Study S001796

A Single-Arm, Open-Label, Pilot Study of Semaglutide for Non-Alcoholic Fatty Liver Disease (NAFLD), a Metabolic Syndrome With Insulin Resistance, Increased Hepatic Lipids, and Increased Cardiovascular Disease Risk (The SLIM LIVER Study)

ClinicalTrials.gov record Study Protocol (PDF)Statistical Analysis Plan (PDF)

Registration

Registration: NCT04216589
Study type: INTERVENTIONAL
Phase: PHASE2
Masking: NONE
Status: COMPLETED
Enrollment: 51
Start: 2021-02-19
Primary completion: 2023-03-16
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Conditions: HIV Infections; Non-Alcoholic Fatty Liver Disease
Interventions: DRUG:Semaglutide
Results posted: TRUE
Individual participant data sharing: YES
Secondary identifiers: REGISTRY:38453

Registered primary outcomes

Change (Absolute) in IHTG (%) [Measured at pre-entry and Week 24]

Linked records (4)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.

Record	Title	Year	Design	Identifiers	Link basis
R0006496	Pilot study of epigenetic aging and treatment response to semaglutide in the SLIM LIVER study. Corley MJ, npj aging	2026	Other trial	PMID 42014432 DOI	cites ClinicalTrials.gov:NCT04216589; registry reference DERIVED:42014432
R0015027	The Bounce-back Effect: What Happens After Cessation of Low-dose Semaglutide in People With HIV. Erlandson KM, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America	2026	Other	PMID 41299212 DOI	cites ClinicalTrials.gov:NCT04216589; registry reference DERIVED:41299212
R0003835	Epigenetic Aging and Treatment Response to Semaglutide in the SLIM LIVER Study. Corley M, Research square	2025	Other trial	PMID 41256006 DOI	cites ClinicalTrials.gov:NCT04216589; registry reference DERIVED:41256006
R0018892	Effects of Semaglutide on Muscle Structure and Function in the SLIM LIVER Study. Ditzenberger GL, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America	2025	Other trial	PMID 39046173 DOI	cites ClinicalTrials.gov:NCT04216589; registry reference DERIVED:39046173