Network meta-analysis
Body weight change in kilograms (diabetes)
Type 2 diabetes (adults); background therapy: one or more non insulin glucose lowering drugs
weeks 20 to 36 (target week 26)Not stated by the trialsEach dose separatelyMean difference
49
Randomized trials
38
Treatments
20,293
Participants
122
Trial arms
In plain language
Across 49 trials with 20,293 participants, 13 of 37 treatments had a clearly better result than placebo on body weight change in kilograms (diabetes), 8 a clearly worse one, and for 16 the evidence could not tell them apart from placebo. The most favorable estimate was for Polyethylene glycol loxenatide 400 µg injection once weekly: mean difference -13.86 kg (95% credible interval -18.13 to -9.75).
Lower values favor the treatment. "Clearly" means the 95% credible interval excludes no difference. These are averages across trials; they do not say how any one person will respond. Not medical advice.
Network of trials
Each circle is a treatment; each line joins treatments that were randomized against each other in at least one trial.
Effects compared with Placebo
Mean difference in kg. Lower values favor the treatment.
| Treatment | Bayesian MD (95% CrI) | 95% prediction interval | Frequentist MD (95% CI) | Verdict |
|---|---|---|---|---|
| Polyethylene glycol loxenatide 400 µg injection once weekly PEGLOX_SC_400UG_QW | -13.86 (-18.13 to -9.75) | -18.38 to -9.55 | -14.39 (-18.56 to -10.22) | Better |
| Tirzepatide 15 mg subcutaneous once weekly TIRZ_SC_15MG_QW | -9.59 (-12.14 to -7.00) | -12.63 to -6.64 | -9.77 (-12.34 to -7.21) | Better |
| Polyethylene glycol loxenatide 300 µg injection once weekly PEGLOX_SC_300UG_QW | -9.16 (-13.29 to -5.04) | -13.57 to -4.70 | -9.59 (-13.76 to -5.42) | Better |
| Semaglutide 1.0 mg subcutaneous once weekly SEMA_SC_1p0MG_QW | -4.46 (-5.52 to -3.46) | -6.36 to -2.63 | -4.50 (-5.49 to -3.51) | Better |
| Cotadutide 300 ug subcutaneous once daily COTA_SC_300UG_QD | -3.03 (-4.66 to -1.39) | -5.25 to -0.77 | -3.06 (-4.62 to -1.50) | Better |
| Beinaglutide flexible dose injection three times daily BEIN_SC_FLEX_0p1-0p2_TID | -2.71 (-8.62 to 3.26) | -8.89 to 3.42 | -3.60 (-9.66 to 2.46) | Unclear |
| Semaglutide 0.5 mg subcutaneous once weekly SEMA_SC_0p5MG_QW | -2.60 (-4.28 to -0.95) | -4.86 to -0.35 | -2.63 (-4.17 to -1.08) | Better |
| Liraglutide flexible dose injection once daily LIRA_SC_FLEX_1p2-1p8_QD | -2.26 (-4.12 to -0.38) | -4.66 to 0.10 | -2.28 (-4.03 to -0.54) | Better |
| Cotadutide 200 ug subcutaneous once daily COTA_SC_200UG_QD | -2.23 (-3.85 to -0.62) | -4.54 to 0.05 | -2.25 (-3.81 to -0.69) | Better |
| Taspoglutide 20 mg subcutaneous once weekly TASP_SC_20MG_QW | -1.74 (-3.05 to -0.48) | -3.77 to 0.24 | -1.76 (-2.99 to -0.54) | Better |
| Liraglutide 1.8 mg subcutaneous once daily LIRA_SC_1p8MG_QD | -1.69 (-2.41 to -1.02) | -3.39 to -0.01 | -1.71 (-2.37 to -1.05) | Better |
| Exenatide 10 ug subcutaneous twice daily EXEN_SC_10UG_BID | -1.65 (-2.41 to -0.90) | -3.45 to 0.07 | -1.68 (-2.42 to -0.94) | Better |
| Cotadutide 100 ug subcutaneous once daily COTA_SC_100UG_QD | -1.47 (-3.28 to 0.33) | -3.93 to 0.86 | -1.51 (-3.23 to 0.21) | Unclear |
| Lixisenatide 20 ug subcutaneous once daily LIXI_SC_20UG_QD | -1.14 (-2.45 to 0.14) | -3.15 to 0.80 | -1.14 (-2.38 to 0.10) | Unclear |
| Liraglutide 1.2 mg subcutaneous once daily LIRA_SC_1p2MG_QD | -1.13 (-2.18 to -0.11) | -3.00 to 0.73 | -1.13 (-2.09 to -0.18) | Better |
| Exenatide extended release 2 mg subcutaneous once weekly EXENER_SC_2MG_QW | -1.07 (-1.88 to -0.28) | -2.85 to 0.66 | -1.08 (-1.84 to -0.32) | Better |
| Dulaglutide 1.5 mg subcutaneous once weekly DULA_SC_1p5MG_QW | -0.99 (-2.22 to 0.24) | -2.97 to 0.98 | -1.01 (-2.18 to 0.16) | Unclear |
| Taspoglutide 10 mg subcutaneous once weekly TASP_SC_10MG_QW | -0.98 (-2.25 to 0.28) | -3.04 to 0.98 | -1.01 (-2.24 to 0.21) | Unclear |
| Liraglutide 0.9 mg injection once daily LIRA_SC_0p9MG_QD | -0.25 (-1.37 to 0.84) | -2.23 to 1.58 | -0.26 (-1.31 to 0.79) | Unclear |
| Exenatide 5 ug subcutaneous twice daily EXEN_SC_5UG_BID | -0.24 (-1.82 to 1.37) | -2.48 to 2.01 | -0.26 (-1.77 to 1.26) | Unclear |
| Dulaglutide 0.75 mg subcutaneous once weekly DULA_SC_0p75MG_QW | -0.22 (-1.42 to 1.04) | -2.25 to 1.81 | -0.22 (-1.39 to 0.94) | Unclear |
| Exenatide and rosiglitazone 10 to 4 µg injection twice daily EXENROSI_SC_10-4UG_BID | -0.06 (-2.37 to 2.11) | -2.84 to 2.66 | -0.08 (-2.23 to 2.07) | Unclear |
| Liraglutide 0.6 mg subcutaneous once daily LIRA_SC_0p6MG_QD | 0.08 (-1.02 to 1.15) | -1.86 to 2.04 | 0.07 (-0.95 to 1.09) | Unclear |
| Visepegenatide 150 µg injection once weekly VISEPE_SC_150UG_QW | 0.10 (-1.51 to 1.67) | -2.12 to 2.38 | 0.11 (-1.41 to 1.63) | Unclear |
| Sitagliptin SITAGLIPTIN | 0.13 (-0.65 to 0.88) | -1.64 to 1.84 | 0.12 (-0.62 to 0.85) | Unclear |
| IGlarLixi 2:1 pen subcutaneous once daily titrated IGLARLIXI2_SC_TIT_QD | 0.82 (-0.85 to 2.46) | -1.56 to 3.06 | 0.81 (-0.76 to 2.38) | Unclear |
| Insulin degludec and liraglutide (IDegLira) subcutaneous once daily titrated IDEGLIRA_SC_TIT_QD | 0.98 (-0.09 to 2.00) | -0.93 to 2.86 | 0.98 (0.01 to 1.95) | Unclear |
| Standard care or no added treatment STANDARD_CARE | 1.31 (-1.27 to 3.84) | -1.74 to 4.31 | 1.29 (-1.23 to 3.81) | Unclear |
| Insulin degludec INS_DEGLUDEC | 2.08 (0.47 to 3.64) | -0.17 to 4.31 | 2.08 (0.56 to 3.60) | Worse |
| Insulin glargine INS_GLARGINE | 2.18 (1.46 to 2.88) | 0.44 to 3.89 | 2.17 (1.49 to 2.84) | Worse |
| Sulfonylurea OTHER_ACTIVE_sulfonylurea | 2.22 (0.39 to 4.07) | -0.23 to 4.59 | 2.23 (0.51 to 3.95) | Worse |
| Insulin detemir INS_DETEMIR | 2.43 (0.34 to 4.45) | -0.18 to 5.00 | 2.42 (0.50 to 4.34) | Worse |
| Glimepiride GLIMEPIRIDE | 2.48 (1.03 to 3.91) | 0.33 to 4.59 | 2.48 (1.14 to 3.82) | Worse |
| Rosiglitazone ROSIGLITAZONE | 2.63 (0.32 to 4.88) | -0.06 to 5.35 | 2.62 (0.47 to 4.77) | Worse |
| Premixed insulin INS_PREMIX | 2.63 (0.76 to 4.21) | 0.09 to 4.83 | 2.49 (0.83 to 4.15) | Worse |
| Testosterone OTHER_ACTIVE_testosterone | 3.24 (-2.42 to 8.89) | -2.65 to 9.06 | 3.43 (-2.38 to 9.25) | Unclear |
| Pioglitazone PIOGLITAZONE | 3.85 (2.14 to 5.52) | 1.47 to 6.12 | 3.85 (2.23 to 5.46) | Worse |
Ranking
How likely each treatment is to be among the best. Rankings ignore the size of differences and their certainty, so read them with the effects above.
League table
Every treatment against every other: mean difference of the row treatment versus the column treatment, posterior median and 95% credible interval. Green: row clearly better; red: row clearly worse.
| Row versus column | PLACEBO | PEGLOX_SC_400UG_QW | TIRZ_SC_15MG_QW | PEGLOX_SC_300UG_QW | SEMA_SC_1p0MG_QW | COTA_SC_300UG_QD | BEIN_SC_FLEX_0p1-0p2_TID | SEMA_SC_0p5MG_QW | LIRA_SC_FLEX_1p2-1p8_QD | COTA_SC_200UG_QD | TASP_SC_20MG_QW | LIRA_SC_1p8MG_QD | EXEN_SC_10UG_BID | COTA_SC_100UG_QD | LIXI_SC_20UG_QD | LIRA_SC_1p2MG_QD | EXENER_SC_2MG_QW | DULA_SC_1p5MG_QW | TASP_SC_10MG_QW | LIRA_SC_0p9MG_QD | EXEN_SC_5UG_BID | DULA_SC_0p75MG_QW | EXENROSI_SC_10-4UG_BID | LIRA_SC_0p6MG_QD | VISEPE_SC_150UG_QW | SITAGLIPTIN | IGLARLIXI2_SC_TIT_QD | IDEGLIRA_SC_TIT_QD | STANDARD_CARE | INS_DEGLUDEC | INS_GLARGINE | OTHER_ACTIVE_sulfonylurea | INS_DETEMIR | GLIMEPIRIDE | ROSIGLITAZONE | INS_PREMIX | OTHER_ACTIVE_testosterone | PIOGLITAZONE |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PLACEBO | PLACEBO | 13.86 9.75 to 18.13 | 9.59 7.00 to 12.14 | 9.16 5.04 to 13.29 | 4.46 3.46 to 5.52 | 3.03 1.39 to 4.66 | 2.71 -3.26 to 8.62 | 2.60 0.95 to 4.28 | 2.26 0.38 to 4.12 | 2.23 0.62 to 3.85 | 1.74 0.48 to 3.05 | 1.69 1.02 to 2.41 | 1.65 0.90 to 2.41 | 1.47 -0.33 to 3.28 | 1.14 -0.14 to 2.45 | 1.13 0.11 to 2.18 | 1.07 0.28 to 1.88 | 0.99 -0.24 to 2.22 | 0.98 -0.28 to 2.25 | 0.25 -0.84 to 1.37 | 0.24 -1.37 to 1.82 | 0.22 -1.04 to 1.42 | 0.06 -2.11 to 2.37 | -0.08 -1.15 to 1.02 | -0.10 -1.67 to 1.51 | -0.13 -0.88 to 0.65 | -0.82 -2.46 to 0.85 | -0.98 -2.00 to 0.09 | -1.31 -3.84 to 1.27 | -2.08 -3.64 to -0.47 | -2.18 -2.88 to -1.46 | -2.22 -4.07 to -0.39 | -2.43 -4.45 to -0.34 | -2.48 -3.91 to -1.03 | -2.63 -4.88 to -0.32 | -2.63 -4.21 to -0.76 | -3.24 -8.89 to 2.42 | -3.85 -5.52 to -2.14 |
