parallel randomized trial
S002949
Type 2 diabetes (adults)S002949
Design
Conduct and analysis
Arms
| Arm | Treatment | Background | Randomized | Analyzed | Completed treatment |
|---|---|---|---|---|---|
| A1 | liraglutide or dulaglutide (continued) Continue liraglutide or dulaglutide | metformin, SGLT2 inhibitors, insulin and other drugs; lifestyle: standard | |||
| A2 | semaglutide Switch to semaglutide once weekly | metformin, SGLT2 inhibitors, insulin and other drugs; lifestyle: standard |
Baseline characteristics
As printed in the trial reports or registry, per arm or for the whole trial.
| Characteristic | Statistic | Continue liraglutide or dulaglutide A1 | Switch to semaglutide once weekly A2 |
|---|---|---|---|
| age | mean (years) | 56.3 | 61.2 |
| age | sd (years) | 11.6 | 12.8 |
| bmi | mean (kg/m2) | 30.8 | 31.1 |
| bmi | sd (kg/m2) | 4.2 | 5.4 |
| diabetes duration: 5 to 15 | n | 11 | 9 |
| diabetes duration: 5 to 15 | percent | 40.7 | 29.0 |
| diabetes duration: less than 5 | n | 2 | 1 |
| diabetes duration: less than 5 | percent | 7.4 | 3.2 |
| diabetes duration: more than 15 | n | 14 | 21 |
| diabetes duration: more than 15 | percent | 51.9 | 69.7 |
| egfr | mean (mL/min/1.73 m2) | 70.9 | 71.8 |
| egfr | sd (mL/min/1.73 m2) | 22.5 | 22.6 |
| female | n | 15 | 12 |
| female | percent | 55.6 | 38.7 |
| hba1c | mean (percent) | 7.8 | 8.0 |
| hba1c | sd (percent) | 0.9 | 0.7 |
| insulin use | n | 11 | 13 |
| insulin use | percent | 40.7 | 41.9 |
| metformin use | n | 25 | 28 |
| metformin use | percent | 92.6 | 90.3 |
| other alpha glucosidase inhibitor use | n | 5 | 2 |
| other alpha glucosidase inhibitor use | percent | 18.5 | 6.5 |
| other glinide use | n | 5 | 2 |
| other glinide use | percent | 18.5 | 6.5 |
| other sulfonylurea use | n | 6 | 7 |
| other sulfonylurea use | percent | 22.2 | 22.6 |
| other thiazolidinedione use | n | 3 | 7 |
| other thiazolidinedione use | percent | 11.1 | 21.6 |
| sbp | mean (mmHg) | 128.4 | 129.6 |
| sbp | sd (mmHg) | 13.1 | 13.1 |
| sglt2i use | n | 24 | 27 |
| sglt2i use | percent | 88.9 | 87.1 |
| uacr: macroalbuminuria | n | 4 | 5 |
| uacr: macroalbuminuria | percent | 14.8 | 16.1 |
| uacr: microalbuminuria | n | 5 | 7 |
| uacr: microalbuminuria | percent | 18.5 | 22.6 |
| waist | mean (cm) | 103.4 | 105.4 |
| waist | sd (cm) | 11.4 | 12.9 |
Results
2 adjudicated result lines, grouped by outcome. Open an outcome to see its values.
HbA1c change (2 lines; O01)
| Week | Arm | Statistic | Estimate | SE or SD | 95% CI | Events / N | Detail |
|---|---|---|---|---|---|---|---|
| 24 | A1 | change | 0.1 percent | -0.1 to 0.3 | 27 | not stated; other; fli:ge30_nondrinker; R0004843:Table 2 | |
| 24 | A2 | change | -0.8 percent | -1.1 to -0.6 | 31 | not stated; other; fli:ge30_nondrinker; R0004843:Table 2 |