Network meta-analysis

Level 2 or 3 hypoglycemia (participants)

Type 2 diabetes (adults)

longest follow-upRecorded harmsEach dose separatelyHazard ratio (from event counts)

Randomized trials

Treatments

41,671

Participants

3,984

Events

In plain language

Across 75 trials with 41,671 participants, 1 of 59 treatments had a clearly better result than placebo on level 2 or 3 hypoglycemia (participants), 6 a clearly worse one, and for 52 the evidence could not tell them apart from placebo. The most favorable estimate was for Polyethylene glycol loxenatide 0.3 mg injection once weekly: hazard ratio (from event counts) 0.12 (95% credible interval 0.00 to 3.36).

Lower values favor the treatment. "Clearly" means the 95% credible interval excludes no difference. These are averages across trials; they do not say how any one person will respond. Not medical advice.

Network of trials

Each circle is a treatment; each line joins treatments that were randomized against each other in at least one trial.

Node area shows participants; line width shows trials comparing two treatments directly. Blue: GLP-1 receptor agonist containing treatments; grey: comparators. Hover over or tab to a node or line for details.

Effects compared with Placebo

Hazard ratio (from event counts). Lower values favor the treatment.

Versus Placebo, log scale. Blue: Bayesian random effects posterior median with 95% credible interval (thick) and 95% prediction interval (dashed). Amber diamond: frequentist estimate with 95% confidence interval. Hover over or tab to a row for its values.

Effects of each treatment versus Placebo
Treatment	Bayesian HR (95% CrI)	95% prediction interval	Verdict
Polyethylene glycol loxenatide 0.3 mg injection once weekly PEGLOX_SC_0p3MG_QW	0.12 (0.00 to 3.36)	0.00 to 4.01	Unclear
Dulaglutide 3.0 mg subcutaneous once weekly DULA_SC_3p0MG_QW	0.15 (0.02 to 0.92)	0.01 to 1.29	Better
Semaglutide 16 mg injection once weekly SEMA_SC_16MG_QW	0.21 (0.00 to 5.65)	0.00 to 6.75	Unclear
Semaglutide 8 mg injection once weekly SEMA_SC_8MG_QW	0.21 (0.00 to 5.35)	0.00 to 6.49	Unclear
Pioglitazone PIOGLITAZONE	0.21 (0.02 to 1.27)	0.01 to 1.84	Unclear
Mazdutide 4.5 mg subcutaneous once weekly MAZD_SC_4p5MG_QW	0.23 (0.00 to 5.39)	0.00 to 6.78	Unclear
Mazdutide 3 mg subcutaneous once weekly MAZD_SC_3MG_QW	0.24 (0.00 to 7.04)	0.00 to 7.64	Unclear
Standard care or no added treatment STANDARD_CARE	0.28 (0.02 to 2.06)	0.02 to 2.77	Unclear
Dulaglutide 0.75 mg subcutaneous once weekly DULA_SC_0p75MG_QW	0.36 (0.08 to 1.27)	0.06 to 2.02	Unclear
Tirzepatide 10 mg subcutaneous once weekly TIRZ_SC_10MG_QW	0.43 (0.14 to 1.24)	0.09 to 2.09	Unclear
Dulaglutide 4.5 mg subcutaneous once weekly DULA_SC_4p5MG_QW	0.43 (0.11 to 1.59)	0.07 to 2.49	Unclear
Efsubaglutide alfa 3 mg injection once weekly EFSUBA_SC_3MG_QW	0.46 (0.01 to 27.40)	0.00 to 33.41	Unclear
Visepegenatide 150 µg injection once weekly VISEPE_SC_150UG_QW	0.46 (0.01 to 32.21)	0.00 to 36.45	Unclear
Semaglutide 0.5 mg subcutaneous once weekly SEMA_SC_0p5MG_QW	0.54 (0.21 to 1.33)	0.12 to 2.28	Unclear
Tirzepatide 5 mg subcutaneous once weekly TIRZ_SC_5MG_QW	0.54 (0.17 to 1.54)	0.10 to 2.61	Unclear
Lixisenatide 20 ug subcutaneous once daily LIXI_SC_20UG_QD	0.56 (0.14 to 2.11)	0.09 to 3.22	Unclear
Polyethylene glycol loxenatide 300 µg injection once weekly PEGLOX_SC_300UG_QW	0.57 (0.01 to 42.21)	0.00 to 50.56	Unclear
Dulaglutide 1.5 mg subcutaneous once weekly DULA_SC_1p5MG_QW	0.58 (0.22 to 1.39)	0.13 to 2.38	Unclear
Polyethylene glycol loxenatide 400 µg injection once weekly PEGLOX_SC_400UG_QW	0.59 (0.01 to 41.91)	0.01 to 52.80	Unclear
Tirzepatide 12 mg injection once weekly TIRZ_SC_12MG_QW	0.60 (0.01 to 43.17)	0.01 to 48.79	Unclear
Vildagliptin VILDAGLIPTIN	0.63 (0.01 to 45.64)	0.00 to 53.81	Unclear
Additional oad OTHER_ACTIVE_additional_OAD	0.65 (0.09 to 3.73)	0.06 to 5.21	Unclear
Safiglipron (HRS-7535) 15 mg tablet once daily SAFIGL_PO_15MG_QD	0.67 (0.01 to 44.80)	0.01 to 55.50	Unclear
BGM0504 5 mg injection once weekly BGM050_SC_5MG_QW	0.69 (0.01 to 59.39)	0.01 to 69.38	Unclear
Safiglipron (HRS-7535) 90 mg tablet once daily SAFIGL_PO_90MG_QD	0.70 (0.01 to 50.22)	0.01 to 58.32	Unclear
Safiglipron (HRS-7535) 60 mg tablet once daily SAFIGL_PO_60MG_QD	0.70 (0.01 to 60.39)	0.00 to 69.47	Unclear
Metformin METFORMIN	0.71 (0.13 to 3.22)	0.09 to 5.09	Unclear
BGM0504 10 mg injection once weekly BGM050_SC_10MG_QW	0.72 (0.01 to 60.85)	0.01 to 71.09	Unclear
Safiglipron (HRS-7535) 30 mg tablet once daily SAFIGL_PO_30MG_QD	0.72 (0.01 to 55.24)	0.01 to 58.98	Unclear
BGM0504 15 mg injection once weekly BGM050_SC_15MG_QW	0.72 (0.01 to 59.18)	0.01 to 66.36	Unclear
Tirzepatide 15 mg subcutaneous once weekly TIRZ_SC_15MG_QW	0.73 (0.26 to 1.97)	0.15 to 3.30	Unclear
Semaglutide 7 mg oral once daily (original tablet) SEMA_PO_7MG_QD	0.88 (0.42 to 1.87)	0.21 to 3.71	Unclear
Liraglutide 1.8 mg subcutaneous once daily LIRA_SC_1p8MG_QD	0.89 (0.50 to 1.55)	0.23 to 3.31	Unclear
Insulin icodec and semaglutide (IcoSema) subcutaneous once weekly titrated ICOSEMA_SC_TIT_QW	0.92 (0.19 to 4.01)	0.13 to 6.02	Unclear
Sitagliptin SITAGLIPTIN	0.93 (0.46 to 1.83)	0.23 to 3.60	Unclear
Semaglutide 14 mg oral once daily (original tablet) SEMA_PO_14MG_QD	0.95 (0.49 to 1.82)	0.24 to 3.89	Unclear
Semaglutide 2.4 mg subcutaneous once weekly SEMA_SC_2p4MG_QW	0.98 (0.25 to 3.71)	0.16 to 5.84	Unclear
Semaglutide 1.0 mg subcutaneous once weekly SEMA_SC_1p0MG_QW	1.03 (0.48 to 2.18)	0.25 to 4.08	Unclear
Exenatide extended release 2 mg subcutaneous once weekly EXENER_SC_2MG_QW	1.08 (0.46 to 2.46)	0.25 to 4.53	Unclear
Liraglutide 1.2 mg subcutaneous once daily LIRA_SC_1p2MG_QD	1.13 (0.37 to 3.09)	0.22 to 5.31	Unclear
Semaglutide 3 mg oral once daily (original tablet) SEMA_PO_3MG_QD	1.17 (0.57 to 2.45)	0.30 to 4.90	Unclear
Albiglutide 50 mg subcutaneous once weekly ALBI_SC_50MG_QW	1.23 (0.27 to 5.00)	0.17 to 7.75	Unclear
Insulin detemir INS_DETEMIR	1.23 (0.21 to 7.80)	0.15 to 10.32	Unclear
Exenatide 10 ug subcutaneous twice daily EXEN_SC_10UG_BID	1.25 (0.49 to 3.02)	0.26 to 5.30	Unclear
Semaglutide 2.0 mg subcutaneous once weekly SEMA_SC_2p0MG_QW	1.39 (0.07 to 24.32)	0.06 to 28.95	Unclear
Bofanglutide (GZR18) 4 mg injection once weekly BOFANG_SC_4MG_QW	1.77 (0.07 to 84.84)	0.05 to 95.87	Unclear
Mazdutide 6 mg subcutaneous once weekly MAZD_SC_6MG_QW	1.94 (0.10 to 34.29)	0.08 to 43.34	Unclear
Insulin glargine INS_GLARGINE	2.37 (1.10 to 4.84)	0.57 to 9.06	Worse
Insulin lispro (prandial) INS_LISPRO	2.46 (0.92 to 6.38)	0.51 to 11.20	Unclear
Cotadutide 300 ug subcutaneous once daily COTA_SC_300UG_QD	2.57 (0.30 to 29.62)	0.22 to 38.49	Unclear
Insulin aspart (prandial) INS_ASPART	2.59 (0.64 to 9.99)	0.42 to 15.71	Unclear
Sulfonylurea OTHER_ACTIVE_sulfonylurea	2.74 (0.55 to 12.88)	0.35 to 19.37	Unclear
Insulin degludec and liraglutide (IDegLira) subcutaneous once daily titrated IDEGLIRA_SC_TIT_QD	2.74 (1.36 to 5.16)	0.67 to 10.44	Worse
IGlarLixi 2:1 pen subcutaneous once daily titrated IGLARLIXI2_SC_TIT_QD	2.96 (1.07 to 7.29)	0.64 to 12.48	Worse
Glimepiride GLIMEPIRIDE	3.20 (0.78 to 12.35)	0.50 to 19.14	Unclear
Insulin degludec INS_DEGLUDEC	3.95 (1.77 to 8.24)	0.94 to 15.54	Worse
Liraglutide 0.9 mg injection once daily LIRA_SC_0p9MG_QD	4.81 (0.45 to 57.10)	0.34 to 71.89	Unclear
Premixed insulin INS_PREMIX	5.21 (1.52 to 17.56)	0.87 to 27.03	Worse
Basal bolus insulin OTHER_ACTIVE_basal_bolus_insulin	11.72 (1.91 to 84.80)	1.32 to 116	Worse

Ranking

How likely each treatment is to be among the best. Rankings ignore the size of differences and their certainty, so read them with the effects above.

League table

Every treatment against every other: hazard ratio (from event counts) of the row treatment versus the column treatment, posterior median and 95% credible interval. Green: row clearly better; red: row clearly worse.