| PEGLOX_SC_400UG_QW | -13.86 -18.13 to -9.75 | PEGLOX_SC_400UG_QW | -4.26 -9.28 to 0.63 | -4.73 -8.92 to -0.50 | -9.38 -13.80 to -5.13 | -10.83 -15.39 to -6.56 | -11.19 -18.33 to -4.00 | -11.26 -15.62 to -6.88 | -11.58 -16.18 to -7.18 | -11.64 -16.20 to -7.32 | -12.09 -16.55 to -7.88 | -12.16 -16.43 to -8.04 | -12.20 -16.58 to -8.04 | -12.40 -16.90 to -8.00 | -12.70 -17.15 to -8.46 | -12.71 -17.05 to -8.51 | -12.79 -17.18 to -8.62 | -12.86 -17.25 to -8.65 | -12.86 -17.30 to -8.60 | -13.59 -17.97 to -9.37 | -13.63 -18.07 to -9.26 | -13.62 -18.08 to -9.40 | -13.77 -18.56 to -9.17 | -13.92 -18.33 to -9.69 | -13.94 -18.56 to -9.61 | -13.99 -18.34 to -9.83 | -14.67 -19.16 to -10.29 | -14.83 -19.19 to -10.63 | -15.18 -20.10 to -10.28 | -15.95 -20.48 to -11.48 | -16.02 -20.31 to -11.88 | -16.08 -20.74 to -11.66 | -16.28 -21.11 to -11.82 | -16.33 -20.88 to -11.95 | -16.48 -21.32 to -11.77 | -16.45 -21.01 to -12.03 | -17.12 -24.08 to -10.30 | -17.70 -22.24 to -13.34 |
| TIRZ_SC_15MG_QW | -9.59 -12.14 to -7.00 | 4.26 -0.63 to 9.28 | TIRZ_SC_15MG_QW | -0.49 -5.32 to 4.62 | -5.11 -7.64 to -2.55 | -6.55 -9.61 to -3.55 | -6.87 -13.37 to -0.40 | -6.97 -9.88 to -4.09 | -7.30 -10.52 to -4.21 | -7.38 -10.40 to -4.38 | -7.83 -10.67 to -4.95 | -7.89 -10.51 to -5.27 | -7.94 -10.59 to -5.31 | -8.11 -11.26 to -5.02 | -8.46 -11.27 to -5.59 | -8.46 -11.13 to -5.77 | -8.52 -11.13 to -5.88 | -8.59 -11.44 to -5.69 | -8.60 -11.44 to -5.72 | -9.32 -12.14 to -6.53 | -9.36 -12.31 to -6.34 | -9.37 -12.20 to -6.48 | -9.49 -12.93 to -6.13 | -9.66 -12.46 to -6.85 | -9.67 -12.73 to -6.70 | -9.72 -12.34 to -7.04 | -10.41 -13.48 to -7.32 | -10.56 -13.30 to -7.82 | -10.88 -14.52 to -7.34 | -11.67 -14.65 to -8.61 | -11.75 -14.38 to -9.13 | -11.82 -15.04 to -8.72 | -12.03 -15.21 to -8.77 | -12.08 -14.89 to -9.07 | -12.21 -15.58 to -8.79 | -12.17 -15.24 to -9.05 | -12.83 -19.14 to -6.63 | -13.45 -16.46 to -10.34 |
| PEGLOX_SC_300UG_QW | -9.16 -13.29 to -5.04 | 4.73 0.50 to 8.92 | 0.49 -4.62 to 5.32 | PEGLOX_SC_300UG_QW | -4.67 -8.97 to -0.32 | -6.13 -10.61 to -1.69 | -6.47 -13.67 to 0.71 | -6.54 -11.03 to -2.13 | -6.88 -11.48 to -2.33 | -6.92 -11.34 to -2.48 | -7.42 -11.75 to -3.12 | -7.45 -11.61 to -3.22 | -7.48 -11.69 to -3.31 | -7.70 -12.17 to -3.23 | -7.98 -12.33 to -3.68 | -8.02 -12.24 to -3.76 | -8.09 -12.24 to -3.84 | -8.16 -12.40 to -3.88 | -8.19 -12.45 to -3.87 | -8.90 -13.06 to -4.64 | -8.93 -13.29 to -4.49 | -8.95 -13.25 to -4.58 | -9.09 -13.76 to -4.43 | -9.21 -13.50 to -4.98 | -9.26 -13.67 to -4.88 | -9.28 -13.43 to -5.08 | -9.96 -14.49 to -5.50 | -10.14 -14.37 to -5.79 | -10.45 -15.31 to -5.62 | -11.23 -15.66 to -6.75 | -11.33 -15.53 to -7.14 | -11.37 -15.86 to -6.86 | -11.55 -16.17 to -6.88 | -11.62 -16.07 to -7.18 | -11.76 -16.47 to -7.03 | -11.73 -16.17 to -7.28 | -12.36 -19.30 to -5.51 | -13.02 -17.36 to -8.53 |
| SEMA_SC_1p0MG_QW | -4.46 -5.52 to -3.46 | 9.38 5.13 to 13.80 | 5.11 2.55 to 7.64 | 4.67 0.32 to 8.97 | SEMA_SC_1p0MG_QW | -1.45 -3.44 to 0.42 | -1.77 -7.84 to 4.17 | -1.85 -3.47 to -0.27 | -2.21 -4.30 to -0.11 | -2.25 -4.20 to -0.33 | -2.73 -4.31 to -1.16 | -2.77 -3.89 to -1.67 | -2.82 -4.03 to -1.64 | -3.00 -5.06 to -0.94 | -3.33 -4.92 to -1.78 | -3.33 -4.53 to -2.20 | -3.40 -4.62 to -2.21 | -3.47 -5.07 to -1.95 | -3.48 -5.09 to -1.93 | -4.23 -5.63 to -2.80 | -4.22 -6.15 to -2.40 | -4.25 -5.85 to -2.75 | -4.39 -6.82 to -1.94 | -4.54 -5.98 to -3.17 | -4.57 -6.55 to -2.67 | -4.59 -5.78 to -3.44 | -5.28 -7.18 to -3.44 | -5.44 -6.84 to -4.12 | -5.77 -8.52 to -3.05 | -6.54 -8.35 to -4.71 | -6.64 -7.69 to -5.58 | -6.67 -8.82 to -4.70 | -6.90 -9.10 to -4.64 | -6.94 -8.62 to -5.27 | -7.09 -9.56 to -4.63 | -7.09 -8.96 to -5.02 | -7.70 -13.20 to -2.14 | -8.32 -10.22 to -6.43 |
| COTA_SC_300UG_QD | -3.03 -4.66 to -1.39 | 10.83 6.56 to 15.39 | 6.55 3.55 to 9.61 | 6.13 1.69 to 10.61 | 1.45 -0.42 to 3.44 | COTA_SC_300UG_QD | -0.35 -6.42 to 5.80 | -0.43 -2.69 to 1.86 | -0.76 -3.23 to 1.68 | -0.81 -2.60 to 0.99 | -1.27 -3.33 to 0.75 | -1.32 -2.98 to 0.32 | -1.37 -3.15 to 0.40 | -1.57 -3.44 to 0.38 | -1.89 -3.95 to 0.21 | -1.89 -3.73 to -0.04 | -1.95 -3.67 to -0.20 | -2.04 -4.09 to -0.01 | -2.05 -4.08 to 0.04 | -2.77 -4.68 to -0.83 | -2.77 -5.04 to -0.52 | -2.82 -4.85 to -0.81 | -2.97 -5.69 to -0.21 | -3.10 -4.97 to -1.22 | -3.12 -5.45 to -0.85 | -3.16 -4.87 to -1.42 | -3.83 -6.09 to -1.55 | -4.01 -5.89 to -2.09 | -4.34 -7.30 to -1.31 | -5.10 -7.27 to -2.79 | -5.20 -6.93 to -3.46 | -5.24 -7.64 to -2.87 | -5.46 -7.99 to -2.87 | -5.50 -7.59 to -3.39 | -5.66 -8.45 to -2.93 | -5.63 -7.90 to -3.18 | -6.26 -12.18 to -0.44 | -6.86 -9.12 to -4.54 |
| BEIN_SC_FLEX_0p1-0p2_TID | -2.71 -8.62 to 3.26 | 11.19 4.00 to 18.33 | 6.87 0.40 to 13.37 | 6.47 -0.71 to 13.67 | 1.77 -4.17 to 7.84 | 0.35 -5.80 to 6.42 | BEIN_SC_FLEX_0p1-0p2_TID | -0.09 -6.21 to 6.14 | -0.42 -6.72 to 5.86 | -0.47 -6.60 to 5.63 | -0.94 -6.96 to 5.05 | -1.00 -6.90 to 5.10 | -1.05 -6.99 to 4.91 | -1.26 -7.43 to 5.05 | -1.58 -7.58 to 4.51 | -1.59 -7.55 to 4.53 | -1.60 -7.58 to 4.35 | -1.71 -7.81 to 4.32 | -1.71 -7.76 to 4.30 | -2.45 -8.39 to 3.59 | -2.47 -8.57 to 3.67 | -2.50 -8.55 to 3.61 | -2.61 -8.89 to 3.66 | -2.80 -8.71 to 3.23 | -2.80 -8.87 to 3.38 | -2.83 -8.73 to 3.24 | -3.51 -9.69 to 2.50 | -3.68 -9.67 to 2.33 | -3.97 -10.50 to 2.56 | -4.75 -10.85 to 1.38 | -4.87 -10.83 to 1.15 | -4.92 -11.14 to 1.35 | -5.09 -11.29 to 1.12 | -5.17 -11.20 to 0.91 | -5.34 -11.63 to 0.96 | -5.30 -11.01 to 0.45 | -6.01 -14.22 to 2.13 | -6.52 -12.62 to -0.33 |
| SEMA_SC_0p5MG_QW | -2.60 -4.28 to -0.95 | 11.26 6.88 to 15.62 | 6.97 4.09 to 9.88 | 6.54 2.13 to 11.03 | 1.85 0.27 to 3.47 | 0.43 -1.86 to 2.69 | 0.09 -6.14 to 6.21 | SEMA_SC_0p5MG_QW | -0.33 -2.75 to 2.04 | -0.39 -2.61 to 1.94 | -0.86 -2.88 to 1.12 | -0.90 -2.61 to 0.76 | -0.95 -2.66 to 0.75 | -1.11 -3.54 to 1.20 | -1.47 -3.36 to 0.54 | -1.46 -3.28 to 0.32 | -1.54 -3.24 to 0.18 | -1.61 -3.56 to 0.36 | -1.63 -3.63 to 0.35 | -2.36 -4.25 to -0.44 | -2.36 -4.59 to -0.18 | -2.40 -4.39 to -0.43 | -2.52 -5.22 to 0.21 | -2.68 -4.58 to -0.76 | -2.71 -5.02 to -0.40 | -2.72 -4.46 to -1.01 | -3.43 -5.63 to -1.20 | -3.58 -5.40 to -1.73 | -3.90 -6.86 to -0.96 | -4.68 -6.82 to -2.42 | -4.78 -6.36 to -3.21 | -4.82 -7.22 to -2.44 | -5.05 -7.59 to -2.41 | -5.08 -7.18 to -2.95 | -5.24 -8.00 to -2.51 | -5.22 -7.41 to -2.80 | -5.82 -11.60 to -0.13 | -6.43 -8.71 to -4.24 |
| LIRA_SC_FLEX_1p2-1p8_QD | -2.26 -4.12 to -0.38 | 11.58 7.18 to 16.18 | 7.30 4.21 to 10.52 | 6.88 2.33 to 11.48 | 2.21 0.11 to 4.30 | 0.76 -1.68 to 3.23 | 0.42 -5.86 to 6.72 | 0.33 -2.04 to 2.75 | LIRA_SC_FLEX_1p2-1p8_QD | -0.05 -2.49 to 2.37 | -0.52 -2.70 to 1.68 | -0.57 -2.42 to 1.30 | -0.61 -2.58 to 1.32 | -0.80 -3.32 to 1.73 | -1.12 -3.30 to 1.09 | -1.13 -3.14 to 0.89 | -1.20 -3.07 to 0.72 | -1.28 -3.41 to 0.91 | -1.27 -3.47 to 0.88 | -2.01 -4.05 to 0.10 | -2.01 -4.42 to 0.42 | -2.04 -4.23 to 0.16 | -2.21 -5.06 to 0.78 | -2.34 -4.43 to -0.24 | -2.36 -4.81 to 0.14 | -2.40 -4.14 to -0.68 | -3.10 -5.50 to -0.65 | -3.23 -5.32 to -1.12 | -3.58 -6.65 to -0.41 | -4.34 -6.70 to -1.92 | -4.43 -6.32 to -2.52 | -4.49 -6.95 to -2.04 | -4.69 -7.36 to -2.01 | -4.75 -7.05 to -2.43 | -4.88 -7.79 to -1.93 | -4.88 -7.26 to -2.26 | -5.51 -11.51 to 0.40 | -6.11 -8.44 to -3.76 |
| COTA_SC_200UG_QD | -2.23 -3.85 to -0.62 | 11.64 7.32 to 16.20 | 7.38 4.38 to 10.40 | 6.92 2.48 to 11.34 | 2.25 0.33 to 4.20 | 0.81 -0.99 to 2.60 | 0.47 -5.63 to 6.60 | 0.39 -1.94 to 2.61 | 0.05 -2.37 to 2.49 | COTA_SC_200UG_QD | -0.48 -2.52 to 1.54 | -0.53 -2.13 to 1.10 | -0.56 -2.31 to 1.16 | -0.73 -2.66 to 1.16 | -1.09 -3.10 to 1.01 | -1.11 -2.90 to 0.73 | -1.16 -2.88 to 0.61 | -1.23 -3.26 to 0.85 | -1.23 -3.23 to 0.76 | -1.97 -3.85 to -0.09 | -1.99 -4.23 to 0.24 | -2.02 -4.00 to -0.02 | -2.15 -4.88 to 0.57 | -2.29 -4.16 to -0.42 | -2.33 -4.62 to -0.03 | -2.35 -4.06 to -0.63 | -3.03 -5.32 to -0.76 | -3.20 -5.05 to -1.35 | -3.53 -6.55 to -0.53 | -4.29 -6.46 to -2.09 | -4.40 -6.12 to -2.71 | -4.44 -6.80 to -2.11 | -4.65 -7.20 to -2.07 | -4.70 -6.82 to -2.62 | -4.86 -7.60 to -2.03 | -4.82 -7.10 to -2.39 | -5.44 -11.31 to 0.40 | -6.06 -8.31 to -3.78 |
