Descriptive only

Medullary thyroid carcinoma

Overweight or obesity without diabetes (adults)

longest follow-upRecorded harmsEach dose separatelyHazard ratio (from event counts)

Randomized trials

Treatments

1,515

Participants

Events

In plain language

No network meta-analysis was fitted here. The protocol requires at least two trials forming a connected network; this outcome has 5 trials. The trial data below are shown as reported.

Network of trials

Each circle is a treatment; each line joins treatments that were randomized against each other in at least one trial.

Node area shows participants; line width shows trials comparing two treatments directly. Blue: GLP-1 receptor agonist containing treatments; grey: comparators. Hover over or tab to a node or line for details.

Comparability of the trials

Checked across designs (the set of treatments each trial compares) for eligibility, outcome definition and assessment, and the baseline factors above. Flags point to possible intransitivity; notes describe variation that is not tied to design.

NoteOutcome assessment, time point: selected time points span 26 to 76 weeks
NoteOutcome assessment, definition: mixed: deaths 1, not stated 4
NoteData handling, input conversions: arms_combined 1

Comparability items per trial
Trial	time weeks	analysis set	definition	instrument	adjudicated	proportion method	intercurrent events (discontinuation)	intercurrent events (rescue)	blinding	funding	start year	Eligibility
NCT02075281	26	safety	not stated	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2014	age 18 to 64 years; BMI 30 to 42, or 27 to 30 with comorbidity; FPG below 7 mmol/L; HbA1c 6.5 percent or less; no diabetes
NCT04904913	36	safety	not stated	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2021	Chinese adults 18 to 75; BMI 28 or more, or 24 or more with comorbidity or hyperphagia; no diabetes, HbA1c below 6.5
NCT05623839	27	safety	not stated	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2022	age 18 to 70; BMI 27 to 50; HbA1c below 6.5 percent; no diabetes
SURMOUNT-3	76	safety	not stated	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2021	age 18 or older; BMI 30 or more, or 27 or more with comorbidity; no diabetes; at least 5 percent loss in lead in
NCT01557166	34	safety	deaths	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2012	age 18 to 64; BMI 30 or more; AHI 15 or more; no diabetes; unable or unwilling to use CPAP

Trial data

What each trial contributes. Arm rows give the arm value with its standard error, or events over participants; contrast rows give the hazard ratio (from event counts) on the analysis scale (log) against the trial's first row. Flags mark converted, combined or approximated inputs.

Trial data entering this analysis
Trial	Arm	Treatment	Week	Data	Events / N	Flags	Source
NCT02075281	A1	PLACEBO	26	arm, events	0 / 60		R0011218:Results
NCT02075281	A2	EFPE_SC_4MG_QW	26	arm, events	0 / 59		R0011218:Results
NCT02075281	A3	EFPE_SC_6MG_QW	26	arm, events	0 / 59		R0011218:Results
NCT02075281	A4	EFPE_SC_6MG_Q2W	26	arm, events	0 / 59		R0011218:Results
NCT02075281	A5	EFPE_SC_8MG_Q2W	26	arm, events	0 / 60		R0011218:Results
NCT04904913	A1	MAZD_SC_3MG_QW	36	arm, events	0 / 62		R0016107:Results
NCT04904913	A2	MAZD_SC_4p5MG_QW	36	arm, events	0 / 63		R0016107:Results
NCT04904913	A3	MAZD_SC_6MG_QW	36	arm, events	0 / 61		R0016107:Results
NCT04904913	A4	PLACEBO	36	arm, events	0 / 62		R0016107:Results
NCT05623839	A1	PLACEBO	27	arm, events	0 / 8		R0013210:Supplement Table S2
NCT05623839	A2+A3	MAZD_SC_16MG_QW	27	arm, events	0 / 24	arms_combined	R0013210:Supplement Table S2
SURMOUNT-3	A1	TIRZ_SC_MTD_QW	76	arm, events	0 / 287		R0007405:Results
SURMOUNT-3	A2	PLACEBO	76	arm, events	0 / 292		R0007405:Results
NCT01557166	A1	LIRA_SC_3p0MG_QD	34	arm, events	0 / 180		R0026203:Results
NCT01557166	A2	PLACEBO	34	arm, events	0 / 179		R0026203:Results

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