Every treatment in a row compared with every treatment in a column
Row versus column	PLACEBO	PEGLOX_SC_0p3MG_QW	DULA_SC_3p0MG_QW	SEMA_SC_16MG_QW	SEMA_SC_8MG_QW	PIOGLITAZONE	MAZD_SC_4p5MG_QW	MAZD_SC_3MG_QW	STANDARD_CARE	DULA_SC_0p75MG_QW	TIRZ_SC_10MG_QW	DULA_SC_4p5MG_QW	EFSUBA_SC_3MG_QW	VISEPE_SC_150UG_QW	SEMA_SC_0p5MG_QW	TIRZ_SC_5MG_QW	LIXI_SC_20UG_QD	PEGLOX_SC_300UG_QW	DULA_SC_1p5MG_QW	PEGLOX_SC_400UG_QW	TIRZ_SC_12MG_QW	VILDAGLIPTIN	OTHER_ACTIVE_additional_OAD	SAFIGL_PO_15MG_QD	BGM050_SC_5MG_QW	SAFIGL_PO_90MG_QD	SAFIGL_PO_60MG_QD	METFORMIN	BGM050_SC_10MG_QW	SAFIGL_PO_30MG_QD	BGM050_SC_15MG_QW	TIRZ_SC_15MG_QW	SEMA_PO_7MG_QD	LIRA_SC_1p8MG_QD	ICOSEMA_SC_TIT_QW	SITAGLIPTIN	SEMA_PO_14MG_QD	SEMA_SC_2p4MG_QW	SEMA_SC_1p0MG_QW	EXENER_SC_2MG_QW	LIRA_SC_1p2MG_QD	SEMA_PO_3MG_QD	ALBI_SC_50MG_QW	INS_DETEMIR	EXEN_SC_10UG_BID	SEMA_SC_2p0MG_QW	BOFANG_SC_4MG_QW	MAZD_SC_6MG_QW	INS_GLARGINE	INS_LISPRO	COTA_SC_300UG_QD	INS_ASPART	OTHER_ACTIVE_sulfonylurea	IDEGLIRA_SC_TIT_QD	IGLARLIXI2_SC_TIT_QD	GLIMEPIRIDE	INS_DEGLUDEC	LIRA_SC_0p9MG_QD	INS_PREMIX	OTHER_ACTIVE_basal_bolus_insulin
PLACEBO	PLACEBO	8.36 0.30 to 404	6.78 1.09 to 52.41	4.87 0.18 to 273	4.81 0.19 to 315	4.80 0.79 to 53.87	4.42 0.19 to 272	4.08 0.14 to 274	3.63 0.48 to 42.95	2.74 0.79 to 11.79	2.32 0.80 to 7.19	2.30 0.63 to 9.11	2.15 0.04 to 182	2.15 0.03 to 171	1.86 0.75 to 4.85	1.85 0.65 to 5.84	1.78 0.47 to 7.16	1.77 0.02 to 173	1.73 0.72 to 4.49	1.69 0.02 to 169	1.67 0.02 to 164	1.60 0.02 to 189	1.53 0.27 to 11.35	1.48 0.02 to 144	1.45 0.02 to 156	1.43 0.02 to 158	1.43 0.02 to 177	1.41 0.31 to 7.76	1.40 0.02 to 159	1.40 0.02 to 154	1.38 0.02 to 173	1.37 0.51 to 3.91	1.13 0.53 to 2.38	1.12 0.65 to 2.00	1.09 0.25 to 5.20	1.08 0.55 to 2.18	1.06 0.55 to 2.06	1.02 0.27 to 4.01	0.97 0.46 to 2.10	0.93 0.41 to 2.19	0.89 0.32 to 2.67	0.85 0.41 to 1.76	0.81 0.20 to 3.68	0.81 0.13 to 4.69	0.80 0.33 to 2.02	0.72 0.04 to 13.62	0.56 0.01 to 15.14	0.52 0.03 to 9.93	0.42 0.21 to 0.91	0.41 0.16 to 1.09	0.39 0.03 to 3.37	0.39 0.10 to 1.56	0.37 0.08 to 1.82	0.36 0.19 to 0.73	0.34 0.14 to 0.94	0.31 0.08 to 1.28	0.25 0.12 to 0.56	0.21 0.02 to 2.21	0.19 0.06 to 0.66	0.09 0.01 to 0.52
PEGLOX_SC_0p3MG_QW	0.12 0.00 to 3.36	PEGLOX_SC_0p3MG_QW	0.81 0.01 to 40.76	0.58 0.00 to 112	0.56 0.00 to 120	0.59 0.01 to 36.38	0.52 0.00 to 100	0.49 0.00 to 93.08	0.45 0.01 to 28.66	0.33 0.01 to 11.93	0.28 0.00 to 9.55	0.27 0.00 to 9.70	0.25 0.00 to 62.71	0.25 0.00 to 59.70	0.22 0.00 to 7.58	0.22 0.00 to 8.06	0.21 0.00 to 8.29	0.20 0.00 to 64.08	0.21 0.00 to 6.36	0.20 0.00 to 57.42	0.19 0.00 to 51.34	0.18 0.00 to 63.58	0.18 0.00 to 8.75	0.18 0.00 to 51.54	0.18 0.00 to 57.98	0.17 0.00 to 54.26	0.17 0.00 to 66.55	0.17 0.00 to 4.99	0.16 0.00 to 57.89	0.16 0.00 to 49.70	0.15 0.00 to 59.04	0.17 0.00 to 5.62	0.14 0.00 to 4.11	0.13 0.00 to 3.82	0.13 0.00 to 5.00	0.13 0.00 to 3.93	0.13 0.00 to 3.65	0.12 0.00 to 4.72	0.12 0.00 to 3.58	0.11 0.00 to 3.44	0.11 0.00 to 3.46	0.10 0.00 to 2.94	0.10 0.00 to 4.05	0.09 0.00 to 3.83	0.10 0.00 to 3.07	0.09 0.00 to 6.73	0.06 0.00 to 7.09	0.06 0.00 to 6.19	0.05 0.00 to 1.61	0.05 0.00 to 1.59	0.04 0.00 to 2.50	0.05 0.00 to 1.75	0.04 0.00 to 1.74	0.04 0.00 to 1.31	0.04 0.00 to 1.37	0.04 0.00 to 1.50	0.03 0.00 to 0.91	0.02 0.00 to 1.46	0.02 0.00 to 0.79	0.01 0.00 to 0.48
DULA_SC_3p0MG_QW	0.15 0.02 to 0.92	1.24 0.02 to 85.93	DULA_SC_3p0MG_QW	0.71 0.01 to 60.91	0.71 0.02 to 62.91	0.72 0.05 to 13.73	0.64 0.02 to 57.42	0.57 0.01 to 59.65	0.53 0.04 to 10.14	0.40 0.04 to 3.90	0.34 0.04 to 2.72	0.34 0.05 to 1.97	0.32 0.00 to 37.32	0.31 0.00 to 36.39	0.27 0.03 to 2.03	0.27 0.03 to 2.01	0.26 0.03 to 2.41	0.26 0.00 to 34.25	0.25 0.04 to 1.49	0.24 0.00 to 34.69	0.24 0.00 to 32.27	0.22 0.00 to 35.92	0.22 0.02 to 3.38	0.22 0.00 to 29.09	0.21 0.00 to 34.95	0.20 0.00 to 28.19	0.21 0.00 to 33.12	0.21 0.02 to 2.24	0.20 0.00 to 34.44	0.20 0.00 to 30.53	0.19 0.00 to 33.20	0.20 0.02 to 1.42	0.16 0.02 to 1.18	0.16 0.02 to 1.08	0.16 0.01 to 1.66	0.16 0.02 to 1.12	0.15 0.02 to 1.05	0.15 0.01 to 1.46	0.14 0.02 to 0.98	0.13 0.02 to 1.00	0.13 0.01 to 1.10	0.13 0.02 to 0.88	0.12 0.01 to 1.23	0.12 0.01 to 1.51	0.12 0.01 to 0.83	0.11 0.00 to 3.36	0.08 0.00 to 3.57	0.07 0.00 to 2.37	0.06 0.01 to 0.45	0.06 0.01 to 0.43	0.06 0.00 to 0.99	0.06 0.01 to 0.53	0.05 0.00 to 0.58	0.05 0.01 to 0.37	0.05 0.01 to 0.39	0.05 0.00 to 0.44	0.04 0.00 to 0.26	0.03 0.00 to 0.61	0.03 0.00 to 0.26	0.01 0.00 to 0.17
SEMA_SC_16MG_QW	0.21 0.00 to 5.65	1.73 0.01 to 291	1.42 0.02 to 67.80	SEMA_SC_16MG_QW	0.98 0.01 to 159	1.05 0.01 to 68.10	0.94 0.01 to 175	0.84 0.00 to 203	0.76 0.01 to 44.08	0.57 0.01 to 21.20	0.49 0.01 to 14.56	0.47 0.01 to 18.35	0.43 0.00 to 122	0.43 0.00 to 113	0.38 0.01 to 12.64	0.39 0.01 to 12.15	0.38 0.01 to 13.55	0.34 0.00 to 107	0.36 0.01 to 11.19	0.34 0.00 to 110	0.32 0.00 to 99.93	0.31 0.00 to 108	0.32 0.00 to 15.13	0.30 0.00 to 84.85	0.28 0.00 to 101	0.29 0.00 to 85.77	0.28 0.00 to 99.09	0.29 0.00 to 12.88	0.27 0.00 to 112	0.28 0.00 to 85.68	0.27 0.00 to 101	0.29 0.00 to 9.27	0.23 0.00 to 7.28	0.23 0.00 to 6.71	0.22 0.00 to 8.94	0.22 0.00 to 6.42	0.22 0.00 to 6.17	0.21 0.00 to 7.44	0.20 0.00 to 6.21	0.19 0.00 to 5.83	0.18 0.00 to 6.20	0.17 0.00 to 5.10	0.17 0.00 to 6.99	0.16 0.00 to 7.80	0.16 0.00 to 5.11	0.16 0.00 to 6.80	0.10 0.00 to 12.67	0.11 0.00 to 7.89	0.09 0.00 to 2.55	0.08 0.00 to 2.80	0.08 0.00 to 4.57	0.08 0.00 to 2.97	0.08 0.00 to 2.99	0.08 0.00 to 2.20	0.07 0.00 to 2.12	0.07 0.00 to 2.29	0.05 0.00 to 1.50	0.04 0.00 to 2.66	0.04 0.00 to 1.36	0.02 0.00 to 0.75
SEMA_SC_8MG_QW	0.21 0.00 to 5.35	1.78 0.01 to 229	1.40 0.02 to 62.48	1.02 0.01 to 142	SEMA_SC_8MG_QW	1.04 0.01 to 58.21	0.89 0.01 to 145	0.81 0.00 to 167	0.75 0.01 to 45.42	0.58 0.01 to 20.45	0.48 0.01 to 14.26	0.47 0.01 to 16.07	0.42 0.00 to 115	0.42 0.00 to 104	0.39 0.01 to 11.15	0.38 0.01 to 11.46	0.37 0.00 to 12.63	0.33 0.00 to 104	0.35 0.01 to 10.58	0.33 0.00 to 106	0.33 0.00 to 84.36	0.30 0.00 to 109	0.30 0.00 to 15.64	0.31 0.00 to 87.10	0.28 0.00 to 96.49	0.28 0.00 to 89.11	0.28 0.00 to 97.13	0.29 0.00 to 10.94	0.29 0.00 to 85.60	0.28 0.00 to 82.11	0.27 0.00 to 94.41	0.29 0.00 to 8.23	0.23 0.00 to 6.40	0.23 0.00 to 6.27	0.22 0.00 to 8.77	0.22 0.00 to 5.97	0.21 0.00 to 6.01	0.21 0.00 to 7.59	0.20 0.00 to 5.66	0.19 0.00 to 5.63	0.19 0.00 to 5.48	0.18 0.00 to 4.85	0.17 0.00 to 6.09	0.16 0.00 to 7.58	0.16 0.00 to 4.67	0.15 0.00 to 6.68	0.10 0.00 to 11.94	0.10 0.00 to 8.02	0.09 0.00 to 2.48	0.08 0.00 to 2.38	0.07 0.00 to 4.21	0.08 0.00 to 2.67	0.08 0.00 to 2.78	0.08 0.00 to 2.14	0.07 0.00 to 2.03	0.06 0.00 to 2.35	0.05 0.00 to 1.47	0.04 0.00 to 2.48	0.04 0.00 to 1.20	0.02 0.00 to 0.74
PIOGLITAZONE	0.21 0.02 to 1.27	1.69 0.03 to 123	1.39 0.07 to 21.84	0.95 0.01 to 82.13	0.97 0.02 to 85.38	PIOGLITAZONE	0.86 0.02 to 81.68	0.79 0.01 to 83.85	0.75 0.03 to 15.27	0.57 0.04 to 5.49	0.47 0.03 to 3.90	0.47 0.03 to 4.46	0.43 0.00 to 52.63	0.42 0.00 to 54.06	0.38 0.03 to 2.68	0.38 0.03 to 3.04	0.35 0.02 to 3.58	0.34 0.00 to 49.37	0.36 0.03 to 2.66	0.32 0.00 to 50.86	0.33 0.00 to 46.02	0.32 0.00 to 50.93	0.31 0.02 to 4.61	0.28 0.00 to 37.61	0.28 0.00 to 40.79	0.28 0.00 to 40.93	0.28 0.00 to 46.91	0.29 0.02 to 3.14	0.28 0.00 to 47.99	0.26 0.00 to 37.33	0.26 0.00 to 45.39	0.28 0.02 to 2.21	0.23 0.02 to 1.59	0.23 0.02 to 1.55	0.22 0.01 to 2.26	0.22 0.02 to 1.35	0.22 0.02 to 1.45	0.20 0.01 to 2.01	0.20 0.02 to 1.29	0.19 0.02 to 1.12	0.18 0.01 to 1.46	0.18 0.01 to 1.13	0.17 0.01 to 1.73	0.16 0.01 to 1.77	0.17 0.01 to 1.25	0.15 0.00 to 4.30	0.10 0.00 to 5.13	0.10 0.00 to 3.24	0.09 0.01 to 0.62	0.08 0.01 to 0.63	0.08 0.00 to 1.30	0.08 0.01 to 0.74	0.07 0.00 to 0.87	0.08 0.01 to 0.52	0.07 0.01 to 0.55	0.06 0.00 to 0.64	0.05 0.00 to 0.37	0.04 0.00 to 0.85	0.04 0.00 to 0.35	0.02 0.00 to 0.23
MAZD_SC_4p5MG_QW	0.23 0.00 to 5.39	1.93 0.01 to 294	1.57 0.02 to 66.28	1.06 0.01 to 195	1.12 0.01 to 189	1.17 0.01 to 61.25	MAZD_SC_4p5MG_QW	0.88 0.01 to 159	0.86 0.01 to 47.93	0.64 0.01 to 19.97	0.53 0.01 to 15.12	0.51 0.01 to 17.67	0.49 0.00 to 109	0.46 0.00 to 131	0.42 0.01 to 11.41	0.43 0.01 to 12.67	0.40 0.01 to 12.90	0.37 0.00 to 99.82	0.39 0.01 to 10.96	0.38 0.00 to 98.54	0.36 0.00 to 96.30	0.35 0.00 to 94.01	0.36 0.00 to 15.73	0.32 0.00 to 98.21	0.32 0.00 to 91.93	0.31 0.00 to 96.66	0.32 0.00 to 106	0.32 0.00 to 12.13	0.31 0.00 to 87.32	0.30 0.00 to 79.09	0.29 0.00 to 97.62	0.31 0.00 to 9.05	0.25 0.00 to 7.06	0.25 0.00 to 6.37	0.24 0.00 to 8.55	0.24 0.00 to 6.31	0.24 0.00 to 6.19	0.23 0.00 to 7.63	0.22 0.00 to 5.65	0.21 0.00 to 5.95	0.20 0.00 to 6.00	0.20 0.00 to 4.99	0.19 0.00 to 6.38	0.18 0.00 to 7.21	0.18 0.00 to 4.83	0.16 0.00 to 12.56	0.12 0.00 to 13.29	0.12 0.00 to 5.96	0.09 0.00 to 2.54	0.09 0.00 to 2.50	0.08 0.00 to 4.30	0.09 0.00 to 2.97	0.08 0.00 to 2.96	0.08 0.00 to 2.19	0.08 0.00 to 2.15	0.07 0.00 to 2.59	0.06 0.00 to 1.51	0.04 0.00 to 2.54	0.04 0.00 to 1.32	0.02 0.00 to 0.80
MAZD_SC_3MG_QW	0.24 0.00 to 7.04	2.04 0.01 to 361	1.76 0.02 to 83.55	1.18 0.00 to 227	1.23 0.01 to 220	1.26 0.01 to 73.98	1.13 0.01 to 186	MAZD_SC_3MG_QW	0.91 0.01 to 55.94	0.69 0.01 to 26.01	0.56 0.01 to 19.90	0.58 0.01 to 20.50	0.51 0.00 to 148	0.50 0.00 to 142	0.46 0.01 to 14.53	0.46 0.01 to 16.03	0.44 0.01 to 16.68	0.40 0.00 to 140	0.43 0.01 to 13.16	0.42 0.00 to 123	0.39 0.00 to 119	0.37 0.00 to 125	0.39 0.00 to 18.68	0.35 0.00 to 101	0.33 0.00 to 118	0.35 0.00 to 101	0.34 0.00 to 115	0.36 0.00 to 14.37	0.33 0.00 to 118	0.32 0.00 to 102	0.33 0.00 to 102	0.35 0.00 to 11.08	0.28 0.00 to 8.63	0.28 0.00 to 7.95	0.27 0.00 to 10.30	0.27 0.00 to 7.88	0.25 0.00 to 7.60	0.25 0.00 to 9.53	0.24 0.00 to 7.41	0.23 0.00 to 7.10	0.22 0.00 to 6.92	0.21 0.00 to 6.50	0.20 0.00 to 8.49	0.20 0.00 to 8.13	0.20 0.00 to 6.62	0.18 0.00 to 15.38	0.12 0.00 to 17.15	0.13 0.00 to 7.12	0.10 0.00 to 3.16	0.10 0.00 to 3.44	0.09 0.00 to 5.24	0.09 0.00 to 3.81	0.09 0.00 to 3.89	0.09 0.00 to 2.77	0.08 0.00 to 2.84	0.08 0.00 to 2.78	0.06 0.00 to 1.95	0.05 0.00 to 3.04	0.05 0.00 to 1.71	0.02 0.00 to 1.00
STANDARD_CARE	0.28 0.02 to 2.06	2.23 0.03 to 176	1.87 0.10 to 28.54	1.32 0.02 to 118	1.33 0.02 to 127	1.33 0.07 to 29.48	1.16 0.02 to 124	1.09 0.02 to 113	STANDARD_CARE	0.74 0.05 to 9.08	0.64 0.05 to 5.33	0.63 0.04 to 6.37	0.57 0.01 to 76.19	0.57 0.00 to 69.93	0.51 0.04 to 4.60	0.51 0.04 to 4.21	0.49 0.03 to 5.04	0.47 0.00 to 67.79	0.48 0.04 to 4.01	0.44 0.00 to 73.98	0.45 0.00 to 61.39	0.41 0.00 to 70.71	0.41 0.02 to 6.75	0.39 0.00 to 56.93	0.36 0.00 to 66.07	0.38 0.00 to 59.88	0.37 0.00 to 67.54	0.38 0.02 to 5.01	0.37 0.00 to 63.22	0.36 0.00 to 58.05	0.36 0.00 to 66.73	0.38 0.03 to 3.00	0.31 0.02 to 2.47	0.31 0.03 to 2.42	0.29 0.02 to 3.47	0.30 0.02 to 2.45	0.29 0.02 to 2.29	0.28 0.02 to 2.88	0.26 0.02 to 2.30	0.25 0.02 to 2.16	0.25 0.02 to 2.28	0.23 0.02 to 1.95	0.22 0.02 to 2.02	0.22 0.01 to 3.23	0.22 0.02 to 1.52	0.19 0.01 to 6.45	0.15 0.00 to 6.62	0.14 0.00 to 5.35	0.12 0.01 to 0.94	0.11 0.01 to 0.76	0.10 0.00 to 1.98	0.11 0.01 to 1.26	0.10 0.01 to 1.25	0.10 0.01 to 0.78	0.09 0.01 to 0.83	0.09 0.01 to 0.99	0.07 0.01 to 0.56	0.05 0.00 to 1.29	0.05 0.00 to 0.50	0.02 0.00 to 0.33
DULA_SC_0p75MG_QW	0.36 0.08 to 1.27	3.03 0.08 to 181	2.47 0.26 to 25.89	1.75 0.05 to 119	1.72 0.05 to 129	1.75 0.18 to 25.29	1.56 0.05 to 111	1.45 0.04 to 119	1.35 0.11 to 20.41	DULA_SC_0p75MG_QW	0.83 0.15 to 4.29	0.83 0.13 to 4.61	0.76 0.01 to 71.22	0.76 0.01 to 76.39	0.67 0.15 to 2.72	0.66 0.12 to 3.53	0.64 0.09 to 3.97	0.63 0.01 to 71.72	0.63 0.14 to 2.45	0.59 0.01 to 72.96	0.60 0.01 to 66.94	0.56 0.01 to 73.24	0.55 0.07 to 5.21	0.54 0.01 to 63.65	0.50 0.01 to 66.01	0.50 0.01 to 62.47	0.51 0.01 to 73.08	0.51 0.08 to 3.20	0.49 0.00 to 74.07	0.48 0.00 to 63.35	0.47 0.01 to 64.96	0.50 0.09 to 2.44	0.41 0.09 to 1.65	0.41 0.09 to 1.54	0.39 0.05 to 2.58	0.39 0.09 to 1.47	0.38 0.08 to 1.46	0.37 0.05 to 2.39	0.35 0.08 to 1.29	0.34 0.07 to 1.34	0.32 0.06 to 1.53	0.31 0.07 to 1.20	0.29 0.04 to 2.03	0.29 0.03 to 2.30	0.29 0.05 to 1.32	0.26 0.01 to 6.74	0.20 0.00 to 6.80	0.18 0.01 to 4.45	0.15 0.03 to 0.65	0.15 0.03 to 0.70	0.14 0.01 to 1.76	0.14 0.02 to 0.81	0.13 0.02 to 0.93	0.13 0.03 to 0.54	0.12 0.02 to 0.60	0.11 0.02 to 0.77	0.09 0.02 to 0.39	0.07 0.00 to 1.04	0.07 0.01 to 0.40	0.03 0.00 to 0.27
TIRZ_SC_10MG_QW	0.43 0.14 to 1.24	3.59 0.10 to 220	2.91 0.37 to 26.08	2.06 0.07 to 143	2.09 0.07 to 145	2.11 0.26 to 31.51	1.87 0.07 to 131	1.78 0.05 to 152	1.55 0.19 to 19.75	1.20 0.23 to 6.87	TIRZ_SC_10MG_QW	0.98 0.22 to 4.64	0.96 0.01 to 89.40	0.96 0.01 to 82.62	0.80 0.20 to 3.20	0.80 0.30 to 2.17	0.78 0.14 to 4.00	0.75 0.01 to 84.04	0.75 0.19 to 2.87	0.73 0.01 to 82.05	0.70 0.01 to 78.14	0.66 0.01 to 85.87	0.67 0.08 to 6.86	0.65 0.01 to 71.21	0.63 0.01 to 79.78	0.61 0.01 to 67.98	0.62 0.01 to 80.95	0.61 0.09 to 4.31	0.59 0.01 to 77.03	0.59 0.01 to 74.53	0.60 0.01 to 80.66	0.60 0.23 to 1.52	0.49 0.13 to 1.77	0.48 0.15 to 1.56	0.47 0.08 to 2.92	0.47 0.13 to 1.63	0.46 0.12 to 1.58	0.45 0.08 to 2.45	0.41 0.11 to 1.48	0.40 0.10 to 1.53	0.39 0.08 to 1.69	0.37 0.10 to 1.32	0.35 0.08 to 1.73	0.35 0.04 to 2.72	0.34 0.11 to 1.10	0.31 0.01 to 6.75	0.25 0.00 to 7.66	0.23 0.01 to 5.26	0.18 0.05 to 0.62	0.18 0.06 to 0.49	0.17 0.01 to 1.80	0.17 0.03 to 0.94	0.16 0.02 to 1.05	0.16 0.05 to 0.48	0.15 0.04 to 0.56	0.14 0.02 to 0.74	0.11 0.04 to 0.32	0.09 0.01 to 1.17	0.08 0.02 to 0.38	0.04 0.00 to 0.30
DULA_SC_4p5MG_QW	0.43 0.11 to 1.59	3.64 0.10 to 227	2.95 0.51 to 21.77	2.13 0.05 to 146	2.14 0.06 to 163	2.13 0.22 to 33.10	1.94 0.06 to 135	1.74 0.05 to 148	1.60 0.16 to 23.37	1.21 0.22 to 7.52	1.02 0.22 to 4.56	DULA_SC_4p5MG_QW	0.96 0.01 to 94.94	0.96 0.01 to 91.26	0.81 0.17 to 3.71	0.82 0.18 to 3.47	0.77 0.12 to 5.01	0.76 0.01 to 87.46	0.76 0.21 to 2.66	0.73 0.01 to 88.23	0.73 0.01 to 75.75	0.68 0.01 to 88.73	0.68 0.08 to 7.37	0.66 0.01 to 75.62	0.61 0.01 to 85.15	0.62 0.01 to 82.82	0.65 0.01 to 81.76	0.61 0.09 to 4.63	0.62 0.01 to 85.68	0.61 0.01 to 73.16	0.59 0.01 to 81.73	0.61 0.16 to 2.23	0.49 0.10 to 2.17	0.49 0.12 to 1.93	0.47 0.07 to 3.43	0.47 0.11 to 2.02	0.46 0.10 to 1.88	0.45 0.06 to 2.88	0.42 0.10 to 1.79	0.41 0.09 to 1.81	0.39 0.07 to 2.04	0.37 0.08 to 1.62	0.36 0.06 to 2.25	0.36 0.04 to 3.01	0.35 0.08 to 1.51	0.32 0.01 to 7.65	0.24 0.00 to 8.25	0.23 0.01 to 5.49	0.18 0.04 to 0.79	0.18 0.04 to 0.75	0.17 0.01 to 2.10	0.17 0.03 to 1.11	0.16 0.02 to 1.19	0.16 0.04 to 0.65	0.15 0.03 to 0.74	0.14 0.02 to 0.88	0.11 0.03 to 0.43	0.09 0.01 to 1.33	0.08 0.01 to 0.49	0.04 0.00 to 0.33
EFSUBA_SC_3MG_QW	0.46 0.01 to 27.40	3.95 0.02 to 1158	3.13 0.03 to 317	2.35 0.01 to 764	2.36 0.01 to 616	2.32 0.02 to 259	2.05 0.01 to 571	1.95 0.01 to 625	1.75 0.01 to 187	1.31 0.01 to 94.80	1.04 0.01 to 75.72	1.04 0.01 to 80.98	EFSUBA_SC_3MG_QW	0.98 0.00 to 351	0.88 0.01 to 56.78	0.85 0.01 to 58.46	0.82 0.01 to 63.79	0.81 0.00 to 335	0.80 0.01 to 55.13	0.78 0.00 to 322	0.75 0.00 to 385	0.70 0.00 to 389	0.73 0.01 to 78.32	0.71 0.00 to 303	0.66 0.00 to 364	0.66 0.00 to 263	0.66 0.00 to 351	0.66 0.01 to 59.25	0.65 0.00 to 312	0.63 0.00 to 261	0.64 0.00 to 306	0.64 0.01 to 44.49	0.52 0.01 to 33.07	0.51 0.01 to 31.94	0.51 0.00 to 40.87	0.49 0.01 to 31.39	0.49 0.01 to 30.82	0.46 0.00 to 38.14	0.45 0.01 to 29.02	0.42 0.01 to 27.45	0.41 0.00 to 28.31	0.39 0.00 to 23.88	0.37 0.00 to 28.90	0.37 0.00 to 32.32	0.36 0.00 to 24.27	0.32 0.00 to 62.65	0.23 0.00 to 52.99	0.24 0.00 to 37.01	0.19 0.00 to 12.60	0.18 0.00 to 12.85	0.17 0.00 to 18.38	0.19 0.00 to 13.52	0.17 0.00 to 13.82	0.17 0.00 to 10.76	0.15 0.00 to 10.33	0.14 0.00 to 10.64	0.11 0.00 to 7.92	0.09 0.00 to 10.86	0.09 0.00 to 6.30	0.04 0.00 to 3.56
VISEPE_SC_150UG_QW	0.46 0.01 to 32.21	3.93 0.02 to 1055	3.22 0.03 to 301	2.33 0.01 to 913	2.41 0.01 to 732	2.39 0.02 to 279	2.19 0.01 to 614	2.02 0.01 to 706	1.76 0.01 to 234	1.32 0.01 to 106	1.04 0.01 to 95.37	1.04 0.01 to 89.01	1.02 0.00 to 352	VISEPE_SC_150UG_QW	0.86 0.01 to 65.64	0.84 0.01 to 78.78	0.82 0.01 to 74.27	0.81 0.00 to 439	0.82 0.01 to 60.27	0.81 0.00 to 403	0.80 0.00 to 356	0.70 0.00 to 385	0.76 0.01 to 77.78	0.69 0.00 to 319	0.69 0.00 to 384	0.68 0.00 to 326	0.67 0.00 to 405	0.68 0.01 to 60.42	0.66 0.00 to 336	0.62 0.00 to 362	0.62 0.00 to 391	0.63 0.01 to 54.58	0.53 0.01 to 37.29	0.52 0.01 to 37.89	0.50 0.01 to 44.84	0.50 0.01 to 36.60	0.49 0.01 to 35.54	0.47 0.00 to 40.82	0.45 0.01 to 32.81	0.43 0.00 to 31.38	0.41 0.00 to 31.93	0.39 0.00 to 27.34	0.39 0.00 to 36.68	0.38 0.00 to 35.95	0.37 0.00 to 28.34	0.33 0.00 to 58.51	0.24 0.00 to 49.25	0.24 0.00 to 42.23	0.19 0.00 to 14.91	0.18 0.00 to 15.63	0.18 0.00 to 22.53	0.18 0.00 to 15.24	0.17 0.00 to 16.42	0.17 0.00 to 12.71	0.16 0.00 to 11.86	0.14 0.00 to 13.93	0.12 0.00 to 8.94	0.09 0.00 to 12.48	0.09 0.00 to 6.98	0.04 0.00 to 4.07
