LivingGLP1
Study S002103

Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation: A Randomized, Controlled Trial

Registration

Registration
NCT07092618
Study type
INTERVENTIONAL
Allocation
RANDOMIZED
Phase
PHASE2; PHASE3
Masking
NONE
Status
RECRUITING
Enrollment
150
Start
2024-12-17
Primary completion
2025-08
Lead sponsor
AgelessRx
Conditions
Longevity; GLP-1; Geroscience; Aging
Interventions
DRUG:Metformin; DRUG:Rapamycin; DRUG:Naltrexone; DIETARY_SUPPLEMENT:Vitamin C
Results posted
FALSE
Individual participant data sharing
YES

Registered primary outcomes

  • Evaluate the effectiveness of metformin in maintaining GLP1-induced weight loss in participants weaning off of Ozempic or Wegovy (or compounded semaglutide equivalent) [6 months]
  • Evaluate the effectiveness of metformin + rapamycin in maintaining GLP1-induced weight loss in participants weaning off of Ozempic (or equivalent) or Wegovy (or equivalent) [6 months]
  • Evaluate the effectiveness of metformin + LDN in maintaining GLP1-induced weight loss in participants weaning off of Ozempic (or equivalent) or Wegovy (or equivalent) [6 months]

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