Descriptive only
Death by suicide
Type 2 diabetes (adults)
longest follow-upRecorded harmsDoses of a drug pooledHazard ratio (from event counts)
43
Randomized trials
26
Treatments
14,225
Participants
1
Events
In plain language
No network meta-analysis was fitted here. The protocol requires at least two trials forming a connected network; this outcome has 43 trials. The trial data below are shown as reported.
Network of trials
Each circle is a treatment; each line joins treatments that were randomized against each other in at least one trial.
Comparability of the trials
Checked across designs (the set of treatments each trial compares) for eligibility, outcome definition and assessment, and the baseline factors above. Flags point to possible intransitivity; notes describe variation that is not tied to design.
- FlagEligibility, bmi entry range: a design requires bmi 50 or more while another admits only 35 or less
- NoteOutcome assessment, time point: selected time points span 5 to 78.21 weeks
- NoteOutcome assessment, analysis set: mixed: completers 1, full_analysis 2, modified_itt 3, other 4, randomized 4, safety 29
- NoteOutcome assessment, definition: mixed: ADA 2018 level 2 (below 3.0 mmol/L); level 3 row zero in all arms 1, C-SSRS post baseline category 1, Grade 3, needing third party assistance 1, Hypoglycemia adverse event of special interest 1, hypoglycemia requiring medical assistance 1, minor: symptoms with glucose below 3 mmol/L, self treated or resolved 1, minor: symptoms with glucose below 3.0 mmol/L, self treated 1, not stated 21, plasma glucose 54 mg/dL or lower 1, Severe (ADA) or glucose confirmed below 3.1 mmol/L with symptoms 1, severe hypoglycemia 1, severe hypoglycemia needing assistance of another person 1, Severe hypoglycemia needing assistance with glucose below 36 mg/dL or prompt recovery 1, Severe hypoglycemia requiring assistance of another person 1, severe hypoglycemia requiring third party assistance 1, severe symptomatic hypoglycemia needing assistance 1, severe symptomatic hypoglycemia needing assistance of another person, glucose below 2.0 mmol/L or prompt recovery 1, severe, requiring assistance of another person 2, symptomatic hypoglycemia confirmed below 3.3 mmol/L 1, symptomatic mild hypoglycemia, no glucose threshold printed 1, TEAE leading to death 1, Zero implied by no hypoglycemia episodes of any kind 1
- NoteOutcome assessment, adjudicated: mixed: not stated 42, yes 1
- NoteOutcome assessment, proportion method: mixed: not stated 41, observed 2
- NoteOutcome assessment, intercurrent events (discontinuation): mixed: not stated 42, while_on_treatment 1
- NoteOutcome assessment, intercurrent events (rescue): mixed: not stated 42, treatment_policy 1
- NoteRisk of bias, blinding: mixed: double_blind 25, open_label 16, single_blind 2
- NoteRisk of bias, funding: mixed: industry 36, mixed 4, non_industry 3
- NoteData handling, input conversions: arms_combined 15, printed_denominator 7
| Trial | time weeks | analysis set | definition | instrument | adjudicated | proportion method | intercurrent events (discontinuation) | intercurrent events (rescue) | blinding | funding | start year | Eligibility |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT03131687 | 30 | safety | severe hypoglycemia needing assistance of another person | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2017 | age 18 to 75; T2D at least 6 months; HbA1c 7.0 to 10.5%; BMI 23 to 50; diet and exercise or metformin |
| NCT02325960 | 16 | safety | not stated | not stated | not stated | not stated | not stated | not stated | open_label | mixed | 2015 | age 18 to 70; BMI 24 or more; HbA1c 7.0 to 10.0 percent; metformin 1.5 g/day or more |
| PIONEER 4 | 57 | safety | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2016 | Age 18 or older; T2D on metformin with or without SGLT2i; HbA1c 7.0 to 9.5 percent; eGFR 60 or more |
| MAGNA VICTORIA | 26 | safety | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | mixed | 2015 | South Asian descent; age 18 to 74; BMI 23 or more; HbA1c 6.5 to 11.0 percent |
| Lixilan-O-AP | 24.43 | safety | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2019 | adults with T2D on metformin with or without a second OAD; HbA1c 7.5 to 11 percent, or 7 to 10 percent with a non SGLT2i second OAD |
| PIONEER 10 | 57 | safety | not stated | not stated | yes | not stated | while_on_treatment | treatment_policy | single_blind | industry | 2017 | Japanese adults 20 or older; T2D; HbA1c 7.0 to 10.5 percent on one oral glucose lowering drug |