SEMA_SC_0p5MG_QW	0.54 0.21 to 1.33	4.61 0.13 to 245	3.67 0.49 to 30.30	2.62 0.08 to 175	2.58 0.09 to 180	2.61 0.37 to 32.48	2.35 0.09 to 163	2.15 0.07 to 166	1.96 0.22 to 25.92	1.48 0.37 to 6.68	1.25 0.31 to 4.99	1.23 0.27 to 5.72	1.14 0.02 to 103	1.16 0.02 to 102	SEMA_SC_0p5MG_QW	0.99 0.26 to 3.89	0.95 0.19 to 4.98	0.92 0.01 to 96.92	0.93 0.30 to 2.94	0.93 0.01 to 96.89	0.87 0.01 to 98.55	0.85 0.01 to 100	0.82 0.15 to 5.73	0.80 0.01 to 81.97	0.75 0.01 to 90.55	0.77 0.01 to 87.30	0.79 0.01 to 102	0.75 0.14 to 4.84	0.76 0.01 to 94.67	0.74 0.01 to 88.36	0.74 0.01 to 97.18	0.75 0.19 to 2.71	0.61 0.19 to 1.85	0.60 0.21 to 1.66	0.59 0.12 to 2.90	0.58 0.21 to 1.56	0.57 0.19 to 1.63	0.55 0.10 to 2.90	0.52 0.22 to 1.18	0.50 0.16 to 1.46	0.48 0.14 to 1.71	0.46 0.14 to 1.38	0.44 0.08 to 2.49	0.44 0.06 to 2.84	0.43 0.12 to 1.55	0.38 0.02 to 8.54	0.30 0.01 to 8.54	0.28 0.01 to 5.89	0.22 0.07 to 0.74	0.22 0.06 to 0.79	0.21 0.01 to 2.18	0.21 0.05 to 0.86	0.19 0.03 to 1.22	0.20 0.06 to 0.59	0.18 0.05 to 0.67	0.17 0.03 to 0.86	0.14 0.04 to 0.42	0.11 0.01 to 1.41	0.10 0.02 to 0.46	0.05 0.01 to 0.34
TIRZ_SC_5MG_QW	0.54 0.17 to 1.54	4.45 0.12 to 257	3.69 0.50 to 34.34	2.57 0.08 to 168	2.62 0.09 to 185	2.64 0.33 to 35.86	2.33 0.08 to 166	2.19 0.06 to 186	1.95 0.24 to 25.06	1.50 0.28 to 8.49	1.25 0.46 to 3.31	1.22 0.29 to 5.67	1.17 0.02 to 105	1.19 0.01 to 105	1.01 0.26 to 3.88	TIRZ_SC_5MG_QW	0.95 0.18 to 4.98	0.93 0.01 to 102	0.94 0.25 to 3.49	0.90 0.01 to 102	0.89 0.01 to 104	0.85 0.01 to 120	0.82 0.11 to 8.00	0.82 0.01 to 91.75	0.77 0.01 to 90.36	0.77 0.01 to 86.78	0.78 0.01 to 108	0.76 0.12 to 5.40	0.76 0.01 to 98.79	0.73 0.01 to 95.90	0.73 0.01 to 97.69	0.75 0.29 to 1.92	0.61 0.16 to 2.17	0.61 0.18 to 1.88	0.59 0.09 to 3.65	0.58 0.17 to 2.00	0.57 0.16 to 1.92	0.56 0.10 to 3.01	0.52 0.14 to 1.86	0.50 0.13 to 1.91	0.48 0.11 to 2.09	0.46 0.12 to 1.63	0.45 0.09 to 2.05	0.44 0.05 to 3.43	0.43 0.13 to 1.41	0.39 0.02 to 8.27	0.30 0.01 to 9.51	0.28 0.01 to 6.73	0.23 0.07 to 0.76	0.22 0.07 to 0.60	0.20 0.01 to 2.33	0.21 0.04 to 1.15	0.20 0.03 to 1.29	0.20 0.06 to 0.59	0.18 0.05 to 0.69	0.17 0.03 to 0.92	0.14 0.05 to 0.39	0.11 0.01 to 1.51	0.10 0.02 to 0.48	0.05 0.01 to 0.36
LIXI_SC_20UG_QD	0.56 0.14 to 2.11	4.74 0.12 to 290	3.90 0.42 to 39.74	2.66 0.07 to 194	2.70 0.08 to 215	2.82 0.28 to 41.71	2.52 0.08 to 186	2.29 0.06 to 192	2.05 0.20 to 31.47	1.56 0.25 to 11.36	1.28 0.25 to 7.15	1.30 0.20 to 8.14	1.22 0.02 to 112	1.22 0.01 to 119	1.06 0.20 to 5.33	1.05 0.20 to 5.47	LIXI_SC_20UG_QD	0.99 0.01 to 117	0.98 0.19 to 4.77	0.96 0.01 to 104	0.93 0.01 to 109	0.89 0.01 to 122	0.88 0.10 to 9.58	0.82 0.01 to 104	0.80 0.01 to 107	0.82 0.01 to 97.35	0.80 0.01 to 115	0.79 0.10 to 6.86	0.80 0.01 to 113	0.77 0.01 to 95.50	0.77 0.01 to 115	0.78 0.16 to 3.93	0.63 0.13 to 2.95	0.63 0.16 to 2.43	0.61 0.09 to 4.56	0.60 0.14 to 2.61	0.59 0.13 to 2.56	0.58 0.09 to 3.84	0.54 0.12 to 2.49	0.52 0.11 to 2.51	0.51 0.10 to 2.64	0.48 0.10 to 2.13	0.47 0.07 to 3.11	0.46 0.05 to 4.12	0.45 0.10 to 2.08	0.41 0.02 to 9.63	0.31 0.01 to 10.59	0.29 0.01 to 7.86	0.24 0.07 to 0.74	0.23 0.05 to 1.11	0.21 0.01 to 2.55	0.22 0.03 to 1.44	0.21 0.03 to 1.55	0.21 0.05 to 0.76	0.19 0.06 to 0.60	0.17 0.03 to 0.92	0.14 0.03 to 0.58	0.11 0.01 to 1.70	0.11 0.02 to 0.51	0.05 0.00 to 0.41
PEGLOX_SC_300UG_QW	0.57 0.01 to 42.21	5.03 0.02 to 1455	3.91 0.03 to 436	2.94 0.01 to 1119	3.02 0.01 to 1034	2.93 0.02 to 323	2.69 0.01 to 866	2.51 0.01 to 966	2.12 0.01 to 273	1.60 0.01 to 159	1.33 0.01 to 110	1.31 0.01 to 113	1.24 0.00 to 573	1.23 0.00 to 618	1.08 0.01 to 87.79	1.08 0.01 to 88.31	1.01 0.01 to 96.78	PEGLOX_SC_300UG_QW	1.01 0.01 to 78.56	0.94 0.00 to 421	0.98 0.00 to 495	0.88 0.00 to 614	0.89 0.01 to 102	0.85 0.00 to 480	0.82 0.00 to 503	0.80 0.00 to 511	0.84 0.00 to 522	0.82 0.01 to 84.22	0.82 0.00 to 456	0.81 0.00 to 416	0.78 0.00 to 457	0.79 0.01 to 66.40	0.65 0.01 to 52.43	0.64 0.01 to 48.94	0.62 0.01 to 59.62	0.61 0.01 to 50.42	0.60 0.01 to 48.43	0.59 0.00 to 51.81	0.55 0.01 to 41.92	0.52 0.00 to 41.62	0.51 0.01 to 39.67	0.49 0.00 to 38.71	0.48 0.00 to 44.74	0.45 0.00 to 52.57	0.47 0.00 to 38.66	0.42 0.00 to 83.74	0.30 0.00 to 73.64	0.29 0.00 to 52.97	0.24 0.00 to 18.92	0.24 0.00 to 18.65	0.21 0.00 to 28.02	0.22 0.00 to 20.40	0.21 0.00 to 20.36	0.21 0.00 to 16.40	0.19 0.00 to 16.43	0.18 0.00 to 16.13	0.15 0.00 to 11.65	0.12 0.00 to 16.64	0.11 0.00 to 9.07	0.05 0.00 to 5.52
DULA_SC_1p5MG_QW	0.58 0.22 to 1.39	4.68 0.16 to 250	3.95 0.67 to 27.06	2.78 0.09 to 161	2.83 0.09 to 189	2.77 0.38 to 36.40	2.54 0.09 to 163	2.31 0.08 to 183	2.06 0.25 to 27.95	1.59 0.41 to 7.27	1.34 0.35 to 5.14	1.31 0.38 to 4.72	1.24 0.02 to 111	1.23 0.02 to 113	1.08 0.34 to 3.36	1.06 0.29 to 4.08	1.02 0.21 to 5.19	0.99 0.01 to 110	DULA_SC_1p5MG_QW	0.96 0.01 to 104	0.97 0.01 to 100	0.89 0.01 to 120	0.89 0.14 to 7.81	0.85 0.01 to 87.70	0.82 0.01 to 98.00	0.83 0.01 to 96.85	0.83 0.01 to 99.21	0.81 0.16 to 4.57	0.81 0.01 to 103	0.78 0.01 to 89.07	0.79 0.01 to 102	0.80 0.23 to 2.78	0.65 0.20 to 2.06	0.65 0.23 to 1.73	0.62 0.12 to 3.42	0.62 0.21 to 1.76	0.61 0.20 to 1.77	0.59 0.11 to 3.04	0.55 0.20 to 1.55	0.53 0.17 to 1.71	0.51 0.14 to 1.91	0.50 0.15 to 1.49	0.47 0.09 to 2.65	0.47 0.07 to 3.11	0.46 0.13 to 1.60	0.41 0.02 to 8.75	0.32 0.01 to 9.36	0.30 0.02 to 6.10	0.24 0.08 to 0.77	0.23 0.07 to 0.82	0.22 0.02 to 2.32	0.22 0.05 to 1.06	0.21 0.03 to 1.28	0.21 0.07 to 0.63	0.20 0.05 to 0.72	0.18 0.04 to 0.92	0.15 0.05 to 0.44	0.12 0.01 to 1.52	0.11 0.03 to 0.50	0.05 0.01 to 0.36
PEGLOX_SC_400UG_QW	0.59 0.01 to 41.91	4.96 0.02 to 1639	4.15 0.03 to 440	2.95 0.01 to 1028	3.05 0.01 to 885	3.15 0.02 to 329	2.62 0.01 to 949	2.40 0.01 to 948	2.26 0.01 to 278	1.69 0.01 to 148	1.37 0.01 to 108	1.38 0.01 to 119	1.29 0.00 to 514	1.24 0.00 to 749	1.08 0.01 to 82.77	1.12 0.01 to 89.74	1.04 0.01 to 93.89	1.07 0.00 to 418	1.04 0.01 to 73.97	PEGLOX_SC_400UG_QW	0.98 0.00 to 456	0.91 0.00 to 510	0.91 0.01 to 100	0.86 0.00 to 442	0.84 0.00 to 514	0.83 0.00 to 452	0.85 0.00 to 528	0.84 0.01 to 76.64	0.82 0.00 to 487	0.78 0.00 to 457	0.81 0.00 to 402	0.84 0.01 to 66.87	0.68 0.01 to 51.17	0.66 0.01 to 46.33	0.65 0.01 to 54.98	0.63 0.01 to 46.70	0.63 0.01 to 45.96	0.59 0.00 to 55.90	0.56 0.01 to 41.41	0.55 0.01 to 39.80	0.53 0.00 to 45.71	0.50 0.00 to 39.12	0.49 0.00 to 44.60	0.47 0.00 to 43.05	0.48 0.00 to 38.68	0.42 0.00 to 76.47	0.30 0.00 to 76.61	0.31 0.00 to 56.09	0.25 0.00 to 19.53	0.24 0.00 to 19.54	0.22 0.00 to 25.29	0.23 0.00 to 21.41	0.22 0.00 to 21.06	0.22 0.00 to 16.48	0.20 0.00 to 16.81	0.19 0.00 to 15.94	0.15 0.00 to 11.12	0.12 0.00 to 17.32	0.11 0.00 to 9.35	0.05 0.00 to 5.51
TIRZ_SC_12MG_QW	0.60 0.01 to 43.17	5.30 0.02 to 1474	4.17 0.03 to 486	3.16 0.01 to 886	3.03 0.01 to 978	3.07 0.02 to 385	2.80 0.01 to 873	2.53 0.01 to 951	2.24 0.02 to 255	1.68 0.01 to 142	1.43 0.01 to 116	1.38 0.01 to 118	1.33 0.00 to 571	1.26 0.00 to 549	1.14 0.01 to 86.79	1.12 0.01 to 92.19	1.07 0.01 to 97.29	1.02 0.00 to 550	1.04 0.01 to 81.42	1.02 0.00 to 504	TIRZ_SC_12MG_QW	0.96 0.00 to 418	0.94 0.01 to 95.45	0.84 0.00 to 523	0.85 0.00 to 481	0.82 0.00 to 545	0.87 0.00 to 453	0.86 0.01 to 85.34	0.86 0.00 to 488	0.82 0.00 to 401	0.84 0.00 to 416	0.83 0.01 to 68.52	0.68 0.01 to 49.80	0.68 0.01 to 49.80	0.65 0.01 to 52.21	0.63 0.01 to 46.77	0.63 0.01 to 45.76	0.61 0.01 to 50.90	0.57 0.01 to 41.10	0.55 0.01 to 41.50	0.54 0.01 to 42.21	0.51 0.01 to 36.76	0.49 0.00 to 44.55	0.50 0.00 to 50.10	0.49 0.00 to 38.82	0.44 0.00 to 71.23	0.31 0.00 to 68.53	0.31 0.00 to 55.92	0.25 0.00 to 19.59	0.25 0.00 to 19.45	0.22 0.00 to 27.42	0.23 0.00 to 19.78	0.21 0.00 to 20.54	0.22 0.00 to 16.10	0.21 0.00 to 15.97	0.19 0.00 to 17.44	0.16 0.00 to 10.78	0.12 0.00 to 15.11	0.12 0.00 to 9.68	0.05 0.00 to 5.05
VILDAGLIPTIN	0.63 0.01 to 45.64	5.56 0.02 to 1537	4.49 0.03 to 466	3.19 0.01 to 1089	3.31 0.01 to 1057	3.17 0.02 to 432	2.84 0.01 to 1014	2.72 0.01 to 1040	2.45 0.01 to 297	1.77 0.01 to 165	1.51 0.01 to 118	1.47 0.01 to 123	1.42 0.00 to 616	1.43 0.00 to 654	1.18 0.01 to 91.03	1.18 0.01 to 91.44	1.13 0.01 to 83.02	1.14 0.00 to 554	1.12 0.01 to 88.44	1.09 0.00 to 528	1.04 0.00 to 477	VILDAGLIPTIN	1.01 0.01 to 111	0.93 0.00 to 469	0.93 0.00 to 516	0.91 0.00 to 533	0.93 0.00 to 519	0.88 0.01 to 86.56	0.89 0.00 to 557	0.83 0.00 to 549	0.87 0.00 to 488	0.88 0.01 to 64.16	0.73 0.01 to 52.95	0.71 0.01 to 50.86	0.69 0.01 to 65.98	0.68 0.01 to 54.21	0.66 0.01 to 49.94	0.67 0.00 to 55.05	0.60 0.01 to 49.15	0.59 0.00 to 45.64	0.56 0.00 to 45.85	0.54 0.00 to 42.17	0.53 0.00 to 44.86	0.53 0.00 to 49.20	0.51 0.00 to 40.31	0.46 0.00 to 79.07	0.32 0.00 to 82.08	0.33 0.00 to 58.09	0.27 0.00 to 19.37	0.27 0.00 to 19.51	0.24 0.00 to 29.38	0.24 0.00 to 22.49	0.23 0.00 to 20.58	0.23 0.00 to 16.64	0.21 0.00 to 16.13	0.20 0.00 to 15.74	0.16 0.00 to 11.95	0.14 0.00 to 13.95	0.12 0.00 to 9.88	0.05 0.00 to 5.29
OTHER_ACTIVE_additional_OAD	0.65 0.09 to 3.73	5.44 0.11 to 371	4.45 0.30 to 60.33	3.10 0.07 to 281	3.29 0.06 to 245	3.19 0.22 to 63.77	2.79 0.06 to 242	2.56 0.05 to 269	2.42 0.15 to 44.83	1.81 0.19 to 14.97	1.49 0.15 to 11.83	1.48 0.14 to 12.79	1.36 0.01 to 164	1.32 0.01 to 170	1.23 0.17 to 6.74	1.22 0.12 to 8.98	1.14 0.10 to 10.42	1.13 0.01 to 146	1.13 0.13 to 7.33	1.10 0.01 to 140	1.06 0.01 to 137	0.99 0.01 to 133	OTHER_ACTIVE_additional_OAD	0.96 0.01 to 141	0.91 0.01 to 134	0.91 0.01 to 141	0.96 0.01 to 143	0.93 0.08 to 9.23	0.89 0.01 to 143	0.87 0.01 to 133	0.86 0.01 to 140	0.90 0.09 to 6.80	0.74 0.09 to 4.79	0.73 0.09 to 4.55	0.73 0.06 to 6.18	0.69 0.09 to 4.24	0.68 0.08 to 4.44	0.67 0.06 to 6.09	0.63 0.09 to 3.41	0.60 0.07 to 3.75	0.57 0.07 to 4.26	0.55 0.07 to 3.64	0.53 0.04 to 5.57	0.52 0.04 to 6.01	0.52 0.06 to 3.70	0.47 0.02 to 14.55	0.35 0.00 to 15.36	0.33 0.01 to 10.43	0.27 0.03 to 1.83	0.26 0.03 to 1.95	0.25 0.01 to 3.81	0.25 0.03 to 1.92	0.24 0.02 to 2.53	0.24 0.03 to 1.58	0.22 0.02 to 1.59	0.20 0.02 to 1.92	0.16 0.02 to 1.15	0.13 0.01 to 2.47	0.12 0.01 to 1.10	0.05 0.00 to 0.67
SAFIGL_PO_15MG_QD	0.67 0.01 to 44.80	5.58 0.02 to 2110	4.65 0.03 to 478	3.38 0.01 to 1073	3.25 0.01 to 1086	3.51 0.03 to 356	3.12 0.01 to 1075	2.85 0.01 to 880	2.54 0.02 to 312	1.87 0.02 to 158	1.53 0.01 to 127	1.51 0.01 to 123	1.42 0.00 to 675	1.46 0.00 to 737	1.25 0.01 to 90.76	1.22 0.01 to 101	1.22 0.01 to 99.02	1.18 0.00 to 627	1.17 0.01 to 89.65	1.16 0.00 to 578	1.19 0.00 to 494	1.08 0.00 to 531	1.04 0.01 to 117	SAFIGL_PO_15MG_QD	0.95 0.00 to 547	0.95 0.00 to 524	1.00 0.00 to 563	0.97 0.01 to 84.69	0.94 0.00 to 528	0.94 0.00 to 376	0.88 0.00 to 586	0.92 0.01 to 70.73	0.77 0.01 to 55.96	0.76 0.01 to 53.97	0.73 0.01 to 66.77	0.73 0.01 to 51.52	0.70 0.01 to 49.86	0.70 0.01 to 54.88	0.64 0.01 to 47.65	0.61 0.01 to 44.34	0.60 0.01 to 47.71	0.57 0.01 to 40.00	0.55 0.00 to 48.61	0.54 0.00 to 53.24	0.53 0.01 to 40.64	0.49 0.00 to 88.52	0.34 0.00 to 75.40	0.36 0.00 to 55.23	0.29 0.00 to 19.68	0.27 0.00 to 20.81	0.25 0.00 to 29.34	0.26 0.00 to 23.70	0.25 0.00 to 21.48	0.24 0.00 to 18.39	0.23 0.00 to 17.30	0.21 0.00 to 18.88	0.17 0.00 to 12.81	0.14 0.00 to 19.59	0.13 0.00 to 10.31	0.06 0.00 to 5.71
BGM050_SC_5MG_QW	0.69 0.01 to 59.39	5.64 0.02 to 2246	4.71 0.03 to 676	3.56 0.01 to 1228	3.62 0.01 to 1232	3.60 0.02 to 534	3.16 0.01 to 1157	3.03 0.01 to 1161	2.75 0.02 to 444	1.99 0.02 to 193	1.59 0.01 to 159	1.64 0.01 to 162	1.51 0.00 to 826	1.46 0.00 to 802	1.33 0.01 to 123	1.30 0.01 to 124	1.25 0.01 to 139	1.22 0.00 to 690	1.21 0.01 to 114	1.19 0.00 to 657	1.17 0.00 to 615	1.07 0.00 to 668	1.10 0.01 to 143	1.05 0.00 to 629	BGM050_SC_5MG_QW	0.99 0.00 to 650	1.02 0.00 to 643	1.00 0.01 to 107	0.97 0.00 to 524	0.95 0.00 to 507	0.93 0.00 to 599	0.97 0.01 to 87.72	0.81 0.01 to 71.46	0.76 0.01 to 70.53	0.76 0.01 to 78.00	0.74 0.01 to 66.60	0.74 0.01 to 62.53	0.71 0.01 to 78.97	0.68 0.01 to 61.13	0.66 0.01 to 58.81	0.63 0.01 to 58.23	0.59 0.01 to 51.15	0.58 0.00 to 61.29	0.57 0.00 to 64.27	0.55 0.00 to 51.67	0.52 0.00 to 102	0.37 0.00 to 97.85	0.34 0.00 to 74.44	0.29 0.00 to 26.25	0.28 0.00 to 27.07	0.26 0.00 to 38.09	0.28 0.00 to 24.47	0.24 0.00 to 28.83	0.25 0.00 to 24.32	0.24 0.00 to 23.65	0.22 0.00 to 21.26	0.18 0.00 to 16.51	0.14 0.00 to 20.93	0.13 0.00 to 13.85	0.06 0.00 to 7.20
SAFIGL_PO_90MG_QD	0.70 0.01 to 50.22	5.93 0.02 to 1918	4.89 0.04 to 535	3.46 0.01 to 1492	3.53 0.01 to 1158	3.63 0.02 to 464	3.25 0.01 to 1196	2.89 0.01 to 1159	2.62 0.02 to 352	1.99 0.02 to 180	1.63 0.01 to 140	1.61 0.01 to 147	1.51 0.00 to 707	1.48 0.00 to 833	1.30 0.01 to 109	1.30 0.01 to 116	1.21 0.01 to 113	1.25 0.00 to 851	1.21 0.01 to 100	1.21 0.00 to 675	1.22 0.00 to 603	1.09 0.00 to 654	1.10 0.01 to 126	1.05 0.00 to 458	1.02 0.00 to 579	SAFIGL_PO_90MG_QD	1.00 0.00 to 554	0.97 0.01 to 106	0.98 0.00 to 700	0.94 0.00 to 507	0.96 0.00 to 627	0.96 0.01 to 79.66	0.80 0.01 to 60.06	0.79 0.01 to 60.26	0.75 0.01 to 71.35	0.75 0.01 to 58.30	0.74 0.01 to 57.71	0.75 0.01 to 59.18	0.68 0.01 to 55.38	0.63 0.01 to 49.32	0.63 0.01 to 54.31	0.59 0.01 to 47.46	0.58 0.00 to 53.23	0.56 0.00 to 60.09	0.55 0.01 to 43.18	0.52 0.00 to 83.69	0.36 0.00 to 89.24	0.37 0.00 to 61.71	0.30 0.00 to 23.07	0.28 0.00 to 22.98	0.26 0.00 to 38.54	0.27 0.00 to 26.18	0.25 0.00 to 24.23	0.26 0.00 to 19.77	0.24 0.00 to 19.69	0.22 0.00 to 22.15	0.18 0.00 to 14.87	0.14 0.00 to 19.27	0.14 0.00 to 11.98	0.06 0.00 to 6.12
SAFIGL_PO_60MG_QD	0.70 0.01 to 60.39	5.96 0.02 to 2186	4.86 0.03 to 619	3.59 0.01 to 1227	3.64 0.01 to 1073	3.52 0.02 to 572	3.16 0.01 to 979	2.98 0.01 to 1304	2.69 0.01 to 381	1.95 0.01 to 199	1.62 0.01 to 161	1.55 0.01 to 181	1.51 0.00 to 635	1.49 0.00 to 851	1.27 0.01 to 124	1.28 0.01 to 132	1.25 0.01 to 125	1.19 0.00 to 700	1.21 0.01 to 116	1.17 0.00 to 835	1.15 0.00 to 546	1.07 0.00 to 679	1.04 0.01 to 151	1.00 0.00 to 624	0.98 0.00 to 604	1.00 0.00 to 658	SAFIGL_PO_60MG_QD	1.00 0.01 to 125	0.96 0.00 to 638	0.98 0.00 to 515	0.96 0.00 to 611	0.95 0.01 to 95.12	0.79 0.01 to 79.14	0.78 0.01 to 71.35	0.75 0.01 to 82.42	0.76 0.01 to 68.77	0.75 0.01 to 70.33	0.71 0.00 to 70.17	0.66 0.01 to 61.32	0.64 0.01 to 59.21	0.64 0.00 to 62.14	0.59 0.00 to 53.47	0.59 0.00 to 57.46	0.55 0.00 to 69.65	0.58 0.00 to 52.65	0.51 0.00 to 93.56	0.36 0.00 to 100	0.38 0.00 to 67.91	0.30 0.00 to 27.36	0.29 0.00 to 26.55	0.26 0.00 to 39.05	0.27 0.00 to 27.25	0.25 0.00 to 27.56	0.25 0.00 to 24.14	0.24 0.00 to 22.65	0.22 0.00 to 24.50	0.17 0.00 to 16.84	0.14 0.00 to 20.72	0.13 0.00 to 13.40	0.06 0.00 to 6.56
METFORMIN	0.71 0.13 to 3.22	5.72 0.20 to 316	4.84 0.45 to 53.96	3.46 0.08 to 255	3.41 0.09 to 281	3.48 0.32 to 55.17	3.09 0.08 to 259	2.81 0.07 to 246	2.64 0.20 to 44.82	1.95 0.31 to 12.46	1.64 0.23 to 10.62	1.65 0.22 to 11.24	1.51 0.02 to 159	1.48 0.02 to 158	1.34 0.21 to 7.15	1.32 0.19 to 8.59	1.27 0.15 to 9.60	1.22 0.01 to 151	1.24 0.22 to 6.21	1.20 0.01 to 145	1.16 0.01 to 136	1.13 0.01 to 151	1.07 0.11 to 12.91	1.03 0.01 to 129	1.00 0.01 to 149	1.03 0.01 to 125	1.00 0.01 to 138	METFORMIN	0.99 0.01 to 135	0.93 0.01 to 126	0.96 0.01 to 149	0.98 0.14 to 6.10	0.81 0.13 to 4.02	0.80 0.14 to 3.86	0.77 0.09 to 6.16	0.77 0.13 to 3.63	0.75 0.13 to 3.60	0.72 0.08 to 5.67	0.69 0.12 to 3.47	0.66 0.11 to 3.15	0.64 0.09 to 3.72	0.62 0.09 to 2.99	0.58 0.06 to 4.82	0.57 0.05 to 5.24	0.56 0.08 to 3.30	0.51 0.02 to 13.84	0.39 0.01 to 14.17	0.37 0.01 to 9.93	0.30 0.05 to 1.59	0.29 0.04 to 1.67	0.27 0.01 to 3.75	0.28 0.03 to 1.99	0.26 0.03 to 2.23	0.26 0.04 to 1.34	0.24 0.03 to 1.51	0.22 0.03 to 1.82	0.18 0.03 to 0.97	0.14 0.01 to 2.27	0.13 0.02 to 1.00	0.06 0.00 to 0.66
BGM050_SC_10MG_QW	0.72 0.01 to 60.85	6.13 0.02 to 2423	4.99 0.03 to 640	3.67 0.01 to 1396	3.45 0.01 to 1512	3.62 0.02 to 578	3.21 0.01 to 1173	3.03 0.01 to 1021	2.73 0.02 to 432	2.05 0.01 to 205	1.69 0.01 to 164	1.62 0.01 to 176	1.53 0.00 to 786	1.52 0.00 to 794	1.32 0.01 to 133	1.31 0.01 to 136	1.25 0.01 to 136	1.22 0.00 to 660	1.23 0.01 to 119	1.22 0.00 to 757	1.17 0.00 to 750	1.12 0.00 to 784	1.12 0.01 to 155	1.06 0.00 to 622	1.04 0.00 to 543	1.02 0.00 to 764	1.04 0.00 to 607	1.01 0.01 to 114	BGM050_SC_10MG_QW	0.98 0.00 to 691	0.98 0.00 to 687	0.97 0.01 to 102	0.79 0.01 to 76.49	0.81 0.01 to 68.74	0.77 0.01 to 89.73	0.75 0.01 to 71.50	0.75 0.01 to 68.47	0.72 0.00 to 72.14	0.68 0.01 to 65.94	0.66 0.01 to 66.51	0.65 0.00 to 62.79	0.60 0.01 to 58.33	0.59 0.00 to 66.93	0.57 0.00 to 69.43	0.58 0.00 to 58.02	0.52 0.00 to 104	0.38 0.00 to 103	0.38 0.00 to 76.12	0.30 0.00 to 28.73	0.28 0.00 to 29.30	0.27 0.00 to 38.51	0.29 0.00 to 29.01	0.26 0.00 to 29.99	0.26 0.00 to 23.25	0.24 0.00 to 24.72	0.22 0.00 to 24.73	0.18 0.00 to 16.17	0.14 0.00 to 22.91	0.14 0.00 to 14.72	0.06 0.00 to 8.33
