LivingGLP1
Study S002015

48-week Phase II, Randomised, Double Blinded Placebo Controlled Multicentre Trial on Liraglutide's Safety, Efficacy and Action on Liver Histology and Metabolism in Overweight Patients With NASH +/- Type II Diabetes

ClinicalTrials.gov record

Registration

Registration
NCT01237119
Acronym
LEAN
Study type
INTERVENTIONAL
Allocation
RANDOMIZED
Phase
PHASE2
Masking
QUADRUPLE
Status
COMPLETED
Enrollment
52
Start
2010-08
Primary completion
2014-07
Lead sponsor
University of Birmingham
Conditions
Nonalcoholic Steatohepatitis
Interventions
DRUG:Liraglutide; OTHER:Liraglutide-placebo
Results posted
FALSE
Secondary identifiers
REGISTRY:ISRCTN85774727

Registered primary outcomes

  • Liver Histological improvement [48 weeks]

Linked records (8)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.
RecordTitleYearDesignIdentifiersLink basis
R0019138Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis.
Armstrong MJ, Journal of hepatology
2016Randomized trialPMID 26394161DOIcites ClinicalTrials.gov:NCT01237119; registry reference RESULT:26394161
R0022200Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study.
Armstrong MJ, Lancet (London, England)
2016Randomized trialPMID 26608256DOIcites ClinicalTrials.gov:NCT01237119; registry reference RESULT:26608256
R0048271OC-016 Liraglutide is effective in the histological clearance of non-alcoholic steatohepatitis in a multicentre, double-blinded, randomised, placebo-controlled phase ii trial
MJ Armstrong
2015Randomized trialDOIcites ClinicalTrials.gov:NCT01237119
R0021228Liraglutide efficacy and action in non-alcoholic steatohepatitis (LEAN): study protocol for a phase II multicentre, double-blinded, randomised, controlled trial.
Armstrong MJ, BMJ open
2013ProtocolPMID 24189085DOIcites ClinicalTrials.gov:NCT01237119; registry reference BACKGROUND:24189085
R0031504Crystal chemistry of higher tungsten oxides
, Metal Powder Report
1995Randomized trialDOIcites ClinicalTrials.gov:NCT01237119
R0031521High density processing of ferrous alloys by supersolidus liquid phase sintering
, Metal Powder Report
1995Randomized trialDOIcites ClinicalTrials.gov:NCT01237119
R0031769Correlation of particle size distribution with process parameters in gas-atomization
, Metal Powder Report
1995Randomized trialDOIcites ClinicalTrials.gov:NCT01237119
R0042154New mechanical 500 ton compacting press for production of advanced PM parts
, Metal Powder Report
1995Randomized trialDOIcites ClinicalTrials.gov:NCT01237119