.68 to 0.85	0.09 -0.55 to 0.72	0.08 -0.58 to 0.75	0.06 -0.66 to 0.78	PEGLOX_SC_0p2MG_QW	0.01 -1.30 to 1.26	-0.05 -0.90 to 0.78	-0.07 -0.89 to 0.77	-0.08 -0.75 to 0.61	-0.08 -0.82 to 0.64	-0.10 -0.85 to 0.67	-0.14 -1.11 to 0.83	-0.15 -0.95 to 0.68	-0.15 -0.78 to 0.50	-0.15 -0.91 to 0.62	-0.18 -0.98 to 0.64	-0.19 -0.79 to 0.42	-0.19 -0.87 to 0.52	-0.20 -0.97 to 0.60	-0.21 -0.98 to 0.61	-0.22 -0.97 to 0.52	-0.28 -1.08 to 0.53	-0.30 -1.07 to 0.52	-0.32 -1.12 to 0.49	-0.33 -1.16 to 0.48	-0.39 -1.04 to 0.27	-0.46 -1.27 to 0.33	-0.52 -1.29 to 0.28	-0.56 -1.25 to 0.16	-0.64 -1.60 to 0.34	-0.70 -1.65 to 0.27	-6.67 -8.53 to -4.77
BEIN_SC_FLEX_0p1-0p2_TID	-0.98 -2.08 to 0.17	0.67 -0.45 to 1.84	0.64 -0.58 to 1.90	0.47 -0.71 to 1.71	0.24 -0.95 to 1.46	0.22 -0.91 to 1.39	0.21 -0.96 to 1.44	0.17 -0.97 to 1.35	0.13 -1.10 to 1.44	0.13 -1.00 to 1.33	0.12 -1.07 to 1.34	0.10 -1.02 to 1.26	0.09 -1.08 to 1.30	0.08 -1.01 to 1.22	0.07 -1.05 to 1.26	0.06 -1.09 to 1.26	-0.01 -1.26 to 1.30	BEIN_SC_FLEX_0p1-0p2_TID	-0.06 -1.29 to 1.23	-0.06 -1.26 to 1.19	-0.08 -1.19 to 1.11	-0.09 -1.25 to 1.11	-0.10 -1.28 to 1.11	-0.13 -1.50 to 1.21	-0.15 -1.35 to 1.11	-0.15 -1.23 to 0.98	-0.16 -1.34 to 1.06	-0.18 -1.40 to 1.09	-0.19 -1.29 to 0.96	-0.19 -1.33 to 0.99	-0.19 -1.41 to 1.03	-0.21 -1.41 to 1.03	-0.22 -1.24 to 0.84	-0.28 -1.52 to 0.97	-0.30 -1.47 to 0.97	-0.32 -1.51 to 0.92	-0.34 -1.58 to 0.94	-0.39 -1.51 to 0.77	-0.46 -1.68 to 0.78	-0.52 -1.70 to 0.73	-0.56 -1.70 to 0.62	-0.64 -1.98 to 0.73	-0.70 -1.99 to 0.62	-6.68 -8.77 to -4.52
EMPAGLIFLOZIN	-0.93 -1.52 to -0.30	0.72 0.09 to 1.38	0.70 0.13 to 1.25	0.53 -0.28 to 1.33	0.28 -0.48 to 1.10	0.28 -0.36 to 0.93	0.26 -0.46 to 1.01	0.22 -0.41 to 0.89	0.19 -0.38 to 0.79	0.19 -0.47 to 0.87	0.17 -0.55 to 0.92	0.16 -0.44 to 0.77	0.15 -0.56 to 0.86	0.14 -0.43 to 0.71	0.13 -0.49 to 0.79	0.12 -0.54 to 0.80	0.05 -0.78 to 0.90	0.06 -1.23 to 1.29	EMPAGLIFLOZIN	-0.01 -0.78 to 0.82	-0.02 -0.67 to 0.65	-0.03 -0.72 to 0.69	-0.04 -0.75 to 0.70	-0.08 -1.02 to 0.87	-0.09 -0.85 to 0.70	-0.10 -0.69 to 0.54	-0.10 -0.83 to 0.66	-0.12 -0.90 to 0.65	-0.14 -0.73 to 0.48	-0.14 -0.79 to 0.55	-0.15 -0.88 to 0.63	-0.16 -0.91 to 0.61	-0.16 -0.85 to 0.55	-0.22 -1.01 to 0.56	-0.24 -1.00 to 0.54	-0.26 -1.04 to 0.53	-0.28 -1.08 to 0.51	-0.34 -0.93 to 0.28	-0.42 -1.17 to 0.36	-0.46 -1.19 to 0.30	-0.51 -1.17 to 0.21	-0.59 -1.53 to 0.37	-0.66 -1.55 to 0.27	-6.61 -8.47 to -4.77
ROSIGLITAZONE	-0.92 -1.48 to -0.35	0.73 0.12 to 1.34	0.70 -0.10 to 1.47	0.54 -0.24 to 1.30	0.29 -0.23 to 0.82	0.29 -0.31 to 0.90	0.27 -0.42 to 0.96	0.23 -0.37 to 0.83	0.21 -0.62 to 1.00	0.19 -0.41 to 0.82	0.19 -0.55 to 0.88	0.17 -0.40 to 0.73	0.16 -0.56 to 0.86	0.15 -0.42 to 0.71	0.14 -0.47 to 0.74	0.12 -0.48 to 0.75	0.07 -0.77 to 0.89	0.06 -1.19 to 1.26	0.01 -0.82 to 0.78	ROSIGLITAZONE	-0.01 -0.65 to 0.62	-0.02 -0.72 to 0.64	-0.03 -0.74 to 0.69	-0.08 -0.99 to 0.85	-0.09 -0.82 to 0.66	-0.09 -0.61 to 0.44	-0.08 -0.82 to 0.64	-0.12 -0.88 to 0.64	-0.12 -0.69 to 0.43	-0.12 -0.78 to 0.51	-0.14 -0.89 to 0.59	-0.15 -0.85 to 0.57	-0.15 -0.79 to 0.48	-0.22 -0.95 to 0.51	-0.23 -0.96 to 0.50	-0.25 -1.01 to 0.48	-0.27 -1.05 to 0.49	-0.33 -0.91 to 0.25	-0.41 -1.14 to 0.34	-0.45 -1.21 to 0.30	-0.50 -1.15 to 0.16	-0.57 -1.51 to 0.35	-0.64 -1.54 to 0.24	-6.61 -8.46 to -4.74
DULA_SC_0p75MG_QW	-0.90 -1.23 to -0.56	0.75 0.34 to 1.15	0.72 0.06 to 1.35	0.55 -0.09 to 1.16	0.31 -0.33 to 0.94	0.30 -0.09 to 0.70	0.28 -0.25 to 0.81	0.25 -0.07 to 0.56	0.22 -0.47 to 0.89	0.21 -0.25 to 0.67	0.20 -0.35 to 0.75	0.18 -0.18 to 0.56	0.17 -0.37 to 0.69	0.16 -0.19 to 0.50	0.15 -0.25 to 0.56	0.14 -0.31 to 0.60	0.08 -0.61 to 0.75	0.08 -1.11 to 1.19	0.02 -0.65 to 0.67	0.01 -0.62 to 0.65	DULA_SC_0p75MG_QW	-0.01 -0.53 to 0.49	-0.02 -0.58 to 0.52	-0.06 -0.83 to 0.72	-0.08 -0.66 to 0.51	-0.07 -0.43 to 0.29	-0.08 -0.65 to 0.50	-0.10 -0.72 to 0.50	-0.11 -0.44 to 0.23	-0.11 -0.57 to 0.35	-0.12 -0.72 to 0.47	-0.13 -0.71 to 0.46	-0.14 -0.66 to 0.36	-0.20 -0.81 to 0.40	-0.21 -0.80 to 0.39	-0.24 -0.87 to 0.37	-0.26 -0.88 to 0.37	-0.31 -0.69 to 0.07	-0.39 -0.98 to 0.21	-0.44 -1.03 to 0.16	-0.48 -0.94 to -0.01	-0.57 -1.38 to 0.26	-0.62 -1.41 to 0.14	-6.60 -8.36 to -4.79
LIRA_SC_0p9MG_QD	-0.89 -1.29 to -0.49	0.75 0.30 to 1.22	0.73 0.04 to 1.40	0.56 -0.11 to 1.24	0.32 -0.35 to 1.01	0.31 -0.14 to 0.77	0.29 -0.26 to 0.87	0.25 -0.21 to 0.75	0.22 -0.48 to 0.92	0.22 -0.30 to 0.73	0.20 -0.35 to 0.77	0.20 -0.24 to 0.63	0.18 -0.40 to 0.75	0.17 -0.24 to 0.59	0.16 -0.29 to 0.62	0.15 -0.36 to 0.67	0.08 -0.64 to 0.82	0.09 -1.11 to 1.25	0.03 -0.69 to 0.72	0.02 -0.64 to 0.72	0.01 -0.49 to 0.53	LIRA_SC_0p9MG_QD	-0.00 -0.60 to 0.58	-0.05 -0.88 to 0.82	-0.06 -0.70 to 0.59	-0.06 -0.49 to 0.37	-0.06 -0.67 to 0.56	-0.09 -0.72 to 0.55	-0.10 -0.51 to 0.31	-0.10 -0.53 to 0.34	-0.11 -0.73 to 0.50	-0.13 -0.74 to 0.51	-0.13 -0.71 to 0.43	-0.20 -0.82 to 0.46	-0.21 -0.84 to 0.44	-0.24 -0.89 to 0.43	-0.25 -0.90 to 0.45	-0.31 -0.73 to 0.13	-0.38 -1.01 to 0.26	-0.43 -1.08 to 0.21	-0.47 -0.98 to 0.06	-0.55 -1.42 to 0.31	-0.62 -1.43 to 0.19	-6.58 -8.36 to -4.76
INS_DEGLUDEC	-0.89 -1.33 to -0.41	0.76 0.26 to 1.27	0.74 0.02 to 1.42	0.57 -0.13 to 1.25	0.33 -0.39 to 1.03	0.32 -0.12 to 0.76	0.30 -0.29 to 0.92	0.26 -0.26 to 0.80	0.24 -0.49 to 0.96	0.23 -0.32 to 0.78	0.22 -0.42 to 0.86	0.20 -0.28 to 0.68	0.19 -0.43 to 0.81	0.18 -0.27 to 0.62	0.17 -0.32 to 0.68	0.16 -0.38 to 0.71	0.10 -0.67 to 0.85	0.10 -1.11 to 1.28	0.04 -0.70 to 0.75	0.03 -0.69 to 0.74	0.02 -0.52 to 0.58	0.00 -0.58 to 0.60	INS_DEGLUDEC	-0.04 -0.90 to 0.83	-0.05 -0.71 to 0.60	-0.06 -0.53 to 0.44	-0.06 -0.71 to 0.60	-0.08 -0.76 to 0.62	-0.09 -0.55 to 0.37	-0.09 -0.64 to 0.45	-0.11 -0.77 to 0.57	-0.11 -0.78 to 0.54	-0.12 -0.74 to 0.48	-0.18 -0.86 to 0.52	-0.20 -0.86 to 0.47	-0.22 -0.91 to 0.46	-0.25 -0.94 to 0.48	-0.29 -0.77 to 0.19	-0.38 -1.02 to 0.30	-0.42 -1.09 to 0.23	-0.46 -1.03 to 0.10	-0.54 -1.42 to 0.33	-0.61 -1.44 to 0.23	-6.57 -8.38 to -4.72
