parallel randomized trial

S003016

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

Type 2 diabetes (adults)S003016

Design

Randomized: 36
Start year: 2019
Treatment: 16 weeks, follow-up 16 weeks
Countries: China (1 sites)
Sponsor: (non industry)
Eligibility: age 40 to 75; HbA1c 7.0 to 10.0 percent on metformin at least 1500 mg daily

Conduct and analysis

Blinding: open label
Sequence generation: computer
Allocation concealment: central
Outcome adjudication: not reported
Primary estimand: not stated
Analysis population: randomized
Missing data

Arms

Arm	Treatment	Background	Randomized	Analyzed
A1	Dapagliflozin Dapagliflozin plus metformin	metformin at least 1500 mg daily; lifestyle: not reported	12	12
A2	Liraglutide 1.8 mg subcutaneous once daily Liraglutide plus metformin	metformin at least 1500 mg daily; lifestyle: not reported	12	12
A3	Acarbose Acarbose plus metformin	metformin at least 1500 mg daily; lifestyle: not reported	12	12

Baseline characteristics

As printed in the trial reports or registry, per arm or for the whole trial.

Characteristic	Statistic	Dapagliflozin A1	Liraglutide 1.8 mg subcutaneous once daily A2	Acarbose A3
age	mean (years)	57.0	51.9	56.4
age	sd (years)	9.5	10.2	8.9
bmi	mean (kg/m2)	26.7	27.3	27.2
bmi	sd (kg/m2)	1.2	1.6	1.9
diabetes duration	mean (years)	8.5	7.8	6.6
diabetes duration	sd (years)	8.4	5.0	4.4
female	n	7	6	5
female	percent	58.3	50.0	41.7
hba1c	mean (percent)	8.2	8.5	7.9
hba1c	sd (percent)	1.0	1.0	0.9
sbp	mean (mmHg)	135.9	136.2	134.8
sbp	sd (mmHg)	7.8	14.5	15.2
waist	mean (cm)	97.3	94.8	93.0
waist	sd (cm)	5.4	6.8	7.6
weight	mean (kg)	74.6	73.7	73.4
weight	sd (kg)	8.1	8.6	6.8

Results

9 adjudicated result lines, grouped by outcome. Open an outcome to see its values.

HbA1c change (3 lines; O01)

Week	Arm	Statistic	Estimate	SE or SD	Events / N	Detail
16	A1	final	7.0 percent	1.2	12	not stated; randomized; R0016968:Table 1
16	A2	final	7.1 percent	0.7	12	not stated; randomized; R0016968:Table 1
16	A3	final	7.1 percent	0.7	12	not stated; randomized; R0016968:Table 1

Body weight change in kilograms (diabetes) (3 lines; O02)

Week	Arm	Statistic	Estimate	SE or SD	Events / N	Detail
16	A1	final	71.8 kg	7.8	12	not stated; randomized; R0016968:Table 1
16	A2	final	71.3 kg	9.1	12	not stated; randomized; R0016968:Table 1
16	A3	final	71.7 kg	5.9	12	not stated; randomized; R0016968:Table 1

Systolic blood pressure change (3 lines; O05)

Week	Arm	Statistic	Estimate	SE or SD	Events / N	Detail
16	A1	final	132.8 mmHg	7.2	12	not stated; randomized; R0016968:Table 1
16	A2	final	136.7 mmHg	11.6	12	not stated; randomized; R0016968:Table 1
16	A3	final	130.1 mmHg	14.9	12	not stated; randomized; R0016968:Table 1