parallel randomized trial
S003022
Polycystic ovary syndromeS003022
Design
Conduct and analysis
Arms
| Arm | Treatment | Background | Randomized | Analyzed | Completed treatment |
|---|---|---|---|---|---|
| A1 | Metformin Metformin (MET) | lifestyle: not reported | 20 | 19 | |
| A2 | Liraglutide 1.2 mg subcutaneous once daily LIRA | lifestyle: not reported | 20 | 18 | |
| A3 | Liraglutide and metformin 1.2 to 0.85 mg injection once daily Liraglutide plus metformin (COM) | lifestyle: not reported | 20 | 17 |
Baseline characteristics
As printed in the trial reports or registry, per arm or for the whole trial.
| Characteristic | Statistic | Metformin A1 | Liraglutide 1.2 mg subcutaneous once daily A2 | Liraglutide and metformin 1.2 to 0.85 mg injection once daily A3 | Whole trial ALL |
|---|---|---|---|---|---|
| bmi | mean (kg/m2) | 28.10 | 27.94 | 26.68 | |
| bmi | sd (kg/m2) | 2.95 | 2.59 | 2.14 | |
| female | n | 60 | |||
| hba1c | mean (percent) | 5.35 | 5.28 | 5.26 | |
| hba1c | sd (percent) | 0.38 | 0.40 | 0.34 | |
| weight | mean (kg) | 69.20 | 67.51 | 69.24 | |
| weight | sd (kg) | 8.32 | 7.69 | 7.72 |
Analyses this trial contributes to
- NauseaPolycystic ovary syndrome; longest follow-up; network meta-analysis
- NauseaPolycystic ovary syndrome; longest follow-up; network meta-analysis
- VomitingPolycystic ovary syndrome; longest follow-up; descriptive only
- VomitingPolycystic ovary syndrome; longest follow-up; network meta-analysis
- DiarrheaPolycystic ovary syndrome; longest follow-up; network meta-analysis
- DiarrheaPolycystic ovary syndrome; longest follow-up; network meta-analysis
Results
19 adjudicated result lines, grouped by outcome. Open an outcome to see its values.
Percent body weight change (short trials) (3 lines; O10B)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| 12 | A1 | percent change | -5.28 percent | 19 | not stated; completers; R0015954:Results | ||
| 12 | A2 | percent change | -7.71 percent | 18 | not stated; completers; R0015954:Results | ||
| 12 | A3 | percent change | -10.55 percent | 17 | not stated; completers; R0015954:Results |
Discontinuation due to adverse events (3 lines; O26)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 1 / 20 | not stated; randomized; R0015954:Figure 1 | ||||
| A2 | events | 2 / 20 | not stated; randomized; R0015954:Figure 1 | ||||
| A3 | events | 3 / 20 | not stated; randomized; R0015954:Figure 1 |
Nausea (3 lines; O27A)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 6 / 19 | not stated; completers; R0015954:Results | ||||
| A2 | events | 9 / 18 | not stated; completers; R0015954:Results | ||||
| A3 | events | 9 / 17 | not stated; completers; R0015954:Results |
Vomiting (3 lines; O27B)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 4 / 19 | not stated; completers; R0015954:Results | ||||
| A2 | events | 3 / 18 | not stated; completers; R0015954:Results | ||||
| A3 | events | 5 / 17 | not stated; completers; R0015954:Results |
Diarrhea (3 lines; O27C)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 4 / 19 | not stated; completers; R0015954:Results | ||||
| A2 | events | 4 / 18 | not stated; completers; R0015954:Results | ||||
| A3 | events | 6 / 17 | not stated; completers; R0015954:Results |
Constipation (1 lines; O27D)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A3 | events | 1 / 17 | not stated; completers; R0015954:Results |
Discontinuation due to gastrointestinal adverse events (3 lines; O27E)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| A1 | events | 1 / 20 | not stated; randomized; vomiting; R0015954:Figure 1 | ||||
| A3 | events | 1 / 20 | not stated; randomized; diarrhea; R0015954:Figure 1 | ||||
| A3 | events | 2 / 20 | not stated; randomized; vomiting; R0015954:Figure 1 |