| NCT00765817 | 30 | full_analysis | minor: symptoms with glucose below 3 mmol/L, self treated or resolved | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2008 | adults 18 or older; insulin glargine 20 U/d or more alone or with metformin or pioglitazone; HbA1c 7.1 to 10.5 percent; BMI 45 or less |
| NCT05579977 | 28 | safety | C-SSRS post baseline category | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2022 | age 18 to 75; T2D cohort on metformin, HbA1c 7.0 to 10.0, BMI 23 or more; obesity cohort BMI 30 or more without diabetes |
| GETGOAL-L-ASIA | 24 | safety | severe symptomatic hypoglycemia needing assistance | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2009 | age 25 to 81; type 2 diabetes at least 1 year; stable basal insulin at least 10 U/day with or without sulfonylurea; HbA1c 7 to 10 percent |
| NCT03951753 | 32 | safety | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2019 | age 20 to 74; BMI 25 to 45; metformin with or without one other oral agent |
| NCT00960661 | 30 | other | minor: symptoms with glucose below 3.0 mmol/L, self treated | not stated | not stated | observed | not stated | not stated | open_label | industry | 2009 | age 18 or older; T2D on insulin glargine and metformin with or without sulfonylurea; HbA1c 7.0 to 10.0; BMI 25.0 (23.0 in South Korea) to 45.0; HbA1c above 7.0 after optimization |
| NCT00577824 | 24 | full_analysis | Severe hypoglycemia requiring assistance of another person | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2008 | age 20 to 75; HbA1c 7.0 to 10.0 percent JDS; weight 50 kg or more; sulfonylurea based oral therapy |
| GetGoal-Duo1 | 24 | safety | symptomatic hypoglycemia confirmed below 3.3 mmol/L | not stated | not stated | observed | not stated | not stated | double_blind | industry | 2009 | T2D on metformin 1.5 g or more with or without SU, glinide or TZD, HbA1c 7 to 10, BMI over 20; HbA1c 7 to 9 after run in |
| NCT01558271 | 52 | safety | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2012 | Japanese; age 20 or more; BMI 18.5 to 35; HbA1c 7.0 to 10.0 percent; OAM naive or OAM stopped |
| AWARD-CHN1 | 26 | safety | severe, requiring assistance of another person | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2012 | age 18 or older; BMI 19 to 35 kg/m2; HbA1c 7.0 to 10.5 percent OAM naive or 6.5 to 10.0 percent on OAM monotherapy |
| AWARD-8 | 24 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2013 | age 18 or older; BMI up to 45; HbA1c 7.5 to 9.5 percent on sulfonylurea at least half maximal dose |
| LixiLan-G | 26 | safety | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2016 | T2D 1 year or more; HbA1c 7 to 9 percent; BMI over 20 to 40; maximum tolerated GLP-1 RA plus metformin |
| SUSTAIN | 35 | safety | Severe (ADA) or glucose confirmed below 3.1 mmol/L with symptoms | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2017 | Adults 18 or older, HbA1c 7.0 to 10.5 percent on metformin monotherapy, eGFR 60 or more |
| AWARD-CHN2 | 52 | safety | severe, requiring assistance of another person | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2012 | age 18 or older; BMI 19 to 35 kg/m2; HbA1c 7.0 to 11.0 percent on metformin and/or sulfonylurea |
| NCT02212067 | 17 | randomized | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2014 | age 18 to 64; HbA1c 6.5 to 9.0 percent; BMI 20 to 35; diet and exercise or metformin |
| NCT00744926 | 24 | safety | severe hypoglycemia | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2008 | age 18 to 80; drug naive; HbA1c 6.5 to 10 percent; BMI 25 to 45 |
| ELEGANT | 26 | randomized | Grade 3, needing third party assistance | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2012 | age 18 to 75; BMI 25 or more; HbA1c 6.5 to 8.5 percent; insulin 3 to 16 months with 4 percent weight gain |
| PIONEER 11 | 31 | safety | ADA 2018 level 2 (below 3.0 mmol/L); level 3 row zero in all arms | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2019 | age 18 or older; HbA1c 7.0 to 10.0 percent at screening, 7.0 to 9.5 at randomization; no glucose lowering drugs; eGFR 60 or more |
| SUSTAIN™ 5 | 35 | safety | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2014 | age 18 or older (20 in Japan); HbA1c 7.0 to 10.0 percent; stable basal insulin with or without metformin; eGFR 30 or more |
| DUAL™ I Japan | 53 | safety | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2015 | Japanese adults 20 or older; HbA1c 7.0 to 11.0 percent; BMI at least 20; insulin naive on one oral drug |