STANDARD_CARE	-0.84 -1.59 to -0.08	0.80 0.01 to 1.60	0.77 -0.14 to 1.72	0.61 -0.29 to 1.52	0.37 -0.55 to 1.28	0.36 -0.43 to 1.14	0.35 -0.51 to 1.21	0.31 -0.39 to 1.03	0.28 -0.67 to 1.22	0.26 -0.54 to 1.10	0.26 -0.60 to 1.11	0.24 -0.51 to 1.02	0.23 -0.62 to 1.10	0.22 -0.53 to 0.98	0.21 -0.56 to 1.01	0.20 -0.62 to 1.03	0.14 -0.83 to 1.11	0.13 -1.21 to 1.50	0.08 -0.87 to 1.02	0.08 -0.85 to 0.99	0.06 -0.72 to 0.83	0.05 -0.82 to 0.88	0.04 -0.83 to 0.90	STANDARD_CARE	-0.01 -0.91 to 0.89	-0.01 -0.77 to 0.76	-0.02 -0.88 to 0.86	-0.05 -0.93 to 0.86	-0.05 -0.79 to 0.71	-0.05 -0.88 to 0.77	-0.06 -0.94 to 0.85	-0.07 -0.99 to 0.83	-0.08 -0.96 to 0.78	-0.14 -1.03 to 0.76	-0.16 -1.06 to 0.76	-0.18 -1.11 to 0.72	-0.19 -1.11 to 0.69	-0.25 -1.02 to 0.52	-0.34 -1.22 to 0.57	-0.38 -1.28 to 0.51	-0.42 -1.25 to 0.39	-0.51 -1.55 to 0.58	-0.57 -1.59 to 0.47	-6.54 -8.45 to -4.59
PEGLOX_SC_400UG_QW	-0.83 -1.32 to -0.34	0.82 0.27 to 1.36	0.79 0.03 to 1.53	0.63 -0.10 to 1.35	0.39 -0.36 to 1.11	0.37 -0.19 to 0.92	0.36 -0.30 to 1.00	0.32 -0.25 to 0.88	0.29 -0.50 to 1.06	0.28 -0.32 to 0.88	0.27 -0.42 to 0.94	0.25 -0.29 to 0.78	0.24 -0.41 to 0.89	0.24 -0.29 to 0.74	0.22 -0.33 to 0.76	0.21 -0.37 to 0.79	0.15 -0.68 to 0.95	0.15 -1.11 to 1.35	0.09 -0.70 to 0.85	0.09 -0.66 to 0.82	0.08 -0.51 to 0.66	0.06 -0.59 to 0.70	0.05 -0.60 to 0.71	0.01 -0.89 to 0.91	PEGLOX_SC_400UG_QW	0.00 -0.53 to 0.53	-0.00 -0.71 to 0.70	-0.03 -0.74 to 0.67	-0.04 -0.57 to 0.48	-0.04 -0.64 to 0.54	-0.05 -0.76 to 0.64	-0.06 -0.74 to 0.63	-0.07 -0.73 to 0.56	-0.13 -0.85 to 0.57	-0.14 -0.88 to 0.57	-0.17 -0.91 to 0.54	-0.19 -0.90 to 0.55	-0.24 -0.78 to 0.29	-0.32 -0.83 to 0.18	-0.37 -1.10 to 0.34	-0.41 -1.01 to 0.18	-0.49 -1.39 to 0.41	-0.55 -1.42 to 0.30	-6.52 -8.33 to -4.65
EXEN_SC_10UG_BID	-0.83 -1.04 to -0.62	0.82 0.50 to 1.12	0.79 0.20 to 1.36	0.62 0.07 to 1.17	0.38 -0.14 to 0.89	0.37 0.07 to 0.67	0.36 -0.11 to 0.82	0.32 -0.02 to 0.66	0.29 -0.34 to 0.89	0.28 -0.06 to 0.62	0.27 -0.22 to 0.73	0.25 0.03 to 0.48	0.24 -0.22 to 0.70	0.23 0.00 to 0.45	0.22 -0.07 to 0.52	0.21 -0.12 to 0.54	0.15 -0.50 to 0.78	0.15 -0.98 to 1.23	0.10 -0.54 to 0.69	0.09 -0.44 to 0.61	0.07 -0.29 to 0.43	0.06 -0.37 to 0.49	0.06 -0.44 to 0.53	0.01 -0.76 to 0.77	-0.00 -0.53 to 0.53	EXEN_SC_10UG_BID	-0.00 -0.49 to 0.51	-0.03 -0.57 to 0.51	-0.04 -0.27 to 0.18	-0.04 -0.42 to 0.33	-0.05 -0.58 to 0.45	-0.06 -0.53 to 0.42	-0.07 -0.45 to 0.29	-0.12 -0.69 to 0.41	-0.15 -0.66 to 0.39	-0.17 -0.72 to 0.36	-0.19 -0.76 to 0.38	-0.24 -0.49 to 0.02	-0.32 -0.85 to 0.22	-0.37 -0.91 to 0.18	-0.41 -0.79 to -0.03	-0.49 -1.27 to 0.29	-0.55 -1.28 to 0.18	-6.53 -8.29 to -4.73
PIOGLITAZONE	-0.83 -1.32 to -0.33	0.82 0.29 to 1.36	0.79 0.06 to 1.50	0.62 -0.07 to 1.30	0.39 -0.33 to 1.10	0.37 -0.16 to 0.90	0.36 -0.28 to 1.00	0.33 -0.22 to 0.87	0.29 -0.47 to 1.05	0.28 -0.28 to 0.85	0.28 -0.38 to 0.91	0.26 -0.21 to 0.73	0.24 -0.39 to 0.87	0.24 -0.27 to 0.72	0.23 -0.29 to 0.75	0.21 -0.33 to 0.78	0.15 -0.62 to 0.91	0.16 -1.06 to 1.34	0.10 -0.66 to 0.83	0.08 -0.64 to 0.82	0.08 -0.50 to 0.65	0.06 -0.56 to 0.67	0.06 -0.60 to 0.71	0.02 -0.86 to 0.88	0.00 -0.70 to 0.71	0.00 -0.51 to 0.49	PIOGLITAZONE	-0.03 -0.73 to 0.67	-0.04 -0.53 to 0.45	-0.04 -0.61 to 0.54	-0.05 -0.69 to 0.61	-0.06 -0.73 to 0.62	-0.07 -0.70 to 0.55	-0.13 -0.83 to 0.58	-0.14 -0.78 to 0.53	-0.17 -0.86 to 0.52	-0.19 -0.90 to 0.54	-0.24 -0.71 to 0.23	-0.32 -1.01 to 0.36	-0.36 -1.06 to 0.32	-0.41 -0.99 to 0.17	-0.49 -1.37 to 0.40	-0.54 -1.37 to 0.26	-6.52 -8.34 to -4.68
COTA_SC_200UG_QD	-0.80 -1.30 to -0.30	0.84 0.28 to 1.43	0.82 0.06 to 1.57	0.65 -0.08 to 1.38	0.41 -0.34 to 1.15	0.40 -0.16 to 0.97	0.38 -0.26 to 1.06	0.35 -0.23 to 0.93	0.32 -0.46 to 1.08	0.31 -0.28 to 0.92	0.31 -0.37 to 0.97	0.28 -0.26 to 0.83	0.27 -0.40 to 0.93	0.27 -0.28 to 0.79	0.25 -0.30 to 0.82	0.24 -0.35 to 0.84	0.18 -0.64 to 0.98	0.18 -1.09 to 1.40	0.12 -0.65 to 0.90	0.12 -0.64 to 0.88	0.10 -0.50 to 0.72	0.09 -0.55 to 0.72	0.08 -0.62 to 0.76	0.05 -0.86 to 0.93	0.03 -0.67 to 0.74	0.03 -0.51 to 0.57	0.03 -0.67 to 0.73	COTA_SC_200UG_QD	-0.01 -0.55 to 0.53	-0.01 -0.60 to 0.58	-0.02 -0.73 to 0.69	-0.03 -0.71 to 0.68	-0.04 -0.70 to 0.59	-0.10 -0.58 to 0.37	-0.12 -0.82 to 0.62	-0.14 -0.87 to 0.58	-0.16 -0.66 to 0.34	-0.21 -0.76 to 0.35	-0.29 -0.99 to 0.42	-0.34 -1.06 to 0.38	-0.38 -0.99 to 0.24	-0.46 -1.37 to 0.45	-0.52 -1.41 to 0.35	-6.50 -8.30 to -4.63
INS_GLARGINE	-0.79 -0.98 to -0.59	0.85 0.58 to 1.15	0.83 0.25 to 1.39	0.66 0.10 to 1.20	0.42 -0.15 to 0.99	0.41 0.16 to 0.66	0.39 -0.02 to 0.81	0.36 0.06 to 0.66	0.32 -0.29 to 0.93	0.32 -0.04 to 0.69	0.31 -0.12 to 0.75	0.29 0.08 to 0.51	0.28 -0.18 to 0.73	0.27 0.06 to 0.48	0.26 -0.02 to 0.56	0.25 -0.11 to 0.61	0.19 -0.42 to 0.79	0.19 -0.96 to 1.29	0.14 -0.48 to 0.73	0.12 -0.43 to 0.69	0.11 -0.23 to 0.44	0.10 -0.31 to 0.51	0.09 -0.37 to 0.55	0.05 -0.71 to 0.79	0.04 -0.48 to 0.57	0.04 -0.18 to 0.27	0.04 -0.45 to 0.53	0.01 -0.53 to 0.55	INS_GLARGINE	-0.00 -0.36 to 0.36	-0.01 -0.53 to 0.49	-0.02 -0.53 to 0.50	-0.03 -0.47 to 0.39	-0.09 -0.64 to 0.45	-0.11 -0.63 to 0.43	-0.13 -0.69 to 0.40	-0.15 -0.70 to 0.42	-0.20 -0.44 to 0.04	-0.29 -0.81 to 0.25	-0.33 -0.87 to 0.21	-0.37 -0.72 to -0.03	-0.45 -1.23 to 0.33	-0.51 -1.23 to 0.21	-6.49 -8.22 to -4.70
LIRA_SC_0p6MG_QD	-0.79 -1.12 to -0.46	0.86 0.46 to 1.26	0.83 0.18 to 1.48	0.66 0.02 to 1.29	0.42 -0.23 to 1.06	0.41 0.01 to 0.81	0.40 -0.14 to 0.94	0.36 -0.07 to 0.78	0.33 -0.36 to 0.99	0.32 -0.14 to 0.78	0.31 -0.23 to 0.85	0.30 -0.08 to 0.68	0.28 -0.21 to 0.76	0.28 -0.07 to 0.62	0.27 -0.10 to 0.63	0.25 -0.20 to 0.71	0.19 -0.52 to 0.87	0.19 -0.99 to 1.33	0.14 -0.55 to 0.79	0.12 -0.51 to 0.78	0.11 -0.35 to 0.57	0.10 -0.34 to 0.53	0.09 -0.45 to 0.64	0.05 -0.77 to 0.88	0.04 -0.54 to 0.64	0.04 -0.33 to 0.42	0.04 -0.54 to 0.61	0.01 -0.58 to 0.60	0.00 -0.36 to 0.36	LIRA_SC_0p6MG_QD	-0.01 -0.60 to 0.55	-0.02 -0.60 to 0.58	-0.02 -0.57 to 0.48	-0.08 -0.68 to 0.50	-0.10 -0.69 to 0.51	-0.12 -0.74 to 0.48	-0.14 -0.78 to 0.47	-0.20 -0.57 to 0.18	-0.28 -0.87 to 0.32	-0.33 -0.92 to 0.27	-0.37 -0.83 to 0.10	-0.45 -1.27 to 0.36	-0.51 -1.29 to 0.26	-6.48 -8.26 to -4.64