SAFIGL_PO_30MG_QD	0.72 0.01 to 55.24	6.20 0.02 to 2306	5.09 0.03 to 601	3.61 0.01 to 1537	3.63 0.01 to 1421	3.80 0.03 to 508	3.37 0.01 to 1121	3.12 0.01 to 1255	2.75 0.02 to 407	2.10 0.02 to 203	1.69 0.01 to 152	1.65 0.01 to 153	1.58 0.00 to 706	1.61 0.00 to 797	1.36 0.01 to 115	1.36 0.01 to 118	1.29 0.01 to 121	1.24 0.00 to 594	1.28 0.01 to 109	1.29 0.00 to 730	1.22 0.00 to 709	1.20 0.00 to 781	1.15 0.01 to 145	1.07 0.00 to 530	1.06 0.00 to 661	1.06 0.00 to 561	1.02 0.00 to 642	1.07 0.01 to 108	1.02 0.00 to 779	SAFIGL_PO_30MG_QD	1.01 0.00 to 596	1.01 0.01 to 86.30	0.81 0.01 to 65.90	0.82 0.01 to 67.56	0.79 0.01 to 73.40	0.79 0.01 to 64.37	0.76 0.01 to 66.15	0.75 0.01 to 66.00	0.70 0.01 to 55.29	0.69 0.01 to 56.71	0.65 0.01 to 59.21	0.62 0.01 to 46.62	0.60 0.00 to 56.80	0.59 0.00 to 62.72	0.58 0.01 to 50.48	0.53 0.00 to 110	0.38 0.00 to 95.13	0.37 0.00 to 63.98	0.30 0.00 to 25.85	0.30 0.00 to 24.79	0.27 0.00 to 34.46	0.29 0.00 to 25.49	0.27 0.00 to 27.81	0.27 0.00 to 22.70	0.25 0.00 to 21.75	0.23 0.00 to 21.61	0.19 0.00 to 15.60	0.15 0.00 to 19.93	0.14 0.00 to 13.02	0.06 0.00 to 6.94
BGM050_SC_15MG_QW	0.72 0.01 to 59.18	6.63 0.02 to 2002	5.21 0.03 to 642	3.73 0.01 to 1416	3.75 0.01 to 1334	3.84 0.02 to 559	3.41 0.01 to 1364	3.07 0.01 to 1015	2.80 0.01 to 418	2.12 0.02 to 197	1.67 0.01 to 156	1.69 0.01 to 167	1.55 0.00 to 729	1.62 0.00 to 743	1.36 0.01 to 123	1.37 0.01 to 127	1.30 0.01 to 123	1.29 0.00 to 783	1.26 0.01 to 106	1.24 0.00 to 811	1.20 0.00 to 566	1.15 0.00 to 770	1.16 0.01 to 131	1.14 0.00 to 599	1.07 0.00 to 688	1.04 0.00 to 670	1.04 0.00 to 664	1.04 0.01 to 104	1.02 0.00 to 574	0.99 0.00 to 638	BGM050_SC_15MG_QW	1.03 0.01 to 96.14	0.82 0.01 to 66.76	0.81 0.01 to 68.65	0.80 0.01 to 88.58	0.80 0.01 to 63.73	0.78 0.01 to 61.35	0.76 0.01 to 70.43	0.72 0.01 to 57.68	0.69 0.01 to 59.90	0.66 0.00 to 55.06	0.62 0.00 to 49.27	0.60 0.00 to 58.95	0.60 0.00 to 61.57	0.58 0.00 to 53.04	0.54 0.00 to 106	0.39 0.00 to 108	0.39 0.00 to 72.34	0.31 0.00 to 25.67	0.30 0.00 to 27.15	0.27 0.00 to 37.36	0.29 0.00 to 27.37	0.27 0.00 to 29.20	0.27 0.00 to 22.14	0.25 0.00 to 20.70	0.23 0.00 to 22.39	0.18 0.00 to 16.26	0.15 0.00 to 21.22	0.14 0.00 to 13.05	0.06 0.00 to 7.71
TIRZ_SC_15MG_QW	0.73 0.26 to 1.97	6.02 0.18 to 355	4.93 0.70 to 42.29	3.48 0.11 to 226	3.49 0.12 to 242	3.52 0.45 to 45.56	3.20 0.11 to 213	2.89 0.09 to 229	2.65 0.33 to 32.58	2.00 0.41 to 10.75	1.68 0.66 to 4.27	1.63 0.45 to 6.43	1.56 0.02 to 141	1.58 0.02 to 140	1.34 0.37 to 5.21	1.33 0.52 to 3.50	1.29 0.25 to 6.44	1.27 0.02 to 138	1.25 0.36 to 4.43	1.19 0.01 to 140	1.20 0.01 to 130	1.14 0.02 to 142	1.11 0.15 to 11.25	1.09 0.01 to 114	1.03 0.01 to 131	1.05 0.01 to 113	1.05 0.01 to 140	1.02 0.16 to 7.01	1.03 0.01 to 129	0.99 0.01 to 118	0.98 0.01 to 132	TIRZ_SC_15MG_QW	0.81 0.23 to 2.72	0.80 0.28 to 2.37	0.79 0.14 to 4.59	0.78 0.24 to 2.54	0.76 0.22 to 2.47	0.74 0.14 to 3.99	0.69 0.21 to 2.34	0.67 0.18 to 2.40	0.65 0.16 to 2.69	0.62 0.18 to 2.10	0.59 0.13 to 2.77	0.58 0.07 to 4.25	0.57 0.19 to 1.81	0.53 0.03 to 11.31	0.41 0.01 to 12.48	0.37 0.02 to 8.43	0.30 0.10 to 0.98	0.29 0.11 to 0.80	0.28 0.02 to 2.96	0.28 0.05 to 1.47	0.26 0.05 to 1.64	0.26 0.09 to 0.76	0.24 0.07 to 0.92	0.23 0.04 to 1.18	0.18 0.07 to 0.50	0.15 0.01 to 1.92	0.14 0.03 to 0.62	0.06 0.01 to 0.44
SEMA_PO_7MG_QD	0.88 0.42 to 1.87	7.37 0.24 to 399	6.08 0.84 to 52.43	4.28 0.14 to 251	4.28 0.16 to 284	4.31 0.63 to 51.90	3.98 0.14 to 267	3.62 0.12 to 267	3.20 0.41 to 42.14	2.44 0.61 to 11.46	2.03 0.57 to 7.79	2.02 0.46 to 9.60	1.91 0.03 to 167	1.90 0.03 to 169	1.65 0.54 to 5.25	1.65 0.46 to 6.38	1.59 0.34 to 7.61	1.54 0.02 to 161	1.54 0.49 to 4.99	1.47 0.02 to 168	1.47 0.02 to 147	1.36 0.02 to 171	1.35 0.21 to 11.26	1.30 0.02 to 140	1.24 0.01 to 148	1.25 0.02 to 146	1.26 0.01 to 164	1.23 0.25 to 7.93	1.26 0.01 to 148	1.23 0.02 to 145	1.22 0.01 to 153	1.23 0.37 to 4.29	SEMA_PO_7MG_QD	0.99 0.41 to 2.43	0.96 0.19 to 5.17	0.95 0.42 to 2.22	0.93 0.47 to 1.85	0.91 0.19 to 4.34	0.85 0.32 to 2.37	0.82 0.29 to 2.39	0.79 0.24 to 2.72	0.75 0.37 to 1.52	0.71 0.15 to 3.93	0.73 0.11 to 4.86	0.71 0.23 to 2.30	0.64 0.03 to 13.24	0.50 0.01 to 13.82	0.46 0.02 to 9.64	0.37 0.13 to 1.11	0.36 0.11 to 1.25	0.34 0.03 to 3.40	0.34 0.08 to 1.62	0.32 0.06 to 1.93	0.32 0.12 to 0.88	0.30 0.09 to 1.04	0.27 0.06 to 1.35	0.22 0.08 to 0.64	0.18 0.02 to 2.03	0.17 0.04 to 0.74	0.07 0.01 to 0.53
LIRA_SC_1p8MG_QD	0.89 0.50 to 1.55	7.44 0.26 to 363	6.12 0.92 to 48.09	4.28 0.15 to 265	4.30 0.16 to 287	4.30 0.64 to 51.30	3.98 0.16 to 252	3.62 0.13 to 260	3.21 0.41 to 38.72	2.45 0.65 to 11.22	2.06 0.64 to 6.79	2.05 0.52 to 8.40	1.94 0.03 to 167	1.92 0.03 to 161	1.66 0.60 to 4.78	1.64 0.53 to 5.55	1.59 0.41 to 6.30	1.56 0.02 to 161	1.54 0.58 to 4.31	1.52 0.02 to 146	1.48 0.02 to 153	1.41 0.02 to 162	1.37 0.22 to 10.98	1.32 0.02 to 133	1.31 0.01 to 140	1.26 0.02 to 137	1.28 0.01 to 166	1.25 0.26 to 7.40	1.24 0.01 to 149	1.22 0.01 to 139	1.23 0.01 to 153	1.24 0.42 to 3.61	1.01 0.41 to 2.44	LIRA_SC_1p8MG_QD	0.97 0.21 to 4.68	0.96 0.46 to 2.02	0.94 0.42 to 2.08	0.91 0.21 to 3.92	0.86 0.37 to 2.06	0.83 0.32 to 2.20	0.79 0.29 to 2.25	0.77 0.31 to 1.78	0.73 0.17 to 3.46	0.73 0.11 to 4.31	0.71 0.26 to 1.99	0.65 0.04 to 12.07	0.50 0.01 to 13.39	0.46 0.03 to 9.01	0.38 0.18 to 0.85	0.36 0.13 to 1.05	0.35 0.03 to 3.20	0.34 0.08 to 1.47	0.33 0.07 to 1.46	0.33 0.16 to 0.65	0.30 0.12 to 0.86	0.28 0.07 to 1.18	0.23 0.10 to 0.49	0.18 0.01 to 2.15	0.17 0.05 to 0.63	0.08 0.01 to 0.46
ICOSEMA_SC_TIT_QW	0.92 0.19 to 4.01	7.78 0.20 to 458	6.42 0.60 to 69.84	4.46 0.11 to 330	4.52 0.11 to 360	4.55 0.44 to 68.93	4.10 0.12 to 316	3.66 0.10 to 336	3.44 0.29 to 57.52	2.58 0.39 to 18.53	2.12 0.34 to 13.16	2.13 0.29 to 14.20	1.95 0.02 to 204	2.02 0.02 to 192	1.70 0.34 to 8.34	1.71 0.27 to 10.85	1.63 0.22 to 11.65	1.62 0.02 to 177	1.60 0.29 to 8.19	1.55 0.02 to 191	1.55 0.02 to 177	1.46 0.02 to 190	1.37 0.16 to 15.61	1.38 0.01 to 167	1.32 0.01 to 170	1.33 0.01 to 172	1.33 0.01 to 188	1.31 0.16 to 11.47	1.29 0.01 to 180	1.27 0.01 to 173	1.26 0.01 to 179	1.26 0.22 to 7.37	1.04 0.19 to 5.28	1.04 0.21 to 4.81	ICOSEMA_SC_TIT_QW	0.99 0.20 to 4.48	0.98 0.19 to 4.61	0.94 0.12 to 6.84	0.88 0.22 to 3.32	0.85 0.16 to 4.07	0.83 0.15 to 4.29	0.79 0.14 to 3.82	0.75 0.10 to 5.98	0.74 0.07 to 6.48	0.73 0.12 to 4.11	0.67 0.03 to 17.37	0.51 0.01 to 18.68	0.46 0.02 to 12.67	0.39 0.07 to 1.97	0.37 0.06 to 2.08	0.35 0.02 to 5.06	0.36 0.06 to 2.05	0.33 0.04 to 2.87	0.34 0.07 to 1.66	0.31 0.05 to 1.80	0.29 0.04 to 2.14	0.23 0.04 to 1.17	0.19 0.01 to 3.14	0.17 0.03 to 1.20	0.08 0.01 to 0.84
SITAGLIPTIN	0.93 0.46 to 1.83	7.66 0.25 to 400	6.31 0.89 to 51.38	4.46 0.16 to 257	4.46 0.17 to 316	4.46 0.74 to 50.94	4.14 0.16 to 274	3.75 0.13 to 275	3.35 0.41 to 42.67	2.54 0.68 to 11.74	2.13 0.62 to 7.63	2.13 0.50 to 9.14	2.02 0.03 to 173	2.02 0.03 to 166	1.73 0.64 to 4.86	1.72 0.50 to 5.92	1.67 0.38 to 7.26	1.63 0.02 to 177	1.61 0.57 to 4.73	1.58 0.02 to 153	1.59 0.02 to 149	1.46 0.02 to 180	1.44 0.24 to 11.40	1.38 0.02 to 141	1.35 0.02 to 148	1.33 0.02 to 151	1.32 0.01 to 171	1.30 0.28 to 7.63	1.33 0.01 to 148	1.26 0.02 to 137	1.25 0.02 to 178	1.29 0.39 to 4.16	1.06 0.45 to 2.37	1.04 0.50 to 2.20	1.01 0.22 to 4.91	SITAGLIPTIN	0.98 0.46 to 2.06	0.95 0.21 to 4.50	0.90 0.39 to 2.11	0.87 0.35 to 2.14	0.83 0.30 to 2.36	0.80 0.34 to 1.76	0.76 0.16 to 3.82	0.76 0.12 to 4.48	0.74 0.24 to 2.29	0.67 0.04 to 12.73	0.52 0.01 to 14.44	0.48 0.02 to 9.99	0.39 0.15 to 1.04	0.38 0.12 to 1.22	0.36 0.03 to 3.28	0.36 0.09 to 1.48	0.34 0.07 to 1.81	0.34 0.14 to 0.83	0.32 0.10 to 1.00	0.29 0.07 to 1.34	0.24 0.09 to 0.63	0.19 0.02 to 2.13	0.18 0.04 to 0.73	0.08 0.01 to 0.53
SEMA_PO_14MG_QD	0.95 0.49 to 1.82	7.91 0.27 to 415	6.48 0.95 to 53.04	4.57 0.16 to 268	4.66 0.17 to 293	4.63 0.69 to 52.09	4.17 0.16 to 283	3.93 0.13 to 278	3.44 0.44 to 44.13	2.61 0.68 to 12.03	2.19 0.63 to 8.01	2.19 0.53 to 9.78	2.05 0.03 to 166	2.04 0.03 to 184	1.76 0.61 to 5.34	1.75 0.52 to 6.42	1.68 0.39 to 7.78	1.67 0.02 to 174	1.64 0.57 to 5.04	1.58 0.02 to 163	1.58 0.02 to 155	1.50 0.02 to 194	1.46 0.23 to 11.78	1.43 0.02 to 161	1.35 0.02 to 149	1.35 0.02 to 157	1.34 0.01 to 171	1.33 0.28 to 7.89	1.34 0.01 to 161	1.32 0.02 to 147	1.29 0.02 to 163	1.32 0.40 to 4.46	1.08 0.54 to 2.11	1.06 0.48 to 2.38	1.03 0.22 to 5.27	1.02 0.48 to 2.19	SEMA_PO_14MG_QD	0.96 0.22 to 4.46	0.92 0.36 to 2.38	0.89 0.32 to 2.39	0.85 0.27 to 2.75	0.81 0.41 to 1.56	0.78 0.17 to 4.05	0.77 0.12 to 5.02	0.76 0.25 to 2.36	0.68 0.04 to 14.08	0.54 0.01 to 14.57	0.48 0.03 to 10.01	0.40 0.15 to 1.08	0.38 0.12 to 1.27	0.37 0.03 to 3.48	0.37 0.09 to 1.65	0.35 0.07 to 1.87	0.35 0.14 to 0.87	0.32 0.10 to 1.07	0.30 0.07 to 1.40	0.24 0.09 to 0.64	0.20 0.02 to 2.15	0.18 0.05 to 0.76	0.08 0.01 to 0.54
SEMA_SC_2p4MG_QW	0.98 0.25 to 3.71	8.17 0.21 to 513	6.71 0.69 to 71.94	4.75 0.13 to 331	4.82 0.13 to 356	4.94 0.50 to 71.48	4.27 0.13 to 327	3.96 0.10 to 320	3.64 0.35 to 57.48	2.73 0.42 to 19.90	2.23 0.41 to 13.21	2.24 0.35 to 15.48	2.16 0.03 to 220	2.13 0.02 to 200	1.81 0.35 to 9.78	1.79 0.33 to 10.11	1.72 0.26 to 11.69	1.70 0.02 to 207	1.69 0.33 to 8.83	1.71 0.02 to 202	1.65 0.02 to 181	1.49 0.02 to 222	1.49 0.16 to 17.01	1.43 0.02 to 166	1.40 0.01 to 199	1.34 0.02 to 176	1.41 0.01 to 204	1.39 0.18 to 12.41	1.38 0.01 to 201	1.34 0.02 to 184	1.32 0.01 to 184	1.35 0.25 to 7.36	1.10 0.23 to 5.17	1.10 0.25 to 4.68	1.06 0.15 to 8.39	1.05 0.22 to 4.86	1.04 0.22 to 4.60	SEMA_SC_2p4MG_QW	0.93 0.20 to 4.49	0.90 0.19 to 4.53	0.88 0.16 to 4.93	0.83 0.17 to 3.90	0.80 0.11 to 6.14	0.79 0.08 to 7.24	0.77 0.15 to 4.04	0.73 0.03 to 17.20	0.56 0.01 to 19.60	0.51 0.02 to 12.87	0.41 0.09 to 1.99	0.39 0.08 to 2.15	0.38 0.02 to 4.81	0.38 0.05 to 2.73	0.36 0.04 to 2.92	0.36 0.08 to 1.60	0.33 0.07 to 1.90	0.30 0.04 to 2.19	0.25 0.05 to 1.22	0.20 0.01 to 3.07	0.18 0.03 to 1.17	0.08 0.01 to 0.78
SEMA_SC_1p0MG_QW	1.03 0.48 to 2.18	8.56 0.28 to 477	7.04 1.02 to 55.97	5.03 0.16 to 310	4.93 0.18 to 343	5.01 0.77 to 57.80	4.57 0.18 to 292	4.19 0.13 to 300	3.84 0.43 to 47.34	2.87 0.77 to 12.03	2.41 0.68 to 9.02	2.40 0.56 to 9.96	2.21 0.03 to 190	2.22 0.03 to 185	1.93 0.84 to 4.47	1.91 0.54 to 7.10	1.85 0.40 to 8.48	1.82 0.02 to 177	1.81 0.65 to 5.10	1.79 0.02 to 181	1.76 0.02 to 171	1.67 0.02 to 197	1.58 0.29 to 11.22	1.55 0.02 to 159	1.48 0.02 to 156	1.47 0.02 to 170	1.52 0.02 to 187	1.46 0.29 to 8.45	1.47 0.02 to 177	1.43 0.02 to 163	1.40 0.02 to 180	1.45 0.43 to 4.77	1.18 0.42 to 3.11	1.16 0.49 to 2.69	1.13 0.30 to 4.54	1.11 0.47 to 2.55	1.09 0.42 to 2.76	1.07 0.22 to 4.94	SEMA_SC_1p0MG_QW	0.97 0.39 to 2.34	0.92 0.31 to 2.70	0.89 0.32 to 2.34	0.84 0.18 to 4.53	0.84 0.13 to 5.02	0.83 0.25 to 2.63	0.75 0.04 to 15.34	0.58 0.01 to 16.03	0.53 0.03 to 11.32	0.43 0.16 to 1.24	0.42 0.13 to 1.41	0.40 0.03 to 4.00	0.40 0.13 to 1.30	0.38 0.07 to 2.08	0.38 0.14 to 1.00	0.35 0.11 to 1.17	0.32 0.07 to 1.58	0.26 0.09 to 0.73	0.21 0.02 to 2.58	0.20 0.05 to 0.85	0.09 0.01 to 0.61
EXENER_SC_2MG_QW	1.08 0.46 to 2.46	9.00 0.29 to 464	7.51 1.00 to 62.45	5.19 0.17 to 321	5.26 0.18 to 334	5.18 0.89 to 60.46	4.69 0.17 to 307	4.36 0.14 to 321	3.99 0.46 to 49.95	2.97 0.75 to 14.61	2.49 0.65 to 10.03	2.46 0.55 to 11.55	2.36 0.04 to 200	2.30 0.03 to 201	1.99 0.69 to 6.24	2.00 0.52 to 7.97	1.91 0.40 to 9.29	1.91 0.02 to 213	1.88 0.58 to 6.04	1.81 0.03 to 178	1.82 0.02 to 193	1.70 0.02 to 205	1.67 0.27 to 13.38	1.63 0.02 to 166	1.51 0.02 to 176	1.58 0.02 to 179	1.56 0.02 to 195	1.51 0.32 to 8.91	1.51 0.02 to 184	1.44 0.02 to 166	1.46 0.02 to 197	1.50 0.42 to 5.51	1.22 0.42 to 3.50	1.21 0.46 to 3.17	1.18 0.25 to 6.08	1.15 0.47 to 2.86	1.13 0.42 to 3.09	1.11 0.22 to 5.35	1.03 0.43 to 2.58	EXENER_SC_2MG_QW	0.96 0.28 to 3.32	0.92 0.32 to 2.61	0.88 0.18 to 4.89	0.88 0.18 to 4.40	0.85 0.25 to 2.91	0.78 0.04 to 15.81	0.61 0.01 to 16.48	0.56 0.03 to 11.65	0.45 0.15 to 1.35	0.44 0.13 to 1.56	0.42 0.03 to 4.35	0.42 0.10 to 1.81	0.39 0.07 to 2.41	0.40 0.14 to 1.10	0.37 0.10 to 1.29	0.34 0.07 to 1.71	0.27 0.09 to 0.84	0.22 0.02 to 2.63	0.20 0.05 to 0.95	0.09 0.01 to 0.66
LIRA_SC_1p2MG_QD	1.13 0.37 to 3.09	9.26 0.29 to 527	7.63 0.91 to 74.79	5.45 0.16 to 359	5.37 0.18 to 402	5.47 0.69 to 69.96	4.95 0.17 to 337	4.59 0.14 to 358	4.07 0.44 to 57.90	3.11 0.65 to 16.60	2.58 0.59 to 11.88	2.56 0.49 to 13.37	2.45 0.04 to 207	2.42 0.03 to 219	2.09 0.59 to 7.14	2.09 0.48 to 9.22	1.97 0.38 to 10.45	1.97 0.03 to 194	1.95 0.52 to 7.26	1.89 0.02 to 214	1.85 0.02 to 195	1.78 0.02 to 216	1.74 0.23 to 15.26	1.67 0.02 to 175	1.58 0.02 to 186	1.60 0.02 to 184	1.56 0.02 to 223	1.57 0.27 to 10.87	1.54 0.02 to 200	1.53 0.02 to 181	1.51 0.02 to 204	1.54 0.37 to 6.36	1.27 0.37 to 4.18	1.26 0.44 to 3.48	1.20 0.23 to 6.68	1.21 0.42 to 3.32	1.18 0.36 to 3.73	1.14 0.20 to 6.28	1.08 0.37 to 3.23	1.04 0.30 to 3.57	LIRA_SC_1p2MG_QD	0.96 0.28 to 3.03	0.92 0.16 to 5.59	0.91 0.12 to 6.49	0.89 0.23 to 3.43	0.82 0.04 to 16.24	0.64 0.01 to 18.87	0.57 0.03 to 12.70	0.47 0.13 to 1.70	0.46 0.11 to 1.80	0.44 0.03 to 4.57	0.43 0.09 to 2.14	0.41 0.07 to 2.52	0.41 0.12 to 1.35	0.38 0.10 to 1.55	0.35 0.06 to 2.04	0.28 0.08 to 0.97	0.23 0.02 to 3.06	0.21 0.04 to 1.10	0.09 0.01 to 0.73
SEMA_PO_3MG_QD	1.17 0.57 to 2.45	9.82 0.34 to 529	7.98 1.13 to 66.57	5.78 0.20 to 361	5.64 0.21 to 392	5.61 0.89 to 71.49	5.09 0.20 to 350	4.71 0.15 to 340	4.29 0.51 to 54.25	3.20 0.83 to 15.13	2.70 0.76 to 10.28	2.71 0.62 to 12.23	2.57 0.04 to 218	2.54 0.04 to 226	2.17 0.72 to 6.97	2.16 0.61 to 8.31	2.08 0.47 to 10.00	2.05 0.03 to 206	2.02 0.67 to 6.71	1.98 0.03 to 204	1.95 0.03 to 190	1.86 0.02 to 224	1.80 0.27 to 15.37	1.75 0.03 to 188	1.70 0.02 to 187	1.71 0.02 to 196	1.69 0.02 to 215	1.62 0.33 to 10.59	1.66 0.02 to 197	1.62 0.02 to 180	1.61 0.02 to 205	1.61 0.48 to 5.43	1.33 0.66 to 2.69	1.30 0.56 to 3.22	1.26 0.26 to 6.91	1.25 0.57 to 2.94	1.23 0.64 to 2.46	1.20 0.26 to 5.83	1.13 0.43 to 3.15	1.09 0.38 to 3.10	1.04 0.33 to 3.60	SEMA_PO_3MG_QD	0.96 0.20 to 5.43	0.94 0.15 to 6.13	0.93 0.29 to 3.08	0.85 0.05 to 16.90	0.67 0.01 to 18.72	0.60 0.03 to 12.78	0.49 0.18 to 1.46	0.47 0.14 to 1.63	0.45 0.04 to 4.39	0.45 0.10 to 2.12	0.42 0.08 to 2.52	0.42 0.17 to 1.17	0.40 0.12 to 1.40	0.37 0.08 to 1.86	0.29 0.11 to 0.86	0.24 0.02 to 2.80	0.22 0.05 to 1.02	0.10 0.01 to 0.70
ALBI_SC_50MG_QW	1.23 0.27 to 5.00	10.14 0.25 to 669	8.34 0.81 to 92.80	5.78 0.14 to 441	6.02 0.16 to 478	5.96 0.58 to 97.51	5.28 0.16 to 426	5.04 0.12 to 413	4.45 0.50 to 62.19	3.39 0.49 to 25.44	2.83 0.58 to 13.24	2.77 0.44 to 18.00	2.68 0.03 to 262	2.59 0.03 to 267	2.30 0.40 to 12.69	2.23 0.49 to 10.66	2.15 0.32 to 15.17	2.09 0.02 to 247	2.12 0.38 to 11.15	2.05 0.02 to 234	2.03 0.02 to 247	1.89 0.02 to 244	1.89 0.18 to 23.20	1.82 0.02 to 219	1.71 0.02 to 226	1.73 0.02 to 214	1.68 0.02 to 258	1.71 0.21 to 15.47	1.70 0.01 to 240	1.66 0.02 to 224	1.65 0.02 to 269	1.69 0.36 to 7.65	1.40 0.25 to 6.71	1.37 0.29 to 5.97	1.34 0.17 to 10.51	1.32 0.26 to 6.18	1.29 0.25 to 5.96	1.25 0.16 to 8.81	1.19 0.22 to 5.71	1.14 0.20 to 5.70	1.09 0.18 to 6.21	1.04 0.18 to 5.03	ALBI_SC_50MG_QW	0.99 0.09 to 9.38	0.97 0.23 to 4.06	0.88 0.04 to 22.52	0.68 0.01 to 24.78	0.62 0.02 to 17.33	0.52 0.10 to 2.39	0.49 0.15 to 1.59	0.47 0.02 to 6.34	0.48 0.06 to 3.70	0.44 0.05 to 3.74	0.45 0.09 to 2.01	0.42 0.08 to 2.08	0.38 0.05 to 2.65	0.31 0.06 to 1.39	0.25 0.01 to 4.14	0.23 0.04 to 1.35	0.10 0.01 to 1.00
INS_DETEMIR	1.23 0.21 to 7.80	10.59 0.26 to 727	8.49 0.66 to 120	6.08 0.13 to 490	6.25 0.13 to 500	6.07 0.56 to 112	5.41 0.14 to 461	5.01 0.12 to 482	4.51 0.31 to 89.06	3.42 0.44 to 32.98	2.82 0.37 to 23.25	2.80 0.33 to 26.31	2.72 0.03 to 280	2.64 0.03 to 307	2.28 0.35 to 16.15	2.28 0.29 to 19.04	2.15 0.24 to 22.04	2.24 0.02 to 269	2.14 0.32 to 15.11	2.13 0.02 to 262	2.01 0.02 to 265	1.90 0.02 to 296	1.93 0.17 to 26.28	1.84 0.02 to 248	1.74 0.02 to 269	1.78 0.02 to 254	1.81 0.01 to 292	1.76 0.19 to 18.66	1.74 0.01 to 292	1.70 0.02 to 251	1.66 0.02 to 283	1.72 0.24 to 13.44	1.38 0.21 to 9.21	1.38 0.23 to 9.11	1.36 0.15 to 13.35	1.32 0.22 to 8.42	1.29 0.20 to 8.43	1.27 0.14 to 11.80	1.19 0.20 to 7.53	1.13 0.23 to 5.67	1.10 0.15 to 8.50	1.06 0.16 to 6.59	1.01 0.11 to 10.63	INS_DETEMIR	0.97 0.14 to 7.36	0.92 0.03 to 26.41	0.69 0.01 to 28.80	0.65 0.02 to 18.97	0.52 0.08 to 3.76	0.50 0.07 to 3.91	0.47 0.02 to 7.72	0.48 0.06 to 4.02	0.45 0.04 to 5.04	0.45 0.07 to 3.15	0.42 0.06 to 3.38	0.38 0.04 to 4.00	0.31 0.05 to 2.29	0.25 0.01 to 5.33	0.23 0.03 to 2.26	0.10 0.01 to 1.34
EXEN_SC_10UG_BID	1.25 0.49 to 3.02	10.32 0.33 to 580	8.55 1.20 to 72.30	6.07 0.20 to 376	6.18 0.21 to 394	6.06 0.80 to 80.26	5.44 0.21 to 358	5.12 0.15 to 370	4.48 0.66 to 54.05	3.47 0.76 to 18.42	2.91 0.91 to 9.39	2.84 0.66 to 13.07	2.75 0.04 to 255	2.70 0.04 to 238	2.31 0.65 to 8.53	2.33 0.71 to 7.61	2.22 0.48 to 10.32	2.14 0.03 to 211	2.18 0.62 to 7.41	2.08 0.03 to 226	2.03 0.03 to 229	1.95 0.02 to 238	1.91 0.27 to 17.33	1.88 0.02 to 187	1.81 0.02 to 202	1.80 0.02 to 200	1.74 0.02 to 239	1.78 0.30 to 12.05	1.74 0.02 to 223	1.72 0.02 to 195	1.73 0.02 to 237	1.75 0.55 to 5.28	1.42 0.43 to 4.41	1.41 0.50 to 3.85	1.37 0.24 to 8.14	1.35 0.44 to 4.14	1.32 0.42 to 3.97	1.29 0.25 to 6.60	1.21 0.38 to 3.97	1.17 0.34 to 3.93	1.13 0.29 to 4.34	1.07 0.33 to 3.40	1.03 0.25 to 4.31	1.03 0.14 to 7.05	EXEN_SC_10UG_BID	0.90 0.05 to 19.09	0.71 0.01 to 20.60	0.65 0.03 to 14.74	0.52 0.18 to 1.54	0.51 0.22 to 1.16	0.48 0.04 to 5.07	0.49 0.10 to 2.52	0.46 0.08 to 2.69	0.46 0.16 to 1.31	0.43 0.13 to 1.35	0.39 0.08 to 1.95	0.32 0.11 to 0.95	0.26 0.02 to 3.21	0.24 0.07 to 0.85	0.11 0.01 to 0.77
