LivingGLP1
Study S001698

Therapeutic Efficacy of GLP-1 on Intestinal Barrier Function in Patients With Short Bowel Syndrome and Intestinal Failure: A Preliminary Randomized Controlled Trial

ClinicalTrials.gov record

Registration

Registration
NCT07297238
Study type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
SINGLE
Status
COMPLETED
Enrollment
20
Start
2026-01-24
Primary completion
2026-05-27
Lead sponsor
Jinling Hospital, China
Conditions
Short Bowel Syndrome (SBS); Intestinal Failure
Interventions
DRUG:GLP-1 Receptor Agonists
Results posted
FALSE
Individual participant data sharing
NO

Registered primary outcomes

  • Serum Biomarkers of Intestinal Barrier Function [the initiation of enrollment and upon completion of the 28-days treatment period]

Linked records (5)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.
RecordTitleYearDesignIdentifiersLink basis
R0017155Liraglutide attenuates intestinal ischemia/reperfusion injury via NF-κB and PI3K/Akt pathways in mice.
Zou Z, Life sciences
2022PreclinicalPMID 36206837DOIregistry reference BACKGROUND:36206837
R0014618Effect of Liraglutide Treatment on Jejunostomy Output in Patients With Short Bowel Syndrome: An Open-Label Pilot Study.
Hvistendahl M, JPEN. Journal of parenteral and enteral nutrition
2018Randomized trialPMID 27875281DOIregistry reference BACKGROUND:27875281
R0012058The Glucagon-Like Peptide 1 Receptor Agonist Exenatide Inhibits Small Intestinal Motility, Flow, Transit, and Absorption of Glucose in Healthy Subjects and Patients With Type 2 Diabetes: A Randomized Controlled Trial.
Thazhath SS, Diabetes
2016Randomized trialPMID 26470783DOIregistry reference BACKGROUND:26470783
R0022016GLP-1 Induces Barrier Protective Expression in Brunner's Glands and Regulates Colonic Inflammation.
Bang-Berthelsen CH, Inflammatory bowel diseases
2016PreclinicalPMID 27542128DOIregistry reference BACKGROUND:27542128
R0027788Glucagon-like peptide-1 as a treatment for chemotherapy-induced mucositis.
Kissow H, Gut
2013PreclinicalPMID 23086829DOIregistry reference BACKGROUND:23086829