Study S002474

A Single-blind Randomised Study to Test the Effects of Protein-enriched Breakfast Meals With Varying Protein Sources Compared to a Standard Meal on the Regulation of Appetite and Satiety in Healthy Human Volunteers

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

ClinicalTrials.gov record

Registration

Registration: NCT07104461
Acronym: APPETITE
Study type: INTERVENTIONAL
Allocation: RANDOMIZED
Masking: SINGLE
Status: COMPLETED
Enrollment: 12
Start: 2023-06-09
Primary completion: 2024-10-31
Lead sponsor: University of Westminster
Conditions: Appetite and General Nutritional Disorders
Interventions: OTHER:Oat porridge; DIETARY_SUPPLEMENT:Whey protein isolate; DIETARY_SUPPLEMENT:Potato protein isolate; DIETARY_SUPPLEMENT:Meal replacement shake
Results posted: FALSE
Individual participant data sharing: NO

Registered primary outcomes

To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate and meal replacement shake on glucose levels (T30) [Glucose measured 30 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on glucose levels (T60) [Glucose measured 60 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on glucose levels (T120) [Glucose measured 120 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on glucose levels (T180) [Glucose measured 180 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on insulin levels (T30) [Insulin measured 30 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on insulin levels (T60) [Insulin measured 160 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on insulin levels (T120) [Insulin measured 120 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on insulin levels (T180) [Insulin measured 180 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on glucagon-like peptide 1 levels (T30) [Glucagon-like peptide 1 measured 30 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on glucagon-like peptide 1 levels (T60) [Glucagon-like peptide 1 measured 60 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on glucagon-like peptide 1 levels (T120) [Glucagon-like peptide 1 measured 120 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on glucagon-like peptide 1 levels (T180) [Glucagon-like peptide 1 measured 180 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on gastric inhibitory polypeptide (T30) [Gastric inhibitory polypeptide measured 30 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on gastric inhibitory polypeptide (T60) [Gastric inhibitory polypeptide measured 60 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on gastric inhibitory polypeptide (T120) [Gastric inhibitory polypeptide measured 120 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on gastric inhibitory polypeptide (T180) [Gastric inhibitory polypeptide measured 180 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on peptide tyrosine tyrosine levels (T30) [Peptide tyrosine tyrosine measured 30 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on peptide tyrosine tyrosine levels (T60) Markers: peptide tyrosine tyrosine (pmol/L) [Peptide tyrosine tyrosine measured 60 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on peptide tyrosine tyrosine levels (T120) [Peptide tyrosine tyrosine measured 120 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on peptide tyrosine tyrosine levels (T180) [Peptide tyrosine tyrosine measured 180 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on ghrelin levels (T30) [Ghrelin measured 30 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on ghrelin levels (T60) [Ghrelin measured 60 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on ghrelin levels (T120) [Ghrelin measured 120 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on ghrelin levels (T180) [Ghrelin measured 180 minutes post meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on appetite (T30) [Visual Analogue Scale for Appetite (VAS-A) collected 30 minutes after meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on appetite (T60) [Visual Analogue Scale for Appetite (VAS-A) collected 60 minutes after meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on appetite (T120) [Visual Analogue Scale for Appetite (VAS-A) collected 120 minutes after meal consumption]
To assess the acute effects of oat porridge, whey protein isolate, potato protein isolate, and meal replacement shake on appetite (T180) [Visual Analogue Scale for Appetite (VAS-A) collected 180 minutes after meal consumption]

Linked records (3)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.

Record	Title	Year	Design	Identifiers	Link basis
R0012969	Evaluating the benefits of the early use of GLP-1 receptor agonists. Zushin PH, Lancet (London, England)	2025	Other	PMID 39547251 DOI	registry reference BACKGROUND:39547251
R0001767	Association between different GLP-1 receptor agonists and acute pancreatitis: case series and real-world pharmacovigilance analysis. Guo H, Frontiers in pharmacology	2024	Nonrandomized study	PMID 39605914 DOI	registry reference BACKGROUND:39605914
R0007416	Safety issues with glucagon-like peptide-1 receptor agonists (pancreatitis, pancreatic cancer and cholelithiasis): Data from randomized controlled trials. Monami M, Diabetes, obesity & metabolism	2017	Systematic review	PMID 28244632 DOI	registry reference BACKGROUND:28244632