SEMA_SC_2p0MG_QW	1.39 0.07 to 24.32	11.67 0.15 to 1275	9.38 0.30 to 313	6.42 0.15 to 559	6.60 0.15 to 669	6.83 0.23 to 271	6.12 0.08 to 827	5.49 0.07 to 819	5.23 0.15 to 184	3.92 0.15 to 88.31	3.18 0.15 to 67.13	3.11 0.13 to 74.60	3.09 0.02 to 484	3.06 0.02 to 563	2.63 0.12 to 50.31	2.54 0.12 to 55.12	2.44 0.10 to 54.55	2.36 0.01 to 529	2.43 0.11 to 47.61	2.38 0.01 to 500	2.29 0.01 to 451	2.16 0.01 to 528	2.15 0.07 to 64.55	2.02 0.01 to 431	1.94 0.01 to 480	1.93 0.01 to 476	1.96 0.01 to 547	1.95 0.07 to 54.02	1.92 0.01 to 488	1.90 0.01 to 460	1.85 0.01 to 489	1.88 0.09 to 39.46	1.56 0.08 to 29.37	1.54 0.08 to 28.10	1.48 0.06 to 38.47	1.49 0.08 to 26.37	1.46 0.07 to 26.80	1.37 0.06 to 32.09	1.33 0.07 to 25.97	1.28 0.06 to 24.88	1.22 0.06 to 24.49	1.17 0.06 to 21.62	1.14 0.04 to 27.51	1.08 0.04 to 31.70	1.11 0.05 to 21.66	SEMA_SC_2p0MG_QW	0.73 0.01 to 57.91	0.73 0.01 to 39.52	0.58 0.03 to 11.09	0.55 0.03 to 11.45	0.50 0.01 to 20.55	0.54 0.02 to 13.31	0.49 0.02 to 12.67	0.50 0.03 to 9.65	0.47 0.02 to 9.49	0.43 0.02 to 10.34	0.34 0.02 to 6.51	0.28 0.01 to 11.05	0.26 0.01 to 5.81	0.11 0.00 to 3.69
BOFANG_SC_4MG_QW	1.77 0.07 to 84.84	16.25 0.14 to 3259	12.49 0.28 to 883	9.93 0.08 to 1889	9.86 0.08 to 2133	9.53 0.20 to 749	8.63 0.08 to 2037	8.03 0.06 to 2031	6.73 0.15 to 600	4.97 0.15 to 319	4.05 0.13 to 232	4.10 0.12 to 232	4.29 0.02 to 1269	4.13 0.02 to 1257	3.39 0.12 to 183	3.30 0.11 to 172	3.27 0.09 to 191	3.36 0.01 to 1294	3.10 0.11 to 165	3.32 0.01 to 1217	3.18 0.01 to 1049	3.08 0.01 to 1376	2.88 0.07 to 216	2.93 0.01 to 1049	2.73 0.01 to 1075	2.75 0.01 to 1057	2.77 0.01 to 1154	2.58 0.07 to 167	2.66 0.01 to 1095	2.64 0.01 to 884	2.57 0.01 to 1130	2.46 0.08 to 140	1.99 0.07 to 95.75	1.99 0.07 to 98.56	1.95 0.05 to 120	1.91 0.07 to 98.03	1.86 0.07 to 91.32	1.80 0.05 to 101	1.71 0.06 to 87.48	1.64 0.06 to 89.34	1.57 0.05 to 88.19	1.49 0.05 to 77.89	1.48 0.04 to 83.23	1.44 0.03 to 95.48	1.41 0.05 to 73.69	1.38 0.02 to 157	BOFANG_SC_4MG_QW	0.98 0.01 to 101	0.76 0.03 to 39.69	0.71 0.02 to 37.18	0.69 0.01 to 59.92	0.68 0.02 to 43.85	0.67 0.02 to 40.92	0.66 0.02 to 33.79	0.62 0.02 to 33.28	0.57 0.02 to 35.51	0.45 0.02 to 22.82	0.37 0.01 to 32.17	0.33 0.01 to 19.45	0.16 0.00 to 10.97
MAZD_SC_6MG_QW	1.94 0.10 to 34.29	16.95 0.16 to 2007	13.55 0.42 to 405	9.52 0.13 to 1287	9.69 0.12 to 1195	9.83 0.31 to 408	8.53 0.17 to 945	7.78 0.14 to 1027	7.23 0.19 to 291	5.41 0.22 to 127	4.43 0.19 to 93.62	4.32 0.18 to 98.42	4.18 0.03 to 709	4.17 0.02 to 930	3.62 0.17 to 72.03	3.58 0.15 to 75.59	3.39 0.13 to 81.32	3.46 0.02 to 695	3.29 0.16 to 63.71	3.27 0.02 to 674	3.22 0.02 to 663	3.02 0.02 to 691	3.02 0.10 to 98.57	2.81 0.02 to 573	2.91 0.01 to 693	2.72 0.02 to 695	2.66 0.01 to 717	2.72 0.10 to 72.60	2.65 0.01 to 694	2.69 0.02 to 665	2.55 0.01 to 715	2.70 0.12 to 53.66	2.19 0.10 to 42.64	2.19 0.11 to 39.89	2.16 0.08 to 49.86	2.09 0.10 to 42.07	2.07 0.10 to 36.66	1.97 0.08 to 46.25	1.87 0.09 to 35.05	1.78 0.09 to 35.41	1.75 0.08 to 37.06	1.65 0.08 to 31.02	1.61 0.06 to 40.31	1.55 0.05 to 46.02	1.54 0.07 to 30.78	1.37 0.03 to 77.73	1.02 0.01 to 81.00	MAZD_SC_6MG_QW	0.82 0.04 to 15.16	0.77 0.03 to 15.65	0.72 0.02 to 25.86	0.75 0.03 to 18.13	0.69 0.03 to 18.44	0.71 0.03 to 13.27	0.65 0.03 to 13.53	0.60 0.02 to 13.36	0.49 0.02 to 9.23	0.39 0.01 to 15.30	0.36 0.02 to 8.21	0.16 0.01 to 4.41
INS_GLARGINE	2.37 1.10 to 4.84	19.90 0.62 to 1046	16.14 2.25 to 140	11.43 0.39 to 699	11.61 0.40 to 769	11.43 1.62 to 150	10.65 0.39 to 685	9.57 0.32 to 701	8.65 1.06 to 110	6.59 1.53 to 33.30	5.50 1.61 to 19.25	5.41 1.26 to 23.79	5.23 0.08 to 452	5.15 0.07 to 429	4.45 1.36 to 14.41	4.39 1.31 to 15.22	4.21 1.35 to 14.44	4.20 0.05 to 427	4.13 1.30 to 13.05	3.98 0.05 to 400	3.94 0.05 to 427	3.77 0.05 to 451	3.69 0.55 to 30.48	3.46 0.05 to 385	3.39 0.04 to 382	3.39 0.04 to 357	3.37 0.04 to 437	3.37 0.63 to 22.16	3.37 0.03 to 401	3.30 0.04 to 383	3.26 0.04 to 409	3.32 1.02 to 10.36	2.70 0.90 to 7.42	2.66 1.18 to 5.69	2.58 0.51 to 13.83	2.57 0.96 to 6.66	2.52 0.93 to 6.53	2.44 0.50 to 11.27	2.30 0.81 to 6.44	2.20 0.74 to 6.65	2.12 0.59 to 7.51	2.04 0.68 to 5.61	1.94 0.42 to 9.67	1.93 0.27 to 12.78	1.91 0.65 to 5.62	1.71 0.09 to 33.45	1.31 0.03 to 38.58	1.22 0.07 to 26.43	INS_GLARGINE	0.96 0.31 to 2.98	0.93 0.07 to 8.79	0.93 0.19 to 4.46	0.87 0.16 to 4.63	0.87 0.43 to 1.72	0.81 0.39 to 1.68	0.74 0.23 to 2.45	0.60 0.25 to 1.41	0.48 0.04 to 5.74	0.45 0.14 to 1.55	0.20 0.03 to 1.26
INS_LISPRO	2.46 0.92 to 6.38	20.29 0.63 to 1139	17.08 2.33 to 146	11.77 0.36 to 762	11.94 0.42 to 881	11.97 1.59 to 161	10.79 0.40 to 696	10.11 0.29 to 824	8.83 1.32 to 105	6.88 1.43 to 37.11	5.70 2.05 to 16.19	5.57 1.33 to 24.98	5.43 0.08 to 479	5.43 0.06 to 470	4.53 1.27 to 17.46	4.56 1.66 to 13.51	4.37 0.90 to 22.16	4.24 0.05 to 450	4.33 1.21 to 15.05	4.22 0.05 to 439	4.06 0.05 to 441	3.76 0.05 to 476	3.79 0.51 to 36.49	3.72 0.05 to 395	3.51 0.04 to 422	3.53 0.04 to 387	3.43 0.04 to 453	3.47 0.60 to 23.28	3.55 0.03 to 426	3.34 0.04 to 410	3.38 0.04 to 453	3.44 1.25 to 9.04	2.80 0.80 to 9.11	2.76 0.95 to 7.99	2.69 0.48 to 15.98	2.65 0.82 to 8.36	2.60 0.79 to 8.19	2.54 0.47 to 13.26	2.38 0.71 to 7.87	2.27 0.64 to 7.95	2.19 0.55 to 8.73	2.12 0.61 to 6.91	2.04 0.63 to 6.61	2.02 0.26 to 14.50	1.98 0.86 to 4.50	1.82 0.09 to 37.09	1.40 0.03 to 42.86	1.30 0.06 to 31.68	1.04 0.34 to 3.23	INS_LISPRO	0.96 0.07 to 9.98	0.96 0.18 to 5.00	0.90 0.15 to 5.70	0.91 0.31 to 2.59	0.84 0.24 to 2.86	0.78 0.15 to 3.89	0.63 0.22 to 1.80	0.51 0.04 to 6.75	0.48 0.12 to 1.87	0.21 0.02 to 1.53
COTA_SC_300UG_QD	2.57 0.30 to 29.62	22.26 0.40 to 2177	18.08 1.01 to 408	13.15 0.22 to 1309	13.62 0.24 to 1583	13.17 0.77 to 377	11.96 0.23 to 1240	10.94 0.19 to 1300	9.97 0.51 to 272	7.35 0.57 to 126	6.01 0.56 to 91.48	6.06 0.48 to 97.60	5.78 0.05 to 771	5.67 0.04 to 828	4.81 0.46 to 69.97	4.88 0.43 to 72.02	4.67 0.39 to 71.58	4.68 0.04 to 781	4.50 0.43 to 62.81	4.47 0.04 to 800	4.54 0.04 to 686	4.20 0.03 to 886	4.07 0.26 to 94.19	4.05 0.03 to 745	3.85 0.03 to 725	3.81 0.03 to 680	3.88 0.03 to 653	3.69 0.27 to 70.36	3.66 0.03 to 730	3.69 0.03 to 641	3.68 0.03 to 764	3.56 0.34 to 52.49	2.93 0.29 to 36.03	2.88 0.31 to 35.49	2.82 0.20 to 53.81	2.78 0.31 to 36.14	2.72 0.29 to 35.02	2.63 0.21 to 46.02	2.50 0.25 to 33.02	2.36 0.23 to 31.63	2.30 0.22 to 33.35	2.21 0.23 to 27.41	2.13 0.16 to 40.89	2.11 0.13 to 42.44	2.06 0.20 to 28.57	1.99 0.05 to 84.71	1.45 0.02 to 79.43	1.39 0.04 to 56.87	1.08 0.11 to 13.74	1.05 0.10 to 15.13	COTA_SC_300UG_QD	1.00 0.08 to 16.93	0.94 0.07 to 16.46	0.95 0.10 to 12.31	0.89 0.09 to 11.84	0.83 0.06 to 13.18	0.66 0.07 to 8.75	0.54 0.02 to 15.01	0.50 0.04 to 7.73	0.22 0.01 to 4.73
INS_ASPART	2.59 0.64 to 9.99	21.44 0.57 to 1264	17.47 1.88 to 181	13.03 0.34 to 872	12.63 0.37 to 902	12.64 1.35 to 196	11.41 0.34 to 804	10.59 0.26 to 985	9.48 0.80 to 156	7.20 1.24 to 44.89	6.02 1.07 to 33.32	5.94 0.90 to 36.51	5.39 0.07 to 539	5.51 0.07 to 539	4.79 1.17 to 19.94	4.77 0.87 to 27.39	4.59 0.70 to 30.72	4.60 0.05 to 472	4.47 0.94 to 21.20	4.34 0.05 to 542	4.44 0.05 to 504	4.11 0.04 to 518	3.93 0.52 to 37.03	3.80 0.04 to 433	3.61 0.04 to 466	3.67 0.04 to 480	3.65 0.04 to 516	3.60 0.50 to 29.13	3.48 0.03 to 525	3.49 0.04 to 495	3.48 0.04 to 479	3.58 0.68 to 18.72	2.93 0.62 to 12.70	2.90 0.68 to 12.05	2.82 0.49 to 16.88	2.77 0.67 to 11.19	2.73 0.60 to 11.67	2.65 0.37 to 18.33	2.51 0.77 to 7.89	2.39 0.55 to 10.21	2.31 0.47 to 10.86	2.22 0.47 to 9.57	2.10 0.27 to 15.87	2.10 0.25 to 18.07	2.05 0.40 to 10.34	1.86 0.08 to 49.61	1.46 0.02 to 51.65	1.34 0.06 to 34.24	1.07 0.22 to 5.23	1.04 0.20 to 5.50	1.00 0.06 to 12.97	INS_ASPART	0.95 0.12 to 7.02	0.94 0.21 to 4.17	0.87 0.16 to 4.72	0.80 0.12 to 5.50	0.65 0.14 to 2.99	0.53 0.03 to 7.92	0.49 0.08 to 3.16	0.22 0.02 to 2.10
OTHER_ACTIVE_sulfonylurea	2.74 0.55 to 12.88	23.39 0.58 to 1371	18.71 1.73 to 224	13.25 0.33 to 975	13.33 0.36 to 1082	13.88 1.15 to 223	12.02 0.34 to 979	11.07 0.26 to 1039	10.17 0.80 to 175	7.48 1.07 to 61.60	6.34 0.96 to 40.80	6.20 0.84 to 47.53	5.76 0.07 to 682	5.93 0.06 to 617	5.14 0.82 to 32.04	5.04 0.78 to 32.08	4.80 0.64 to 37.48	4.84 0.05 to 606	4.73 0.78 to 28.64	4.51 0.05 to 601	4.67 0.05 to 553	4.33 0.05 to 634	4.17 0.40 to 56.35	4.00 0.05 to 527	4.09 0.03 to 569	3.92 0.04 to 500	3.93 0.04 to 646	3.80 0.45 to 37.97	3.81 0.03 to 574	3.71 0.04 to 480	3.76 0.03 to 545	3.81 0.61 to 22.18	3.10 0.52 to 17.38	3.03 0.68 to 13.41	2.99 0.35 to 24.81	2.91 0.55 to 14.80	2.88 0.54 to 15.09	2.81 0.34 to 22.49	2.62 0.48 to 15.09	2.54 0.41 to 14.44	2.43 0.40 to 15.05	2.38 0.40 to 12.22	2.27 0.27 to 18.71	2.24 0.20 to 23.37	2.18 0.37 to 12.38	2.03 0.08 to 50.98	1.50 0.02 to 56.26	1.45 0.05 to 39.59	1.15 0.22 to 6.08	1.11 0.18 to 6.63	1.06 0.06 to 14.32	1.05 0.14 to 8.59	OTHER_ACTIVE_sulfonylurea	0.99 0.20 to 5.14	0.92 0.15 to 5.67	0.85 0.10 to 6.60	0.69 0.13 to 3.56	0.55 0.03 to 9.25	0.52 0.07 to 3.70	0.23 0.02 to 2.47
IDEGLIRA_SC_TIT_QD	2.74 1.36 to 5.16	23.11 0.76 to 1150	18.75 2.73 to 151	13.23 0.46 to 823	13.30 0.47 to 869	13.26 1.91 to 156	12.11 0.46 to 762	10.93 0.36 to 755	9.93 1.29 to 124	7.59 1.87 to 35.87	6.28 2.10 to 20.10	6.26 1.55 to 26.45	6.05 0.09 to 549	5.92 0.08 to 472	5.10 1.70 to 15.54	5.05 1.69 to 16.04	4.80 1.32 to 18.96	4.84 0.06 to 494	4.76 1.59 to 14.16	4.61 0.06 to 458	4.55 0.06 to 467	4.31 0.06 to 507	4.20 0.63 to 34.17	4.09 0.05 to 436	3.97 0.04 to 450	3.83 0.05 to 423	3.99 0.04 to 512	3.85 0.75 to 23.45	3.82 0.04 to 453	3.73 0.04 to 420	3.74 0.05 to 488	3.79 1.31 to 10.76	3.10 1.14 to 8.06	3.05 1.53 to 6.09	2.98 0.60 to 15.28	2.95 1.20 to 7.04	2.89 1.15 to 6.99	2.81 0.62 to 12.22	2.66 1.00 to 7.05	2.52 0.91 to 7.24	2.45 0.74 to 8.13	2.36 0.85 to 5.79	2.22 0.50 to 10.93	2.21 0.32 to 14.35	2.18 0.76 to 6.17	2.00 0.10 to 37.53	1.52 0.03 to 43.77	1.41 0.08 to 30.13	1.15 0.58 to 2.35	1.10 0.39 to 3.20	1.05 0.08 to 9.87	1.06 0.24 to 4.65	1.01 0.19 to 5.02	IDEGLIRA_SC_TIT_QD	0.92 0.37 to 2.50	0.86 0.22 to 3.36	0.69 0.37 to 1.29	0.56 0.05 to 6.70	0.52 0.15 to 1.86	0.23 0.03 to 1.28
IGLARLIXI2_SC_TIT_QD	2.96 1.07 to 7.29	24.01 0.73 to 1358	20.05 2.58 to 179	14.07 0.47 to 906	14.32 0.49 to 947	14.35 1.82 to 189	13.10 0.47 to 868	11.95 0.35 to 850	10.78 1.20 to 145	8.08 1.66 to 47.12	6.79 1.78 to 27.45	6.77 1.34 to 33.42	6.52 0.10 to 561	6.40 0.08 to 546	5.49 1.49 to 20.53	5.44 1.45 to 21.20	5.20 1.66 to 17.61	5.18 0.06 to 552	5.08 1.38 to 18.88	4.96 0.06 to 527	4.85 0.06 to 563	4.66 0.06 to 560	4.56 0.63 to 41.68	4.33 0.06 to 477	4.14 0.04 to 526	4.19 0.05 to 464	4.12 0.04 to 548	4.15 0.66 to 28.73	4.12 0.04 to 542	4.08 0.05 to 497	3.92 0.05 to 573	4.09 1.08 to 14.64	3.33 0.96 to 11.13	3.32 1.16 to 8.66	3.19 0.56 to 18.99	3.14 1.00 to 9.85	3.12 0.93 to 9.55	3.03 0.53 to 15.15	2.85 0.85 to 9.45	2.73 0.77 to 9.56	2.64 0.65 to 10.38	2.52 0.71 to 8.10	2.39 0.48 to 12.97	2.40 0.30 to 17.46	2.34 0.74 to 7.62	2.12 0.11 to 45.37	1.62 0.03 to 49.78	1.54 0.07 to 33.46	1.23 0.60 to 2.54	1.19 0.35 to 4.12	1.12 0.08 to 11.58	1.15 0.21 to 6.08	1.09 0.18 to 6.47	1.08 0.40 to 2.72	IGLARLIXI2_SC_TIT_QD	0.92 0.24 to 3.69	0.74 0.24 to 2.20	0.60 0.04 to 7.65	0.57 0.19 to 1.67	0.25 0.03 to 1.79
GLIMEPIRIDE	3.20 0.78 to 12.35	26.58 0.67 to 1645	21.87 2.25 to 236	15.38 0.44 to 1149	15.55 0.42 to 1179	15.59 1.56 to 241	14.22 0.39 to 1016	12.60 0.36 to 1044	11.71 1.01 to 176	8.95 1.30 to 62.29	7.28 1.35 to 41.56	7.30 1.14 to 46.69	7.24 0.09 to 671	6.98 0.07 to 679	5.93 1.16 to 31.66	5.91 1.09 to 33.23	5.72 1.09 to 29.72	5.64 0.06 to 642	5.51 1.09 to 27.46	5.34 0.06 to 662	5.19 0.06 to 629	5.02 0.06 to 681	4.99 0.52 to 54.27	4.82 0.05 to 581	4.52 0.05 to 676	4.55 0.05 to 577	4.49 0.04 to 666	4.50 0.55 to 39.39	4.51 0.04 to 623	4.41 0.05 to 584	4.27 0.04 to 643	4.44 0.85 to 22.70	3.65 0.74 to 16.85	3.57 0.85 to 14.46	3.46 0.47 to 27.09	3.44 0.75 to 15.31	3.39 0.72 to 15.18	3.28 0.46 to 22.29	3.10 0.63 to 14.43	2.98 0.59 to 14.45	2.90 0.49 to 15.60	2.74 0.54 to 12.53	2.66 0.38 to 18.43	2.60 0.25 to 23.17	2.55 0.51 to 12.24	2.31 0.10 to 58.50	1.75 0.03 to 64.48	1.68 0.07 to 45.11	1.35 0.41 to 4.31	1.28 0.26 to 6.81	1.21 0.08 to 15.40	1.25 0.18 to 8.44	1.18 0.15 to 9.60	1.16 0.30 to 4.57	1.09 0.27 to 4.23	GLIMEPIRIDE	0.80 0.19 to 3.50	0.63 0.04 to 10.26	0.61 0.12 to 3.15	0.27 0.03 to 2.37
INS_DEGLUDEC	3.95 1.77 to 8.24	33.15 1.10 to 1786	26.85 3.80 to 230	19.17 0.67 to 1212	19.32 0.68 to 1325	19.02 2.67 to 251	17.10 0.66 to 1096	16.00 0.51 to 1201	14.27 1.79 to 171	10.86 2.54 to 53.68	9.07 3.16 to 27.56	8.98 2.34 to 39.65	8.74 0.13 to 760	8.63 0.11 to 737	7.32 2.36 to 23.10	7.31 2.54 to 21.11	7.01 1.72 to 29.87	6.78 0.09 to 680	6.82 2.25 to 21.13	6.66 0.09 to 690	6.43 0.09 to 695	6.21 0.08 to 785	6.13 0.87 to 50.98	5.93 0.08 to 645	5.70 0.06 to 642	5.64 0.07 to 616	5.72 0.06 to 740	5.59 1.04 to 34.53	5.46 0.06 to 665	5.37 0.06 to 650	5.42 0.06 to 674	5.49 1.98 to 15.00	4.48 1.56 to 12.42	4.39 2.02 to 9.60	4.32 0.86 to 23.97	4.25 1.60 to 11.07	4.17 1.55 to 11.06	4.06 0.82 to 19.47	3.81 1.37 to 10.84	3.65 1.18 to 11.16	3.52 1.03 to 12.20	3.41 1.17 to 9.27	3.22 0.72 to 15.63	3.21 0.44 to 21.54	3.15 1.05 to 9.08	2.90 0.15 to 57.45	2.21 0.04 to 63.52	2.05 0.11 to 43.05	1.66 0.71 to 3.96	1.59 0.56 to 4.57	1.52 0.11 to 14.69	1.53 0.33 to 7.24	1.45 0.28 to 7.67	1.45 0.78 to 2.68	1.35 0.46 to 4.08	1.24 0.29 to 5.19	INS_DEGLUDEC	0.81 0.06 to 9.83	0.75 0.20 to 3.00	0.34 0.05 to 2.06
LIRA_SC_0p9MG_QD	4.81 0.45 to 57.10	41.90 0.69 to 3883	33.96 1.65 to 782	24.56 0.38 to 2542	25.23 0.40 to 2962	25.01 1.18 to 695	22.47 0.39 to 2708	20.06 0.33 to 2632	18.53 0.77 to 536	13.54 0.97 to 232	11.28 0.85 to 168	11.29 0.75 to 175	11.21 0.09 to 1507	10.69 0.08 to 1577	8.96 0.71 to 124	8.89 0.66 to 129	8.84 0.59 to 139	8.65 0.06 to 1389	8.45 0.66 to 114	8.29 0.06 to 1507	8.26 0.07 to 1281	7.37 0.07 to 1423	7.62 0.41 to 184	7.35 0.05 to 1284	6.92 0.05 to 1575	7.11 0.05 to 1525	7.13 0.05 to 1462	6.90 0.44 to 139	7.09 0.04 to 1266	6.83 0.05 to 1142	6.72 0.05 to 1335	6.67 0.52 to 92.47	5.48 0.49 to 66.33	5.45 0.46 to 68.91	5.40 0.32 to 94.77	5.21 0.47 to 66.34	5.09 0.47 to 59.32	4.96 0.33 to 82.86	4.66 0.39 to 60.60	4.47 0.38 to 59.75	4.36 0.33 to 63.45	4.10 0.36 to 50.83	4.00 0.24 to 70.09	3.95 0.19 to 85.02	3.86 0.31 to 52.36	3.60 0.09 to 154	2.72 0.03 to 171	2.55 0.07 to 110	2.07 0.17 to 26.34	1.97 0.15 to 26.76	1.86 0.07 to 48.66	1.90 0.13 to 31.15	1.81 0.11 to 30.90	1.79 0.15 to 22.13	1.66 0.13 to 23.28	1.59 0.10 to 24.51	1.24 0.10 to 16.34	LIRA_SC_0p9MG_QD	0.92 0.07 to 14.48	0.41 0.02 to 8.45
INS_PREMIX	5.21 1.52 to 17.56	43.77 1.26 to 2742	36.45 3.92 to 350	24.81 0.73 to 1703	25.34 0.83 to 1863	25.66 2.84 to 383	22.70 0.76 to 1565	21.31 0.58 to 1615	19.14 2.00 to 278	14.48 2.50 to 90.83	12.05 2.61 to 57.59	11.93 2.06 to 68.43	11.51 0.16 to 1081	11.01 0.14 to 1075	9.74 2.16 to 42.65	9.63 2.07 to 44.34	9.28 1.95 to 43.46	9.15 0.11 to 1004	9.07 2.02 to 39.28	8.88 0.11 to 938	8.62 0.10 to 957	8.10 0.10 to 1001	8.13 0.91 to 82.80	7.48 0.10 to 899	7.53 0.07 to 929	7.31 0.08 to 840	7.45 0.07 to 1047	7.44 1.00 to 58.55	7.35 0.07 to 1024	7.20 0.08 to 882	6.99 0.08 to 1091	7.20 1.60 to 32.46	5.91 1.34 to 25.11	5.87 1.58 to 20.59	5.72 0.83 to 38.81	5.65 1.38 to 22.59	5.50 1.31 to 21.95	5.41 0.85 to 32.79	5.09 1.18 to 20.78	4.88 1.05 to 20.70	4.69 0.91 to 22.45	4.52 0.98 to 18.28	4.30 0.74 to 26.58	4.27 0.44 to 33.86	4.16 1.17 to 14.32	3.79 0.17 to 91.65	2.99 0.05 to 96.20	2.75 0.12 to 62.63	2.20 0.64 to 7.17	2.10 0.54 to 8.60	2.00 0.13 to 23.72	2.05 0.32 to 12.65	1.92 0.27 to 13.50	1.93 0.54 to 6.58	1.77 0.60 to 5.25	1.63 0.32 to 8.65	1.33 0.33 to 4.94	1.09 0.07 to 14.99	INS_PREMIX	0.44 0.04 to 3.66
OTHER_ACTIVE_basal_bolus_insulin	11.72 1.91 to 84.80	102 2.10 to 7660	80.39 6.01 to 1238	57.20 1.34 to 5371	59.80 1.35 to 4687	59.54 4.29 to 1181	53.28 1.25 to 4683	48.74 1.00 to 4511	44.27 3.03 to 919	32.82 3.66 to 356	27.30 3.35 to 245	26.58 2.99 to 279	25.83 0.28 to 3311	25.26 0.25 to 3046	21.97 2.91 to 181	21.74 2.79 to 197	20.85 2.46 to 210	20.59 0.18 to 3287	20.31 2.80 to 170	19.87 0.18 to 2798	19.64 0.20 to 2912	18.86 0.19 to 2656	18.20 1.49 to 294	17.85 0.18 to 2383	17.23 0.14 to 2801	17.03 0.16 to 2509	16.53 0.15 to 2934	16.84 1.51 to 210	16.42 0.12 to 2834	16.35 0.14 to 2583	16.22 0.13 to 2952	16.19 2.25 to 145	13.34 1.88 to 108	13.07 2.18 to 94.00	13.01 1.20 to 152	12.70 1.88 to 96.63	12.35 1.84 to 99.87	12.11 1.28 to 133	11.35 1.63 to 91.31	10.88 1.51 to 90.71	10.64 1.37 to 93.10	10.28 1.43 to 78.41	9.61 1.00 to 111	9.59 0.75 to 132	9.51 1.30 to 76.92	8.78 0.27 to 299	6.43 0.09 to 299	6.35 0.23 to 182	4.94 0.80 to 36.07	4.71 0.66 to 40.24	4.56 0.21 to 83.27	4.59 0.48 to 47.08	4.35 0.40 to 52.19	4.30 0.78 to 28.89	4.06 0.56 to 31.12	3.72 0.42 to 35.98	2.96 0.49 to 21.62	2.42 0.12 to 54.05	2.25 0.27 to 23.01	OTHER_ACTIVE_basal_bolus_insulin