| TASP_SC_20MG_QW | -1.74 -3.05 to -0.48 | 12.09 7.88 to 16.55 | 7.83 4.95 to 10.67 | 7.42 3.12 to 11.75 | 2.73 1.16 to 4.31 | 1.27 -0.75 to 3.33 | 0.94 -5.05 to 6.96 | 0.86 -1.12 to 2.88 | 0.52 -1.68 to 2.70 | 0.48 -1.54 to 2.52 | TASP_SC_20MG_QW | -0.04 -1.41 to 1.29 | -0.09 -1.41 to 1.21 | -0.27 -2.43 to 1.89 | -0.61 -2.36 to 1.14 | -0.61 -2.17 to 0.92 | -0.67 -2.05 to 0.71 | -0.74 -2.46 to 0.88 | -0.76 -2.06 to 0.55 | -1.49 -3.09 to 0.12 | -1.51 -3.50 to 0.48 | -1.53 -3.26 to 0.16 | -1.68 -4.12 to 0.83 | -1.82 -3.47 to -0.25 | -1.84 -3.85 to 0.23 | -1.86 -3.19 to -0.60 | -2.56 -4.60 to -0.56 | -2.72 -4.27 to -1.15 | -3.02 -5.86 to -0.24 | -3.81 -5.75 to -1.83 | -3.91 -5.28 to -2.60 | -3.97 -6.19 to -1.80 | -4.17 -6.49 to -1.81 | -4.23 -6.13 to -2.32 | -4.35 -6.89 to -1.81 | -4.35 -6.28 to -2.24 | -4.97 -10.70 to 0.78 | -5.59 -7.60 to -3.58 |
| LIRA_SC_1p8MG_QD | -1.69 -2.41 to -1.02 | 12.16 8.04 to 16.43 | 7.89 5.27 to 10.51 | 7.45 3.22 to 11.61 | 2.77 1.67 to 3.89 | 1.32 -0.32 to 2.98 | 1.00 -5.10 to 6.90 | 0.90 -0.76 to 2.61 | 0.57 -1.30 to 2.42 | 0.53 -1.10 to 2.13 | 0.04 -1.29 to 1.41 | LIRA_SC_1p8MG_QD | -0.05 -0.87 to 0.77 | -0.23 -2.06 to 1.56 | -0.56 -1.95 to 0.83 | -0.58 -1.56 to 0.47 | -0.63 -1.44 to 0.23 | -0.70 -2.07 to 0.64 | -0.72 -2.04 to 0.62 | -1.45 -2.61 to -0.26 | -1.46 -3.17 to 0.22 | -1.49 -2.88 to -0.14 | -1.63 -3.85 to 0.67 | -1.78 -2.94 to -0.61 | -1.80 -3.54 to -0.10 | -1.83 -2.56 to -1.12 | -2.52 -4.23 to -0.77 | -2.67 -3.71 to -1.61 | -3.01 -5.62 to -0.37 | -3.77 -5.27 to -2.24 | -3.88 -4.63 to -3.10 | -3.92 -5.62 to -2.25 | -4.13 -6.16 to -2.08 | -4.18 -5.64 to -2.74 | -4.33 -6.62 to -2.03 | -4.31 -5.97 to -2.38 | -4.92 -10.62 to 0.68 | -5.54 -7.23 to -3.80 |
| EXEN_SC_10UG_BID | -1.65 -2.41 to -0.90 | 12.20 8.04 to 16.58 | 7.94 5.31 to 10.59 | 7.48 3.31 to 11.69 | 2.82 1.64 to 4.03 | 1.37 -0.40 to 3.15 | 1.05 -4.91 to 6.99 | 0.95 -0.75 to 2.66 | 0.61 -1.32 to 2.58 | 0.56 -1.16 to 2.31 | 0.09 -1.21 to 1.41 | 0.05 -0.77 to 0.87 | EXEN_SC_10UG_BID | -0.18 -2.06 to 1.70 | -0.51 -1.86 to 0.87 | -0.52 -1.65 to 0.64 | -0.59 -1.40 to 0.25 | -0.65 -2.05 to 0.64 | -0.67 -1.94 to 0.63 | -1.40 -2.61 to -0.16 | -1.41 -2.98 to 0.15 | -1.43 -2.86 to -0.08 | -1.60 -3.66 to 0.55 | -1.72 -2.99 to -0.50 | -1.75 -3.53 to 0.02 | -1.78 -2.66 to -0.90 | -2.47 -4.16 to -0.73 | -2.62 -3.79 to -1.45 | -2.95 -5.60 to -0.39 | -3.73 -5.36 to -2.06 | -3.83 -4.65 to -3.01 | -3.86 -5.76 to -1.94 | -4.07 -6.15 to -1.99 | -4.12 -5.66 to -2.59 | -4.28 -6.39 to -2.17 | -4.26 -5.73 to -2.56 | -4.86 -10.56 to 0.77 | -5.49 -7.19 to -3.77 |
| COTA_SC_100UG_QD | -1.47 -3.28 to 0.33 | 12.40 8.00 to 16.90 | 8.11 5.02 to 11.26 | 7.70 3.23 to 12.17 | 3.00 0.94 to 5.06 | 1.57 -0.38 to 3.44 | 1.26 -5.05 to 7.43 | 1.11 -1.20 to 3.54 | 0.80 -1.73 to 3.32 | 0.73 -1.16 to 2.66 | 0.27 -1.89 to 2.43 | 0.23 -1.56 to 2.06 | 0.18 -1.70 to 2.06 | COTA_SC_100UG_QD | -0.33 -2.48 to 1.85 | -0.34 -2.35 to 1.66 | -0.40 -2.28 to 1.59 | -0.48 -2.60 to 1.70 | -0.50 -2.63 to 1.69 | -1.23 -3.25 to 0.84 | -1.23 -3.60 to 1.14 | -1.25 -3.41 to 0.87 | -1.42 -4.20 to 1.48 | -1.55 -3.60 to 0.49 | -1.58 -3.99 to 0.83 | -1.60 -3.47 to 0.32 | -2.29 -4.73 to 0.09 | -2.45 -4.49 to -0.44 | -2.77 -5.88 to 0.42 | -3.55 -5.88 to -1.19 | -3.65 -5.51 to -1.75 | -3.69 -6.13 to -1.22 | -3.90 -6.60 to -1.16 | -3.97 -6.21 to -1.67 | -4.10 -6.98 to -1.15 | -4.08 -6.44 to -1.54 | -4.66 -10.64 to 1.24 | -5.31 -7.71 to -2.90 |
| LIXI_SC_20UG_QD | -1.14 -2.45 to 0.14 | 12.70 8.46 to 17.15 | 8.46 5.59 to 11.27 | 7.98 3.68 to 12.33 | 3.33 1.78 to 4.92 | 1.89 -0.21 to 3.95 | 1.58 -4.51 to 7.58 | 1.47 -0.54 to 3.36 | 1.12 -1.09 to 3.30 | 1.09 -1.01 to 3.10 | 0.61 -1.14 to 2.36 | 0.56 -0.83 to 1.95 | 0.51 -0.87 to 1.86 | 0.33 -1.85 to 2.48 | LIXI_SC_20UG_QD | -0.01 -1.56 to 1.58 | -0.08 -1.47 to 1.35 | -0.15 -1.88 to 1.56 | -0.16 -1.87 to 1.58 | -0.89 -2.52 to 0.71 | -0.89 -2.96 to 1.08 | -0.93 -2.64 to 0.80 | -1.08 -3.63 to 1.46 | -1.21 -2.85 to 0.39 | -1.24 -3.31 to 0.77 | -1.27 -2.68 to 0.15 | -1.98 -3.58 to -0.32 | -2.11 -3.70 to -0.54 | -2.45 -5.30 to 0.34 | -3.20 -5.22 to -1.25 | -3.31 -4.61 to -2.06 | -3.36 -5.59 to -1.15 | -3.56 -5.90 to -1.18 | -3.61 -5.50 to -1.76 | -3.77 -6.36 to -1.20 | -3.76 -5.80 to -1.52 | -4.37 -10.11 to 1.46 | -4.98 -7.05 to -2.93 |
| LIRA_SC_1p2MG_QD | -1.13 -2.18 to -0.11 | 12.71 8.51 to 17.05 | 8.46 5.77 to 11.13 | 8.02 3.76 to 12.24 | 3.33 2.20 to 4.53 | 1.89 0.04 to 3.73 | 1.59 -4.53 to 7.55 | 1.46 -0.32 to 3.28 | 1.13 -0.89 to 3.14 | 1.11 -0.73 to 2.90 | 0.61 -0.92 to 2.17 | 0.58 -0.47 to 1.56 | 0.52 -0.64 to 1.65 | 0.34 -1.66 to 2.35 | 0.01 -1.58 to 1.56 | LIRA_SC_1p2MG_QD | -0.06 -1.21 to 1.10 | -0.13 -1.73 to 1.37 | -0.15 -1.66 to 1.42 | -0.89 -2.25 to 0.52 | -0.89 -2.74 to 0.92 | -0.91 -2.49 to 0.58 | -1.07 -3.46 to 1.39 | -1.21 -2.52 to 0.10 | -1.24 -3.14 to 0.66 | -1.26 -2.34 to -0.22 | -1.95 -3.83 to -0.07 | -2.10 -3.43 to -0.76 | -2.43 -5.17 to 0.31 | -3.20 -4.95 to -1.45 | -3.31 -4.40 to -2.21 | -3.34 -5.34 to -1.40 | -3.56 -5.79 to -1.30 | -3.60 -5.17 to -2.09 | -3.76 -6.23 to -1.29 | -3.75 -5.65 to -1.67 | -4.35 -9.98 to 1.35 | -4.97 -6.85 to -3.11 |
| EXENER_SC_2MG_QW | -1.07 -1.88 to -0.28 | 12.79 8.62 to 17.18 | 8.52 5.88 to 11.13 | 8.09 3.84 to 12.24 | 3.40 2.21 to 4.62 | 1.95 0.20 to 3.67 | 1.60 -4.35 to 7.58 | 1.54 -0.18 to 3.24 | 1.20 -0.72 to 3.07 | 1.16 -0.61 to 2.88 | 0.67 -0.71 to 2.05 | 0.63 -0.23 to 1.44 | 0.59 -0.25 to 1.40 | 0.40 -1.59 to 2.28 | 0.08 -1.35 to 1.47 | 0.06 -1.10 to 1.21 | EXENER_SC_2MG_QW | -0.06 -1.48 to 1.25 | -0.07 -1.46 to 1.27 | -0.82 -2.04 to 0.41 | -0.83 -2.54 to 0.87 | -0.85 -2.26 to 0.48 | -1.01 -3.25 to 1.30 | -1.14 -2.42 to 0.11 | -1.18 -3.01 to 0.61 | -1.19 -2.03 to -0.40 | -1.88 -3.61 to -0.16 | -2.03 -3.25 to -0.88 | -2.36 -4.98 to 0.23 | -3.13 -4.77 to -1.46 | -3.24 -4.03 to -2.48 | -3.28 -5.23 to -1.43 | -3.50 -5.37 to -1.61 | -3.54 -5.11 to -2.00 | -3.69 -5.98 to -1.42 | -3.67 -5.34 to -1.81 | -4.29 -10.00 to 1.34 | -4.91 -6.57 to -3.29 |
| DULA_SC_1p5MG_QW | -0.99 -2.22 to 0.24 | 12.86 8.65 to 17.25 | 8.59 5.69 to 11.44 | 8.16 3.88 to 12.40 | 3.47 1.95 to 5.07 | 2.04 0.01 to 4.09 | 1.71 -4.32 to 7.81 | 1.61 -0.36 to 3.56 | 1.28 -0.91 to 3.41 | 1.23 -0.85 to 3.26 | 0.74 -0.88 to 2.46 | 0.70 -0.64 to 2.07 | 0.65 -0.64 to 2.05 | 0.48 -1.70 to 2.60 | 0.15 -1.56 to 1.88 | 0.13 -1.37 to 1.73 | 0.06 -1.25 to 1.48 | DULA_SC_1p5MG_QW | -0.02 -1.68 to 1.74 | -0.74 -2.30 to 0.87 | -0.75 -2.72 to 1.25 | -0.78 -1.97 to 0.43 | -0.94 -3.35 to 1.62 | -1.07 -2.66 to 0.54 | -1.09 -3.10 to 0.93 | -1.12 -2.46 to 0.26 | -1.81 -3.80 to 0.20 | -1.98 -3.48 to -0.43 | -2.29 -4.58 to -0.04 | -3.06 -4.96 to -1.08 | -3.17 -4.38 to -1.93 | -3.21 -5.37 to -1.05 | -3.43 -5.68 to -1.06 | -3.47 -5.31 to -1.56 | -3.63 -6.15 to -1.01 | -3.63 -5.50 to -1.43 | -4.23 -9.96 to 1.50 | -4.84 -6.82 to -2.80 |
| TASP_SC_10MG_QW | -0.98 -2.25 to 0.28 | 12.86 8.60 to 17.30 | 8.60 5.72 to 11.44 | 8.19 3.87 to 12.45 | 3.48 1.93 to 5.09 | 2.05 -0.04 to 4.08 | 1.71 -4.30 to 7.76 | 1.63 -0.35 to 3.63 | 1.27 -0.88 to 3.47 | 1.23 -0.76 to 3.23 | 0.76 -0.55 to 2.06 | 0.72 -0.62 to 2.04 | 0.67 -0.63 to 1.94 | 0.50 -1.69 to 2.63 | 0.16 -1.58 to 1.87 | 0.15 -1.42 to 1.66 | 0.07 -1.27 to 1.46 | 0.02 -1.74 to 1.68 | TASP_SC_10MG_QW | -0.73 -2.36 to 0.85 | -0.75 -2.70 to 1.22 | -0.77 -2.52 to 0.95 | -0.91 -3.39 to 1.60 | -1.06 -2.67 to 0.56 | -1.10 -3.09 to 0.94 | -1.10 -2.44 to 0.17 | -1.80 -3.80 to 0.17 | -1.95 -3.53 to -0.37 | -2.25 -5.16 to 0.53 | -3.06 -5.01 to -1.08 | -3.16 -4.49 to -1.84 | -3.20 -5.35 to -1.04 | -3.42 -5.74 to -1.03 | -3.48 -5.36 to -1.50 | -3.61 -6.14 to -1.13 | -3.61 -5.50 to -1.43 | -4.21 -9.99 to 1.48 | -4.82 -6.83 to -2.80 |
