Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts (CARTIZ): A Prospective Observational Multi-Institutional Registry of the VAT-Articular-Cardiac-Aging Axis in Adults Exposed to Tirzepatide in Mexico, With Quantitative Knee Cartilage T2 Mapping, Cardiac CT Epicardial Adipose Tissue Radiomic Phenotyping, HLA Stratification, Longitudinal Multi-Frequency Bioimpedance Body Composition, and a Prespecified Surgical Tissue Acquisition Subcohort

Registration

Registration

NCT07567378

Acronym

CARTIZ

Study type

OBSERVATIONAL

Status

NOT_YET_RECRUITING

Enrollment

30

Start

2026-05

Primary completion

2027-11

Lead sponsor

JULIO GRANADOS MONTIEL

Conditions

Psoriatic Arthritis; Osteoarthitis; Knee; Diabetes (DM); Type 2 Diabetes Mellitus (T2DM); Obesity (Disorder); Insulin Resistance Syndrome; Metabolic Syndrome; Heart Failure; Preserved Ejection Fraction; Coronary Artery Disease; Atrial Fibrillation (AF); Non Alcholic Fatty Liver Disease; Sarcopenia; Pericardium

Interventions

DRUG:Tirzepatide

Results posted

FALSE

Individual participant data sharing

YES

Secondary identifiers

OTHER:CARTIZ-2026-001; OTHER:64/019,134; OTHER:64/031,635; OTHER:64/039,918; OTHER:64/043,606

Registered primary outcomes

• ACR20 response rate at Week 4 in the Mechanistic Analysis Set [week 4]
• Proportion of Week-4 ACR20 response mediated by biomarker panel in the Mechanistic Analysis Set [Week 4]