Descriptive only
Acute kidney injury
Overweight or obesity without diabetes (adults)
longest follow-upRecorded harmsDoses of a drug pooledHazard ratio (from event counts)
7
Randomized trials
9
Treatments
4,181
Participants
14
Events
In plain language
No network meta-analysis was fitted here. The protocol requires at least two trials forming a connected network; this outcome has 7 trials. The trial data below are shown as reported.
Network of trials
Each circle is a treatment; each line joins treatments that were randomized against each other in at least one trial.
Comparability of the trials
Checked across designs (the set of treatments each trial compares) for eligibility, outcome definition and assessment, and the baseline factors above. Flags point to possible intransitivity; notes describe variation that is not tied to design.
- NoteOutcome assessment, time point: selected time points span 24 to 104 weeks
- NoteOutcome assessment, intercurrent events (discontinuation): mixed: not stated 6, while_on_treatment 1
- NoteOutcome assessment, intercurrent events (rescue): mixed: not stated 6, treatment_policy 1
- NoteRisk of bias, blinding: mixed: double_blind 6, open_label 1
- NoteData handling, input conversions: arms_combined 6, nonserious_only 6
| Trial | instrument | time weeks | analysis set | definition | adjudicated | proportion method | intercurrent events (discontinuation) | intercurrent events (rescue) | blinding | funding | start year | Eligibility |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT05579977 | not stated | 28 | safety | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2022 | age 18 to 75; T2D cohort on metformin, HbA1c 7.0 to 10.0, BMI 23 or more; obesity cohort BMI 30 or more without diabetes |
| STEP 1 | not stated | 75 | safety | not stated | not stated | not stated | while_on_treatment | treatment_policy | double_blind | industry | 2018 | adults; BMI 30 or more, or 27 or more with a weight related condition; no diabetes; HbA1c below 6.5 percent |
| NCT05616013 | not stated | 104 | safety | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2022 | adults 18 to 80; BMI 30 or more, or 27 or more with comorbidity; no diabetes (HbA1c below 6.5 percent); weight below 150 kg |
| ACCESS | not stated | 36 | safety | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2024 | age 18 to 79; BMI 30 or more, or 27 or more with comorbidity; HbA1c below 6.5 percent; weight above 80 kg; no diabetes |
| STEP 3 | not stated | 75 | safety | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2018 | BMI 30 or more, or 27 with comorbidity; no type 2 diabetes |
| Dapalost | not stated | 24 | safety | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2014 | age 18 to 70; BMI 30 to 45 kg/m2; no diabetes |
| NCT05623839 | not stated | 27 | safety | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2022 | age 18 to 70; BMI 27 to 50; HbA1c below 6.5 percent; no diabetes |
Trial data
What each trial contributes. Arm rows give the arm value with its standard error, or events over participants; contrast rows give the hazard ratio (from event counts) on the analysis scale (log) against the trial's first row. Flags mark converted, combined or approximated inputs.
| Trial | Arm | Treatment | Week | Data | Value | SE | Events / N | Flags | Source |
|---|---|---|---|---|---|---|---|---|---|
| STEP 1 | A1 | SEMA_SC | 75 | arm, events | 3 / 1,306 | R0023399:Table 3 | |||
| STEP 1 | A2 | PLACEBO | 75 | arm, events | 2 / 655 | R0023399:Table 3 | |||
| NCT05579977 | A1+A8 | PLACEBO | 28 | arm, events | 0 / 139 | nonserious_only;arms_combined | registry:adverse_events | ||
| NCT05579977 | A10+A11+A12+A13+A2+A3+A4+A5+A6+A9 | LOTI_PO | 28 | arm, events | 3 / 690 | nonserious_only;arms_combined | registry:adverse_events | ||
| NCT05579977 | A7 | SEMA_PO | 28 | arm, events | 0 / 73 | nonserious_only | registry:adverse_events | ||
| NCT05616013 | A3 | OTHER_ACTIVE_bimagrumab | 104 | arm, events | 1 / 57 | nonserious_only | registry:adverse_events | ||
| NCT05616013 | A4+A5 | SEMA_SC | 104 | arm, events | 2 / 113 | nonserious_only;arms_combined | registry:adverse_events | ||
| NCT05616013 | A6+A7+A8+A9 | BIMASEMA_SC | 104 | arm, events | 0 / 225 | nonserious_only;arms_combined | registry:adverse_events | ||
| ACCESS | A1+A2+A3 | ALENIG_PO | 36 | arm, events | 3 / 174 | arms_combined | R0000892:Extended Data Table 1 | ||
| ACCESS | A4 | PLACEBO | 36 | arm, events | 0 / 56 | R0000892:Extended Data Table 1 | |||
| STEP 3 | A1 | SEMA_SC | 75 | arm, events | 0 / 407 | R0020858:Table 2 | |||
| STEP 3 | A2 | PLACEBO | 75 | arm, events | 0 / 204 | R0020858:Table 2 | |||
| Dapalost | A1 | EXENER_SC | 24 | arm, events | 0 / 25 | R0025627:Table 3 | |||
| Dapalost | A2 | PLACEBO | 24 | arm, events | 0 / 25 | R0025627:Table 3 | |||
| NCT05623839 | A1 | PLACEBO | 27 | arm, events | 0 / 8 | R0013210:Supplement Table S2 | |||
| NCT05623839 | A2+A3 | MAZD_SC | 27 | arm, events | 0 / 24 | arms_combined | R0013210:Supplement Table S2 |
Rerun this analysis yourself
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