| LIRA_SC_0p9MG_QD | -0.25 -1.37 to 0.84 | 13.59 9.37 to 17.97 | 9.32 6.53 to 12.14 | 8.90 4.64 to 13.06 | 4.23 2.80 to 5.63 | 2.77 0.83 to 4.68 | 2.45 -3.59 to 8.39 | 2.36 0.44 to 4.25 | 2.01 -0.10 to 4.05 | 1.97 0.09 to 3.85 | 1.49 -0.12 to 3.09 | 1.45 0.26 to 2.61 | 1.40 0.16 to 2.61 | 1.23 -0.84 to 3.25 | 0.89 -0.71 to 2.52 | 0.89 -0.52 to 2.25 | 0.82 -0.41 to 2.04 | 0.74 -0.87 to 2.30 | 0.73 -0.85 to 2.36 | LIRA_SC_0p9MG_QD | -0.02 -1.94 to 1.85 | -0.04 -1.64 to 1.51 | -0.19 -2.61 to 2.24 | -0.33 -1.61 to 0.98 | -0.37 -2.25 to 1.60 | -0.37 -1.54 to 0.76 | -1.07 -2.99 to 0.82 | -1.22 -2.66 to 0.18 | -1.56 -4.29 to 1.18 | -2.33 -4.17 to -0.45 | -2.42 -3.59 to -1.29 | -2.46 -4.61 to -0.44 | -2.68 -4.91 to -0.43 | -2.72 -4.50 to -1.00 | -2.88 -5.30 to -0.47 | -2.87 -4.74 to -0.75 | -3.46 -9.25 to 2.19 | -4.09 -5.97 to -2.18 |
| EXEN_SC_5UG_BID | -0.24 -1.82 to 1.37 | 13.63 9.26 to 18.07 | 9.36 6.34 to 12.31 | 8.93 4.49 to 13.29 | 4.22 2.40 to 6.15 | 2.77 0.52 to 5.04 | 2.47 -3.67 to 8.57 | 2.36 0.18 to 4.59 | 2.01 -0.42 to 4.42 | 1.99 -0.24 to 4.23 | 1.51 -0.48 to 3.50 | 1.46 -0.22 to 3.17 | 1.41 -0.15 to 2.98 | 1.23 -1.14 to 3.60 | 0.89 -1.08 to 2.96 | 0.89 -0.92 to 2.74 | 0.83 -0.87 to 2.54 | 0.75 -1.25 to 2.72 | 0.75 -1.22 to 2.70 | 0.02 -1.85 to 1.94 | EXEN_SC_5UG_BID | -0.03 -2.02 to 1.96 | -0.19 -2.77 to 2.53 | -0.32 -2.20 to 1.61 | -0.34 -2.62 to 1.92 | -0.37 -2.08 to 1.35 | -1.07 -3.33 to 1.15 | -1.22 -3.05 to 0.66 | -1.57 -4.48 to 1.47 | -2.31 -4.49 to -0.16 | -2.41 -4.08 to -0.72 | -2.44 -4.86 to -0.11 | -2.67 -5.17 to -0.06 | -2.71 -4.79 to -0.63 | -2.87 -5.50 to -0.20 | -2.85 -5.00 to -0.49 | -3.46 -9.30 to 2.46 | -4.08 -6.35 to -1.77 |
| DULA_SC_0p75MG_QW | -0.22 -1.42 to 1.04 | 13.62 9.40 to 18.08 | 9.37 6.48 to 12.20 | 8.95 4.58 to 13.25 | 4.25 2.75 to 5.85 | 2.82 0.81 to 4.85 | 2.50 -3.61 to 8.55 | 2.40 0.43 to 4.39 | 2.04 -0.16 to 4.23 | 2.02 0.02 to 4.00 | 1.53 -0.16 to 3.26 | 1.49 0.14 to 2.88 | 1.43 0.08 to 2.86 | 1.25 -0.87 to 3.41 | 0.93 -0.80 to 2.64 | 0.91 -0.58 to 2.49 | 0.85 -0.48 to 2.26 | 0.78 -0.43 to 1.97 | 0.77 -0.95 to 2.52 | 0.04 -1.51 to 1.64 | 0.03 -1.96 to 2.02 | DULA_SC_0p75MG_QW | -0.14 -2.63 to 2.44 | -0.28 -1.89 to 1.33 | -0.31 -2.30 to 1.73 | -0.33 -1.71 to 1.05 | -1.02 -3.00 to 0.99 | -1.18 -2.67 to 0.34 | -1.51 -4.07 to 1.05 | -2.28 -4.23 to -0.33 | -2.38 -3.62 to -1.14 | -2.43 -4.58 to -0.24 | -2.64 -4.90 to -0.30 | -2.70 -4.54 to -0.78 | -2.84 -5.39 to -0.28 | -2.83 -4.77 to -0.61 | -3.44 -9.19 to 2.34 | -4.07 -6.05 to -1.97 |
| EXENROSI_SC_10-4UG_BID | -0.06 -2.37 to 2.11 | 13.77 9.17 to 18.56 | 9.49 6.13 to 12.93 | 9.09 4.43 to 13.76 | 4.39 1.94 to 6.82 | 2.97 0.21 to 5.69 | 2.61 -3.66 to 8.89 | 2.52 -0.21 to 5.22 | 2.21 -0.78 to 5.06 | 2.15 -0.57 to 4.88 | 1.68 -0.83 to 4.12 | 1.63 -0.67 to 3.85 | 1.60 -0.55 to 3.66 | 1.42 -1.48 to 4.20 | 1.08 -1.46 to 3.63 | 1.07 -1.39 to 3.46 | 1.01 -1.30 to 3.25 | 0.94 -1.62 to 3.35 | 0.91 -1.60 to 3.39 | 0.19 -2.24 to 2.61 | 0.19 -2.53 to 2.77 | 0.14 -2.44 to 2.63 | EXENROSI_SC_10-4UG_BID | -0.15 -2.62 to 2.24 | -0.18 -2.91 to 2.58 | -0.19 -2.49 to 2.09 | -0.87 -3.63 to 1.84 | -1.04 -3.45 to 1.32 | -1.37 -4.69 to 2.02 | -2.14 -4.83 to 0.48 | -2.24 -4.54 to -0.03 | -2.29 -5.10 to 0.52 | -2.49 -5.53 to 0.45 | -2.54 -5.20 to 0.02 | -2.69 -4.80 to -0.69 | -2.69 -5.28 to 0.07 | -3.30 -9.43 to 2.75 | -3.92 -6.71 to -1.19 |
| LIRA_SC_0p6MG_QD | 0.08 -1.02 to 1.15 | 13.92 9.69 to 18.33 | 9.66 6.85 to 12.46 | 9.21 4.98 to 13.50 | 4.54 3.17 to 5.98 | 3.10 1.22 to 4.97 | 2.80 -3.23 to 8.71 | 2.68 0.76 to 4.58 | 2.34 0.24 to 4.43 | 2.29 0.42 to 4.16 | 1.82 0.25 to 3.47 | 1.78 0.61 to 2.94 | 1.72 0.50 to 2.99 | 1.55 -0.49 to 3.60 | 1.21 -0.39 to 2.85 | 1.21 -0.10 to 2.52 | 1.14 -0.11 to 2.42 | 1.07 -0.54 to 2.66 | 1.06 -0.56 to 2.67 | 0.33 -0.98 to 1.61 | 0.32 -1.61 to 2.20 | 0.28 -1.33 to 1.89 | 0.15 -2.24 to 2.62 | LIRA_SC_0p6MG_QD | -0.03 -1.96 to 1.91 | -0.05 -1.26 to 1.14 | -0.74 -2.71 to 1.23 | -0.90 -2.33 to 0.53 | -1.23 -3.99 to 1.55 | -1.99 -3.82 to -0.15 | -2.10 -3.29 to -0.88 | -2.14 -4.22 to -0.07 | -2.37 -4.57 to -0.08 | -2.41 -3.97 to -0.82 | -2.56 -5.01 to -0.11 | -2.55 -4.46 to -0.40 | -3.16 -8.94 to 2.55 | -3.77 -5.70 to -1.79 |
| VISEPE_SC_150UG_QW | 0.10 -1.51 to 1.67 | 13.94 9.61 to 18.56 | 9.67 6.70 to 12.73 | 9.26 4.88 to 13.67 | 4.57 2.67 to 6.55 | 3.12 0.85 to 5.45 | 2.80 -3.38 to 8.87 | 2.71 0.40 to 5.02 | 2.36 -0.14 to 4.81 | 2.33 0.03 to 4.62 | 1.84 -0.23 to 3.85 | 1.80 0.10 to 3.54 | 1.75 -0.02 to 3.53 | 1.58 -0.83 to 3.99 | 1.24 -0.77 to 3.31 | 1.24 -0.66 to 3.14 | 1.18 -0.61 to 3.01 | 1.09 -0.93 to 3.10 | 1.10 -0.94 to 3.09 | 0.37 -1.60 to 2.25 | 0.34 -1.92 to 2.62 | 0.31 -1.73 to 2.30 | 0.18 -2.58 to 2.91 | 0.03 -1.91 to 1.96 | VISEPE_SC_150UG_QW | -0.02 -1.81 to 1.72 | -0.71 -3.03 to 1.58 | -0.87 -2.79 to 1.05 | -1.20 -4.21 to 1.84 | -1.96 -4.25 to 0.29 | -2.08 -3.79 to -0.32 | -2.13 -4.59 to 0.32 | -2.33 -4.85 to 0.29 | -2.37 -4.49 to -0.24 | -2.51 -5.30 to 0.24 | -2.54 -4.72 to -0.02 | -3.11 -9.00 to 2.69 | -3.74 -6.06 to -1.41 |
| SITAGLIPTIN | 0.13 -0.65 to 0.88 | 13.99 9.83 to 18.34 | 9.72 7.04 to 12.34 | 9.28 5.08 to 13.43 | 4.59 3.44 to 5.78 | 3.16 1.42 to 4.87 | 2.83 -3.24 to 8.73 | 2.72 1.01 to 4.46 | 2.40 0.68 to 4.14 | 2.35 0.63 to 4.06 | 1.86 0.60 to 3.19 | 1.83 1.12 to 2.56 | 1.78 0.90 to 2.66 | 1.60 -0.32 to 3.47 | 1.27 -0.15 to 2.68 | 1.26 0.22 to 2.34 | 1.19 0.40 to 2.03 | 1.12 -0.26 to 2.46 | 1.10 -0.17 to 2.44 | 0.37 -0.76 to 1.54 | 0.37 -1.35 to 2.08 | 0.33 -1.05 to 1.71 | 0.19 -2.09 to 2.49 | 0.05 -1.14 to 1.26 | 0.02 -1.72 to 1.81 | SITAGLIPTIN | -0.70 -2.40 to 1.05 | -0.84 -2.01 to 0.32 | -1.17 -3.78 to 1.48 | -1.94 -3.56 to -0.28 | -2.05 -2.88 to -1.20 | -2.09 -3.91 to -0.33 | -2.31 -4.33 to -0.24 | -2.35 -3.85 to -0.82 | -2.49 -4.81 to -0.16 | -2.49 -4.17 to -0.54 | -3.11 -8.80 to 2.59 | -3.71 -5.34 to -2.09 |
| IGLARLIXI2_SC_TIT_QD | 0.82 -0.85 to 2.46 | 14.67 10.29 to 19.16 | 10.41 7.32 to 13.48 | 9.96 5.50 to 14.49 | 5.28 3.44 to 7.18 | 3.83 1.55 to 6.09 | 3.51 -2.50 to 9.69 | 3.43 1.20 to 5.63 | 3.10 0.65 to 5.50 | 3.03 0.76 to 5.32 | 2.56 0.56 to 4.60 | 2.52 0.77 to 4.23 | 2.47 0.73 to 4.16 | 2.29 -0.09 to 4.73 | 1.98 0.32 to 3.58 | 1.95 0.07 to 3.83 | 1.88 0.16 to 3.61 | 1.81 -0.20 to 3.80 | 1.80 -0.17 to 3.80 | 1.07 -0.82 to 2.99 | 1.07 -1.15 to 3.33 | 1.02 -0.99 to 3.00 | 0.87 -1.84 to 3.63 | 0.74 -1.23 to 2.71 | 0.71 -1.58 to 3.03 | 0.70 -1.05 to 2.40 | IGLARLIXI2_SC_TIT_QD | -0.16 -2.06 to 1.74 | -0.48 -3.46 to 2.55 | -1.24 -3.50 to 0.96 | -1.35 -2.96 to 0.23 | -1.39 -3.83 to 0.94 | -1.60 -4.16 to 1.02 | -1.66 -3.82 to 0.47 | -1.80 -4.54 to 0.94 | -1.81 -4.02 to 0.64 | -2.42 -8.34 to 3.49 | -3.05 -5.31 to -0.75 |
| IDEGLIRA_SC_TIT_QD | 0.98 -0.09 to 2.00 | 14.83 10.63 to 19.19 | 10.56 7.82 to 13.30 | 10.14 5.79 to 14.37 | 5.44 4.12 to 6.84 | 4.01 2.09 to 5.89 | 3.68 -2.33 to 9.67 | 3.58 1.73 to 5.40 | 3.23 1.12 to 5.32 | 3.20 1.35 to 5.05 | 2.72 1.15 to 4.27 | 2.67 1.61 to 3.71 | 2.62 1.45 to 3.79 | 2.45 0.44 to 4.49 | 2.11 0.54 to 3.70 | 2.10 0.76 to 3.43 | 2.03 0.88 to 3.25 | 1.98 0.43 to 3.48 | 1.95 0.37 to 3.53 | 1.22 -0.18 to 2.66 | 1.22 -0.66 to 3.05 | 1.18 -0.34 to 2.67 | 1.04 -1.32 to 3.45 | 0.90 -0.53 to 2.33 | 0.87 -1.05 to 2.79 | 0.84 -0.32 to 2.01 | 0.16 -1.74 to 2.06 | IDEGLIRA_SC_TIT_QD | -0.33 -2.96 to 2.38 | -1.09 -2.56 to 0.39 | -1.20 -2.26 to -0.16 | -1.25 -3.28 to 0.75 | -1.45 -3.65 to 0.82 | -1.51 -3.20 to 0.17 | -1.65 -4.05 to 0.75 | -1.65 -3.52 to 0.46 | -2.28 -8.06 to 3.41 | -2.87 -4.78 to -0.95 |
