Descriptive only
Serious adverse events
Prediabetes or impaired glucose regulation
longest follow-upRecorded harmsEach dose separatelyHazard ratio (from event counts)
1
Randomized trials
4
Treatments
267
Participants
17
Events
In plain language
No network meta-analysis was fitted here. The protocol requires at least two trials forming a connected network; this outcome has 1 trial. The trial data below are shown as reported.
Network of trials
Each circle is a treatment; each line joins treatments that were randomized against each other in at least one trial.
Comparability of the trials
Checked across designs (the set of treatments each trial compares) for eligibility, outcome definition and assessment, and the baseline factors above. Flags point to possible intransitivity; notes describe variation that is not tied to design.
No comparability concerns were found.
| Trial | time weeks | analysis set | definition | instrument | adjudicated | proportion method | intercurrent events (discontinuation) | intercurrent events (rescue) | blinding | funding | start year | Eligibility |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RISE Adult | 65.175 | randomized | not stated | not stated | not stated | not stated | not stated | not stated | open_label | non_industry | 2013 | age 20 to 65; BMI 25 to under 50; IGT or drug naive type 2 diabetes under 12 months; HbA1c 7 or lower |
Trial data
What each trial contributes. Arm rows give the arm value with its standard error, or events over participants; contrast rows give the hazard ratio (from event counts) on the analysis scale (log) against the trial's first row. Flags mark converted, combined or approximated inputs.
| Trial | Arm | Treatment | Week | Data | Value | SE | Events / N | Flags | Source |
|---|---|---|---|---|---|---|---|---|---|
| RISE Adult | A1 | METFORMIN | 65.175 | arm, events | 5 / 65 | registry:adverse_events | |||
| RISE Adult | A2 | OTHER_ACTIVE_glargine_then_metformin | 65.175 | arm, events | 2 / 67 | registry:adverse_events | |||
| RISE Adult | A3 | PLACEBO | 65.175 | arm, events | 3 / 67 | registry:adverse_events | |||
| RISE Adult | A4 | LIRA_SC_MTD_0p6-1p2-1p8_QD | 65.175 | arm, events | 7 / 68 | registry:adverse_events |
Rerun this analysis yourself
Remove treatments or trials and refit the frequentist and Bayesian models in your browser, with the same methods as the published analysis.