Descriptive only
Death by suicide
Type 1 diabetes
longest follow-upRecorded harmsDoses of a drug pooledHazard ratio (from event counts)
3
Randomized trials
6
Treatments
208
Participants
0
Events
In plain language
No network meta-analysis was fitted here. The protocol requires at least two trials forming a connected network; this outcome has 3 trials. The trial data below are shown as reported.
Network of trials
Each circle is a treatment; each line joins treatments that were randomized against each other in at least one trial.
Comparability of the trials
Checked across designs (the set of treatments each trial compares) for eligibility, outcome definition and assessment, and the baseline factors above. Flags point to possible intransitivity; notes describe variation that is not tied to design.
- NoteOutcome assessment, time point: selected time points span 12 to 26 weeks
- NoteOutcome assessment, definition: mixed: not stated 2, severe hypoglycemia, serious adverse event row 1
- NoteRisk of bias, funding: mixed: mixed 1, not_reported 2
- NoteData handling, input conversions: printed_denominator 2
| Trial | time weeks | analysis set | definition | instrument | adjudicated | proportion method | intercurrent events (discontinuation) | intercurrent events (rescue) | blinding | funding | start year | Eligibility |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT01753362 | 26 | safety | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | not_reported | 2012 | type 1 diabetes 1 year or more on insulin; undetectable C-peptide; overweight or obese |
| NCT02962492 | 12 | safety | severe hypoglycemia, serious adverse event row | not stated | not stated | not stated | not stated | not stated | double_blind | not_reported | 2016 | established type 1 diabetes on insulin |
| ADJUST-T1D | 26 | safety | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | mixed | 2023 | age 18 to 65; type 1 diabetes on AID; BMI 30 or more |
Trial data
What each trial contributes. Arm rows give the arm value with its standard error, or events over participants; contrast rows give the hazard ratio (from event counts) on the analysis scale (log) against the trial's first row. Flags mark converted, combined or approximated inputs.
| Trial | Arm | Treatment | Week | Data | Value | SE | Events / N | Flags | Source |
|---|---|---|---|---|---|---|---|---|---|
| NCT01753362 | A1 | PLACEBO | 26 | arm, events | 0 / 26 | printed_denominator | registry:adverse_events | ||
| NCT01753362 | A2 | LIRA_SC | 26 | arm, events | 0 / 40 | printed_denominator | registry:adverse_events | ||
| NCT02962492 | A1 | PLACEBO | 12 | arm, events | 0 / 13 | registry:adverse_events | |||
| NCT02962492 | A2 | DAPAGLIFLOZIN | 12 | arm, events | 0 / 17 | registry:adverse_events | |||
| NCT02962492 | A3 | EXENER_SC | 12 | arm, events | 0 / 17 | registry:adverse_events | |||
| NCT02962492 | A4 | DAPAEXEN_SC | 12 | arm, events | 0 / 23 | registry:adverse_events | |||
| ADJUST-T1D | A1 | SEMA_SC | 26 | arm, events | 0 / 36 | registry:adverse_events | |||
| ADJUST-T1D | A2 | PLACEBO | 26 | arm, events | 0 / 36 | registry:adverse_events |
Rerun this analysis yourself
Remove treatments or trials and refit the frequentist and Bayesian models in your browser, with the same methods as the published analysis.