SEMA_PO_7MG_QD	-0.78 -1.27 to -0.27	0.87 0.32 to 1.43	0.84 0.09 to 1.57	0.67 -0.02 to 1.38	0.43 -0.30 to 1.17	0.42 -0.12 to 0.98	0.41 -0.24 to 1.05	0.37 -0.19 to 0.95	0.34 -0.42 to 1.10	0.33 -0.21 to 0.91	0.32 -0.34 to 0.98	0.30 -0.20 to 0.83	0.29 -0.35 to 0.95	0.28 -0.20 to 0.78	0.28 -0.25 to 0.82	0.25 -0.29 to 0.85	0.20 -0.60 to 0.97	0.19 -1.03 to 1.41	0.15 -0.63 to 0.88	0.14 -0.59 to 0.89	0.12 -0.47 to 0.72	0.11 -0.50 to 0.73	0.11 -0.57 to 0.77	0.06 -0.85 to 0.94	0.05 -0.64 to 0.76	0.05 -0.45 to 0.58	0.05 -0.61 to 0.69	0.02 -0.69 to 0.73	0.01 -0.49 to 0.53	0.01 -0.55 to 0.60	SEMA_PO_7MG_QD	-0.01 -0.69 to 0.70	-0.01 -0.66 to 0.59	-0.08 -0.78 to 0.65	-0.09 -0.74 to 0.57	-0.12 -0.82 to 0.59	-0.14 -0.86 to 0.62	-0.19 -0.64 to 0.29	-0.27 -0.96 to 0.44	-0.31 -1.03 to 0.39	-0.36 -0.94 to 0.23	-0.44 -1.34 to 0.47	-0.50 -1.02 to 0.02	-6.47 -8.28 to -4.63
EXEN_SC_5UG_BID	-0.77 -1.26 to -0.28	0.87 0.34 to 1.41	0.85 0.10 to 1.58	0.68 -0.04 to 1.40	0.45 -0.28 to 1.14	0.43 -0.12 to 0.97	0.42 -0.24 to 1.06	0.38 -0.20 to 0.95	0.36 -0.44 to 1.11	0.34 -0.24 to 0.91	0.33 -0.33 to 0.99	0.32 -0.20 to 0.82	0.30 -0.36 to 0.94	0.29 -0.23 to 0.80	0.28 -0.27 to 0.84	0.27 -0.31 to 0.85	0.21 -0.61 to 0.98	0.21 -1.03 to 1.41	0.16 -0.61 to 0.91	0.15 -0.57 to 0.85	0.13 -0.46 to 0.71	0.13 -0.51 to 0.74	0.11 -0.54 to 0.78	0.07 -0.83 to 0.99	0.06 -0.63 to 0.74	0.06 -0.42 to 0.53	0.06 -0.62 to 0.73	0.03 -0.68 to 0.71	0.02 -0.50 to 0.53	0.02 -0.58 to 0.60	0.01 -0.70 to 0.69	EXEN_SC_5UG_BID	-0.01 -0.64 to 0.59	-0.06 -0.78 to 0.63	-0.08 -0.79 to 0.61	-0.11 -0.84 to 0.60	-0.12 -0.86 to 0.58	-0.18 -0.71 to 0.33	-0.26 -0.95 to 0.43	-0.31 -1.03 to 0.40	-0.35 -0.95 to 0.22	-0.43 -1.32 to 0.48	-0.49 -1.37 to 0.36	-6.46 -8.28 to -4.61
INS_PREMIX	-0.76 -1.17 to -0.32	0.88 0.41 to 1.39	0.86 0.16 to 1.55	0.69 0.03 to 1.38	0.45 -0.17 to 1.09	0.44 -0.03 to 0.94	0.42 -0.16 to 1.03	0.39 -0.10 to 0.89	0.36 -0.36 to 1.05	0.35 -0.14 to 0.87	0.34 -0.26 to 0.95	0.32 -0.09 to 0.76	0.31 -0.27 to 0.91	0.30 -0.12 to 0.74	0.29 -0.17 to 0.78	0.28 -0.21 to 0.80	0.22 -0.52 to 0.97	0.22 -0.84 to 1.24	0.16 -0.55 to 0.85	0.15 -0.48 to 0.79	0.14 -0.36 to 0.66	0.13 -0.43 to 0.71	0.12 -0.48 to 0.74	0.08 -0.78 to 0.96	0.07 -0.56 to 0.73	0.07 -0.29 to 0.45	0.07 -0.55 to 0.70	0.04 -0.59 to 0.70	0.03 -0.39 to 0.47	0.02 -0.48 to 0.57	0.01 -0.59 to 0.66	0.01 -0.59 to 0.64	INS_PREMIX	-0.06 -0.69 to 0.60	-0.08 -0.69 to 0.59	-0.09 -0.74 to 0.54	-0.12 -0.78 to 0.56	-0.17 -0.60 to 0.29	-0.25 -0.88 to 0.40	-0.30 -0.93 to 0.36	-0.34 -0.88 to 0.20	-0.42 -1.27 to 0.46	-0.49 -1.27 to 0.34	-6.47 -8.23 to -4.58
COTA_SC_300UG_QD	-0.70 -1.18 to -0.19	0.94 0.38 to 1.52	0.91 0.15 to 1.66	0.76 0.01 to 1.49	0.51 -0.24 to 1.26	0.50 -0.07 to 1.07	0.49 -0.18 to 1.16	0.45 -0.14 to 1.03	0.42 -0.36 to 1.18	0.41 -0.17 to 1.01	0.40 -0.28 to 1.07	0.38 -0.16 to 0.94	0.37 -0.31 to 1.03	0.36 -0.19 to 0.90	0.35 -0.19 to 0.93	0.34 -0.25 to 0.94	0.28 -0.53 to 1.08	0.28 -0.97 to 1.52	0.22 -0.56 to 1.01	0.22 -0.51 to 0.95	0.20 -0.40 to 0.81	0.20 -0.46 to 0.82	0.18 -0.52 to 0.86	0.14 -0.76 to 1.03	0.13 -0.57 to 0.85	0.12 -0.41 to 0.69	0.13 -0.58 to 0.83	0.10 -0.37 to 0.58	0.09 -0.45 to 0.64	0.08 -0.50 to 0.68	0.08 -0.65 to 0.78	0.06 -0.63 to 0.78	0.06 -0.60 to 0.69	COTA_SC_300UG_QD	-0.02 -0.73 to 0.72	-0.04 -0.76 to 0.69	-0.06 -0.57 to 0.43	-0.12 -0.66 to 0.45	-0.19 -0.91 to 0.51	-0.24 -0.96 to 0.49	-0.28 -0.90 to 0.33	-0.36 -1.27 to 0.55	-0.41 -1.32 to 0.44	-6.39 -8.20 to -4.55
LIRA_SC_FLEX_1p2-1p8_QD	-0.69 -1.21 to -0.17	0.96 0.39 to 1.53	0.94 0.18 to 1.65	0.77 0.02 to 1.49	0.52 -0.21 to 1.24	0.52 -0.05 to 1.06	0.50 -0.18 to 1.17	0.46 -0.12 to 1.05	0.44 -0.35 to 1.20	0.43 -0.18 to 1.00	0.42 -0.26 to 1.07	0.40 -0.13 to 0.92	0.38 -0.29 to 1.03	0.38 -0.15 to 0.87	0.37 -0.19 to 0.92	0.36 -0.24 to 0.93	0.30 -0.52 to 1.07	0.30 -0.97 to 1.47	0.24 -0.54 to 1.00	0.23 -0.50 to 0.96	0.21 -0.39 to 0.80	0.21 -0.44 to 0.84	0.20 -0.47 to 0.86	0.16 -0.76 to 1.06	0.14 -0.57 to 0.88	0.15 -0.39 to 0.66	0.14 -0.53 to 0.78	0.12 -0.62 to 0.82	0.11 -0.43 to 0.63	0.10 -0.51 to 0.69	0.09 -0.57 to 0.74	0.08 -0.61 to 0.79	0.08 -0.59 to 0.69	0.02 -0.72 to 0.73	LIRA_SC_FLEX_1p2-1p8_QD	-0.02 -0.76 to 0.68	-0.05 -0.77 to 0.71	-0.10 -0.58 to 0.36	-0.18 -0.89 to 0.53	-0.22 -0.95 to 0.49	-0.26 -0.88 to 0.34	-0.34 -1.25 to 0.56	-0.40 -1.25 to 0.40	-6.38 -8.21 to -4.54
INS_DETEMIR	-0.67 -1.19 to -0.10	0.98 0.42 to 1.58	0.95 0.19 to 1.72	0.79 0.11 to 1.49	0.55 -0.18 to 1.31	0.54 -0.03 to 1.13	0.52 -0.14 to 1.20	0.49 -0.11 to 1.10	0.46 -0.32 to 1.24	0.45 -0.14 to 1.08	0.44 -0.25 to 1.13	0.43 -0.06 to 0.93	0.40 -0.26 to 1.09	0.40 -0.13 to 0.95	0.39 -0.17 to 0.98	0.37 -0.22 to 0.99	0.32 -0.49 to 1.12	0.32 -0.92 to 1.51	0.26 -0.53 to 1.04	0.25 -0.48 to 1.01	0.24 -0.37 to 0.87	0.24 -0.43 to 0.89	0.22 -0.46 to 0.91	0.18 -0.72 to 1.11	0.17 -0.54 to 0.91	0.17 -0.36 to 0.72	0.17 -0.52 to 0.86	0.14 -0.58 to 0.87	0.13 -0.40 to 0.69	0.12 -0.48 to 0.74	0.12 -0.59 to 0.82	0.11 -0.60 to 0.84	0.09 -0.54 to 0.74	0.04 -0.69 to 0.76	0.02 -0.68 to 0.76	INS_DETEMIR	-0.02 -0.75 to 0.74	-0.07 -0.61 to 0.49	-0.15 -0.88 to 0.60	-0.19 -0.91 to 0.52	-0.24 -0.87 to 0.39	-0.32 -1.22 to 0.60	-0.38 -1.27 to 0.48	-6.36 -8.20 to -4.46
COTA_SC_100UG_QD	-0.64 -1.17 to -0.12	1.00 0.42 to 1.60	0.98 0.20 to 1.72	0.82 0.06 to 1.56	0.57 -0.19 to 1.33	0.56 -0.04 to 1.14	0.54 -0.14 to 1.24	0.51 -0.11 to 1.12	0.48 -0.33 to 1.26	0.47 -0.14 to 1.09	0.46 -0.23 to 1.14	0.44 -0.13 to 1.01	0.43 -0.25 to 1.11	0.42 -0.14 to 0.97	0.41 -0.16 to 0.99	0.40 -0.22 to 1.01	0.33 -0.48 to 1.16	0.34 -0.94 to 1.58	0.28 -0.51 to 1.08	0.27 -0.49 to 1.05	0.26 -0.37 to 0.88	0.25 -0.45 to 0.90	0.25 -0.48 to 0.94	0.19 -0.69 to 1.11	0.19 -0.55 to 0.90	0.19 -0.38 to 0.76	0.19 -0.54 to 0.90	0.16 -0.34 to 0.66	0.15 -0.42 to 0.70	0.14 -0.47 to 0.78	0.14 -0.62 to 0.86	0.12 -0.58 to 0.86	0.12 -0.56 to 0.78	0.06 -0.43 to 0.57	0.05 -0.71 to 0.77	0.02 -0.74 to 0.75	COTA_SC_100UG_QD	-0.05 -0.62 to 0.51	-0.12 -0.86 to 0.59	-0.18 -0.93 to 0.55	-0.22 -0.85 to 0.40	-0.30 -1.22 to 0.62	-0.36 -1.28 to 0.52	-6.34 -8.16 to -4.46
