parallel randomized trial

S003130

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

Type 2 diabetes (adults)Chronic kidney disease with diabetesS003130

Design

Randomized: 199
Start year: 2024
Treatment: 12 weeks, follow-up 12 weeks
Countries: China (1 sites)
Sponsor: (non industry)
Eligibility: age 15 to 75; BMI 18.5 to 40; HbA1c 7.5 to 10 percent; UACR 30 to 300 mg/g; eGFR 60 or more

Conduct and analysis

Blinding: single blind
Sequence generation: computer
Allocation concealment: central
Outcome adjudication: not reported
Primary estimand: not stated
Analysis population: completers
Missing data: completers only

Arms

Arm	Treatment	Background	Randomized	Analyzed
A1	Standard care or no added treatment Control group	metformin 500 mg twice daily; lifestyle: not reported	66	63
A2	Insulin Insulin group	metformin 500 mg twice daily; lifestyle: not reported	71	71
A3	GLP-1 receptor agonist (agent not reported) GLP-1 receptor agonist group	metformin 500 mg twice daily; lifestyle: not reported	62	57

Baseline characteristics

As printed in the trial reports or registry, per arm or for the whole trial.

Characteristic	Statistic	Standard care or no added treatment A1	Insulin A2	GLP-1 receptor agonist group A3
age	mean (years)	60.13		52.75
age	median (years)		61.00
age	q1 (years)		50.75
age	q3 (years)		71.00
age	sd (years)	10.24		15.24
bmi	mean (kg/m2)	25.82
bmi	median (kg/m2)		26.53	27.18
bmi	q1 (kg/m2)		24.37	25.00
bmi	q3 (kg/m2)		30.07	29.83
bmi	sd (kg/m2)	3.14
diabetes duration	median (years)	10.00	10.00	7.50
diabetes duration	q1 (years)	6.00	3.00	4.00
diabetes duration	q3 (years)	20.00	17.00	12.75
egfr	mean (mL/min/1.73 m2)	91.52		91.03
egfr	median (mL/min/1.73 m2)		100.92
egfr	q1 (mL/min/1.73 m2)		94.32
egfr	q3 (mL/min/1.73 m2)		115.56
egfr	sd (mL/min/1.73 m2)	18.81		21.74
hba1c	mean (percent)			8.39
hba1c	median (percent)	7.75	9.35
hba1c	q1 (percent)	6.98	8.00
hba1c	q3 (percent)	8.70	11.05
hba1c	sd (percent)			1.44
other male	percent	63.5	49.3	31.6
uacr	median (mg/g)	38.95	39.15	39.44
uacr	q1 (mg/g)	33.22	35.06	35.52
uacr	q3 (mg/g)	76.89	53.62	48.50
weight	mean (kg)	72.93
weight	median (kg)		73.50	76.50
weight	q1 (kg)		66.75	65.00
weight	q3 (kg)		85.00	87.00
weight	sd (kg)	11.60

Results

3 adjudicated result lines, grouped by outcome. Open an outcome to see its values.

HbA1c change (3 lines; O01)

Week	Arm	Statistic	Estimate	SE or SD	Events / N	Detail
12	A1	final	6.74 percent	0.97	63	not stated; completers; R0004335:Table 2A
12	A2	final	7.16 percent	1.05	71	not stated; completers; R0004335:Table 2A
12	A3	final	6.72 percent	0.90	57	not stated; completers; R0004335:Table 2A