Study S001707

Neurodegenerative Changes in Alzheimer's Disease: Identifying Potential Effects of Liraglutide on Degenerative Changes

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

Included trial: extracted data ClinicalTrials.gov record

Registration

Registration: NCT01469351
Study type: INTERVENTIONAL
Allocation: RANDOMIZED
Masking: QUADRUPLE
Status: COMPLETED
Enrollment: 34
Start: 2012-01
Primary completion: 2013-04
Lead sponsor: University of Aarhus
Conditions: Alzheimers Disease
Interventions: DRUG:Liraglutide; DRUG:non-active study drug
Results posted: FALSE

Registered primary outcomes

PIB PET scan [PIB PET-scan at baseline and after 26 weeks]

Linked records (7)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.

Record	Title	Year	Design	Identifiers	Link basis
R0018678	Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes. Muscogiuri G, Trends in endocrinology and metabolism: TEM	2017	Narrative review	PMID 27871675 DOI	cites ClinicalTrials.gov:NCT01469351; registry reference DERIVED:27871675
R0055239	Poster Viewing Session I Thompson, G.J., Journal of Cerebral Blood Flow & Metabolism	2017	Randomized trial	PMID 28366130 DOI	cites ClinicalTrials.gov:NCT01469351
R0055328	Poster Viewing Session II O. Henriksen, Journal of Cerebral Blood Flow & Metabolism	2017	Randomized trial	PMID 28366134 DOI	cites ClinicalTrials.gov:NCT01469351
R0055624	The Niels Lassen Award Session and Oral Sessions Wong, D.F., Journal of Cerebral Blood Flow & Metabolism	2017	Randomized trial	PMID 28366133 DOI	cites ClinicalTrials.gov:NCT01469351
R0022711	In Alzheimer's Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial. Gejl M, Frontiers in aging neuroscience	2016	Randomized trial	PMID 27252647 DOI	cites ClinicalTrials.gov:NCT01469351; registry reference DERIVED:27252647
R0024799	Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer´s disease - protocol for a controlled, randomized double-blinded trial. Egefjord L, Danish medical journal	2012	Protocol	PMID 23158895	cites ClinicalTrials.gov:NCT01469351; registry reference DERIVED:23158895
R0027896	Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease. Abbas T, Behavioural brain research	2009	Preclinical	PMID 19573562 DOI	registry reference BACKGROUND:19573562