SITAGLIPTIN	-0.59 -0.81 to -0.37	1.06 0.74 to 1.37	1.03 0.45 to 1.59	0.86 0.29 to 1.41	0.63 0.04 to 1.21	0.61 0.30 to 0.92	0.60 0.12 to 1.06	0.56 0.22 to 0.90	0.53 -0.08 to 1.13	0.52 0.18 to 0.87	0.51 0.02 to 0.99	0.50 0.25 to 0.74	0.48 0.02 to 0.94	0.48 0.26 to 0.67	0.47 0.18 to 0.75	0.45 0.10 to 0.80	0.39 -0.27 to 1.04	0.39 -0.77 to 1.51	0.34 -0.28 to 0.93	0.33 -0.25 to 0.91	0.31 -0.07 to 0.69	0.31 -0.13 to 0.73	0.29 -0.19 to 0.77	0.25 -0.52 to 1.02	0.24 -0.29 to 0.78	0.24 -0.02 to 0.49	0.24 -0.23 to 0.71	0.21 -0.35 to 0.76	0.20 -0.04 to 0.44	0.20 -0.18 to 0.57	0.19 -0.29 to 0.64	0.18 -0.33 to 0.71	0.17 -0.29 to 0.60	0.12 -0.45 to 0.66	0.10 -0.36 to 0.58	0.07 -0.49 to 0.61	0.05 -0.51 to 0.62	SITAGLIPTIN	-0.08 -0.62 to 0.46	-0.13 -0.67 to 0.40	-0.17 -0.55 to 0.21	-0.25 -1.04 to 0.54	-0.31 -1.00 to 0.37	-6.29 -8.03 to -4.49
PEGLOX_SC_300UG_QW	-0.51 -1.00 to -0.01	1.13 0.58 to 1.69	1.10 0.35 to 1.84	0.94 0.20 to 1.67	0.70 -0.03 to 1.44	0.70 0.13 to 1.25	0.68 0.01 to 1.31	0.64 0.07 to 1.20	0.61 -0.18 to 1.38	0.60 0.01 to 1.20	0.59 -0.10 to 1.27	0.58 0.02 to 1.11	0.56 -0.10 to 1.20	0.56 0.02 to 1.08	0.54 -0.00 to 1.10	0.53 -0.05 to 1.11	0.46 -0.33 to 1.27	0.46 -0.78 to 1.68	0.42 -0.36 to 1.17	0.41 -0.34 to 1.14	0.39 -0.21 to 0.98	0.38 -0.26 to 1.01	0.38 -0.30 to 1.02	0.34 -0.57 to 1.22	0.32 -0.18 to 0.83	0.32 -0.22 to 0.85	0.32 -0.36 to 1.01	0.29 -0.42 to 0.99	0.29 -0.25 to 0.81	0.28 -0.32 to 0.87	0.27 -0.44 to 0.96	0.26 -0.43 to 0.95	0.25 -0.40 to 0.88	0.19 -0.51 to 0.91	0.18 -0.53 to 0.89	0.15 -0.60 to 0.88	0.12 -0.59 to 0.86	0.08 -0.46 to 0.62	PEGLOX_SC_300UG_QW	-0.05 -0.78 to 0.68	-0.09 -0.69 to 0.51	-0.17 -1.08 to 0.73	-0.23 -1.09 to 0.63	-6.21 -8.03 to -4.34
OTHER_ACTIVE_sulfonylurea	-0.46 -0.99 to 0.07	1.18 0.63 to 1.76	1.16 0.42 to 1.85	0.99 0.27 to 1.72	0.75 -0.01 to 1.49	0.74 0.18 to 1.31	0.72 0.06 to 1.40	0.69 0.12 to 1.25	0.66 -0.11 to 1.41	0.65 0.04 to 1.27	0.64 -0.05 to 1.32	0.62 0.09 to 1.16	0.61 -0.06 to 1.29	0.60 0.11 to 1.09	0.59 0.04 to 1.15	0.58 -0.03 to 1.20	0.52 -0.28 to 1.29	0.52 -0.73 to 1.70	0.46 -0.30 to 1.19	0.45 -0.30 to 1.21	0.44 -0.16 to 1.03	0.43 -0.21 to 1.08	0.42 -0.23 to 1.09	0.38 -0.51 to 1.28	0.37 -0.34 to 1.10	0.37 -0.18 to 0.91	0.36 -0.32 to 1.06	0.34 -0.38 to 1.06	0.33 -0.21 to 0.87	0.33 -0.27 to 0.92	0.31 -0.39 to 1.03	0.31 -0.40 to 1.03	0.30 -0.36 to 0.93	0.24 -0.49 to 0.96	0.22 -0.49 to 0.95	0.19 -0.52 to 0.91	0.18 -0.55 to 0.93	0.13 -0.40 to 0.67	0.05 -0.68 to 0.78	OTHER_ACTIVE_sulfonylurea	-0.05 -0.66 to 0.57	-0.12 -1.04 to 0.82	-0.19 -1.04 to 0.69	-6.16 -7.98 to -4.28
LIXI_SC_20UG_QD	-0.42 -0.75 to -0.07	1.23 0.82 to 1.65	1.20 0.53 to 1.85	1.04 0.39 to 1.65	0.80 0.14 to 1.42	0.79 0.37 to 1.18	0.77 0.23 to 1.30	0.73 0.30 to 1.15	0.71 -0.00 to 1.38	0.69 0.22 to 1.16	0.68 0.25 to 1.10	0.67 0.27 to 1.05	0.65 0.10 to 1.18	0.65 0.26 to 1.01	0.64 0.22 to 1.05	0.62 0.15 to 1.09	0.56 -0.16 to 1.25	0.56 -0.62 to 1.70	0.51 -0.21 to 1.17	0.50 -0.16 to 1.15	0.48 0.01 to 0.94	0.47 -0.06 to 0.98	0.46 -0.10 to 1.03	0.42 -0.39 to 1.25	0.41 -0.18 to 1.01	0.41 0.03 to 0.79	0.41 -0.17 to 0.99	0.38 -0.24 to 0.99	0.37 0.03 to 0.72	0.37 -0.10 to 0.83	0.36 -0.23 to 0.94	0.35 -0.22 to 0.95	0.34 -0.20 to 0.88	0.28 -0.33 to 0.90	0.26 -0.34 to 0.88	0.24 -0.39 to 0.87	0.22 -0.40 to 0.85	0.17 -0.21 to 0.55	0.09 -0.51 to 0.69	0.05 -0.57 to 0.66	LIXI_SC_20UG_QD	-0.08 -0.88 to 0.74	-0.14 -0.94 to 0.65	-6.11 -7.87 to -4.30
OTHER_ACTIVE_testosterone	-0.34 -1.10 to 0.41	1.30 0.58 to 2.02	1.28 0.34 to 2.21	1.11 0.17 to 2.03	0.87 -0.06 to 1.81	0.86 0.06 to 1.64	0.84 0.01 to 1.69	0.80 -0.01 to 1.61	0.77 -0.20 to 1.73	0.77 -0.06 to 1.58	0.76 -0.13 to 1.64	0.75 -0.03 to 1.52	0.73 -0.14 to 1.59	0.72 -0.06 to 1.50	0.71 -0.06 to 1.51	0.69 -0.13 to 1.52	0.64 -0.34 to 1.60	0.64 -0.73 to 1.98	0.59 -0.37 to 1.53	0.57 -0.35 to 1.51	0.57 -0.26 to 1.38	0.55 -0.31 to 1.42	0.54 -0.33 to 1.42	0.51 -0.58 to 1.55	0.49 -0.41 to 1.39	0.49 -0.29 to 1.27	0.49 -0.40 to 1.37	0.46 -0.45 to 1.37	0.45 -0.33 to 1.23	0.45 -0.36 to 1.27	0.44 -0.47 to 1.34	0.43 -0.48 to 1.32	0.42 -0.46 to 1.27	0.36 -0.55 to 1.27	0.34 -0.56 to 1.25	0.32 -0.60 to 1.22	0.30 -0.62 to 1.22	0.25 -0.54 to 1.04	0.17 -0.73 to 1.08	0.12 -0.82 to 1.04	0.08 -0.74 to 0.88	OTHER_ACTIVE_testosterone	-0.06 -1.08 to 0.95	-6.03 -7.95 to -4.11
OTHER_ACTIVE_dpp4_inhibitor	-0.28 -0.99 to 0.45	1.37 0.62 to 2.12	1.35 0.44 to 2.21	1.18 0.31 to 2.04	0.93 0.04 to 1.84	0.92 0.17 to 1.68	0.91 0.06 to 1.73	0.87 0.11 to 1.64	0.85 -0.06 to 1.77	0.83 0.09 to 1.60	0.82 -0.01 to 1.67	0.81 0.10 to 1.53	0.79 -0.03 to 1.62	0.79 0.07 to 1.50	0.77 0.05 to 1.53	0.76 0.01 to 1.52	0.70 -0.27 to 1.65	0.70 -0.62 to 1.99	0.66 -0.27 to 1.55	0.64 -0.24 to 1.54	0.62 -0.14 to 1.41	0.62 -0.19 to 1.43	0.61 -0.23 to 1.44	0.57 -0.47 to 1.59	0.55 -0.30 to 1.42	0.55 -0.18 to 1.28	0.54 -0.26 to 1.37	0.52 -0.35 to 1.41	0.51 -0.21 to 1.23	0.51 -0.26 to 1.29	0.50 -0.02 to 1.02	0.49 -0.36 to 1.37	0.49 -0.34 to 1.27	0.41 -0.44 to 1.32	0.40 -0.40 to 1.25	0.38 -0.48 to 1.27	0.36 -0.52 to 1.28	0.31 -0.37 to 1.00	0.23 -0.63 to 1.09	0.19 -0.69 to 1.04	0.14 -0.65 to 0.94	0.06 -0.95 to 1.08	OTHER_ACTIVE_dpp4_inhibitor	-5.96 -7.85 to -4.02
DAPAGLIFLOZIN	5.70 3.91 to 7.44	7.34 5.58 to 9.07	7.31 5.43 to 9.14	7.15 5.27 to 8.96	6.91 5.08 to 8.76	6.90 5.12 to 8.66	6.87 5.05 to 8.67	6.84 5.06 to 8.60	6.81 4.94 to 8.68	6.80 4.98 to 8.58	6.80 4.95 to 8.60	6.78 4.97 to 8.52	6.76 4.92 to 8.56	6.76 4.97 to 8.50	6.75 4.93 to 8.50	6.72 4.92 to 8.51	6.67 4.77 to 8.53	6.68 4.52 to 8.77	6.61 4.77 to 8.47	6.61 4.74 to 8.46	6.60 4.79 to 8.36	6.58 4.76 to 8.36	6.57 4.72 to 8.38	6.54 4.59 to 8.45	6.52 4.65 to 8.33	6.53 4.73 to 8.29	6.52 4.68 to 8.34	6.50 4.63 to 8.30	6.49 4.70 to 8.22	6.48 4.64 to 8.26	6.47 4.63 to 8.28	6.46 4.61 to 8.28	6.47 4.58 to 8.23	6.39 4.55 to 8.20	6.38 4.54 to 8.21	6.36 4.46 to 8.20	6.34 4.46 to 8.16	6.29 4.49 to 8.03	6.21 4.34 to 8.03	6.16 4.28 to 7.98	6.11 4.30 to 7.87	6.03 4.11 to 7.95	5.96 4.02 to 7.85	DAPAGLIFLOZIN

