parallel randomized trial
S003004
Type 2 diabetes (adults)S003004
Design
Conduct and analysis
Arms
| Arm | Treatment | Background | Randomized | Analyzed | Completed treatment |
|---|---|---|---|---|---|
| A1 | Beinaglutide flexible dose injection three times daily Beinaglutide plus metformin | metformin; lifestyle: not reported | 67 | 49 | |
| A2 | Premixed insulin Aspart 30 plus metformin | metformin; lifestyle: not reported | 67 | 52 |
Baseline characteristics
As printed in the trial reports or registry, per arm or for the whole trial.
| Characteristic | Statistic | Beinaglutide flexible dose injection three times daily A1 | Premixed insulin A2 |
|---|---|---|---|
| age | mean (years) | 52.1 | 51.8 |
| age | sd (years) | 9.2 | 8.3 |
| bmi | mean (kg/m2) | 27.08 | 26.87 |
| bmi | sd (kg/m2) | 3.64 | 2.94 |
| hba1c | median (percent) | 9.45 | 9.60 |
| hba1c | q1 (percent) | 7.70 | 8.10 |
| hba1c | q3 (percent) | 11.22 | 11.91 |
| waist | mean (cm) | 98.15 | 97.44 |
| waist | sd (cm) | 9.67 | 8.29 |
| weight | mean (kg) | 84.34 | 83.12 |
| weight | sd (kg) | 13.86 | 16.09 |
Analyses this trial contributes to
- HbA1c changeType 2 diabetes (adults); weeks 20 to 36 (target week 26); network meta-analysis
- HbA1c changeType 2 diabetes (adults); weeks 20 to 36 (target week 26); network meta-analysis
- Body weight change in kilograms (diabetes)Type 2 diabetes (adults); weeks 20 to 36 (target week 26); network meta-analysis
- Body weight change in kilograms (diabetes)Type 2 diabetes (adults); weeks 20 to 36 (target week 26); network meta-analysis
Results
8 adjudicated result lines, grouped by outcome. Open an outcome to see its values.
HbA1c change (2 lines; O01)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| 26.07 | A1 | final | percent | 49 | not stated; completers; R0016204:Table 2 | ||
| 26.07 | A2 | final | percent | 52 | not stated; completers; R0016204:Table 2 |
Body weight change in kilograms (diabetes) (2 lines; O02)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| 26.07 | A1 | final | 79.30 kg | 12.92 | 49 | not stated; completers; R0016204:Table 2 | |
| 26.07 | A2 | final | 85.39 kg | 15.94 | 52 | not stated; completers; R0016204:Table 2 |
Level 2 or 3 hypoglycemia (participants) (2 lines; O04)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 0 / 67 | not stated; safety; R0016204:Discussion | ||||
| A1 | events | 0 / 67 | not stated; safety; R0016204:Discussion |
Discontinuation due to adverse events (2 lines; O26)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 4 / 67 | not stated; randomized; R0016204:Figure 1 | ||||
| A2 | events | 2 / 67 | not stated; randomized; R0016204:Figure 1 |