Study S002115

Role of Exenatide in Treatment of NASH-a Pilot Study

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

ClinicalTrials.gov record

Registration

Registration: NCT00650546
Acronym: NAFLD
Study type: INTERVENTIONAL
Phase: PHASE2; PHASE3
Masking: NONE
Status: COMPLETED
Enrollment: 8
Start: 2006-08
Primary completion: 2010-08
Lead sponsor: Indiana University
Conditions: Nonalcoholic Fatty Liver Disease
Interventions: DRUG:Exenatide
Results posted: TRUE
Secondary identifiers: NIH:U01DK061737

Registered primary outcomes

Number of Patients With Improvement in Liver Histology After Treatment With Exenatide [between baseline and 24-28 weeks after initiating treatment]
Change in NAS [Between baseline and 28 weeks of treatment with exenatide, sub q, 5-10 mcq.]

Linked records (5)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.

Record	Title	Year	Design	Identifiers	Link basis
R0027332	Exenatide in the treatment of diabetic patients with non-alcoholic steatohepatitis: a case series. Kenny PR, The American journal of gastroenterology	2010	Case report	PMID 21131943 DOI	registry reference RESULT:21131943
R0021796	Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes. Kolterman OG, The Journal of clinical endocrinology and metabolism	2003	Other trial	PMID 12843147 DOI	registry reference BACKGROUND:12843147
R0025908	Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations. Greig NH, Diabetologia	1999	Preclinical	PMID 10027577 DOI	registry reference BACKGROUND:10027577
R0026136	Tissue-specific expression of unique mRNAs that encode proglucagon-derived peptides or exendin 4 in the lizard. Chen YE, The Journal of biological chemistry	1997	Preclinical	PMID 9020121 DOI	registry reference BACKGROUND:9020121
R0026262	Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas. Eng J, The Journal of biological chemistry	1992	Preclinical	PMID 1313797 DOI	registry reference BACKGROUND:1313797