Study S002295

Randomized Trial of Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

ClinicalTrials.gov record Study Protocol and Statistical Analysis Plan: Protocol Ver. 5 (PDF)

Registration

Registration: NCT06533527
Study type: INTERVENTIONAL
Allocation: RANDOMIZED
Phase: PHASE4
Masking: DOUBLE
Status: COMPLETED
Enrollment: 69
Start: 2024-07-31
Primary completion: 2025-05-20
Lead sponsor: The Cleveland Clinic
Conditions: Diabetes Mellitus, Type 2; Obesity; Gastroparesis
Interventions: DRUG:GLP-1 medication
Results posted: TRUE

Registered primary outcomes

Presence of RGV (Residual Gastric Volume) in Stomach [Procedure]
Tracking the Use of Intubation Due to RGV [Procedure]
Aspiration Events Due to RGV (Residual Gastric Volume) [Procedure]

Linked records (3)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.

Record	Title	Year	Design	Identifiers	Link basis
R0057005	Holding vs Continuing GLP-1/GIP Agonists Before Upper Endoscopy: The OCULUS Randomized Clinical Trial. Ahmad AI, JAMA internal medicine	2026	Randomized trial	PMID 41837981 DOI	cites ClinicalTrials.gov:NCT06533527; registry reference DERIVED:41837981
R0004072	Association of glucagon-like peptide-1 receptor agonist treatment with gastric residue in an esophagogastroduodenoscopy. Kobori T, Journal of diabetes investigation	2023	Nonrandomized study	PMID 36919944 DOI	registry reference RESULT:36919944
R0009515	Relationship between perioperative semaglutide use and residual gastric content: A retrospective analysis of patients undergoing elective upper endoscopy. Silveira SQ, Journal of clinical anesthesia	2023	Nonrandomized study	PMID 36870274 DOI	registry reference RESULT:36870274