parallel randomized trial

S003138

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

Other conditionsS003138

Design

Randomized: 48
Start year
Treatment: , follow-up 4 weeks
Countries
Sponsor: (mixed)
Eligibility: healthy men 18 to 40 years; BMI 18 to 29.9

Conduct and analysis

Blinding: double blind
Sequence generation: not reported
Allocation concealment: not reported
Outcome adjudication: not reported
Primary estimand: not stated
Analysis population
Missing data

Arms

Arm	Treatment	Background	Randomized	Analyzed
A1	Placebo Placebo	lifestyle: not reported	12	12
A2	GLP-1-gFc GLP-1-gFc 0.01 mg/kg	lifestyle: not reported	6	6
A3	GLP-1-gFc GLP-1-gFc 0.02 mg/kg	lifestyle: not reported	6	6
A4	GLP-1-gFc GLP-1-gFc 0.04 mg/kg	lifestyle: not reported	6	6
A5	GLP-1-gFc GLP-1-gFc 0.08 mg/kg	lifestyle: not reported	6	6
A6	GLP-1-gFc GLP-1-gFc 0.16 mg/kg	lifestyle: not reported	6	6
A7	GLP-1-gFc GLP-1-gFc 0.24 mg/kg	lifestyle: not reported	6	6

Baseline characteristics

As printed in the trial reports or registry, per arm or for the whole trial.

Characteristic	Statistic	Placebo A1	GLP-1-gFc 0.01 mg/kg A2	GLP-1-gFc 0.02 mg/kg A3	GLP-1-gFc 0.04 mg/kg A4	GLP-1-gFc 0.08 mg/kg A5	GLP-1-gFc 0.16 mg/kg A6	GLP-1-gFc 0.24 mg/kg A7	Whole trial ALL
age	mean (years)	27.5	33.3	26.8	29.2	34.7	25.0	31.4
age	sd (years)	7.1	3.6	7.3	3.5	4.6	4.0	5.0
asian	n								1
black	n								1
bmi	mean (kg/m2)	23.43	23.03	24.65	25.93	25.80	23.53	25.78
bmi	sd (kg/m2)	3.19	3.38	2.58	3.63	2.06	4.12	2.84
other male	n								48
weight	mean (kg)	73.2	74.4	77.3	87.1	78.9	75.3	83.3
weight	sd (kg)	6.9	9.4	11.3	14.9	6.3	12.3	8.4
white	n								46

Results

25 adjudicated result lines, grouped by outcome. Open an outcome to see its values.

Nausea (7 lines; O27A)

Arm	Statistic	Events / N	Detail
A1	events	0 / 12	not stated; randomized; R0008337:Figure 6D
A2	events	0 / 6	not stated; randomized; R0008337:Figure 6D
A3	events	0 / 6	not stated; randomized; R0008337:Figure 6D
A4	events	1 / 6	not stated; randomized; R0008337:Results
A5	events	0 / 6	not stated; randomized; R0008337:Figure 6D
A6	events	0 / 6	not stated; randomized; R0008337:Figure 6D
A7	events	4 / 6	not stated; randomized; R0008337:Results

Vomiting (7 lines; O27B)

Arm	Statistic	Events / N	Detail
A1	events	0 / 12	not stated; randomized; R0008337:Figure 6D
A2	events	0 / 6	not stated; randomized; R0008337:Figure 6D
A3	events	0 / 6	not stated; randomized; R0008337:Figure 6D
A4	events	0 / 6	not stated; randomized; R0008337:Supplement Table S2
A5	events	0 / 6	not stated; randomized; R0008337:Figure 6D
A6	events	0 / 6	not stated; randomized; R0008337:Figure 6D
A7	events	1 / 6	not stated; randomized; R0008337:Results

Diarrhea (7 lines; O27C)

Arm	Statistic	Events / N	Detail
A1	events	0 / 12	not stated; randomized; R0008337:Supplement Table S2
A2	events	0 / 6	not stated; randomized; R0008337:Supplement Table S2
A3	events	0 / 6	not stated; randomized; R0008337:Supplement Table S2
A4	events	1 / 6	not stated; randomized; R0008337:Supplement Table S2
A5	events	0 / 6	not stated; randomized; R0008337:Supplement Table S2
A6	events	0 / 6	not stated; randomized; R0008337:Supplement Table S2
A7	events	2 / 6	not stated; randomized; R0008337:Supplement Table S2

Constipation (4 lines; O27D)

Arm	Statistic	Events / N	Detail
A2	events	0 / 6	not stated; randomized; R0008337:Supplement Table S2
A3	events	0 / 6	not stated; randomized; R0008337:Supplement Table S2
A5	events	0 / 6	not stated; randomized; R0008337:Supplement Table S2
A6	events	0 / 6	not stated; randomized; R0008337:Supplement Table S2