Arms

Arm	Treatment	Background	Randomized	Analyzed	Completed treatment
A1	Semaglutide 1.0 mg subcutaneous once weekly Semaglutide 1.0 mg once weekly	metformin 1500 mg/day or more; lifestyle: not reported	109
A2	Liraglutide 1.8 mg subcutaneous once daily Liraglutide 1.8 mg once daily	metformin 1500 mg/day or more; lifestyle: not reported	109

Baseline characteristics

As printed in the trial reports or registry, per arm or for the whole trial.

Characteristic	Statistic	Semaglutide 1.0 mg subcutaneous once weekly A1	Liraglutide 1.8 mg subcutaneous once daily A2
age	mean (years)	51.3	50.8
age	sd (years)	8.7	9.2
bmi	mean (kg/m2)	34.7	34.2
bmi	sd (kg/m2)	3.8	4.1
female	percent	58.7	55.0
hba1c	mean (percent)	8.4	8.3
hba1c	sd (percent)	1.1	1.0
sbp	mean (mmHg)	138.2	137.6
sbp	sd (mmHg)	13.7	14.1
waist	mean (cm)	108.4	107.1
waist	sd (cm)	11.6	12.3
weight	mean (kg)	97.6	96.1
weight	sd (kg)	14.3	15.2

26 adjudicated result lines, grouped by outcome. Open an outcome to see its values.

HbA1c change (5 lines; O01)

Week	Arm	Statistic	Estimate	SE or SD	95% CI	Detail
52	A1	change	-1.6 percent			not stated; other; R0053844:Table 2
52	A1	final	6.8 percent	0.7		not stated; other; R0053844:Table 2
52	A1 vs A2	md	-0.5 percent		-0.71 to -0.29	not stated; other; R0053844:p4
52	A2	change	-1.1 percent			not stated; other; R0053844:Table 2
52	A2	final	7.2 percent	0.9		not stated; other; R0053844:Table 2

Body weight change in kilograms (diabetes) (5 lines; O02)

Week	Arm	Statistic	Estimate	SE or SD	95% CI	Detail
52	A1	change	-9.3 kg			not stated; other; R0053844:Table 2
52	A1	final	88.3 kg	13.1		not stated; other; R0053844:Table 2
52	A1 vs A2	md	-3.5 kg		-4.87 to -2.13	not stated; other; R0053844:p4
52	A2	change	-5.8 kg			not stated; other; R0053844:Table 2
52	A2	final	90.3 kg	14.7		not stated; other; R0053844:Table 2

HbA1c below 7 percent (3 lines; O03)

Week	Arm	Statistic	Estimate	95% CI	Events / N	Detail
52	A1	responders	65.1		71 /	not stated; other; R0053844:Table 1
52	A1 vs A2	or	2.37	1.39 to 4.06		not stated; other; R0053844:Table 1
52	A2	responders	44.0		48 /	not stated; other; R0053844:Table 1

Systolic blood pressure change (5 lines; O05)

Week	Arm	Statistic	Estimate	SE or SD	Detail
52	A1	change	-6.8 mmHg		not stated; other; R0053844:Table 2
52	A1	final	131.4 mmHg	11.3	not stated; other; R0053844:Table 2
52	A1 vs A2	md	-2.4 mmHg		not stated; other; R0053844:p4
52	A2	change	-4.4 mmHg		not stated; other; R0053844:Table 2
52	A2	final	133.2 mmHg	12.7	not stated; other; R0053844:Table 2

Weight loss of 5 percent or more (3 lines; O11A)

Week	Arm	Statistic	Estimate	95% CI	Events / N	Detail
52	A1	responders	75.2		82 /	not stated; other; R0053844:Table 1
52	A1 vs A2	or	3.44	1.95 to 6.08		not stated; other; R0053844:Table 1
52	A2	responders	46.8		51 /	not stated; other; R0053844:Table 1

Weight loss of 10 percent or more (3 lines; O11B)

Week	Arm	Statistic	Estimate	95% CI	Events / N	Detail
52	A1	responders	37.6		41 /	not stated; other; R0053844:Table 1
52	A1 vs A2	or	4.10	2.08 to 8.09		not stated; other; R0053844:Table 1
52	A2	responders	12.8		14 /	not stated; other; R0053844:Table 1

Nausea (2 lines; O27A)

Week	Arm	Statistic	Estimate	SE or SD	95% CI	Events / N	Detail
	A1	events	31.7				not stated; other; R0053844:Abstract
	A2	events	26.3				not stated; other; R0053844:Abstract