| STANDARD_CARE | 1.31 -1.27 to 3.84 | 15.18 10.28 to 20.10 | 10.88 7.34 to 14.52 | 10.45 5.62 to 15.31 | 5.77 3.05 to 8.52 | 4.34 1.31 to 7.30 | 3.97 -2.56 to 10.50 | 3.90 0.96 to 6.86 | 3.58 0.41 to 6.65 | 3.53 0.53 to 6.55 | 3.02 0.24 to 5.86 | 3.01 0.37 to 5.62 | 2.95 0.39 to 5.60 | 2.77 -0.42 to 5.88 | 2.45 -0.34 to 5.30 | 2.43 -0.31 to 5.17 | 2.36 -0.23 to 4.98 | 2.29 0.04 to 4.58 | 2.25 -0.53 to 5.16 | 1.56 -1.18 to 4.29 | 1.57 -1.47 to 4.48 | 1.51 -1.05 to 4.07 | 1.37 -2.02 to 4.69 | 1.23 -1.55 to 3.99 | 1.20 -1.84 to 4.21 | 1.17 -1.48 to 3.78 | 0.48 -2.55 to 3.46 | 0.33 -2.38 to 2.96 | STANDARD_CARE | -0.75 -3.72 to 2.24 | -0.87 -3.45 to 1.67 | -0.92 -4.07 to 2.27 | -1.13 -4.29 to 2.18 | -1.17 -4.19 to 1.71 | -1.33 -4.77 to 2.03 | -1.31 -4.23 to 1.84 | -1.92 -8.18 to 4.37 | -2.52 -5.56 to 0.47 |
| INS_DEGLUDEC | 2.08 0.47 to 3.64 | 15.95 11.48 to 20.48 | 11.67 8.61 to 14.65 | 11.23 6.75 to 15.66 | 6.54 4.71 to 8.35 | 5.10 2.79 to 7.27 | 4.75 -1.38 to 10.85 | 4.68 2.42 to 6.82 | 4.34 1.92 to 6.70 | 4.29 2.09 to 6.46 | 3.81 1.83 to 5.75 | 3.77 2.24 to 5.27 | 3.73 2.06 to 5.36 | 3.55 1.19 to 5.88 | 3.20 1.25 to 5.22 | 3.20 1.45 to 4.95 | 3.13 1.46 to 4.77 | 3.06 1.08 to 4.96 | 3.06 1.08 to 5.01 | 2.33 0.45 to 4.17 | 2.31 0.16 to 4.49 | 2.28 0.33 to 4.23 | 2.14 -0.48 to 4.83 | 1.99 0.15 to 3.82 | 1.96 -0.29 to 4.25 | 1.94 0.28 to 3.56 | 1.24 -0.96 to 3.50 | 1.09 -0.39 to 2.56 | 0.75 -2.24 to 3.72 | INS_DEGLUDEC | -0.12 -1.73 to 1.47 | -0.15 -2.46 to 2.11 | -0.36 -2.85 to 2.16 | -0.41 -2.45 to 1.67 | -0.57 -3.24 to 2.14 | -0.53 -2.73 to 1.82 | -1.19 -7.12 to 4.59 | -1.78 -4.02 to 0.49 |
| INS_GLARGINE | 2.18 1.46 to 2.88 | 16.02 11.88 to 20.31 | 11.75 9.13 to 14.38 | 11.33 7.14 to 15.53 | 6.64 5.58 to 7.69 | 5.20 3.46 to 6.93 | 4.87 -1.15 to 10.83 | 4.78 3.21 to 6.36 | 4.43 2.52 to 6.32 | 4.40 2.71 to 6.12 | 3.91 2.60 to 5.28 | 3.88 3.10 to 4.63 | 3.83 3.01 to 4.65 | 3.65 1.75 to 5.51 | 3.31 2.06 to 4.61 | 3.31 2.21 to 4.40 | 3.24 2.48 to 4.03 | 3.17 1.93 to 4.38 | 3.16 1.84 to 4.49 | 2.42 1.29 to 3.59 | 2.41 0.72 to 4.08 | 2.38 1.14 to 3.62 | 2.24 0.03 to 4.54 | 2.10 0.88 to 3.29 | 2.08 0.32 to 3.79 | 2.05 1.20 to 2.88 | 1.35 -0.23 to 2.96 | 1.20 0.16 to 2.26 | 0.87 -1.67 to 3.45 | 0.12 -1.47 to 1.73 | INS_GLARGINE | -0.04 -1.97 to 1.79 | -0.26 -2.25 to 1.82 | -0.30 -1.84 to 1.22 | -0.44 -2.76 to 1.84 | -0.45 -2.09 to 1.46 | -1.05 -6.77 to 4.57 | -1.66 -3.36 to 0.04 |
| OTHER_ACTIVE_sulfonylurea | 2.22 0.39 to 4.07 | 16.08 11.66 to 20.74 | 11.82 8.72 to 15.04 | 11.37 6.86 to 15.86 | 6.67 4.70 to 8.82 | 5.24 2.87 to 7.64 | 4.92 -1.35 to 11.14 | 4.82 2.44 to 7.22 | 4.49 2.04 to 6.95 | 4.44 2.11 to 6.80 | 3.97 1.80 to 6.19 | 3.92 2.25 to 5.62 | 3.86 1.94 to 5.76 | 3.69 1.22 to 6.13 | 3.36 1.15 to 5.59 | 3.34 1.40 to 5.34 | 3.28 1.43 to 5.23 | 3.21 1.05 to 5.37 | 3.20 1.04 to 5.35 | 2.46 0.44 to 4.61 | 2.44 0.11 to 4.86 | 2.43 0.24 to 4.58 | 2.29 -0.52 to 5.10 | 2.14 0.07 to 4.22 | 2.13 -0.32 to 4.59 | 2.09 0.33 to 3.91 | 1.39 -0.94 to 3.83 | 1.25 -0.75 to 3.28 | 0.92 -2.27 to 4.07 | 0.15 -2.11 to 2.46 | 0.04 -1.79 to 1.97 | OTHER_ACTIVE_sulfonylurea | -0.20 -2.83 to 2.41 | -0.25 -2.45 to 1.95 | -0.39 -3.30 to 2.42 | -0.40 -2.78 to 2.24 | -0.99 -6.95 to 4.84 | -1.63 -4.02 to 0.82 |
| INS_DETEMIR | 2.43 0.34 to 4.45 | 16.28 11.82 to 21.11 | 12.03 8.77 to 15.21 | 11.55 6.88 to 16.17 | 6.90 4.64 to 9.10 | 5.46 2.87 to 7.99 | 5.09 -1.12 to 11.29 | 5.05 2.41 to 7.59 | 4.69 2.01 to 7.36 | 4.65 2.07 to 7.20 | 4.17 1.81 to 6.49 | 4.13 2.08 to 6.16 | 4.07 1.99 to 6.15 | 3.90 1.16 to 6.60 | 3.56 1.18 to 5.90 | 3.56 1.30 to 5.79 | 3.50 1.61 to 5.37 | 3.43 1.06 to 5.68 | 3.42 1.03 to 5.74 | 2.68 0.43 to 4.91 | 2.67 0.06 to 5.17 | 2.64 0.30 to 4.90 | 2.49 -0.45 to 5.53 | 2.37 0.08 to 4.57 | 2.33 -0.29 to 4.85 | 2.31 0.24 to 4.33 | 1.60 -1.02 to 4.16 | 1.45 -0.82 to 3.65 | 1.13 -2.18 to 4.29 | 0.36 -2.16 to 2.85 | 0.26 -1.82 to 2.25 | 0.20 -2.41 to 2.83 | INS_DETEMIR | -0.04 -2.57 to 2.37 | -0.20 -3.14 to 2.75 | -0.18 -2.77 to 2.52 | -0.84 -6.79 to 5.23 | -1.40 -3.97 to 1.11 |
| GLIMEPIRIDE | 2.48 1.03 to 3.91 | 16.33 11.95 to 20.88 | 12.08 9.07 to 14.89 | 11.62 7.18 to 16.07 | 6.94 5.27 to 8.62 | 5.50 3.39 to 7.59 | 5.17 -0.91 to 11.20 | 5.08 2.95 to 7.18 | 4.75 2.43 to 7.05 | 4.70 2.62 to 6.82 | 4.23 2.32 to 6.13 | 4.18 2.74 to 5.64 | 4.12 2.59 to 5.66 | 3.97 1.67 to 6.21 | 3.61 1.76 to 5.50 | 3.60 2.09 to 5.17 | 3.54 2.00 to 5.11 | 3.47 1.56 to 5.31 | 3.48 1.50 to 5.36 | 2.72 1.00 to 4.50 | 2.71 0.63 to 4.79 | 2.70 0.78 to 4.54 | 2.54 -0.02 to 5.20 | 2.41 0.82 to 3.97 | 2.37 0.24 to 4.49 | 2.35 0.82 to 3.85 | 1.66 -0.47 to 3.82 | 1.51 -0.17 to 3.20 | 1.17 -1.71 to 4.19 | 0.41 -1.67 to 2.45 | 0.30 -1.22 to 1.84 | 0.25 -1.95 to 2.45 | 0.04 -2.37 to 2.57 | GLIMEPIRIDE | -0.14 -2.80 to 2.42 | -0.15 -2.21 to 2.26 | -0.77 -6.62 to 5.04 | -1.37 -3.52 to 0.83 |
| ROSIGLITAZONE | 2.63 0.32 to 4.88 | 16.48 11.77 to 21.32 | 12.21 8.79 to 15.58 | 11.76 7.03 to 16.47 | 7.09 4.63 to 9.56 | 5.66 2.93 to 8.45 | 5.34 -0.96 to 11.63 | 5.24 2.51 to 8.00 | 4.88 1.93 to 7.79 | 4.86 2.03 to 7.60 | 4.35 1.81 to 6.89 | 4.33 2.03 to 6.62 | 4.28 2.17 to 6.39 | 4.10 1.15 to 6.98 | 3.77 1.20 to 6.36 | 3.76 1.29 to 6.23 | 3.69 1.42 to 5.98 | 3.63 1.01 to 6.15 | 3.61 1.13 to 6.14 | 2.88 0.47 to 5.30 | 2.87 0.20 to 5.50 | 2.84 0.28 to 5.39 | 2.69 0.69 to 4.80 | 2.56 0.11 to 5.01 | 2.51 -0.24 to 5.30 | 2.49 0.16 to 4.81 | 1.80 -0.94 to 4.54 | 1.65 -0.75 to 4.05 | 1.33 -2.03 to 4.77 | 0.57 -2.14 to 3.24 | 0.44 -1.84 to 2.76 | 0.39 -2.42 to 3.30 | 0.20 -2.75 to 3.14 | 0.14 -2.42 to 2.80 | ROSIGLITAZONE | 0.01 -2.55 to 2.81 | -0.60 -6.62 to 5.59 | -1.22 -3.96 to 1.52 |
| INS_PREMIX | 2.63 0.76 to 4.21 | 16.45 12.03 to 21.01 | 12.17 9.05 to 15.24 | 11.73 7.28 to 16.17 | 7.09 5.02 to 8.96 | 5.63 3.18 to 7.90 | 5.30 -0.45 to 11.01 | 5.22 2.80 to 7.41 | 4.88 2.26 to 7.26 | 4.82 2.39 to 7.10 | 4.35 2.24 to 6.28 | 4.31 2.38 to 5.97 | 4.26 2.56 to 5.73 | 4.08 1.54 to 6.44 | 3.76 1.52 to 5.80 | 3.75 1.67 to 5.65 | 3.67 1.81 to 5.34 | 3.63 1.43 to 5.50 | 3.61 1.43 to 5.50 | 2.87 0.75 to 4.74 | 2.85 0.49 to 5.00 | 2.83 0.61 to 4.77 | 2.69 -0.07 to 5.28 | 2.55 0.40 to 4.46 | 2.54 0.02 to 4.72 | 2.49 0.54 to 4.17 | 1.81 -0.64 to 4.02 | 1.65 -0.46 to 3.52 | 1.31 -1.84 to 4.23 | 0.53 -1.82 to 2.73 | 0.45 -1.46 to 2.09 | 0.40 -2.24 to 2.78 | 0.18 -2.52 to 2.77 | 0.15 -2.26 to 2.21 | -0.01 -2.81 to 2.55 | INS_PREMIX | -0.64 -6.59 to 5.18 | -1.24 -3.68 to 1.02 |
| OTHER_ACTIVE_testosterone | 3.24 -2.42 to 8.89 | 17.12 10.30 to 24.08 | 12.83 6.63 to 19.14 | 12.36 5.51 to 19.30 | 7.70 2.14 to 13.20 | 6.26 0.44 to 12.18 | 6.01 -2.13 to 14.22 | 5.82 0.13 to 11.60 | 5.51 -0.40 to 11.51 | 5.44 -0.40 to 11.31 | 4.97 -0.78 to 10.70 | 4.92 -0.68 to 10.62 | 4.86 -0.77 to 10.56 | 4.66 -1.24 to 10.64 | 4.37 -1.46 to 10.11 | 4.35 -1.35 to 9.98 | 4.29 -1.34 to 10.00 | 4.23 -1.50 to 9.96 | 4.21 -1.48 to 9.99 | 3.46 -2.19 to 9.25 | 3.46 -2.46 to 9.30 | 3.44 -2.34 to 9.19 | 3.30 -2.75 to 9.43 | 3.16 -2.55 to 8.94 | 3.11 -2.69 to 9.00 | 3.11 -2.59 to 8.80 | 2.42 -3.49 to 8.34 | 2.28 -3.41 to 8.06 | 1.92 -4.37 to 8.18 | 1.19 -4.59 to 7.12 | 1.05 -4.57 to 6.77 | 0.99 -4.84 to 6.95 | 0.84 -5.23 to 6.79 | 0.77 -5.04 to 6.62 | 0.60 -5.59 to 6.62 | 0.64 -5.18 to 6.59 | OTHER_ACTIVE_testosterone | -0.61 -6.46 to 5.29 |
| PIOGLITAZONE | 3.85 2.14 to 5.52 | 17.70 13.34 to 22.24 | 13.45 10.34 to 16.46 | 13.02 8.53 to 17.36 | 8.32 6.43 to 10.22 | 6.86 4.54 to 9.12 | 6.52 0.33 to 12.62 | 6.43 4.24 to 8.71 | 6.11 3.76 to 8.44 | 6.06 3.78 to 8.31 | 5.59 3.58 to 7.60 | 5.54 3.80 to 7.23 | 5.49 3.77 to 7.19 | 5.31 2.90 to 7.71 | 4.98 2.93 to 7.05 | 4.97 3.11 to 6.85 | 4.91 3.29 to 6.57 | 4.84 2.80 to 6.82 | 4.82 2.80 to 6.83 | 4.09 2.18 to 5.97 | 4.08 1.77 to 6.35 | 4.07 1.97 to 6.05 | 3.92 1.19 to 6.71 | 3.77 1.79 to 5.70 | 3.74 1.41 to 6.06 | 3.71 2.09 to 5.34 | 3.05 0.75 to 5.31 | 2.87 0.95 to 4.78 | 2.52 -0.47 to 5.56 | 1.78 -0.49 to 4.02 | 1.66 -0.04 to 3.36 | 1.63 -0.82 to 4.02 | 1.40 -1.11 to 3.97 | 1.37 -0.83 to 3.52 | 1.22 -1.52 to 3.96 | 1.24 -1.02 to 3.68 | 0.61 -5.29 to 6.46 | PIOGLITAZONE |
Heterogeneity, fit and convergence
Bayesian random effects (primary)
Frequentist check (netmeta)
Inconsistency
Do trials comparing two treatments directly agree with the indirect evidence through other treatments?