| NCT05086445 | 14 | safety | Hypoglycemia adverse event of special interest | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2021 | Japanese; age 20 to 70; BMI 20 to 35; HbA1c 7.0 to 10.0 diet only or 6.5 to 9.0 on one OAM, withdrawn 28 days |
| LIXILAN JP-O1 | 52.43 | safety | TEAE leading to death | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2016 | insulin naive Japanese adults; HbA1c 7.5 to 10%; FPG 13.8 mmol/L or less; one or two OADs |
| NCT02887625 | 78.21 | other | severe hypoglycemia requiring third party assistance | not stated | not stated | not stated | not stated | not stated | open_label | mixed | 2015 | age 18 to 75; HbA1c above 7.5 percent on near maximal metformin plus sulfonylurea |
| SUSTAIN™ | 35 | safety | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2014 | Japanese; age 20 or older; HbA1c 6.5 to 9.5 percent on one OAD or 7.0 to 10.5 percent on diet and exercise |
| NCT02288273 | 14 | modified_itt | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2014 | age 18 to 75; T2D on metformin 1500 mg or more; HbA1c 7.0 to 10.0 percent; BMI 45 or less |
| Lixilan-L-CN | 30.43 | safety | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2019 | Chinese adults; HbA1c 7.0 to 10.5 percent; basal insulin 10 to 25 U/day with up to 2 oral drugs; FPG at most 8.9 mmol/L |
| GETGOAL-M | 24 | safety | severe symptomatic hypoglycemia needing assistance of another person, glucose below 2.0 mmol/L or prompt recovery | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2008 | type 2 diabetes on metformin 1.5 g/day or more for 3 months; HbA1c 7 to 10 percent; FPG 13.9 mmol/L or less |
| NCT01455441 | 16 | completers | Zero implied by no hypoglycemia episodes of any kind | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2011 | age over 18; HbA1c 7 to 11 percent; BMI over 25; diet or metformin; sedentary |
| NCT03311724 | 16 | modified_itt | plasma glucose 54 mg/dL or lower | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2017 | age 18 to 75; T2D at least 6 months; HbA1c 7.0 to 10.5%; BMI 23 to 45; diet or stable metformin |
| NCT04466904 | 20 | safety | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2020 | age 18 to 75; T2D on diet and exercise or stable metformin; HbA1c 7.5 to 11.0 percent; BMI 20 to 35 |
| NCT00700817 | 52 | other | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | 2008 | age 18 to 80; HbA1c 7.5 to 10%; BMI 45 or less; metformin 1500 mg/day or more for 3 months |
| S002858 | 24 | randomized | not stated | not stated | not stated | not stated | not stated | not stated | double_blind | industry | T2D age over 35; clinical CKD; eGFR above 30 mL/min; stable ACE inhibitor or ARB | |
| S002885 | 12 | other | symptomatic mild hypoglycemia, no glucose threshold printed | not stated | not stated | not stated | not stated | not stated | open_label | non_industry | 2019 | age 20 to 75; HbA1c 7.0 or more on metformin and glimepiride; eGFR 30 or more |
| S002928 | 24 | safety | not stated | not stated | not stated | not stated | not stated | not stated | single_blind | non_industry | 2022 | age 18 to 65; BMI 50 or more; type 2 diabetes |
| S002984 | 24 | randomized | not stated | not stated | not stated | not stated | not stated | not stated | open_label | mixed | 2020 | T2D age 45 or older; HbA1c 7.0 to 11.0 percent; metformin at least 3 months |
| S002992 | 26.43 | safety | not stated | not stated | not stated | not stated | not stated | not stated | open_label | industry | adults 18 or older; HbA1c 7.5 to 10 percent; BMI 20 to less than 40; basal insulin 20 to 50 U plus metformin with or without SGLT2i | |
| S003047 | 6.57 | safety | Severe hypoglycemia needing assistance with glucose below 36 mg/dL or prompt recovery | not stated | not stated | not stated | not stated | not stated | double_blind | industry | 2006 | age 20 to 75; HbA1c 7.0 to 10.0 percent; BMI 35 or less; sulfonylurea with or without metformin |
| S003079 | 5 | safety | hypoglycemia requiring medical assistance | not stated | not stated | not stated | not stated | not stated | open_label | non_industry | 2010 | age 18 to 80, HbA1c 7.5 to 12 percent, BMI 21 to 35, T2D at least 6 months |
Trial data
What each trial contributes. Arm rows give the arm value with its standard error, or events over participants; contrast rows give the hazard ratio (from event counts) on the analysis scale (log) against the trial's first row. Flags mark converted, combined or approximated inputs.
