LivingGLP1
Study S001921

A Phase 3, Randomized, Double-blind, Placebo-Controlled Study to Investigate the Effect of Tirzepatide on the Reduction of Morbidity and Mortality in Adults With Obesity

Registration

Registration
NCT05556512
Acronym
SURMOUNT-MMO
Study type
INTERVENTIONAL
Allocation
RANDOMIZED
Phase
PHASE3
Masking
DOUBLE
Status
ACTIVE_NOT_RECRUITING
Enrollment
15374
Start
2022-10-11
Primary completion
2027-10
Lead sponsor
Eli Lilly and Company
Conditions
Obesity; Overweight
Interventions
DRUG:Tirzepatide; DRUG:Placebo
Results posted
FALSE
Individual participant data sharing
YES
Secondary identifiers
OTHER:I8F-MC-GPIJ; OTHER:2022-501744-15-00

Registered primary outcomes

  • Time to First Occurrence of Any Component Event of Composite (All-Cause Death, Nonfatal Myocardial Infarction (MI), Nonfatal Stroke, Coronary Revascularization, or Heart Failure Events) [Up to 5 Years]

Linked records (4)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.
RecordTitleYearDesignIdentifiersLink basis
R0016508Cardioprotective effects of a 'twincretin' drug tirzepatide in heart failure following myocardial infarction.
Shang R, Cardiovascular research
2025Other trialPMID 39902650DOIcites ClinicalTrials.gov:NCT05556512
R0016928Weekly Journal Scan: long-term effects of tirzepatide for diabetes prevention in persons with obesity and prediabetes.
Pedicino D, European heart journal
2025Other trialPMID 40249363DOIcites ClinicalTrials.gov:NCT05556512
R0032683144-OR: Sustained Weight Reduction by Thresholds in Adults with Obesity and Prediabetes Treated with Tirzepatide over 176 Weeks (SURMOUNT-1)
Jamy D. Ard, Diabetes
2025Randomized trialDOIcites ClinicalTrials.gov:NCT05556512
R0020412Improvements in post-challenge lipid response following tirzepatide treatment in patients with type 2 diabetes.
Mather KJ, Diabetes, obesity & metabolism
2024Randomized trialPMID 37989596DOIcites ClinicalTrials.gov:NCT05556512