Heterogeneity, fit and convergence

Bayesian random effects (primary)

Heterogeneity (tau): 0.216 (95% CrI 0.148 to 0.312)
Residual deviance: 143.9 for 135 data points
DIC: 265.9 (pD 122.1)
Largest R-hat: 1.002
Smallest ESS: bulk 1,412, tail 2,438
Divergent transitions: 0
Convergence: All criteria met
Priors: PR01 N(0, 5^2); PR03 N(0, 2.5^2); PR07 half normal(0, 0.5^2) on tau

Frequentist check (netmeta)

Method: inverse variance, REML, MD
Tau: 0.218
I squared: 74%
Q (total): 150.38 on 39 df, P = 0.000
Q (between designs): 111.93, P = 0.000

Inconsistency

Do trials comparing two treatments directly agree with the indirect evidence through other treatments?

No comparison here has both direct and indirect evidence, so inconsistency cannot be checked by node splitting; the between designs Q above is the global check.

Small study effects

A comparison adjusted funnel plot: each point is one trial comparison, centered on its own network estimate. Asymmetry can signal that small trials with unfavorable results are missing.

Fewer than ten trial comparisons, too few to judge funnel plot asymmetry.

Baseline characteristics of the trials

The baseline value of each effect modifier or prognostic factor that applies here, per trial: mean or percent over arms, weighted by the number randomized. A note under a value names a stand in (a median for a mean, 100 minus the male share, Asian subgroup rows, an all Asian site list); "not reported" means no source of the trial prints it.

Baseline effect modifiers and prognostic factors per trial
Trial	Baseline HbA1c (percent) effect modifier, prognostic factor; 54 of 58	Background glucose lowering therapy (stratum S0 to S4) effect modifier, prognostic factor; 58 of 58	Asian ancestry or region (percent Asian) effect modifier, prognostic factor; 39 of 58	Diabetes duration (years) effect modifier, prognostic factor; 48 of 58	Age (years) prognostic factor; 58 of 58	Treatment duration (weeks) effect modifier; 58 of 58
NCT00754988 S000027	7.96	S1	8.82	5.87	55.91	156
SEMAT S000079	7.15 median	S1	not reported	4	50 median	24
NCT01296412 S000080	8.15	S1	not reported	7.9	57.25	26
DUAL™ I China S000081	8.23	S1	100 region: all sites in Asia	8.17	54.7	26
DUAL™IV S000164	7.9	S1	16.56	9.1	59.8	26
NCT03235050 S000257	not reported	S1	0.72	not reported	56.79	54
NCT01029886 S000352	8.45	S1	12	8.49	57	26
NCT00637273 S000402	8.53	S1	24	5.67	52.53	26
NCT00717457 S000414	8.1	S1	not reported	6.6	55.67	52
SUSTAIN 9 S000483	8.05	S1	23.51	9.7	57.05	30
SUSTAIN 10 S000584	8.2	S1	1.39	9.3	59.5	30
NCT03951753 S000593	7.79	S1	0	11.33	61.91	28
NCT00935532 S000632	8.51	S1	100 region: all sites in Asia	not reported	56.75	26
NCT02008682 S000650	8.12	S1	100 region: all sites in Asia	5.25	51.55	26
NCT03878706 S000665	8.05	S1	not reported	6.5 median	57.5	52.14
NCT00577824 S000752	8.22	S1	100 region: all sites in Asia	12	58.43	24
NCT01149421 S000784	7.93	S1	9.14	8.34	56.48	26
NCT00434954 S000790	7.89	S1	not reported	5	57.05	26
NCT02229396 S000791	9.3	S1	0.72	7.37	54.17	104
EXENDA S000796	7.57	S1	not reported	6.6	60.1	24
NCT00395746 S000862	8.82	S1	100 region: all sites in Asia	10.33	59.67	52
NCT00135330 S000943	7.83	S1	not reported	4.7	55.7	20
LIRA-Ramadan™ S000963	8.25	S1	45.14	7.6	54.45	30
D-LIFT S000993	8.4	S1	100	5.3	47.35	24
NCT04451837 S001033	7.23	S1	not reported	4.6	66	26.07
LIRA-SWITCH™ S001119	8.25	S1	not reported	7.75	56.4	26
DUAL™ VIII S001131	not reported	S1	11.36	not reported	56.6	104
DURATION-NEO-2 S001157	8.45	S1	3.85	8.33	53.7	28
AWARD-6 S001184	8.05	S1	0.17	7.21	56.65	26
NCT00701935 S001193	not reported	S1	not reported	not reported	58.06	26.07
LixiLan-O S001199	8.1	S1	1.54	8.82	58.34	30
SUSTAIN™ 4 S001219	8.17	S1	not reported	8.6	56.47	30
DUALTM IX S001236	8.3	S1	15.75	9.55	56.65	26
NCT00877890 S001308	8.45	S1	not reported	not reported	55.66	24
NCT00360334 S001323	8.57	S1	not reported	8.7	56.5	26
NCT01003184 S001355	8.36	S1	4	7.5	58.5	26
AWARD-CHN2 S001404	8.37	S1	81.52	8.13	54.97	52
NCT00917267 S001437	8.7	S1	100 region: all sites in Asia	not reported	55.8	26
LEAD-2 S001502	8.38	S1	9	7.56	56.67	26
LIGHT-ON S001525	7.7	S1	100 region: all sites in Asia	4.46	44.84	26
GETGOAL-F1 S001563	8.04	S1	7.45	5.89	55	24
LEAD-1 S001584	8.44	S1	not reported	6.57 median	56.07	26
NCT00603239 S001737	not reported	S1	not reported	not reported	54.66	26
NCT00766857 S001750	7.69	S1	not reported	8 median	66	26
NCT00641056 S001768	8.3	S1	6	8	57.95	84
LEAD-5 S002098	8.26	S1	not reported	9.44	57.54	26
LEAD-6 S002230	8.15	S1	0.86	8.2	56.7	26
PIONEER 3 S002267	8.33	S1	13.14	not reported	57.75	78
NCT00700817 S002361	8.43	S1	1.65	6.23	55.3	26
S002928 S002928	7.3 median	S1	100 region: all sites in Asia	not reported	31.74	24
S002969 S002969	6.74 median	S1	not reported	3.48 median	52.3	26
S002984 S002984	8.67	S1	100 region: all sites in Asia	10.25	67.85	24
S003004 S003004	9.52 median	S1	100 region: all sites in Asia	not reported	51.95	26.07
S003006 S003006	8.25	S1	100 region: all sites in Asia	12.45	62.25	24
S003036 S003036	7.6	S1	100 region: all sites in Asia	14.04	66.13	24
S003044 S003044	8.5	S1	100 region: all sites in Asia	9.45 median	58.17	24
S003076 S003076	8.26	S1	not reported	5.72	52.87	24
S003086 S003086	9.68	S1	100 region: all sites in Asia	3 median	48.49	24

Comparability of the trials

Checked across designs (the set of treatments each trial compares) for eligibility, outcome definition and assessment, and the baseline factors above. Flags point to possible intransitivity; notes describe variation that is not tied to design.