| Trial | Arm | Treatment | Week | Data | Value | SE | Events / N | Flags | Source |
|---|---|---|---|---|---|---|---|---|---|
| NCT03131687 | A1 | PLACEBO | 30 | arm, events | 0 / 51 | R0016215:Table 3 | |||
| NCT03131687 | A2+A3+A4+A5 | TIRZ_SC | 30 | arm, events | 0 / 213 | arms_combined | R0016215:Table 3 | ||
| NCT03131687 | A6 | DULA_SC | 30 | arm, events | 0 / 54 | R0016215:Table 3 | |||
| NCT02325960 | A1 | EXEN_SC | 16 | arm, events | 0 / 22 | R0024438:Results | |||
| NCT02325960 | A2 | INS_GLARGINE | 16 | arm, events | 0 / 23 | R0024438:Results | |||
| PIONEER 4 | A1 | SEMA_PO | 57 | arm, events | 0 / 285 | R0015836:Supplement Table S6 | |||
| PIONEER 4 | A2 | LIRA_SC | 57 | arm, events | 0 / 284 | R0015836:Supplement Table S6 | |||
| PIONEER 4 | A3 | PLACEBO | 57 | arm, events | 0 / 142 | R0015836:Supplement Table S6 | |||
| MAGNA VICTORIA | A1 | LIRA_SC | 26 | arm, events | 0 / 22 | R0020542:Results | |||
| MAGNA VICTORIA | A2 | PLACEBO | 26 | arm, events | 0 / 25 | R0020542:Results | |||
| Lixilan-O-AP | A1 | IGLARLIXI_SC | 24.43 | arm, events | 0 / 351 | R0013321:Results | |||
| Lixilan-O-AP | A2 | INS_GLARGINE | 24.43 | arm, events | 0 / 350 | R0013321:Results | |||
| Lixilan-O-AP | A3 | LIXI_SC | 24.43 | arm, events | 0 / 177 | R0013321:Results | |||
| PIONEER 10 | A1+A2+A3 | SEMA_PO | 57 | arm, events | 0 / 393 | arms_combined | R0018421:Table 2 | ||
| PIONEER 10 | A4 | DULA_SC | 57 | arm, events | 0 / 65 | R0018421:Table 2 | |||
| NCT00765817 | A1 | EXEN_SC | 30 | arm, events | 0 / 138 | R0027069:Table 3 | |||
| NCT00765817 | A2 | PLACEBO | 30 | arm, events | 0 / 123 | R0027069:Results | |||
| NCT05579977 | A10+A11+A12+A13+A9 | LOTI_PO | 28 | arm, events | 0 / 325 | arms_combined | registry:outcomes | ||
| NCT05579977 | A8 | PLACEBO | 28 | arm, events | 0 / 64 | registry:outcomes | |||
| GETGOAL-L-ASIA | A1 | LIXI_SC | 24 | arm, events | 0 / 154 | R0022626:Results | |||
| GETGOAL-L-ASIA | A2 | PLACEBO | 24 | arm, events | 1 / 157 | R0022626:Results | |||
| NCT03951753 | A1 | TIRZ_SC | 32 | arm, events | 0 / 45 | registry:adverse_events | |||
| NCT03951753 | A2 | SEMA_SC | 32 | arm, events | 0 / 44 | registry:adverse_events | |||
| NCT03951753 | A3 | PLACEBO | 32 | arm, events | 0 / 28 | registry:adverse_events | |||
| NCT00960661 | A1 | EXEN_SC | 30 | arm, events | 0 / 316 | R0016788:Results | |||
| NCT00960661 | A2 | INS_LISPRO | 30 | arm, events | 0 / 321 | R0016788:Figure 1 | |||
| NCT00577824 | A1 | PLACEBO | 24 | arm, events | 0 / 36 | R0018881:Results | |||
| NCT00577824 | A2+A3 | EXEN_SC | 24 | arm, events | 0 / 145 | arms_combined | R0018881:Results | ||
| GetGoal-Duo1 | A1 | PLACEBO | 24 | arm, events | 0 / 223 | R0026107:Results | |||
| GetGoal-Duo1 | A2 | LIXI_SC | 24 | arm, events | 0 / 223 | R0026107:Results | |||
