parallel randomized trial

S003075

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

Overweight or obesity without diabetes (adults)S003075

Design

Randomized: 52
Start year: 2011
Treatment: 52 weeks, follow-up 52 weeks
Countries: Denmark (1 sites)
Sponsor: (mixed)
Eligibility: age 18 to 65; BMI 30 to 40; healthy; fasting glucose below 7 mmol/L

Conduct and analysis

Blinding: single blind
Sequence generation: not reported
Allocation concealment: not reported
Outcome adjudication: not reported
Primary estimand: not stated
Analysis population
Missing data

Arms

Arm	Treatment	Background	Randomized	Analyzed	Completed treatment
A1	Liraglutide 1.2 mg subcutaneous once daily GLP-1RA liraglutide 1.2 mg	weight maintenance diet program; lifestyle: intensive	27
A2	Standard care or no added treatment Control	weight maintenance diet program; lifestyle: intensive	25

Baseline characteristics

As printed in the trial reports or registry, per arm or for the whole trial.

Characteristic	Statistic	Liraglutide 1.2 mg subcutaneous once daily A1	Standard care or no added treatment A2
age	mean (years)	46	45
age	se (years)	2	2
bmi	mean (kg/m2)	30.8	29.7
bmi	se (kg/m2)	0.7	0.7
female	n	22	22
sbp	mean (mmHg)	114	116
sbp	se (mmHg)	2	3
waist	mean (cm)	98	98
waist	se (cm)	2	2
weight	mean (kg)	86.5	84.8
weight	se (kg)	1.5	1.8

Analyses this trial contributes to

Results

5 adjudicated result lines, grouped by outcome. Open an outcome to see its values.

Systolic blood pressure change (3 lines; O05)

Week	Arm	Statistic	Estimate	95% CI	Detail
52	A1	change	9.9 mmHg	3.9 to 16.0	not stated; other; R0018258:Results
52	A1 vs A2	md	2.7 mmHg	-5 to 10	not stated; other; R0018258:Results
52	A2	change	7.2 mmHg	2.2 to 12.3	not stated; other; R0018258:Results

Nausea (2 lines; O27A)

Week	Arm	Statistic	Estimate	SE or SD	95% CI	Events / N	Detail
	A1	events	40			27	not stated; other; R0018258:Results
	A2	events	4			25	not stated; other; R0018258:Results