LivingGLP1
Descriptive only

Percent body weight change (short trials)

Antipsychotic associated weight gain and severe mental illness

weeks 12 to 52 (target week 24)Not stated by the trialsEach dose separatelyMean difference
1
Randomized trials
2
Treatments
0
Participants
2
Trial arms

In plain language

No network meta-analysis was fitted here. The protocol requires at least two trials forming a connected network; this outcome has 1 trial. The trial data below are shown as reported.

Network of trials

Each circle is a treatment; each line joins treatments that were randomized against each other in at least one trial.
PLACEBOSEMA_SC_2p0MG_QW
Node area shows participants; line width shows trials comparing two treatments directly. Blue: GLP-1 receptor agonist containing treatments; grey: comparators. Hover over or tab to a node or line for details.

Comparability of the trials

Checked across designs (the set of treatments each trial compares) for eligibility, outcome definition and assessment, and the baseline factors above. Flags point to possible intransitivity; notes describe variation that is not tied to design.

No comparability concerns were found.

Comparability items per trial
Trialtime weeksanalysis setdefinitioninstrumentadjudicatedproportion methodintercurrent events (discontinuation)intercurrent events (rescue)blindingfundingstart yearEligibility
S00300236otherPercent body weight change, least squares meannot statednot statednot statednot statednot stateddouble_blindnot_reportedage 18 or older; schizophrenia or schizoaffective on clozapine 18 weeks or more; BMI 26 or more

Trial data

What each trial contributes. Arm rows give the arm value with its standard error, or events over participants; contrast rows give the mean difference on the analysis scale against the trial's first row. Flags mark converted, combined or approximated inputs.
Trial data entering this analysis
TrialArmTreatmentWeekDataValueSEEvents / NFlagsSource
S003002A1SEMA_SC_2p0MG_QW36arm, percent_change-13.8800.900R0012753:Abstract
S003002A2PLACEBO36arm, percent_change-0.4200.930R0012753:Abstract

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