Study S001733

The Thetis Study: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Tradipitant on Nausea and Vomiting After GLP-1R Agonist Administration in Healthy Overweight or Obese Volunteers

ClinicalTrials.gov record

Registration

Registration: NCT07446439
Study type: INTERVENTIONAL
Allocation: RANDOMIZED
Phase: PHASE3
Masking: QUADRUPLE
Status: RECRUITING
Enrollment: 280
Start: 2026-03-27
Primary completion: 2026-12-01
Lead sponsor: Vanda Pharmaceuticals
Conditions: Nausea and Vomiting; Obesity
Interventions: DRUG:Tradipitant; DRUG:Placebo
Results posted: FALSE
Individual participant data sharing: NO

Registered primary outcomes

Proportion of participants with at least 1 vomiting episode per week in the tradipitant group compared to the placebo group as measured by a daily symptom diary. [1 week]

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