Study S001988

Effect of Mazdutide on Coronary Plaque Progression in Patients With Coronary Atherosclerosis and Overweight or Obesity: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial

ClinicalTrials.gov record

Registration

Registration: NCT07657676
Study type: INTERVENTIONAL
Allocation: RANDOMIZED
Phase: PHASE4
Masking: TRIPLE
Status: RECRUITING
Enrollment: 116
Start: 2026-09-14
Primary completion: 2027-12-31
Lead sponsor: China National Center for Cardiovascular Diseases
Conditions: Obesity & Overweight; Coronary Heart Disease
Interventions: DRUG:Mazdutide; DRUG:Placebo
Results posted: FALSE
Individual participant data sharing: NO

Registered primary outcomes

Change in total non-calcified plaque volume (NCPV) by CCTA from baseline to 52 weeks [Baseline and 52 weeks]

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