No comparison here has both direct and indirect evidence, so inconsistency cannot be checked by node splitting; the between designs Q above is the global check.
Small study effects
A comparison adjusted funnel plot: each point is one trial comparison, centered on its own network estimate. Asymmetry can signal that small trials with unfavorable results are missing.
Fewer than ten trial comparisons, too few to judge funnel plot asymmetry.
Baseline characteristics of the trials
The baseline value of each effect modifier or prognostic factor that applies here, per trial: mean or percent over arms, weighted by the number randomized. A note under a value names a stand in (a median for a mean, 100 minus the male share, Asian subgroup rows, an all Asian site list); "not reported" means no source of the trial prints it.
| Trial | Baseline BMI or body weight (kg/m2) effect modifier, prognostic factor; 42 of 49 | Sex (percent female) effect modifier, prognostic factor; 45 of 49 | Background glucose lowering therapy (stratum S0 to S4) effect modifier, prognostic factor; 49 of 49 | Asian ancestry or region (percent Asian) effect modifier, prognostic factor; 35 of 49 | Kidney function (eGFR) (mL/min/1.73 m2) prognostic factor, effect modifier; 5 of 49 | Treatment duration (weeks) effect modifier; 49 of 49 | Lifestyle co-intervention intensity (none standard intensive) effect modifier, prognostic factor; 49 of 49 |
|---|---|---|---|---|---|---|---|
| NCT00754988 S000027 | 32.47 | 44.91 | S1 | 8.82 | not reported | 156 | none |
| SEMAT S000079 | 35.85 median | not reported | S1 | not reported | not reported | 24 | standard |
| NCT01296412 S000080 | 32.65 | 45 100 minus male share | S1 | not reported | not reported | 26 | standard |
| DUAL™ I China S000081 | 26.75 | 40.67 | S1 | 100 region: all sites in Asia | not reported | 26 | not_reported |
| DUAL™IV S000164 | 31.47 | 47.81 | S1 | 16.56 | not reported | 26 | standard |
| NCT03235050 S000257 | not reported | 53.72 | S1 | 0.72 | not reported | 54 | not_reported |
| NCT01029886 S000352 | 32.3 | 45.49 | S1 | 12 | not reported | 26 | not_reported |
| NCT00637273 S000402 | 32.33 | 48.02 | S1 | 24 | not reported | 26 | not_reported |
| NCT00717457 S000414 | 33.47 | 46.98 100 minus male share | S1 | not reported | not reported | 52 | not_reported |
| SUSTAIN 9 S000483 | 31.9 | 41.72 | S1 | 23.51 | 95.2 | 30 | not_reported |
| SUSTAIN 10 S000584 | body weight 96.9 kg | 43.33 | S1 | 1.39 | 92.4 | 30 | not_reported |
| NCT03951753 S000593 | 31.33 | 26.5 | S1 | 0 | not reported | 28 | not_reported |
| NCT00935532 S000632 | body weight 70.5 kg | 32.08 | S1 | 100 region: all sites in Asia | not reported | 26 | not_reported |
| NCT02008682 S000650 | 27.25 | 40.35 | S1 | 100 region: all sites in Asia | not reported | 26 | not_reported |
| NCT00577824 S000752 | 25.48 | 31.49 | S1 | 100 region: all sites in Asia | not reported | 24 | not_reported |
| NCT01149421 S000784 | 32.96 | 48.08 | S1 | 9.14 | eGFR below 60: 6.8 percent | 26 | not_reported |
| NCT00434954 S000790 | 33.15 | 30.36 | S1 | not reported | not reported | 26 | not_reported |
| EXENDA S000796 | 31.34 | 33.35 | S1 | not reported | not reported | 24 | not_reported |
| NCT00395746 S000862 | 24.87 | 36 | S1 | 100 region: all sites in Asia | not reported | 52 | not_reported |
| NCT00135330 S000943 | 32.5 | 48.91 | S1 | not reported | not reported | 20 | not_reported |
| LIRA-Ramadan™ S000963 | 30.8 | 50.75 | S1 | 45.14 | not reported | 30 | not_reported |
| D-LIFT S000993 | 29.75 | 30 | S1 | 100 | not reported | 24 | standard |
| LIRA-SWITCH™ S001119 | 31.95 | 40.5 | S1 | not reported | not reported | 26 | not_reported |
| DUAL™ VIII S001131 | not reported | 45.16 | S1 | 11.36 | not reported | 104 | not_reported |
| DURATION-NEO-2 S001157 | 31.83 | 47.12 | S1 | 3.85 | not reported | 28 | not_reported |
| NCT00701935 S001193 | not reported | 47.5 | S1 | not reported | not reported | 26.07 | not_reported |
| LixiLan-O S001199 | 31.72 | 49.44 | S1 | 1.54 | not reported | 30 | not_reported |
| SUSTAIN™ 4 S001219 | 33 | not reported | S1 | not reported | 96.1 | 30 | not_reported |
| NCT04504396 S001230 | 26.48 | 39.7 | S1 | 100 region: all sites in Asia | 104.98 | 24 | standard |
| NCT00877890 S001308 | body weight 95.7 kg | 42.13 | S1 | not reported | not reported | 24 | not_reported |
| NCT00360334 S001323 | 34.15 | 31.49 | S1 | not reported | not reported | 26 | not_reported |
| NCT01003184 S001355 | 33.7 | 32.88 | S1 | 4 | not reported | 26 | not_reported |
| AWARD-CHN2 S001404 | 26.77 | 44.77 | S1 | 81.52 | not reported | 52 | not_reported |
| NCT00917267 S001437 | 26.55 | not reported | S1 | 100 region: all sites in Asia | not reported | 26 | not_reported |
| LEAD-2 S001502 | 31 | 41.77 | S1 | 9 | not reported | 26 | not_reported |
| LIGHT-ON S001525 | 29.8 | 30.67 | S1 | 100 region: all sites in Asia | not reported | 26 | standard |
| GETGOAL-F1 S001563 | 32.53 | 55.59 | S1 | 7.45 | not reported | 24 | not_reported |
| NCT00603239 S001737 | not reported | 40.61 | S1 | not reported | not reported | 26 | not_reported |
| NCT00641056 S001768 | 32 | 45.61 | S1 | 6 | not reported | 84 | not_reported |
| LEAD-5 S002098 | 30.54 | 43.38 | S1 | not reported | not reported | 26 | not_reported |
| LEAD-6 S002230 | 32.9 | 48.06 | S1 | 0.86 | not reported | 26 | not_reported |
| NCT00700817 S002361 | 32.77 | 47.07 | S1 | 1.65 | not reported | 26 | not_reported |
| S002928 S002928 | 53.83 median | 32.37 | S1 | 100 region: all sites in Asia | not reported | 24 | standard |
| S002969 S002969 | 36.76 median | 77.78 | S1 | not reported | not reported | 26 | standard |
| S003004 S003004 | 26.97 | not reported | S1 | 100 region: all sites in Asia | not reported | 26.07 | not_reported |
| S003006 S003006 | 26.5 | 35 | S1 | 100 region: all sites in Asia | 76.55 | 24 | not_reported |
| S003044 S003044 | 23.74 | 43.16 | S1 | 100 region: all sites in Asia | not reported | 24 | standard |
| S003071 S003071 | 25.88 | 34.35 | S1 | 100 region: all sites in Asia | not reported | 24 | none |
| S003086 S003086 | 27.33 | 45.29 100 minus male share | S1 | 100 region: all sites in Asia | not reported | 24 | not_reported |
Comparability of the trials
Checked across designs (the set of treatments each trial compares) for eligibility, outcome definition and assessment, and the baseline factors above. Flags point to possible intransitivity; notes describe variation that is not tied to design.
