parallel randomized trial

S002888

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

Overweight or obesity without diabetes (adults)S002888

Design

Randomized: 100
Start year: 2021
Treatment: 24 weeks, follow-up 24 weeks
Countries: China (1 sites)
Sponsor: (non industry)
Eligibility: BMI 28 or more; no diagnosed diabetes; no weight or insulin sensitivity drugs in prior 3 months

Conduct and analysis

Blinding: not reported
Sequence generation: not reported
Allocation concealment: not reported
Outcome adjudication: not reported
Primary estimand: not stated
Analysis population: randomized
Missing data: none

Arms

Arm	Treatment	Background	Randomized	Analyzed	Completed treatment
A1	liraglutide Liraglutide plus metformin	metformin 1500 mg daily; 500 kcal deficit diet and 150 min weekly exercise advice; lifestyle: standard	50	50
A2	Standard care or no added treatment Metformin alone (control)	metformin 1500 mg daily; 500 kcal deficit diet and 150 min weekly exercise advice; lifestyle: standard	50	50

Baseline characteristics

As printed in the trial reports or registry, per arm or for the whole trial.

Characteristic	Statistic	Liraglutide plus metformin A1	Standard care or no added treatment A2
age	mean (years)	34.80	35.78
age	sd (years)	9.60	12.89
bmi	mean (kg/m2)	36.34	34.67
bmi	sd (kg/m2)	3.57	4.29
female	n	30	27
hba1c	median (percent)	6.15	5.60
hba1c	q1 (percent)	5.68	5.20
hba1c	q3 (percent)	6.90	6.09
sbp	mean (mmHg)	141.38	139.26
sbp	sd (mmHg)	16.39	14.88
weight	mean (kg)	104.41	98.68
weight	sd (kg)	15.34	17.02

Results

4 adjudicated result lines, grouped by outcome. Open an outcome to see its values.

Percent body weight change (2 lines; O10)

Week	Arm	Statistic	Estimate	SE or SD	95% CI	Events / N	Detail
24	A1	percent change	-14.45 percent			50	not stated; randomized; R0003281:Results
24	A2	percent change	-11.32 percent			50	not stated; randomized; R0003281:Results

Discontinuation due to adverse events (2 lines; O26)

Week	Arm	Statistic	Estimate	SE or SD	95% CI	Events / N	Detail
	A1	events				0 / 50	not stated; randomized; R0003281:Methods
	A2	events				0 / 50	not stated; randomized; R0003281:Methods