Heterogeneity, fit and convergence

Bayesian random effects (primary)

Heterogeneity (tau): 0.584 (95% CrI 0.412 to 0.813), log scale
Residual deviance: 182.4 for 204 data points
DIC: 305.1 (pD 122.7)
Largest R-hat: 1.002
Smallest ESS: bulk 1,848, tail 2,807
Divergent transitions: 0
Convergence: All criteria met
Priors: PR02 N(0, 5^2); PR05 N(0, 2.5^2); PR09 log normal(-2.1, 1.58^2) on tau^2 (Adverse events, pharm vs pharm)

Inconsistency

Do trials comparing two treatments directly agree with the indirect evidence through other treatments?

No comparison here has both direct and indirect evidence, so inconsistency cannot be checked by node splitting.

Small study effects

A comparison adjusted funnel plot: each point is one trial comparison, centered on its own network estimate. Asymmetry can signal that small trials with unfavorable results are missing.

Fewer than ten trial comparisons, too few to judge funnel plot asymmetry.

Baseline characteristics of the trials

The baseline value of each effect modifier or prognostic factor that applies here, per trial: mean or percent over arms, weighted by the number randomized. A note under a value names a stand in (a median for a mean, 100 minus the male share, Asian subgroup rows, an all Asian site list); "not reported" means no source of the trial prints it.

Baseline effect modifiers and prognostic factors per trial
Trial	Baseline HbA1c (percent) effect modifier, prognostic factor; 74 of 75	Background glucose lowering therapy (stratum S0 to S4) effect modifier, prognostic factor; 71 of 75
AWARD-11 S000046	8.6	S1
NCT02325960 S000058	8.18	S1
DUAL™ I China S000081	8.23	S1
SURPASS-6 S000108	8.8	S2
PIONEER 4 S000133	7.98	S1
NCT04965506 S000140	8.05	S4
COMBINE 2 S000155	8	S1
STEP HFpEF DM S000161	6.8 median	S4
DUAL™IV S000164	7.9	S1
Lixilan-O-AP S000170	8.34	S1
PB119 S000217	8.5	S0
PIONEER 10 S000234	8.31	S1
SUSTAIN™ 3 S000329	8.34	S1
NCT00765817 S000345	8.4	S2
SUSTAIN 11 S000363	8.55	S2
SUSTAIN 7 S000372	8.23	S1
NCT00637273 S000402	8.53	S1
PIONEER 12 S000522	8.12	S1
SUSTAIN 10 S000584	8.2	S1
NCT00960661 S000609	8.25	S2
NCT02008682 S000650	8.12	S1
PREVAIL S000693	6.57	S2
NCT02229383 S000703	8.53	S2
NCT00434954 S000790	7.89	S1
GRADE S000873	7.5	S1
NCT05759897 S000877	8.52	S1
NCT01617434 S000926	8.25	S2
LIRA-Ramadan™ S000963	8.25	S1
AWARD-8 S001068	8.4	S1
LIRA-SWITCH™ S001119	8.25	S1
DURATION-NEO-2 S001157	8.45	S1
AWARD-6 S001184	8.05	S1
LixiLan-O S001199	8.1	S1
NCT06974825 S001200	8.09	S0
DUALTM IX S001236	8.3	S1
SUSTAIN S001311	8.1	S1
DUAL™ V S001328	8.3	S2
NCT01003184 S001355	8.36	S1
NCT03861039 S001385	8.56	S1
SUSTAIN™ S001498	8.06	S4
NCT05486065 S001555	8.35	S1
DUAL™ II China S001556	8.94	S2
SURPASS-3 S001591	8.17	S1
PIONEER 1 S001741	not reported	S0
NCT01126580 S001786	7.6	S0
PIONEER 11 S001791	7.95	S0
SUSTAIN™ 5 S001872	8.37	S2
NCT02229227 S001887	7.7	S3
SURPASS-SWITCH S001940	7.82	not reported
PIONEER 9 S001943	8.2	S0
DUAL™ I Japan S001965	8.43	S1
NCT00676338 S001966	8.53	S0
PIONEER 5 S002025	7.95	S4
DUAL™ II Japan S002038	8.58	S2
NCT03550378 S002039	7.86	S4
SUSTAIN™ S002082	8.13	S0
LEAD-5 S002098	8.26	S1
Lixilan-L-CN S002110	8.3	S2
NCT05767255 S002117	11.6	S0
NCT04998032 S002121	8.66	S1
NCT02505334 S002164	8.12	S0
NCT01455441 S002225	8.11	S1
NCT03311724 S002256	8.38	S1
PIONEER 3 S002267	8.33	S1
NCT04466904 S002331	8.7	S4
NCT00700817 S002361	8.43	S1
PIONEER 8 S002369	8.2	S4
NCT06256523 S002776	8.12	not reported
S002928 S002928	7.3 median	S1
S002946 S002946	6.45	S1
S002951 S002951	8.75	not reported
S002969 S002969	6.74 median	S1
S002992 S002992	8.6	S2
S003050 S003050	7.15	S1
S003072 S003072	8	not reported

Comparability of the trials

Checked across designs (the set of treatments each trial compares) for eligibility, outcome definition and assessment, and the baseline factors above. Flags point to possible intransitivity; notes describe variation that is not tied to design.

