LivingGLP1
Descriptive only

Thyroid cancer (any)

Chronic kidney disease with diabetes

longest follow-upRecorded harmsEach dose separatelyHazard ratio (from event counts)Separate part 2 of a disconnected network
1
Randomized trials
3
Treatments
281
Participants
0
Events

In plain language

No network meta-analysis was fitted here. The protocol requires at least two trials forming a connected network; this outcome has 1 trial. The trial data below are shown as reported.

Network of trials

Each circle is a treatment; each line joins treatments that were randomized against each other in at least one trial.
HRS7535_PO_30MG_QDHRS7535_PO_90MG_QDPLACEBO
Node area shows participants; line width shows trials comparing two treatments directly. Blue: GLP-1 receptor agonist containing treatments; grey: comparators. Hover over or tab to a node or line for details.

Comparability of the trials

Checked across designs (the set of treatments each trial compares) for eligibility, outcome definition and assessment, and the baseline factors above. Flags point to possible intransitivity; notes describe variation that is not tied to design.

No comparability concerns were found.

Comparability items per trial
Trialtime weeksanalysis setdefinitioninstrumentadjudicatedproportion methodintercurrent events (discontinuation)intercurrent events (rescue)blindingfundingstart yearEligibility
SOLID-DKD18safetylevel 3 severe hypoglycemianot statednot statednot statednot statednot stateddouble_blindindustry2024age 18 to 75; T2D with UACR 300 to below 3000 mg/g; eGFR 30 or more; HbA1c 6.5 to 10; BMI 20 to 40

Trial data

What each trial contributes. Arm rows give the arm value with its standard error, or events over participants; contrast rows give the hazard ratio (from event counts) on the analysis scale (log) against the trial's first row. Flags mark converted, combined or approximated inputs.
Trial data entering this analysis
TrialArmTreatmentWeekDataValueSEEvents / NFlagsSource
SOLID-DKDA1HRS7535_PO_30MG_QD18arm, events0 / 93R0004355:Table 2
SOLID-DKDA2HRS7535_PO_90MG_QD18arm, events0 / 94R0004355:Table 2
SOLID-DKDA3PLACEBO18arm, events0 / 94R0004355:Table 2

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