Study S003236

Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Overweight or Obesity, and Obstructive Sleep Apnoea Treated With Positive Airway Pressure (AMAZE 4)

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

ClinicalTrials.gov record

Registration

Registration: NCT07571109
Acronym: AMAZE 4
Study type: INTERVENTIONAL
Allocation: RANDOMIZED
Phase: PHASE3
Masking: QUADRUPLE
Status: RECRUITING
Enrollment: 300
Start: 2026-05-05
Primary completion: 2028-06-26
Lead sponsor: Novo Nordisk A/S
Conditions: Obesity; Overweight; Obstructive Sleep Apnoea
Interventions: DRUG:NNC0487-0111; DRUG:Placebo (matched to NNC0487-0111)
Results posted: FALSE
Individual participant data sharing: YES
Secondary identifiers: OTHER:U1111-1313-6538; OTHER:2024-520443-16

Registered primary outcomes

Relative change in body weight [From baseline (week 0) to (week 80)]
Change in apnoea-hypopnoea index (AHI) [From baseline (week 0) to (week 80)]

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