Study S001654

The Efficacy of Insulin Degludec/Liraglutide in Controlling Glycaemia in Adults With Type 2 Diabetes Inadequately Controlled on GLP-1 Receptor Agonist and OAD Therapy (DUAL™ III -GLP-1 Switch)

Name: LivingGLP1 adjudicated trial data and network meta-analysis results
Creator: Ahmad Sofi-Mahmudi
License: https://creativecommons.org/licenses/by/4.0/

Included trial: extracted data ClinicalTrials.gov record

Registration

Registration: NCT01676116
Acronym: DUAL™ III
Study type: INTERVENTIONAL
Allocation: RANDOMIZED
Phase: PHASE3
Masking: NONE
Status: COMPLETED
Enrollment: 438
Start: 2012-08-29
Primary completion: 2014-03-11
Lead sponsor: Novo Nordisk A/S
Conditions: Diabetes; Diabetes Mellitus, Type 2
Interventions: DRUG:insulin degludec/liraglutide; DRUG:liraglutide; DRUG:exenatide
Results posted: TRUE
Secondary identifiers: EUDRACT_NUMBER:2012-000209-63; OTHER:U1111-1127-1321

Registered primary outcomes

Change in Glycosylated Haemoglobin (HbA1c) From Baseline (Randomisation, Visit 2) [Week 0, week 26]

Linked records (3)

Automatic links, confirmed or rejected during screening. A record citing this registration may be a secondary analysis, a commentary or a review that mentions the trial.

Record	Title	Year	Design	Identifiers	Link basis
R0010237	Glucagon-like peptide 1 (GLP-1) receptor agonists for people with chronic kidney disease and diabetes. Natale P, The Cochrane database of systematic reviews	2025	Systematic review	PMID 39963952 DOI	cites ClinicalTrials.gov:NCT01676116; registry reference DERIVED:39963952
R0007584	EFFICACY AND SAFETY OF IDEGLIRA IN OLDER PATIENTS WITH TYPE 2 DIABETES. Lingvay I, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists	2019	Randomized trial	PMID 30383495 DOI	registry reference RESULT:30383495
R0008329	The Efficacy of IDegLira (Insulin Degludec/Liraglutide Combination) in Adults with Type 2 Diabetes Inadequately Controlled with a GLP-1 Receptor Agonist and Oral Therapy: DUAL III Randomized Clinical Trial. Linjawi S, Diabetes therapy : research, treatment and education of diabetes and related disorders	2017	Randomized trial	PMID 27943107 DOI	cites ClinicalTrials.gov:NCT01676116; registry reference RESULT:27943107