Study S002511

Preoperative Metoclopramide to Enhance Gastric Emptying in Patients on Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss: A Randomised Controlled Trial With Ultrasound Assessment

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

ClinicalTrials.gov record

Registration

Registration: NCT07100691
Acronym: GEM-GLP1RA
Study type: INTERVENTIONAL
Allocation: RANDOMIZED
Phase: PHASE4
Masking: DOUBLE
Status: NOT_YET_RECRUITING
Enrollment: 80
Start: 2025-08
Primary completion: 2026-05
Lead sponsor: Mater Misericordiae University Hospital
Conditions: Pulmonary Aspiration During Anaesthetic Induction; Gastric Emptying Time; Preoperative Risk Assessment; Obesity (Disorder)
Interventions: DRUG:Metoclopramide
Results posted: FALSE
Individual participant data sharing: NO

Registered primary outcomes

Presence of residual gastric content on preoperative gastric ultrasound [On the day of surgery prior to anaesthesia induction]

Linked records (6)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.

Record	Title	Year	Design	Identifiers	Link basis
R0003504	Elective peri-operative management of adults taking glucagon-like peptide-1 receptor agonists, glucose-dependent insulinotropic peptide agonists and sodium-glucose cotransporter-2 inhibitors: a multidisciplinary consensus statement: A consensus statement from the Association of Anaesthetists, Association of British Clinical Diabetologists, British Obesity and Metabolic Surgery Society, Centre for Perioperative Care, Joint British Diabetes Societies for Inpatient Care, Royal College of Anaesthetists, Society for Obesity and Bariatric Anaesthesia and UK Clinical Pharmacy Association. El-Boghdadly K, Anaesthesia	2025	Other	PMID 39781571 DOI	registry reference BACKGROUND:39781571
R0003484	Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis. Yao H, BMJ (Clinical research ed.)	2024	Systematic review	PMID 38286487 DOI	registry reference BACKGROUND:38286487
R0003659	Glucagon-like peptide-1 receptor agonists in the perioperative period: Implications for the anaesthesiologist. Gariani K, European journal of anaesthesiology	2024	Randomized trial	PMID 38298102 DOI	registry reference BACKGROUND:38298102
R0004458	ASA Consensus-based Guidance on Preoperative Management of Patients on Glucagon-like Peptide-1 Receptor Agonists. Ushakumari DS, Anesthesiology	2024	Nonrandomized study	PMID 37982170 DOI	registry reference BACKGROUND:37982170
R0004588	Anesthetic Considerations in Adult Patients on Glucagon-Like Peptide-1 Receptor Agonists: Gastrointestinal Focus. Joshi GP, Anesthesia and analgesia	2024	Other	PMID 37874648 DOI	registry reference BACKGROUND:37874648
R0005108	Glucagon-Like Peptide-1 Receptor Agonist Use and Residual Gastric Content Before Anesthesia. Sen S, JAMA surgery	2024	Nonrandomized study	PMID 38446466 DOI	registry reference BACKGROUND:38446466