FlagBaseline, Baseline HbA1c: design means range from 6.5 (DULA_SC_0p75MG_QW vs SEMA_SC_0p5MG_QW) to 11.6 (IDEGLIRA_SC_TIT_QD vs OTHER_ACTIVE_basal_bolus_insulin) percent; threshold 0.5
FlagEligibility, hba1c entry range: a design requires hba1c 8 or more while another admits only 7.5 or less
FlagEligibility, bmi entry range: a design requires bmi 50 or more while another admits only 30 or less
NoteOutcome assessment, time point: selected time points span 4 to 386.13 weeks
NoteOutcome assessment, analysis set: mixed: completers 2, full_analysis 4, modified_itt 10, other 2, per_protocol 1, randomized 1, safety 55
NoteOutcome assessment, definition: mixed: ADA 2018 level 2 (below 3.0 mmol/L); level 3 row zero in all arms 1, ADA 2018 level 2, glucose below 3.0 mmol/L; level 3 printed as zero in all arms 1, ADA level 2 (below 3.0 mmol/L) or level 3 (external assistance) 1, CGM glucose below 3.0 mmol/L for over 15 minutes 1, clinically important, symptoms with plasma glucose below 54 mg/dL 1, confirmed minor (plasma glucose below 3.1 mmol/L) or severe hypoglycemia 1, confirmed: severe or plasma glucose below 3.1 mmol/L 2, documented below 3.0 mmol/L regardless of symptoms (ADA level 2) 1, documented plasma glucose below 3.0 mmol/L regardless of symptoms 1, documented, confirmed plasma glucose below 54 mg/dL 1, glucose below 3.0 mmol/L or severe hypoglycemia 1, glucose below 3.0 mmol/L; no severe events in any arm 1, glucose below 54 mg/dL or level 3 1, glucose below 54 mg/dL or severe hypoglycemia 1, glucose below 54 mg/dL or severe, excluding events after new antihyperglycemic therapy 1, hypoglycemia below 3.0 mmol/L or requiring assistance 1, level 2 hypoglycemia, glucose below 54 mg/dL 1, measured glucose below 54 mg/dL in 30 days before any quarterly visit 1, minor (symptomatic, glucose below 54 mg/dL) or major hypoglycemia 1, Minor confirmed: symptoms with glucose below 3.0 mmol/L, self treated 1, minor hypoglycemia, plasma glucose below 3.1 mmol/L 1, minor, self treated with plasma glucose below 3.1 mmol/L 1, minor: symptomatic, glucose below 3.0 mmol/L, not major 1, minor: symptoms with glucose below 3 mmol/L, self treated or resolved 1, minor: symptoms with glucose below 3.0 mmol/L, self treated 1, No severe or below 3 mmol/L hypoglycemia over whole 52 week study 1, not stated 25, participants whose worst on therapy event had glucose below 3.1 mmol/L 1, participants with capillary glucose 3.0 mmol/L or lower 1, plasma glucose 54 mg/dL or lower 1, plasma glucose below 3.0 mmol/L with or without symptoms 1, severe (ADA) or blood glucose confirmed below 3.1 mmol/L with symptoms 2, Severe (ADA) or blood glucose confirmed below 3.1 mmol/L with symptoms 1, Severe (ADA) or glucose confirmed below 3.1 mmol/L with symptoms 1, severe (ADA) or plasma glucose confirmed below 3.1 mmol/L 1, severe (ADA) or symptomatic with plasma glucose below 3.1 mmol/L 1, severe by ADA or plasma glucose below 3.1 mmol/L with symptoms 1, severe or blood glucose confirmed below 3.1 mmol/L 1, severe or blood glucose confirmed below 3.1 mmol/L with or without symptoms 1, severe or blood glucose confirmed symptomatic below 3.1 mmol/L 2, severe or blood glucose confirmed symptomatic hypoglycemia 3, Severe or plasma glucose below 3.1 mmol/L 1, severe or plasma glucose confirmed below 3.1 mmol/L 1, treatment emergent confirmed hypoglycemia, PG below 3.1 mmol/L or unable to self treat 1, Zero implied by no hypoglycemia episodes of any kind 1, Zero implied by no hypoglycemia of any kind 1
NoteOutcome assessment, proportion method: mixed: not stated 62, observed 13
NoteOutcome assessment, intercurrent events (discontinuation): mixed: hypothetical 1, not stated 71, while_on_treatment 3
NoteOutcome assessment, intercurrent events (rescue): mixed: hypothetical 3, not stated 70, treatment_policy 2
NoteRisk of bias, blinding: mixed: double_blind 36, not_reported 1, open_label 35, single_blind 3
NoteRisk of bias, funding: mixed: industry 66, mixed 3, non_industry 5, not_reported 1
NoteData handling, input conversions: arms_combined 1, count_from_percent 32, printed_denominator 9

Comparability items per trial
Trial	time weeks	analysis set	definition	instrument	adjudicated	proportion method	intercurrent events (discontinuation)	intercurrent events (rescue)	blinding	funding	start year	Eligibility
AWARD-11	52	safety	documented, confirmed plasma glucose below 54 mg/dL	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2018	age 18 or older; HbA1c 7.5 to 11.0%; BMI 25 or more; metformin 1500 mg/day or more; GLP-1 RA and insulin naive
NCT02325960	16	safety	not stated	not stated	not stated	not stated	not stated	not stated	open_label	mixed	2015	age 18 to 70; BMI 24 or more; HbA1c 7.0 to 10.0 percent; metformin 1.5 g/day or more
DUAL™ I China	27	safety	severe or blood glucose confirmed below 3.1 mmol/L	not stated	not stated	not stated	not stated	not stated	open_label	industry	2017	Chinese adults 18 y or older; HbA1c 7.0 to 10.0; BMI 40 or less; metformin with or without one OAD
SURPASS-6	56	safety	glucose below 54 mg/dL or severe hypoglycemia	not stated	not stated	not stated	while_on_treatment	hypothetical	open_label	industry	2020	adults 18 or older; HbA1c 7.5 to 11 percent; BMI 23 to 45; basal insulin at least 30 U/day with or without up to 2 oral drugs
PIONEER 4	57	safety	not stated	not stated	not stated	not stated	while_on_treatment	treatment_policy	double_blind	industry	2016	Age 18 or older; T2D on metformin with or without SGLT2i; HbA1c 7.0 to 9.5 percent; eGFR 60 or more
NCT04965506	24	safety	glucose below 3.0 mmol/L; no severe events in any arm	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2021	age 18 to 75; HbA1c 7.0 to 10.5 percent; BMI 20 to under 40; diet or metformin
COMBINE 2	57	safety	not stated	not stated	not stated	not stated	not stated	not stated	open_label	industry	2022	adults T2D on GLP-1 RA with or without oral drugs; HbA1c 7.0 to 10.0 percent
STEP HFpEF DM	57	safety	ADA level 2 (below 3.0 mmol/L) or level 3 (external assistance)	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2021	age 18 or older; heart failure with LVEF 45% or more; BMI 30 or more; type 2 diabetes with HbA1c 10% or less
DUAL™IV	27	safety	not stated	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2012	adults 18 or older; HbA1c 7.0 to 9.0 percent; BMI 40 or less; SU with or without metformin; insulin and GLP-1 RA naive
Lixilan-O-AP	24.43	safety	documented plasma glucose below 3.0 mmol/L regardless of symptoms	not stated	not stated	not stated	not stated	not stated	open_label	industry	2019	adults with T2D on metformin with or without a second OAD; HbA1c 7.5 to 11 percent, or 7 to 10 percent with a non SGLT2i second OAD
PB119	24	safety	No severe or below 3 mmol/L hypoglycemia over whole 52 week study	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2020	age 18 to 75; HbA1c 7.5 to 11.0 at screening and 7.0 to 10.5 at randomization; BMI 18.5 to 40; eGFR 60 or more; drug naive
PIONEER 10	57	safety	severe (ADA) or blood glucose confirmed below 3.1 mmol/L with symptoms	not stated	not stated	not stated	while_on_treatment	treatment_policy	single_blind	industry	2017	Japanese adults 20 or older; T2D; HbA1c 7.0 to 10.5 percent on one oral glucose lowering drug
SUSTAIN™ 3	61	safety	severe (ADA) or blood glucose confirmed below 3.1 mmol/L with symptoms	not stated	not stated	observed	not stated	not stated	open_label	industry	2013	age 18 or older; T2D on stable 1 to 2 oral drugs; HbA1c 7.0 to 10.5 percent; eGFR 60 or more
NCT00765817	30	full_analysis	minor: symptoms with glucose below 3 mmol/L, self treated or resolved	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2008	adults 18 or older; insulin glargine 20 U/d or more alone or with metformin or pioglitazone; HbA1c 7.1 to 10.5 percent; BMI 45 or less
SUSTAIN 11	52	full_analysis	not stated	not stated	not stated	not stated	not stated	not stated	open_label	industry	2018	adults; HbA1c above 7.5 to 10.0 percent on insulin glargine plus metformin
SUSTAIN 7	45	safety	not stated	not stated	not stated	observed	not stated	not stated	open_label	industry	2016	age 18 or older; HbA1c 7.0 to 10.5 percent; eGFR 60 or higher; metformin background
NCT00637273	26	modified_itt	not stated	not stated	not stated	observed	not stated	not stated	double_blind	industry	2008	age 18 or older; HbA1c 7.1 to 11.0 percent; BMI 25 to 45; stable metformin
PIONEER 12	31	safety	ADA 2018 level 2, glucose below 3.0 mmol/L; level 3 printed as zero in all arms	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2019	adults with type 2 diabetes on metformin, HbA1c 7.0 to 10.5 percent
SUSTAIN 10	35	safety	severe or blood glucose confirmed symptomatic hypoglycemia	not stated	not stated	not stated	not stated	not stated	open_label	industry	2017	adults with T2D, HbA1c 7.0 to 11.0 percent on 1 to 3 oral drugs
NCT00960661	30	other	minor: symptoms with glucose below 3.0 mmol/L, self treated	not stated	not stated	observed	not stated	not stated	open_label	industry	2009	age 18 or older; T2D on insulin glargine and metformin with or without sulfonylurea; HbA1c 7.0 to 10.0; BMI 25.0 (23.0 in South Korea) to 45.0; HbA1c above 7.0 after optimization
NCT02008682	26	safety	Severe or plasma glucose below 3.1 mmol/L	not stated	not stated	not stated	not stated	not stated	open_label	industry	2013	Chinese adults 18 to 80; HbA1c 7.0 to 10.0 on metformin; BMI 45 or lower
PREVAIL	20	modified_itt	participants with capillary glucose 3.0 mmol/L or lower	not stated	not stated	not stated	not stated	not stated	open_label	non_industry	2014	age 30 to 80; T2D 7 years or less; A1c 6.0 to 9.5 percent off drugs or 5.5 to 9.0 on up to 2 oral drugs
NCT02229383	38	safety	minor: symptomatic, glucose below 3.0 mmol/L, not major	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2014	adults; insulin glargine 20 U/d or more with or without metformin; HbA1c 7.0 to 10.5 percent at randomization
NCT00434954	26	full_analysis	not stated	not stated	not stated	observed	not stated	not stated	open_label	industry	2007	adults with T2D on metformin, HbA1c 6.5 to 10.0 percent
GRADE	386.13	per_protocol	measured glucose below 54 mg/dL in 30 days before any quarterly visit	not stated	not stated	not stated	hypothetical	hypothetical	single_blind	mixed	2013	age at diagnosis 30 or older; T2D under 10 years; HbA1c 6.8 to 8.5 percent; metformin 1000 mg/day or more
NCT05759897	16	safety	not stated	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2023	age 18 to 75; BMI 19.0 to 40.0; HbA1c 7.5 to 11.0 on stable metformin
NCT01617434	27	safety	confirmed minor (plasma glucose below 3.1 mmol/L) or severe hypoglycemia	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2012	age 18 to 80; HbA1c 7.0 to 10.0 percent; BMI 20 to 45; basal insulin analogue 20 U or more with or without metformin
LIRA-Ramadan™	30	safety	confirmed: severe or plasma glucose below 3.1 mmol/L	not stated	not stated	not stated	not stated	not stated	open_label	industry	2014	age 18 to 80; HbA1c 7 to 10 percent; BMI 20 or more; metformin plus sulfonylurea; intent to fast in Ramadan
AWARD-8	24	modified_itt	plasma glucose below 3.0 mmol/L with or without symptoms	not stated	not stated	not stated	not stated	hypothetical	double_blind	industry	2013	age 18 or older; BMI up to 45; HbA1c 7.5 to 9.5 percent on sulfonylurea at least half maximal dose
LIRA-SWITCH™	27	safety	confirmed: severe or plasma glucose below 3.1 mmol/L	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2013	age 18 or more; HbA1c 7.5 to 9.5 percent; BMI 20 or more; on sitagliptin 100 mg and metformin for 90 days or more
DURATION-NEO-2	28	safety	minor (symptomatic, glucose below 54 mg/dL) or major hypoglycemia	not stated	not stated	not stated	not stated	not stated	open_label	industry	2013	age 18 or older; HbA1c 7.1 to 11.0 percent; BMI 45 or lower; metformin 1500 mg or more
AWARD-6	26	modified_itt	glucose below 3.0 mmol/L or severe hypoglycemia	not stated	not stated	observed	not stated	not stated	open_label	industry	2012	adults; HbA1c 7 to 10 percent; metformin 1500 mg/day or more
LixiLan-O	30.14	safety	clinically important, symptoms with plasma glucose below 54 mg/dL	not stated	not stated	not stated	not stated	not stated	open_label	industry	2014	adults; HbA1c 7.5 to 10% on metformin or 7 to 9% on metformin plus second OAD; 7 to 10% after run in
NCT06974825	20	safety	not stated	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2023	age 18 to 65; HbA1c 7.0 to 10.0 percent; BMI 19.5 to 35.0; no glucose lowering drug for 8 weeks
DUALTM IX	26	safety	severe or blood glucose confirmed symptomatic below 3.1 mmol/L	not stated	not stated	observed	not stated	not stated	open_label	industry	2016	adults; insulin naive type 2 diabetes on SGLT2 inhibitor with or without other oral drugs; HbA1c 7.0 to 11.0 percent; BMI 20 to 40
SUSTAIN	35	safety	Severe (ADA) or glucose confirmed below 3.1 mmol/L with symptoms	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2017	Adults 18 or older, HbA1c 7.0 to 10.5 percent on metformin monotherapy, eGFR 60 or more
DUAL™ V	26	safety	treatment emergent confirmed hypoglycemia, PG below 3.1 mmol/L or unable to self treat	not stated	not stated	not stated	not stated	not stated	open_label	industry	2013	T2D uncontrolled on insulin glargine 20 to 50 U plus metformin
NCT01003184	26	modified_itt	not stated	not stated	not stated	not stated	not stated	not stated	open_label	industry	2009	age 18 or older; HbA1c 7.1 to 10.0 percent; BMI 25 to 45; metformin with or without SU
NCT03861039	56	modified_itt	glucose below 54 mg/dL or severe, excluding events after new antihyperglycemic therapy	not stated	not stated	not stated	not stated	not stated	open_label	industry	2019	Japanese adults 20 y or older; BMI 23 or more; on OAM monotherapy
SUSTAIN™	62	safety	severe (ADA) or symptomatic with plasma glucose below 3.1 mmol/L	not stated	not stated	not stated	not stated	not stated	open_label	industry	2014	Japanese adults 20 or older; HbA1c 7.0 to 10.5 percent; diet and exercise or OAD monotherapy; eGFR 30 or more
NCT05486065	49	safety	not stated	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2022	age 18 to 64; HbA1c 7.0 to 10.5; BMI 27 or more; on metformin
DUAL™ II China	26	safety	severe or plasma glucose confirmed below 3.1 mmol/L	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2017	age 18 or older; BMI 24 or higher; HbA1c 7.5 or higher; basal insulin 20 to 50 U plus metformin
SURPASS-3	56	safety	glucose below 54 mg/dL or level 3	not stated	not stated	not stated	not stated	not stated	open_label	industry	2019	insulin naive; HbA1c 7.0 to 10.5 percent; BMI at least 25; metformin with or without SGLT2i; eGFR above 45
PIONEER 1	31	safety	severe or blood glucose confirmed symptomatic hypoglycemia	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2016	adults with type 2 diabetes on diet and exercise only; HbA1c 7.0 to 9.5 percent
NCT01126580	26	modified_itt	not stated	not stated	not stated	observed	not stated	not stated	double_blind	industry	2010	type 2 diabetes on diet and exercise or one oral drug; registry gives no ranges
PIONEER 11	31	safety	ADA 2018 level 2 (below 3.0 mmol/L); level 3 row zero in all arms	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2019	age 18 or older; HbA1c 7.0 to 10.0 percent at screening, 7.0 to 9.5 at randomization; no glucose lowering drugs; eGFR 60 or more
SUSTAIN™ 5	35	safety	not stated	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2014	age 18 or older (20 in Japan); HbA1c 7.0 to 10.0 percent; stable basal insulin with or without metformin; eGFR 30 or more
NCT02229227	26	safety	participants whose worst on therapy event had glucose below 3.1 mmol/L	not stated	not stated	not stated	not stated	not stated	open_label	industry	2014	age 18 to 75; HbA1c 7.0 to 9.5 percent at screening; BMI 40 or less; basal plus prandial insulin
SURPASS-SWITCH	44	modified_itt	level 2 hypoglycemia, glucose below 54 mg/dL	not stated	not stated	observed	not stated	not stated	open_label	industry	2022	age 18 or older; HbA1c 7.0 to 9.5 percent; BMI 25 or more; stable dulaglutide 0.75 or 1.5 mg
PIONEER 9	57	safety	Severe (ADA) or blood glucose confirmed below 3.1 mmol/L with symptoms	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2017	Japanese adults 20 y or older; HbA1c 6.5 to 9.5 on one oral drug washed out, or 7.0 to 10.0 on diet and exercise
DUAL™ I Japan	53	safety	severe or blood glucose confirmed below 3.1 mmol/L with or without symptoms	not stated	not stated	not stated	not stated	not stated	open_label	industry	2015	Japanese adults 20 or older; HbA1c 7.0 to 11.0 percent; BMI at least 20; insulin naive on one oral drug
NCT00676338	26	full_analysis	Minor confirmed: symptoms with glucose below 3.0 mmol/L, self treated	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2008	adults, HbA1c 7.1 to 11.0 percent, BMI 23 to 45 kg/m2, drug naive
PIONEER 5	31	safety	severe or blood glucose confirmed symptomatic hypoglycemia	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2016	type 2 diabetes; HbA1c 7.0 to 9.5 percent; moderate renal impairment
DUAL™ II Japan	27	safety	severe (ADA) or plasma glucose confirmed below 3.1 mmol/L	not stated	not stated	observed	not stated	not stated	double_blind	industry	2016	Japanese adults; BMI 23 kg/m2 or more; HbA1c 7.5 to 11.0 percent; basal or premix insulin 20 to 50 U with metformin
NCT03550378	8.43	safety	not stated	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2018	age 18 to 84; BMI 25 to 45; eGFR 30 to 59; HbA1c 6.5 to 10.5 percent
SUSTAIN™	35	safety	severe by ADA or plasma glucose below 3.1 mmol/L with symptoms	not stated	not stated	not stated	not stated	not stated	open_label	industry	2014	Japanese; age 20 or older; HbA1c 6.5 to 9.5 percent on one OAD or 7.0 to 10.5 percent on diet and exercise
LEAD-5	26	safety	minor hypoglycemia, plasma glucose below 3.1 mmol/L	not stated	not stated	observed	not stated	not stated	double_blind	industry	2006	age 18 to 80; HbA1c 7.5 to 10 on monotherapy or 7 to 10 on combination; BMI 45 or lower
Lixilan-L-CN	30	safety	documented below 3.0 mmol/L regardless of symptoms (ADA level 2)	not stated	not stated	not stated	not stated	not stated	open_label	industry	2019	Chinese adults; HbA1c 7.0 to 10.5 percent; basal insulin 10 to 25 U/day with up to 2 oral drugs; FPG at most 8.9 mmol/L
NCT05767255	4	modified_itt	CGM glucose below 3.0 mmol/L for over 15 minutes	not stated	not stated	observed	not stated	not stated	open_label	non_industry	2022	adults hospitalized with T2D needing MDI; HbA1c 8.0 to 15 percent; eGFR 15 or more
NCT04998032	24	safety	not stated	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2021	age 18 to 75; metformin monotherapy; HbA1c 7.5 to 10.5 at randomization; BMI 18.5 to 40; eGFR 60 or higher
NCT02505334	26	safety	not stated	not stated	not stated	not stated	not stated	not stated	open_label	industry	2015	Japanese adults on one oral drug, HbA1c 7.5 to 10.0 percent; randomized if HbA1c 7.0 or more after run in
NCT01455441	16	completers	Zero implied by no hypoglycemia episodes of any kind	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2011	age over 18; HbA1c 7 to 11 percent; BMI over 25; diet or metformin; sedentary
NCT03311724	16	modified_itt	plasma glucose 54 mg/dL or lower	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2017	age 18 to 75; T2D at least 6 months; HbA1c 7.0 to 10.5%; BMI 23 to 45; diet or stable metformin
PIONEER 3	83	safety	severe or blood glucose confirmed symptomatic below 3.1 mmol/L	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2016	adults with T2D; HbA1c 7.0 to 10.5 percent; metformin with or without sulfonylurea
NCT04466904	20	safety	not stated	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2020	age 18 to 75; T2D on diet and exercise or stable metformin; HbA1c 7.5 to 11.0 percent; BMI 20 to 35
NCT00700817	52	other	minor, self treated with plasma glucose below 3.1 mmol/L	not stated	not stated	observed	not stated	not stated	open_label	industry	2008	age 18 to 80; HbA1c 7.5 to 10%; BMI 45 or less; metformin 1500 mg/day or more for 3 months
PIONEER 8	57	safety	not stated	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2017	adults with type 2 diabetes on basal, premixed or basal bolus insulin with or without metformin
NCT06256523	29	safety	not stated	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2022	age 18 to 65; HbA1c 7.0 to 10.0 percent; BMI 18.5 to 35; eGFR 60 or more
S002928	24	safety	hypoglycemia below 3.0 mmol/L or requiring assistance	not stated	not stated	not stated	not stated	not stated	single_blind	non_industry	2022	age 18 to 65; BMI 50 or more; type 2 diabetes
S002946	26	randomized	Zero implied by no hypoglycemia of any kind	not stated	not stated	not stated	not stated	not stated	open_label	not_reported	2020	age over 20; T2D on liraglutide 0.6 or 0.9 mg; no new diabetes drug for 3 months
S002951	16	safety	not stated	not stated	not stated	not stated	not stated	not stated	open_label	non_industry	2022	age 18 to 65; BMI 25 or more; HbA1c 7.0 to 10.0 percent; lifestyle or one OAD
S002969	52.14	safety	not stated	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2018	age 18 to 70; BMI 30 to 50; HbA1c 48 to below 97 mmol/mol; T2DM under 10 years; undergoing LAGB
S002992	26	safety	not stated	not stated	not stated	not stated	not stated	not stated	open_label	industry		adults 18 or older; HbA1c 7.5 to 10 percent; BMI 20 to less than 40; basal insulin 20 to 50 U plus metformin with or without SGLT2i
S003050	12	safety	not stated	not stated	not stated	not stated	not stated	not stated	not_reported	non_industry	2020	age 18 to 65; diabetes 2 years or less, no ASCVD; HbA1c 7.0 to 7.5 percent; BMI 18.5 to 30; metformin 1000 mg
S003072	14	completers	not stated	not stated	not stated	not stated	not stated	not stated	open_label	mixed	2011	age 20 to 80; HbA1c above 6.9 percent on sitagliptin 50 mg for 3 months or more

Trial data

What each trial contributes. Arm rows give the arm value with its standard error, or events over participants; contrast rows give the hazard ratio (from event counts) on the analysis scale (log) against the trial's first row. Flags mark converted, combined or approximated inputs.