FlagBaseline, Baseline HbA1c: design means range from 6.7 (LIRA_SC_1p8MG_QD vs PLACEBO) to 9.5 (BEIN_SC_FLEX_0p1-0p2_TID vs INS_PREMIX) percent; threshold 0.5
FlagBaseline, Diabetes duration: design means range from 3.5 (LIRA_SC_1p8MG_QD vs PLACEBO) to 14.0 (OTHER_ACTIVE_dpp4_inhibitor vs SEMA_PO_7MG_QD) years; threshold 3
FlagBaseline, Asian ancestry or region: not reported by 19 of 58 trials
FlagBaseline, Asian ancestry or region: design means range from 0.2 (DULA_SC_1p5MG_QW vs LIRA_SC_1p8MG_QD) to 100.0 (BEIN_SC_FLEX_0p1-0p2_TID vs INS_PREMIX) percent Asian; threshold 30
FlagBaseline, Age: design means range from 31.7 (PEGLOX_SC_300UG_QW vs PEGLOX_SC_400UG_QW vs PLACEBO) to 67.9 (INS_GLARGINE vs PEGLOX_SC_0p2MG_QW) years; threshold 10
FlagBaseline, Treatment duration: design means range from 20.0 (EXEN_SC_10UG_BID vs EXENROSI_SC_10-4UG_BID vs ROSIGLITAZONE) to 156.0 (PLACEBO vs SITAGLIPTIN vs TASP_SC_10MG_QW vs TASP_SC_20MG_QW) weeks; threshold 26
FlagEligibility, hba1c entry range: a design requires hba1c 42 or more while another admits only 9 or less
FlagEligibility, bmi entry range: a design requires bmi 50 or more while another admits only 35 or less
NoteOutcome assessment, time point: selected time points span 20 to 30 weeks
NoteOutcome assessment, analysis set: mixed: completers 8, full_analysis 18, modified_itt 25, per_protocol 3, randomized 4
NoteOutcome assessment, definition: mixed: change from baseline in HbA1c, LS mean ANCOVA, LOCF 1, change in HbA1c from baseline 1, HbA1c after 24 weeks 2, HbA1c change from baseline to endpoint, last observation on treatment carried forward 1, HbA1c change from baseline to week 24 1, HbA1c change from baseline to week 28, MMRM 1, HbA1c change from baseline, ITT 1, LS mean HbA1c change baseline to week 24, ANCOVA 1, not stated 48, Observed HbA1c at 6 months, mean and SD 1
NoteRisk of bias, blinding: mixed: double_blind 21, not_reported 2, open_label 33, single_blind 2
NoteRisk of bias, funding: mixed: industry 45, mixed 3, non_industry 10
NoteData handling, input conversions: arms_combined 1, median_converted 6, n_randomized 2

Comparability items per trial
Trial	time weeks	analysis set	definition	instrument	funding	adjudicated	proportion method	intercurrent events (discontinuation)	intercurrent events (rescue)	blinding	start year	Eligibility
NCT00754988	24	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2008	age 18 to 75; HbA1c 7.0 to 10.0 percent; BMI 25 (23 Asian) to 45; metformin at least 1500 mg
SEMAT	24	randomized	not stated	not stated	non_industry	not stated	not stated	not stated	not stated	open_label	2020	men 18 to 65; type 2 diabetes on oral agents; BMI above 30; functional hypogonadism with testosterone below 11 nmol/L
NCT01296412	26	per_protocol	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2011	age 18 to 79; HbA1c 7.0 to 11.0 percent on metformin 1500 mg or more; eGFR 60 or more
DUAL™ I China	26	full_analysis	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2017	Chinese adults 18 y or older; HbA1c 7.0 to 10.0; BMI 40 or less; metformin with or without one OAD
DUAL™IV	26	full_analysis	not stated	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2012	adults 18 or older; HbA1c 7.0 to 9.0 percent; BMI 40 or less; SU with or without metformin; insulin and GLP-1 RA naive
NCT03235050	26	full_analysis	not stated	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2017	age 18 or older; BMI 25 or higher; HbA1c 7.0 to 10.5 percent; on metformin
NCT01029886	26	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2010	adults 18 or older with type 2 diabetes on oral agents, HbA1c 7.1 to 11.0 percent, BMI 45 or less
NCT00637273	26	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2008	age 18 or older; HbA1c 7.1 to 11.0 percent; BMI 25 to 45; stable metformin
NCT00717457	24	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2008	age 18 to 75; HbA1c 7 to 10 percent; BMI 25 to 45 (above 23 for Asians); metformin with or without TZD
SUSTAIN 9	30	full_analysis	not stated	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2017	adults 18 or older (20 in Japan); HbA1c 7.0 to 10.5 percent; stable SGLT2i with or without metformin or SU
SUSTAIN 10	30	full_analysis	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2017	adults with T2D, HbA1c 7.0 to 11.0 percent on 1 to 3 oral drugs
NCT03951753	28	modified_itt	HbA1c change from baseline to week 28, MMRM	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2019	age 20 to 74; BMI 25 to 45; metformin with or without one other oral agent
NCT00935532	26	full_analysis	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2009	type 2 diabetes on biguanide with or without thiazolidinedione
NCT02008682	26	full_analysis	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2013	Chinese adults 18 to 80; HbA1c 7.0 to 10.0 on metformin; BMI 45 or lower
NCT03878706	26.07	completers	Observed HbA1c at 6 months, mean and SD	not stated	non_industry	not stated	not stated	not stated	not stated	single_blind	2017	T2D on metformin, HbA1c above 7 percent, high or very high CV risk, eGFR 60 or more
NCT00577824	24	full_analysis	HbA1c change from baseline to endpoint, last observation on treatment carried forward	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2008	age 20 to 75; HbA1c 7.0 to 10.0 percent JDS; weight 50 kg or more; sulfonylurea based oral therapy
NCT01149421	26	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2010	adults 18 or older; HbA1c 7 to 9.5 percent; stable oral agents
NCT00434954	26	full_analysis	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2007	adults with T2D on metformin, HbA1c 6.5 to 10.0 percent
NCT02229396	28	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2014	age 18 or older; HbA1c 8.0 to 12.0 percent on metformin 1500 mg/d or more
EXENDA	24	randomized	not stated	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2017	age 18 to 75; BMI 25 or more; HbA1c 6.5 to 11 percent; metformin 1000 mg or more
NCT00395746	24	full_analysis	not stated	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2006	age 20 or older; HbA1c 7.4 to 10.4 on one sulfonylurea
NCT00135330	20	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2005	age 18 to 75; BMI 25 to 40; HbA1c 6.8 to 10.0 percent; stable metformin only
LIRA-Ramadan™	26	full_analysis	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2014	age 18 to 80; HbA1c 7 to 10 percent; BMI 20 or more; metformin plus sulfonylurea; intent to fast in Ramadan
D-LIFT	24	per_protocol	not stated	not stated	non_industry	not stated	not stated	not stated	not stated	open_label	2019	age over 20; type 2 diabetes HbA1c 7.0 to 10.0; MRI-PDFF liver fat 6 percent or more
NCT04451837	26.07	modified_itt	not stated	not stated	non_industry	not stated	not stated	not stated	not stated	open_label	2020	age 18 or older; SIDD or SIRD cluster; stable metformin monotherapy; HbA1c 42 to 90 mmol/mol
LIRA-SWITCH™	26	full_analysis	not stated	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2013	age 18 or more; HbA1c 7.5 to 9.5 percent; BMI 20 or more; on sitagliptin 100 mg and metformin for 90 days or more
DUAL™ VIII	26	full_analysis	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2016	adults with type 2 diabetes uncontrolled on oral drugs, insulin naive
DURATION-NEO-2	28	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2013	age 18 or older; HbA1c 7.1 to 11.0 percent; BMI 45 or lower; metformin 1500 mg or more
AWARD-6	26	modified_itt	change in HbA1c from baseline	not stated	industry	not stated	not stated	not stated	not stated	open_label	2012	adults; HbA1c 7 to 10 percent; metformin 1500 mg/day or more
NCT00701935	26.07	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2008	adults with T2D on metformin
LixiLan-O	30	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2014	adults; HbA1c 7.5 to 10% on metformin or 7 to 9% on metformin plus second OAD; 7 to 10% after run in
SUSTAIN™ 4	30	full_analysis	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2014	adults with T2D, insulin naive, on metformin with or without SU; HbA1c 7.0 to 10.0 percent
DUALTM IX	26	full_analysis	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2016	adults; insulin naive type 2 diabetes on SGLT2 inhibitor with or without other oral drugs; HbA1c 7.0 to 11.0 percent; BMI 20 to 40
NCT00877890	24	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2009	age 18 or older; HbA1c 7.1 to 11.0 percent; BMI 25 to 45
NCT00360334	26	full_analysis	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2006	BMI above 27; HbA1c 7.5 to 10.0 percent; 2 or 3 oral drugs; at least one CV risk factor
NCT01003184	26	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2009	age 18 or older; HbA1c 7.1 to 10.0 percent; BMI 25 to 45; metformin with or without SU
AWARD-CHN2	26	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2012	age 18 or older; BMI 19 to 35 kg/m2; HbA1c 7.0 to 11.0 percent on metformin and/or sulfonylurea
NCT00917267	26	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2009	Asian adults 20 or older; HbA1c 7 to 11; BMI 21 to 35; on oral drugs
LEAD-2	26	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2006	age 18 to 80; HbA1c 7 to 11 percent on one OAD or 7 to 10 on combination; BMI 40 or less; no recent insulin
LIGHT-ON	26	randomized	not stated	not stated	mixed	not stated	not stated	not stated	not stated	open_label	2014	age 30 to 75, HbA1c 6.5 to 10 percent on metformin, NAFLD with MRI-PDFF over 10 percent, BMI 20 to 35
GETGOAL-F1	24	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2008	adults with T2D on metformin
LEAD-1	26	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2006	age 18 to 80; HbA1c 7.0 to 11.0 (mono) or 7.0 to 10.0 (combination); BMI up to 45
NCT00603239	26	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2008	type 2 diabetes on a thiazolidinedione with or without metformin
NCT00766857	26	completers	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2009	T2D with LVEF below 50; BMI 25 to 40; HbA1c 6.5 to 10.0; metformin with or without SU
NCT00641056	26	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2008	age 18 or older; HbA1c 7.1 to 11.0 percent; BMI 25 to 45; metformin with or without sulfonylurea
LEAD-5	26	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2006	age 18 to 80; HbA1c 7.5 to 10 on monotherapy or 7 to 10 on combination; BMI 45 or lower
LEAD-6	26	modified_itt	change from baseline in HbA1c, LS mean ANCOVA, LOCF	not stated	industry	not stated	not stated	not stated	not stated	open_label	2007	age 18 to 80; HbA1c 7.0 to 11.0 percent; BMI 45 or less; stable metformin, sulfonylurea or both
PIONEER 3	26	full_analysis	not stated	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2016	adults with T2D; HbA1c 7.0 to 10.5 percent; metformin with or without sulfonylurea
NCT00700817	26	full_analysis	not stated	not stated	industry	not stated	not stated	not stated	not stated	open_label	2008	age 18 to 80; HbA1c 7.5 to 10%; BMI 45 or less; metformin 1500 mg/day or more for 3 months
S002928	24	completers	LS mean HbA1c change baseline to week 24, ANCOVA	not stated	non_industry	not stated	not stated	not stated	not stated	single_blind	2022	age 18 to 65; BMI 50 or more; type 2 diabetes
S002969	26.07	modified_itt	not stated	not stated	industry	not stated	not stated	not stated	not stated	double_blind	2018	age 18 to 70; BMI 30 to 50; HbA1c 48 to below 97 mmol/mol; T2DM under 10 years; undergoing LAGB
S002984	24	per_protocol	HbA1c change from baseline to week 24	not stated	mixed	not stated	not stated	not stated	not stated	open_label	2020	T2D age 45 or older; HbA1c 7.0 to 11.0 percent; metformin at least 3 months
S003004	26.07	completers	not stated	not stated	non_industry	not stated	not stated	not stated	not stated	not_reported	2020	age 18 to 65; BMI 22 to 40; HbA1c 7 to 10 percent on metformin alone
S003006	24	completers	not stated	not stated	non_industry	not stated	not stated	not stated	not stated	open_label	2013	Japanese adults 20 or older; HbA1c 7.0 to below 10 on DPP-4 inhibitor based oral therapy
S003036	24	completers	not stated	not stated	non_industry	not stated	not stated	not stated	not stated	open_label	2022	age 20 or more; HbA1c 7.0 percent or more; DPP-4 inhibitor for 12 weeks or more
S003044	24	completers	HbA1c after 24 weeks	not stated	mixed	not stated	not stated	not stated	not stated	not_reported	2015	HbA1c 7.0 to <10.0%; BMI 18.5 to <25; waist >85 cm men, >80 cm women; stable oral agents
S003076	24	completers	HbA1c after 24 weeks	not stated	non_industry	not stated	not stated	not stated	not stated	open_label		postmenopausal women 45 to 65, type 2 diabetes on metformin only, HbA1c 7 to 10%, BMI above 30
S003086	24	randomized	HbA1c change from baseline, ITT	not stated	non_industry	not stated	not stated	not stated	not stated	double_blind	2017	age 18 to 65; HbA1c 6.5 percent or more; BMI 24 or more; SBP 90 to 130 mmHg

