Effect of a Progressive Resistance Exercise Program on Muscle Mass and Physical Function During a Tirzepatide Induced Weight Loss in Overweight and Obese Females: a Randomised Parallel Group Study

Registration

Registration

NCT07457437

Acronym

FLEX

Study type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Status

RECRUITING

Enrollment

60

Start

2026-04-01

Primary completion

2027-12-01

Lead sponsor

University of Exeter

Conditions

Muscle Mass and Strength; Obesity & Overweight; Physical Function

Interventions

OTHER:Progressive Resistance Exercise Training Program; OTHER:Habitual physical activity guidelines

Results posted

FALSE

Individual participant data sharing

UNDECIDED

Registered primary outcomes

• Skeletal Muscle Mass [Skeletal muscle mass will be plotted over time and we will compare the pre , mid and post values (weeks 0, 10 and 20) to see if there was a change in both groups.]
• Muscle Thickness (Ultrasound) [Muscle thickness in millimetres will be plotted over time (week 0, 4, 8, 10, 12, 16, 20) and compared between the two groups. Muscle thickness will also be measure at two separate time points during a follow up study at week 40 and 72 weeks from week 0.]