Trial data entering this analysis
Trial	Arm	Treatment	Week	Data	Events / N	Flags	Source
AWARD-11	A1	DULA_SC_1p5MG_QW	52	arm, events	8 / 612		R0022783:Table 2
AWARD-11	A2	DULA_SC_3p0MG_QW	52	arm, events	2 / 616		R0022783:Table 2
AWARD-11	A3	DULA_SC_4p5MG_QW	52	arm, events	7 / 614		R0022783:Table 2
NCT02325960	A1	EXEN_SC_10UG_BID	16	arm, events	0 / 22		R0024438:Results
NCT02325960	A2	INS_GLARGINE	16	arm, events	0 / 23		R0024438:Results
DUAL™ I China	A1	IDEGLIRA_SC_TIT_QD	27	arm, events	29 / 361		R0012560:Table 2
DUAL™ I China	A2	INS_DEGLUDEC	27	arm, events	14 / 179		R0012560:Table 2
DUAL™ I China	A3	LIRA_SC_1p8MG_QD	27	arm, events	3 / 180		R0012560:Table 2
SURPASS-6	A1	TIRZ_SC_5MG_QW	56	arm, events	29 / 243		R0009666:Table 4
SURPASS-6	A2	TIRZ_SC_10MG_QW	56	arm, events	22 / 238		R0009666:Table 4
SURPASS-6	A3	TIRZ_SC_15MG_QW	56	arm, events	25 / 236		R0009666:Table 4
SURPASS-6	A4	INS_LISPRO	56	arm, events	340 / 711		R0009666:Table 4
PIONEER 4	A1	SEMA_PO_14MG_QD	57	arm, events	2 / 285		R0015836:Table 3
PIONEER 4	A2	LIRA_SC_1p8MG_QD	57	arm, events	7 / 284		R0015836:Table 3
PIONEER 4	A3	PLACEBO	57	arm, events	3 / 142		R0015836:Table 3
NCT04965506	A1	MAZD_SC_3MG_QW	24	arm, events	0 / 51		R0012443:Table 2
NCT04965506	A2	MAZD_SC_4p5MG_QW	24	arm, events	0 / 49		R0012443:Table 2
NCT04965506	A3	MAZD_SC_6MG_QW	24	arm, events	1 / 49		R0012443:Table 2
NCT04965506	A4	DULA_SC_1p5MG_QW	24	arm, events	0 / 50		R0012443:Table 2
NCT04965506	A5	PLACEBO	24	arm, events	1 / 51		R0012443:Table 2
COMBINE 2	A1	ICOSEMA_SC_TIT_QW	57	arm, events	12 / 342		R0005851:Table 4
COMBINE 2	A2	SEMA_SC_1p0MG_QW	57	arm, events	13 / 341		R0005851:Table 4
STEP HFpEF DM	A1	SEMA_SC_2p4MG_QW	57	arm, events	13 / 310		R0020223:Supplement Table S10
STEP HFpEF DM	A2	PLACEBO	57	arm, events	13 / 306		R0020223:Supplement Table S10
DUAL™IV	A1	IDEGLIRA_SC_TIT_QD	27	arm, events	120 / 289		R0015199:Table 2
DUAL™IV	A2	PLACEBO	27	arm, events	25 / 146		R0015199:Table 2
Lixilan-O-AP	A1	IGLARLIXI2_SC_TIT_QD	24.43	arm, events	23 / 351		R0013321:Table 3
Lixilan-O-AP	A2	INS_GLARGINE	24.43	arm, events	10 / 350		R0013321:Table 3
Lixilan-O-AP	A3	LIXI_SC_20UG_QD	24.43	arm, events	2 / 177		R0013321:Table 3
PB119	A1	VISEPE_SC_150UG_QW	24	arm, events	0 / 137		R0011471:Results
PB119	A2	PLACEBO	24	arm, events	0 / 136		R0011471:Results
PIONEER 10	A1	SEMA_PO_3MG_QD	57	arm, events	3 / 131		R0018421:Table 3
PIONEER 10	A2	SEMA_PO_7MG_QD	57	arm, events	3 / 132		R0018421:Table 3
PIONEER 10	A3	SEMA_PO_14MG_QD	57	arm, events	4 / 130		R0018421:Table 3
PIONEER 10	A4	DULA_SC_0p75MG_QW	57	arm, events	0 / 65		R0018421:Table 3
SUSTAIN™ 3	A1	SEMA_SC_1p0MG_QW	61	arm, events	33 / 406	count_from_percent	R0013158:Figure 5
SUSTAIN™ 3	A2	EXENER_SC_2MG_QW	61	arm, events	33 / 407	count_from_percent	R0013158:Figure 5
NCT00765817	A1	EXEN_SC_10UG_BID	30	arm, events	34 / 138		R0027069:Table 3
NCT00765817	A2	PLACEBO	30	arm, events	35 / 123		R0027069:Table 3
SUSTAIN 11	A1	SEMA_SC_1p0MG_QW	52	arm, events	169 / 874		R0022346:Table 2
SUSTAIN 11	A2	INS_ASPART	52	arm, events	379 / 874		R0022346:Table 2
SUSTAIN 7	A1	SEMA_SC_0p5MG_QW	45	arm, events	2 / 301	count_from_percent	registry:outcomes
SUSTAIN 7	A2	SEMA_SC_1p0MG_QW	45	arm, events	5 / 300	count_from_percent	registry:outcomes
SUSTAIN 7	A3	DULA_SC_0p75MG_QW	45	arm, events	3 / 300	count_from_percent	registry:outcomes
SUSTAIN 7	A4	DULA_SC_1p5MG_QW	45	arm, events	5 / 300	count_from_percent	registry:outcomes
NCT00637273	A1	EXENER_SC_2MG_QW	26	arm, events	2 / 170	count_from_percent	R0026900:Research design and methods
NCT00637273	A2	SITAGLIPTIN	26	arm, events	5 / 172	count_from_percent	R0026900:Research design and methods
NCT00637273	A3	PIOGLITAZONE	26	arm, events	1 / 172	count_from_percent	R0026900:Research design and methods
PIONEER 12	A1	SEMA_PO_3MG_QD	31	arm, events	5 / 361		R0019776:Table 3
PIONEER 12	A2	SEMA_PO_7MG_QD	31	arm, events	2 / 360		R0019776:Table 3
PIONEER 12	A3	SEMA_PO_14MG_QD	31	arm, events	2 / 361		R0019776:Table 3
PIONEER 12	A4	SITAGLIPTIN	31	arm, events	0 / 359		R0019776:Table 3
SUSTAIN 10	A1	SEMA_SC_1p0MG_QW	35	arm, events	5 / 290		registry:outcomes
SUSTAIN 10	A2	LIRA_SC_1p2MG_QD	35	arm, events	7 / 287		registry:outcomes
NCT00960661	A1	EXEN_SC_10UG_BID	30	arm, events	94 / 316	count_from_percent	R0016788:Results
NCT00960661	A2	INS_LISPRO	30	arm, events	128 / 321	count_from_percent	R0016788:Results
NCT02008682	A1	LIRA_SC_1p8MG_QD	26	arm, events	2 / 184		R0025836:Results
NCT02008682	A2	SITAGLIPTIN	26	arm, events	1 / 184		R0025836:Results
PREVAIL	A1	STANDARD_CARE	20	arm, events	1 / 33		R0010144:Table 3
PREVAIL	A2	INS_LISPRO	20	arm, events	8 / 35		R0010144:Table 3
PREVAIL	A3	EXEN_SC_10UG_BID	20	arm, events	5 / 35		R0010144:Table 3
NCT02229383	A1	EXENER_SC_2MG_QW	38	arm, events	13 / 233		R0014763:Table 3
NCT02229383	A2	PLACEBO	38	arm, events	13 / 231		R0014763:Table 3
NCT00434954	A1	EXEN_SC_10UG_BID	26	arm, events	3 / 248	count_from_percent	R0027127:Results
NCT00434954	A2	INS_PREMIX	26	arm, events	11 / 246	count_from_percent	R0027127:Results
GRADE	A1	INS_GLARGINE	386.13	arm, events	73 / 1,263		R0020895:Table 2
GRADE	A2	GLIMEPIRIDE	386.13	arm, events	106 / 1,254		R0020895:Table 2
NCT05759897	A1	PLACEBO	16	arm, events	0 / 39	printed_denominator	R0002101:Results
NCT05759897	A2	SAFIGL_PO_15MG_QD	16	arm, events	0 / 39	printed_denominator	R0002101:Results
NCT05759897	A3	SAFIGL_PO_30MG_QD	16	arm, events	0 / 39	printed_denominator	R0002101:Results
NCT05759897	A4	SAFIGL_PO_60MG_QD	16	arm, events	0 / 38	printed_denominator	R0002101:Results
NCT05759897	A5	SAFIGL_PO_90MG_QD	16	arm, events	0 / 39	printed_denominator	R0002101:Results
NCT01617434	A1	LIRA_SC_1p8MG_QD	27	arm, events	41 / 226		R0026247:Table 4
NCT01617434	A2	PLACEBO	27	arm, events	28 / 225		R0026247:Table 4
LIRA-Ramadan™	A1	LIRA_SC_1p8MG_QD	30	arm, events	5 / 172		R0025756:Results
LIRA-Ramadan™	A2	OTHER_ACTIVE_sulfonylurea	30	arm, events	16 / 171		R0025756:Results
AWARD-8	A1	DULA_SC_1p5MG_QW	24	arm, events	13 / 240		R0016038:Supplement Table S3
AWARD-8	A2	PLACEBO	24	arm, events	0 / 60		R0016038:Supplement Table S3
LIRA-SWITCH™	A1	LIRA_SC_1p8MG_QD	27	arm, events	0 / 203		R0025720:Table 1
LIRA-SWITCH™	A2	SITAGLIPTIN	27	arm, events	3 / 204		R0025720:Table 1
DURATION-NEO-2	A1	EXENER_SC_2MG_QW	28	arm, events	0 / 182		R0010641:Table 3
DURATION-NEO-2	A2	SITAGLIPTIN	28	arm, events	1 / 122		R0010641:Table 3
DURATION-NEO-2	A3	PLACEBO	28	arm, events	0 / 61		R0010641:Table 3
AWARD-6	A1	DULA_SC_1p5MG_QW	26	arm, events	0 / 299	count_from_percent	R0022281:Table 3
AWARD-6	A2	LIRA_SC_1p8MG_QD	26	arm, events	5 / 300	count_from_percent	R0022281:Table 3
LixiLan-O	A1	IGLARLIXI2_SC_TIT_QD	30.14	arm, events	38 / 469		R0015993:Table 1
LixiLan-O	A2	INS_GLARGINE	30.14	arm, events	32 / 467		R0015993:Table 1
LixiLan-O	A3	LIXI_SC_20UG_QD	30.14	arm, events	4 / 234		R0015993:Table 1
NCT06974825	A1	BGM050_SC_5MG_QW	20	arm, events	0 / 13		R0015161:Results
NCT06974825	A2	BGM050_SC_10MG_QW	20	arm, events	0 / 12		R0015161:Results
NCT06974825	A3	BGM050_SC_15MG_QW	20	arm, events	0 / 13		R0015161:Results
NCT06974825	A4	SEMA_SC_1p0MG_QW	20	arm, events	0 / 16		R0015161:Results
NCT06974825	A5	PLACEBO	20	arm, events	0 / 13		R0015161:Results
DUALTM IX	A1	IDEGLIRA_SC_TIT_QD	26	arm, events	27 / 210	count_from_percent	R0014323:Results
DUALTM IX	A2	INS_GLARGINE	26	arm, events	41 / 210	count_from_percent	R0014323:Results
SUSTAIN	A1	SEMA_SC_0p5MG_QW	35	arm, events	2 / 288		R0014802:Table 3
SUSTAIN	A2	SEMA_SC_1p0MG_QW	35	arm, events	6 / 290		R0014802:Table 3
SUSTAIN	A3	SITAGLIPTIN	35	arm, events	4 / 290		R0014802:Table 3
DUAL™ V	A1	IDEGLIRA_SC_TIT_QD	26	arm, events	79 / 278		registry:outcomes
DUAL™ V	A2	INS_GLARGINE	26	arm, events	137 / 279		registry:outcomes
NCT01003184	A1	EXENER_SC_2MG_QW	26	arm, events	5 / 111		R0027663:Table 2
NCT01003184	A2	INS_DETEMIR	26	arm, events	6 / 111		R0027663:Table 2
NCT03861039	A1	TIRZ_SC_5MG_QW	56	arm, events	1 / 148		registry:outcomes
NCT03861039	A2	TIRZ_SC_10MG_QW	56	arm, events	1 / 147		registry:outcomes
NCT03861039	A3	TIRZ_SC_15MG_QW	56	arm, events	3 / 148		registry:outcomes
SUSTAIN™	A1	SEMA_SC_0p5MG_QW	62	arm, events	3 / 239		R0025024:Table 2
SUSTAIN™	A2	SEMA_SC_1p0MG_QW	62	arm, events	6 / 241		R0025024:Table 2
SUSTAIN™	A3	OTHER_ACTIVE_additional_OAD	62	arm, events	2 / 121		R0025024:Table 2
NCT05486065	A1	SEMA_SC_2p0MG_QW	49	arm, events	1 / 61		R0005510:Results
NCT05486065	A2	SEMA_SC_8MG_QW	49	arm, events	0 / 62		R0005510:Results
NCT05486065	A3	SEMA_SC_16MG_QW	49	arm, events	0 / 62		R0005510:Results
NCT05486065	A4	PLACEBO	49	arm, events	1 / 60		R0005510:Results
DUAL™ II China	A1	IDEGLIRA_SC_TIT_QD	26	arm, events	34 / 302		R0012135:Supplement Table 6
DUAL™ II China	A2	INS_DEGLUDEC	26	arm, events	22 / 151		R0012135:Supplement Table 6
SURPASS-3	A1	TIRZ_SC_5MG_QW	56	arm, events	5 / 359		R0007214:Table 2
SURPASS-3	A2	TIRZ_SC_10MG_QW	56	arm, events	4 / 361		R0007214:Table 2
SURPASS-3	A3	TIRZ_SC_15MG_QW	56	arm, events	8 / 359		R0007214:Table 2
SURPASS-3	A4	INS_DEGLUDEC	56	arm, events	26 / 365		R0007214:Table 2
PIONEER 1	A1	SEMA_PO_3MG_QD	31	arm, events	5 / 175		registry:outcomes
PIONEER 1	A2	SEMA_PO_7MG_QD	31	arm, events	2 / 175		registry:outcomes
PIONEER 1	A3	SEMA_PO_14MG_QD	31	arm, events	1 / 175		registry:outcomes
PIONEER 1	A4	PLACEBO	31	arm, events	1 / 178		registry:outcomes
NCT01126580	A1	DULA_SC_1p5MG_QW	26	arm, events	0 / 269	count_from_percent	R0022281:Table 3
NCT01126580	A2	DULA_SC_0p75MG_QW	26	arm, events	1 / 270	count_from_percent	R0022281:Table 3
NCT01126580	A3	METFORMIN	26	arm, events	3 / 268	count_from_percent	R0022281:Table 3
PIONEER 11	A1	SEMA_PO_3MG_QD	31	arm, events	1 / 130		R0019663:Table 3
PIONEER 11	A2	SEMA_PO_7MG_QD	31	arm, events	1 / 130		R0019663:Table 3
PIONEER 11	A3	SEMA_PO_14MG_QD	31	arm, events	0 / 130		R0019663:Table 3
PIONEER 11	A4	PLACEBO	31	arm, events	0 / 131		R0019663:Table 3
SUSTAIN™ 5	A1	SEMA_SC_0p5MG_QW	35	arm, events	11 / 132		R0012671:Table 2
SUSTAIN™ 5	A2	SEMA_SC_1p0MG_QW	35	arm, events	14 / 132		R0012671:Table 2
SUSTAIN™ 5	A3	PLACEBO	35	arm, events	7 / 133		R0012671:Table 2
NCT02229227	A1	ALBI_SC_50MG_QW	26	arm, events	141 / 402		R0008089:Table 3
NCT02229227	A2	INS_LISPRO	26	arm, events	239 / 412		R0008089:Table 3
SURPASS-SWITCH	A1	TIRZ_SC_15MG_QW	44	arm, events	8 / 139	count_from_percent	R0008264:Results
SURPASS-SWITCH	A2	DULA_SC_4p5MG_QW	44	arm, events	4 / 143	count_from_percent	R0008264:Results
PIONEER 9	A1	SEMA_PO_3MG_QD	57	arm, events	0 / 49		registry:outcomes
PIONEER 9	A2	SEMA_PO_7MG_QD	57	arm, events	0 / 49		registry:outcomes
PIONEER 9	A3	SEMA_PO_14MG_QD	57	arm, events	0 / 48		registry:outcomes
PIONEER 9	A4	LIRA_SC_0p9MG_QD	57	arm, events	2 / 48		registry:outcomes
PIONEER 9	A5	PLACEBO	57	arm, events	0 / 49		registry:outcomes
DUAL™ I Japan	A1	IDEGLIRA_SC_TIT_QD	53	arm, events	106 / 275		R0014857:Table 2
DUAL™ I Japan	A2	INS_DEGLUDEC	53	arm, events	148 / 271		R0014857:Table 2
DUAL™ I Japan	A3	LIRA_SC_1p8MG_QD	53	arm, events	6 / 273		R0014857:Table 2
NCT00676338	A1	EXENER_SC_2MG_QW	26	arm, events	5 / 248		R0027761:Results
NCT00676338	A2	METFORMIN	26	arm, events	0 / 246		registry:outcomes
NCT00676338	A3	PIOGLITAZONE	26	arm, events	0 / 163		registry:outcomes
NCT00676338	A4	SITAGLIPTIN	26	arm, events	0 / 163		registry:outcomes
PIONEER 5	A1	SEMA_PO_14MG_QD	31	arm, events	9 / 163		registry:outcomes
PIONEER 5	A2	PLACEBO	31	arm, events	3 / 161		registry:outcomes
DUAL™ II Japan	A1	IDEGLIRA_SC_TIT_QD	27	arm, events	30 / 105	count_from_percent	R0015589:Results
DUAL™ II Japan	A2	INS_DEGLUDEC	27	arm, events	32 / 105	count_from_percent	R0015589:Results
NCT03550378	A1	COTA_SC_300UG_QD	8.43	arm, events	3 / 21		R0019218:Table 2
NCT03550378	A2	PLACEBO	8.43	arm, events	1 / 20		R0019218:Table 2
SUSTAIN™	A1	SEMA_SC_0p5MG_QW	35	arm, events	0 / 103		R0014736:Supplement Table S5
SUSTAIN™	A2	SEMA_SC_1p0MG_QW	35	arm, events	1 / 102		R0014736:Supplement Table S5
SUSTAIN™	A3	SITAGLIPTIN	35	arm, events	0 / 103		R0014736:Supplement Table S5
LEAD-5	A1	LIRA_SC_1p8MG_QD	26	arm, events	63 / 232	count_from_percent	R0027336:Results
LEAD-5	A2	PLACEBO	26	arm, events	19 / 115	count_from_percent	R0027336:Results
LEAD-5	A3	INS_GLARGINE	26	arm, events	67 / 234	count_from_percent	R0027336:Results
Lixilan-L-CN	A1	IGLARLIXI2_SC_TIT_QD	30	arm, events	25 / 212		R0014540:Supplement Table S4
Lixilan-L-CN	A2	INS_GLARGINE	30	arm, events	24 / 214		R0014540:Supplement Table S4
NCT05767255	A1	IDEGLIRA_SC_TIT_QD	4	arm, events	2 / 32	count_from_percent	R0007026:Results
NCT05767255	A2	OTHER_ACTIVE_basal_bolus_insulin	4	arm, events	10 / 33	count_from_percent	R0007026:Results
NCT04998032	A1	EFSUBA_SC_3MG_QW	24	arm, events	0 / 171		R0006975:Table 3
NCT04998032	A2	PLACEBO	24	arm, events	0 / 173		R0006975:Table 3
NCT02505334	A1	LIRA_SC_1p8MG_QD	26	arm, events	0 / 233		R0022075:Table 2
NCT02505334	A2	LIRA_SC_0p9MG_QD	26	arm, events	0 / 233		R0022075:Table 2
NCT01455441	A1	LIRA_SC_1p8MG_QD	16	arm, events	0 / 18		R0010221:Results
NCT01455441	A2	PLACEBO	16	arm, events	0 / 16		R0010221:Results
NCT03311724	A1	PLACEBO	16	arm, events	0 / 26		R0010282:Table 2
NCT03311724	A2	TIRZ_SC_12MG_QW	16	arm, events	0 / 29		R0010282:Table 2
NCT03311724	A3+A4	TIRZ_SC_15MG_QW	16	arm, events	0 / 56	arms_combined	R0010282:Table 2
PIONEER 3	A1	SEMA_PO_3MG_QD	83	arm, events	23 / 466		registry:outcomes
PIONEER 3	A2	SEMA_PO_7MG_QD	83	arm, events	24 / 466		registry:outcomes
PIONEER 3	A3	SEMA_PO_14MG_QD	83	arm, events	36 / 465		registry:outcomes
PIONEER 3	A4	SITAGLIPTIN	83	arm, events	39 / 467		registry:outcomes
NCT04466904	A2	MAZD_SC_4p5MG_QW	20	arm, events	0 / 8		R0009340:Table 2
NCT04466904	A4	DULA_SC_1p5MG_QW	20	arm, events	0 / 6	printed_denominator	R0009340:Table 2
NCT04466904	A5	PLACEBO	20	arm, events	0 / 12	printed_denominator	R0009340:Table 2
NCT00700817	A1	LIRA_SC_1p2MG_QD	52	arm, events	18 / 225	count_from_percent	R0024199:Abstract
NCT00700817	A2	LIRA_SC_1p8MG_QD	52	arm, events	18 / 221	count_from_percent	R0024199:Abstract
NCT00700817	A3	SITAGLIPTIN	52	arm, events	14 / 219	count_from_percent	R0024199:Abstract
PIONEER 8	A1	SEMA_PO_3MG_QD	57	arm, events	52 / 184		registry:outcomes
PIONEER 8	A2	SEMA_PO_7MG_QD	57	arm, events	47 / 182		registry:outcomes
PIONEER 8	A3	SEMA_PO_14MG_QD	57	arm, events	48 / 181		registry:outcomes
PIONEER 8	A4	PLACEBO	57	arm, events	54 / 184		registry:outcomes
NCT06256523	A1	BOFANG_SC_4MG_QW	29	arm, events	1 / 27	printed_denominator	R0002476:Results
NCT06256523	A2	PLACEBO	29	arm, events	0 / 9	printed_denominator	R0002476:Table
S002928	A1	PLACEBO	24	arm, events	0 / 41		R0007034:Table 4
S002928	A2	PEGLOX_SC_300UG_QW	24	arm, events	0 / 41		R0007034:Table 4
S002928	A3	PEGLOX_SC_400UG_QW	24	arm, events	0 / 41		R0007034:Table 4
S002946	A1	SEMA_SC_0p5MG_QW	26	arm, events	0 / 16		R0006360:Supplement Table S2
S002946	A2	DULA_SC_0p75MG_QW	26	arm, events	0 / 16		R0006360:Supplement Table S2
S002951	A1	PEGLOX_SC_0p3MG_QW	16	arm, events	0 / 104		R0007588:Table 3
S002951	A2	METFORMIN	16	arm, events	1 / 52		R0007588:Table 3
S002969	A1	LIRA_SC_1p8MG_QD	52.14	arm, events	0 / 13		R0010852:Supplementary Clinical Sequelae 1
S002969	A2	PLACEBO	52.14	arm, events	0 / 14		R0010852:Supplementary Clinical Sequelae 1
S002992	A1	IGLARLIXI2_SC_TIT_QD	26	arm, events	28 / 443		R0019745:Figure 1
S002992	A2	INS_PREMIX	26	arm, events	57 / 444		R0019745:Figure 1
S003050	A1	METFORMIN	12	arm, events	0 / 30		R0021314:Results
S003050	A2	DULA_SC_1p5MG_QW	12	arm, events	0 / 30		R0021314:Results
S003072	A1	VILDAGLIPTIN	14	arm, events	0 / 62		R0023470:Results
S003072	A2	LIRA_SC_0p9MG_QD	14	arm, events	0 / 60		R0023470:Results

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