- FlagBaseline, Baseline BMI or body weight: design means range from 24.9 (LIRA_SC_0p6MG_QD vs LIRA_SC_0p9MG_QD vs PLACEBO) to 53.8 (PEGLOX_SC_300UG_QW vs PEGLOX_SC_400UG_QW vs PLACEBO) kg/m2; threshold 3
- FlagBaseline, Sex: design means range from 26.5 (PLACEBO vs SEMA_SC_1p0MG_QW vs TIRZ_SC_15MG_QW) to 77.8 (LIRA_SC_1p8MG_QD vs PLACEBO) percent female; threshold 15
- FlagBaseline, Asian ancestry or region: not reported by 14 of 49 trials
- FlagBaseline, Asian ancestry or region: design means range from 0.0 (PLACEBO vs SEMA_SC_1p0MG_QW vs TIRZ_SC_15MG_QW) to 100.0 (BEIN_SC_FLEX_0p1-0p2_TID vs INS_PREMIX) percent Asian; threshold 30
- FlagBaseline, Kidney function (eGFR): not reported by 44 of 49 trials
- FlagBaseline, Kidney function (eGFR): design means range from 76.5 (INS_GLARGINE vs LIRA_SC_0p9MG_QD) to 105.0 (PLACEBO vs VISEPE_SC_150UG_QW) mL/min/1.73 m2; threshold 15
- FlagBaseline, Treatment duration: design means range from 20.0 (EXEN_SC_10UG_BID vs EXENROSI_SC_10-4UG_BID vs ROSIGLITAZONE) to 156.0 (PLACEBO vs SITAGLIPTIN vs TASP_SC_10MG_QW vs TASP_SC_20MG_QW) weeks; threshold 26
- FlagEligibility, bmi entry range: a design requires bmi 50 or more while another admits only 35 or less
- NoteOutcome assessment, time point: selected time points span 20 to 30 weeks
- NoteOutcome assessment, analysis set: mixed: completers 5, full_analysis 17, modified_itt 21, other 1, per_protocol 1, randomized 4
- NoteOutcome assessment, definition: mixed: Body weight at week 28, LS mean 1, change from baseline in HbA1c, LS mean ANCOVA, LOCF 1, HbA1c after 24 weeks 1, HbA1c change from baseline to endpoint, last observation on treatment carried forward 1, HbA1c change from baseline, ITT 1, LS mean body weight change baseline to week 24, ANCOVA 1, not stated 43
- NoteRisk of bias, blinding: mixed: double_blind 19, not_reported 2, open_label 27, single_blind 1
- NoteRisk of bias, funding: mixed: industry 40, mixed 2, non_industry 7
- NoteData handling, input conversions: arms_combined 1, median_converted 4, n_randomized 2
| Trial | time weeks | analysis set | definition | instrument | adjudicated | proportion method | intercurrent events (discontinuation) | intercurrent events (rescue) | blinding | funding | start year | Eligibility |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT00754988 | 24 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2008 | age 18 to 75; HbA1c 7.0 to 10.0 percent; BMI 25 (23 Asian) to 45; metformin at least 1500 mg |
| SEMAT | 24 | randomized | not stated | not stated | not stated | not stated | not stated | not stated | open_label | non_industry | 2020 | men 18 to 65; type 2 diabetes on oral agents; BMI above 30; functional hypogonadism with testosterone below 11 nmol/L |
| NCT01296412 | 26 | completers | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2011 | age 18 to 79; HbA1c 7.0 to 11.0 percent on metformin 1500 mg or more; eGFR 60 or more |
| DUAL™ I China | 26 | full_analysis | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2017 | Chinese adults 18 y or older; HbA1c 7.0 to 10.0; BMI 40 or less; metformin with or without one OAD |
| DUAL™IV | 26 | full_analysis | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2012 | adults 18 or older; HbA1c 7.0 to 9.0 percent; BMI 40 or less; SU with or without metformin; insulin and GLP-1 RA naive |
| NCT03235050 | 26 | full_analysis | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2017 | age 18 or older; BMI 25 or higher; HbA1c 7.0 to 10.5 percent; on metformin |
| NCT01029886 | 26 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2010 | adults 18 or older with type 2 diabetes on oral agents, HbA1c 7.1 to 11.0 percent, BMI 45 or less |
| NCT00637273 | 26 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2008 | age 18 or older; HbA1c 7.1 to 11.0 percent; BMI 25 to 45; stable metformin |
| NCT00717457 | 24 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2008 | age 18 to 75; HbA1c 7 to 10 percent; BMI 25 to 45 (above 23 for Asians); metformin with or without TZD |
| SUSTAIN 9 | 30 | full_analysis | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2017 | adults 18 or older (20 in Japan); HbA1c 7.0 to 10.5 percent; stable SGLT2i with or without metformin or SU |
| SUSTAIN 10 | 30 | full_analysis | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2017 | adults with T2D, HbA1c 7.0 to 11.0 percent on 1 to 3 oral drugs |
| NCT03951753 | 28 | modified_itt | Body weight at week 28, LS mean | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2019 | age 20 to 74; BMI 25 to 45; metformin with or without one other oral agent |
| NCT00935532 | 26 | full_analysis | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2009 | type 2 diabetes on biguanide with or without thiazolidinedione |
| NCT02008682 | 26 | full_analysis | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2013 | Chinese adults 18 to 80; HbA1c 7.0 to 10.0 on metformin; BMI 45 or lower |
| NCT00577824 | 24 | full_analysis | HbA1c change from baseline to endpoint, last observation on treatment carried forward | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2008 | age 20 to 75; HbA1c 7.0 to 10.0 percent JDS; weight 50 kg or more; sulfonylurea based oral therapy |
| NCT01149421 | 26 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2010 | adults 18 or older; HbA1c 7 to 9.5 percent; stable oral agents |
| NCT00434954 | 26 | full_analysis | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2007 | adults with T2D on metformin, HbA1c 6.5 to 10.0 percent |
| EXENDA | 24 | randomized | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2017 | age 18 to 75; BMI 25 or more; HbA1c 6.5 to 11 percent; metformin 1000 mg or more |
| NCT00395746 | 24 | full_analysis | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2006 | age 20 or older; HbA1c 7.4 to 10.4 on one sulfonylurea |
| NCT00135330 | 20 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2005 | age 18 to 75; BMI 25 to 40; HbA1c 6.8 to 10.0 percent; stable metformin only |
| LIRA-Ramadan™ | 26 | full_analysis | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2014 | age 18 to 80; HbA1c 7 to 10 percent; BMI 20 or more; metformin plus sulfonylurea; intent to fast in Ramadan |
| D-LIFT | 24 | per_protocol | not stated | not stated | not stated | not stated | not stated | not stated | open_label | non_industry | 2019 | age over 20; type 2 diabetes HbA1c 7.0 to 10.0; MRI-PDFF liver fat 6 percent or more |
| LIRA-SWITCH™ | 26 | full_analysis | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2013 | age 18 or more; HbA1c 7.5 to 9.5 percent; BMI 20 or more; on sitagliptin 100 mg and metformin for 90 days or more |
| DUAL™ VIII | 26 | full_analysis | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2016 | adults with type 2 diabetes uncontrolled on oral drugs, insulin naive |
| DURATION-NEO-2 | 28 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2013 | age 18 or older; HbA1c 7.1 to 11.0 percent; BMI 45 or lower; metformin 1500 mg or more |
| NCT00701935 | 26.07 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2008 | adults with T2D on metformin |
| LixiLan-O | 30 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2014 | adults; HbA1c 7.5 to 10% on metformin or 7 to 9% on metformin plus second OAD; 7 to 10% after run in |
| SUSTAIN™ 4 | 30 | full_analysis | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2014 | adults with T2D, insulin naive, on metformin with or without SU; HbA1c 7.0 to 10.0 percent |
| NCT04504396 | 24 | full_analysis | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2020 | age 18 to 75; HbA1c 7.0 to 10.5 percent; BMI 40 or lower; eGFR 60 or higher; metformin monotherapy at least 1000 mg |
| NCT00877890 | 24 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2009 | age 18 or older; HbA1c 7.1 to 11.0 percent; BMI 25 to 45 |
| NCT00360334 | 26 | full_analysis | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2006 | BMI above 27; HbA1c 7.5 to 10.0 percent; 2 or 3 oral drugs; at least one CV risk factor |
| NCT01003184 | 26 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2009 | age 18 or older; HbA1c 7.1 to 10.0 percent; BMI 25 to 45; metformin with or without SU |
| AWARD-CHN2 | 26 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2012 | age 18 or older; BMI 19 to 35 kg/m2; HbA1c 7.0 to 11.0 percent on metformin and/or sulfonylurea |
| NCT00917267 | 26 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2009 | Asian adults 20 or older; HbA1c 7 to 11; BMI 21 to 35; on oral drugs |
| LEAD-2 | 26 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2006 | age 18 to 80; HbA1c 7 to 11 percent on one OAD or 7 to 10 on combination; BMI 40 or less; no recent insulin |
| LIGHT-ON | 26 | randomized | not stated | not stated | not stated | not stated | not stated | not stated | open_label | mixed | 2014 | age 30 to 75, HbA1c 6.5 to 10 percent on metformin, NAFLD with MRI-PDFF over 10 percent, BMI 20 to 35 |
| GETGOAL-F1 | 24 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2008 | adults with T2D on metformin |
| NCT00603239 | 26 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2008 | type 2 diabetes on a thiazolidinedione with or without metformin |
| NCT00641056 | 26 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2008 | age 18 or older; HbA1c 7.1 to 11.0 percent; BMI 25 to 45; metformin with or without sulfonylurea |
| LEAD-5 | 26 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2006 | age 18 to 80; HbA1c 7.5 to 10 on monotherapy or 7 to 10 on combination; BMI 45 or lower |
| LEAD-6 | 26 | modified_itt | change from baseline in HbA1c, LS mean ANCOVA, LOCF | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2007 | age 18 to 80; HbA1c 7.0 to 11.0 percent; BMI 45 or less; stable metformin, sulfonylurea or both |
| NCT00700817 | 26 | full_analysis | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2008 | age 18 to 80; HbA1c 7.5 to 10%; BMI 45 or less; metformin 1500 mg/day or more for 3 months |
| S002928 | 24 | completers | LS mean body weight change baseline to week 24, ANCOVA | not stated | not stated | not stated | not stated | not stated | single_blind | non_industry | 2022 | age 18 to 65; BMI 50 or more; type 2 diabetes |
| S002969 | 26.07 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2018 | age 18 to 70; BMI 30 to 50; HbA1c 48 to below 97 mmol/mol; T2DM under 10 years; undergoing LAGB |
| S003004 | 26.07 | completers | not stated | not stated | not stated | not stated | not stated | not stated | not_reported | non_industry | 2020 | age 18 to 65; BMI 22 to 40; HbA1c 7 to 10 percent on metformin alone |
| S003006 | 24 | completers | not stated | not stated | not stated | not stated | not stated | not stated | open_label | non_industry | 2013 | Japanese adults 20 or older; HbA1c 7.0 to below 10 on DPP-4 inhibitor based oral therapy |
| S003044 | 24 | completers | HbA1c after 24 weeks | not stated | not stated | not stated | not stated | not stated | not_reported | mixed | 2015 | HbA1c 7.0 to <10.0%; BMI 18.5 to <25; waist >85 cm men, >80 cm women; stable oral agents |
| S003071 | 24 | other | not stated | not stated | not stated | not stated | not stated | not stated | open_label | non_industry | 2010 | age 18 to under 80; HbA1c 6.9 to 9.4 percent NGSP; BMI 35 or less; on sulfonylurea |
| S003086 | 24 | randomized | HbA1c change from baseline, ITT | not stated | not stated | not stated | not stated | not stated | double_blind | non_industry | 2017 | age 18 to 65; HbA1c 6.5 percent or more; BMI 24 or more; SBP 90 to 130 mmHg |
Trial data
What each trial contributes. Arm rows give the arm value with its standard error, or events over participants; contrast rows give the mean difference on the analysis scale against the trial's first row. Flags mark converted, combined or approximated inputs.
| Trial | Arm | Treatment | Week | Data | Value | SE | Events / N | Flags | Source |
|---|---|---|---|---|---|---|---|---|---|
| NCT00754988 | A1 | PLACEBO | 24 | arm, change | -0.500 | 0.400 | 90 | R0022521:Results | |
| NCT00754988 | A2 | TASP_SC_10MG_QW | 24 | arm, change | -1.800 | 0.300 | 182 | R0022521:Results | |
| NCT00754988 | A3 | TASP_SC_20MG_QW | 24 | arm, change | -2.600 | 0.300 | 187 | R0022521:Results | |