| NCT01558271 | A1 | DULA_SC | 52 | arm, events | 0 / 281 | R0011754:Table 2 | |||
| NCT01558271 | A2 | LIRA_SC | 52 | arm, events | 0 / 141 | R0011754:Table 2 | |||
| AWARD-CHN1 | A1 | DULA_SC | 26 | arm, events | 0 / 244 | R0014229:Table 2 | |||
| AWARD-CHN1 | A3 | GLIMEPIRIDE | 26 | arm, events | 0 / 245 | R0014229:Table 2 | |||
| AWARD-8 | A1 | DULA_SC | 24 | arm, events | 0 / 240 | R0016038:Results | |||
| AWARD-8 | A2 | PLACEBO | 24 | arm, events | 0 / 60 | R0016038:Results | |||
| LixiLan-G | A1 | IGLARLIXI_SC | 26 | arm, events | 0 / 257 | registry:adverse_events | |||
| LixiLan-G | A2 | GLP1RE_SC | 26 | arm, events | 0 / 257 | registry:adverse_events | |||
| SUSTAIN | A1 | SEMA_SC | 35 | arm, events | 0 / 288 | R0014802:Results | |||
| SUSTAIN | A3 | SITAGLIPTIN | 35 | arm, events | 0 / 290 | R0014802:Table 3 | |||
| AWARD-CHN2 | A2 | DULA_SC | 52 | arm, events | 0 / 257 | R0023722:Table 2 | |||
| AWARD-CHN2 | A3 | INS_GLARGINE | 52 | arm, events | 0 / 259 | R0023722:Table 2 | |||
| NCT02212067 | A1 | SEMA_SC | 17 | arm, events | 0 / 37 | R0021892:Supplement Table 2 | |||
| NCT02212067 | A2 | PLACEBO | 17 | arm, events | 0 / 38 | R0021892:Supplement Table 2 | |||
| NCT00744926 | A1 | PLACEBO | 24 | arm, events | 0 / 123 | printed_denominator | R0025346:Results | ||
| NCT00744926 | A2+A3 | TASP_SC | 24 | arm, events | 0 / 245 | printed_denominator;arms_combined | R0025346:Results | ||
| ELEGANT | A1 | LIRA_SC | 26 | arm, events | 0 / 26 | R0025175:Results | |||
| ELEGANT | A2 | STANDARD_CARE | 26 | arm, events | 0 / 24 | R0025175:Results | |||
| PIONEER 11 | A1+A2+A3 | SEMA_PO | 31 | arm, events | 0 / 390 | arms_combined | R0019663:Table 3 | ||
| PIONEER 11 | A4 | PLACEBO | 31 | arm, events | 0 / 131 | R0019663:Table 3 | |||
| SUSTAIN™ 5 | A1+A2 | SEMA_SC | 35 | arm, events | 0 / 264 | arms_combined | R0012671:Table 2 | ||
| SUSTAIN™ 5 | A3 | PLACEBO | 35 | arm, events | 0 / 133 | R0012671:Table 2 | |||
| DUAL™ I Japan | A1 | IDEGLIRA_SC | 53 | arm, events | 0 / 275 | registry:adverse_events | |||
| DUAL™ I Japan | A2 | INS_DEGLUDEC | 53 | arm, events | 0 / 271 | registry:adverse_events | |||
| DUAL™ I Japan | A3 | LIRA_SC | 53 | arm, events | 0 / 273 | registry:adverse_events | |||
| NCT05086445 | A1 | PLACEBO | 14 | arm, events | 0 / 11 | R0003844:Table 2 | |||
| NCT05086445 | A2+A3+A4 | ORFO_PO | 14 | arm, events | 0 / 49 | arms_combined | R0003844:Table 2 | ||
| LIXILAN JP-O1 | A1 | IGLARLIXI_SC | 52.43 | arm, events | 0 / 161 | R0015751:Table 3 | |||
| LIXILAN JP-O1 | A2 | LIXI_SC | 52.43 | arm, events | 0 / 160 | R0015751:Results | |||
| NCT02887625 | A1 | EXENER_SC | 78.21 | arm, events | 0 / 129 | R0026120:Supplementary Table 1 | |||
| NCT02887625 | A2 | OTHER_ACTIVE_basal_bolus_insulin | 78.21 | arm, events | 0 / 122 | R0026120:Supplementary Table 1 | |||
