parallel randomized trial
NCT01469351
Neurodegenerative Changes in Alzheimer's Disease: Identifying Potential Effects of Liraglutide on Degenerative Changes
Design
Conduct and analysis
Arms
| Arm | Treatment | Background | Randomized | Analyzed | Completed treatment |
|---|---|---|---|---|---|
| A1 | Placebo Placebo | usual medication including cholinesterase inhibitors; lifestyle: not reported | 20 | 18 | |
| A2 | Liraglutide 1.8 mg subcutaneous once daily Liraglutide 1.8 mg | usual medication including cholinesterase inhibitors; lifestyle: not reported | 18 | 13 |
Baseline characteristics
As printed in the trial reports or registry, per arm or for the whole trial.
| Characteristic | Statistic | Placebo A1 | Liraglutide 1.8 mg subcutaneous once daily A2 |
|---|---|---|---|
| age | max (years) | 80 | |
| age | mean (years) | 66.6 | 65.4 |
| age | min (years) | 50 | |
| age | se (years) | 1.8 | |
| bmi | mean (kg/m2) | 25.1 | 25.1 |
| bmi | se (kg/m2) | 0.7 | 1.0 |
| female | n | 5 | 8 |
| female | percent | 25 | 57 |
| sbp | mean (mmHg) | 149.7 | 144.1 |
| sbp | se (mmHg) | 4.3 | 6.3 |
| weight | mean (kg) | 77.8 | 74.1 |
| weight | se (kg) | 3.0 | 2.1 |
Results
9 adjudicated result lines, grouped by outcome. Open an outcome to see its values.
Discontinuation due to adverse events (6 lines; O26)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 0 / 20 | not stated; randomized; R0022711:Results | ||||
| A1 | events | 0 / 20 | not stated; randomized; R0022711:Results | ||||
| A2 | events | 1 / 18 | not stated; randomized; R0022711:Results | ||||
| A2 | events | 1 / 18 | not stated; randomized; cancer of the bladder; R0022711:Results | ||||
| A2 | events | 1 / 18 | not stated; randomized; nausea and anorexia; R0022711:Results | ||||
| A2 | events | 1 / 18 | not stated; randomized; nausea, vomiting, and fever; R0022711:Results |
Discontinuation due to gastrointestinal adverse events (3 lines; O27E)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 0 / 20 | not stated; randomized; R0022711:Results | ||||
| A2 | events | 1 / 18 | not stated; randomized; nausea and anorexia; R0022711:Results | ||||
| A2 | events | 1 / 18 | not stated; randomized; nausea, vomiting, and fever; R0022711:Results |