parallel randomized trial

S003153

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

Heart failure with left ventricular ejection fraction above 40 percentS003153

Design

Randomized: 360
Start year: 2024
Treatment: 24 weeks, follow-up 24 weeks
Countries: China (1 sites)
Sponsor: (non industry)
Eligibility: age 18 to 75; BMI 30 or more; LVEF 50 percent or more; elevated NT-proBNP

Conduct and analysis

Blinding: not reported
Sequence generation: not reported
Allocation concealment: central
Outcome adjudication: not reported
Primary estimand: not stated
Analysis population
Missing data

Arms

Arm	Treatment	Background	Randomized	Analyzed
A1	liraglutide and dapagliflozin Dapagliflozin plus liraglutide	lifestyle: not reported	120	120
A2	Dapagliflozin Dapagliflozin	lifestyle: not reported	120	120
A3	Liraglutide 1.8 mg subcutaneous once daily Liraglutide	lifestyle: not reported	120	120

Baseline characteristics

As printed in the trial reports or registry, per arm or for the whole trial.

Characteristic	Statistic	Dapagliflozin plus liraglutide A1	Dapagliflozin A2	Liraglutide 1.8 mg subcutaneous once daily A3
age	mean (years)	57.2	56.8	57.0
age	sd (years)	10.5	9.8	10.3
bmi	mean (kg/m2)	32.6	32.4	32.7
bmi	sd (kg/m2)	2.9	2.7	2.8
egfr	mean (mL/min/1.73 m2)	87.5	88.2	87.8
egfr	sd (mL/min/1.73 m2)	15.2	14.9	15.0
hba1c	mean (percent)	7.5	7.5	7.6
hba1c	sd (percent)	1.0	0.9	1.0
other male	percent	52.5	50.8	53.3
sbp	mean (mmHg)	145.3	144.8	145.0
sbp	sd (mmHg)	15.5	15.2	15.3
weight	mean (kg)	89.5	89.7	89.6
weight	sd (kg)	11.1	11.3	11.2

Results

6 adjudicated result lines, grouped by outcome. Open an outcome to see its values.

All cause mortality (3 lines; O20)

Arm	Statistic	Events / N	Detail
A1	events	2 / 120	not stated; randomized; R0015246:Table 3
A2	events	6 / 120	not stated; randomized; R0015246:Table 3
A3	events	5 / 120	not stated; randomized; R0015246:Table 3

Hospitalization for heart failure (3 lines; O23)

Arm	Statistic	Events / N	Detail
A1	events	6 / 120	not stated; randomized; R0015246:Table 3
A2	events	13 / 120	not stated; randomized; R0015246:Table 3
A3	events	11 / 120	not stated; randomized; R0015246:Table 3