| SUSTAIN™ | A1+A2 | SEMA_SC | 35 | arm, events | 0 / 205 | arms_combined | R0014736:Table 2 | ||
| SUSTAIN™ | A3 | SITAGLIPTIN | 35 | arm, events | 0 / 103 | R0014736:Table 2 | |||
| NCT02288273 | A1 | EXENER_SC | 14 | arm, events | 0 / 61 | R0025397:Results | |||
| NCT02288273 | A2 | PLACEBO | 14 | arm, events | 0 / 56 | R0025397:Results | |||
| Lixilan-L-CN | A1 | IGLARLIXI_SC | 30.43 | arm, events | 0 / 212 | R0014540:Table 3 | |||
| Lixilan-L-CN | A2 | INS_GLARGINE | 30.43 | arm, events | 0 / 214 | R0014540:Table 3 | |||
| GETGOAL-M | A1+A2 | LIXI_SC | 24 | arm, events | 0 / 510 | arms_combined | R0025872:Table 2 | ||
| GETGOAL-M | A3 | PLACEBO | 24 | arm, events | 0 / 170 | printed_denominator | R0025872:Table 2 | ||
| NCT01455441 | A1 | LIRA_SC | 16 | arm, events | 0 / 18 | R0010221:Results | |||
| NCT01455441 | A2 | PLACEBO | 16 | arm, events | 0 / 16 | R0010221:Results | |||
| NCT03311724 | A1 | PLACEBO | 16 | arm, events | 0 / 26 | R0010282:Table 2 | |||
| NCT03311724 | A2+A3+A4 | TIRZ_SC | 16 | arm, events | 0 / 85 | arms_combined | R0010282:Table 2 | ||
| NCT04466904 | A2+A3 | MAZD_SC | 20 | arm, events | 0 / 16 | arms_combined | R0009340:Table 2 | ||
| NCT04466904 | A4 | DULA_SC | 20 | arm, events | 0 / 6 | printed_denominator | R0009340:Table 2 | ||
| NCT04466904 | A5 | PLACEBO | 20 | arm, events | 0 / 12 | printed_denominator | R0009340:Table 2 | ||
| NCT00700817 | A1+A2 | LIRA_SC | 52 | arm, events | 0 / 446 | arms_combined | R0024199:Table 2 | ||
| NCT00700817 | A3 | SITAGLIPTIN | 52 | arm, events | 0 / 219 | R0024199:Table 2 | |||
| S002858 | A1 | LIXI_SC | 24 | arm, events | 0 / 51 | R0001573:Supplement Table S2 | |||
| S002858 | A2 | PLACEBO | 24 | arm, events | 0 / 50 | R0001573:Supplement Table S2 | |||
| S002885 | A1 | DULA_SC | 12 | arm, events | 0 / 13 | R0003420:Results | |||
| S002885 | A2 | EMPAGLIFLOZIN | 12 | arm, events | 0 / 12 | R0003420:Results | |||
| S002928 | A1 | PLACEBO | 24 | arm, events | 0 / 41 | R0007034:Results | |||
| S002928 | A2+A3 | PEGLOX_SC | 24 | arm, events | 0 / 82 | arms_combined | R0007034:Results | ||
| S002984 | A1 | PEGLOX_SC | 24 | arm, events | 0 / 39 | R0011969:Supplement Table S2 | |||
| S002984 | A2 | INS_GLARGINE | 24 | arm, events | 0 / 39 | R0011969:Supplement Table S2 | |||
| S002992 | A1 | IGLARLIXI_SC | 26.43 | arm, events | 0 / 443 | R0010673:Results | |||
| S002992 | A2 | INS_PREMIX | 26.43 | arm, events | 0 / 444 | R0010673:Results | |||
| S003047 | A1+A2 | LIXI_SC | 6.57 | arm, events | 0 / 80 | printed_denominator;arms_combined | R0016337:Results | ||
| S003047 | A3 | PLACEBO | 6.57 | arm, events | 0 / 40 | printed_denominator | R0016337:Results | ||
| S003079 | A1 | EXEN_SC | 5 | arm, events | 0 / 18 | R0025923:Results | |||
| S003079 | A2 | STANDARD_CARE | 5 | arm, events | 0 / 18 | R0025923:Results |
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