Descriptive only

Apnea hypopnea index change

Obstructive sleep apnea

weeks 24 to 64 (target week 52)Not stated by the trialsEach dose separatelyMean difference

Randomized trials

Treatments

359

Participants

Trial arms

In plain language

No network meta-analysis was fitted here. The protocol requires at least two trials forming a connected network; this outcome has 1 trial. The trial data below are shown as reported.

Network of trials

Each circle is a treatment; each line joins treatments that were randomized against each other in at least one trial.

Node area shows participants; line width shows trials comparing two treatments directly. Blue: GLP-1 receptor agonist containing treatments; grey: comparators. Hover over or tab to a node or line for details.

Baseline characteristics of the trials

The baseline value of each effect modifier or prognostic factor that applies here, per trial: mean or percent over arms, weighted by the number randomized. A note under a value names a stand in (a median for a mean, 100 minus the male share, Asian subgroup rows, an all Asian site list); "not reported" means no source of the trial prints it.

Baseline effect modifiers and prognostic factors per trial
Trial	Baseline AHI and airway pressure use (events per hour) effect modifier, prognostic factor; 1 of 1
NCT01557166 S002315	49.15

Comparability of the trials

Checked across designs (the set of treatments each trial compares) for eligibility, outcome definition and assessment, and the baseline factors above. Flags point to possible intransitivity; notes describe variation that is not tied to design.

NoteData handling, input conversions: n_randomized 2

Comparability items per trial
Trial	time weeks	analysis set	definition	instrument	adjudicated	proportion method	intercurrent events (discontinuation)	intercurrent events (rescue)	blinding	funding	start year	Eligibility
NCT01557166	32	full_analysis	not stated	not stated	not stated	not stated	not stated	not stated	double_blind	industry	2012	age 18 to 64; BMI 30 or more; AHI 15 or more; no diabetes; unable or unwilling to use CPAP

Trial data

What each trial contributes. Arm rows give the arm value with its standard error, or events over participants; contrast rows give the mean difference on the analysis scale against the trial's first row. Flags mark converted, combined or approximated inputs.

Trial data entering this analysis
Trial	Arm	Treatment	Week	Data	Value	SE	Events / N	Flags	Source
NCT01557166	A1	LIRA_SC_3p0MG_QD	32	arm, change	-12.200	1.800	180	n_randomized	R0026203:Results
NCT01557166	A2	PLACEBO	32	arm, change	-6.100	2.000	179	n_randomized	R0026203:Results

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