parallel randomized trial

S003053

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

Type 2 diabetes (adults)S003053

Design

Randomized: 31
Start year: 2011
Treatment: 14 weeks, follow-up 14 weeks
Countries: Japan (7 sites)
Sponsor: Hokkaido Diabetes Clinical Research Organization (non industry)
Eligibility: T2D; age 20 to 75; HbA1c 7.4 to 10.5 percent; no atherosclerotic disease; no insulin

Conduct and analysis

Blinding: open label
Sequence generation: computer
Allocation concealment: not reported
Outcome adjudication: not reported
Primary estimand: not stated
Analysis population: randomized
Missing data

Arms

Arm	Treatment	Background	Randomized	Analyzed	Completed treatment
A1	liraglutide Liraglutide	metformin and or sulfonylurea or DPP-4 inhibitor; lifestyle: standard	16	16
A2	Insulin glargine Insulin glargine	metformin and or sulfonylurea or DPP-4 inhibitor; lifestyle: standard	15	15

Baseline characteristics

As printed in the trial reports or registry, per arm or for the whole trial.

Characteristic	Statistic	Liraglutide A1	Insulin glargine A2
age	mean (years)	61.1	59.5
age	sd (years)	8.3	12.3
bmi	median (kg/m2)	26.6	25.8
bmi	q1 (kg/m2)	23.6	24.2
bmi	q3 (kg/m2)	29.9	28.2
hba1c	mean (percent)	8.6	8.7
hba1c	sd (percent)	0.8	0.8
metformin use	percent	100	93.3
other dpp4i use	percent	43.8	66.7
other male	percent	75.0	46.7
other sulfonylurea use	percent	87.5	80.0
sbp	mean (mmHg)	136.0	126.4
sbp	sd (mmHg)	14.9	14.2

Results

4 adjudicated result lines, grouped by outcome. Open an outcome to see its values.

HbA1c change (2 lines; O01)

Week	Arm	Statistic	Estimate	SE or SD	95% CI	Events / N	Detail
14	A1	change	-1.20 percent		-1.54 to -0.86	16	not stated; other; R0022481:Table 3
14	A2	change	-0.65 percent		-1.34 to 0.03	15	not stated; other; R0022481:Table 3

Systolic blood pressure change (2 lines; O05)

Week	Arm	Statistic	Estimate	SE or SD	95% CI	Events / N	Detail
14	A1	change	0.3 mmHg		-11.9 to 12.5	16	not stated; other; R0022481:Table 3
14	A2	change	4.9 mmHg		-5.1 to 14.9	15	not stated; other; R0022481:Table 3