| NCT00754988 | A4 | SITAGLIPTIN | 24 | arm, change | -0.900 | 0.300 | 177 | R0022521:Results | |
| SEMAT | A1 | SEMA_SC_1p0MG_QW | 24 | arm, change | -7.667 | 2.671 | 13 | median_converted | R0019948:Table 1 |
| SEMAT | A2 | OTHER_ACTIVE_testosterone | 24 | arm, change | 0.267 | 0.919 | 12 | median_converted | R0019948:Table 1 |
| NCT01296412 | A1 | SITAGLIPTIN | 26 | arm, change | -0.400 | 0.204 | 285 | R0026295:Table 4 | |
| NCT01296412 | A2 | LIRA_SC_FLEX_1p2-1p8_QD | 26 | arm, change | -2.800 | 0.230 | 262 | R0026295:Table 4 | |
| DUAL™ I China | A1 | IDEGLIRA_SC_TIT_QD | 26 | arm, change | 0.200 | 0.146 | 341 | registry:outcomes | |
| DUAL™ I China | A2 | INS_DEGLUDEC | 26 | arm, change | 1.300 | 0.209 | 167 | registry:outcomes | |
| DUAL™ I China | A3 | LIRA_SC_1p8MG_QD | 26 | arm, change | -2.500 | 0.220 | 151 | registry:outcomes | |
| DUAL™IV | A1 | IDEGLIRA_SC_TIT_QD | 26 | arm, change | 0.500 | 0.182 | 289 | registry:outcomes | |
| DUAL™IV | A2 | PLACEBO | 26 | arm, change | -1.000 | 0.215 | 146 | registry:outcomes | |
| NCT03235050 | A1 | PLACEBO | 26 | arm, change | -1.200 | 0.439 | 112 | registry:outcomes | |
| NCT03235050 | A2 | LIRA_SC_1p8MG_QD | 26 | arm, change | -3.900 | 0.444 | 110 | registry:outcomes | |
| NCT03235050 | A3 | COTA_SC_100UG_QD | 26 | arm, change | -3.200 | 0.472 | 100 | registry:outcomes | |
| NCT03235050 | A4 | COTA_SC_200UG_QD | 26 | arm, change | -3.940 | 0.293 | 256 | registry:outcomes | |
| NCT03235050 | A5 | COTA_SC_300UG_QD | 26 | arm, change | -4.750 | 0.293 | 256 | registry:outcomes | |
| NCT01029886 | A1 | EXENER_SC_2MG_QW | 26 | arm, change | -2.680 | 0.180 | 404 | R0016299:Table 2 | |
| NCT01029886 | A2 | LIRA_SC_1p8MG_QD | 26 | arm, change | -3.570 | 0.180 | 398 | R0016299:Table 2 | |
| NCT00637273 | A1 | EXENER_SC_2MG_QW | 26 | arm, change | -2.310 | 0.323 | 160 | registry:outcomes | |
| NCT00637273 | A2 | SITAGLIPTIN | 26 | arm, change | -0.770 | 0.322 | 163 | registry:outcomes | |
| NCT00637273 | A3 | PIOGLITAZONE | 26 | arm, change | 2.790 | 0.320 | 165 | registry:outcomes | |
| NCT00717457 | A1 | TASP_SC_10MG_QW | 24 | arm, change | -1.600 | 0.400 | 384 | R0013639:Results | |
| NCT00717457 | A2 | TASP_SC_20MG_QW | 24 | arm, change | -2.300 | 0.400 | 392 | R0013639:Results | |
| NCT00717457 | A3 | EXEN_SC_10UG_BID | 24 | arm, change | -2.300 | 0.400 | 373 | R0013639:Results | |
| SUSTAIN 9 | A1 | SEMA_SC_1p0MG_QW | 30 | arm, change | -4.700 | 0.350 | 151 | registry:outcomes | |
| SUSTAIN 9 | A2 | PLACEBO | 30 | arm, change | -1.000 | 0.252 | 151 | registry:outcomes | |
| SUSTAIN 10 | A1 | SEMA_SC_1p0MG_QW | 30 | arm, change | -5.800 | 0.276 | 290 | registry:outcomes | |
| SUSTAIN 10 | A2 | LIRA_SC_1p2MG_QD | 30 | arm, change | -2.000 | 0.242 | 287 | registry:outcomes | |
| NCT03951753 | A1 | TIRZ_SC_15MG_QW | 28 | arm, final | 83.400 | 0.860 | 41 | R0014677:Figure 1 | |
| NCT03951753 | A2 | SEMA_SC_1p0MG_QW | 28 | arm, final | 87.700 | 0.860 | 43 | R0014677:Figure 1 | |
| NCT03951753 | A3 | PLACEBO | 28 | arm, final | 94.600 | 1.100 | 24 | R0014677:Figure 1 | |
| NCT00935532 | A1 | EXENER_SC_2MG_QW | 26 | arm, change | -1.670 | 0.170 | 214 | registry:outcomes | |
| NCT00935532 | A2 | INS_GLARGINE | 26 | arm, change | 0.340 | 0.170 | 212 | registry:outcomes | |
| NCT02008682 | A1 | LIRA_SC_1p8MG_QD | 26 | contrast, md | -2.100 | 0.339 | R0025836:Results | ||
| NCT02008682 | A2 | SITAGLIPTIN | 26 | contrast, md | R0025836:Results | ||||
| NCT00577824 | A1 | PLACEBO | 24 | arm, change | -0.470 | 0.390 | 35 | R0018881:Results | |
| NCT00577824 | A2 | EXEN_SC_5UG_BID | 24 | arm, change | -0.390 | 0.280 | 71 | R0018881:Results | |
| NCT00577824 | A3 | EXEN_SC_10UG_BID | 24 | arm, change | -1.540 | 0.270 | 72 | R0018881:Results | |
| NCT01149421 | A1 | DULA_SC_1p5MG_QW | 26 | arm, change | -1.850 | 0.230 | 251 | registry:outcomes | |
| NCT01149421 | A2 | DULA_SC_0p75MG_QW | 26 | arm, change | -0.860 | 0.220 | 254 | registry:outcomes | |
| NCT01149421 | A3 | PLACEBO | 26 | arm, change | -0.080 | 0.220 | 250 | registry:outcomes | |
| NCT00434954 | A1 | EXEN_SC_10UG_BID | 26 | arm, change | -4.100 | 0.220 | 181 | registry:outcomes | |
| NCT00434954 | A2 | INS_PREMIX | 26 | arm, change | 1.020 | 0.220 | 173 | registry:outcomes | |
| EXENDA | A1 | EXENER_SC_2MG_QW | 24 | arm, change | -7.340 | 1.288 | 16 | R0025594:Table 3 | |
| EXENDA | A2 | PLACEBO | 24 | arm, change | -4.570 | 1.421 | 14 | R0025594:Table 3 | |
| NCT00395746 | A1 | LIRA_SC_0p6MG_QD | 24 | arm, final | 65.770 | 0.230 | 87 | registry:outcomes | |
| NCT00395746 | A2 | LIRA_SC_0p9MG_QD | 24 | arm, final | 65.340 | 0.240 | 87 | registry:outcomes | |
| NCT00395746 | A3 | PLACEBO | 24 | arm, final | 64.590 | 0.230 | 88 | registry:outcomes | |
| NCT00135330 | A1 | EXEN_SC_10UG_BID | 20 | arm, change | -2.800 | 0.500 | 45 | R0027805:Table 1 | |
| NCT00135330 | A2 | EXENROSI_SC_10-4UG_BID | 20 | arm, change | -1.200 | 0.500 | 47 | R0027805:Table 1 | |
| NCT00135330 | A3 | ROSIGLITAZONE | 20 | arm, change | 1.500 | 0.500 | 45 | R0027805:Table 1 | |
| LIRA-Ramadan™ | A1 | LIRA_SC_1p8MG_QD | 26 | arm, change | -5.400 | 0.221 | 165 | registry:outcomes | |
| LIRA-Ramadan™ | A2 | OTHER_ACTIVE_sulfonylurea | 26 | arm, change | -1.460 | 0.214 | 168 | registry:outcomes | |
| D-LIFT | A1 | STANDARD_CARE | 24 | arm, change | -2.000 | 0.700 | 25 | R0016566:Table 3 | |
| D-LIFT | A2 | DULA_SC_1p5MG_QW | 24 | arm, change | -4.300 | 0.500 | 27 | R0016566:Table 3 | |
| LIRA-SWITCH™ | A1 | LIRA_SC_1p8MG_QD | 26 | arm, change | -3.320 | 0.226 | 192 | registry:outcomes | |
| LIRA-SWITCH™ | A2 | SITAGLIPTIN | 26 | arm, change | -1.800 | 0.210 | 200 | registry:outcomes | |
| DUAL™ VIII | A1 | IDEGLIRA_SC_TIT_QD | 26 | arm, change | 0.500 | 0.147 | 506 | registry:outcomes | |
| DUAL™ VIII | A2 | INS_GLARGINE | 26 | arm, change | 2.200 | 0.160 | 506 | registry:outcomes | |
| DURATION-NEO-2 | A1 | EXENER_SC_2MG_QW | 28 | arm, change | -1.100 | 0.300 | 181 | R0010641:Table 2 | |
| DURATION-NEO-2 | A2 | SITAGLIPTIN | 28 | arm, change | -1.200 | 0.300 | 122 | R0010641:Table 2 | |
| DURATION-NEO-2 | A3 | PLACEBO | 28 | arm, change | 0.200 | 0.500 | 61 | R0010641:Table 2 | |
| NCT00701935 | A1 | EXEN_SC_10UG_BID | 26.07 | arm, change | -2.540 | 0.570 | 42 | registry:outcomes | |
| NCT00701935 | A2 | PLACEBO | 26.07 | arm, change | -0.330 | 0.720 | 33 | registry:outcomes | |
| LixiLan-O | A1 | IGLARLIXI2_SC_TIT_QD | 30 | arm, change | -0.300 | 0.200 | 467 | R0013783:Supplement Table S2 | |
| LixiLan-O | A2 | INS_GLARGINE | 30 | arm, change | 1.100 | 0.200 | 465 | R0013783:Supplement Table S2 | |
| LixiLan-O | A3 | LIXI_SC_20UG_QD | 30 | arm, change | -2.300 | 0.300 | 233 | R0013783:Supplement Table S2 | |
| SUSTAIN™ 4 | A1 | SEMA_SC_0p5MG_QW | 30 | arm, change | -3.470 | 0.240 | 362 | registry:outcomes | |
| SUSTAIN™ 4 | A2 | SEMA_SC_1p0MG_QW | 30 | arm, change | -5.170 | 0.240 | 360 | registry:outcomes | |
| SUSTAIN™ 4 | A3 | INS_GLARGINE | 30 | arm, change | 1.150 | 0.230 | 360 | registry:outcomes | |
| NCT04504396 | A1 | VISEPE_SC_150UG_QW | 24 | arm, change | -0.560 | 0.149 | 310 | R0009432:Results | |
| NCT04504396 | A2 | PLACEBO | 24 | arm, change | -0.670 | 0.139 | 310 | R0009432:Results | |
| NCT00877890 | A1 | EXENER_SC_2MG_QW | 24 | arm, change | -2.330 | 0.369 | 128 | registry:outcomes | |
| NCT00877890 | A2 | EXEN_SC_10UG_BID | 24 | arm, change | -1.370 | 0.386 | 120 | registry:outcomes | |
| NCT00360334 | A1 | EXEN_SC_10UG_BID | 26 | arm, change | -2.730 | 0.310 | 100 | R0024925:Table 2 | |
| NCT00360334 | A2 | INS_GLARGINE | 26 | arm, change | 2.980 | 0.310 | 104 | R0024925:Table 2 | |
| NCT01003184 | A1 | EXENER_SC_2MG_QW | 26 | arm, change | -2.700 | 0.300 | 111 | R0027663:Table 1 | |
| NCT01003184 | A2 | INS_DETEMIR | 26 | arm, change | 0.800 | 0.400 | 105 | R0027663:Table 1 | |
| AWARD-CHN2 | A1 | DULA_SC_1p5MG_QW | 26 | arm, change | -1.470 | 0.197 | 258 | R0023722:Results | |
| AWARD-CHN2 | A2 | DULA_SC_0p75MG_QW | 26 | arm, change | -0.880 | 0.197 | 257 | R0023722:Results | |
| AWARD-CHN2 | A3 | INS_GLARGINE | 26 | arm, change | 0.970 | 0.197 | 253 | R0023722:Results | |
| NCT00917267 | A1 | EXENER_SC_2MG_QW | 26 | arm, change | -1.630 | 0.160 | 309 | registry:outcomes | |
| NCT00917267 | A2 | EXEN_SC_10UG_BID | 26 | arm, change | -2.450 | 0.160 | 265 | registry:outcomes | |
| LEAD-2 | A1 | LIRA_SC_0p6MG_QD | 26 | arm, change | -1.800 | 0.200 | 242 | R0019848:Results | |
| LEAD-2 | A2 | LIRA_SC_1p2MG_QD | 26 | arm, change | -2.600 | 0.200 | 236 | R0019848:Results | |
| LEAD-2 | A3 | LIRA_SC_1p8MG_QD | 26 | arm, change | -2.800 | 0.200 | 241 | R0019848:Results | |
| LEAD-2 | A4 | GLIMEPIRIDE | 26 | arm, change | 1.000 | 0.200 | 237 | R0019848:Results | |
| LEAD-2 | A5 | PLACEBO | 26 | arm, change | -1.500 | 0.300 | 121 | R0019848:Results | |
| LIGHT-ON | A1 | LIRA_SC_1p8MG_QD | 26 | arm, change | -3.600 | 1.000 | 24 | R0024860:Table 2 | |
| LIGHT-ON | A2 | SITAGLIPTIN | 26 | arm, change | -1.700 | 0.558 | 27 | R0024860:Table 2 | |
| LIGHT-ON | A3 | INS_GLARGINE | 26 | arm, change | -1.200 | 0.857 | 24 | R0024860:Table 2 | |
| GETGOAL-F1 | A1 | PLACEBO | 24 | arm, change | -1.630 | 0.385 | 158 | registry:outcomes | |
| GETGOAL-F1 | A2+A3 | LIXI_SC_20UG_QD | 24 | arm, change | -2.655 | 0.273 | 313 | arms_combined | registry:outcomes |
| NCT00603239 | A1 | EXEN_SC_10UG_BID | 26 | arm, change | -1.430 | 0.610 | 111 | registry:outcomes | |
| NCT00603239 | A2 | PLACEBO | 26 | arm, change | -0.750 | 0.700 | 54 | registry:outcomes | |
| NCT00641056 | A1 | EXENER_SC_2MG_QW | 26 | arm, change | -2.630 | 0.200 | 207 | registry:outcomes | |
| NCT00641056 | A2 | INS_GLARGINE | 26 | arm, change | 1.420 | 0.200 | 209 | registry:outcomes | |
| LEAD-5 | A1 | LIRA_SC_1p8MG_QD | 26 | arm, change | -1.800 | 0.330 | 230 | R0027336:Results | |
| LEAD-5 | A2 | PLACEBO | 26 | arm, change | -0.420 | 0.390 | 114 | R0027336:Results | |
| LEAD-5 | A3 | INS_GLARGINE | 26 | arm, change | 1.600 | 0.330 | 232 | R0027336:Results | |
| LEAD-6 | A1 | LIRA_SC_1p8MG_QD | 26 | arm, change | -3.240 | 0.330 | 231 | registry:outcomes | |
| LEAD-6 | A2 | EXEN_SC_10UG_BID | 26 | arm, change | -2.870 | 0.330 | 229 | registry:outcomes | |
| NCT00700817 | A1 | LIRA_SC_1p2MG_QD | 26 | arm, change | -2.860 | 0.270 | 215 | registry:outcomes | |
| NCT00700817 | A2 | LIRA_SC_1p8MG_QD | 26 | arm, change | -3.380 | 0.270 | 214 | registry:outcomes | |
| NCT00700817 | A3 | SITAGLIPTIN | 26 | arm, change | -0.960 | 0.270 | 215 | registry:outcomes | |
| S002928 | A1 | PLACEBO | 24 | arm, change | -6.750 | 1.408 | 35 | R0007034:Table 2 | |
| S002928 | A2 | PEGLOX_SC_300UG_QW | 24 | arm, change | -16.340 | 1.408 | 35 | R0007034:Table 2 | |
| S002928 | A3 | PEGLOX_SC_400UG_QW | 24 | arm, change | -21.140 | 1.411 | 35 | R0007034:Table 2 | |
| S002969 | A1 | LIRA_SC_1p8MG_QD | 26.07 | arm, change | -2.767 | 2.031 | 12 | median_converted | R0010852:Table 2 |
| S002969 | A2 | PLACEBO | 26.07 | arm, change | -3.033 | 2.835 | 13 | median_converted | R0010852:Table 2 |
| S003004 | A1 | BEIN_SC_FLEX_0p1-0p2_TID | 26.07 | arm, final | 79.300 | 1.846 | 49 | R0016204:Table 2 | |
| S003004 | A2 | INS_PREMIX | 26.07 | arm, final | 85.390 | 2.210 | 52 | R0016204:Table 2 | |
| S003006 | A1 | INS_GLARGINE | 24 | arm, change | 0.500 | 0.510 | 26 | R0010916:Results | |
| S003006 | A2 | LIRA_SC_0p9MG_QD | 24 | arm, change | -2.200 | 0.371 | 29 | R0010916:Results | |
| S003044 | A1 | EXEN_SC_10UG_BID | 24 | arm, final | 64.530 | 1.646 | 40 | R0023353:Table 2 | |
| S003044 | A2 | INS_PREMIX | 24 | arm, final | 62.240 | 1.099 | 41 | R0023353:Table 2 | |
| S003071 | A1 | LIRA_SC_0p9MG_QD | 24 | arm, change | -0.600 | 0.407 | 36 | R0023696:Table 3 | |
| S003071 | A2 | SITAGLIPTIN | 24 | arm, change | 0.290 | 0.333 | 38 | R0023696:Table 3 | |
| S003086 | A1 | EXEN_SC_10UG_BID | 24 | arm, change | -5.388 | 0.938 | 79 | n_randomized | R0019483:Table 2 |
| S003086 | A2 | INS_GLARGINE | 24 | arm, change | -0.658 | 0.661 | 80 | n_randomized | R0019483:Table 2 |
Rerun this analysis yourself
Remove treatments or trials and refit the frequentist and Bayesian models in your browser, with the same methods as the published analysis.