LivingGLP1
Study S002080

Effectiveness of the Combination Liraglutide and Metformin on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With Polycystic Ovarian Syndrome, Obesity and Infertility

ClinicalTrials.gov record

Registration

Registration
NCT05952882
Study type
INTERVENTIONAL
Allocation
RANDOMIZED
Phase
PHASE3
Masking
NONE
Status
UNKNOWN
Enrollment
188
Start
2023-11-01
Primary completion
2025-12-31
Lead sponsor
Mỹ Đức Hospital
Conditions
Polycystic Ovary Syndrome; Obesity; Infertility, Female
Interventions
DRUG:Liraglutide + Metformin; DRUG:Metformin
Results posted
FALSE

Registered primary outcomes

  • Absolute Body Weight (BW) [12 weeks of treatment]
  • Change in Percent Body Weight [12 weeks of treatment]

Linked records (8)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.
RecordTitleYearDesignIdentifiersLink basis
R0009113The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence.
Abdalla MA, Therapeutic advances in endocrinology and metabolism
2021Nonrandomized studyPMID 33552465DOIregistry reference RESULT:33552465
R0012933Obesity, Polycystic Ovary Syndrome, and Infertility: A New Avenue for GLP-1 Receptor Agonists.
Cena H, The Journal of clinical endocrinology and metabolism
2020Narrative reviewPMID 32442310DOIregistry reference RESULT:32442310
R0012083The Discovery and Development of Liraglutide and Semaglutide.
Knudsen LB, Frontiers in endocrinology
2019Narrative reviewPMID 31031702DOIregistry reference RESULT:31031702
R0016841GLP-1 receptor agonists versus metformin in PCOS: a systematic review and meta-analysis.
Han Y, Reproductive biomedicine online
2019Systematic reviewPMID 31229399DOIregistry reference RESULT:31229399
R0021441Effect of liraglutide on ectopic fat in polycystic ovary syndrome: A randomized clinical trial.
Frøssing S, Diabetes, obesity & metabolism
2018Randomized trialPMID 28681988DOIregistry reference RESULT:28681988
R0025861Liraglutide increases IVF pregnancy rates in obese PCOS women with poor response to first-line reproductive treatments: a pilot randomized study.
Salamun V, European journal of endocrinology
2018Randomized trialPMID 29703793DOIregistry reference RESULT:29703793
R0019235Effects of liraglutide on ovarian dysfunction in polycystic ovary syndrome: a randomized clinical trial.
Nylander M, Reproductive biomedicine online
2017Randomized trialPMID 28479118DOIregistry reference RESULT:28479118
R0018103Short-term combined treatment with liraglutide and metformin leads to significant weight loss in obese women with polycystic ovary syndrome and previous poor response to metformin.
Jensterle Sever M, European journal of endocrinology
2014Randomized trialPMID 24362411DOIregistry reference RESULT:24362411