parallel randomized trial

S002930

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

Type 2 diabetes (adults)S002930

Design

Randomized: 34
Start year
Treatment: 52 weeks, follow-up 52 weeks
Countries: Hungary (1 sites)
Sponsor: (non industry)
Eligibility: age over 45; T2DM at least 5 years; HbA1c 6.5 to 10 percent; BMI above 25; eGFR above 60

Conduct and analysis

Blinding: not reported
Sequence generation: not reported
Allocation concealment: not reported
Outcome adjudication: not reported
Primary estimand: not stated
Analysis population
Missing data

Arms

Arm	Treatment	Background	Randomized	Analyzed	Completed treatment
A1	Semaglutide 1.0 mg subcutaneous once weekly Semaglutide 1 mg weekly	metformin and statin; lifestyle: not reported	18
A2	Sitagliptin Sitagliptin 100 mg daily	metformin and statin; lifestyle: not reported	16

Baseline characteristics

As printed in the trial reports or registry, per arm or for the whole trial.

Characteristic	Statistic	Semaglutide 1.0 mg subcutaneous once weekly A1	Sitagliptin A2
age	mean (years)	57.9	59.4
age	sd (years)	10.6	11.9
bmi	mean (kg/m2)	37.96	31.26
bmi	sd (kg/m2)	10.64	2.75
diabetes duration	mean (years)	8.4	9.6
diabetes duration	sd (years)	3.6	3.2
egfr	median (mL/min/1.73 m2)	87	90
egfr	q1 (mL/min/1.73 m2)	74	73
egfr	q3 (mL/min/1.73 m2)	90	90
female	n	6	9
hba1c	mean (percent)	8.08	8.13
hba1c	sd (percent)	1.65	1.29
waist	mean (cm)	126.4	126.6
waist	sd (cm)	21.8	25.1

Results

6 adjudicated result lines, grouped by outcome. Open an outcome to see its values.

HbA1c change (5 lines; O01)

Week	Arm	Statistic	Estimate	SE or SD	Detail
26	A1	final	6.86 percent	1.12	not stated; other; R0004797:Table 2
26	A2	final	6.91 percent	0.95	not stated; other; R0004797:Table 3
52	A1	change	-1.5 percent		not stated; other; R0004797:Results
52	A1	final	6.57 percent	0.95	not stated; other; R0004797:Table 2
52	A2	final	7.11 percent	1.07	not stated; other; R0004797:Table 3

Percent body weight change (1 lines; O10)

Week	Arm	Statistic	Estimate	SE or SD	95% CI	Events / N	Detail
52	A1	percent change	-8.1 percent				not stated; other; R0004797:Results