Trial data

What each trial contributes. Arm rows give the arm value with its standard error, or events over participants; contrast rows give the mean difference on the analysis scale against the trial's first row. Flags mark converted, combined or approximated inputs.

Trial data entering this analysis
Trial	Arm	Treatment	Week	Data	Value	SE	Events / N	Flags	Source
NCT00754988	A1	PLACEBO	24	arm, change	-0.100	0.080	90		R0022521:Abstract
NCT00754988	A2	TASP_SC_10MG_QW	24	arm, change	-1.230	0.060	182		R0022521:Results
NCT00754988	A3	TASP_SC_20MG_QW	24	arm, change	-1.300	0.060	187		R0022521:Results
NCT00754988	A4	SITAGLIPTIN	24	arm, change	-0.890	0.060	177		R0022521:Results
SEMAT	A1	SEMA_SC_1p0MG_QW	24	arm, change	-1.100	0.185	13	median_converted	R0019948:Table 1
SEMAT	A2	OTHER_ACTIVE_testosterone	24	arm, change	0.200	0.235	12	median_converted	R0019948:Table 1
NCT01296412	A1	SITAGLIPTIN	26	arm, change	-1.300	0.051	269		R0026295:Table 2
NCT01296412	A2	LIRA_SC_FLEX_1p2-1p8_QD	26	arm, change	-1.400	0.051	253		R0026295:Table 2
DUAL™ I China	A1	IDEGLIRA_SC_TIT_QD	26	arm, change	-1.710	0.048	341		registry:outcomes
DUAL™ I China	A2	INS_DEGLUDEC	26	arm, change	-1.200	0.077	167		registry:outcomes
DUAL™ I China	A3	LIRA_SC_1p8MG_QD	26	arm, change	-1.160	0.072	151		registry:outcomes
DUAL™IV	A1	IDEGLIRA_SC_TIT_QD	26	arm, change	-1.500	0.047	289		R0015199:Results
DUAL™IV	A2	PLACEBO	26	arm, change	-0.500	0.066	146		R0015199:Results
NCT03235050	A1	PLACEBO	26	arm, change	-0.400	0.092	112		registry:outcomes
NCT03235050	A3	COTA_SC_100UG_QD	26	arm, change	-1.060	0.097	100		registry:outcomes
NCT03235050	A4	COTA_SC_200UG_QD	26	arm, change	-1.220	0.061	256		registry:outcomes
NCT03235050	A5	COTA_SC_300UG_QD	26	arm, change	-1.120	0.061	256		registry:outcomes
NCT01029886	A1	EXENER_SC_2MG_QW	26	arm, change	-1.280	0.050	390		R0016299:Table 2
NCT01029886	A2	LIRA_SC_1p8MG_QD	26	arm, change	-1.480	0.050	386		R0016299:Table 2
NCT00637273	A1	EXENER_SC_2MG_QW	26	arm, change	-1.550	0.100	159		registry:outcomes
NCT00637273	A2	SITAGLIPTIN	26	arm, change	-0.920	0.099	162		registry:outcomes
NCT00637273	A3	PIOGLITAZONE	26	arm, change	-1.230	0.099	160		registry:outcomes
NCT00717457	A1	TASP_SC_10MG_QW	24	arm, change	-1.240	0.090	384		R0013639:Results
NCT00717457	A2	TASP_SC_20MG_QW	24	arm, change	-1.310	0.080	392		R0013639:Results
NCT00717457	A3	EXEN_SC_10UG_BID	24	arm, change	-0.980	0.080	373		R0013639:Results
SUSTAIN 9	A1	SEMA_SC_1p0MG_QW	30	arm, change	-1.600	0.065	151		registry:outcomes
SUSTAIN 9	A2	PLACEBO	30	arm, change	-0.200	0.073	151		registry:outcomes
SUSTAIN 10	A1	SEMA_SC_1p0MG_QW	30	arm, change	-1.700	0.053	290		registry:outcomes
SUSTAIN 10	A2	LIRA_SC_1p2MG_QD	30	arm, change	-1.100	0.059	287		registry:outcomes
NCT03951753	A2	SEMA_SC_1p0MG_QW	28	arm, change	-1.640	0.078	43		registry:outcomes
NCT03951753	A3	PLACEBO	28	arm, change	0.290	0.101	24		registry:outcomes
NCT00935532	A1	EXENER_SC_2MG_QW	26	arm, change	-1.110	0.060	214		registry:outcomes
NCT00935532	A2	INS_GLARGINE	26	arm, change	-0.680	0.060	212		registry:outcomes
NCT02008682	A1	LIRA_SC_1p8MG_QD	26	arm, change	-1.666	0.078	162		registry:outcomes
NCT02008682	A2	SITAGLIPTIN	26	arm, change	-0.969	0.074	175		registry:outcomes
NCT03878706	A1	OTHER_ACTIVE_basal_insulin	26.07	arm, final	6.900	0.141	50		R0006572:Table 3
NCT03878706	A2	LIRA_SC_1p8MG_QD	26.07	arm, final	7.000	0.127	50		R0006572:Table 3
NCT03878706	A3	EMPAGLIFLOZIN	26.07	arm, final	7.100	0.141	50		R0006572:Table 3
NCT03878706	A4	EMPALIRA_SC_1p8-25MG_QD	26.07	arm, final	6.400	0.113	50		R0006572:Table 3
NCT00577824	A1	PLACEBO	24	arm, change	-0.286	0.153	35		R0018881:Results
NCT00577824	A2	EXEN_SC_5UG_BID	24	arm, change	-1.367	0.112	71		R0018881:Results
NCT00577824	A3	EXEN_SC_10UG_BID	24	arm, change	-1.652	0.112	72		R0018881:Results
NCT01149421	A1	DULA_SC_1p5MG_QW	26	arm, change	-1.010	0.070	251		registry:outcomes
NCT01149421	A2	DULA_SC_0p75MG_QW	26	arm, change	-0.890	0.060	254		registry:outcomes
NCT01149421	A3	PLACEBO	26	arm, change	-0.020	0.060	250		registry:outcomes
NCT00434954	A1	EXEN_SC_10UG_BID	26	arm, change	-1.000	0.050	181		registry:outcomes
NCT00434954	A2	INS_PREMIX	26	arm, change	-1.140	0.050	173		registry:outcomes
NCT02229396	A1	DAPAEXEN_SC_2-10MG_QW	28	contrast, md	-0.380	0.129			registry:outcomes
NCT02229396	A2	EXENER_SC_2MG_QW	28	contrast, md					registry:outcomes
EXENDA	A1	EXENER_SC_2MG_QW	24	arm, change	-1.629	0.327	16		R0025594:Table 3
EXENDA	A2	PLACEBO	24	arm, change	-0.631	0.168	14		R0025594:Table 3
NCT00395746	A1	LIRA_SC_0p6MG_QD	24	arm, final	7.020	0.100	86		registry:outcomes
NCT00395746	A2	LIRA_SC_0p9MG_QD	24	arm, final	6.750	0.110	87		registry:outcomes
NCT00395746	A3	PLACEBO	24	arm, final	8.020	0.100	88		registry:outcomes
NCT00135330	A1	EXEN_SC_10UG_BID	20	arm, change	-0.900	0.100	45		R0027805:Table 1
NCT00135330	A2	EXENROSI_SC_10-4UG_BID	20	arm, change	-1.300	0.100	47		R0027805:Table 1
NCT00135330	A3	ROSIGLITAZONE	20	arm, change	-1.000	0.100	45		R0027805:Table 1
LIRA-Ramadan™	A1	LIRA_SC_1p8MG_QD	26	arm, change	-1.300	0.091	146		registry:outcomes
LIRA-Ramadan™	A2	OTHER_ACTIVE_sulfonylurea	26	arm, change	-0.700	0.072	156		registry:outcomes
D-LIFT	A1	STANDARD_CARE	24	arm, change	-1.300	0.200	25		R0016566:Table 3
D-LIFT	A2	DULA_SC_1p5MG_QW	24	arm, change	-1.600	0.200	27		R0016566:Table 3
NCT04451837	A1	SEMA_SC_1p0MG_QW	26.07	contrast, md	-8.200	0.944			R0007799:Results
NCT04451837	A2	DAPAGLIFLOZIN	26.07	contrast, md					R0007799:Results
LIRA-SWITCH™	A1	LIRA_SC_1p8MG_QD	26	arm, change	-1.146	0.073	176		registry:outcomes
LIRA-SWITCH™	A2	SITAGLIPTIN	26	arm, change	-0.529	0.075	182		registry:outcomes
DUAL™ VIII	A1	IDEGLIRA_SC_TIT_QD	26	arm, change	-1.990	0.051	506		registry:outcomes
DUAL™ VIII	A2	INS_GLARGINE	26	arm, change	-1.690	0.049	506		registry:outcomes
DURATION-NEO-2	A1	EXENER_SC_2MG_QW	28	arm, change	-1.130	0.110	181		R0010641:Table 2
DURATION-NEO-2	A2	SITAGLIPTIN	28	arm, change	-0.750	0.130	122		R0010641:Table 2
DURATION-NEO-2	A3	PLACEBO	28	arm, change	-0.400	0.190	61		R0010641:Table 2
AWARD-6	A1	DULA_SC_1p5MG_QW	26	arm, change	-1.420	0.050	279		registry:outcomes
AWARD-6	A2	LIRA_SC_1p8MG_QD	26	arm, change	-1.360	0.050	272		registry:outcomes
NCT00701935	A1	EXEN_SC_10UG_BID	26.07	arm, change	-0.690	0.120	42		registry:outcomes
NCT00701935	A2	PLACEBO	26.07	arm, change	0.190	0.150	33		registry:outcomes
LixiLan-O	A1	IGLARLIXI2_SC_TIT_QD	30	arm, change	-1.600	0.040	467		R0013783:Supplement Table S2
LixiLan-O	A2	INS_GLARGINE	30	arm, change	-1.300	0.040	464		R0013783:Supplement Table S2
LixiLan-O	A3	LIXI_SC_20UG_QD	30	arm, change	-0.900	0.050	233		R0013783:Supplement Table S2
SUSTAIN™ 4	A1	SEMA_SC_0p5MG_QW	30	arm, change	-1.210	0.050	362		registry:outcomes
SUSTAIN™ 4	A2	SEMA_SC_1p0MG_QW	30	arm, change	-1.640	0.050	360		registry:outcomes
SUSTAIN™ 4	A3	INS_GLARGINE	30	arm, change	-0.830	0.050	360		registry:outcomes
DUALTM IX	A1	IDEGLIRA_SC_TIT_QD	26	contrast, md	-0.340	0.071			registry:outcomes
DUALTM IX	A2	INS_GLARGINE	26	contrast, md					registry:outcomes
NCT00877890	A1	EXENER_SC_2MG_QW	24	arm, change	-1.570	0.104	126		registry:outcomes
NCT00877890	A2	EXEN_SC_10UG_BID	24	arm, change	-0.900	0.110	116		registry:outcomes
NCT00360334	A1	EXEN_SC_10UG_BID	26	arm, change	-1.250	0.090	98		R0024925:Table 2
NCT00360334	A2	INS_GLARGINE	26	arm, change	-1.260	0.090	102		R0024925:Table 2
NCT01003184	A1	EXENER_SC_2MG_QW	26	arm, change	-1.300	0.080	111		R0027663:Table 1
NCT01003184	A2	INS_DETEMIR	26	arm, change	-0.880	0.080	105		R0027663:Table 1
AWARD-CHN2	A1	DULA_SC_1p5MG_QW	26	arm, change	-1.730	0.067	253		R0023722:Results
AWARD-CHN2	A2	DULA_SC_0p75MG_QW	26	arm, change	-1.330	0.067	252		R0023722:Results
AWARD-CHN2	A3	INS_GLARGINE	26	arm, change	-1.160	0.067	250		R0023722:Results
NCT00917267	A1	EXENER_SC_2MG_QW	26	arm, change	-1.430	0.070	307		registry:outcomes
NCT00917267	A2	EXEN_SC_10UG_BID	26	arm, change	-1.120	0.070	263		registry:outcomes
LEAD-2	A1	LIRA_SC_0p6MG_QD	26	arm, change	-0.700	0.100	239		R0019848:Results
LEAD-2	A2	LIRA_SC_1p2MG_QD	26	arm, change	-1.000	0.100	232		R0019848:Results
LEAD-2	A3	LIRA_SC_1p8MG_QD	26	arm, change	-1.000	0.100	236		R0019848:Results
LEAD-2	A4	GLIMEPIRIDE	26	arm, change	-1.000	0.100	234		R0019848:Results
LEAD-2	A5	PLACEBO	26	arm, change	0.100	0.100	120		R0019848:Results
LIGHT-ON	A1	LIRA_SC_1p8MG_QD	26	arm, change	-1.000	0.184	24		R0024860:Table 2
LIGHT-ON	A2	SITAGLIPTIN	26	arm, change	-1.000	0.192	27		R0024860:Table 2
LIGHT-ON	A3	INS_GLARGINE	26	arm, change	-0.700	0.265	24		R0024860:Table 2
GETGOAL-F1	A1	PLACEBO	24	arm, change	-0.400	0.068	158		R0021439:Supplement Table 1
GETGOAL-F1	A2+A3	LIXI_SC_20UG_QD	24	arm, change	-0.855	0.051	308	arms_combined	R0021439:Supplement Table 1
LEAD-1	A2	LIRA_SC_1p2MG_QD	26	contrast, md	-1.300	0.102			R0026073:Results
LEAD-1	A4	PLACEBO	26	contrast, md					R0026073:Results
NCT00603239	A1	EXEN_SC_10UG_BID	26	arm, change	-0.840	0.200	110		registry:outcomes
NCT00603239	A2	PLACEBO	26	arm, change	-0.100	0.230	54		registry:outcomes
NCT00766857	A1	EXEN_SC_10UG_BID	26	arm, final	7.100	0.573	11		R0014891:Table 4
NCT00766857	A2	INS_GLARGINE	26	arm, final	6.800	0.202	12		R0014891:Table 4
NCT00641056	A1	EXENER_SC_2MG_QW	26	arm, change	-1.470	0.050	205		registry:outcomes
NCT00641056	A2	INS_GLARGINE	26	arm, change	-1.310	0.060	206		registry:outcomes
LEAD-5	A1	LIRA_SC_1p8MG_QD	26	arm, change	-1.330	0.090	230		R0027336:Results
LEAD-5	A2	PLACEBO	26	arm, change	-0.240	0.110	114		R0027336:Results
LEAD-5	A3	INS_GLARGINE	26	arm, change	-1.090	0.090	232		R0027336:Results
LEAD-6	A1	LIRA_SC_1p8MG_QD	26	arm, change	-1.120	0.080	227		registry:outcomes
LEAD-6	A2	EXEN_SC_10UG_BID	26	arm, change	-0.790	0.080	226		registry:outcomes
PIONEER 3	A2	SEMA_PO_7MG_QD	26	contrast, md	-0.200	0.077			registry:outcomes
PIONEER 3	A4	SITAGLIPTIN	26	contrast, md					registry:outcomes
NCT00700817	A1	LIRA_SC_1p2MG_QD	26	arm, change	-1.240	0.070	211		registry:outcomes
NCT00700817	A2	LIRA_SC_1p8MG_QD	26	arm, change	-1.500	0.060	214		registry:outcomes
NCT00700817	A3	SITAGLIPTIN	26	arm, change	-0.900	0.070	210		registry:outcomes
S002928	A1	PLACEBO	24	arm, change	-0.500	0.071	35		R0007034:Figure 3A
S002928	A2	PEGLOX_SC_300UG_QW	24	arm, change	-1.020	0.071	35		R0007034:Results
S002928	A3	PEGLOX_SC_400UG_QW	24	arm, change	-1.340	0.071	35		R0007034:Results
S002969	A1	LIRA_SC_1p8MG_QD	26.07	arm, change	-0.107	0.313	12	median_converted	R0010852:Table 2
S002969	A2	PLACEBO	26.07	arm, change	-0.335	0.263	13	median_converted	R0010852:Table 2
S002984	A1	PEGLOX_SC_0p2MG_QW	24	arm, change	-1.100	0.153	35		R0011969:Table 2
S002984	A2	INS_GLARGINE	24	arm, change	-0.900	0.153	34		R0011969:Table 2
S003004	A1	BEIN_SC_FLEX_0p1-0p2_TID	26.07	arm, final	6.673	0.354	49	median_converted	R0016204:Table 2
S003004	A2	INS_PREMIX	26.07	arm, final	6.983	0.360	52	median_converted	R0016204:Table 2
S003006	A1	INS_GLARGINE	24	arm, change	-1.000	0.177	26		R0010916:Results
S003006	A2	LIRA_SC_0p9MG_QD	24	arm, change	-0.600	0.149	29		R0010916:Results
S003036	A1	SEMA_PO_7MG_QD	24	arm, change	-0.500	0.102	24		R0017250:Results
S003036	A2	OTHER_ACTIVE_dpp4_inhibitor	24	arm, change	0.000	0.096	27		R0017250:Results
S003044	A1	EXEN_SC_10UG_BID	24	arm, final	7.050	0.164	40		R0023353:Table 2
S003044	A2	INS_PREMIX	24	arm, final	7.420	0.130	41		R0023353:Table 2
S003076	A1	EXEN_SC_10UG_BID	24	arm, final	7.320	0.336	15		R0019855:Table 1
S003076	A2	INS_GLARGINE	24	arm, final	7.120	0.121	15		R0019855:Table 1
S003086	A1	EXEN_SC_10UG_BID	24	arm, change	-2.574	0.227	79	n_randomized	R0019483:Table 2
S003086	A2	INS_GLARGINE	24	arm, change	-1.562	0.169	80	n_randomized	R0019483:Table 2

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